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TDMS Study 88036-03 Pathology Tables

NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99
Route: DOSED FEED                                                                                                 Time: 11:51:10

                                                      2 YEAR CHRONIC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  84-65-1

       Lock Date:  07/23/97

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1



NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 5| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 0| 1| 5| 3| 1| 3| 1| 0| 1| 4| 3| 7| 8| 3| 3| 6| 3| 4| 3| 0|             
                                           | 0| 0| 1| 2| 6| 2| 8| 2| 2| 8| 1| 3| 4| 7| 5| 5| 1| 1| 2| 0| 2| 1| 5| 2| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                            X   |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    1     1               |             
      Basophilic Focus                     | X  X  X  X  X  X  X     X  X  X        X  X        X  X  X  X  X  X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X                             X           X                              |             
      Fatty Change                         |                   2                                                      |             
      Hematopoietic Cell Proliferation     |                                     1                             1      |             
      Hepatodiaphragmatic Nodule           |    X                                                              X      |             
      Inflammation                         | 1  1  1  1        1     1     1           1           1  1  1  1  1      |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis                             |                1                                                  1      |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |    3                                                                    2|             
      Bile Duct, Hyperplasia               |                      1  1           1        3  1  1  1                 1|             
      Centrilobular, Degeneration          |                3                                                         |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                             +            |             
      Gingival, Inflammation               |                                                             3            |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  1     1  2        1     1  1     1     3  1                 1  1  1   |             
      Hyperplasia                          |                            1        1                                    |             
      Hypertrophy, Focal                   |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                           1                              |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |    4                             2                                       |             
      Inflammation                         |    4                                                                     |             
      Necrosis                             |                                                                          |             
      Ulcer                                |    3                             3           2                           |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   2      |             
      Ulcer                                |                                  1              1                        |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 5| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 0| 1| 5| 3| 1| 3| 1| 0| 1| 4| 3| 7| 8| 3| 3| 6| 3| 4| 3| 0|             
                                           | 0| 0| 1| 2| 6| 2| 8| 2| 2| 8| 1| 3| 4| 7| 5| 5| 1| 1| 2| 0| 2| 1| 5| 2| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1        1        1  1     1     1           1  1               |             
      Inflammation                         |                            1                                             |             
      Atrium, Thrombosis                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       1  1              1                       1                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       1                 1           1                 1     1     2     1|             
      Hypertrophy                          |                                                                          |             
      Mineralization                       |                                                    2                     |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1     1     1                                                   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                               2                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              4                           |             
      Cyst                                 |             1                    1              2     3                  |             
      Degeneration                         |                                                                          |             
      Pars Distalis, Hyperplasia           |       2        2     1        1  1     2     3  2     1        4  4      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1              1  1  1  1  1                    1     1         |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                         1           3     1                    1         |             
      Duct, Cyst                           | 3                                                                        |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      3        4                                2         |             
      Granulosa Cell, Hyperplasia          |          3                                                               |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  2                                       |             

                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 5| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 0| 1| 5| 3| 1| 3| 1| 0| 1| 4| 3| 7| 8| 3| 3| 6| 3| 4| 3| 0|             
                                           | 0| 0| 1| 2| 6| 2| 8| 2| 2| 8| 1| 3| 4| 7| 5| 5| 1| 1| 2| 0| 2| 1| 5| 2| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                4           2  2  2  3                 2     2     3     2|             

                                            __________________________________________________________________________|             
   Lymph Node                              |             +        +           +     +     +     +                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                      1   |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 1  2           3  2  1     1  2     2     1  1  1  2  1  1  2  1  3  2  1|             
      Infarct                              |                                  2                                       |             
      Pigmentation                         |    3  1  1        2     1  1  1           2           1  1  1  2     1  1|             
      Capsule, Fibrosis                    |                         1                       1                        |             
      Lymphoid Follicle, Atrophy           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |    3  3  3  4  4  3  4  4  3  4  4  2  4  3     3  4     4  3  3  3  4  3|             
      Artery, Inflammation                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                2              3                     |             
      Hyperplasia                          | 1                 2  1  1  2     2           1  2     3  1  2        1  2|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                         3|             
      Subcutaneous Tissue, Necrosis        |                                                                         3|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                               2                       3                  |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1        1                 1                 1        1  1  1   |             
      Pigmentation                         | 1     1  1  1  1  1  1  1  1  1  1  1  1  1           1  1  1  1  1  1  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 6| 5| 6| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 7| 0| 1| 5| 3| 1| 3| 1| 0| 1| 4| 3| 7| 8| 3| 3| 6| 3| 4| 3| 0|             
                                           | 0| 0| 1| 2| 6| 2| 8| 2| 2| 8| 1| 3| 4| 7| 5| 5| 1| 1| 2| 0| 2| 1| 5| 2| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    0 PPM                                  | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                       1                  |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                X         |             
      Inflammation                         |                                                                1         |             
      Nasolacrimal Duct, Inflammation      |    2                                                                     |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Degeneration                 |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 1  1  1     1  1  1  1  1  1  1     2     1  1        1        1     2   |             
      Infarct                              |                                                                          |             
      Inflammation                         |                            1                 1                           |             
      Nephropathy                          | 1  1  1  1        1  1  1  2  1     1     2     1  1  1  1     1  1  2  1|             
      Pigmentation                         |                      2     1  1  1  2     1     3        1     1  1     1|             
      Medulla, Mineralization              |    1        1  1     1           1  1           1  1  1           1     1|             
      Pelvis, Calculus Micro Observation   |                                                                          |             
          Only                             |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1        1  1  1     1     1                    1           1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3|            |
                                           | 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                    X     X              X                     |      6     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    1                     |      3  1.0|
      Basophilic Focus                     |       X  X     X  X  X        X  X     X  X  X  X  X  X  X  X  X  X     X|     37     |
      Clear Cell Focus                     |                                           X                              |      1     |
      Eosinophilic Focus                   |                                  X              X  X           X        X|      8     |
      Fatty Change                         |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                          2               |      3  1.3|
      Hepatodiaphragmatic Nodule           |       X                                   X              X               |      5     |
      Inflammation                         |       1  1     1  1  2           1        1  1     1  1  1  1            |     25  1.0|
      Mixed Cell Focus                     |       X                                                                 X|      3     |
      Necrosis                             | 1                                   1                                    |      4  1.0|
      Thrombosis                           |                      2                                                   |      1  2.0|
      Vacuolization Cytoplasmic            | 4                    1              2                                    |      5  2.4|
      Bile Duct, Hyperplasia               | 1     1     1        1        1           1     1                 1  1   |     17  1.1|
      Centrilobular, Degeneration          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +                                            +            |   4        |
      Fat, Necrosis                        |             3  3                                            2            |      3  2.7|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Gingival, Inflammation               |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   1     2  1  1           2     1     1  1               |     21  1.2|
      Hyperplasia                          |                                                                          |      2  1.0|
      Hypertrophy, Focal                   |                            1                                             |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                      1                                                   |      1  1.0|
      Hyperplasia                          | 2                                      2                                 |      4  2.5|
      Inflammation                         |                                                                          |      1  4.0|
      Necrosis                             | 2                                                                        |      1  2.0|
      Ulcer                                |             4           1              1                                 |      6  2.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3|            |
                                           | 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                      1                                                   |      2  1.5|
      Ulcer                                |                                                                          |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                           3                              |      1  3.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                1  1  1     2  1     1           1        1     1     1  1|     22  1.0|
      Inflammation                         |                                                                         1|      2  1.0|
      Atrium, Thrombosis                   |                         3  1                                             |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |       1                                      1                           |      6  1.0|
      Hematopoietic Cell Proliferation     |                                                          2               |      1  2.0|
      Hyperplasia                          | 1     1     1  1                          1                       1      |     13  1.1|
      Hypertrophy                          |          2           1                                         1         |      3  1.3|
      Mineralization                       |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                        3                                 |      1  3.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1     4                 2  1                                   4      |      8  1.9|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                           3                              |      1  3.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M|  42        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Cyst                                 |                   3                    1  1           1  3               |      9  1.8|
      Degeneration                         |                                                                      1   |      1  1.0|
      Pars Distalis, Hyperplasia           |    1           2  3  2     2  4  4  4     2  2        1     4        2   |     24  2.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       1  1     1  1           1           1  1  1     2  2     1     1  4|     21  1.2|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                        +                                 |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3|            |
                                           | 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                   4                                                     3|      2  3.5|
      Inflammation                         |    1                          1     1                 1        4        2|     10  1.6|
      Duct, Cyst                           |          4                 4                                   4         |      4  3.8|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             1                                4                           |      5  2.8|
      Granulosa Cell, Hyperplasia          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Vagina                                  |             +                                                            |   1        |
      Inflammation, Suppurative            |             4                                                            |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                1                 1                       1  1            |      4  1.0|
      Hyperplasia                          | 1              2     2              2  3  1  2        1     3        2   |     19  2.2|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +           +              +                                 |  10        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |       1                                      2                           |      2  1.5|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3                                                                        |      1  3.0|
      Ectasia                              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                             2            |      1  2.0|
      Fibrosis                             |             3                                                            |      1  3.0|
      Hematopoietic Cell Proliferation     | 2  1  1  1     1  1  1  1     2  1     3  1     2  2  1  1  2  2     1  1|     39  1.5|
      Infarct                              |                                                                          |      1  2.0|
      Pigmentation                         | 2     1  1     3  1  1  1  2  2  2  3  2  2     2  2  2  2     2        1|     33  1.6|
      Capsule, Fibrosis                    |                                                                          |      2  1.0|
      Lymphoid Follicle, Atrophy           |                                              3                           |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              | 4     3  4     3  4  4  4  4  4  3  4     3  3  4  3  3  3  3  3  3  3  3|     44  3.4|
      Artery, Inflammation                 |                                           4                              |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              1     3                     |      5  2.2|
      Hyperplasia                          | 3  3     1  4  1           3           2        1                 2  3   |     23  1.9|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3|            |
                                           | 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                2                                                         |      3  2.3|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             1                                                            |      1  1.0|
      Inflammation                         |                                  1                                       |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                1  1  4        1  1                 1                     |     13  1.2|
      Pigmentation                         | 1  1  1  1     1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     44  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    1                                                                    1|      3  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                  X           X        X                  |      4     |
      Inflammation                         |                      2           1           1                           |      4  1.3|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                +                    +                                    |   2        |
      Cataract                             |                2                    3                                    |      2  2.5|
      Cornea, Inflammation                 |                                     4                                    |      1  4.0|
      Retina, Degeneration                 |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                     +                                    |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        | 1     1  1     1  1  1        1  1        1  1  1  1  1  1  1  1        1|     33  1.1|
      Infarct                              |                                  2                                       |      1  2.0|
      Inflammation                         |                                  2                                       |      3  1.3|
      Nephropathy                          | 1  1  2  1     1  1  1     1  1     1     1  1  2  2  1  1  1  1     1  1|     39  1.2|
      Pigmentation                         |    1        1     1  1  1  1     1        1  1  1  1     1     1  1  3  1|     27  1.2|
      Medulla, Mineralization              | 1           1                       1        1     1                    1|     17  1.0|
      Pelvis, Calculus Micro Observation   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 6| 1| 3| 3| 6| 3| 3| 1| 0| 4| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 7| 3|            |
                                           | 6| 8| 2| 0| 5| 2| 2| 7| 5| 9| 1| 1| 6| 5| 1| 0| 1| 0| 2| 1| 1| 2| 9| 5| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Only                             |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |       1  1        1                 1                                1   |     13  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3|             
                                           | 5| 0| 1| 0| 0| 2| 1| 0| 1| 1| 0| 2| 0| 1| 2| 2| 0| 2| 1| 9| 1| 9| 2| 0| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    469 PPM                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                X         |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X     X  X        X  X                 X        X                     |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1        1        1  2                    1           1            |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |    X                             X                          X            |             
      Degeneration, Cystic                 |                                                          1               |             
      Eosinophilic Focus                   |    X  X     X     X  X  X  X  X  X  X  X        X  X     X  X        X  X|             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hepatodiaphragmatic Nodule           |                         X  X  X     X                       X            |             
      Inflammation                         |    1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  2  1  1   |             
      Mixed Cell Focus                     |    X  X  X     X     X  X  X  X  X  X        X  X     X     X     X  X   |             
      Necrosis                             | 1           1                                            1  1            |             
      Thrombosis                           |                                                          1               |             
      Vacuolization Cytoplasmic            |       1                                                                  |             
      Bile Duct, Cyst                      |                      2                                                   |             
      Bile Duct, Hyperplasia               |       1        1     1     1  1  1  1        1              1  1  1  1  1|             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Hypertrophy           |       1  1  1  1     1  1  1                    1           1     1  1  1|             

                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
      Fat, Necrosis                        |             3                                                            |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1     1        1  1  1  1     1     1        1  1  1  1  1|             
      Hyperplasia                          |                      1                                                   |             
      Hypertrophy, Focal                   |          1                                                               |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3|             
                                           | 5| 0| 1| 0| 0| 2| 1| 0| 1| 1| 0| 2| 0| 1| 2| 2| 0| 2| 1| 9| 1| 9| 2| 0| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    469 PPM                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  1  1     1  1  1  1        1           1  1        1           1|             
      Inflammation                         |    1                                      1                       1      |             
      Artery, Inflammation                 |                   2                    3                                 |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                            1                          3  1        1     1|             
      Hypertrophy                          |                         1                                                |             
      Vacuolization Cytoplasmic            |                   2                                                      |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                          1                     |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                1         |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3     3                 2                 3   |             
      Cyst                                 |                               1           1                              |             
      Pars Distalis, Hyperplasia           |    2  3                 1  3  3           1     2  4        3        3  1|             
      Pars Intermedia, Hyperplasia         |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1     1  1           1  4  1  1  1        1  1  1           1        1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                   4           3                                          |             
      Inflammation                         |    1     1  1                    1     1  1  1        1              1   |             
      Duct, Cyst                           |                                  1  4                                    |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 1                       3  2  4                                          |             
      Granulosa Cell, Hyperplasia          |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             

