Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5463

TDMS Study 88124-01 Pathology Tables

NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40

                                                  FINAL#2, 13 WEEK SUBCHRONIC




       Facility:  Battelle Northwest

       Chemical CAS #:  22398-80-7

       Lock Date:  01/24/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (1)          (2)          (1)          (2)          (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)      1 (100%)     2 (100%)     1 (100%)     2 (100%)     7 (70%)     
      Necrosis                                                                                                          1 (10%)     
      Pigmentation, Hemosiderin                                                                                         6 (60%)     
      Hepatocyte, Centrilobular, Atrophy                                                                                8 (80%)     
      Hepatocyte, Centrilobular, Necrosis                                                                               9 (90%)     
   Mesentery                                                       (1)          (1)                                                 
      Fat, Necrosis                                                 1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                   3 (30%)      1 (10%)      1 (10%)      2 (20%)      3 (30%)                  
      Hypertrophy                                                                                                      10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage                                                                                                        1 (10%)     
      Zona Fasciculata, Vacuolization Cytoplasmic                                                          1 (10%)      4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)                                                             (10)         
      Inflammation, Chronic                            1 (10%)                                                                      
   Ovary                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
      Cyst                                                                                    1 (10%)      1 (10%)                  

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Periovarian Tissue, Cyst                                                   1 (10%)                                            
   Uterus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                                                          3 (30%)     10 (100%)    
      Inflammation, Granulomatous                      2 (20%)      1 (10%)      1 (10%)      1 (10%)                               
   Lymph Node, Bronchial                              (7)          (9)          (10)         (10)         (10)         (9)          
      Hyperplasia                                                   7 (78%)      7 (70%)      9 (90%)     10 (100%)     5 (56%)     
      Pigmentation                                                  8 (89%)     10 (100%)     9 (90%)     10 (100%)     9 (100%)    
   Lymph Node, Mandibular                             (9)                                                 (9)          (9)          
      Atrophy                                                                                                           5 (56%)     
   Lymph Node, Mesenteric                             (10)         (9)          (10)         (10)         (10)         (9)          
      Inflammation, Granulomatous                                                             1 (10%)                               
   Lymph Node, Mediastinal                            (7)          (9)          (8)          (5)          (9)          (8)          
      Atrophy                                                                                                           1 (13%)     
      Hyperplasia                                                   8 (89%)      8 (100%)     4 (80%)      5 (56%)      7 (88%)     
      Pigmentation                                                  8 (89%)      8 (100%)     5 (100%)     7 (78%)      8 (100%)    
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                                                                                  9 (90%)     
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Atrophy                                                                                                           9 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)     9 (90%)      9 (90%)     
      Hyperplasia                                                                                                       1 (10%)     
      Inflammation, Acute                                                                                               1 (10%)     
      Inflammation, Chronic                                         2 (20%)      6 (60%)      9 (90%)      9 (90%)                  
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                  9 (90%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Inflammation, Chronic Active                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolar Epithelium, Hyperplasia                             10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolus, Infiltration Cellular, Histiocyte      3 (30%)                                                                      
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Interstitium, Fibrosis                                                    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                  3 (30%)      2 (20%)      7 (70%)      9 (90%)     10 (100%)    
      Inflammation, Chronic                                         1 (10%)                   1 (10%)      3 (30%)                  
      Nasolacrimal Duct, Inflammation, Acute                                                  1 (10%)                               
   Trachea                                            (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                                            3 (30%)      7 (70%)      7 (70%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                  10 (100%)     8 (80%)      9 (90%)      9 (90%)      8 (80%)      7 (70%)     
      Nephropathy                                      1 (10%)                                1 (10%)      1 (10%)     10 (100%)    
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            9           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (1)          (1)          (1)                       (10)         
      Eosinophilic Focus                                                                                                1 (10%)     
      Hematopoietic Cell Proliferation                                                                                  1 (10%)     
      Hepatodiaphragmatic Nodule                       1 (10%)      1 (100%)     1 (100%)     1 (100%)                  4 (40%)     
      Infiltration Cellular, Mononuclear Cell                                                                           1 (10%)     
      Pigmentation, Hemosiderin                                                                                         2 (20%)     
      Bile Duct, Hyperplasia                                                                                            2 (20%)     
      Hepatocyte, Centrilobular, Atrophy                                                                                6 (60%)     
      Hepatocyte, Centrilobular, Necrosis                                                                               5 (50%)     
   Mesentery                                                                                 (1)          (1)                       
      Fat, Necrosis                                                                           1 (100%)     1 (100%)                 
   Pancreas                                           (10)                                                             (10)         
      Acinus, Atrophy                                                                                                   1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                   6 (60%)      7 (70%)      6 (60%)      3 (30%)      5 (50%)      2 (20%)     
      Hypertrophy                                                                                                       8 (80%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)         (10)         
      Zona Fasciculata, Vacuolization Cytoplasmic                                                                      10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)         (10)         (10)         
      Degeneration                                                                                                     10 (100%)    
   Prostate                                           (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
   Seminal Vesicle                                    (10)         (10)         (10)         (10)         (10)         (9)          
      Atrophy                                                                                                           9 (100%)    
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                                             1 (10%)                                            
      Germinal Epithelium, Degeneration                                                                                 5 (50%)     
      Sertoli Cell, Degeneration                                                 1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperplasia                                                                                                      10 (100%)    
   Lymph Node, Bronchial                              (9)          (10)         (8)          (10)         (10)         (9)          
      Hyperplasia                                                   5 (50%)      4 (50%)      3 (30%)      6 (60%)      3 (33%)     
      Pigmentation                                                  9 (90%)      8 (100%)    10 (100%)    10 (100%)     9 (100%)    
   Lymph Node, Mandibular                             (10)                                                (8)          (10)         
      Atrophy                                                                                                           6 (60%)     
   Lymph Node, Mediastinal                            (9)          (5)          (8)          (10)         (8)          (10)         
      Hyperplasia                                                   3 (60%)      7 (88%)      8 (80%)      6 (75%)      8 (80%)     
      Pigmentation                                                  4 (80%)      8 (100%)     9 (90%)      7 (88%)      9 (90%)     
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                                                                                 10 (100%)    
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Atrophy                                                                                                           8 (89%)     
      Hemorrhage                                       1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (1)                                                 (10)         
      Ulcer                                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88124-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  INDIUM PHOSPHIDE                                     Date: 02/22/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:02:40  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      1.0          3.0          10.0         30.0         100.0           
                                                                MG/M3        MG/M3        MG/M3        MG/M3        MG/M3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)     9 (90%)     
      Inflammation, Chronic                                                      5 (50%)      8 (80%)      9 (90%)                  
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Inflammation, Chronic Active                                 10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolar Epithelium, Hyperplasia                             10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Alveolus, Infiltration Cellular, Histiocyte      4 (40%)                                                                      
      Alveolus, Proteinosis                                        10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Interstitium, Fibrosis                                                    10 (100%)    10 (100%)     9 (90%)     10 (100%)    
      Serosa, Hemorrhage                               1 (10%)                                                                      
   Nose                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                  1 (10%)      1 (10%)      8 (80%)      8 (80%)     10 (100%)    
   Trachea                                            (10)         (10)         (10)         (10)         (10)         (10)         
      Foreign Body                                                               1 (10%)      2 (20%)      5 (50%)      8 (80%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Nephropathy                                      7 (70%)      4 (40%)      5 (50%)      1 (10%)      4 (40%)     10 (100%)    
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 41042-41042/41042


--multipart-boundary--