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TDMS Study 88120-03 Pathology Tables

NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99
Route: DOSED FEED                                                                                                 Time: 12:57:41

                                                    FINAL #1 CORE STUDY RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  80-07-9

       Lock Date:  08/11/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1



NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2|             
                                           | 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                 X           X        X         |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                        2                                 |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X  X     X  X  X  X|             
      Clear Cell Focus                     |                   X                                                      |             
      Eosinophilic Focus                   |       X        X     X                                   X        X      |             
      Fatty Change                         |             4                                                            |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X           X              X                          X|             
      Inflammation                         | 1  1  1  1     1  1  1  1  1     1  1  1     2  1  1  1  1        1  1  1|             
      Mixed Cell Focus                     |                   X              X                                       |             
      Necrosis                             |                                                             4            |             
      Vacuolization Cytoplasmic            |                                     1        1                           |             
      Bile Duct, Hyperplasia               |             1                             2                 2            |             
      Centrilobular, Degeneration          |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                               +                          +  +            |             
      Fat, Necrosis                        |                               3                          3               |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1                             1        1        1                  |             
      Inflammation                         |    1                             1                                   1   |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                                                            |             
      Cytoplasmic Alteration               |                                                                      1   |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                             1            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        1                    1            |             
      Inflammation                         |                                                                          |             
      Ulcer                                |             1                             1                              |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1  1           1  1  1     1              1     1  1           1  1|             
      Inflammation                         |                1                                   1              1      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2|             
                                           | 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1     1     1           1                 1  1                    2   |             
      Degeneration, Cystic                 |                               1                                2         |             
      Hyperplasia                          |                1  1                          2     1              1  1   |             
      Hypertrophy                          |                1                 1                                       |             
      Vacuolization Cytoplasmic            |                      1        4                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1        2  1            |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2        2        4        2     2     1     2           2           2  3|             
      Cyst                                 |                                           1                              |             
      Pars Distalis, Hyperplasia           |          4  1           3        4           2     1  1     3  1  2  1  2|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   3      |             
      C-Cell, Hyperplasia                  | 1  1  1  1     1  1     1  1  1  1     1     1  1  1  3  1        1  1   |             
      Follicular Cell, Hyperplasia         |                                     1                                    |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Hyperplasia                          |                1        1        2                                       |             
      Inflammation                         |                   1        1  1  1  1     1        1              1      |             
      Duct, Cyst                           | 1              3                                                         |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                            3  4                                          |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                    2        4            |             
      Cervix, Inflammation                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                       1                  |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1        4     2           2  3         |             
      Myelofibrosis                        |                               3                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +           +  +     +  +  +           +     +     +  +  +|             
      Mediastinal, Pigmentation            |          1     1           1  1     1  2              1     1     1  2  2|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2|             
                                           | 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                             4  3         |             
      Pigmentation                         |    2     2     2     1              3  2     1     2     2        1     2|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
      Atrophy                              | 4  4     3  4  4  4  3  3  3  4  4  4  3  3     3  4  3  3  4     4  3  4|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Galactocele                          |                                              2                           |             
      Hyperplasia                          |       1     2     2              1        1           1  1  1            |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        | 4                                                                        |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               1           1                              |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                        +                                 |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1     1  1     1  1                    1     1  1  1     1     1|             
      Pigmentation                         | 1  1  1              1  1  1  1  1  1  1     1  1  1  1  1  1     1  1  1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                      X   |             
      Inflammation                         |                                     1                                1   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                               3                                          |             
      Retina, Degeneration                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 6| 5| 4| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2|             
                                           | 0| 1| 0| 2| 1| 0| 0| 3| 2| 2| 2| 2| 5| 6| 3| 1| 0| 1| 0| 2| 4| 9| 2| 2| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                             2            |             
      Inflammation                         |                                  2                                       |             
      Nephropathy                          | 1  2  1  1  1  1  1  1     1  1     1     1     1        1  1     1     1|             
      Pigmentation                         |                               1                                          |             
      Pelvis, Inflammation                 |                                                                      2   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                        X                                 |             
      Transitional Epithelium, Hyperplasia |                                        4                                 |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3|            |
                                           | 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                               X                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                  X  X  X                 X               |      8     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     47     |
      Clear Cell Focus                     |                X                                                         |      2     |
      Eosinophilic Focus                   | X                    X        X        X                                 |      9     |
      Fatty Change                         |                                                                          |      1  4.0|
      Hemorrhage                           |                                     2                                    |      1  2.0|
      Hepatodiaphragmatic Nodule           |                         X              X  X        X                    X|      9     |
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1     1  1  1  1  1  1     1|     43  1.0|
      Mixed Cell Focus                     |                X  X                                            X  X  X  X|      8     |
      Necrosis                             |    1                                2                                    |      3  2.3|
      Vacuolization Cytoplasmic            |                      1     1           2                          1  1   |      7  1.1|
      Bile Duct, Hyperplasia               |                                        1                                1|      5  1.4|
      Centrilobular, Degeneration          |                                                             1            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |             +           +           +                                   +|   7        |
      Fat, Necrosis                        |             3           3           3                                   3|      6  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1        1  1  1                                   1        1            |     10  1.0|
      Inflammation                         |                                                       1           1      |      5  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                                                               |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      2  1.0|
      Inflammation                         |                                                             3            |      1  3.0|
      Ulcer                                |                                                             3            |      3  1.7|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3|            |
                                           | 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1  1  1     1  1  1  1  1  1  1     1  1     1  1        1  1  1  1|     30  1.0|
      Inflammation                         |                                        1     1                           |      5  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    1  2  2  1  1  1  2  1     1  2  1  1  1  2     1  2  1     2  1      |     27  1.3|
      Degeneration, Cystic                 |                            1                                             |      3  1.3|
      Hyperplasia                          | 1  3     1  1     1                                1     1           1   |     14  1.2|
      Hypertrophy                          | 2                                                        3               |      4  1.8|
      Vacuolization Cytoplasmic            |                            1                                             |      3  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           3                              |      4  1.8|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       3  2           2           2     2  1  2        2           2      |     19  2.1|
      Cyst                                 |       2              1                 1                                 |      4  1.3|
      Pars Distalis, Hyperplasia           |             2  2     3           2     3  3     1     4  2        2     2|     23  2.2|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  | 1  3  4  1        1  1  1  1  1  1  2     1  4     1  1        3        1|     35  1.4|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |       2  2                                   2                           |      6  1.7|
      Inflammation                         |       1  2     4  1                          3     1        1  2         |     16  1.4|
      Duct, Cyst                           |          3                                                               |      3  2.3|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    4                       3                                             |      2  3.5|
      Cyst                                 |                               3                                          |      3  3.3|
      Inflammation                         |                            3                                             |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3|            |
                                           | 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrometra                           |                                                                          |      2  3.0|
      Cervix, Inflammation                 |                                                                   4      |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                   1                                      2               |      3  1.3|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3                       3  2                             3            |      9  2.6|
      Myelofibrosis                        |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +  +     +     +  +     +  +  +  +  +           +  +  +   |  27        |
      Mediastinal, Pigmentation            |    1        1  1  1     2     1  1     2  1  1  1  1           1  2  1   |     26  1.2|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Ectasia                              |                                           1                              |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3                                                                     |      1  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    3                                                                     |      3  3.3|
      Pigmentation                         | 1           1  1  1              1  2  2  2  2  2  2           1  1  1   |     25  1.6|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Atrophy                              | 3  4  4  4  3  3  3  3  3  3  3  3  3  3  4  3  2  3  4     4  4  3  3  3|     46  3.4|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                            2        2                                    |      2  2.0|
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          |    2     1                    1  1        1                       1      |     14  1.2|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                         4                                                |      2  4.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  1.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 6| 0| 3| 3| 1| 3|            |
                                           | 0| 5| 0| 1| 0| 0| 0| 1| 5| 0| 1| 2| 1| 2| 1| 2| 4| 0| 1| 0| 1| 1| 0| 3| 1|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         | 1  1           1     1  1        1     1     1           1        1  1   |     23  1.0|
      Pigmentation                         | 1  1  1  1  1  2  1  1  1     1  1  1  1     1     1  1  1     1  1  1  1|     40  1.0|
      Alveolar Epithelium, Hyperplasia     |    1     1  2     1        1        1  1     1                           |      8  1.1|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    X                                                                     |      2     |
      Inflammation                         |    2                                                                     |      3  1.3|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      1                                                   |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |    +                       +                                             |   3        |
      Cataract                             |                            3                                             |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Retina, Degeneration                 |                            3                                             |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Nephropathy                          | 1     1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1|     39  1.0|
      Pigmentation                         |    1                                1                    1  2            |      5  1.2|
      Pelvis, Inflammation                 |                                                    1                     |      2  1.5|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3|             
                                           | 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                   X         |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X     X  X|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                      X           X     X  X                          X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              X     X              X      |             
      Inflammation                         | 1  1  1  1     1  1  1  1        1  1  2  1  1  1  1  1  1  1     1  1  1|             
      Mixed Cell Focus                     | X     X              X           X  X  X  X              X              X|             
      Vacuolization Cytoplasmic            |                                              1  1  2                    1|             
      Bile Duct, Hyperplasia               |             2        1  1  1  1     1  1                       1         |             
      Centrilobular, Degeneration          |             2              2  2                                3         |             
      Centrilobular, Hypertrophy           |                                                    2                     |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +     +                                +      |             
      Inflammation                         |                                                                   3      |             
      Artery, Inflammation                 |                                                                   3      |             
      Fat, Necrosis                        |       3                    3     2                                       |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1        3     1              1                          1   |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                     1                                   1|             
      Thrombosis                           |                                                                   4      |             
      Artery, Inflammation                 |                                                                   3      |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     1                                    |             
      Cytoplasmic Alteration               |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1                     |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                              1                           |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                    2                     |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3|             
                                           | 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   2      |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           1  1     1  1        1  1  1        1           1  1         |             
      Inflammation                         |    1                                                                 1   |             
      Thrombosis                           |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2  2        1  1        1  1  1                       1        2   |             