                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                         2                          2                     |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3|             
                                           | 5| 0| 1| 0| 0| 2| 1| 0| 1| 1| 0| 2| 0| 1| 2| 2| 0| 2| 1| 9| 1| 9| 2| 0| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    469 PPM                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |    1  1              1        2              1        1              1   |             
      Hyperplasia                          | 3  1  2        1     2  2     2        2  3     1        3  2  3  1  1  2|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                3         |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 1  2  2  2  1  1  1  1  1  1  1  1  1  1  1  1  2  1        1  1  1  1  1|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  1  2  2  2  2  2  2|             
      Pigmentation                         | 3  2  1  2  2  2  2  2  1  2  1  2  2  2  2  2  1  2  1     2  3  2  1  2|             
      Red Pulp, Depletion Cellular         |                         2                                                |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              | 2  3  4  3  3  3  3  3  3  4  3  4  3  2  2  3  3  3  3     3  4  3  4  3|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2                                   4               |             
      Hyperplasia                          |                   1                                            2         |             
      Inflammation                         |                                     3                                    |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Atrophy               |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                3         |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1  1                             1  1  1  1  1              1      |             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |                2  1                             4           1            |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                     X                                    |             
      Inflammation                         |                                     1                                    |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3|             
                                           | 5| 0| 1| 0| 0| 2| 1| 0| 1| 1| 0| 2| 0| 1| 2| 2| 0| 2| 1| 9| 1| 9| 2| 0| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    469 PPM                                | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             |                                                                          |             
      Lens, Mineralization                 |                                                                          |             
      Retina, Degeneration                 |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 1  1  3  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  2  1  1  1  2|             
      Nephropathy                          | 2  1  2  1  1  2  1  1  2  2  1  1  2  1  1  2  1  2  1  1  1  1  1  1  1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  2  1  1  1  1|             
      Medulla, Mineralization              | 1  1        1        1        1  1        1        1        1     1      |             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Hyperplasia            |                1           1              1  1              1     1      |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                       1                  |             
      Transitional Epithelium, Hyperplasia |                                     1           1  1                     |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation                         |             1                    1  1           1           1        1   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3|            |
                                           | 0| 2| 0| 6| 0| 3| 7| 1| 2| 0| 0| 1| 1| 2| 5| 2| 4| 2| 2| 2| 8| 1| 2| 0| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    469 PPM                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X                                                         |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | X                             X                                X        X|     11     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1  3                    1  1     1     1           1                 1  1|     15  1.2|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     50     |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration, Cystic                 | 1                 1                                1              1      |      5  1.0|
      Eosinophilic Focus                   |       X           X  X     X  X     X  X     X     X  X  X  X     X  X  X|     32     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |             X           X           X                       X        X   |     10     |
      Inflammation                         |    1  1  1  1  2  2  1  2  1  1  1  1  2  3  1  1  2  1  1     1  1  1  1|     46  1.2|
      Mixed Cell Focus                     | X  X  X     X                 X     X     X  X        X  X     X  X  X  X|     30     |
      Necrosis                             |                                                                          |      4  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |    1                                            1                       1|      4  1.0|
      Bile Duct, Cyst                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    1           1  1           1     1  1     1                    1     1|     22  1.0|
      Centrilobular, Degeneration          |                                           4                              |      1  4.0|
      Centrilobular, Hypertrophy           |                               1     1                 1        1  1  1   |     18  1.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                +     +                                               +   |   4        |
      Fat, Necrosis                        |                2     3                                               3   |      4  2.8|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1  1  1  1  1     1        1        1  1     1  1     1           1  1   |     27  1.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Hypertrophy, Focal                   |                         1                                                |      2  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                1                                                         |      1  1.0|
      Fibrosis                             |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 3                        |      1  3.0|
      Inflammation                         |                                                 1                        |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3|            |
                                           | 0| 2| 0| 6| 0| 3| 7| 1| 2| 0| 0| 1| 1| 2| 5| 2| 4| 2| 2| 2| 8| 1| 2| 0| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    469 PPM                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                  1                                       |      1  1.0|
      Ulcer                                |                                           1                              |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1                       1  1     1     1  1  1     1     1  1  1  1|     25  1.0|
      Inflammation                         |       1                    1  1  1                             1  1      |      9  1.0|
      Artery, Inflammation                 |                                                                          |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |             1                             2                              |      2  1.5|
      Hyperplasia                          | 1     1        1                             1        1  1  1            |     12  1.2|
      Hypertrophy                          |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                   1      |      2  1.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         1                                                |      3  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  44        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 4     3                    2                 4        3  2  2     4      |     12  2.9|
      Cyst                                 |                                        2           2     3  2           1|      7  1.7|
      Pars Distalis, Hyperplasia           | 2  4  4     1     1     2  3  2        2  1           2  4  4     4  1  4|     27  2.5|
      Pars Intermedia, Hyperplasia         |                               2                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 2  1  1     2           1  2  1  1  2  1        1     1  2  1        1  2|     29  1.3|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                                    1     4              1|      5  2.6|
      Inflammation                         |    1     1  1  1     1  1  1              1           1     1     1  1   |     21  1.0|
      Duct, Cyst                           |                                        1              2        2         |      5  2.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         2  3  3                                   2      |      8  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3|            |
                                           | 0| 2| 0| 6| 0| 3| 7| 1| 2| 0| 0| 1| 1| 2| 5| 2| 4| 2| 2| 2| 8| 1| 2| 0| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    469 PPM                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Granulosa Cell, Hyperplasia          |                                        3                                 |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                 2                        |      1  2.0|

                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                        +                                 |   1        |
      Inflammation                         |                                        3                                 |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                   4      |      1  4.0|
      Hyperplasia                          |                                     1                                    |      3  1.7|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            3  1        2     1     3              1      |     13  1.5|
      Hyperplasia                          |    1  2  3  2  2  3     2  3     1        4  3     2  1  1  2            |     31  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                    3                     |      1  3.0|
      Ectasia                              |          2                                                               |      1  2.0|
      Hyperplasia, Plasma Cell             |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    2  1  2  2  1  2  2  2  1  1  2  1  2     2  2  2  1  2  1  2  2  2  2|     46  1.4|
      Hematopoietic Cell Proliferation     | 1  2  2  2  2  2  2  2  2  2  2  1  2  2  4  1  2  2  2  2  2  2  2  2  2|     50  1.9|
      Pigmentation                         | 1  1  2     1  2     2  1  1  2  2  1        1  2  2  2  2  1  2  2  2  2|     45  1.7|
      Red Pulp, Depletion Cellular         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 4  3  3  3  4  2  4  4  4  4  3  3  4  2  3  3     3  3  3  4  4  3  3  3|     48  3.2|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     4                                    |      3  3.3|
      Hyperplasia                          |    1  2        1                    2                    1              4|      8  1.8|
      Inflammation                         |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hair Follicle, Atrophy               |                2                                                         |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        | 4                                                                        |      2  3.5|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3|            |
                                           | 0| 2| 0| 6| 0| 3| 7| 1| 2| 0| 0| 1| 1| 2| 5| 2| 4| 2| 2| 2| 8| 1| 2| 0| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    469 PPM                                | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  2                                       |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1  1     1     1                 1     1     1              1  1  1   |     18  1.0|
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     50  1.0|
      Alveolar Epithelium, Hyperplasia     |             1                                               1     2      |      7  1.7|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation                         |                            1                                             |      2  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                         +  +                                   +         |   3        |
      Cataract                             |                         2  2                                   2         |      3  2.0|
      Lens, Mineralization                 |                            2                                   1         |      2  1.5|
      Retina, Degeneration                 |                         2  2                                   2         |      3  2.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        | 1  1  2     1  3  1  1  1  1  2  1  1  1  1  1     1  2  1  1  1  1  1  1|     48  1.2|
      Nephropathy                          | 1  3  1  1  1  3  1  2  2  2  1  3  2  1     1  1  1  1  1  1  1  1  1  1|     49  1.4|
      Pigmentation                         | 2  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1|     50  1.1|
      Medulla, Mineralization              | 1  1     1     1     1     1        1  1     1  1  1  1  1     1  1      |     25  1.0|
      Pelvis, Inflammation                 |                                                                   2      |      1  2.0|
      Renal Tubule, Hyperplasia            |       1     4                 2  2           1                          1|     12  1.4|
      Renal Tubule, Hyperplasia, Oncocytic |                         1                                                |      2  1.0|
      Transitional Epithelium, Hyperplasia |    1                                                              1      |      5  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         | 1     1              1  1        1                 1     1        1  1  1|     16  1.0|
      Transitional Epithelium, Hyperplasia |                      1                                                   |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 8| 1| 2| 1| 1| 2| 1| 3| 0| 5| 1| 1| 8| 0| 1| 0| 0| 2| 2| 2| 0| 2| 2| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    938 PPM                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                          X   |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    3                     |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1  1     1     1     1  1     1  1     1  1        1  1  2        1|             
      Basophilic Focus                     | X     X     X  X  X     X  X        X     X  X  X  X  X  X  X  X  X  X   |             
      Clear Cell Focus                     |             X                                                            |             
      Degeneration, Cystic                 |                            2                                   2     1  1|             
      Eosinophilic Focus                   | X     X  X  X  X  X     X  X  X     X        X  X  X  X  X  X     X  X  X|             
      Hepatodiaphragmatic Nodule           |                                              X  X           X            |             
      Inflammation                         | 1     2  3  1  1  1  1  1  1  2  1  1     1  1  1  1  1  1  1     1  1  2|             
      Mixed Cell Focus                     | X        X  X  X                          X  X  X     X           X      |             
      Necrosis                             |                                        1              1                  |             
      Vacuolization Cytoplasmic            |                                                                1         |             
      Bile Duct, Cholangiofibrosis         |                                                       2                  |             
      Bile Duct, Hyperplasia               |       1     1           1              1     1  1              1  1  1  1|             
      Centrilobular, Degeneration          |                                  1                                       |             
      Centrilobular, Hypertrophy           | 1     1           1  1  1  1              1  1  1  1  1  1  1     1  1   |             

                                            __________________________________________________________________________|             
   Mesentery                               |             +              +           +                    +            |             
      Inflammation                         |                                                                          |             
      Fat, Necrosis                        |             3              3                                3            |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1  1        1  1              3           1  1      |             
      Pigmentation                         |       1                                                                  |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                3         |             
      Foreign Body                         |                                                                          |             
      Hyperplasia                          |                                                                3         |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                1         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                2         |             
      Erosion                              |                                  1                                       |             

                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 8| 1| 2| 1| 1| 2| 1| 3| 0| 5| 1| 1| 8| 0| 1| 0| 0| 2| 2| 2| 0| 2| 2| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    938 PPM                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                      3                                                   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1  1     1  1           1  1  1  1  1  1  1  1                    1|             
      Inflammation                         |                            1                          1                  |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       2                       1  2  2                                    |             
      Hyperplasia                          |          1     1     1                 1  1  1  1           1  1  1      |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
      Cyst                                 |       1                                                                  |             
      Pars Distalis, Hyperplasia           | 4  2  3  1                 2  1  1        2  3        1     1     1     2|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1  1  1  1        1           1     2  1  1              1        1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                   2     3     2      |             
      Inflammation                         |       1                 1                 1  1  1                        |             
      Duct, Cyst                           |          1        4                                                      |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3  1                                                               |             

                                            __________________________________________________________________________|             
   Oviduct                                 |                                        +                                 |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |          4                                                               |             
      Hyperplasia                          |                                                                          |             
      Cervix, Inflammation                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 8| 1| 2| 1| 1| 2| 1| 3| 0| 5| 1| 1| 8| 0| 1| 0| 0| 2| 2| 2| 0| 2| 2| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    938 PPM                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |       3        2  1        1        1                             1      |             
      Hyperplasia                          |    2     1                 1  2  4     2  1  1     1     2  2  1        4|             
      Infiltration Cellular, Histiocyte    |                               2                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                                 |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    3                                                                     |             
      Hyperplasia, Plasma Cell             |    4                                                                     |             
      Inflammation                         |    1                                                                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    4                     |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 1     2  2  1  2  2  2  2  1  2     2     2  1  2  2  2  2  1     2  2  2|             
      Hematopoietic Cell Proliferation     | 2  1  2  2  1  2  2  2  1  1  2  4  2     2  2  2  2  2  2  1     2  2  2|             
      Pigmentation                         | 2  3  2  2  2  1  2  2  3  2  2     1  4  1  1  2  1  2  1  1  1  2  1  1|             
      Capsule, Fibrosis                    |             1                                                            |             
      Lymphoid Follicle, Atrophy           |                                                                3         |             
      Red Pulp, Depletion Cellular         |                                                                3         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Atrophy                              | 3  4  4  4  3  4  4  3  4  3  3  4  4  4  4     3  3  3  3     4  4  4  4|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              3  2                    3   |             
      Hyperplasia                          |    3                    2        1                          3  4         |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                     1                                    |             
      Osteopetrosis                        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    2                                                                     |             
      Thrombosis                           |    1                                                                     |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                               +                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1              1  1              1  1     1                             1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 5| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|             
                                           | 0| 8| 1| 2| 1| 1| 2| 1| 3| 0| 5| 1| 1| 8| 0| 1| 0| 0| 2| 2| 2| 0| 2| 2| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    938 PPM                                | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation                         |                         2                                                |             
      Respiratory Epithelium, Inflammation |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |    +                    +                                                |             
      Cataract                             |                         3                                                |             
      Degeneration                         |    4                                                                     |             
      Inflammation                         |                         2                                                |             
      Lens, Mineralization                 |                         3                                                |             
      Retina, Degeneration                 |    3                    4                                                |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 1     1  2  2  2  1  1  1  1  1  2  2     1  2  2  1  1  1  1     1  1  1|             
      Hydronephrosis                       |                                        2                                 |             
      Infarct                              |                      1                                                   |             
      Nephropathy                          | 1     1  1  1  2  1  2  1  1  1  1  1  1  2  1  2  2  1     1  4  1  3  1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  2  1  1     1  1  1  1  1  1  1  1  1  1  1  2  2|             
      Medulla, Mineralization              | 1  1                    1  1  1  1  1  1     1  1     1        1  1      |             
      Pelvis, Inflammation                 |                      1                                                   |             
      Renal Tubule, Hyperplasia            |             1              2                    1     1        2     2   |             
      Transitional Epithelium, Hyperplasia |                      2           1                             1     1   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1           1                                               1  1|             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3|            |
                                           | 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    938 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                     2                                    |      1  2.0|
      Parasite Metazoan                    |    X                             X                                       |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    1           2                                1        2               |     18  1.2|
      Basophilic Focus                     |    X  X     X  X     X  X           X  X  X  X  X  X  X     X     X  X   |     34     |
      Clear Cell Focus                     |                               X                                          |      2     |
      Degeneration, Cystic                 |                                     1     1     1  1     1  1            |     10  1.2|
      Eosinophilic Focus                   |    X     X  X  X        X     X  X              X  X  X  X     X  X  X  X|     34     |
      Hepatodiaphragmatic Nodule           |    X           X                             X           X               |      7     |
      Inflammation                         |    1  1  1  1  2        1  2  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1|     44  1.2|
      Mixed Cell Focus                     |    X  X  X  X           X     X        X     X  X     X  X               |     20     |
      Necrosis                             |       1              1        1                                          |      5  1.0|
      Vacuolization Cytoplasmic            |                1     3                 1  1              1               |      6  1.3|
      Bile Duct, Cholangiofibrosis         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1        1        1           1     1        1  1     1  1              1|     20  1.0|
      Centrilobular, Degeneration          |                                                                          |      1  1.0|
      Centrilobular, Hypertrophy           |       1  1     2  1     1           1              1     2               |     23  1.1|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +                                +|   6        |
      Inflammation                         |                                        2                                 |      1  2.0|
      Fat, Necrosis                        |                                                                         2|      4  2.8|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1              1        2  4           1        1  3     1           2   |     16  1.6|
      Pigmentation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Foreign Body                         |                            X                                             |      1     |
      Hyperplasia                          |                            3                                             |      2  3.0|
      Inflammation                         |    1                       2                                             |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3|            |
                                           | 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    938 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1     1  1  2        1              1     1  1     1  1     1     1   |     27  1.0|
      Inflammation                         |       1                                                     1            |      4  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |             1                                   1                        |      6  1.5|
      Hyperplasia                          | 1           2           3     4  1     1              1                  |     17  1.4|
      Hypertrophy                          |          1                                                               |      1  1.0|
      Vacuolization Cytoplasmic            |                                                    1                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4           1           1              4                                 |      4  2.5|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             1                                                            |      2  2.0|
      Cyst                                 |                                                                   1  2   |      3  1.3|
      Pars Distalis, Hyperplasia           |       2  2     4              3  4                 3     4              4|     21  2.4|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1              2        1  1                 1     1        2           1|     20  1.2|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Hyperplasia                          |                               2                 2  1           1         |      8  1.9|
      Inflammation                         |    1     1                 1  1     1     1        1           1         |     13  1.0|
      Duct, Cyst                           |                                                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3|            |
                                           | 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    938 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |             1  4           3           3     4                       4  4|      9  3.0|

