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TDMS Study 88124-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99       
EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 14:03:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                      FINAL#1 CORE STUDY RATS                                                       
                                                                                                                                    

               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99

EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 14:03:52
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7

Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Brain
                                                 Clitoral/Preputial Gland
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Prostate
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 10/28/99     
EXPERIMENT: 88124 TEST: 03                                                                                     TIME: 14:03:52     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 22398-80-7    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 INDIUM PHOSPHIDE
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Medulla                        Pheochromocytoma Benign
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS
Lung                                   Alveolar/Bronchiolar Adenoma
                                       Alveolar/Bronchiolar Carcinoma
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                                       Squamous Cell Carcinoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Carcinoma or Adenoma
Skin                                   Fibroma
                                       Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
Testes                                 Adenoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Malignant Tumors
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Medulla                        Pheochromocytoma Benign
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS
Lung                                   Alveolar/Bronchiolar Adenoma
                                       Alveolar/Bronchiolar Carcinoma
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland                          Carcinoma
                                       Fibroadenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Oral Mucosa                            Squamous Cell Carcinoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
===============================================================
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  22/50 (44%)  16/49 (33%)  23/50 (46%) |2/50 (4%)    6/48 (13%)   2/50 (4%)    9/49 (18%)   |
|POLY-3 ADJUSTED (b)|     23.8%        48.8%        38.0%        51.1%       |4.6%         14.5%        4.5%         20.6%        |
|TERMINAL (d)       |     6/27 (22%)   17/29 (59%)  11/28 (39%)  15/26 (58%) |1/34 (3%)    4/31 (13%)   2/36 (6%)    6/34 (18%)   |
|FIRST INCIDENCE    |     537          635          537          525         |615          686          735 (T)      588          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.026 *    P=0.022 *    P=0.163      P=0.008 **  |P=0.031 *    P=0.124      P=0.674N     P=0.031 *    |
|POLY 3             |     P=0.044 *    P=0.011 *    P=0.117      P=0.006 **  |P=0.026 *    P=0.119      P=0.682N     P=0.026 *    |
|POLY 1.5           |     P=0.042 *    P=0.010 *    P=0.118      P=0.006 **  |P=0.027 *    P=0.117      P=0.686N     P=0.025 *    |
|POLY 6             |     P=0.045 *    P=0.013 *    P=0.119      P=0.006 **  |P=0.026 *    P=0.123      P=0.678N     P=0.025 *    |
|LOGISTIC REGRESSION|     P=0.038 *    P=0.018 *    P=0.123      P=0.007 **  |P=0.028 *    P=0.120      P=0.687N     P=0.027 *    |
|COCH-ARM / FISHERS |     P=0.036 *    P=0.009 **   P=0.115      P=0.005 **  |P=0.026 *    P=0.121      P=0.691N     P=0.023 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    3/49 (6%)    1/50 (2%)   |0/50 (0%)    0/48 (0%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.8%         7.4%         2.3%        |0.0%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     0/27 (0%)    2/29 (7%)    2/28 (7%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    1/34 (3%)    |
|FIRST INCIDENCE    |     ---          628          698          684         |---          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.576N     P=0.142      P=0.129      P=0.506     |P=0.218      (e)          (e)          P=0.500      |
|POLY 3             |     P=0.526N     P=0.136      P=0.119      P=0.511     |P=0.217      (e)          (e)          P=0.501      |
|POLY 1.5           |     P=0.531N     P=0.130      P=0.118      P=0.508     |P=0.218      (e)          (e)          P=0.501      |
|POLY 6             |     P=0.524N     P=0.144      P=0.120      P=0.513     |P=0.216      (e)          (e)          P=0.500      |
|LOGISTIC REGRESSION|     P=0.544N     P=0.129      P=0.121      P=0.503     |(e)          (e)          (e)          P=0.500      |