      Degeneration, Cystic                 | 2                                                                        |             
      Hyperplasia                          |                1           1           1     1        1                  |             
      Hypertrophy                          |          2              1                                                |             
      Vacuolization Cytoplasmic            |                                  1                 3                     |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                  1        1     1              1         |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2        2  1                    1     2     2  2     2           4|             
      Cyst                                 |    2  2                                               1  2               |             
      Pars Distalis, Hyperplasia           | 2  2  1  3  1  2  1        3     1  2              2  4  2     3     2  4|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      C-Cell, Hyperplasia                  | 1  1     2  1  2  1  1  1  1  1  1  1  1  1  1  1     3  2  1           1|             
      Follicular Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2     2        3                                          |             
      Inflammation                         |                         1     2  1     1     1                       1  1|             
      Duct, Cyst                           |                4              3                                2  2      |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
      Cyst                                 |    3                             3  2                                   4|             
      Infiltration Cellular, Histiocyte    |                                     4                                    |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2                        |             
      Endometrium, Hyperplasia, Cystic     |                                           1           2        1        3|             

                                            __________________________________________________________________________|             
   Vagina                                  |                                                    +                     |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3|             
                                           | 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                    2                     |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 3  1     2                 2                                   2  3      |             

                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +              +  +           +     +           +  +  +     +|             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                   3      |             
      Mediastinal, Pigmentation            |       1  2                 1  2           2     2           2           1|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             1              1                 1              1            |             
      Hyperplasia, Plasma Cell             |       3                                      3                           |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                   3      |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                    2              3      |             
      Pigmentation                         |                         1        1  2  2     1  2        1  2           1|             
      Capsule, Fibrosis                    |                                                                   1      |             
      Lymphoid Follicle, Atrophy           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     4  3     3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     4  3  3|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                    1  2     1  1  1     1              1  3     4|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation    |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |       2                                                                  |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                2         |             
      Inflammation                         |    1  2  1  1  1  1  1                 1     1        1     1            |             
      Pigmentation                         | 1     1  1  1  1     1  1  1  1  1  1  1  1  1  1  1     1  1           1|             
      Thrombosis                           |                                                                4         |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 4| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 3| 6| 3| 3| 3| 9| 5| 3| 3|             
                                           | 2| 1| 0| 2| 0| 1| 1| 0| 2| 0| 9| 2| 2| 1| 2| 0| 0| 6| 1| 2| 2| 0| 1| 3| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |             
      Bronchiole, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1                                                            |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                   +                             +                        |             
      Cataract                             |                   3                             2                        |             
      Retina, Degeneration                 |                   4                             3                        |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                                                                          |             
      Inflammation                         |                                                             1            |             
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1           1|             
      Pigmentation                         |             1                 1                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pelvis, Inflammation                 |                      1                                                   |             
      Renal Tubule, Hyperplasia            |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Fibrosis                     |                                                                   2      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    30 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                  X        X                              |      4     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                       3                  |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                1                                                         |      1  1.0|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     48     |
      Clear Cell Focus                     |                   X           X                             X  X     X   |      5     |
      Eosinophilic Focus                   |                      X     X        X                          X        X|     10     |
      Hematopoietic Cell Proliferation     | 1                                                                        |      1  1.0|
      Hepatodiaphragmatic Nodule           |       X              X  X           X           X     X           X     X|     11     |
      Inflammation                         | 1  1  1  1  1  2  1  1     1  1  1  2  1  1  1  1  1  1     1  1  1  1  2|     44  1.1|
      Mixed Cell Focus                     |          X  X  X     X        X  X  X        X  X                       X|     19     |
      Vacuolization Cytoplasmic            |                   1     1        1                 1  2        1        1|     11  1.2|
      Bile Duct, Hyperplasia               |       1     1                                            1        1      |     12  1.1|
      Centrilobular, Degeneration          |                                                          1               |      5  2.0|
      Centrilobular, Hypertrophy           |                1                                                         |      2  1.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                    +        +           +      |   8        |
      Inflammation                         |                                                       2                  |      2  2.5|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Fat, Necrosis                        |                         3                    2                    3      |      6  2.7|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             1                    1                             1         |      8  1.3|
      Hyperplasia                          |                                                             1            |      1  1.0|
      Inflammation                         |                                                                          |      2  1.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|
      Cytoplasmic Alteration               |                                           1                              |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    30 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation                         |                                                       2                  |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |             +                                                            |   2        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       1        1  1     1  1     1     1     2           2  1  2     1   |     23  1.1|
      Inflammation                         |                      1                    1                              |      4  1.0|
      Thrombosis                           |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       2  1  2     1  1  1  1  1  1                 2                    1|     21  1.3|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          |             1     1           1  1  1        1                           |     11  1.0|
      Hypertrophy                          |                      1  1                                                |      4  1.3|
      Vacuolization Cytoplasmic            |                                              1        3  2        1      |      6  1.8|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                1  2                 1                 1                  |      8  1.1|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |       1        2  1           2        3     2  2                    1   |     17  1.9|
      Cyst                                 |                                                                          |      4  1.8|
      Pars Distalis, Hyperplasia           | 1              4  1  3     1     1     3     1  2     3  1           1   |     28  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              1                           |      1  1.0|
      C-Cell, Hyperplasia                  |       1     4  2  1  2  2  1  1  2  1  3  1  1  1  1        1        1  1|     38  1.4|
      Follicular Cell, Hyperplasia         |                                                       3                  |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2                                                           4  1|      6  2.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    30 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |             1  1     2  2  1     1  4  1  1           1                  |     17  1.4|
      Duct, Cyst                           |                               2                                          |      5  2.6|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                    3                     |      2  2.5|
      Cyst                                 |                                  1  3                    4               |      7  2.9|
      Infiltration Cellular, Histiocyte    |       1                                                                  |      2  2.5|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                              2  1                    2   |      7  1.7|

                                            __________________________________________________________________________|____________|
   Vagina                                  | +                                                                        |   2        |
      Hyperplasia                          | 4                                                                        |      1  4.0|
      Inflammation                         | 3                                                                        |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                          3               |      1  3.0|
      Hyperplasia                          | 3  3  3  3                       3                    3                  |     12  2.6|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +           +           +  +  +        +  +  +  +           +  +|  23        |
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |       1  1           1           2  2  2        1  1  2              1  2|     19  1.5|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |       1     1     1  1                                                   |      8  1.0|
      Hyperplasia, Plasma Cell             |       2                                               3                  |      4  2.8|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                       3                  |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 4  2                                                                     |      4  2.8|
      Pigmentation                         |          1  2     2  2  1  1  2     2  1  1  2  1  1        1  1     1  2|     26  1.4|
      Capsule, Fibrosis                    |                                                                          |      1  1.0|
      Lymphoid Follicle, Atrophy           |                                                       2                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 2  2  3  3  3  3  4  3  3     3  3  2  2  3  2  2  3  4  4  3  3  3  3  3|     46  3.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1  1              1  1  1        1        2              1     1|     19  1.4|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation    |                   1                                                      |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 6| 3| 3| 1| 3| 3|            |
                                           | 3| 9| 1| 1| 1| 1| 2| 2| 1| 0| 0| 1| 2| 2| 0| 2| 0| 1| 2| 6| 0| 1| 6| 2| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    30 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                          3               |      2  2.5|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         | 1     1  1        1  1  1                       1           1  1        1|     21  1.0|
      Pigmentation                         |    1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1     1  1|     40  1.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                2     2     2  1                             1  1         |      7  1.6|
      Bronchiole, Hyperplasia              |       1                                                                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                       3                  |      2  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                      1   |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  2.5|
      Retina, Degeneration                 |                                                                          |      2  3.5|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glomerulosclerosis                   |    1                                                                     |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|
      Nephropathy                          |          1  2  2     1  1  1  1  1  1  1  1  1  1  1  2  1  2  2  1  1  1|     43  1.1|
      Pigmentation                         |                                                                          |      2  1.0|
      Vacuolization Cytoplasmic            |                                                       2                  |      1  2.0|
      Pelvis, Inflammation                 |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                                  1                                       |      1  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Serosa, Fibrosis                     |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7|             
                                           | 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X  X                                                   |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X   |             
      Clear Cell Focus                     |                            X                                             |             
      Eosinophilic Focus                   |             X              X        X     X  X     X     X               |             
      Hepatodiaphragmatic Nodule           |                            X  X     X           X  X           X  X     X|             
      Inflammation                         | 1  1  1  1  1     1  1  1  1  1     1     2     1  1     1  1  1  1      |             
      Mixed Cell Focus                     |                         X                                                |             
      Necrosis                             |                                                       2                  |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                                  2                    1                 4|             
      Bile Duct, Hyperplasia               |          1                 1           1        1  1     1     1  1      |             
      Centrilobular, Degeneration          |                2                 3     4              3                 2|             
      Centrilobular, Hypertrophy           |          1  1     1  1  1                 1  2  2           1  1  2  1   |             

                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Fat, Necrosis                        |                               3                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                1                       2     1     1              1      |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation                         |                                     1           1        1               |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           1           1                  |             
      Cytoplasmic Alteration               |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia                          | 3                                                                        |             
      Inflammation                         |                                                                          |             
      Ulcer                                | 1                                                                        |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                | 1                                                     1                  |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7|             
                                           | 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       |    1     1  1        1  1  1  1           1     1  1        1     1     1|             
      Thrombosis                           |                1                                                         |             
      Valve, Inflammation                  |                3                                                         |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2     1  1     1  1     1  1              1  1  1     1  1  1  1      |             
      Degeneration, Cystic                 |                                        1                                 |             
      Hyperplasia                          |                1  1     1  1                    1  1  1  2  1  1         |             
      Hypertrophy                          |                                                                         1|             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |          1  1                    3                                   1  3|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     4                                    |             
      Hyperplasia                          |                                                                         1|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2        1  3  2  1  2           2  2  1     1     2  1     2   |             
      Pars Distalis, Hyperplasia           |          3     1  3  1  3                    4  1     1  1  1  1  4     1|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Pars Nervosa, Hyperplasia            |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4        1  1  1  1  1  1  1  1        1  1  1  1  1     1  1  1  2     2|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                                                               |             
      Inflammation                         |             1  1  1           1     1     1  1  1     2        1         |             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                1                                                        1|             