                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             1                                                            |      1  1.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |                1                                         3     2         |      3  2.0|
      Cervix, Inflammation                 |                            1                                             |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1        2        1                       1  2  1           1      |     13  1.4|
      Hyperplasia                          |    3        2     2  4        2  2     2  3  1  2        2  3  3  1  1   |     28  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                               1                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       2  2  2  2  1     1     2  2  2  1  1  2  1  1  2  1  1  2  1  2  2|     42  1.7|
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  1  1  2     2  1  1  2  2  2  2  2  2  2  2  2  1  1  1|     47  1.8|
      Pigmentation                         |    2  2  2  2  1  3  4  1  2  2  2  2  2  2  1  2  1  2  2  1  2  2  2  2|     48  1.8|
      Capsule, Fibrosis                    |                                                                          |      1  1.0|
      Lymphoid Follicle, Atrophy           |                            3                                             |      2  3.0|
      Red Pulp, Depletion Cellular         |                            2                                             |      2  2.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 4  2  3  3  3  3     4  4  4  4  4  4  3  3  3  4  3  2  3  3  3  2  3  4|     47  3.4|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              3                           |      4  2.8|
      Hyperplasia                          |                            3        2     1     2  2        2            |     11  2.3|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3|            |
                                           | 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    938 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Osteopetrosis                        | 2                                      3                 1               |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1        1        4  1     1           1     1  1  1     1  1        1|     19  1.2|
      Pigmentation                         |    1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     48  1.0|
      Alveolar Epithelium, Hyperplasia     |                                           1              3               |      2  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                      X                                                   |      1     |
      Inflammation                         |                                                                          |      1  2.0|
      Respiratory Epithelium, Inflammation |                      4                                                   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Degeneration                         |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  2.0|
      Lens, Mineralization                 |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        | 2  2     2  2  1  1     2  1  2  1  1  1  1  2  2  2  2  1  1  2  1  1  1|     45  1.4|
      Hydronephrosis                       |                                     2                                    |      2  2.0|
      Infarct                              |                                                                          |      1  1.0|
      Nephropathy                          | 1  1  2  1  1  1     2  2  1  1  1  1  3  1  1  1  2  1  2  1  1  1  1  1|     47  1.4|
      Pigmentation                         | 1  1  1  1  1  1     1  1  1  1  1  2  1  2  1  1  1  1  1  1  1  1  1  1|     48  1.1|
      Medulla, Mineralization              |    1  1  1  1              1  1     1           1  1  1  1  1  1  1      |     27  1.0|
      Pelvis, Inflammation                 |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                         1              1        1  2  2  2     2         |     13  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 0| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 8| 7| 3| 5| 3| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3|            |
                                           | 1| 1| 0| 1| 3| 0| 5| 0| 0| 2| 1| 1| 1| 3| 5| 2| 2| 0| 0| 1| 0| 3| 6| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    938 PPM                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Transitional Epithelium, Hyperplasia |       1     1                       1  1     1  1  1     1               |     12  1.1|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |       1                    1  1                          1               |      9  1.0|
      Transitional Epithelium, Hyperplasia |                                        2                                 |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 9| 0| 2| 2| 1| 2| 7| 2| 2| 1| 2| 1| 1| 1| 3| 0| 0| 0| 0| 4| 5| 2| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1875 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X  X     X                  |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   1      |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1                                                      |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       2                  |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1              1                          1        1           2   |             
      Basophilic Focus                     |    X  X  X  X  X     X  X  X  X  X  X        X  X     X  X  X        X  X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 | 1                                               1           1  1  1  1   |             
      Eosinophilic Focus                   | X  X  X  X  X  X  X  X     X  X     X     X  X  X     X  X           X  X|             
      Hepatodiaphragmatic Nodule           |             X                                         X                  |             
      Inflammation                         | 1  1  1  1  1  1     1     1        1  1     1  1     1  1  1        1  1|             
      Mixed Cell Focus                     |       X  X        X           X        X  X  X  X     X              X  X|             
      Necrosis                             |                      1           1                                1      |             
      Vacuolization Cytoplasmic            | 2     1                                                                  |             
      Bile Duct, Cholangiofibrosis         |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |       1  1  1     1     1        1                 1     1     1        1|             
      Centrilobular, Hypertrophy           |    1     1  1        1     1              1  1        1              2   |             
      Centrilobular, Necrosis              |                                     3                                    |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  1                 1        1     1              1  1     1  1        1|             
      Hyperplasia                          |                   1                                                      |             
      Metaplasia, Hepatocyte               |                1                                                         |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Inflammation                         |                                                                   2      |             
      Ulcer                                | 1                                1                                2      |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   2      |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 9| 0| 2| 2| 1| 2| 7| 2| 2| 1| 2| 1| 1| 1| 3| 0| 0| 0| 0| 4| 5| 2| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1875 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1  1        1     1  1        1  1  1  1        1        1  1  1|             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                     1                    1               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    1  1        1                       1     1           1  2            |             
      Hypertrophy                          |       2                    3              1                              |             
      Vacuolization Cytoplasmic            |                                                       1                  |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1              1      |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    4                 1        3                                          |             
      Pars Distalis, Hyperplasia           |    4  4     2        4     2        3     4  1     2  4  3           4  4|             
      Pars Nervosa, Hyperplasia            |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1           1                                1  3  1  3  1        1   |             
      Follicle, Cyst                       |                                     1                                    |             
      Follicular Cell, Hyperplasia         |                                                          1               |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                         3                           |             
      Inflammation                         |    1  1        1              1        1                 1           1   |             
      Duct, Cyst                           |                            3                 3              1            |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3     1           2                 3     1  4     4     4               |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                                                            |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                                                            |             
      Hyperplasia                          |       3           3              3  1     3  2  2     2           1  1  2|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                                       |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 1                                                                        |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 9| 0| 2| 2| 1| 2| 7| 2| 2| 1| 2| 1| 1| 1| 3| 0| 0| 0| 0| 4| 5| 2| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1875 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 1  2  2  2  2  2  2  2  2  2     1     2     2  2  2  2  2  2        2  2|             
      Hematopoietic Cell Proliferation     | 1  2  2  2  2  3  2  2  2  2     2  2  2     2  2  2  2  2  2     2  2  2|             
      Infarct                              |                                                                1         |             
      Pigmentation                         | 2  2  1  1  2  1  1  2  2  2  1  3  2  2     2  2  2  2  2  2     3  1  2|             
      Capsule, Fibrosis                    |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                  2                                1      |             
      Red Pulp, Depletion Cellular         |                                           2                              |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  3  4     4  4  4  4  4  3  3  4  3  4  4  3  3  3  3  3  3  3  4  3  3|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                          2                                             |             
      Hyperplasia                          |                                                 2                 2      |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 2                                                                        |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                3                                                         |             
      Osteoporosis                         |                                                                4         |             
      Maxilla, Cyst                        |                3                                                         |             
      Maxilla, Inflammation                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1        1        1        1     1     1  1  1  1              1|             
      Pigmentation                         | 1  1  1     1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia     |    3                                                              1      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cataract                             |                                        2                                 |             
      Degeneration                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 9| 0| 2| 2| 1| 2| 7| 2| 2| 1| 2| 1| 1| 1| 3| 0| 0| 0| 0| 4| 5| 2| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1875 PPM                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Degeneration                 |                                        3                                 |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 2  2  1  2  2  2  2  2     1  2        2  1  2  3  2  2  2  2        2  1|             
      Nephropathy                          | 2  1  1  1  1  1  1  2  1  2  1  1  1  2  2  2  1  1  1  1  2  1  1  2  1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Medulla, Mineralization              |          1     1              1           1  1                       1  1|             
      Renal Tubule, Hyperplasia            |          1  2                          1              2     1        1   |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
      Transitional Epithelium, Hyperplasia |                      1     3                                             |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation                         |             1  1                    1        1  1     1  1  1  1  1     1|             
      Transitional Epithelium, Hyperplasia |             3  2                                                         |             
      Transitional Epithelium, Metaplasia, |                                                                          |             
           Squamous                        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 2| 3| 1| 2| 4| 0| 1| 1| 1| 2| 0| 1| 1| 5| 1| 1| 2| 2| 0| 2| 2| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    1875 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X  X                       X                 X           X      |      8     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             1     2  1  1     1  1     1                       1  1  1   |     15  1.1|
      Basophilic Focus                     | X  X     X     X  X  X  X     X  X  X  X  X              X        X  X   |     33     |
      Clear Cell Focus                     |    X           X        X           X  X                          X      |      6     |
      Degeneration, Cystic                 |       2                                         1              1     1   |     10  1.1|
      Eosinophilic Focus                   | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X        X     X  X  X  X  X   |     39     |
      Hepatodiaphragmatic Nodule           |       X     X                          X                                X|      6     |
      Inflammation                         | 1        1  1  1  1  1  1  1  2  1  1  1  2     2  1     1  1  1  1  2  1|     38  1.1|
      Mixed Cell Focus                     | X  X                    X     X     X  X  X  X     X        X  X  X      |     23     |
      Necrosis                             |       1                 1              1                                 |      6  1.0|
      Vacuolization Cytoplasmic            |                         1           1                                    |      4  1.3|
      Bile Duct, Cholangiofibrosis         |                               2                                          |      1  2.0|
      Bile Duct, Cyst                      |                                              3                           |      1  3.0|
      Bile Duct, Hyperplasia               |       1                 1  1  1     1  1     1     1  1  1               |     20  1.0|
      Centrilobular, Hypertrophy           |          1              1  1  1        1  1  1     1     1        1      |     19  1.1|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                       +   |   3        |
      Fat, Necrosis                        |                                              3                       3   |      2  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1  1              1     1           1     1  1           1     1  1  2  1|     22  1.0|
      Hyperplasia                          |                1                                                         |      2  1.0|
      Metaplasia, Hepatocyte               |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       1                                                                  |      2  1.5|
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      3  1.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 2| 3| 1| 2| 4| 0| 1| 1| 1| 2| 0| 1| 1| 5| 1| 1| 2| 2| 0| 2| 2| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    1875 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1     1  1              1  1     1  1           1  1  1  1  1  1  1   |     28  1.0|
      Inflammation                         |                                                                      1   |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |       3                 1        1  1  1                       1     1   |      9  1.2|
      Hemorrhage                           |       3                                                                  |      1  3.0|
      Hyperplasia                          | 1        1  2     1        1        1                    4  1     1  1   |     17  1.3|
      Hypertrophy                          |                1        1  1                 1                           |      7  1.4|
      Vacuolization Cytoplasmic            |                                        2                    1        1   |      4  1.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2                                            1                     |      4  1.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |    2           2  1     3     4              1     1                     |     10  2.2|
      Pars Distalis, Hyperplasia           | 4  1     1     3  3     4     2  1                 1     4  3     1  1   |     26  2.7|
      Pars Nervosa, Hyperplasia            |                                                                   1      |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1           1  1     1  1              1           1        1     2  1|     18  1.3|
      Follicle, Cyst                       |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    1                                      2                              |      4  1.8|
      Inflammation                         |    2                 2                          1                 1      |     11  1.2|
      Duct, Cyst                           |                                                    3                     |      4  2.5|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      8  2.8|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 2| 3| 1| 2| 4| 0| 1| 1| 1| 2| 0| 1| 1| 5| 1| 1| 2| 2| 0| 2| 2| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    1875 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1                                         1            |      3  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          1  2  1  3     1     1           1     1        1     1         |     11  1.3|
      Hyperplasia                          |                      3  2                    2        1  1     2     3  2|     19  2.1|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Ectasia                              |                                                                          |      1  1.0|
      Inflammation                         |       2                                                                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 2  2     2  2  1  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2|     44  1.9|
      Hematopoietic Cell Proliferation     | 2  2  1  2  2  2  2  2  2  2  2  2  2  2  1  2  1  2  2  2  2  2  2  2  1|     47  1.9|
      Infarct                              |                                                                          |      1  1.0|
      Pigmentation                         | 2  3  4  3  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  1  2  1  2  1  3|     48  1.9|
      Capsule, Fibrosis                    |    1                                                                     |      1  1.0|
      Lymphoid Follicle, Atrophy           |       4                                                                  |      3  2.3|
      Red Pulp, Depletion Cellular         |                                              1                           |      2  1.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 3  3  4  3  3  3  3  3  4  3  4  3  4  4  4  4  3  4  3  4  3  4  4  4  3|     49  3.4|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  2.0|
      Hyperplasia                          |       3                                2                                2|      5  2.2|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      1  3.0|
      Osteoporosis                         |                                                                          |      1  4.0|
      Maxilla, Cyst                        |                                                                          |      1  3.0|
      Maxilla, Inflammation                |       4                                                                  |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 0| 3| 2| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 2| 3| 1| 2| 4| 0| 1| 1| 1| 2| 0| 1| 1| 5| 1| 1| 2| 2| 0| 2| 2| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    1875 PPM                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |       2                                                                  |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 1  1     1  1              1  1  1  1     1                    1  1      |     21  1.0|
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1|     47  1.0|
      Alveolar Epithelium, Hyperplasia     |                   1           1                          1               |      5  1.4|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |       4                                                                  |      1  4.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |       +           +                                                      |   3        |
      Cataract                             |                   2                                                      |      2  2.0|
      Degeneration                         |       4           2                                                      |      2  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        | 2  2     2  1  2  2  1  2  1  1  3  3  1  1  1  1  1  2  1  1  1  2  1  1|     44  1.7|
      Nephropathy                          | 1  2  3  1  2  1  1  1  1  2  2  1  1  1  1  2  1  2  1  1  1     1  2  1|     49  1.3|
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     50  1.0|
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1  1     1     1  1  1  1  1  1  1  1  1  1        1|     28  1.0|
      Renal Tubule, Hyperplasia            |    3     4     3  1        3  3     2                                1  2|     15  2.0|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                   2      |      1  2.0|
      Transitional Epithelium, Hyperplasia |          1                                                               |      3  1.7|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                              X                           |      1     |
      Inflammation                         |          1  1     1     1           1  1  1  1  1     2  1  1  1        1|     25  1.0|
      Transitional Epithelium, Hyperplasia |                                              4  2                        |      4  2.8|
      Transitional Epithelium, Metaplasia, |                                                                          |            |
           Squamous                        |                                              4                           |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|             
                                           | 0| 9| 1| 2| 2| 0| 0| 0| 0| 2| 2| 0| 0| 9| 1| 2| 1| 0| 0| 1| 6| 1| 0| 2| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3750 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1  1              1  1  1              1  1  1     1  1      |             
      Basophilic Focus                     |          X           X           X     X                 X               |             
      Clear Cell Focus                     |             X                                   X     X                  |             
      Degeneration, Cystic                 | 1                             1                          1     1         |             
      Eosinophilic Focus                   | X     X  X  X  X  X        X  X     X     X  X  X  X     X     X  X  X   |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Inflammation                         | 1     1  2  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1     1  1  1  2|             
      Mixed Cell Focus                     | X     X     X     X        X     X  X                    X               |             
      Necrosis                             |                               1                                1     1   |             
      Vacuolization Cytoplasmic            |                                        1        1                        |             
      Bile Duct, Cyst                      |                1                                                         |             
      Bile Duct, Hyperplasia               | 1     1  1        1                 1     1        1  1                  |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Hypertrophy           |       2  1  1  1  1     1  2  2  1        2     1  1  1  1     2        1|             

                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Fat, Necrosis                        |                                           3                              |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1  1           1                             1                     |             
      Hyperplasia                          |                                           1                              |             
      Hypertrophy, Focal                   |                                                                          |             
      Metaplasia, Hepatocyte               |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Duct, Cyst                           |                                  1                                       |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |       1                                                                  |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|             
                                           | 0| 9| 1| 2| 2| 0| 0| 0| 0| 2| 2| 0| 0| 9| 1| 2| 1| 0| 0| 1| 6| 1| 0| 2| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3750 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                           2                              |             