|COCH-ARM / FISHERS |     P=0.549N     P=0.121      P=0.117      P=0.500     |P=0.213      (e)          (e)          P=0.495      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  26/50 (52%)  18/49 (37%)  24/50 (48%) |2/50 (4%)    6/48 (13%)   2/50 (4%)    9/49 (18%)   |
|POLY-3 ADJUSTED (b)|     23.8%        57.1%        42.6%        53.1%       |4.6%         14.5%        4.5%         20.6%        |
|TERMINAL (d)       |     6/27 (22%)   19/29 (66%)  12/28 (43%)  15/26 (58%) |1/34 (3%)    4/31 (13%)   2/36 (6%)    6/34 (18%)   |
|FIRST INCIDENCE    |     537          628          537          525         |615          686          735 (T)      588          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.041 *    P=0.004 **   P=0.086      P=0.005 **  |P=0.031 *    P=0.124      P=0.674N     P=0.031 *    |
|POLY 3             |     P=0.070      P<0.001 **   P=0.051      P=0.003 **  |P=0.026 *    P=0.119      P=0.682N     P=0.026 *    |
|POLY 1.5           |     P=0.065      P<0.001 **   P=0.052      P=0.003 **  |P=0.027 *    P=0.117      P=0.686N     P=0.025 *    |
|POLY 6             |     P=0.074      P<0.001 **   P=0.052      P=0.003 **  |P=0.026 *    P=0.123      P=0.678N     P=0.025 *    |
|LOGISTIC REGRESSION|     P=0.058      P=0.002 **   P=0.056      P=0.004 **  |P=0.028 *    P=0.120      P=0.687N     P=0.027 *    |
|COCH-ARM / FISHERS |     P=0.055      P<0.001 **   P=0.052      P=0.003 **  |P=0.026 *    P=0.121      P=0.691N     P=0.023 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.2%         0.0%         2.4%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     408          ---          435          671         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.434N     P=0.109N     P=0.296N     P=0.284N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.453N     P=0.110N     P=0.302N     P=0.298N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.448N     P=0.113N     P=0.301N     P=0.298N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.460N     P=0.107N     P=0.303N     P=0.301N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.573N     P=0.169N     P=0.398N     P=0.407N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.442N     P=0.121N     P=0.309N     P=0.309N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.2%         0.0%         4.7%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     408          ---          435          671         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.428N     P=0.109N     P=0.487N     P=0.284N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.447N     P=0.110N     P=0.494N     P=0.298N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.441N     P=0.113N     P=0.494N     P=0.298N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.455N     P=0.107N     P=0.494N     P=0.301N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.550N     P=0.169N     P=0.596N     P=0.407N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.437N     P=0.121N     P=0.500N     P=0.309N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |5/49 (10%)   4/47 (9%)    4/47 (9%)    6/49 (12%)   |
|POLY-3 ADJUSTED (b)|     2.5%         4.5%         0.0%         0.0%        |12.0%        10.2%        9.5%         14.0%        |
|TERMINAL (d)       |     1/27 (4%)    2/29 (7%)    0/29 (0%)    0/26 (0%)   |5/33 (15%)   4/29 (14%)   4/35 (11%)   6/34 (18%)   |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          ---         |735 (T)      735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.218N     P=0.525      P=0.486N     P=0.508N    |P=0.411      P=0.582N     P=0.463N     P=0.521      |
|POLY 3             |     P=0.202N     P=0.530      P=0.495N     P=0.490N    |P=0.395      P=0.538N     P=0.492N     P=0.520      |
|POLY 1.5           |     P=0.204N     P=0.519      P=0.496N     P=0.492N    |P=0.394      P=0.539N     P=0.505N     P=0.518      |
|POLY 6             |     P=0.201N     P=0.542      P=0.493N     P=0.489N    |P=0.392      P=0.538N     P=0.477N     P=0.520      |
|LOGISTIC REGRESSION|     P=0.218N     P=0.525      (e)          (e)         |P=0.411      P=0.582N     P=0.463N     P=0.521      |
|COCH-ARM / FISHERS |     P=0.209N     P=0.500      P=0.500N     P=0.500N    |P=0.371      P=0.527N     P=0.527N     P=0.500      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    3/47 (6%)    3/47 (6%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.8%         0.0%         2.4%         0.0%        |0.0%         7.4%         7.1%         0.0%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    1/29 (3%)    0/26 (0%)   |0/33 (0%)    1/29 (3%)    3/35 (9%)    0/34 (0%)    |
|FIRST INCIDENCE    |     537          ---          733 (T)      ---         |---          428          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.274N     P=0.219N     P=0.483N     P=0.227N    |P=0.274N     P=0.116      P=0.131      (e)          |
|POLY 3             |     P=0.280N     P=0.223N     P=0.499N     P=0.231N    |P=0.272N     P=0.113      P=0.120      (e)          |