      Infiltration Cellular, Histiocyte    |    2                                         2                           |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 4                        |             
      Hydrometra                           |                               3                 4                        |             
      Cervix, Cyst, Squamous               |                                           3                              |             
      Cervix, Hydrometra                   |                                                                          |             
      Cervix, Hyperplasia, Squamous        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7|             
                                           | 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cervix, Inflammation                 |                                                             3            |             
      Endometrium, Hyperplasia, Cystic     |                   1                    2           2                     |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                      3        2         |             
      Inflammation, Granulomatous          |                                                                2         |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                            +  +     +  +     +        +  +     +  +  +   |             
      Mediastinal, Pigmentation            |                            1  1     1        1        2  1     2  1  1   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                     1     1  1                           |             
      Hyperplasia, Plasma Cell             |                                                                      3   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                            1                          3              1   |             
      Infarct                              |                                                                          |             
      Pigmentation                         | 2     1     1     1  1  1  1  1     1        1     2     1  1  1         |             
      Lymphoid Follicle, Atrophy           |       2                                                                  |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  4  3  3  2  4  3  3  3  3  3  4  3     4  4  4  4  4  3  3  4  3  4  4|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Galactocele                          |             4        4                                         2        2|             
      Hyperplasia                          |          1  1        1  2              1  1  1                          1|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                            3     4  3     2                          2   |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  1                                       |             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 6| 3| 3| 6| 3| 3| 3| 3| 3| 2| 3| 7| 3| 3| 3| 0| 0| 3| 3| 3| 3| 2| 7|             
                                           | 6| 6| 8| 0| 1| 2| 0| 0| 2| 2| 0| 5| 1| 6| 2| 0| 1| 1| 3| 1| 1| 0| 1| 3| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |    1  1        1  1                 1     1  1  1           1     1  1   |             
      Pigmentation                         | 1  1     1  1     1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1   |             
      Thrombosis                           |                1                                                         |             
      Alveolar Epithelium, Hyperplasia     |                         2                       1           1  4         |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                           X                              |             
      Inflammation                         |       1  2                                2                       1      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                        2                                 |             
      Inflammation                         |                2                                                         |             
      Nephropathy                          | 1  1     1  1  1  1  1  1  1     1  1     1  1  1  2     1  1  1  1  1  1|             
      Pigmentation                         |                1                          1           1                 1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                                               X                 X   |      3     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       1                  |      1  1.0|
      Basophilic Focus                     | X     X  X  X  X  X  X     X  X     X  X     X  X  X  X  X  X  X  X  X  X|     43     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   | X     X                             X                       X  X  X     X|     14     |
      Hepatodiaphragmatic Nodule           |                X              X                    X  X                  |     12     |
      Inflammation                         | 1     1  1  2  1  1  1     1  1     1  1     1  1  1  1  1  1  1  1  2  1|     39  1.1|
      Mixed Cell Focus                     |       X                       X     X        X           X        X      |      7     |
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                         1                                                |      1  1.0|
      Vacuolization Cytoplasmic            | 1     1        3                       1     2              1            |      9  1.8|
      Bile Duct, Hyperplasia               |          1  1     1  1  1  1     1        1  1           1     1     1  1|     21  1.0|
      Centrilobular, Degeneration          |    1              1  3  2  1                                             |     10  2.2|
      Centrilobular, Hypertrophy           | 2     1  2  1                 1        1     1  1  2     2     1     1   |     24  1.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +  +                                                               |   4        |
      Fat, Necrosis                        | 3     3  3                                                               |      4  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          1                                      1           1            |      8  1.1|
      Cytoplasmic Alteration               |                                                                1         |      1  1.0|
      Inflammation                         |       1     1                                      1     1               |      7  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  1.0|
      Cytoplasmic Alteration               |    1                                                                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                              3                           |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation                         |                                              2                           |      1  2.0|
      Ulcer                                |                                              2                           |      2  1.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |       1                                                                  |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                           1                              |      3  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |          1        1        1  1  1  1  1                       1  1     1|     23  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Valve, Inflammation                  |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       1     1              1        1  1     1  1  1     1     1     1  1|     26  1.0|
      Degeneration, Cystic                 |                         1                                                |      2  1.0|
      Hyperplasia                          |    1              1        1                 1        1        1  1  1  1|     19  1.1|
      Hypertrophy                          |                      1              1     1              1               |      5  1.0|
      Inflammation                         |                                                    1                     |      1  1.0|
      Necrosis                             |                2                                                         |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      5  1.8|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          4                                                               |      2  4.0|
      Hyperplasia                          |                         4                                4               |      3  3.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +|  42        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       2  3  2        1     2        1              2     3        2  2   |     23  1.8|
      Pars Distalis, Hyperplasia           |    3  2     1        4           1  2              2              2  2  3|     23  2.0|
      Pars Intermedia, Hyperplasia         |       1                                                                  |      1  1.0|
      Pars Nervosa, Hyperplasia            |                                                                   1      |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       1     1        1     1  2     1     1  1  1  1  1        1  1  1  1|     34  1.2|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3  3              4                                      1     4      |      6  3.0|
      Inflammation                         |    3  2  1                 2  1        1        1     1        1  3     1|     21  1.3|
      Duct, Cyst                           |             1              4                                             |      2  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                         3                                                |      1  3.0|
      Cyst                                 |                            2                                             |      3  1.3|
      Infiltration Cellular, Histiocyte    |                                                    2                     |      3  2.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                                    3              4      |      4  3.5|
      Cervix, Cyst, Squamous               |                                                                          |      1  3.0|
      Cervix, Hydrometra                   |                   3                                                      |      1  3.0|
      Cervix, Hyperplasia, Squamous        |                                        2                                 |      1  2.0|
      Cervix, Inflammation                 |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                         2           2                          1     2   |      7  1.7|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          3        3  4           2  1                                    |      8  2.6|
      Inflammation, Granulomatous          |                                     1                                    |      2  1.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +        +  +        +  +  +     +     +  +  +     +  +  +  +  +|  28        |
      Mediastinal, Pigmentation            | 1  1  1  2        1           1  1  2     2     1  1  1     1  1  1  1  1|     26  1.2|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |                      2                 1                                 |      5  1.2|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          3                                                               |      1  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                              X                           |      1     |
      Fibrosis                             |          1        1                                                      |      2  1.0|
      Hematopoietic Cell Proliferation     |                                              1  1        1           1   |      7  1.3|
      Infarct                              |                                  4                                       |      1  4.0|
      Pigmentation                         |       1     1  2              1     1     1  2     1  2     1  1  1  1  1|     28  1.2|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3  4  4  2  3  3  4        4  3  2  4  3  3  3  3  3  3  4  3  3  3  3  3|     47  3.3|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                1         |      1  1.0|
      Galactocele                          |                3                             2                           |      6  2.8|
      Hyperplasia                          | 1     1  1        1        1              1     1  1  1  2  1        1   |     20  1.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 8| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 7| 2| 1| 0| 4| 1| 0| 5| 2| 0| 0| 1| 1| 7| 8| 1| 0| 2| 1| 0| 2| 0| 0| 2|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                    3                     |      6  2.8|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                       +                  |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  1                                       |      1  1.0|
      Inflammation                         | 1           1  1  1  2     1     1  1  1              1  1              1|     23  1.0|
      Pigmentation                         | 1     1  1  1  1  1        1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|     42  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                     1        2           1           4  1|      9  1.9|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation                         |                                                                          |      4  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Nephropathy                          | 1     1  1     1  2     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1|     42  1.0|
      Pigmentation                         |          1  1        1                    1        1                     |      9  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                         X                           |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   1      |             
      Basophilic Focus                     | X  X  X  X        X  X     X  X  X     X  X           X  X     X  X  X  X|             
      Clear Cell Focus                     |                               X                                          |             
      Eosinophilic Focus                   |                   X                                                     X|             
      Hematopoietic Cell Proliferation     |                                                       1                  |             
      Hepatodiaphragmatic Nodule           |       X  X     X  X                 X           X                       X|             
      Inflammation                         | 1     1           1        1  1  1        1  1     2  1  1  1     1  2  1|             
      Mixed Cell Focus                     |       X                                                     X           X|             
      Necrosis                             |                                                 1              1         |             
      Vacuolization Cytoplasmic            | 1  1           2                                2     1        1  1      |             
      Bile Duct, Hyperplasia               | 1  1  1  1     1  1     1  1  1        1  1  1     1     1  1  1  1     1|             
      Centrilobular, Degeneration          |             2  2                                      1                  |             
      Centrilobular, Hypertrophy           | 2  2  2           2  1  1  1  2  1  1  2  2  2  1  2     1  2     2  2  2|             

                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                         +     +|             
      Artery, Inflammation                 |                         2                                                |             
      Fat, Necrosis                        |                                                                   3     3|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  1                                1  1   |             
      Cytoplasmic Alteration               |    1                                                                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |       1                                                                  |             
      Metaplasia, Hepatocyte               |                            1                                             |             
      Artery, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               1                                          |             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                 +                        |             

                                            __________________________________________________________________________|             
   Tooth                                   |                               +              +                 +         |             
      Inflammation                         |                                                                4         |             
      Peridontal Tissue, Inflammation      |                               2              2                           |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation                  |                                        2                                 |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1     1     1     1     1  1     1  1  1        1     1  2     1   |             
      Inflammation                         |                                                    1                     |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                 2                        |             
      Angiectasis                          | 1                 1           1  1     1  1  1     1     1  1        2  1|             
      Hyperplasia                          | 1  1              1  1     1     1        1                    1        1|             
      Hypertrophy                          |                                        2           1                     |             
      Necrosis                             |             1                                                  2         |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                                                        |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  2     1              2                 4     2  1        2     1     2|             
      Cyst                                 |                                              1                           |             
      Pars Distalis, Hyperplasia           | 3  3  3           1     3  2     3              2  1        2        2   |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4  2                          1        3           1        1     1      |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
      Inflammation                         |                         1  1     1  1           1        1              1|             
      Duct, Cyst                           |       3                                                                  |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                   1      |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              4                           |             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                             1            |             
      Cervix, Cyst, Squamous               |                                                                          |             
      Cervix, Inflammation                 |       4                                                                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Adenomyosis             |                   2                                                      |             
      Endometrium, Hyperplasia, Cystic     |                                              1                    2      |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2           3        2  3                          3     3            |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +        +  +        +  +  +                 +  +     +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Pigmentation            | 1     1           2        1  2        1  1  1                 2  1     2|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 1                                                                    1   |             
      Hyperplasia, Plasma Cell             |                            4                                   4         |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  1                                       |             
      Hematopoietic Cell Proliferation     |                                                       4           1      |             
      Pigmentation                         | 1     2  2        1  2        2     1  1  1  1  3  2     2  1  2     2  1|             