                                            __________________________________________________________________________|             
   Heart                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1  1  1  1  1     1  1                    1        1  1  1     1|             
      Inflammation                         |                                                                          |             
      Atrium, Thrombosis                   |                                              4                           |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                      1   |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |             2  2                                               2         |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                       1           2      |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      4                                                   |             
      Hyperplasia                          |          2        1           4                                1         |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              4        2                  |             
      Cyst                                 |                                           2                 3            |             
      Degeneration                         |                               3                                          |             
      Pars Distalis, Hyperplasia           | 1     4  1  2  3     2  1  1     3  4  3  2  2  4     4  2  4  2     1  1|             
      Pars Intermedia, Hyperplasia         |                                        1                                 |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1  1  1           1  1  1  1        2  1  1              1        1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                                          3               |             
      Inflammation                         |       1              1     2     1              1                        |             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 | 1                             3                       3                  |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
      Cervix, Hypertrophy                  |                                                                          |             
      Cervix, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|             
                                           | 0| 9| 1| 2| 2| 0| 0| 0| 0| 2| 2| 0| 0| 9| 1| 2| 1| 0| 0| 1| 6| 1| 0| 2| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3750 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst, Squamous                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2     1              1     4     1              1               |             
      Hyperplasia                          | 2  1                 1  3  2     1     2     2     2  2  2  4        3   |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                2         |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2     2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2     2  2  1  2|             
      Hematopoietic Cell Proliferation     | 2     1  2  2  2  1  2  2  2  2  2  1  1  2  2  2     1  2  3  2  2  2  2|             
      Pigmentation                         | 2     3  1  2  2  2  2  1  2  2  2  2  2  2  2  2  3  3  1     2  2  2  2|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     3  3  3  3  3  3  4  4  3  4  4     3  4  4  4  4  3  2  4  3  3  3|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                           2                 2            |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                    X                     |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                     2                                    |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                         1                                                |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                        +                                 |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation                         |       1  2           1  1     1     1        1  1     1  1  1     1     1|             
      Pigmentation                         | 1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             X                                                            |             
      Inflammation                         |             2                                                            |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|             
                                           | 0| 9| 1| 2| 2| 0| 0| 0| 0| 2| 2| 0| 0| 9| 1| 2| 1| 0| 0| 1| 6| 1| 0| 2| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    3750 PPM                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |             +           +                 +                              |             
      Cataract                             |                                           2                              |             
      Degeneration                         |             4           3                                                |             
      Hemorrhage                           |                         2                                                |             
      Retina, Degeneration                 |                                           3                              |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 1     1  2     1  1  2     1  1  1  1  1  2  1  1  1  2     2  2  3  1  2|             
      Hydronephrosis                       |                                        2                                 |             
      Nephropathy                          | 1     1  1  3  1  1  1  2  1  1  1  1  1  1  2  2  2  2  2  1  3  2  1  1|             
      Pigmentation                         | 1     2  1     1  1  1     1  2  1  1  2  1  1  1  1  1  1  1  1  1  2  1|             
      Medulla, Mineralization              | 1              1        2  1     1                    1        1     1   |             
      Renal Tubule, Hyperplasia            |       2                          1        1     1                        |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
      Transitional Epithelium, Hyperplasia |             1  1        1           1                    1     1         |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1              2        1  1  1  1     1     1            |             
      Transitional Epithelium, Hyperplasia |                               2                                      2   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 9| 4| 1| 1| 1| 0| 1| 1| 0| 0| 6| 0| 2| 8| 2| 0| 8| 1| 2| 2| 2| 0| 2| 2| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 1                 1  1           3        1  1  1  1     1  2        1   |     21  1.1|
      Basophilic Focus                     | X           X  X     X           X  X     X  X        X        X         |     15     |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration, Cystic                 | 1           1                                                            |      6  1.0|
      Eosinophilic Focus                   |       X  X     X  X  X     X        X     X  X  X  X  X  X  X  X  X     X|     34     |
      Fibrosis                             |                                                             1            |      1  1.0|
      Hepatodiaphragmatic Nodule           |             X                                X                       X  X|      5     |
      Inflammation                         | 1  1  1  1  1  2  1  1  1  1     2  2  1  2  2     2  1  1  1  1  1  2  1|     46  1.2|
      Mixed Cell Focus                     |             X     X                 X     X                          X   |     13     |
      Necrosis                             |                                                                          |      3  1.0|
      Vacuolization Cytoplasmic            |    2                                   3                                 |      4  1.8|
      Bile Duct, Cyst                      |                                  3                                       |      2  2.0|
      Bile Duct, Hyperplasia               |                         1  1        1           1                        |     12  1.0|
      Centrilobular, Degeneration          |    3                                                                     |      1  3.0|
      Centrilobular, Hypertrophy           |          2  1  1     1     2     2                          1  1  1  1   |     26  1.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   2        |
      Fat, Necrosis                        |                                              3                           |      2  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |             1                             1              1  1     1      |      9  1.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Hypertrophy, Focal                   |                      1                                                   |      1  1.0|
      Metaplasia, Hepatocyte               |                                                                1         |      1  1.0|
      Artery, Inflammation                 |                                                             3            |      1  3.0|
      Duct, Cyst                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                      1                                                   |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2                                      2                                 |      2  2.0|
      Ulcer                                |                                        1                                 |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                1                                                         |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 9| 4| 1| 1| 1| 0| 1| 1| 0| 0| 6| 0| 2| 8| 2| 0| 8| 1| 2| 2| 2| 0| 2| 2| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                    +                     |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cardiomyopathy                       |    1  1           1  1  1  1     1        1  1  1  1  1        1  1  1  1|     28  1.0|
      Inflammation                         |                                     1                    1  1            |      3  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                                                                1        1|      3  1.0|
      Hyperplasia                          |                   1     1                                         1      |      3  1.0|
      Hypertrophy                          |       1     1                                                            |      5  1.6|
      Necrosis                             |    1                                                                     |      1  1.0|
      Vacuolization Cytoplasmic            |       1                                                                  |      3  1.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  4.0|
      Hyperplasia                          |                                                    2     1               |      6  1.8|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M  M  +  M  +  +  +  +  +  +  +  M  M  +  +  +|  41        |
      Hyperplasia                          |                                        1                                 |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |    2  3                    2        2                                    |      6  2.5|
      Cyst                                 |                                                    2                     |      3  2.3|
      Degeneration                         |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |    1           2     2  2  3        3     2     2  2  1        3  2      |     32  2.3|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                      2                 1           2  1        1     2   |     18  1.2|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                     1        1                           |      3  1.7|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 9| 4| 1| 1| 1| 0| 1| 1| 0| 0| 6| 0| 2| 8| 2| 0| 8| 1| 2| 2| 2| 0| 2| 2| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |          1     1        1                          1        1  1        1|     12  1.1|
      Duct, Cyst                           |       1                                                           1     3|      3  1.7|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 3                                                                        |      1  3.0|
      Cyst                                 |                                  4     4                       3         |      6  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                            2     2                       2               |      4  1.8|
      Cervix, Hypertrophy                  |    4                                                                     |      1  4.0|
      Cervix, Inflammation                 |    4                                                                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                          +               |   1        |
      Cyst, Squamous                       |                                                          4               |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          1     1           1     3           3     1        1            |     13  1.6|
      Hyperplasia                          | 1  3  1  2        1           3     1           2     1     1            |     23  1.9|
      Inflammation                         |                                                    3                     |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |    4                                                                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           | 2     2  2  2  2  2  2  2  2     2  2     2  2  2  2  2  2  2  2  2  2  2|     45  2.0|
      Hematopoietic Cell Proliferation     | 2  3  2  2  2  1     2  2  2  3  2  2     2  2  2  2  2  2  2  2  2  2  2|     46  1.9|
      Pigmentation                         | 2  4  2  2  2  2  2  2  1  1     1  2  4  2  1  1  2  2  2  2  2  2  2  2|     47  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              | 3  4  3  3  3  3  4  3  4  3     4  3  4  4     3  3  3  4  3  3  3  4  4|     46  3.4|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                       2                  |      1  2.0|
      Hyperplasia                          |    3              4                    2                                 |      5  2.6|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 9| 4| 1| 1| 1| 0| 1| 1| 0| 0| 6| 0| 2| 8| 2| 0| 8| 1| 2| 2| 2| 0| 2| 2| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Gliosis                              |                                                                          |      1  2.0|
      Inflammation                         |                                                                         1|      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                                    X                     |      1     |
      Inflammation                         | 1  1  1        1  1        1              1  1  1  1                 1   |     24  1.0|
      Pigmentation                         | 1  1  2  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1|     48  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |          +           +                                                   |   5        |
      Cataract                             |          2           2                                                   |      3  2.0|
      Degeneration                         |                                                                          |      2  3.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Retina, Degeneration                 |          2           2                                                   |      3  2.3|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accumulation, Hyaline Droplet        | 1     3  2  1  2  3  2  1  3     2  1  1  1  2  1  2  2  3  2  2  1  3  2|     44  1.7|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          | 2  2  2  2  2  1  2  1  1  2  1  1  1  1  1  2  1  1  2  1  2  2  2  2  1|     49  1.5|
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1|     47  1.1|
      Medulla, Mineralization              |    1  1  1     1  1     1        1  1              1  1        1        1|     20  1.1|
      Renal Tubule, Hyperplasia            | 3     1     1        2     1                 2                       1   |     11  1.5|
      Renal Tubule, Hyperplasia, Oncocytic |                                              1                           |      1  1.0|
      Transitional Epithelium, Hyperplasia |       1     1           1                    1                           |     10  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         | 1     1  1                       1  1                 1     1     1     1|     17  1.1|
      Transitional Epithelium, Hyperplasia |                                                 1                       1|      4  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|             
                                           | 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                       X                             X|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             4                                                            |             
      Inflammation                         |       1     1                                                            |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                             1            |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                         1                     |             
      Basophilic Focus                     |          X  X  X     X  X     X     X  X     X  X  X     X     X  X      |             
      Clear Cell Focus                     |          X                                      X  X           X  X      |             
      Congestion                           |                                                                2         |             
      Degeneration, Cystic                 |             1                 1           1  1  1                        |             
      Eosinophilic Focus                   |             X                             X                    X  X      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X                             X  X        X                     |             
      Inflammation                         | 1  1     1     1  1                    1           1     1              1|             
      Mixed Cell Focus                     |                                                    X           X  X      |             
      Necrosis                             | 1                    3                                1                  |             
      Pigmentation                         |                                                                         1|             
      Thrombosis                           |                                                       1                  |             
      Vacuolization Cytoplasmic            | 1  3              2                                         4     2      |             
      Bile Duct, Cyst                      |                                                    1                     |             
      Bile Duct, Hyperplasia               | 1  1  1  1  1  1     1  1  1  2  1  1  1  2  1  1  1  2  1     1  1  1  1|             
      Centrilobular, Degeneration          |       3                                               3                  |             

                                            __________________________________________________________________________|             
   Mesentery                               |             +        +     +     +           +        +                  |             
      Inflammation                         |                                                       2                  |             
      Fat, Necrosis                        |             3        3     3     3                    3                  |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +                                                                     |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  1     2     1              1     2  2     2  1  2        2     1   |             
      Hyperplasia                          |                                  1                             4         |             
      Hypertrophy, Focal                   |                                                                   1      |             
      Artery, Inflammation                 |                3                                                         |             
      Duct, Hyperplasia                    | 1                                                                        |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                           |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             3            |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|             
                                           | 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                                     X                                    |             
      Hyperplasia                          |    1        2                                               4            |             
      Inflammation                         |    2                                2                       3            |             
      Ulcer                                |    2                                                        4            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |             2        1                                                   |             
      Ulcer                                |       1                                                     1            |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2        2                                                   |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  1  1  2  1  1  2  1        2  1  1  2  1  2  1  2  1     2  1  2   |             
      Mineralization                       |             3                                                            |             
      Atrium, Thrombosis                   |       2           1           1                       2                  |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             3                          1     1                 1  1      |             
      Hyperplasia                          |          1              1           1           1           1            |             
      Hypertrophy                          |                                                          1               |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                            3                          1                  |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1        3     1     1        3     1                    2  2      |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   1                                                      |             
      Hyperplasia                          |             2                                               1            |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                 3                        |             
      Pars Distalis, Hyperplasia           |          1     1           4                 2  2              3         |             
      Pars Nervosa, Hyperplasia            |                                                                1  1      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1  1  1  1        1        1        1  3                 1      |             
      Follicle, Cyst                       |                                              2                           |             
      Follicular Cell, Hyperplasia         |                                  1           1                           |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             


                                                             Page  45                                                               
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|             
                                           | 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
      Inflammation                         | 2  1  1  2  2  2  1  1  2     3  2  2  1  1  1  2  2  1  1  1     1     2|             
      Duct, Ectasia                        |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 2  2  1  1  2     2     1  2  1  3     3  1     3     1  2  1  1  2  2  1|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |             2                                                            |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      4     4                             4              4|             
      Artery, Inflammation                 |                   2                                                      |             
      Interstitial Cell, Hyperplasia       | 1  1     1        1  1     1  1  1  1  1  1        1     1  1            |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
      Hyperplasia                          |       3  3  3  2     1  3        3        4  3  1              1  2     2|             
      Myelofibrosis                        |                                                       2                  |             
      Necrosis                             |                                                       2                  |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                            +  +                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        1                       2     1   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                       4                  |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Ectasia                              |    2                                                                     |             
      Hemorrhage                           | 4                                                        2               |             
      Necrosis                             |                                                       4                  |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Congestion                           |          2  2  2                                                         |             
      Fibrosis                             |             1                             3                              |             
      Hematopoietic Cell Proliferation     | 1  1     1  1  2  1  1  1  1  1  2     1     1  1  1        2  1     2   |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                          |             
      Necrosis                             |                                                       3                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|             
                                           | 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |             1     1                    2                 1  2           2|             
      Capsule, Fibrosis                    |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                                   2      |             
      Red Pulp, Depletion Cellular         |                                                                   2      |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  4  4  3  4  3  4  4  4        3  4  3  4  3  4  4     4  3  3  3  4  3|             
      Necrosis                             |                                                       4                  |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                            1                    3           2  2         |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                   X      |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             2              1                                             |             
      Necrosis                             |                                                       2                  |             
      Osteopetrosis                        |                                                       3                  |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            1                                             |             
      Cerebrum, Degeneration               |                            2                                             |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +                                                                        |             

