TDMS Study 88122-07 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Battelle Columbus ELMIRON DATE: 04/24/01
EXPERIMENT: 88122 TEST: 07 TIME: 17:03:25
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C88122
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Final#1/Mice
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BATTELLE COLUMBUS LABORATORY ELMIRON DATE: 04/24/01
EXPERIMENT: 88122 TEST: 07 TIME: 17:12:01
SPECIES: MICE, B6C3F1
TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: C88122
CONT: NO1-ES-55388 CAS: 37319-17-8
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
TWO YEAR ORAL GAVAGE STUDY OF ELMIRON
==========================================================================================================
WEEK 0 MG/KG 56 MG/KG 168 MG/KG 504 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 22.8 50 22.5 98.7 50 22.8 100.0 50 22.7 99.6 50
1 22.8 50 22.5 98.7 50 22.8 100.0 50 22.7 99.6 50
5 28.3 50 27.8 98.2 49 28.5 100.7 50 28.4 100.4 48
9 33.3 50 32.2 96.7 49 32.9 98.8 50 33.9 101.8 48
13 37.0 50 35.2 95.1 49 36.4 98.4 50 36.5 98.6 48
17 40.6 50 38.8 95.6 49 39.9 98.3 50 40.4 99.5 48
21 42.7 50 41.1 96.3 49 43.5 101.9 50 43.3 101.4 48
25 46.9 50 44.7 95.3 49 46.5 99.1 50 47.1 100.4 48
29 48.4 50 46.6 96.3 49 48.2 99.6 50 48.7 100.6 48
33 49.0 50 47.3 96.5 49 49.3 100.6 50 49.9 101.8 48
37 49.4 50 47.9 97.0 49 49.4 100.0 50 50.0 101.2 48
41 50.9 50 49.8 97.8 49 51.3 100.8 50 51.9 102.0 48
45 51.3 50 49.7 96.9 49 51.7 100.8 50 52.3 101.9 48
49 51.9 50 50.1 96.5 48 51.9 100.0 50 52.1 100.4 48
53 52.3 50 50.8 97.1 47 52.6 100.6 50 52.7 100.8 48
57 52.5 50 51.3 97.7 47 53.0 101.0 50 52.7 100.4 48
61 51.9 49 51.1 98.5 47 51.8 99.8 50 52.7 101.5 48
65 52.3 49 51.7 98.9 47 52.6 100.6 50 52.9 101.1 48
69 51.9 49 51.4 99.0 46 52.4 101.0 49 51.8 99.8 48
73 51.5 48 50.6 98.3 46 51.4 99.8 49 51.6 100.2 45
77 50.7 48 50.8 100.2 43 50.2 99.0 49 49.9 98.4 45
81 51.1 48 50.4 98.6 43 49.8 97.5 48 49.9 97.7 44
85 51.0 48 51.3 100.6 43 50.3 98.6 47 49.9 97.8 42
89 52.2 45 51.3 98.3 43 50.8 97.3 44 50.5 96.7 40
93 51.2 43 50.6 98.8 43 50.3 98.2 42 49.0 95.7 37
97 50.4 41 48.7 96.6 43 49.5 98.2 40 49.1 97.4 33
100 49.2 40 47.4 96.3 42 48.3 98.2 39 47.1 95.7 31
TERM. SAC. 39 40 38 30
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
TWO YEAR ORAL GAVAGE STUDY OF ELMIRON
==========================================================================================================
WEEK 0 MG/KG 56 MG/KG 168 MG/KG 504 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 18.5 50 18.4 99.5 50 18.6 100.5 50 18.5 100.0 50
1 18.5 50 18.4 99.5 50 18.6 100.5 50 18.5 100.0 50
5 21.0 50 22.0 104.8 49 22.7 108.1 50 22.3 106.2 50
9 26.2 50 24.9 95.0 49 26.4 100.8 50 25.9 98.9 50
13 29.8 50 28.7 96.3 49 29.3 98.3 50 29.6 99.3 50
17 33.4 50 32.4 97.0 49 32.6 97.6 50 32.9 98.5 50
21 36.2 50 34.9 96.4 49 36.1 99.7 50 36.2 100.0 50
25 39.9 50 39.4 98.7 49 39.1 98.0 50 39.7 99.5 50
29 43.1 49 42.9 99.5 49 42.7 99.1 50 43.7 101.4 50
33 45.0 49 45.2 100.4 49 44.5 98.9 50 45.3 100.7 50
37 48.2 49 48.0 99.6 49 47.3 98.1 50 48.3 100.2 50
41 51.1 49 51.7 101.2 48 50.7 99.2 50 51.5 100.8 50
45 54.6 49 54.8 100.4 48 53.3 97.6 50 54.3 99.5 50
49 57.6 49 57.2 99.3 48 56.5 98.1 49 56.2 97.6 50
53 58.5 49 58.4 99.8 48 57.7 98.6 49 56.9 97.3 50
57 59.8 49 59.8 100.0 48 59.9 100.2 49 57.0 95.3 50
61 61.2 48 60.7 99.2 48 60.5 98.9 49 57.0 93.1 49
65 61.7 48 60.9 98.7 48 61.0 98.9 49 57.1 92.5 49
69 62.9 47 61.0 97.0 48 61.0 97.0 49 55.4 88.1 49
73 61.4 47 60.6 98.7 47 60.4 98.4 48 53.9 87.8 49
77 59.9 47 58.8 98.2 47 58.3 97.3 47 52.0 86.8 47
81 61.1 46 58.1 95.1 45 58.3 95.4 47 49.9 81.7 47
85 59.7 45 58.2 97.5 45 58.2 97.5 46 49.0 82.1 46
89 61.4 45 58.6 95.4 45 58.3 95.0 45 48.0 78.2 46
93 61.0 44 57.4 94.1 44 57.9 94.9 42 47.5 77.9 44
97 62.0 41 56.4 91.0 44 57.2 92.3 39 45.9 74.0 41
100 60.9 40 55.2 90.6 42 56.0 92.0 38 43.9 72.1 40
TERM. SAC. 37 38 37 34
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.