      Lymphoid Follicle, Atrophy           |                      3                          3              3         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  3  3     3  3  4  4  3  3  3  2  3  4  4  4  3  3  3  3  3  3  2  4|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                            1  1                          1  1           1|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            3                                             |             
      Ulcer                                |                            2                                1            |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        | 3                 4                                                      |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                2         |             
      Necrosis                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 5| 6| 7| 4| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 3| 1| 3| 8| 3| 3| 5| 3| 3| 3|             
                                           | 0| 0| 0| 5| 1| 1| 1| 4| 2| 2| 2| 0| 7| 1| 2| 0| 1| 2| 4| 0| 1| 9| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    300 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |    1  1           1     1        1     1  1  1  1  1  1  1  1  1  1      |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  1  1           1     1  1  1  1     1  1  1     1     1  1        1  1|             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                            1              2        1                     |             
      Mediastinum, Thrombosis              |                                                                          |             
      Serosa, Inflammation                 |                                                                1         |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              1                           |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Atrophy                              |                                                                          |             
      Cataract                             |    3                                                                     |             
      Hemorrhage                           |                                                                          |             
      Cornea, Edema                        |                                                                          |             
      Retina, Degeneration                 |    2                                                                     |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation                         |                   1                                                      |             
      Nephropathy                          | 1  2  2        2  1     1  1  1  1     1  1  1     1  1  1  1  1  1  1   |             
      Pigmentation                         |                1                                                  1      |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                      X                                                   |             
      Transitional Epithelium, Hyperplasia |                      4                                                   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3|            |
                                           | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    300 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                                             |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                           X           X                  |      4     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      1                                                   |      2  1.0|
      Basophilic Focus                     | X  X  X     X     X  X  X     X  X  X  X  X  X     X  X  X  X  X        X|     36     |
      Clear Cell Focus                     |                                                             X            |      2     |
      Eosinophilic Focus                   | X                    X              X     X        X                     |      7     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |          X     X              X     X           X           X        X   |     14     |
      Inflammation                         |       1           1     1  1  1  1  1  1  1  1        1     1  1     2  1|     30  1.1|
      Mixed Cell Focus                     |                   X     X     X     X        X     X                     |      9     |
      Necrosis                             |                1                                                     2   |      4  1.3|
      Vacuolization Cytoplasmic            |                               1                    1                     |      9  1.2|
      Bile Duct, Hyperplasia               |    1  1     1  1  1           1  1  1           1  1     1  1  1     1   |     32  1.0|
      Centrilobular, Degeneration          |          3  1  1                                2                        |      7  1.7|
      Centrilobular, Hypertrophy           | 1  1  1           2  2  2     2  2  2  2  2  2        2  1  2  2  1     2|     38  1.7|

                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   4        |
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Fat, Necrosis                        |             3                                                            |      3  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1                 1                    1  1        1                     |      8  1.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Hyperplasia                          |                                                    3                     |      1  3.0|
      Inflammation                         |    1                                1                                    |      3  1.0|
      Metaplasia, Hepatocyte               |                                                                          |      1  1.0|
      Artery, Inflammation                 |                            1                                             |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          1                                                               |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                 1  1                     |      3  1.0|
      Mineralization                       |       2                                                                  |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3|            |
                                           | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    300 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |                               +                                          |   4        |
      Inflammation                         |                                                                          |      1  4.0|
      Peridontal Tissue, Inflammation      |                               2                                          |      3  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1     1     1  1     1     1  1           1        1  1        1   |     27  1.1|
      Inflammation                         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Angiectasis                          | 1  1        1     1  1  1     1  1  1        1     2        1     1     1|     26  1.1|
      Hyperplasia                          |             1     1  1  1  1  1     1                             1     2|     18  1.1|
      Hypertrophy                          |                                        1                                 |      3  1.3|
      Necrosis                             |                                                                          |      2  1.5|
      Vacuolization Cytoplasmic            |                                                                         1|      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +|  43        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2        1     1     3     2  3  2  2  2  2     2                     |     21  1.9|
      Cyst                                 | 3                                                                    2   |      3  2.0|
      Pars Distalis, Hyperplasia           | 2  2        2           1  4  1     3  2  3     3  2                 1  2|     24  2.2|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1  4     1     1  1  1     1  2  1  1  1  1  1  1  1                 1|     23  1.4|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                   3                       3                              |      3  2.7|
      Inflammation                         |             1     1  1  1     1     1        1     1  1        1  1      |     18  1.0|
      Duct, Cyst                           |                            2                                            1|      3  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3|            |
                                           | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    300 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         4                       1                        |      2  2.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Dilatation                           |                                                       4                  |      1  4.0|
      Hyperplasia                          |                                        2                                 |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|
      Cervix, Cyst, Squamous               |                               2                                          |      1  2.0|
      Cervix, Inflammation                 |                                        4                                 |      2  4.0|
      Endometrium, Adenomyosis             |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                      1        2  2                             1         |      6  1.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2        2  3              2                          3               |     12  2.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +  +  +  +  +        +  +  +  +           +  +        +     +|  28        |
      Mediastinal, Congestion              |       4                                                                  |      1  4.0|
      Mediastinal, Ectasia                 |       2                                                                  |      1  2.0|
      Mediastinal, Pigmentation            | 1     1     1     2  2  2        1  1  1  2           1           1     2|     24  1.4|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                               1                       1        1         |      5  1.0|
      Hyperplasia, Plasma Cell             |       3                    3                                         4   |      5  3.6|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Pigmentation                         |       1           1  2  1  2  2  1  1  1  2  2        1     2     2     1|     32  1.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      3  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              | 3  3  2  4  4  4  4  4  3     4  3  3  3  3  4  4  3  3  4  4  4  3  4  3|     48  3.4|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2                                                                  |      1  2.0|
      Galactocele                          |                                                 4                        |      1  4.0|
      Hyperplasia                          | 1     1           1              3        1                              |     10  1.2|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3|            |
                                           | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    300 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                     3                          3         |      4  3.3|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|
      Necrosis                             |                                                 2                        |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                      2   |      1  2.0|
      Hemorrhage                           |                1                                                         |      1  1.0|
      Inflammation                         |    1  2     1  1     1  1  1  1  1     1        1        1     1  1  2  1|     31  1.1|
      Necrosis                             |       2                                                              2   |      2  2.0|
      Pigmentation                         | 1  1  2     1     1  1  1     1  1  1  1  1  1     1  1     1  1  1     1|     35  1.0|
      Thrombosis                           |                                                          3               |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                      3     1        1              3        3     1      |      9  1.8|
      Mediastinum, Thrombosis              |                                                          4               |      1  4.0|
      Serosa, Inflammation                 |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1              1           2                       1                  |      4  1.3|
      Nasolacrimal Duct, Inflammation      |                            3                                             |      1  3.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                               +        +  +                              |   4        |
      Atrophy                              |                                           3                              |      1  3.0|
      Cataract                             |                               3        3                                 |      3  3.0|
      Hemorrhage                           |                               2                                          |      1  2.0|
      Cornea, Edema                        |                                           3                              |      1  3.0|
      Retina, Degeneration                 |                               3        4                                 |      3  3.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3|            |
                                           | 3| 2| 1| 9| 0| 7| 2| 2| 0| 4| 1| 1| 1| 2| 1| 2| 9| 1| 0| 1| 1| 2| 1| 7| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    300 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydronephrosis                       |                                                          2               |      1  2.0|
      Inflammation                         |                      1                                                   |      2  1.0|
      Nephropathy                          | 1  1  2  2  1  1  1  2  2     1  1  1  1  1  1  1  1  1  1  1  1  1     1|     42  1.2|
      Pigmentation                         | 1              2              1           1  1  2                    1   |      9  1.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Gross Observation           |                                                                          |      1     |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|             
                             DAY ON TEST   | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|             
                                           | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X        X  X  X  X  X  X        X  X  X              X  X  X  X   |             
      Clear Cell Focus                     |                      X     X           X                                 |             
      Degeneration, Cystic                 | 1           1                          1                             1   |             
      Eosinophilic Focus                   |                         X  X                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X        X                                                      |             
      Inflammation                         |       1        1  1  1  1  1     1     1                          1      |             
      Mixed Cell Focus                     |       X           X  X        X                                          |             
      Necrosis                             |    2                                                     1               |             
      Pigmentation                         |                                                    2                     |             
      Vacuolization Cytoplasmic            |       1           1              1     1                    1            |             
      Bile Duct, Hyperplasia               | 2  1  2  3  3     1  1  1  1  1  1  3  1  2  2  1  2  2  2  2  1  1  2   |             
      Centrilobular, Degeneration          | 2        3  1                                1  1  2  3  2           1   |             
      Centrilobular, Necrosis              |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                     +        +                       +   |             
      Necrosis                             |                                              2                           |             
      Fat, Inflammation                    |                                                                          |             
      Fat, Necrosis                        |                                     3                                3   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      4        1     1           1  1        1        1   |             
      Cytoplasmic Alteration               |                                                                      1   |             
      Hyperplasia                          |                   1                                               1      |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             1            |             
      Cytoplasmic Alteration               |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       2                  |             
      Hyperplasia                          |                                                       3              3   |             
      Inflammation                         |                                                                      3   |             
      Ulcer                                |                                                       3              4   |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|             
                             DAY ON TEST   | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|             
                                           | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                       1                  |             
      Hyperplasia                          |       2                                                                  |             
      Ulcer                                |    1                                                                     |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         2                                                |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2  1     1  2  1  1  1  1  1     2  1  1  2           1  1  1      |             
      Inflammation                         |             1                                                            |             
      Thrombosis                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1           1                                 |             
      Degeneration, Cystic                 |                                                                         1|             
      Hyperplasia                          | 1           1              1           2  1  2                          1|             
      Hypertrophy                          |                                  1                    3                  |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 2                       2              2              3              4  3|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                    1                 2        1                  |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              1                           |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   3                          4        4     3            |             
      Cyst                                 |                                     1                                    |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                         3  3  1        1              2           3      |             
      Pars Distalis, Pseudocyst            |          2                          2           2                        |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Pseudocyst          |             2                                                            |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      C-Cell, Hyperplasia                  | 2     1     1              1           1  1  1        2     1  1     3   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|             
                             DAY ON TEST   | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|             
                                           | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                1                                                         |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1     1  2  1     1  2  1     1  2  1  2  2  2  1  2  2  2  2  2  3  2  1|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 3        1        3  1     1     3  1  3  3  2  1        1           1  2|             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             