                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1                    1           1     1           1     1|             
      Mineralization                       |             1                                                            |             
      Pigmentation                         |                                                 1                        |             
      Thrombosis                           |                                                                         1|             
      Alveolar Epithelium, Hyperplasia     |                                                    1     1               |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       X                       X           X           X                  |             
      Inflammation                         |       2                       2           1           2                  |             
      Respiratory Epithelium, Inflammation |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +                                +                                       |             
      Cataract                             | 2                                2                                       |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 8| 9| 7| 3| 8| 2| 2| 8| 3| 2| 2| 6| 2| 4| 7| 3| 3| 3| 4| 3| 0| 2| 3| 6| 3|             
                                           | 5| 3| 4| 0| 1| 9| 0| 8| 0| 4| 9| 5| 9| 0| 7| 0| 0| 0| 5| 0| 8| 9| 0| 9| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Degeneration                 | 3                                3                                       |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                            1                                      1      |             
      Cyst                                 |          1                                                               |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation                         |             1                                      1  3           1      |             
      Mineralization, Diffuse              |             1        1                                                   |             
      Nephropathy                          | 1  3  1  3  4  3  3  3  3  1  2  2  3  2  2  2  3  2  1  3  4  3  3  1  2|             
      Pigmentation                         |       2                 1  1  1     1  1     1     1           1  1     1|             
      Medulla, Mineralization              |    1  1     1     1  1  1     1  1  1     1  1  1  1        1     1     1|             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |    1     2  1  1  1  1  1        1  1        1  1     1  1  1  1  1     1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                       1                                      1  1      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3|            |
                                           | 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                      X   |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                        X                                X|      5     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      2  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                1                                                         |      2  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   1  1           1                    1                  |      6  1.0|
      Basophilic Focus                     |                   X  X     X  X  X     X     X  X  X     X        X      |     25     |
      Clear Cell Focus                     |                   X  X           X                 X                     |      9     |
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                   1           1           1                       1      |      9  1.0|
      Eosinophilic Focus                   |                   X                    X           X              X     X|      9     |
      Hematopoietic Cell Proliferation     |                            1                    1                        |      2  1.0|
      Hepatodiaphragmatic Nodule           |                                  X                                       |      5     |
      Inflammation                         |          1              1        1                 1                     |     13  1.0|
      Mixed Cell Focus                     |                                                    X                     |      4     |
      Necrosis                             |                                                    1     1               |      5  1.4|
      Pigmentation                         |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      5  2.4|
      Bile Duct, Cyst                      |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 2  1  3  1  2  3  2  1  1  1  2  1  2  2  2  3  1  1  1  2  2  1  1  3  2|     48  1.4|
      Centrilobular, Degeneration          |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                 +                             +  +            |  10        |
      Inflammation                         |          1                                                               |      2  1.5|
      Fat, Necrosis                        |                                                             3            |      6  3.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1  1     1              1  4  1     2  1  1  1     1  2        2     1   |     26  1.5|
      Hyperplasia                          |                                                                          |      2  2.5|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3|            |
                                           | 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Duct, Hyperplasia                    |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |             4                                                            |      2  3.5|
      Foreign Body                         |                                                                          |      1     |
      Hyperplasia                          |             1                                                            |      4  2.0|
      Inflammation                         |             3                                                            |      4  2.5|
      Ulcer                                |             3                                                            |      3  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |             1  1                                                         |      2  1.0|
      Fibrosis                             |    2                                                                     |      1  2.0|
      Inflammation                         |                                                          1               |      1  1.0|
      Mineralization                       |                                                                          |      2  1.5|
      Ulcer                                |                                              1                           |      3  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |    2                                                                     |      3  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2  2     2  1  2  2  1  1     1     1  1  1     1  1  1  1  2  2|     42  1.5|
      Mineralization                       |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                               4                       2                  |      6  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                      1           1                                       |      7  1.3|
      Hyperplasia                          |                               1                             1        1   |      8  1.0|
      Hypertrophy                          |                         1  1        3                                    |      4  1.5|
      Pigmentation                         | 3                                                                        |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                3         |      3  2.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2     2  1  1        1     4        1        4     1            |     17  1.8|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Hyperplasia                          |    2                 1                                               1   |      5  1.4|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                1         |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3|            |
                                           | 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                            1  1                                          |      2  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |       1              1     1  1        3                             2  2|     13  1.8|
      Pars Nervosa, Hyperplasia            |                                  1           1                       1   |      5  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                4              1     1              1              1      |     14  1.4|
      Follicle, Cyst                       |                            1  1                                          |      3  1.3|
      Follicular Cell, Hyperplasia         |       1                                                                  |      3  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       4                                2                                 |      3  2.7|
      Inflammation                         | 2           2  1  2  2     1  1  1  2  2  1     4  2  1  2  1  1  2  2  2|     42  1.6|
      Duct, Ectasia                        |                                                                   4      |      1  4.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            1                                             |      1  1.0|
      Inflammation                         | 2  3  2        2  1  3  3              2                    2  1  3  1  2|     33  1.8|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    2                                                                     |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                         4                                   1            |      6  3.5|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       | 1  1  1  1  1  1              1        1  1  1              1  1  1      |     27  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                 2                        |      2  2.5|
      Hyperplasia                          | 2  2        2     1  3     3     2                 2  3  4  2           3|     25  2.4|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +  +                    +     +                    +         |   8        |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |             1                                                            |      1  1.0|
      Mediastinal, Pigmentation            | 2                                                                        |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3|            |
                                           | 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |             1     1           1                                   2  2   |      8  1.4|
      Hyperplasia, Plasma Cell             |                                  2                                3     4|      3  3.0|
      Inflammation                         |       1                                                                  |      1  1.0|
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          3                                                               |      2  3.0|
      Ectasia                              | 2                                                           2            |      3  2.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                X                                                         |      1     |
      Congestion                           |                      2           2                 2                     |      6  2.0|
      Fibrosis                             | 3                                                  2                    2|      5  2.2|
      Hematopoietic Cell Proliferation     | 1  1     1     1  1  2  1  2     1     1  1  1  1  1  1  2  1  1  1      |     37  1.2|
      Hemorrhage                           |             2                                                  1         |      2  1.5|
      Infarct                              |             2                                                            |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |    1     1        1  1  1        1                                       |     12  1.3|
      Capsule, Fibrosis                    |                                                                   2      |      1  2.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
      Red Pulp, Depletion Cellular         |                                                       1              2   |      3  1.7|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Atrophy                              | 3  4  3  3  3     3     3  4  4        3     4  3  3  3     4     3  3  3|     40  3.4|
      Necrosis                             |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +|  45        |
      Hyperplasia                          |                      2  1              2                          2  1  2|     10  1.8|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      2  1.5|
      Necrosis                             |                                                                          |      1  2.0|
      Osteopetrosis                        |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 5| 4| 7| 7| 7| 5| 6| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 5| 3| 6| 9| 2| 2| 3| 3| 4| 0| 3| 9| 2| 8| 3| 4| 3| 2| 1| 4| 6| 3| 3| 3|            |
                                           | 5| 5| 0| 2| 9| 9| 9| 0| 7| 8| 5| 0| 0| 9| 7| 0| 8| 0| 4| 7| 2| 5| 0| 0| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 9| 0| 2| 4| 5| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             2                                                            |      2  1.5|
      Cerebrum, Degeneration               |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      1  1  1                    1     1                  |     11  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Pigmentation                         |                            1        1                                    |      3  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |          2                                                               |      3  1.3|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      4     |
      Inflammation                         |                                                                          |      4  1.8|
      Respiratory Epithelium, Inflammation |                                                                1         |      1  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  2.0|
      Retina, Degeneration                 |                                                                          |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                         1|      3  1.0|
      Cyst                                 | 2                                                                 1      |      3  1.3|
      Hydronephrosis                       |    3                                                     2               |      2  2.5|
      Infarct                              |                               1                                          |      1  1.0|
      Inflammation                         |                   1  1                             1                     |      7  1.3|
      Mineralization, Diffuse              |    1                                                                     |      3  1.0|
      Nephropathy                          | 1  2  2  1  1  2  2  3  2  2  2  2  2  2  1  2  2  2  2  2  2  1  3  3  2|     50  2.2|
      Pigmentation                         | 4           3  2           3  1  1  1  3     1     1     2     1  1  1   |     25  1.5|
      Medulla, Mineralization              | 1     1        1  1     1  1  1     1           1  1  1  1     1  1      |     30  1.0|
      Renal Tubule, Hyperplasia            |                      1              1  1                                 |      3  1.0|
      Transitional Epithelium, Hyperplasia |       1        1  1  1     1  1     1        1        2           1  2   |     28  1.1|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    4     1                 1     1                                       |      8  1.4|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        


                                                             Page  53                                                               
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|             
                                           | 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    469 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                             X                  |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                    1                     |             
      Ulcer                                |                                                                      2   |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                2                                                         |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                2                                                         |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     1                 1  1        1  1     1        1        2  1      |             
      Basophilic Focus                     |    X  X     X  X     X  X  X        X  X     X     X  X  X  X     X      |             
      Clear Cell Focus                     |             X           X                                                |             
      Degeneration, Cystic                 | 1  2     1  1  1     1     2     1     1  2        1  1  1        1  1  1|             
      Eosinophilic Focus                   |       X     X  X     X  X  X        X        X     X  X                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X                             X              X                 X         |             
      Inflammation                         |       1     1  1     1  1  1  1  1  1  1        1     1           1      |             
      Mixed Cell Focus                     |       X                    X        X                                    |             
      Necrosis                             |    1                                               2                     |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |                         1           2     2           1     2            |             
      Bile Duct, Hyperplasia               | 1  2  2  1  1  2  1  2  1  2  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1|             
      Centrilobular, Degeneration          |                                                          2               |             
      Centrilobular, Hypertrophy           |                            1                                             |             
      Centrilobular, Necrosis              |                                           3                              |             

                                            __________________________________________________________________________|             
   Mesentery                               |                      +              +        +                           |             
      Fat, Necrosis                        |                      3              3                                    |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1     1     1     2  1  1     1        1     1     1  4  1  2   |             
      Hyperplasia                          |                                                    2  4                  |             
      Hypertrophy, Focal                   |             1                                         1                  |             
      Inflammation                         |                                     1                                    |             
      Artery, Inflammation                 |                                                                   3      |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                          4            |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|             
                                           | 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    469 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                               3  2                          3            |             
      Hyperplasia                          | 3                             2  3                 2        2        2  3|             
      Perforation                          |                                                                          |             
      Ulcer                                | 4                                2                 4        4        3  1|             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 1                                                           1            |             
      Fibrosis                             |                                                                          |             
      Mineralization                       |    3                             3        1                              |             
      Ulcer                                |                                                    1                 1   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    4                                                                     |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  3  2  1  1  1  1  1  1  1  1  2  2     1  2  1     2  2  1     2  1   |             
      Inflammation                         |                1                                                         |             
      Mineralization                       |    1                                                                     |             
      Artery, Inflammation                 |                                  2                                       |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                       1  1               |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Hyperplasia                          | 2  1                       1                                      1      |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                  2                                   4   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        1  1     2  1  3     1        3  1     1     4  1  1     2   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          | 2  2                 1        2  3                 2  2     1        3  1|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    3                     |             
      Cyst                                 |                   1                                                      |             
      Pars Distalis, Hyperplasia           | 1     4     1        4     4  1           3  1  3  4     1     2     2   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                       1                  |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     2        1                 1  3  1              2        1     4   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                               2                                         2|             
      Follicular Cell, Hypertrophy         |                                                                         1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             

                                                             Page  55                                                               
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|             
                                           | 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    469 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |             1                                                            |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1           2                                    |             
      Inflammation                         | 1  2  2     2  2        1  2     1     1  2     1              2     2  1|             
      Duct, Ectasia                        |          1                          4                                    |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation                         | 1  3  3  1     1  1  4     3        2  3        3  3     1  3     2  4  3|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4                                   4                                3  4|             
      Interstitial Cell, Hyperplasia       | 1     1  1  1  1     1     1        1  1  1     1  1     1        1  1  1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 1  1        1  1        2     2     1     3  3        2  3     3        3|             

                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                                     +         |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |    2                                                                     |             
      Hyperplasia, Plasma Cell             |                            3                                   3         |             
      Inflammation                         |    1                                                                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                4                                                        2|             
      Hemorrhage                           | 2                                                                        |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       2     2  2     2  2  2  2  1  3  2     2  2     2     1     2     2|             
      Hematopoietic Cell Proliferation     |    2  1     1  1     1  1  1  2  2  1     3  2  1  2  1  1     1  1  1  1|             
      Infiltration Cellular                |                                                                          |             
      Pigmentation                         | 3  1  1           3  2  1     1  2     2  1     2  2        3     2  3  3|             
      Red Pulp, Depletion Cellular         |                      2                                                   |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +|             
      Atrophy                              | 4  4  3  4  3  4  3  4        4  4  4  3  4  3  4     4     4        4  4|             
      Epithelial Cell, Hyperplasia         |                                                                4         |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|             
                                           | 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    469 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 2  3  1              2              2  3           2  2     2  2  2  4   |             
      Mineralization                       |    2                                                                     |             
      Duct, Hyperplasia                    |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Atrophy               |                                                                         2|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2                             2                                       |             
      Osteomalacia                         | 2  2                 2        2  2                          2           1|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                      X   |             
      Inflammation                         |                   2                    1     2        1  1           1  1|             
      Mineralization                       |    3                                                                     |             
      Pigmentation                         |                               1     1              1                 1   |             
      Alveolar Epithelium, Hyperplasia     | 1     2                    1                             1           2   |             
      Mediastinum, Inflammation            |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    X              X                                                      |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |    2              4                                                      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |       1                    1           1     2  1        1        1      |             
      Cyst                                 |                                  1                       1               |             
      Inflammation                         |                                     1                    1               |             
      Mineralization, Diffuse              |    2                                                                     |             
      Nephropathy                          | 4  4  3  2  2  2  1  4  3  2  4  4  4  3  3  3  2  4  4  3  4  3  2  4  4|             
      Pigmentation                         | 1  1  1     1  1     1  1           1  1  1  1     1        1  1  1  1   |             
      Medulla, Mineralization              |    1  1  1  1  1     1        1  1  1  1  1  1  1  1  1  1  1  1  1      |             
      Renal Tubule, Hyperplasia            | 2                                                                        |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 6| 0| 2| 6| 3| 2| 7| 2| 3| 2| 3| 1| 2| 8| 2| 6| 9| 2| 3| 7| 6| 0| 7| 1| 4|             
                                           | 9| 8| 9| 8| 0| 9| 7| 9| 0| 9| 0| 0| 9| 2| 4| 3| 7| 9| 0| 6| 3| 5| 6| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    469 PPM                                | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Hyperplasia | 1  1  2     1  1     2  2     1  1  2  1  1     1  1  1  1  2  1  1  1  2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1              1     1  1                       1                    1   |             
      Transitional Epithelium, Hyperplasia |                                                                      2   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3|            |
                                           | 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    469 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |       4                                                                  |      1  4.0|
      Ulcer                                |       4                                                                  |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                       X                  |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             X  X        X                 X           X                  |      7     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1           1        2  1     1        1  1  1  1                    1  1|     21  1.1|
      Basophilic Focus                     | X  X     X  X  X     X  X  X  X  X  X  X  X     X  X  X        X  X  X  X|     35     |
      Clear Cell Focus                     |          X                          X                             X      |      5     |
      Degeneration, Cystic                 | 1     1     1  1  1  2  2     2           2  2  1  1  1        1        1|     31  1.3|
      Eosinophilic Focus                   | X           X        X  X     X     X  X  X  X     X  X           X      |     22     |
      Hematopoietic Cell Proliferation     |                            1                                             |      1  1.0|
      Hepatodiaphragmatic Nodule           |                   X                       X           X  X              X|      9     |
      Inflammation                         | 1           1     1  1  1        2  1     1  1     1  1  1  1  1  1  1  1|     30  1.0|
      Mixed Cell Focus                     |          X  X  X        X     X     X        X     X  X                  |     12     |
      Necrosis                             |                         1  1           1                                 |      5  1.2|
      Thrombosis                           |                                                                1         |      1  1.0|
      Vacuolization Cytoplasmic            |       4  1  1        1  1     1                    1  1     2  1  1  2  1|     18  1.4|
      Bile Duct, Hyperplasia               | 2  1  1  1  1  1  1  2  1  1  1  1  2  1  1  2  1  1  1  1  1  1  1  1  2|     50  1.2|
      Centrilobular, Degeneration          |                   1                                                      |      2  1.5|
      Centrilobular, Hypertrophy           |             1  1                             1                           |      4  1.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   4        |
      Fat, Necrosis                        | 3                                                                        |      3  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1     1     1  2  1     2  2           3  1  2  1  1  2  1  1  1  3      |     30  1.5|
      Hyperplasia                          |          1                                                     2         |      4  2.3|
      Hypertrophy, Focal                   |          1                    1              1        1                  |      6  1.0|
      Inflammation                         | 1                                                                        |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3|            |
                                           | 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    469 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       2                                                                  |      3  2.7|
      Inflammation                         |                1                                                         |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                 3                        |      4  2.8|
      Hyperplasia                          | 3     3           1                             3                        |     11  2.5|
      Perforation                          |       X                                                                  |      1     |
      Ulcer                                | 4                                               2                        |      8  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |       1     2                                                            |      4  1.3|
      Fibrosis                             |                            1                                             |      1  1.0|
      Mineralization                       |                      3                                                   |      4  2.5|
      Ulcer                                |                                                                          |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             1        4                                                   |      3  3.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  2  1  1  1  1  3  1  1  1  2  1  1  1  2     2  2  2  1  1  1  1   |     44  1.4|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |                      1                                                   |      2  1.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                     1                          2         |      4  1.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |       1        1  1        1           1                             1   |     10  1.1|
      Hypertrophy                          |                                     1                                    |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             2     1  2     1  1  1  2     2        1                    1|     24  1.6|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                         2                                                |      1  2.0|
      Hyperplasia                          |                      3                                         2        2|     13  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3|            |
                                           | 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    469 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                   1                                   1                  |      3  1.0|
      Pars Distalis, Hyperplasia           |                      2  1  4  3     2  2  2  1     1           4  4  4  2|     26  2.4|
      Pars Intermedia, Hyperplasia         |                      2                                                   |      1  2.0|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |          1  1  1              1     1  1  1     1  1  1  1        1  1   |     22  1.4|
      Follicle, Cyst                       |                                                    1                    2|      2  1.5|
      Follicular Cell, Hyperplasia         |          1                                                               |      3  1.7|
      Follicular Cell, Hypertrophy         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       | +                                                                        |   1        |
      Inflammation                         | 4                                                                        |      1  4.0|