|POLY 1.5           |     P=0.276N     P=0.228N     P=0.497N     P=0.231N    |P=0.273N     P=0.111      P=0.117      (e)          |
|POLY 6             |     P=0.286N     P=0.219N     P=0.501N     P=0.233N    |P=0.272N     P=0.115      P=0.125      (e)          |
|LOGISTIC REGRESSION|     P=0.289N     P=0.287N     P=0.519N     P=0.292N    |P=0.304N     P=0.128      P=0.131      (e)          |
|COCH-ARM / FISHERS |     P=0.271N     P=0.247N     P=0.500N     P=0.247N    |P=0.286N     P=0.113      P=0.113      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |5/49 (10%)   7/47 (15%)   7/47 (15%)   6/49 (12%)   |
|POLY-3 ADJUSTED (b)|     7.3%         4.5%         2.4%         0.0%        |12.0%        17.3%        16.6%        14.0%        |
|TERMINAL (d)       |     1/27 (4%)    2/29 (7%)    1/29 (3%)    0/26 (0%)   |5/33 (15%)   5/29 (17%)   7/35 (20%)   6/34 (18%)   |
|FIRST INCIDENCE    |     537          733 (T)      733 (T)      ---         |735 (T)      428          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.091N     P=0.464N     P=0.289N     P=0.119N    |P=0.526N     P=0.306      P=0.419      P=0.521      |
|POLY 3             |     P=0.087N     P=0.471N     P=0.304N     P=0.113N    |P=0.554N     P=0.359      P=0.387      P=0.520      |
|POLY 1.5           |     P=0.086N     P=0.480N     P=0.302N     P=0.114N    |P=0.551N     P=0.350      P=0.373      P=0.518      |
|POLY 6             |     P=0.089N     P=0.463N     P=0.305N     P=0.115N    |P=0.560N     P=0.368      P=0.404      P=0.520      |
|LOGISTIC REGRESSION|     P=0.086N     P=0.508N     P=0.310N     P=0.136N    |P=0.545N     P=0.340      P=0.419      P=0.521      |
|COCH-ARM / FISHERS |     P=0.086N     P=0.500N     P=0.309N     P=0.121N    |P=0.572      P=0.350      P=0.350      P=0.500      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Schwannoma Benign                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         0.0%         2.4%        |0.0%         2.4%         0.0%         4.7%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    1/26 (4%)   |0/34 (0%)    1/31 (3%)    0/36 (0%)    2/34 (6%)    |
|FIRST INCIDENCE    |     672          ---          ---          733 (T)     |---          735 (T)      ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.529      P=0.463N     P=0.506N     P=0.755N    |P=0.156      P=0.482      (e)          P=0.238      |
|POLY 3             |     P=0.529      P=0.484N     P=0.496N     P=0.751N    |P=0.151      P=0.498      (e)          P=0.238      |
|POLY 1.5           |     P=0.533      P=0.489N     P=0.497N     P=0.753N    |P=0.152      P=0.497      (e)          P=0.238      |
|POLY 6             |     P=0.523      P=0.478N     P=0.495N     P=0.752N    |P=0.150      P=0.498      (e)          P=0.237      |
|LOGISTIC REGRESSION|     P=0.539      P=0.505N     P=0.500N     P=0.753N    |(e)          P=0.482      (e)          P=0.238      |
|COCH-ARM / FISHERS |     P=0.536      P=0.500N     P=0.500N     P=0.753N    |P=0.151      P=0.500      (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         4.5%         4.8%         7.0%        |2.3%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    2/29 (7%)    2/26 (8%)   |1/34 (3%)    0/31 (0%)    0/36 (0%)    1/34 (3%)    |
|FIRST INCIDENCE    |     733 (T)      701          733 (T)      658         |735 (T)      ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.246      P=0.534      P=0.525      P=0.310     |P=0.544      P=0.518N     P=0.489N     P=0.762      |
|POLY 3             |     P=0.279      P=0.531      P=0.509      P=0.325     |P=0.539      P=0.502N     P=0.491N     P=0.760N     |
|POLY 1.5           |     P=0.279      P=0.520      P=0.507      P=0.320     |P=0.539      P=0.503N     P=0.494N     P=0.760N     |
|POLY 6             |     P=0.278      P=0.544      P=0.512      P=0.328     |P=0.537      P=0.502N     P=0.488N     P=0.760N     |
|LOGISTIC REGRESSION|     P=0.266      P=0.547      P=0.525      P=0.323     |P=0.544      (e)          (e)          P=0.762      |
|COCH-ARM / FISHERS |     P=0.269      P=0.500      P=0.500      P=0.309     |P=0.532      P=0.500N     P=0.500N     P=0.747      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    4/50 (8%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         9.5%         7.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    2/29 (7%)    1/26 (4%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     617          ---          649          684         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.240      P=0.214N     P=0.366      P=0.501     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.246      P=0.221N     P=0.349      P=0.519     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.250      P=0.226N     P=0.346      P=0.516     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.238      P=0.216N     P=0.353      P=0.520     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.252      P=0.249N     P=0.341      P=0.510     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.249      P=0.247N     P=0.339      P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    6/50 (12%)   6/50 (12%)  |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     7.3%         4.5%         14.3%        14.0%       |2.3%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    4/29 (14%)   3/26 (12%)  |1/34 (3%)    0/31 (0%)    0/36 (0%)    1/34 (3%)    |