      Inflammation                         |                                                                         1|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         4        4                                      3|             
      Hyperplasia                          |                                                                          |             
      Artery, Inflammation                 |                         2                                                |             
      Interstitial Cell, Hyperplasia       | 1  1     1     1        1        1  1  1  1     1  1  1        1     1  1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2  3                                2     2  4              4     3  2|             
      Myelofibrosis                        |                                                    4                     |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                   +     +  +  +  +        +   |             
      Mediastinal, Necrosis                |                                                    4                     |             
      Mediastinal, Pigmentation            |                                              1              1        2   |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Necrosis                      |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                           4  4                           |             
      Necrosis                             |                                                    4                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2                                          |             
      Necrosis                             |                                                    4                     |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                        X                                 |             
      Fibrosis                             |                                                                   4      |             
      Hematopoietic Cell Proliferation     |                                                 2              1         |             
      Hyperplasia, Stromal                 |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                         2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  2  4  4  4  2  4  4     4  2  4  4  3  3     4  2     3  3  4  3  4  4|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|             
                             DAY ON TEST   | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|             
                                           | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                                                        |             
      Hyperplasia                          |                                  1           2                           |             
      Inflammation                         | 4                                                                        |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Ulcer                                | 2                                                                        |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                    3                     |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    3                                2                                    |             
      Necrosis                             |                                                                      2   |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
      Hemorrhage                           |    1                                                                     |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                X         |             
      Hemorrhage                           |                                     2                    1               |             
      Inflammation, Granulomatous          |                                                                2         |             
      Inflammation                         |    1     1        1           1     1     1     1        1               |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |          1                                                               |             
      Thrombosis                           |          1                                                               |             
      Alveolar Epithelium, Hyperplasia     |                   1     2                                                |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation                         |                                                       1              2   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                         +|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |          4                                                               |             
      Nephropathy                          | 1     2  1  2  1  2  2  1  1  1  3     2  1  2  1     2  1  2  2  1  1   |             
      Pigmentation                         |    1     2                                   1     1  1  1  1        1  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 7| 6| 6| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 6| 3|             
                             DAY ON TEST   | 8| 6| 3| 3| 8| 1| 2| 2| 2| 3| 3| 1| 4| 3| 2| 3| 9| 1| 1| 2| 3| 4| 1| 4| 6|             
                                           | 2| 8| 0| 3| 2| 2| 9| 9| 9| 0| 0| 7| 0| 0| 9| 0| 7| 2| 8| 9| 0| 2| 8| 8| 1|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation                 |                         2                                                |             
      Renal Tubule, Degeneration           |                                                                         1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3|            |
                             DAY ON TEST   | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1|            |
                                           | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            X                                             |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                       X              X   |      3     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |             1                                                            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X  X     X  X        X     X     X  X  X  X  X  X     X        X   |     30     |
      Clear Cell Focus                     |          X                             X     X                           |      6     |
      Degeneration, Cystic                 |    1                                                                     |      5  1.0|
      Eosinophilic Focus                   |    X                       X                          X     X            |      6     |
      Hematopoietic Cell Proliferation     |                                                 1                        |      1  1.0|
      Hepatodiaphragmatic Nodule           | X                                         X  X              X        X   |      7     |
      Inflammation                         |       1  1     1  1        1     1     1        1     1                  |     18  1.0|
      Mixed Cell Focus                     |                   X              X                          X            |      7     |
      Necrosis                             |                                           1              4               |      4  2.0|
      Pigmentation                         |                1                                                         |      2  1.5|
      Vacuolization Cytoplasmic            |          1     1                          2           1                  |      9  1.1|
      Bile Duct, Hyperplasia               | 3  1  1  2  2  2  2  3     2  2  2  2  2  2  1  2  1  1     1  3  3  1  1|     46  1.7|
      Centrilobular, Degeneration          | 2           2        2        2     3              2           2  3  2   |     18  2.0|
      Centrilobular, Necrosis              |                         4                                                |      1  4.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                +  +                    +|   7        |
      Necrosis                             |                                                                          |      1  2.0|
      Fat, Inflammation                    |                3                                                         |      1  3.0|
      Fat, Necrosis                        |                                                 1                        |      3  2.3|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             1  1  2                          1        1        2  1      |     14  1.4|
      Cytoplasmic Alteration               |                1                                                         |      2  1.0|
      Hyperplasia                          |                                                                4         |      3  2.0|
      Inflammation                         |    1                                                                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  1.0|
      Cytoplasmic Alteration               |                                                 1                        |      1  1.0|
      Duct, Hyperplasia                    |                1                                                         |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3|            |
                             DAY ON TEST   | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1|            |
                                           | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                1         |      2  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Ulcer                                | 1                                                                        |      2  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                                                   |   1        |
      Peridontal Tissue, Inflammation      |                      4                                                   |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  2  2  1  1  1  1     2  1  2     1  1  2  2  2  2  2  1  1  1  1   |     39  1.4|
      Inflammation                         |                                                                          |      1  1.0|
      Thrombosis                           |                                                                3         |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.0|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Hyperplasia                          |       1                                1              1              1   |     11  1.2|
      Hypertrophy                          | 1                                                                        |      3  1.7|
      Necrosis                             |                         1                                   1            |      2  1.0|
      Vacuolization Cytoplasmic            |          1           2                                                   |      8  2.4|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2           4  4  2        1              2     3     4        1      |     14  2.1|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|  46        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1     2           1                                                      |      7  2.6|
      Cyst                                 |                                              1                           |      2  1.0|
      Hemorrhage                           |             1                                                            |      1  1.0|
      Pars Distalis, Hyperplasia           |       4  2  1     2           1              1  2           1  3         |     15  2.0|
      Pars Distalis, Pseudocyst            |             2              2  2                                          |      6  2.0|
      Pars Intermedia, Cyst                |                            1                                             |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3|            |
                             DAY ON TEST   | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1|            |
                                           | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Pseudocyst          |             1                                                           2|      3  1.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      2                                                   |      1  2.0|
      C-Cell, Hyperplasia                  | 4  1              1              1     1  1           1              1   |     19  1.4|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               1                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 2  2  2  1  2  1  2  3  1  1  2  2  1  2  1  2     2  2  1  1  2  2  2  1|     46  1.7|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 1     1  1     1  2        1     1  1              2  1     1  2  1      |     27  1.6|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          4                                                     3         |      5  3.6|
      Hyperplasia                          |                               3                                          |      1  3.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       | 1           1        1  1           2  1  1     1  1  2  1        1  1   |     28  1.1|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2                 4     2  2           2  2  4        2  2            |     18  2.6|
      Myelofibrosis                        |             2        2                                            1      |      4  2.3|
      Necrosis                             |                         4                                                |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +        +              +              +              +  +  +|  15        |
      Mediastinal, Necrosis                |                                                                          |      1  4.0|
      Mediastinal, Pigmentation            |             2                                                            |      4  1.5|
      Renal, Hyperplasia, Plasma Cell      |                      3                                                   |      1  3.0|
      Renal, Necrosis                      |                      4                                                   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                   2           1                             1            |      3  1.3|
      Hyperplasia, Plasma Cell             |                      4                 3                                 |      4  3.8|
      Necrosis                             |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3|            |
                             DAY ON TEST   | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1|            |
                                           | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Fibrosis                             |                                              1                           |      2  2.5|
      Hematopoietic Cell Proliferation     |                                           2     2                        |      4  1.8|
      Hyperplasia, Stromal                 |                         4                                                |      1  4.0|
      Necrosis                             |             4                                                            |      1  4.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Lymphoid Follicle, Atrophy           |                         4                                4               |      2  4.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|  46        |
      Atrophy                              |    3  3  3  4  3  4  4  4  3  3  3  4  4  1  3     4  3  4  4  4  4  3   |     44  3.4|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  1.5|
      Inflammation                         |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7| 3|            |
                             DAY ON TEST   | 8| 2| 2| 2| 1| 3| 2| 2| 5| 2| 3| 3| 6| 3| 4| 3| 1| 8| 2| 2| 2| 7| 1| 3| 1|            |
                                           | 2| 9| 9| 9| 3| 0| 9| 3| 4| 9| 0| 0| 9| 0| 0| 0| 1| 7| 9| 8| 9| 4| 4| 0| 3|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Inflammation                         |                      2        1                             1            |     11  1.1|
      Necrosis                             |                      3                                                   |      1  3.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    1  4     4     1           3                    1                 2   |      9  2.1|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    X     X                 X                    X           X            |      5     |
      Inflammation                         | 1  2     2        1  3     1     1  1           1           2            |     12  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy                          | 1  1  1  2  1  1  2  1     2  1  1  1  2  1  2     1  1     1  2  1  2   |     42  1.4|
      Pigmentation                         |                      1                    1                       2  1   |     13  1.2|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Renal Tubule, Degeneration           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3|             
                                           | 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X                           |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                    X        X                                 |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X     X  X  X        X  X     X     X     X     X     X  X     X|             
      Clear Cell Focus                     |          X                    X        X     X                    X     X|             
      Degeneration, Cystic                 |             1                                      1        1            |             
      Eosinophilic Focus                   |                   X                    X                          X      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                    X                    X            |             
      Inflammation                         |    1              1           1  1     1     1     1              1  1  1|             
      Mixed Cell Focus                     |       X  X                       X                 X     X        X     X|             
      Necrosis                             |                1                                                         |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |                2                       1                                 |             
      Bile Duct, Hyperplasia               | 3  2  1  1  2  1  1  2  3  3  2  1  2     2  1  2  1  1  1  2  1  1     1|             
      Centrilobular, Degeneration          | 2           2              1        4     1     1     3     2            |             
      Centrilobular, Hypertrophy           |                                              1                           |             
      Centrilobular, Necrosis              |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                            +                 +           +        +     +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                              2                           |             
      Fat, Inflammation                    |                                                                   2      |             
      Fat, Necrosis                        |                            3                             3              3|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                    1  1     1                    1  2  1  2   |             
      Cytoplasmic Alteration               |                                              1                           |             
      Hyperplasia                          |                   1                                                      |             
      Inflammation                         |                                                                          |             
      Duct, Hyperplasia                    |                                              1                           |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3|             
                                           | 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |             2                                                            |             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                             1            |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  2  1  2  1  1  1     1  2  1  1  1  1  2  2  1  2  2     1  2  1  1|             
      Thrombosis                           |                         3                             3     3            |             
      Epicardium, Hyperplasia              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |    1  2                 1                 2     1        1               |             
      Hypertrophy                          |                      1  1                                                |             