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  1.0|
      Mineralization                       |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                1                                                     2   |      4  1.5|
      Inflammation                         | 1     1  2  2  2  1     1  1  1  2  2  2  2  3  1     1        2  1  2  2|     34  1.6|
      Duct, Ectasia                        |          2                       2                                       |      4  2.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            2                                             |      1  2.0|
      Inflammation                         | 4  3  2  4     3  1     3  1  1  3        1  2  3  2  2  3  2     3  3  4|     37  2.5|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                          1               |      1  1.0|
      Inflammation                         | 2                                                                        |      1  2.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            4     4                       1     4     4  4|     10  3.6|
      Interstitial Cell, Hyperplasia       | 1  1  1           1        1        1              1  1     1  1     1   |     27  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |          2     2                                                         |      2  2.0|
      Hyperplasia                          | 2  4        2  2     2     3  2     3  2  2  2        1        2  2     3|     28  2.1|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   3        |
      Renal, Hyperplasia, Plasma Cell      | 3                                                                        |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3|            |
                                           | 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    469 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                         1                                                |      2  1.5|
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.0|
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                   2     1                       1                        |      5  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 2  1     2  2           2     2  1  2  2  2  1     2  2  2  1  2  1  2  2|     35  1.8|
      Hematopoietic Cell Proliferation     | 2  2  1  1  1  1  1  1  1  4  1  1  2  2  1  1  3  1  1  1  1  2  1  2  2|     45  1.4|
      Infiltration Cellular                |                4                             2                           |      2  3.0|
      Pigmentation                         | 1  1  4  2  1        2  1  1     2     1  1  1  1  1     2  2  1  1  1  1|     36  1.7|
      Red Pulp, Depletion Cellular         |                                              3                       2   |      3  2.3|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  44        |
      Atrophy                              | 3  3  4  4  4  4  3  3  3  4  3  4  3  3  4  3     3  4  2  4  4  3  4  4|     43  3.6|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                           4                              |      1  4.0|
      Hyperplasia                          | 3     2  1           3  1                       1           3        3  2|     21  2.2|
      Mineralization                       |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |                                           3                              |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hair Follicle, Atrophy               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                4         |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                      2                                         1         |      4  1.8|
      Osteomalacia                         |       2     1  1     2                          1              2         |     13  1.7|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 1| 3| 2| 2| 9| 7| 2| 4| 3| 6| 2| 2| 2| 3| 0| 3| 3| 8| 7| 2| 3| 2| 3|            |
                                           | 0| 1| 5| 0| 9| 9| 7| 6| 9| 5| 0| 3| 9| 4| 4| 0| 5| 0| 0| 1| 4| 4| 0| 9| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    469 PPM                                | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |             1        2  1        1  1                          1         |     13  1.2|
      Mineralization                       |                      2                                                   |      2  2.5|
      Pigmentation                         | 1                                                                       1|      6  1.0|
      Alveolar Epithelium, Hyperplasia     |                                           3     1     1           4      |      9  1.8|
      Mediastinum, Inflammation            |       3                                                                  |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |       X                                                                  |      3     |
      Hemorrhage                           |                                        3                                 |      1  3.0|
      Inflammation                         |       1                                                                  |      3  2.3|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |    1                          1     1                 1  2  1     2      |     14  1.2|
      Cyst                                 |                                                                2        1|      4  1.3|
      Inflammation                         | 1           1                                      1                     |      5  1.0|
      Mineralization, Diffuse              |                      2                                                   |      2  2.0|
      Nephropathy                          | 4  2  4  3  4  4  1  4  3  2  2  3  2  4  3  3  4  3  3  2  3  4  2  4  4|     50  3.1|
      Pigmentation                         | 1     2  1        1     1  2  1  1  1  1  1  1  1  1                 1   |     31  1.1|
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1     1  1  1  1  1|     42  1.0|
      Renal Tubule, Hyperplasia            |                      2  1                       1              1  2  1   |      7  1.4|
      Transitional Epithelium, Hyperplasia | 1  1  1  1  2  1     2  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1|     45  1.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |             1     1                                                      |      8  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|             
                                           | 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    938 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                          X                 X         |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   1      |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2              1  1                    1  1     1           1|             
      Basophilic Focus                     |       X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X         |             
      Clear Cell Focus                     |                                  X     X              X  X               |             
      Degeneration, Cystic                 |       1  1     1     1  1     2     1  1  2  1     1  1  2  1  2  1  1   |             
      Eosinophilic Focus                   |          X     X  X  X  X  X  X  X  X  X  X        X     X     X        X|             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Hepatodiaphragmatic Nodule           |                                     X                                    |             
      Inflammation                         | 1        1     1  1  1  1     1  1     1  1           1        1  1     1|             
      Mixed Cell Focus                     |          X              X                 X           X  X              X|             
      Necrosis                             |             1                       1        3  3                        |             
      Vacuolization Cytoplasmic            |       1           1  3     1  1  1           1        1  1              1|             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |    1  2  1  1  2  1     1  1  1  1  1  2  2  1  1  1  1  2  1  2  1     1|             
      Centrilobular, Degeneration          |    2                                                                     |             
      Centrilobular, Hypertrophy           |          1        1     1     1  1     1  2        1  1     1  1        1|             

                                            __________________________________________________________________________|             
   Mesentery                               |                                              +  +        +               |             
      Fat, Necrosis                        |                                                          3               |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                          +               |             
      Pharyngeal, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1        1     2  2  2  1     2  1  2     1     1  1        1|             
      Hyperplasia                          |                                                                         1|             
      Hypertrophy, Focal                   |                1     1                                                   |             
      Inflammation                         |                                                                          |             
      Artery, Inflammation                 |                2                       3                                 |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                   4      |             
      Hyperplasia                          |    2        2                       1                             3      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|             
                                           | 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    938 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Perforation                          |                                                                          |             
      Ulcer                                |       2     1                                                            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |    2        2        2                                      1            |             
      Ulcer                                |       1     1                                                            |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    4                 4                                                   |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Cardiomyopathy                       |       2  1     1  1  1  1  2  1  1     1  1  1     1  1  1  2  1  1  1  1|             
      Inflammation                         |                                     2                                    |             
      Mineralization                       |             1                                                            |             
      Atrium, Thrombosis                   |    4                                                                     |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Cystic                 |                                     1              1                     |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia                          |                                                    1     1               |             
      Hypertrophy                          |                                                                          |             
      Thrombosis                           |             1                                                            |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2           1        1                    2     2     1  1      |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |    3        1        3        2                    2              1  1   |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    1        2            |             
      Hemorrhage                           |                                        3                                 |             
      Pars Distalis, Hyperplasia           |    1     2  1           1  1  2  1     4  1        2  1  2              2|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1  4           1     1                       1  1     1         |             
      Follicle, Cyst                       |                                                    2                     |             
      Follicular Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|             
                                           | 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    938 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1                                       |             
      Infiltration Cellular                |                                                                          |             
      Inflammation                         | 1  1  1  2  1  1  1  1  1  1     1  1     2     1  1  2  2     1  2     1|             
      Duct, Ectasia                        |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  2  3     3  3  4  4  1        1  2  2        1  2  2  3  3  3  1  1|             
      Metaplasia, Squamous                 |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            3                                             |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     4                                4   |             
      Interstitial Cell, Hyperplasia       | 1  1  1  1     1  1  2  1                                      1  1     1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3  2  2  2     2     3  3  3  4  2  3  3  3  2     2  3  3        2|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +                        |             
      Mediastinal, Ectasia                 |                                                 1                        |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Ectasia                              |                1                                                         |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           3                              |             
      Ectasia                              |          3                             2                                 |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                   X                                                      |             
      Angiectasis                          |                                     1                                    |             
      Congestion                           |          3     2  2  1  1     1  2  1  2  2        2  2  2  1  2  1     1|             
      Fibrosis                             |    3                          1     2                                    |             
      Hematopoietic Cell Proliferation     |    2  4  1  3  1  1  3  2  2  1  2  3  1  2  3  3  1  1  2     1        1|             
      Pigmentation                         | 1  1  1  1  2  1  1  1  2  2     1  3  1           1  1  1  2     2  1  1|             
      Lymphoid Follicle, Atrophy           |                                                             4            |             
      Red Pulp, Depletion Cellular         |                                                                         2|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4  4     4  4  4  4     4  3  4  2  4  4     2  3  3  4  3  4  4  4|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                   1        3        3                             1      |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|             
                                           | 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    938 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Dermis, Fibrosis                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    2        1        2                                                   |             
      Osteomalacia                         |    2  1     2                                                     2  2   |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     3                                    |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |    2                                                                     |             
      Inflammation                         |                      2        1  1  4                                    |             
      Mineralization                       |    1                                                                     |             
      Pigmentation                         |                   1                       1                              |             
      Alveolar Epithelium, Hyperplasia     |                               3           4     2                 1      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               X     X                       X            |             
      Inflammation                         |                               2     3                                    |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                                                                        |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                         +                                      +         |             
      Cataract                             |                                                                2         |             
      Inflammation                         |                                                                          |             
      Cornea, Inflammation                 |                         4                                                |             
      Retina, Degeneration                 |                         3                                      3         |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 1        1        1     2                       2              1         |             
      Cyst                                 |                                        1     1        4              1   |             
      Hydronephrosis                       |                            2                                             |             
      Inflammation                         |                                                    1                     |             
      Mineralization, Diffuse              |    2  2              1     1        1                                    |             
      Nephropathy                          | 1  4  4  2  4  2  2  4  2  3  4  3  4  2  3  4  2  4  2  3  3  2  4  4  3|             
      Pigmentation                         |    1  2  1  1     1  1        1  1  1  1  1  1  1     1  1        1     1|             
      Medulla, Mineralization              | 1  1  1  1     1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1|             
      Renal Tubule, Hyperplasia            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7|             
                             DAY ON TEST   | 1| 9| 6| 3| 0| 2| 2| 2| 2| 4| 3| 3| 3| 2| 2| 0| 0| 2| 3| 2| 6| 2| 8| 9| 2|             
                                           | 2| 9| 1| 0| 4| 0| 9| 4| 9| 3| 0| 0| 8| 9| 9| 5| 3| 9| 0| 9| 6| 4| 2| 6| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    938 PPM                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |    2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  2     2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            4                                             |             
      Inflammation                         |                      1     3     1     1              1                  |             
      Serosa, Inflammation                 |                                                 4                        |             
      Transitional Epithelium, Hyperplasia |                                                 1                        |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0|            |
                                           | 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    938 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                            3                                             |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                   X      |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                    X     X           X                        |      7     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  1.0|
      Ulcer                                |    1                                                                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2  1                                      1        2        1        2|     13  1.3|
      Basophilic Focus                     |    X     X           X  X  X  X  X  X        X  X  X  X  X     X  X     X|     35     |
      Clear Cell Focus                     |                         X                                         X      |      6     |
      Degeneration, Cystic                 | 2  1     1  1  1     1  1  1  1  1  1           2  1  2  1  1  1     1  1|     36  1.2|
      Eosinophilic Focus                   | X  X  X  X           X  X        X     X     X     X  X  X     X  X     X|     30     |
      Hematopoietic Cell Proliferation     |          1                                                  1            |      3  1.0|
      Hepatodiaphragmatic Nodule           |                                                                   X      |      2     |
      Inflammation                         |       1           2  1  1     1  1  1     1  1        1     1  1  1     1|     28  1.0|
      Mixed Cell Focus                     |             X        X  X     X  X           X  X              X  X      |     15     |
      Necrosis                             | 1                                                                        |      5  1.8|
      Vacuolization Cytoplasmic            |       1     2        1        1  1  1        1  1  2  1  2     1  1      |     23  1.2|
      Bile Duct, Cyst                      |                                                                         2|      1  2.0|
      Bile Duct, Hyperplasia               | 1  1  1  2  1  2  1  1  2  1  1  1  1  1  1  2  1  1  1  1  1  2  1  1  2|     47  1.3|
      Centrilobular, Degeneration          |             2                                                            |      2  2.0|
      Centrilobular, Hypertrophy           |    1     1           1        1        1  1  1  1                 1      |     21  1.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +                                         +            |   6        |
      Fat, Necrosis                        |                2                                                         |      2  2.5|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                             +            |   2        |
      Pharyngeal, Hyperplasia              |                                                             2            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    1     1  1     1     1     1     1           1     1  1     2        1|     25  1.2|
      Hyperplasia                          |                                                                      2   |      2  1.5|
      Hypertrophy, Focal                   |                                  1                                       |      3  1.0|
      Inflammation                         |                         1                    1                           |      2  1.0|
      Artery, Inflammation                 |                                                                   1      |      3  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0|            |
                                           | 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    938 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                               1                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |    2                                                                     |      2  3.0|
      Hyperplasia                          | 3  3                       3                                             |      7  2.4|
      Inflammation                         |                                                          4           1   |      2  2.5|
      Perforation                          |                                                          X               |      1     |
      Ulcer                                |    4                                                                 1   |      4  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                          3               |      1  3.0|
      Inflammation                         |                                                                      1   |      1  1.0|
      Mineralization                       | 2           3                                      3                     |      7  2.1|
      Ulcer                                |                            1                                             |      3  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             4                                      4                     |      4  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cardiomyopathy                       | 2  1  1  1  2  2  1  1  1  1  1  1  1  1  1  1  2  3  1  1     2  1  1  1|     44  1.2|
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |             2                                      2        1            |      4  1.5|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                   X      |      1     |
      Degeneration, Cystic                 |          1                                                               |      3  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |          1  1                          1     1                    1     2|      8  1.1|
      Hypertrophy                          |                1                             1                           |      2  1.0|
      Thrombosis                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1  4  1     2  3  1              1  2        1     1     2     1  1     3|     22  1.6|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 2  2     4  4  1           2     3              1  3           2     3  2|     19  2.2|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |             4                                                            |      3  2.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0|            |
                                           | 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    938 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                3  1  4  2  2  3  4              2     3        1        4|     24  2.1|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |                                  1  1        1  1     1     3     1      |     14  1.4|
      Follicle, Cyst                       |                                                             2     3      |      3  2.3|
      Follicular Cell, Hyperplasia         |                         1                                                |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       2        2         |      3  1.7|
      Infiltration Cellular                |                                  3                                       |      1  3.0|
      Inflammation                         | 1  1  1  2  2  1  2  1  1  2  4     2  2     2  1  1  2  1  2  2  2  2  3|     43  1.5|
      Duct, Ectasia                        |    4              1           4                       4                  |      4  3.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1     1     3  2     1  1  3  2  3        2  3  1     2     3     2  3|     36  2.2|
      Metaplasia, Squamous                 |                                                                3         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                4                                                         |      2  3.5|
      Mineralization                       |             3                                                            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            4  1        4  4              4               |      7  3.6|
      Interstitial Cell, Hyperplasia       | 1     1  1        1     1  1  1     1  1  1     1     1           1  1  1|     26  1.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3     2     2  3  3  1  2     1  1     2  3  2     2  2     3  2  2     3|     37  2.4|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Mediastinal, Ectasia                 |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectasia                              | 2                                                                        |      2  1.5|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |          3        2                 3        2                 2         |      7  2.4|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0|            |
                                           | 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    938 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                                                                          |      1  1.0|
      Congestion                           |    2  2  1  1  1  2  2  2     1  1  2     1  2        2  1  2  2  2  1  2|     37  1.6|
      Fibrosis                             |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     | 3  1  1  1  1     1  1  1  1  1  1  2     1  1  1  3  1  2  3  2  2  2  1|     44  1.7|
      Pigmentation                         | 1  2  1     3  3     1  1  2  1  1  1  2  1        1  1  2        1  1   |     38  1.4|
      Lymphoid Follicle, Atrophy           |                            2                                             |      2  3.0|
      Red Pulp, Depletion Cellular         |                               2                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Atrophy                              |    4  4  4  4     3  4  4  4  4  3  4  4  2  2  4  4  3  4  2  2  3  4  3|     44  3.5|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |    1        3  3              2     1              1     2        1      |     12  1.8|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                     X                                    |      1     |
      Dermis, Fibrosis                     |                         4                                                |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 2        2  2                                      3                 1   |      8  1.9|
      Osteomalacia                         | 2  2     3     1           3                             1           3   |     12  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                            X           X                                 |      2     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         |             1  1     1     4           3           2  1        2  1      |     13  1.8|
      Mineralization                       |             2                                      1                     |      3  1.3|
      Pigmentation                         |       1                                               1                  |      4  1.0|
      Alveolar Epithelium, Hyperplasia     |                   1  1           2                          1  3         |      9  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    X                                                        X  X     X   |      7     |
      Inflammation                         | 2  2                       1                                2  1     2   |      8  1.9|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 1| 3| 0| 2| 8| 6| 2| 2| 8| 3| 3| 3| 0| 7| 2| 3| 2| 2| 4| 1| 3| 2| 6| 0|            |
                                           | 8| 9| 0| 5| 3| 7| 3| 9| 9| 0| 0| 0| 0| 3| 7| 9| 0| 3| 9| 8| 9| 0| 9| 5| 5|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    938 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                            +         |   4        |
      Cataract                             |                   4                                                      |      2  3.0|
      Inflammation                         |                                                                4         |      1  4.0|
      Cornea, Inflammation                 |                                                                          |      1  4.0|
      Retina, Degeneration                 |                   4                                                      |      3  3.3|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   2        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |       1        1        1                 1                              |     10  1.2|
      Cyst                                 | 2  2        2                                   2              4         |      9  2.1|
      Hydronephrosis                       |                2                                                         |      2  2.0|
      Inflammation                         |                                                       1                  |      2  1.0|
      Mineralization, Diffuse              | 1           3  1                                   3                     |      9  1.7|
      Nephropathy                          | 4  4  2  4  4  4  3  2  2  4  2  3  3  2  2  3  4  4  2  4  2  4  3  4  3|     50  3.1|
      Pigmentation                         | 1  1  1  1     1  3  1  1     1  1  1        1  1     1  1  3     1  1  1|     36  1.1|
      Medulla, Mineralization              | 2  1  1  1  1     1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1     1|     46  1.0|
      Renal Tubule, Hyperplasia            |    2        1                                                     1      |      3  1.3|
      Transitional Epithelium, Hyperplasia | 2  2  2  1  1     1  2  2  1  2  2  2        2  2  2  1  1  1  2  1  1  2|     44  1.4|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                4                                                         |      2  4.0|
      Inflammation                         |          1     2  1                                      1        1     1|     11  1.3|
      Serosa, Inflammation                 |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|             
                                           | 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1875 PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation                         |       2                                                                  |             
      Mineralization                       |                   1                                                      |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   1                                                      |             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation                 | 3                                                                        |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                1        1           1     1  2                    1      |             
      Basophilic Focus                     | X        X     X  X  X  X     X     X     X  X  X  X  X     X     X  X   |             
      Clear Cell Focus                     |                                     X                             X      |             
      Degeneration, Cystic                 |          1     1  1  1     1  1        1  2  1  1  1     2  1  1     3   |             
      Eosinophilic Focus                   |                X        X  X        X     X     X  X     X  X     X  X  X|             
      Hematopoietic Cell Proliferation     |                1                                         1     1         |             
      Hemorrhage                           |                                                                      2   |             
      Hepatodiaphragmatic Nodule           |    X                                      X                          X   |             
      Inflammation                         | 1  1              1  1  1  1  1     1  1     1  1  1  1     1     1     1|             
      Mineralization                       |          2                                                               |             
      Mixed Cell Focus                     |                                     X     X        X        X     X  X   |             
      Necrosis                             |          3                                1              1               |             
      Vacuolization Cytoplasmic            | 1                    2     1        1     1     1  1              1      |             
      Bile Duct, Hyperplasia               | 1  1     2  2  1  1  1  2  2  2  1  2  1  1  1  1  1  1  1  1  1  1  1  2|             
      Centrilobular, Degeneration          |                                                                3         |             
      Centrilobular, Hypertrophy           |                                     1           1           2     1      |             
      Centrilobular, Necrosis              |    2                                                                     |             

