TDMS Study 88120-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus P,P'-DICHLORODIPHENYL SULFONE DATE: 10/27/99
EXPERIMENT: 88120 TEST: 03 TIME: 13:01:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55388 ROUTE: DOSED FEED NTP C#: 88120B
PATHOLOGIST: SINGER, ALLEN CAS: 80-07-9
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 CORE STUDY RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus P,P'-DICHLORODIPHENYL SULFONE DATE: 10/27/99
EXPERIMENT: 88120 TEST: 03 TIME: 13:01:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55388 ROUTE: DOSED FEED NTP C#: 88120B
PATHOLOGIST: SINGER, ALLEN CAS: 80-07-9
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 312 313 361 368 454 512 569 597 611 613 |
| 614 617 633 640 640 642 648 674 682 682 |
| 682 687 718 718 723 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 386 410 512 585 585 592 603 617 639 659 |
| 663 663 669 687 696 701 708 709 718 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 400 444 482 508 523 537 549 557 562 585 |
| 602 614 621 646 653 663 675 676 682 691 |
| 691 701 708 708 708 712 715 721 723 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 490 529 537 562 569 569 569 585 602 610 |
| 632 633 634 659 676 677 690 691 699 701 |
| 722 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 94.0 92.0 90.0 88.0 84.0 66.0 48.0 |
| | |
| | |
|10 PPM | 100.0 100.0 100.0 100.0 96.0 96.0 94.0 86.0 76.0 60.0 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 88.0 78.0 68.0 40.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 82.0 72.0 56.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 10 PPM 30 PPM 100 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 48.0% 60.0% 40.0% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.742N P=0.252N P=0.649 P=0.516N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 593.8 626.3 626.1 625.4 |
|NATURAL DEATHS (C) | (25.0) (21.4) (16.7) (14.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 658.7 687.9 667.2 683.4 |
|(STANDARD ERROR) | (16.1) (11.1) (12.3) ( 9.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 414 429 501 543 575 613 625 645 656 660 |
| 665 694 701 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 403 429 451 540 616 633 652 659 666 666 |
| 680 690 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 468 526 536 575 625 662 667 676 687 701 |
| 703 708 714 723 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 309 347 414 465 511 531 584 614 631 633 |
| 637 639 659 701 707 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P,P'-DICHLORODIPHENYL SULFONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 90.0 78.0 72.0 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 92.0 92.0 84.0 76.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 92.0 88.0 70.0 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 96.0 94.0 92.0 88.0 86.0 74.0 70.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 30 PPM 100 PPM 300 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 76.0% 70.0% 70.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.646 P=0.809N P=1.000 P=0.894 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.1 590.4 646.4 558.8 |
|NATURAL DEATHS (C) | (26.2) (30.6) (21.1) (32.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 694.5 696.5 704.9 678.6 |
|(STANDARD ERROR) | (10.8) (11.1) ( 8.3) (14.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P,P'-DICHLORODIPHENYL SULFONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
10 PPM = 2
30 PPM = 3
100 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 1 2 3 4
| 2 32 3 4 4
96 + 1 1 2 3 3 2 44
| 11 3 32 4 4 2
| 1 1 3 3 44
| 1 1 3 3 2 2
P 88 + 1 3 3 1 2 2
E | 33 1 4 12 2
R | 33 4 1 12 2
C | 3 3 4 4 2 2
E 80 + 3 3 4 4
N | 3 11
T | 31 1 22
| 3 113 42 2
S 72 + 33 4 4 22
U | 3 3 22
R | 11 3 3 4 22
V | 1 1
I 64 + 1144 22
V | 3344 22
A | 4 2 2
L | 11 3
56 + 1 3314 4
|
| 11
|
48 + 331 1
|
| 33
|
40 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
P,P'-DICHLORODIPHENYL SULFONE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
30 PPM = 2
100 PPM = 3
300 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1 3
|
| 4 4 2 1 1 3 3
|
96 + 4 4 1 2 1 33
|
| 4 2 4 1 31 3
|
P 92 + 4 4 1 1 2 3
E |
R | 4 4 1 1 32 3
C |
E 88 + 4 4 1 12 2 33
N |
T | 4 4 1 12 233
|
S 84 + 4 4 11 223 3
U |
R | 1 1 3 3
V |
I 80 + 2 2
V |
A | 44 1 22133
L |
76 + 4 4 211 2
|
| 4 13 1
|
72 + 1 1
|
| 4 3 3
|
68 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.