      Vacuolization Cytoplasmic            |             1  1                                   1              1      |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2  1  1              4              1  1            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                     4           2     3|             
      Cyst                                 | 2           1  1                                            1  1     1   |             
      Pars Distalis, Hyperplasia           |                1  1     2  2     1                    3     2        4  4|             
      Pars Intermedia, Hyperplasia         |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2  1  3     1  1  1     1           1  1  1  1  1     1  1     1      |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                                  |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Mesothelium, Hyperplasia             |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  2  1  2  1  1  2     2  2  2  2     2  1  1  1     2  1  1  1     2|             
      Duct, Cyst                           |                                                                         2|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3|             
                                           | 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             1                                                            |             
      Inflammation                         | 2  3  3  3     1  1  1  1  2  3  2  3  1  3           4  1  4     3  1  2|             
      Dorsal, Cyst, Mucous                 |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4              4                             3                  |             
      Cyst                                 |                                           4                              |             
      Interstitial Cell, Hyperplasia       | 1  1  3  1     1  1  1     1        1     1  1  1  1  1     1  1  1  1  1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2     2  3  3  2  2        3           2        2  3  3     4   |             
      Myelofibrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +           +              +                                +        +   |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                      4   |             
      Mediastinal, Atrophy                 |                            2                                             |             
      Mediastinal, Ectasia                 |                                                             1            |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Necrosis                 | 4                                                                        |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               2                                          |             
      Hyperplasia, Plasma Cell             |                                                                      3   |             
      Necrosis                             | 4                                                                        |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          1                                                               |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Necrosis                             | 4                                                                        |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |                                           2                              |             
      Hematopoietic Cell Proliferation     |                                                             3        4   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Infarct                              |                         4                                                |             
      Pigmentation                         |    1                                                                     |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  2  4  4  3  4  4  3  3  4  3  4  3  3  3  3  4  4  4  4  3  3  4  4|             
      Artery, Inflammation                 |                3                                                         |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  2                 1  1                                                |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 1| 9| 2| 2| 5| 3| 3| 0| 2| 3| 2| 3| 0| 3| 2| 3| 3| 3| 6| 2| 0| 3| 3| 0| 3|             
                                           | 7| 6| 9| 9| 9| 0| 0| 8| 9| 0| 9| 0| 1| 0| 9| 0| 0| 0| 9| 9| 9| 0| 0| 3| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 PPM                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                                                      4   |             
      Ulcer                                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |             3                                                            |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1                                                                        |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1        1     1              1     1     1  1     1  1     1  1|             
      Necrosis                             | 3                                                                        |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       2  1                                                              1|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      X           X     X                    X            |             
      Inflammation                         |                      1     1  1  2     1                    1            |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                                                                     |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Inflammation                         |                               2                                          |             
      Nephropathy                          | 1  2  3  2  1  1  1  1  1  1  2  1  1  1  1  2  1  2  1  1  1  1  2  2  1|             
      Pigmentation                         |                      1                                                   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2|            |
                                           | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                                                     X  X            |      4     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X                          X                 X            |      6     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                               X                                          |      1     |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X     X  X  X     X  X                    X  X  X  X  X  X  X         |     29     |
      Clear Cell Focus                     |    X           X                                      X        X        X|     11     |
      Degeneration, Cystic                 |                         1                                                |      4  1.0|
      Eosinophilic Focus                   |    X           X     X                    X                    X         |      8     |
      Hematopoietic Cell Proliferation     |       1                                                                  |      1  1.0|
      Hemorrhage                           |                         2                                                |      1  2.0|
      Hepatodiaphragmatic Nodule           |    X                                         X                           |      5     |
      Inflammation                         | 1  1        1  2     1           1     1  1  1  1  1  1  1  2  1     1  1|     27  1.1|
      Mixed Cell Focus                     |    X     X  X  X                          X  X              X  X     X  X|     17     |
      Necrosis                             |                                                                          |      1  1.0|
      Thrombosis                           |                         4                                                |      1  4.0|
      Vacuolization Cytoplasmic            |                                                 1  1                     |      4  1.3|
      Bile Duct, Hyperplasia               | 1  1  1  2  1  1  3  1  1  2  2  1  1  1  1     2  2  2  2  1  1  1  2  2|     47  1.5|
      Centrilobular, Degeneration          |       2           3        1  2     4           1                 2      |     15  2.1|
      Centrilobular, Hypertrophy           |                                                                          |      1  1.0|
      Centrilobular, Necrosis              |                         3                                                |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                    +  +     +           +           +           +|  12        |
      Hemorrhage                           |                            4                                             |      1  4.0|
      Inflammation                         |                                                                          |      1  2.0|
      Fat, Inflammation                    |                                                                          |      1  2.0|
      Fat, Necrosis                        |                               3                 3           3           3|      7  3.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2     1  1                                2              1  2   |     14  1.4|
      Cytoplasmic Alteration               |                                                                   1      |      2  1.0|
      Hyperplasia                          |                2                                                         |      2  1.5|
      Inflammation                         |    1        1                                         1        1         |      4  1.0|
      Duct, Hyperplasia                    |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2|            |
                                           | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                  3                                       |      1  3.0|
      Hyperplasia                          |                                  2              2                        |      2  2.0|
      Inflammation                         |                                                 1                        |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                               1                                          |      1  1.0|
      Ulcer                                |                                              1                           |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  1  2  2  1  2  1     1  1  1  1  1  1  2  1  1  1  1  2  2  1  2  2|     46  1.4|
      Thrombosis                           |                   2           4                                          |      5  3.0|
      Epicardium, Hyperplasia              |                         3                                                |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    1                     |      1  1.0|
      Hematopoietic Cell Proliferation     |       1                                                                  |      1  1.0|
      Hyperplasia                          | 1        2                       1              2        1           2  1|     13  1.4|
      Hypertrophy                          | 1              1                    1                       2           1|      7  1.1|
      Vacuolization Cytoplasmic            |             1                                      1                     |      6  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      1                       1        3  1               |     10  1.6|
      Infiltration Cellular, Lymphocyte    |       2                                                                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                      4   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                                    1                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 2              2                                                         |      6  2.5|
      Cyst                                 |    1                             1                                       |      8  1.1|
      Pars Distalis, Hyperplasia           |          2        2           2     1  1                 1     1        2|     17  1.9|
      Pars Intermedia, Hyperplasia         |                      1                                                   |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 4  1     1  1  1              1           1  1  1  1  1     1  2     1  2|     30  1.3|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2|            |
                                           | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                     +                                    |   1        |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  2                                       |      1  2.0|
      Mesothelium, Hyperplasia             |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 2  1  2  2  1  2  2  1  1  2  2  1  2  2     2  2  2  1  2  1  1  2  1  2|     45  1.6|
      Duct, Cyst                           |          1                                                              1|      3  1.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  1.0|
      Inflammation                         | 1           1  3  2  2  1  1  1  1  3  1  3     3  4  2        3     1  1|     38  2.1|
      Dorsal, Cyst, Mucous                 |                   3                                                      |      1  3.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       4     4     4                                                  4   |      7  3.9|
      Cyst                                 |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       | 2  1     1  1        1  2     1  4  2  1        1  1  1  1  1  1     1  1|     37  1.2|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       3  2                 2        2        2              1            |     18  2.4|
      Myelofibrosis                        |                   3                                2                     |      2  2.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +        +     +     +                                   +      |  11        |
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  4.0|
      Mediastinal, Atrophy                 |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |       4                                                                  |      1  4.0|
      Pancreatic, Necrosis                 |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |    2     2  1        1                                                   |      5  1.6|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  1.0|
      Hyperplasia, Reticulum Cell          |                                     2  1                                 |      2  1.5|
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2|            |
                                           | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Accessory Spleen                     |                                              X                           |      1     |
      Fibrosis                             |             1                                                        1  2|      4  1.5|
      Hematopoietic Cell Proliferation     |       3                 2           2                                    |      5  2.8|
      Hyperplasia, Lymphoid                |                                                 4                        |      1  4.0|
      Hyperplasia, Reticulum Cell          |                                                             4            |      1  4.0|
      Infarct                              |                                                                          |      1  4.0|
      Pigmentation                         |                                                    2                     |      2  1.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |    3  4  3  4  4        4  4  4  2     3  4  3  3  4  3  3  4  3     4  4|     45  3.5|
      Artery, Inflammation                 |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           1     1  1  1                  |      8  1.1|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |          X                                                               |      1     |
      Hyperkeratosis                       |                                                                      2   |      1  2.0|
      Hyperplasia                          |                                                                      2   |      1  2.0|
      Inflammation                         |                                                                          |      1  4.0|
      Ulcer                                |                                                                      2   |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                             +                                    |   2        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 1              1     1                    1              1               |     16  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                   1                                                      |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    1                                         3        2              1   |      7  1.6|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                      X                                X                  |      6     |
      Inflammation                         |                      1                                1           1      |      9  1.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 6| 5| 5| 3| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 3| 3| 2| 2| 2| 1| 8| 6| 1| 9| 8| 6| 2| 1| 8| 2| 3| 2| 3| 3| 2| 2|            |
                                           | 9| 9| 5| 0| 0| 9| 3| 9| 0| 5| 3| 2| 2| 6| 3| 9| 8| 7| 9| 0| 9| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 PPM                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                        +                                 |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                               2                                          |      1  2.0|
      Inflammation                         |                                        1                                 |      2  1.5|
      Nephropathy                          | 1  2     1  3  1  3  2  1  1  2  1  1  1  1  2  1  3  2  1  1  2     1  2|     48  1.5|
      Pigmentation                         |       2           1           1                                          |      4  1.3|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|             
                                           | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1                                      1                  |             
      Parasite Metazoan                    |       X                          X        X              X               |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                                               |             
      Basophilic Focus                     | X     X  X  X     X     X     X     X     X  X  X     X  X        X  X  X|             
      Clear Cell Focus                     |                                                 X                       X|             
      Degeneration, Cystic                 |                                     1        1                       1   |             
      Eosinophilic Focus                   |       X                                   X  X                       X   |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X        X           X                                X  X      |             
      Inflammation                         |       1  1  1     1  1  1     2  2              1     1  1           1  1|             
      Mixed Cell Focus                     |                                           X  X        X                 X|             
      Necrosis                             |                                                                1         |             
      Thrombosis                           |    2                                                                     |             
      Vacuolization Cytoplasmic            |          1                                                        2      |             
      Bile Duct, Hyperplasia               |    4     1  2  3  1  1  1  1  1  2  2     2  1  2     1  1  1  3  1  1  1|             
      Centrilobular, Degeneration          |    3           3           2                       3        2  1         |             
      Centrilobular, Hypertrophy           |                                  1              1                       1|             
      Centrilobular, Necrosis              |                                        3                                 |             

                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +     +     +     +           +         |             
      Hemorrhage                           |                                                    4                     |             
      Inflammation                         |                                              2                           |             
      Fat, Necrosis                        |                      2           3     2                       3         |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1  1  1        1     2              1        1        2        1|             
