Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/4788

TDMS Study 88036-04 Pathology Tables

NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98
Route: DOSED FEED                                                                                                 Time: 08:59:08

                                                      2 YEAR CHRONIC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  84-65-1

       Lock Date:  07/01/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9            5            8            5                                     
    Moribund Sacrifice                                 6            3            4            2                                     
    Accidently Killed                                                            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           42           35           42                                     
  Missing                                                                                     1                                     

  Animals Examined Microscopically                    50           50           50           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)                                   
   Liver                                              (49)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatoblastoma                                                                          1 (2%)                                
      Hepatocellular Carcinoma                         2 (4%)       1 (2%)       7 (14%)      6 (12%)                               
      Hepatocellular Carcinoma, Multiple                            2 (4%)       1 (2%)       2 (4%)                                
      Hepatocellular Adenoma                           5 (10%)     11 (22%)     14 (28%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)      17 (34%)     13 (26%)     30 (61%)                               
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       2 (4%)                                             
      Ito Cell Tumor Malignant                         1 (2%)                                                                       
   Mesentery                                          (6)          (4)          (6)          (7)                                    
      Histiocytic Sarcoma                                                        1 (17%)                                            
   Pancreas                                           (50)         (50)         (50)         (49)                                   
   Salivary Glands                                    (49)         (49)         (50)         (49)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Papilloma                          3 (6%)                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (49)         (49)                                   
      Pheochromocytoma Malignant                                                              1 (2%)                                
   Pituitary Gland                                    (47)         (50)         (48)         (46)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Pars Distalis, Adenoma                           4 (9%)       7 (14%)      4 (8%)       6 (13%)                               
   Thyroid Gland                                      (45)         (48)         (48)         (48)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Follicular Cell, Carcinoma                                                              2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (45)         (50)         (49)         (49)                                   
      Cystadenoma                                      2 (4%)                    2 (4%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Leiomyoma                                                                  1 (2%)                                             
      Polyp Stromal                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (5)          (2)          (4)          (4)                                    
      Lumbar, Histiocytic Sarcoma                      1 (20%)                                                                      
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                   1 (25%)                               
   Lymph Node, Mandibular                             (48)         (46)         (48)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (50)         (49)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (45)         (49)         (48)         (48)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                                        2 (4%)                                             
   Thymus                                             (44)         (47)         (46)         (44)                                   
____________________________________________________________________________________________________________________________________
NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (48)         (48)         (49)                                   
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (49)                                   
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                    (3)          (2)          (2)          (1)                                    
      Fibrosarcoma, Metastatic, Skin                   1 (33%)      1 (50%)      1 (50%)                                            
      Rhabdomyosarcoma                                                                        1 (100%)                              
      Sarcoma, Metastatic, Skin                                     1 (50%)      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Spinal Cord                                        (2)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       2 (4%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   3 (6%)                                 3 (6%)                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                                        2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (4)          (4)          (1)                                    
      Adenoma                                          2 (100%)     3 (75%)      4 (100%)     1 (100%)                              
      Carcinoma                                                     1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (49)         (49)                                   
      Histiocytic Sarcoma                                                        2 (4%)                                             
   Urinary Bladder                                    (44)         (48)         (46)         (48)                                   
      Hemangioma                                                    1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(49)                                   
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Lymphoma Malignant                              14 (28%)      8 (16%)      8 (16%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            28          38          41          44                                       
     Total Primary Neoplasms                           45          63          63          82                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 13          31          32          40                                       
     Total Benign Neoplasms                            19          41          43          54                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          17          18          25                                       
     Total Malignant Neoplasms                         26          22          20          28                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4           3           1                                       
     Total Metastatic Neoplasm                          1           4           3           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            6            4           19                                     
    Moribund Sacrifice                                 3            3            3            8                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           41           43           23                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
   Liver                                              (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Hepatoblastoma                                   1 (2%)       5 (10%)     11 (22%)     21 (43%)                               
      Hepatoblastoma, Multiple                                      1 (2%)                   16 (33%)                               
      Hepatocellular Carcinoma                         7 (14%)      9 (18%)     12 (24%)     12 (24%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       4 (8%)       5 (10%)      9 (18%)                               
      Hepatocellular Adenoma                          16 (32%)     10 (20%)     10 (20%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                 5 (10%)     22 (44%)     28 (56%)     31 (63%)                               
      Hepatocholangiocarcinoma                                      1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       2 (4%)       1 (2%)                                
   Mesentery                                          (2)          (2)          (1)          (5)                                    
   Oral Mucosa                                                                               (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Capsule, Adenoma                                                                        1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (50)         (49)                                   
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (42)                                   
NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (48)         (48)         (47)         (46)                                   
      Pars Distalis, Adenoma                                                     1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)         (46)                                   
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicular Cell, Adenoma                                                   2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (49)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (1)          (1)          (3)                                                 
      Mediastinal, Histiocytic Sarcoma                                           1 (33%)                                            
   Lymph Node, Mandibular                             (48)         (45)         (44)         (48)                                   
   Lymph Node, Mesenteric                             (49)         (49)         (47)         (40)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (50)         (49)         (42)                                   
      Hemangiosarcoma                                  2 (4%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Thymus                                             (45)         (48)         (40)         (42)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (49)                                   
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                                  2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Schwannoma Malignant, Metastatic, Skin                                     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    10 (20%)      7 (14%)      6 (12%)      8 (16%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   8 (16%)     11 (22%)      8 (16%)      3 (6%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)       3 (6%)       1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)       8 (16%)                               
      Hepatocellular Carcinoma, Metastatic, Liver      4 (8%)       1 (2%)       2 (4%)       5 (10%)                               
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (4)          (4)          (4)                                    
      Adenoma                                          3 (100%)     4 (100%)     4 (100%)     4 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (2%)       2 (4%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)       2 (4%)       1 (2%)                                
      Lymphoma Malignant                               3 (6%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   9                                                               
NTP Experiment-Test: 88036-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 12/11/98  
Route: DOSED FEED                                                                                                 Time: 08:59:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        833 PPM      2500 PPM     7500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          38          47          48                                       
     Total Primary Neoplasms                           62          82         102         126                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27          34          41          43                                       
     Total Benign Neoplasms                            37          46          56          57                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          28          33          45                                       
     Total Malignant Neoplasms                         25          36          46          69                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2           4          12                                       
     Total Metastatic Neoplasm                          4           4           4          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------