                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                +  +         |             
      Artery, Inflammation                 |                                                             3            |             
      Fat, Inflammation                    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  2        1  1     2  1        1        1  1  1  2     1  1  1     1|             
      Hyperplasia                          |                   3                          2                           |             
      Hypertrophy, Focal                   |                                                                   1      |             
      Inflammation                         |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Artery, Mineralization               |          4                                                               |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|             
                                           | 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1875 PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                1                                                         |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       3                  |             
      Hyperplasia                          |                               2                       3                  |             
      Mineralization                       |                   1                                                      |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       2           1                                                      |             
      Inflammation                         |                                                                          |             
      Mineralization                       | 2        3        3           2        2                                 |             
      Ulcer                                |                                                       1                  |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 4                 4           2                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  2  1  2     1  1  1     1  1  1     1  1  2  1  1     1     1|             
      Inflammation                         |                            1                                         1   |             
      Mineralization                       |                   1           3                                          |             
      Atrium, Thrombosis                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2              1                       1                 1           2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    1        1  1     1                 1  1                 1           1|             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |    2                                                                     |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     1           4     4  1  1        1  1  2           2  3        2   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                      2                                                   |             
      Hyperplasia                          | 3        3        3     3     1        3              2  2        1      |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Cyst                                 |                                                 2     1                  |             
      Thrombosis                           |    2                                                                     |             
      Pars Distalis, Hyperplasia           | 1           1  4     2  2  1  1     1     4  2        2     4  1  1     4|             
      Pars Intermedia, Hyperplasia         |                                              1                           |             
      Pars Nervosa, Hyperplasia            | 1                                                                        |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1  1                                            4        2   |             
      Follicle, Cyst                       |                                           1  1           2               |             
      Follicular Cell, Hyperplasia         |                                                          4               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|             
                                           | 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1875 PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                         2                       1                        |             
      Inflammation                         |                               1                                          |             
      Mineralization                       |                   2                                                      |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  2  2  1  2     1  2  2  1  1  1  2  1  1  1     2  1  1  2     2   |             
      Duct, Ectasia                        |                                           1              2               |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Hyperplasia                          |             1                                                            |             
      Inflammation                         |    2  2  3  1  1     3  4     2     4  3           3        2     1     3|             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                   4                                                      |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4                                                  4        4   |             
      Thrombosis                           |    2                                                                     |             
      Artery, Inflammation                 |                                                                          |             
      Interstitial Cell, Hyperplasia       |    1                       1  1  1  1                       1  1     1  1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 2     3  2  3  3  3  2  2  1     3     1  2  1     2     4  2  3  1  1  2|             
      Myelofibrosis                        |    3                                                                     |             

                                            __________________________________________________________________________|             
   Lymph Node                              |       +                                                                  |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1                                                      |             
      Atrophy                              |                                                                          |             
      Ectasia                              | 1                                                  3        4        4   |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2  2  1  3  2  1        2     2  2  2  1  2     2     2  3  2|             
      Fibrosis                             |                                        4                                 |             
      Hematopoietic Cell Proliferation     | 1     2     1  2  1  1  1  1     2  1     2  2  1  1  1  3  1  3  2  2  1|             
      Infiltration Cellular                |                                                 4                        |             
      Pigmentation                         | 3        1  1     1  1  1  1  2     1     1  1  2     1           1     1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|             
                                           | 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1875 PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Depletion Cellular         |                                                                   1      |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4     3  3  3  4     3  4  2  3  4  3  4  3  4  4  3  4  4  3  3  3|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2  2           1  3           1        1            |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hemorrhage                           |          3                                                               |             
      Hyperplasia                          |                                                    2                     |             
      Dermis, Fibrosis                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2        1        2                    1                                 |             
      Osteomalacia                         | 2        3        2                    2              2                  |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                            X                                             |             
      Hemorrhage                           |                   1                                                      |             
      Inflammation                         | 1        1           1                             1                     |             
      Mineralization                       | 1        3        2           1                                          |             
      Necrosis                             |    3                                                                     |             
      Pigmentation                         |                1                    1  1                       1         |             
      Thrombosis                           |    2                                                                     |             
      Alveolar Epithelium, Hyperplasia     |             1                 4                                   4      |             
      Mediastinum, Thrombosis              |       4                                                                  |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   X        X                                             |             
      Inflammation                         |                   3        2           3                                 |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |          +              +                                         +  +   |             
      Cataract                             |          3              2                                         2  2   |             
      Degeneration                         |                                                                          |             
      Hemorrhage                           |                         2                                            3   |             
      Mineralization                       |          2              2                                         1  1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2| 7| 6| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 6|             
                             DAY ON TEST   | 1| 8| 0| 2| 2| 1| 2| 2| 3| 2| 3| 4| 3| 9| 3| 2| 2| 3| 5| 9| 2| 9| 2| 2| 0|             
                                           | 7| 3| 5| 7| 9| 9| 8| 9| 0| 8| 7| 9| 0| 0| 0| 9| 9| 0| 3| 0| 9| 3| 9| 9| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1875 PPM                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Inflammation                 |                                                                      2   |             
      Retina, Degeneration                 |          4              3                                         3  3   |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |       1     1  2                 1  1     1        1     1     1         |             
      Cyst                                 |                1                             2                           |             
      Inflammation                         |                         1                 1  1                       1   |             
      Mineralization, Diffuse              | 1        3        2           3        1                                 |             
      Nephropathy                          | 4  2  2  4  2  2  4  3  4  3  4  1  3  4  3  4  4  3  4  2  2  1  3  3  2|             
      Pigmentation                         |       1     1  1     1  1           1  1  1  1  1  1  1  1  1  3  1  1   |             
      Thrombosis                           |    1                                                                     |             
      Medulla, Mineralization              | 1  1  1  1  1  1  1  1  3  1  1  1  1  1  1  1  1  1     1     3  1  1  1|             
      Renal Tubule, Hyperplasia            |       4              1                          1                 1  1   |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
      Transitional Epithelium, Hyperplasia | 1  1  1  2  1  1  1  1  2  1  1     2  2  2  1  2  1  1  2  2  1  2  1  1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1        1                                      1  1  1  1|             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2|            |
                                           | 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1875 PPM                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                | 3                                                                        |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                              X  X        X  X     X      |      5     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1              1                          1                              |      9  1.1|
      Basophilic Focus                     |       X        X  X  X  X     X     X  X  X  X  X        X     X  X  X  X|     32     |
      Clear Cell Focus                     |                      X     X  X           X     X                 X      |      8     |
      Degeneration, Cystic                 | 3  1  1  1        2  1  1  1           1           1  1              2  1|     28  1.3|
      Eosinophilic Focus                   |          X  X  X  X  X     X  X        X  X     X     X  X  X  X  X  X  X|     29     |
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                     X                 X                  |      5     |
      Inflammation                         |    1  1  1     1     1        1     1     1  1  1     1     1  1        1|     30  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Mixed Cell Focus                     |          X     X     X        X                 X        X              X|     13     |
      Necrosis                             | 1                                                  3  1              2   |      7  1.7|
      Vacuolization Cytoplasmic            |          1     1     1           2  1     1              1  1        2   |     17  1.2|
      Bile Duct, Hyperplasia               | 2  1  1  1  2  1  2  1  1  1  1  1  2  2  1  1  1  2  1  1  1  1  2  2  1|     49  1.3|
      Centrilobular, Degeneration          |                                                                          |      1  3.0|
      Centrilobular, Hypertrophy           |    1     1     1     1        1           1     2           1     1      |     13  1.2|
      Centrilobular, Necrosis              |                                  3                                       |      2  2.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                       +              +        +      |   7        |
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Fat, Inflammation                    |                                                                   2      |      1  2.0|
      Fat, Necrosis                        |                                           3              3               |      2  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1              1     1  2  1  1     1  3        1              2  2  1   |     28  1.4|
      Hyperplasia                          |                                                                          |      2  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2|            |
                                           | 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1875 PPM                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy, Focal                   |                               1                                          |      2  1.0|
      Inflammation                         |                                                             1            |      1  1.0|
      Artery, Inflammation                 |          2                                                               |      1  2.0|
      Artery, Mineralization               |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                         2|      2  2.5|
      Hyperplasia                          |                                  3                                      2|      4  2.5|
      Mineralization                       | 3                                                                        |      2  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      2  1.5|
      Inflammation                         |       1                                                                  |      1  1.0|
      Mineralization                       | 3                                1                 3  3              3   |     10  2.5|
      Ulcer                                |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       | 4                                                  2  3              3   |      7  3.1|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3  1  1  2  1  1  1  1  2  1  1  1  1  1  1  1     2  2  2  1  1  2  2  2|     43  1.3|
      Inflammation                         |                                                                          |      2  1.0|
      Mineralization                       | 3                                   1              3                     |      5  2.2|
      Atrium, Thrombosis                   |                                                                      2   |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 | 3                 1                                                      |      7  1.6|
      Hemorrhage                           | 2                                                                    3   |      2  2.5|
      Hyperplasia                          |             1              1           1                    1     1      |     13  1.0|
      Hypertrophy                          |                      1     2              1                       1      |      4  1.3|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                 1              1  1        2        1              2  1|     20  1.7|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          | 4              1  2     1        2                    3  4  1  1  2  3   |     20  2.3|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2|            |
                                           | 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1875 PPM                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                      4   |      3  2.3|
      Thrombosis                           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |       1     1     3  4     1  1                 3  1  1  1     2  1  4   |     28  2.0|
      Pars Intermedia, Hyperplasia         |                                                                      4   |      2  2.5|
      Pars Nervosa, Hyperplasia            |          1              1     1                                          |      4  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1     2              1                 1     4              1  1  1  1|     13  1.6|
      Follicle, Cyst                       |                2                       1                                 |      5  1.4|
      Follicular Cell, Hyperplasia         |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                               1                                          |      3  1.3|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Inflammation                         |    1  2  1  2  2  2     1  2  2  1  2        2  1        1  2  2         |     37  1.6|
      Duct, Ectasia                        | 3                                3                                       |      4  2.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation                         |    3  3  2  2  3     2     1  1  3  3     2  4  1     3     2  1     2   |     31  2.3|
      Mineralization                       | 2                                                                        |      1  2.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Inflammation                         |                               1                                          |      1  1.0|
      Mineralization                       | 2                                                                        |      2  3.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 4              4                                      4                  |      6  4.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Artery, Inflammation                 |                                              2                           |      1  2.0|
      Interstitial Cell, Hyperplasia       | 1  1  1  1           1  1     2  1        1        2  1     1     1  1  1|     24  1.1|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                2         |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2|            |
                                           | 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1875 PPM                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          | 3     2  1  3  2        2        2  3  4        1  2  3  2     1  2  2   |     36  2.2|
      Myelofibrosis                        |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                      2   |      1  2.0|
      Ectasia                              |                               2                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                         3                                                |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Atrophy                              |                                                                      3   |      1  3.0|
      Ectasia                              |          1           2                                         2         |      7  2.4|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 1  1  2  2           2        1     2  1  2  2  1        2  2  2         |     30  1.8|
      Fibrosis                             |                            1                                             |      2  2.5|
      Hematopoietic Cell Proliferation     | 1  1  2  2  1     2  2  2     1  3  1  1  1  2  1  2  3  1  1  2  1  1   |     43  1.5|
      Infiltration Cellular                |                                                                          |      1  4.0|
      Pigmentation                         | 1  2  1  1  1  1              1  2  1  1  1  2  1  2  1     1  1        1|     33  1.2|
      Lymphoid Follicle, Atrophy           |                                                                      3  3|      2  3.0|
      Red Pulp, Depletion Cellular         |                1                                                     2  2|      4  1.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              | 4  4  3  3  3  4  3  3  3  3  3  4     3  4     3  4  4  4  4  3  3  4  4|     46  3.5|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4  1  3        1                 1           1                           |     12  1.8|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                  X                                       |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Dermis, Fibrosis                     |                                                                      4   |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 2                 1                                2  2     1        2  2|     11  1.6|
      Osteomalacia                         |                                                    2     2  2            |      8  2.1|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2|            |
                                           | 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1875 PPM                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           |                                                                      3   |      2  2.0|
      Inflammation                         |                                     1           1                 1  2   |      8  1.1|
      Mineralization                       | 3                                                  1  1                  |      7  1.7|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                         1|      5  1.0|
      Thrombosis                           |                                                                      3   |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                               2                             1     4  3   |      7  2.7|
      Mediastinum, Thrombosis              |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                      X                                         X        X|      5     |
      Inflammation                         |                      2                                         1        2|      6  2.2|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   5        |
      Cataract                             |                                                                          |      4  2.3|
      Degeneration                         |                         3                                                |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      4  1.5|
      Cornea, Inflammation                 |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      4  3.3|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |    2  1        1     1        1        1  1                              |     16  1.1|
      Cyst                                 | 1                 2                             1        3              3|      7  1.9|
      Inflammation                         |                                                                1         |      5  1.0|
      Mineralization, Diffuse              | 3                                                  1  2                  |      8  2.0|
      Nephropathy                          | 4  2  2  2  3  4  4  3  3  3  2  4  2  2  3  4  2  4  4  4  4  3  3  4  4|     50  3.0|
      Pigmentation                         |    1  1  1  1  1  1  1  2  1  1  2  2  1     1  1  1     1  1  1  1     1|     38  1.1|
      Thrombosis                           |                                                                          |      1  1.0|
      Medulla, Mineralization              | 1  1  1  1     1  1  1  1  3  1  2  1  1  2  1  1  1  1  1  1  1  1  1  1|     47  1.2|
      Renal Tubule, Hyperplasia            |                                                       1     2        1  2|      9  1.6|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                      2   |      1  2.0|
      Transitional Epithelium, Hyperplasia | 2  1  1  1  1  1  1     1  2  2  2  1  1  2  1  2  1  1  1  1  2  2  2  1|     48  1.4|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 1| 2| 2| 2| 1| 3| 7| 2| 3| 9| 0| 6| 3| 2| 3| 9| 2| 2| 3| 3| 2| 3| 2|            |
                                           | 1| 7| 9| 9| 9| 9| 9| 0| 4| 9| 0| 0| 5| 3| 0| 9| 0| 0| 0| 9| 0| 0| 9| 0| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    1875 PPM                               | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                         1                                   1            |      8  1.0|
      Transitional Epithelium, Hyperplasia |             1                                                            |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|             
                                           | 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     1                                    |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                      1        1                 1      |             
      Basophilic Focus                     | X  X                 X        X     X     X     X           X        X  X|             
      Clear Cell Focus                     | X                                                                        |             
      Degeneration, Cystic                 | 1        1  1        2  1           1  1  1  1  2  1        1     1     1|             
      Eosinophilic Focus                   | X                    X  X     X        X                             X   |             
      Hepatodiaphragmatic Nodule           |             X  X           X                                             |             
      Inflammation                         | 1  1     1        2  1  1              1              1     1     1  1  1|             
      Mixed Cell Focus                     |    X                    X                                   X        X   |             
      Necrosis                             |                   2                                                      |             
      Thrombosis                           |                                  1                                       |             
      Vacuolization Cytoplasmic            | 1                    2  1     1        1  2  2        1     1        1  1|             
      Bile Duct, Hyperplasia               | 1  1     1  3  2  1  1  1  1  1  1  1  2  2  1  1  2  1  1  1     1  2  1|             
      Centrilobular, Degeneration          |                2                                                         |             
      Centrilobular, Hypertrophy           | 1  1                    1  1  1  1  1        1        1     1  1  1  2  2|             
      Centrilobular, Necrosis              |       3                                                                  |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +                                         +                 +      |             
      Artery, Mineralization               |                                                 3                        |             
      Fat, Necrosis                        |       3                                                           3      |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1     2  1     2     1           2  1  1        1  1           1  1|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy, Focal                   |                                                                      1   |             
      Artery, Hypertrophy                  |                   4                                                      |             
      Artery, Inflammation                 |                            2                          2                  |             
      Artery, Mineralization               |                      2        2              2                           |             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +|             
      Atrophy                              |       1                                                                  |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|             
                                           | 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                     2                                    |             
      Hyperplasia                          |                                     2              2                     |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                               1              2  2                        |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                            1                                             |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                1                                                         |             
      Mineralization                       |       1              2        4     2  2  2  4  3                        |             
      Ulcer                                |                      1                                                   |             

