TDMS Study 88050-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Columbus METHACRYLONITRILE DATE: 10/19/99 EXPERIMENT: 88050 TEST: 06 TIME: 12:52:11 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: NO1-ES-55388 ROUTE: GAVAGE NTP C#: 88050B PATHOLOGIST: TOFT, JOHN CAS: 126-98-7 ------------------------------------------------------------------------------------------------------------------------------------ CORE STUDY MICE FINAL#1 REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Columbus METHACRYLONITRILE DATE: 10/19/99 EXPERIMENT: 88050 TEST: 06 TIME: 12:52:11 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: NO1-ES-55388 ROUTE: GAVAGE NTP C#: 88050B PATHOLOGIST: TOFT, JOHN CAS: 126-98-7 METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 0 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 1 TERMINAL 35 | | | | UNCENSORED DEATHS | | 501 513 583 600 638 650 663 670 677 694 | | 694 694 709 712 | | CENSORED DEATHS | | 73 | | | |--------------------------------------------------------------------------------| | DOSE = 1.5 MG/KG | | ---------------------------- | | | | TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 | | | | UNCENSORED DEATHS | | 563 605 625 625 629 644 714 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 3 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 | | | | UNCENSORED DEATHS | | 429 439 502 612 655 694 703 | | CENSORED DEATHS | | NONE | | | ================================================================================== METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 6 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 3 CENSORED DEATHS 25 TERMINAL 22 | | | | UNCENSORED DEATHS | | 621 623 710 | | CENSORED DEATHS | | 3 481 481 481 481 481 481 481 481 481 | | 481 481 481 481 481 481 481 481 481 481 | | 481 481 481 481 481 | | | ================================================================================== METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 729 (A) | | | |--------------------------------------------------------------------------------| | | | |0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 95.9 91.8 85.7 71.4 | | | | | | | |1.5 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 96.0 88.0 86.0 | |MG/KG | | | | | |3 MG/KG | 100.0 100.0 100.0 100.0 100.0 96.0 94.0 94.0 90.0 86.0 | | | | | | | |6 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.0 88.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 0 MG/KG 1.5 3 MG/KG 6 MG/KG | | MG/KG | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 71.4% 86.0% 86.0% 88.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.099N P=0.139N P=0.143N P=0.191N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 642.7 629.3 576.3 651.3 | |NATURAL DEATHS (C) | (18.4) (17.2) (44.6) (29.3) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 691.7 715.0 707.6 590.8 | |(STANDARD ERROR) | (14.7) ( 5.4) ( 9.6) (20.9) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 730 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 0 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 | | | | UNCENSORED DEATHS | | 362 492 593 607 623 625 645 653 662 668 | | 671 687 704 709 727 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 1.5 MG/KG | | ---------------------------- | | | | TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 | | | | UNCENSORED DEATHS | | 289 374 405 422 476 521 556 568 638 644 | | 667 709 711 721 722 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 3 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 | | | | UNCENSORED DEATHS | | 533 589 589 602 653 701 716 | | CENSORED DEATHS | | NONE | | | ================================================================================== METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 730 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 6 MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 15 TERMINAL 25 | | | | UNCENSORED DEATHS | | 212 308 343 581 641 641 673 694 703 714 | | CENSORED DEATHS | | 480 480 480 480 480 480 480 480 480 480 | | 480 480 480 480 480 | | | ================================================================================== METHACRYLONITRILE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 730 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 730 (A) | | | |--------------------------------------------------------------------------------| | | | |0 MG/KG | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 94.0 82.0 70.0 | | | | | | | |1.5 | 100.0 100.0 100.0 98.0 92.0 90.0 88.0 84.0 80.0 70.0 | |MG/KG | | | | | |3 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 90.0 86.0 | | | | | | | |6 MG/KG | 100.0 100.0 98.0 94.0 94.0 94.0 94.0 91.1 85.2 73.4 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 0 MG/KG 1.5 3 MG/KG 6 MG/KG | | MG/KG | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 70.0% 70.0% 86.0% 73.4% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.563N P=1.000 P=0.097N P=0.978N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 628.5 561.5 626.1 551.0 | |NATURAL DEATHS (C) | (24.1) (36.6) (25.1) (59.6) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 699.6 679.5 715.5 619.2 | |(STANDARD ERROR) | ( 9.7) (15.4) ( 6.1) (19.8) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) METHACRYLONITRILE KAPLAN-MEIER SURVIVAL CURVES 0 MG/KG = 1 1.5 MG/KG = 2 3 MG/KG = 3 6 MG/KG = 4 ------------------------------------------------------ SPECIES=MICE SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 3 1 2 4 | | 33 1 1 2 2 | 3 3 1 1 2 2 P 95 + E | 3 1 1 3 R | 34 3 4 C | 1 1 E 90 + 2 113 3 N | T | 21 1 332 4 | 11 32 2 S 85 + U | 11 R | V | 1 1 I 80 + V | A | L | 75 + 1 1 | | | 1 1 70 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 6 obs hidden. METHACRYLONITRILE KAPLAN-MEIER SURVIVAL CURVES 0 MG/KG = 1 1.5 MG/KG = 2 3 MG/KG = 3 6 MG/KG = 4 ----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 4 2 1 3 | | 4 2 4 1 2 1 3 3 | 4 4 2 2 1 1 P 95 + E | 4 2 2 4 131 R | 2 2 31 1 3 C | 4 4 E 90 + 2 2 11 3 3 N | T | 2 2 1 1 3 3 | 2 2 11 3 3 S 85 + 4 4 U | 2 2 1 1 R | 114 4 V | I 80 + 2 2 V | 44 A | 1 1 2 L | 1 14 75 + | 112 4 | 121 | 70 + 1 1 | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 11 obs hidden.