Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5198

TDMS Study 88120-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 10/27/99       

EXPERIMENT: 88120 TEST: 03                                                                                     TIME: 13:01:27       

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        

CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B       

PATHOLOGIST: SINGER, ALLEN                                                                                     CAS: 80-07-9         

------------------------------------------------------------------------------------------------------------------------------------

                                                                                                                                    

                                                      FINAL #1 CORE STUDY RATS                                                      

                                                                                                                                    


               REASONS FOR REMOVAL:    ALL                                                                                          

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    

LAB: Battelle Columbus                                P,P'-DICHLORODIPHENYL SULFONE                            DATE: 10/27/99      

EXPERIMENT: 88120 TEST: 03                                                                                     TIME: 13:01:27      

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       

CONT: NO1-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88120B      

PATHOLOGIST: SINGER, ALLEN                                                                                     CAS: 80-07-9        
                           P,P'-DICHLORODIPHENYL SULFONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 729 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 0 PPM                                    |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      312   313   361   368   454   512   569   597   611   613                 |

 |      614   617   633   640   640   642   648   674   682   682                 |

 |      682   687   718   718   723   728                                         |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 10 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      386   410   512   585   585   592   603   617   639   659                 |

 |      663   663   669   687   696   701   708   709   718   723                 |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 30 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      400   444   482   508   523   537   549   557   562   585                 |

 |      602   614   621   646   653   663   675   676   682   691                 |

 |      691   701   708   708   708   712   715   721   723   725                 |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                           P,P'-DICHLORODIPHENYL SULFONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 729 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 100 PPM                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      490   529   537   562   569   569   569   585   602   610                 |

 |      632   633   634   659   676   677   690   691   699   701                 |

 |      722   723                                                                 |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                           P,P'-DICHLORODIPHENYL SULFONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE RATS

                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   729 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |0 PPM      |   100.0 100.0 100.0  94.0  92.0  90.0  88.0  84.0  66.0  48.0      |

 |           |                                                                    |

 |           |                                                                    |

 |10 PPM     |   100.0 100.0 100.0 100.0  96.0  96.0  94.0  86.0  76.0  60.0      |

 |           |                                                                    |

 |           |                                                                    |

 |30 PPM     |   100.0 100.0 100.0 100.0  98.0  94.0  88.0  78.0  68.0  40.0      |

 |           |                                                                    |

 |           |                                                                    |

 |100 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  82.0  72.0  56.0      |

 |           |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                0 PPM        10 PPM       30 PPM       100 PPM  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       48.0%        60.0%        40.0%        56.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.742N     P=0.252N     P=0.649      P=0.516N |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       593.8        626.3        626.1        625.4    |

 |NATURAL DEATHS (C)      |       (25.0)       (21.4)       (16.7)       (14.4)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       658.7        687.9        667.2        683.4    |

 |(STANDARD ERROR)        |       (16.1)       (11.1)       (12.3)       ( 9.7)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                           P,P'-DICHLORODIPHENYL SULFONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 730 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 0 PPM                                    |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      414   429   501   543   575   613   625   645   656   660                 |

 |      665   694   701   723                                                     |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 30 PPM                                   |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      403   429   451   540   616   633   652   659   666   666                 |

 |      680   690                                                                 |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 100 PPM                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      468   526   536   575   625   662   667   676   687   701                 |

 |      703   708   714   723   725                                               |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                           P,P'-DICHLORODIPHENYL SULFONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 730 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 300 PPM                                  |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      309   347   414   465   511   531   584   614   631   633                 |

 |      637   639   659   701   707                                               |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                           P,P'-DICHLORODIPHENYL SULFONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE RATS

                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   730 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |0 PPM      |   100.0 100.0 100.0 100.0  98.0  96.0  92.0  90.0  78.0  72.0      |

 |           |                                                                    |

 |           |                                                                    |

 |30 PPM     |   100.0 100.0 100.0 100.0  98.0  94.0  92.0  92.0  84.0  76.0      |

 |           |                                                                    |

 |           |                                                                    |

 |100 PPM    |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  92.0  88.0  70.0      |

 |           |                                                                    |

 |           |                                                                    |

 |300 PPM    |   100.0 100.0 100.0  96.0  94.0  92.0  88.0  86.0  74.0  70.0      |

 |           |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                0 PPM        30 PPM       100 PPM      300 PPM  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       72.0%        76.0%        70.0%        70.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.646      P=0.809N     P=1.000      P=0.894  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       603.1        590.4        646.4        558.8    |

 |NATURAL DEATHS (C)      |       (26.2)       (30.6)       (21.1)       (32.3)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       694.5        696.5        704.9        678.6    |

 |(STANDARD ERROR)        |       (10.8)       (11.1)       ( 8.3)       (14.7)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                   P,P'-DICHLORODIPHENYL SULFONE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        0 PPM            = 1

                                                        10 PPM           = 2

                                                        30 PPM           = 3

                                                        100 PPM          = 4



------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  104 +

      |

      | 1                                                 1           2 3            4

      |                                                               2 32    3      4      4

   96 +                                                   1      1       2    3     3    2  44

      |                                                          11                 3   32   4   4  2

      |                                                           1             1       3  3     44

      |                                                                         1        1 3 3      2 2

P  88 +                                                                                  1   3 3  1   2 2

E     |                                                                                        33 1 4  12 2

R     |                                                                                         33  4  1 12  2

C     |                                                                                          3  3  4 4   2   2

E  80 +                                                                                             3  3 4  4

N     |                                                                                                3 11

T     |                                                                                                  31 1    22

      |                                                                                                   3 113  42  2

S  72 +                                                                                                       33 4 4 22

U     |                                                                                                        3 3    22

R     |                                                                                                      11  3 3 4 22

V     |                                                                                                       1    1

I  64 +                                                                                                            1144 22

V     |                                                                                                             3344 22

A     |                                                                                                                4  2 2

L     |                                                                                                             11 3

   56 +                                                                                                              1 3314 4

      |

      |                                                                                                                  11

      |

   48 +                                                                                                                 331 1

      |

      |                                                                                                                  33

      |

   40 +                                                                                                                   3 3

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 13 obs hidden.
                                                   P,P'-DICHLORODIPHENYL SULFONE

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        0 PPM            = 1

                                                        30 PPM           = 2

                                                        100 PPM          = 3

                                                        300 PPM          = 4



----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1                                                 4             2 1       3

      |

      |                                                   4    4        2 1 1     3         3

      |

   96 +                                                        4          4 1   2      1    33

      |

      |                                                                   4     2 4    1     31    3

      |

P  92 +                                                                           4     4     1    1     2 3

E     |

R     |                                                                                 4   4      1     1 32    3

C     |

E  88 +                                                                                     4       4    1 12  2 33

N     |

T     |                                                                                             4    4 1  12 233

      |

S  84 +                                                                                                  4  4 11 223 3

U     |

R     |                                                                                                        1 1   3 3

V     |

I  80 +                                                                                                           2 2

V     |

A     |                                                                                                     44   1  22133

L     |

   76 +                                                                                                      4   4   211    2

      |

      |                                                                                                          4     13 1

      |

   72 +                                                                                                                   1 1

      |

      |                                                                                                                4  3 3

      |

   68 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 12 obs hidden.