|FIRST INCIDENCE    |     617          701          649          658         |735 (T)      ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.113      P=0.452N     P=0.278      P=0.253     |P=0.544      P=0.518N     P=0.489N     P=0.762      |
|POLY 3             |     P=0.126      P=0.465N     P=0.253      P=0.265     |P=0.539      P=0.502N     P=0.491N     P=0.760N     |
|POLY 1.5           |     P=0.128      P=0.477N     P=0.251      P=0.260     |P=0.539      P=0.503N     P=0.494N     P=0.760N     |
|POLY 6             |     P=0.122      P=0.454N     P=0.257      P=0.267     |P=0.537      P=0.502N     P=0.488N     P=0.760N     |
|LOGISTIC REGRESSION|     P=0.127      P=0.478N     P=0.253      P=0.263     |P=0.544      (e)          (e)          P=0.762      |
|COCH-ARM / FISHERS |     P=0.124      P=0.500N     P=0.243      P=0.243     |P=0.532      P=0.500N     P=0.500N     P=0.747      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   13/50 (26%)  27/50 (54%)  30/50 (60%) |0/50 (0%)    7/50 (14%)   5/50 (10%)   19/50 (38%)  |
|POLY-3 ADJUSTED (b)|     14.8%        29.1%        62.9%        67.0%       |0.0%         16.5%        11.2%        43.6%        |
|TERMINAL (d)       |     4/27 (15%)   8/29 (28%)   21/29 (72%)  20/26 (77%) |0/34 (0%)    5/31 (16%)   5/36 (14%)   17/34 (50%)  |
|FIRST INCIDENCE    |     697          685          644          525         |---          694          735 (T)      610          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.106      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.008 **   P=0.038 *    P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.090      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.007 **   P=0.034 *    P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.078      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.007 **   P=0.033 *    P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.105      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.007 **   P=0.036 *    P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.106      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.009 **   P=0.038 *    P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.062      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.006 **   P=0.028 *    P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    10/50 (20%)  8/50 (16%)   16/50 (32%) |1/50 (2%)    3/50 (6%)    1/50 (2%)    11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     2.5%         22.4%        19.3%        36.5%       |2.3%         7.1%         2.2%         25.3%        |
|TERMINAL (d)       |     0/27 (0%)    6/29 (21%)   7/29 (24%)   9/26 (35%)  |1/34 (3%)    1/31 (3%)    1/36 (3%)    10/34 (29%)  |
|FIRST INCIDENCE    |     639          635          710          621         |735 (T)      695          735 (T)      519          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.010 *    P=0.024 *    P<0.001 **  |P<0.001 **   P=0.289      P=0.749N     P=0.003 **   |
|POLY 3             |     P<0.001 **   P=0.006 **   P=0.016 *    P<0.001 **  |P<0.001 **   P=0.302      P=0.751N     P=0.002 **   |
|POLY 1.5           |     P<0.001 **   P=0.005 **   P=0.016 *    P<0.001 **  |P<0.001 **   P=0.300      P=0.754N     P=0.002 **   |
|POLY 6             |     P<0.001 **   P=0.007 **   P=0.016 *    P<0.001 **  |P<0.001 **   P=0.305      P=0.747N     P=0.002 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.008 **   P=0.019 *    P<0.001 **  |P<0.001 **   P=0.301      P=0.749N     P=0.003 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.004 **   P=0.015 *    P<0.001 **  |P<0.001 **   P=0.309      P=0.753N     P=0.002 **   |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   22/50 (44%)  30/50 (60%)  35/50 (70%) |1/50 (2%)    10/50 (20%)  6/50 (12%)   26/50 (52%)  |
|POLY-3 ADJUSTED (b)|     17.1%        48.7%        69.8%        76.1%       |2.3%         23.5%        13.5%        58.8%        |
|TERMINAL (d)       |     4/27 (15%)   14/29 (48%)  24/29 (83%)  21/26 (81%) |1/34 (3%)    6/31 (19%)   6/36 (17%)   23/34 (68%)  |