      Inflammation                         |             1     1                       1                          1   |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation                 |                                           2                              |             
      Duct, Cyst                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|             
                                           | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          2               |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    2                     |             
      Hyperplasia                          |                                                    1                     |             
      Ulcer                                |                1                                                         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                            1                       1                     |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                1     1                                                   |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Inflammation                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  2  1  1  2  1  1     1  2  2     2  1  1  1  1  2  1     2  1  3|             
      Thrombosis                           |                                                                3  4     2|             
      Artery, Inflammation                 |                                                          2               |             
      Endocardium, Degeneration            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         1                                               1|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |    2  1                 1                                      2        1|             
      Hypertrophy                          |                   1                             1                        |             
      Vacuolization Cytoplasmic            | 2                                                  3                     |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 1  1           1              4     2                          2  2     2|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                               2              3   |             
      Cyst                                 | 1                                   1                             1      |             
      Hemorrhage                           |                      4                                                   |             
      Pars Distalis, Hyperplasia           |       4     2     3     1  2     3        2           3  1        2      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2  1  1  2  2  2  1              4        1     1           1  1  1  1|             
      Follicular Cell, Hyperplasia         |             2                                                           1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|             
                                           | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 1                        |             
      Mesothelium, Hyperplasia             |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             4                                            3        4      |             
      Inflammation                         | 2  2  1  2  2  1  1  1  1  2  1  2  2     2  2  1  2  2  1  2  2  2  2  2|             
      Duct, Cyst                           |                3                                                  4      |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1     4        2  3     1  1  3        1        2  3     2  3  1  3   |             
      Dorsal, Cyst, Mucous                 |                                  3                                       |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          4                                                               |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    4           4         |             
      Interstitial Cell, Hyperplasia       | 1  2  1  2  2        1  2  1  1        1     1  1  1     2  2        1   |             
      Mesothelium, Hyperplasia             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         3     3  2              3        2  2     3     2|             
      Inflammation, Granulomatous          |       1                                                                  |             
      Myelofibrosis                        |                                                                          |             
      Necrosis                             |                                        4                                 |             

                                            __________________________________________________________________________|             
   Lymph Node                              | +                          +     +  +              +        +            |             
      Mediastinal, Pigmentation            | 1                                1                          3            |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   1           2                                      1   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 1              1         |             
      Hematopoietic Cell Proliferation     | 2                                                        1               |             
      Hyperplasia, Reticulum Cell          |                               4                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lipocyte      |                               2                                          |             
      Pigmentation                         |                      2                                                   |             
      Lymphoid Follicle, Atrophy           |                                                                   3      |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              | 4  4  3     3  3  3     3  4  3  3  3     3  3  4  4  4  3  4  4  4  3   |             
      Epithelial Cell, Hyperplasia         |                      2                                                   |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                                          |             
      Hyperplasia                          |          1     1                                      2     1        1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|             
                                           | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                       2                  |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                   3      |             
      Inflammation                         |                                                                   2      |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                1           2                                             |             
      Necrosis                             |    1           2                          2                              |             
      Thrombosis                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Foreign Body                         |                                              X                           |             
      Hemorrhage                           |                            1                                             |             
      Inflammation                         |       1                       1  1        1  1        1  1           1   |             
      Thrombosis                           |                                                                1         |             
      Alveolar Epithelium, Hyperplasia     |                                              1                           |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         X                                                |             
      Inflammation                         |                         2        2           1  1                        |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         2|             
      Retina, Degeneration                 |                                                                         3|             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |    2                                                                     |             
      Necrosis                             |                                                                4         |             
      Nephropathy                          | 1  1  1  2  1  2  2  1  1  1  1  2  2     1  2  1  1  1  1  2     1  1  2|             
      Pigmentation                         |    1                       1        1        1     1                     |             
      Thrombosis                           |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Urethra                                 |          +                                                               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 4| 7| 7| 7| 5| 7| 5| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 3| 1| 2| 0| 9| 1| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 9| 2|             
                                           | 7| 3| 0| 9| 0| 5| 9| 8| 1| 4| 9| 9| 0| 0| 0| 0| 9| 5| 0| 3| 1| 1| 5| 1| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |          4                                                               |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          3                                                     1         |             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0|            |
                                           | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                             X            |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      2  1.0|
      Parasite Metazoan                    |                                              X     X  X     X            |      8     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                             2            |      1  2.0|
      Ulcer                                | 2                                                                        |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                       2                  |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |    X                 X     X  X     X     X  X     X     X     X         |     26     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 |                   1                                                      |      4  1.0|
      Eosinophilic Focus                   |                      X                       X                           |      6     |
      Fibrosis                             |                1                                                         |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hemorrhage                           |                   1                                                      |      1  1.0|
      Hepatodiaphragmatic Nodule           |                      X           X  X     X                       X      |     10     |
      Inflammation                         |             1        1     1        1              2           1         |     19  1.2|
      Mixed Cell Focus                     |    X                                X        X                          X|      8     |
      Necrosis                             |                                           1                 1            |      3  1.0|
      Thrombosis                           |                                                                   2      |      2  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               | 3  1  2  3  1  3  2  1  2  2  1  2  1  2  2  2  3  2  3  1  1     1     3|     44  1.8|
      Centrilobular, Degeneration          | 1     1        4  2     2  1  1  2        1     3     2           1  2  4|     20  2.1|
      Centrilobular, Hypertrophy           |                                                                          |      3  1.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |             +        +     +                       +              +  +   |  12        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  2.0|
      Fat, Necrosis                        |             2                                      3              3  3   |      8  2.6|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                             +            |   1        |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    1                 2                    1                       1      |     13  1.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0|            |
                                           | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      4  1.0|
      Necrosis                             |                                                             2            |      1  2.0|
      Thrombosis                           |                1                                                         |      1  1.0|
      Artery, Inflammation                 |                                                          3               |      2  2.5|
      Duct, Cyst                           |                               1                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Ulcer                                |                         2                                               1|      3  1.3|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                           1                             1|      4  1.0|
      Mineralization                       | 1                                                                        |      1  1.0|
      Ulcer                                | 3              1                                                         |      4  1.5|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   1        |
      Gingiva, Inflammation                |                                                 2                        |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2  2  1  2  2  1  1     1  1  1  2  2  2  2  1  1  1  2  2  1  1      |     43  1.4|
      Thrombosis                           |                2                                                        4|      5  3.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Endocardium, Degeneration            |                            1                                             |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  1.0|
      Atrophy                              |                                                                   2      |      1  2.0|
      Hyperplasia                          |       1                    1           1                                 |      8  1.3|
      Hypertrophy                          |                1                                                         |      3  1.0|
      Vacuolization Cytoplasmic            |       2           1                                                      |      4  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                 4                        |      1  4.0|
      Hyperplasia                          |       3        2     1  4        3              4                       1|     15  2.2|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0|            |
                                           | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |             1                    2                                      4|      6  2.3|
      Cyst                                 |          1           1  1           1              1  1  1               |     10  1.0|
      Hemorrhage                           |                                              2                           |      2  3.0|
      Pars Distalis, Hyperplasia           |    2  4     1  2  2     1              2           2     4           1  2|     21  2.2|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 4  1  1     1     1  1     2        2     1  1     1  1                  |     26  1.5|
      Follicular Cell, Hyperplasia         |       2                                                                  |      3  1.7|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|
      Mesothelium, Hyperplasia             |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      3                                                   |      4  3.5|
      Inflammation                         | 2  2  1  1  2  2  2  1  2  2  2  1  2  1  1  2  1  2  2  1  1  1  2     2|     48  1.6|
      Duct, Cyst                           |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 2  1     1  2  1  1  1  2     2  2  1        2           3  1  3  2     1|     31  1.9|
      Dorsal, Cyst, Mucous                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2                                                                        |      3  3.3|
      Interstitial Cell, Hyperplasia       | 1           1     1  1        1     1              1  1  1     1  1  1   |     28  1.2|
      Mesothelium, Hyperplasia             |          2                                                               |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3              2  3     4                 3  2  2  2                  |     16  2.6|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Myelofibrosis                        |                                  3                                       |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +     +           +                          +           +  +   |  14        |
      Mediastinal, Pigmentation            |                            4                                             |      4  2.3|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                                          |      3  1.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0|            |
                                           | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                               2              1                           |      4  1.3|
      Hematopoietic Cell Proliferation     |                            3                                             |      3  2.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  4.0|
      Infarct                              |                                                                      2   |      1  2.0|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  2.0|
      Pigmentation                         |                                                                2         |      2  2.0|
      Lymphoid Follicle, Atrophy           |                                                          2     2         |      3  2.3|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy                              |    3        4     4  4  4  3  4     3  4  3  4  4  4  4  4  4  2  4     4|     40  3.6|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          | 1                             2              1                          1|      9  1.2|
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis                              |                                                                         2|      1  2.0|
      Hemorrhage                           | 3                                         2                              |      4  2.0|
      Necrosis                             |                2                                                         |      4  1.8|
      Thrombosis                           |                1                                                         |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                             1            |      1  1.0|
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           |                                           1              2               |      3  1.3|
      Inflammation                         |                   1  1     2  1     1                             2      |     14  1.1|
      Thrombosis                           |                1                                                         |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 4| 6| 4| 7|            |
                             DAY ON TEST   | 6| 3| 2| 3| 3| 1| 4| 2| 5| 3| 8| 0| 3| 7| 0| 3| 0| 2| 6| 4| 7| 8| 0| 4| 0|            |
                                           | 2| 0| 9| 0| 0| 2| 6| 9| 3| 7| 2| 8| 0| 5| 8| 0| 1| 9| 3| 9| 6| 2| 2| 4| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |       4                                                                  |      2  2.5|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                           X                 X            |      3     |
      Inflammation                         |                                           2                 1            |      6  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                           2                              |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                2                          1                              |      3  1.7|
      Necrosis                             |                                                             3            |      2  3.5|
      Nephropathy                          | 2  2  2  2  1  1  1  1  1     2  1  2  1  1  2  1  1                    1|     41  1.4|
      Pigmentation                         | 1                 2     1  2  1  1     1        2     2           1      |     15  1.3|