                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
      Inflammation                         |                   4                                                      |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      3        3           1  4  4                        |             
      Aorta, Aneurysm                      |                                              3                           |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1     1  2  1  1  3  1     1  1  3  3  2  1  1  1     2  2  1|             
      Inflammation                         |                                           1                              |             
      Mineralization                       |                               1              1  2                        |             
      Artery, Inflammation                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2  4              1                    4                          2   |             
      Hyperplasia                          |                               1                    1                     |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                                                          2               |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                   1      |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |    2  2        1  1  1              2     3        1        2        1   |             
      Thrombosis                           |       1                                                                  |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  M  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |    3  1           2  3  1     1     1     4  2                           |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    1                    1        1              1                        |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|             
                                           | 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  1        3     1                 3  1  1  2  2  2        3        2   |             
      Pars Intermedia, Hyperplasia         |                         2                                                |             
      Pars Nervosa, Hyperplasia            |             2                                                            |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1                       1              2                                1|             
      Follicle, Cyst                       |             1        3     3                                             |             
      Follicular Cell, Hyperplasia         |                                                       2                  |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Inflammation                         |                         1                                                |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                3         |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 1  2  4  1  2  2  4  1  2  2  1     1  1  4  1  1  1     1  1     2  1  1|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                         1                                                |             
      Inflammation                         |    2        3  1  2  1  1  1  2  1  2           3     3  1  1  4  1     3|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                4         |             
      Mineralization                       |                               2              2                           |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 4                        |             
      Interstitial Cell, Hyperplasia       |       1  1  1  1  2     1        1  1        1  1        1        2     1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 2  3     3        4  2     2     4     4  1     2  3  3     3  4  2  3   |             

                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +                                                         |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +|             
      Atrophy                              |                                                                3         |             
      Ectasia                              |             1                    1                                       |             
      Hyperplasia, Plasma Cell             |          3        4                                                      |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                        3         |             
      Ectasia                              |                                                       2                 3|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|             
                                           | 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Accessory Spleen                     |                                                                          |             
      Congestion                           | 1                    2     1  1        1              2     1  1  1  3  2|             
      Fibrosis                             |       1                       2                                          |             
      Hematopoietic Cell Proliferation     | 1  2  2           3  2     1  1  1     1  1     1     1     1     2  2  1|             
      Infiltration Cellular                |                                     1                                    |             
      Pigmentation                         |                   1  1     1  2           2  3  3     1        2        1|             
      Capsule, Hyperplasia                 |                                                                          |             
      Lymphoid Follicle, Atrophy           |          3                          2        3                 2  2      |             
      Red Pulp, Depletion Cellular         |                         2           3                                    |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  M  +  M  M  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Atrophy                              | 3     4  4        4           4  2  4  3  4  4  4  3  4        4  4  4  4|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                      1           2  3               |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   4                                                      |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                      2        1           1  2  2                        |             
      Fracture                             |                                  X                                       |             
      Osteomalacia                         |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                  +                                       |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                  +                                       |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                            2                                             |             
      Hemorrhage                           |                                              1           3               |             
      Inflammation                         |       2        1     1     3     1        1                             1|             
      Mineralization                       |                      1        2              3  2                        |             
      Pigmentation                         |                                     1                                1  1|             
      Alveolar Epithelium, Hyperplasia     |                      1                                               1  1|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          X                 X                       X                     |             
      Inflammation                         |       2  4                                         2                     |             
      Respiratory Epithelium, Inflammation |                   4        3                                             |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 5| 6| 7| 4| 6| 4| 6| 7| 7| 6| 6| 6| 7| 6| 7| 0| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 0| 2| 3| 0| 3| 8| 2| 2| 8| 8| 9| 2| 2| 4| 7| 8| 3| 3| 2| 6| 9| 3| 3|             
                                           | 9| 0| 3| 4| 0| 7| 7| 2| 9| 1| 0| 4| 0| 9| 4| 1| 1| 4| 0| 8| 9| 1| 9| 0| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3750 PPM                               | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        | 1                                                  1        1  1     1  1|             
      Cyst                                 |             1        2  1           2     2  1  2     1                  |             
      Hydronephrosis                       |                                                                4  2      |             
      Infarct                              |       2                                                                  |             
      Inflammation                         |                                     1                          4         |             
      Mineralization, Diffuse              |                               2              2  2              1         |             
      Nephropathy                          | 2  4  4  2  4  1  4  4  4  4  4  2  4  3  4  4  4  2  3  2  3  2  2  2  3|             
      Pigmentation                         |             1  1     1  1  1        1  1  1        1  1  1  1        1  2|             
      Medulla, Mineralization              | 2  1  1  2  1  2  2  2  1  1  2  1  1  2  1  1  1  2  1  2  1     2  1  1|             
      Renal Tubule, Hyperplasia            |                                                 3                       4|             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
      Transitional Epithelium, Hyperplasia | 1  2  1  1  2  1  2  2  2  1  1  1  1  3  1  2  2  1  1  1  4     1  1  2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
      Inflammation                         |                         1                                            1  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4|            |
                                           | 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3750 PPM                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                     X        X                           |      3     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                    3                     |      2  2.0|
      Mineralization                       |                                                    4                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |    2                                                                     |      1  2.0|
      Inflammation                         |       1                                         2                        |      2  1.5|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                             2            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                1                                            1     1  1  1|      9  1.0|
      Basophilic Focus                     |    X     X  X     X  X  X                 X  X  X        X     X  X  X   |     23     |
      Clear Cell Focus                     |          X        X  X        X                                          |      5     |
      Degeneration, Cystic                 | 1  1  1  1  1              1     2        1  2     1  1     1  1  1     1|     29  1.1|
      Eosinophilic Focus                   | X        X     X  X     X     X  X  X  X  X  X  X        X     X         |     20     |
      Hepatodiaphragmatic Nodule           | X                                                                        |      4     |
      Inflammation                         | 1           1  1  1  1        1     1  1  1  1  1     1  1  1  1         |     27  1.0|
      Mixed Cell Focus                     |          X                       X  X  X  X                    X         |     10     |
      Necrosis                             |                   1        4                          1              1   |      5  1.8|
      Thrombosis                           |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            | 1  2     1           1        1     1  1  1  1  1        1     1         |     23  1.2|
      Bile Duct, Hyperplasia               | 1     1  2  1  1  1  1  1  2  1  1  1  1  1  2  1  3  1  1  1  1  1  1  1|     47  1.3|
      Centrilobular, Degeneration          |                                                                   2      |      2  2.0|
      Centrilobular, Hypertrophy           | 1     1     1  1  1  1  1     1  1     1  1     1        1  1  1         |     29  1.1|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +     +              +      |   6        |
      Artery, Mineralization               |                                                    3                     |      2  3.0|
      Fat, Necrosis                        |                                              3                    3      |      4  3.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                      +   |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    1     1  2     1           1     2  1        1  1     1     1     1   |     24  1.2|
      Hyperplasia                          |             1                                                            |      1  1.0|
      Hypertrophy, Focal                   |                                                          1               |      2  1.0|
      Artery, Hypertrophy                  |                                                                          |      1  4.0|
      Artery, Inflammation                 |                            1              2                 3            |      5  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4|            |
                                           | 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3750 PPM                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Artery, Mineralization               |                                                                          |      3  2.0|
      Duct, Cyst                           |                                                                1         |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |       3                                               4                  |      3  3.0|
      Hyperplasia                          |       2                                               3                  |      4  2.3|
      Inflammation                         |             1                                                            |      1  1.0|
      Mineralization                       |                                                    1                     |      4  1.5|
      Ulcer                                |    3  4                                               4                  |      3  3.7|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  1.0|
      Hyperplasia                          |       1                                                                  |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |             4                                      4                     |     10  2.8|
      Ulcer                                |    1           1                                                         |      3  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             3                                      4                     |      7  3.1|
      Aorta, Aneurysm                      |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     1  1  2  1     1  1  1        1     1  1  1  2     1  1  1  1  1  1|     41  1.3|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |             2                                      1                     |      5  1.4|
      Artery, Inflammation                 |                         1                                                |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |          1              1     1                                   1      |      9  1.9|
      Hyperplasia                          |          1           2                       1  1                        |      6  1.2|
      Hypertrophy                          |                                                             1            |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Thrombosis                           |       1                                                                  |      1  1.0|
      Vacuolization Cytoplasmic            |    3        1                                                     1      |      4  1.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2                                                            |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4|            |
                                           | 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3750 PPM                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |       1     2     4     1                                      1         |     15  1.7|
      Thrombosis                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Focal                   |                      4                                                   |      1  4.0|
      Hyperplasia                          |             2                                   1  4                     |     12  2.1|
      Inflammation                         |                                                                   1      |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        4                                 |      1  4.0|
      Cyst                                 | 1                                         2                              |      6  1.2|
      Pars Distalis, Hyperplasia           |       1                 1     2        4                 4  2  1         |     19  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      C-Cell, Hyperplasia                  |    2     1  1     1           1  1                          1  3         |     12  1.3|
      Follicle, Cyst                       |                2                                                         |      4  2.3|
      Follicular Cell, Hyperplasia         |                   1                                               1      |      3  1.3|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                       2                  |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|
      Mineralization                       |             4                                                            |      1  4.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                         2                                                |      1  2.0|
      Inflammation                         |    1  1  1     1     1  1  1  1  1  1  2  1  1  1  1  1  2  1  1     2  1|     43  1.4|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                   2      |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation                         | 2  4  3     1  1     1        1  2     2  4  1  1     2     1  4     1  2|     34  1.9|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  4.0|
      Mineralization                       |             3                                                            |      3  2.3|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             4                          4        4     4                  |      5  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4|            |
                                           | 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3750 PPM                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       | 1  1        1  2           1     1              1  1  1  1     2  1  1   |     26  1.2|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           1                              |      1  1.0|
      Hyperplasia                          | 3        3  3     1  1  2  3  2     2  2     1  1  3     2  2     3  3   |     33  2.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |                                        1                             2   |      4  1.3|
      Hyperplasia, Plasma Cell             |                                                                      3   |      3  3.3|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      2  3.0|
      Ectasia                              |    2                 2  2           2           2                        |      7  2.1|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                      X   |      1     |
      Congestion                           | 2  1  1  2  1     2  2  2     3     2  1  2  2  2  1  1  2  2  2     2   |     31  1.6|
      Fibrosis                             |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     | 1  2     2  2  1  1  1  1  2  1     1  1  1  1  1  1  3  1  2  1  2  2  1|     39  1.4|
      Infiltration Cellular                |                                                                          |      1  1.0|
      Pigmentation                         | 1  2  2  1  2  1  1  2  1              1  1  2  1  2  1  1  1  1         |     28  1.5|
      Capsule, Hyperplasia                 |                               1                                          |      1  1.0|
      Lymphoid Follicle, Atrophy           |                                                    3                     |      6  2.5|
      Red Pulp, Depletion Cellular         |                                                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Atrophy                              | 4  4  4  3  4  3  2  4  4  4  3     3  3  3  4  4  4  4  3  3  3  4  4  4|     41  3.6|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |    2                 4           1                    2  2     1         |     10  1.9|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                         4                                                |      2  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |       1     1              1                       2                     |      9  1.4|
      Fracture                             |                                                                          |      1     |
      Osteomalacia                         |    1        2                                                            |      3  1.7|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4|            |
                                           | 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3750 PPM                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                         3|      1  3.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                         +|   2        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                         +|   2        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation                         |             3  2                 1  1  2  1        1                     |     14  1.5|
      Mineralization                       |             2                                      2                     |      6  2.0|
      Pigmentation                         |                                                 1     1                  |      5  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |          X  X     X                                                      |      6     |
      Inflammation                         |          1  2     2                                                      |      6  2.2|
      Respiratory Epithelium, Inflammation |                2                                                         |      3  3.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                2                                                         |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   2        |
      Inflammation                         |             3                                                            |      1  3.0|
      Mineralization                       |             3                                                            |      1  3.0|
      Retina, Degeneration                 |             2                                                            |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                1  1           1  2  1     1  1                 1  2     1|     16  1.1|
      Cyst                                 |    1        1                                   2           1     2      |     13  1.5|
      Hydronephrosis                       |                                                                          |      2  3.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation                         |                         1              1                                 |      4  1.8|
      Mineralization, Diffuse              |             3                                      2                     |      6  2.0|
      Nephropathy                          | 3  4  4  2  4  2  3  3  3  2  3  2  2  3  2  2  3  4  4  3  2  2  2  4  3|     50  3.0|
      Pigmentation                         | 1  1     1        1  1        1  1  1  1  1  1  1  1  1  1  1  1     1  1|     33  1.0|
      Medulla, Mineralization              | 1  1  3  2  1  1  1  1  3  3  3  1  3  2  1  1  2  2  2  2  2  1  2  1  2|     49  1.6|
      Renal Tubule, Hyperplasia            |       1     1                 2     2     1              1     1         |      9  1.8|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88036-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:51:10  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 2| 6| 9| 7| 4| 6| 3| 2| 2| 0| 3| 3| 2| 2| 2| 3| 2| 9| 0| 2| 9| 2| 9| 9| 4|            |
                                           | 9| 7| 0| 7| 6| 6| 0| 9| 9| 7| 0| 0| 9| 9| 9| 0| 9| 7| 5| 9| 0| 9| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    3750 PPM                               | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|      L     |
                                           | 0| 1| 2| 3| 4| 5| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Hyperplasia, Oncocytic |    1                                                                     |      1  1.0|
      Transitional Epithelium, Hyperplasia | 2  1  2  2  1     1  1  2  1  1  1  2  2  1  1  2  1  1  2  1  1  1  1  1|     48  1.4|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                   1     1     1  1                       1        1      |      9  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------