      Thrombosis                           |                4                                                         |      1  4.0|
      Pelvis, Inflammation                 |                                                                   2      |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      2  2.0|
      Transitional Epithelium, Hyperplasia |                            1                 1                           |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9|             
                                           | 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                 X                                                |             
      Ulcer                                |                                     1                                    |             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     2                                    |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X     X  X  X  X  X  X  X        X     X                 X     X|             
      Clear Cell Focus                     | X  X                                                                     |             
      Degeneration, Cystic                 | 1                                                     1                  |             
      Eosinophilic Focus                   | X  X              X     X                 X                    X         |             
      Fibrosis                             |                1                                                         |             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Hemorrhage                           |                                                                      2   |             
      Hepatodiaphragmatic Nodule           |                X                                                         |             
      Inflammation                         | 1  1           1  1     1  1  1                 1                 1     1|             
      Mixed Cell Focus                     | X     X                    X                    X              X  X      |             
      Necrosis                             |          1                                                  3        2   |             
      Vacuolization Cytoplasmic            | 2  1                                                                     |             
      Bile Duct, Hyperplasia               | 2  1  2  2  2  2  2  1  2  1  1  2  3  3     3  1  3  3  3  2  1  2  3  1|             
      Centrilobular, Degeneration          |          2  1        2              2  2     2     2  2  2  4        4   |             
      Centrilobular, Hypertrophy           |    1  2           2     1  2                    2              1  1      |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +     +        +              +                       +     +  +   |             
      Fat, Inflammation                    |                                     1                                    |             
      Fat, Necrosis                        |       3              3                                      2     3      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                    1     2     1  1                                    |             
      Cytoplasmic Alteration               |                                                                          |             
      Hyperplasia                          |                            2                                             |             
      Inflammation                         |                         1                                                |             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                     3                                4   |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                     1                                2   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9|             
                                           | 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                           2                              |             
      Necrosis                             |                                                       3                  |             
      Ulcer                                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation                  |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2     1  1  2  1  1  2  1  1  2  1  1  1     1  1     1  2  1  1  2  1|             
      Thrombosis                           |                                                                      2   |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                                                                         1|             
      Hypertrophy                          |                            1                                             |             
      Vacuolization Cytoplasmic            | 1                                                              1     1   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  1                    4           1  3              1  1               |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    4  2                                                                  |             
      Cyst                                 |                                  1           2                           |             
      Pars Distalis, Hyperplasia           | 2     2        1           2                    1  2              2      |             
      Pars Distalis, Pseudocyst            |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1           1  2     1  4     2  1                             1   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 2  2  2  2  2  2  1  2  1  2  1  1  1  1  1  2  2  2  2  2  2  2  2  2  2|             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  3  2  2     1  2     3        2  1  3     2     1  2  2  2        1  1|             
      Dorsal, Cyst, Mucous                 |    3                                                                     |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9|             
                                           | 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              | 4                 4           4                                          |             
      Interstitial Cell, Hyperplasia       | 2                 3  3  1     2  1  1              1  1  1  1        4  1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2     3  3  4     2  2  3     3        2              1     3   |             
      Myelofibrosis                        |                                     1                                    |             

                                            __________________________________________________________________________|             
   Lymph Node                              |             +                          +           +  +  +           +  +|             
      Mediastinal, Hemorrhage              |                                                                         3|             
      Mediastinal, Pigmentation            |                                                                      4   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            2                                         1   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           3                              |             
      Ectasia                              |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             | 1        1                                         2        1            |             
      Hematopoietic Cell Proliferation     |                      3        3           3                          2   |             
      Infarct                              |                                                                          |             
      Necrosis                             |             2                                                            |             
      Pigmentation                         |    1                                                                     |             
      Lymphoid Follicle, Atrophy           |                                                             3           3|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  4  4     3  4  4  3  3  4  4  4  4  4     4  4  4  4  3  3  4  4  3|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                         1           2                                1   |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      3   |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                    1                     |             
      Hemorrhage                           |             2                                         2                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7| 6| 5| 6| 6| 7| 6| 6| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 2| 9| 9| 2| 3| 3| 3| 6| 2| 7| 8| 5| 1| 3| 3| 3| 6| 2| 2| 3| 0| 9|             
                                           | 9| 9| 9| 9| 0| 9| 9| 7| 0| 0| 2| 9| 6| 5| 9| 0| 0| 2| 4| 9| 3| 9| 0| 1| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    100 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                       1              2   |             
      Inflammation                         |    1  1  1        1  1  1     1  1     3        1              1     3   |             
      Alveolar Epithelium, Hyperplasia     | 4              1                                            1            |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | X                                      X  X                              |             
      Inflammation                         | 1                                1     1  1     1                        |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cataract                             |                                        2                                 |             
      Retina, Degeneration                 |                                        4                                 |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |             1                                                            |             
      Nephropathy                          | 2  2  1  1     1  2  1  3  2  1  2  1  2  2  1  2  2     1  1  1  1  1   |             
      Pigmentation                         |             1              1        2  3  1  3     3  1  3           1   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6|            |
                                           | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    100 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                   X      |      2     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X  X                                X                 X        X|      7     |
      Ulcer                                |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                             1            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X  X  X  X                          X  X     X  X     X     X  X  X|     27     |
      Clear Cell Focus                     |          X                                X                              |      4     |
      Degeneration, Cystic                 |    1                       1     1                       2               |      6  1.2|
      Eosinophilic Focus                   |          X     X                                                         |      8     |
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |          X                       X                    X                  |      4     |
      Inflammation                         |       1  1  2  1                    1     1  1     1        1        1  1|     21  1.0|
      Mixed Cell Focus                     |       X        X                    X                       X     X      |     11     |
      Necrosis                             |    1                                                                     |      4  1.8|
      Vacuolization Cytoplasmic            |       1                                1              1                  |      5  1.2|
      Bile Duct, Hyperplasia               | 2  2  1  1  2  1  3  1  3  3  2  1  2  3  1  1  2  1  1  3     2  2  1  1|     48  1.9|
      Centrilobular, Degeneration          | 2  4              2  3  1  3  2  2     2        2        1     1         |     23  2.2|
      Centrilobular, Hypertrophy           | 1     2  1                          1     1        1        1           1|     16  1.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +        +  +                                         +  +  +|  14        |
      Fat, Inflammation                    |                         3                                                |      2  2.0|
      Fat, Necrosis                        | 2                                                                 3  3   |      7  2.7|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       1        1           1     1           1        1              1   |     12  1.1|
      Cytoplasmic Alteration               |                                              1                           |      1  1.0|
      Hyperplasia                          |                                                                   3      |      2  2.5|
      Inflammation                         |                                           1                              |      2  1.0|
      Duct, Cyst                           |                                  1                                       |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration               |                                     1  1                                 |      2  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6|            |
                                           | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    100 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                            2                                             |      1  2.0|
      Ulcer                                |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                  1                                       |      3  1.3|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Ulcer                                |    1              1                                                      |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation                  |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  2  2  2  2     2        1     2  1  2  1  1  1  2  1  1  2  2  2  1|     43  1.4|
      Thrombosis                           |    3                                                                     |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                             1            |      1  1.0|
      Degeneration, Cystic                 |                            1                                             |      1  1.0|
      Hyperplasia                          |       1     1  1           2                    1  1  1        1         |      9  1.1|
      Hypertrophy                          |                                     1                                    |      2  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      3  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1                                      4  1        1  2               |     12  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         2                                                |      3  2.7|
      Cyst                                 |                                           1  1  1                       1|      6  1.2|
      Pars Distalis, Hyperplasia           |       4  2     1  2        3                             4  1           1|     15  2.0|
      Pars Distalis, Pseudocyst            |                                              2                           |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 1  1           1           1     2  1  4  2  1              4        1   |     20  1.7|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                         +|   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6|            |
                                           | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    100 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3              4                                                         |      2  3.5|
      Inflammation                         | 2  2  2  2  2  2     2  2  2  1     1  1  1  1  2  1  2  2  2  2  2  1  2|     48  1.7|
      Duct, Cyst                           |                2  4                                                      |      2  3.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |    1  3  1        1  3  2        3        1  2        2              3  2|     29  1.9|
      Dorsal, Cyst, Mucous                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    4                       4  4                                          |      6  4.0|
      Interstitial Cell, Hyperplasia       | 2     1           1  1  1     1  1              1                 1  1  1|     24  1.4|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3        2     2     2              3  2           3                 3  2|     20  2.5|
      Myelofibrosis                        |                                  2                                       |      2  1.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +        +  +  +     +        +                       +|  14        |
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                  2                                      3|      3  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      2  1.5|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |                                                             4            |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                 X              X         |      2     |
      Fibrosis                             |                                                          2               |      5  1.4|
      Hematopoietic Cell Proliferation     |                      3                                                   |      5  2.8|
      Infarct                              |                         2                                                |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              | 3  4  3  3  3  4     4  4  3           3  3  3     3  3  3  3  4  3  4  4|     43  3.5|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |             1                                4                           |      2  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6|            |
                                           | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    100 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |             1              1  4                                          |      6  1.7|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperkeratosis                       |                               2                                          |      1  2.0|
      Inflammation                         |                               2                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |    3                                                                     |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                         +|   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis                              |                                                                          |      1  1.0|
      Hemorrhage                           |                         1                                                |      3  1.7|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                      X                                                   |      1     |
      Hemorrhage                           |                   1                                      1               |      4  1.3|
      Inflammation                         | 1  2        1  1                             1              1            |     18  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                       2           1      |      5  1.8|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                          X           X   |      5     |
      Inflammation                         |                                           1              2           1   |      8  1.1|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                1                                                         |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                          |      1  1.0|
      Nephropathy                          | 1  2  2  2  1  2  1        1  2     2  1  2  2  1  2  1  2  1  1  3  2  1|     44  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88120-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   P,P'-DICHLORODIPHENYL SULFONE                               Date: 10/27/99  
Route: DOSED FEED                                                                                                 Time: 12:57:41  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 2| 6| 0| 3| 7| 2| 2| 3| 3| 2| 3| 9| 3| 3| 2| 2| 3| 3| 2| 6|            |
                                           | 9| 2| 0| 0| 9| 9| 9| 2| 3| 7| 9| 9| 0| 0| 9| 0| 1| 0| 0| 9| 9| 0| 0| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    100 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         | 1                 1        1  1           1     1  1     1        1      |     19  1.5|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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