|FIRST INCIDENCE    |     639          635          644          525         |735 (T)      694          735 (T)      519          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.005 **   P=0.066      P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.004 **   P=0.063      P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.004 **   P=0.060      P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.004 **   P=0.065      P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.005 **   P=0.066      P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.004 **   P=0.056      P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         9.1%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          545         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.002 **   (e)          (e)          P=0.075     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.002 **   (e)          (e)          P=0.071     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.002 **   (e)          (e)          P=0.068     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.002 **   (e)          (e)          P=0.075     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   (e)          (e)          P=0.035 *   |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.002 **   (e)          (e)          P=0.059     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    8/50 (16%)   3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.4%         2.4%        |0.0%         18.9%        6.7%         4.7%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    1/29 (3%)    1/26 (4%)   |0/34 (0%)    6/31 (19%)   1/36 (3%)    2/34 (6%)    |
|FIRST INCIDENCE    |     ---          ---          733 (T)      733 (T)     |---          683          714          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.285      (e)          P=0.514      P=0.492     |P=0.336N     P=0.004 **   P=0.136      P=0.238      |
|POLY 3             |     P=0.306      (e)          P=0.505      P=0.510     |P=0.344N     P=0.003 **   P=0.127      P=0.238      |
|POLY 1.5           |     P=0.308      (e)          P=0.504      P=0.508     |P=0.344N     P=0.003 **   P=0.124      P=0.238      |
|POLY 6             |     P=0.303      (e)          P=0.507      P=0.511     |P=0.345N     P=0.003 **   P=0.131      P=0.237      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.514      P=0.492     |P=0.346N     P=0.004 **   P=0.130      P=0.238      |
|COCH-ARM / FISHERS |     P=0.303      (e)          P=0.500      P=0.500     |P=0.350N     P=0.003 **   P=0.121      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |20/50 (40%)  19/50 (38%)  18/50 (36%)  12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     5.0%         2.3%         0.0%         2.4%        |46.1%        44.0%        38.8%        27.7%        |
|TERMINAL (d)       |     2/27 (7%)    1/29 (3%)    0/29 (0%)    1/26 (4%)   |18/34 (53%)  15/31 (48%)  12/36 (33%)  11/34 (32%)  |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          733 (T)     |590          580          566          593          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.523N     P=0.475N     P=0.222N     P=0.513N    |P=0.035N*    P=0.533      P=0.328N     P=0.059N     |
|POLY 3             |     P=0.505N     P=0.470N     P=0.231N     P=0.483N    |P=0.036N*    P=0.509N     P=0.312N     P=0.056N     |
|POLY 1.5           |     P=0.502N     P=0.481N     P=0.233N     P=0.487N    |P=0.036N*    P=0.519N     P=0.354N     P=0.058N     |
|POLY 6             |     P=0.510N     P=0.458N     P=0.229N     P=0.481N    |P=0.038N*    P=0.497N     P=0.262N     P=0.055N     |
|LOGISTIC REGRESSION|     P=0.523N     P=0.475N     (e)          P=0.513N    |P=0.036N*    P=0.513N     P=0.353N     P=0.058N     |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.247N     P=0.500N    |P=0.043N*    P=0.500N     P=0.418N     P=0.066N     |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |20/50 (40%)  26/50 (52%)  21/50 (42%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     5.0%         2.3%         2.4%         4.7%        |46.1%        59.9%        45.1%        30.0%        |
|TERMINAL (d)       |     2/27 (7%)    1/29 (3%)    1/29 (3%)    2/26 (8%)   |18/34 (53%)  20/31 (65%)  13/36 (36%)  12/34 (35%)  |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |590          580          566          593          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.493      P=0.475N     P=0.475N     P=0.683     |P=0.014N*    P=0.083      P=0.550N     P=0.091N     |
|POLY 3             |     P=0.520      P=0.470N     P=0.491N     P=0.677N    |P=0.012N*    P=0.136      P=0.547N     P=0.088N     |
|POLY 1.5           |     P=0.523      P=0.481N     P=0.493N     P=0.680N    |P=0.012N*    P=0.133      P=0.572      P=0.090N     |
|POLY 6             |     P=0.513      P=0.458N     P=0.488N     P=0.675N    |P=0.012N*    P=0.143      P=0.482N     P=0.088N     |
|LOGISTIC REGRESSION|     P=0.493      P=0.475N     P=0.475N     P=0.683     |P=0.012N*    P=0.132      P=0.572      P=0.090N     |
|COCH-ARM / FISHERS |     P=0.521      P=0.500N     P=0.500N     P=0.691N    |P=0.017N*    P=0.158      P=0.500      P=0.101N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         7.2%         2.4%        |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    2/29 (7%)    1/26 (4%)   |0/34 (0%)    1/31 (3%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          698          733 (T)     |---          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.531      P=0.486N     P=0.328      P=0.754     |P=0.571N     P=0.482      (e)          (e)          |
|POLY 3             |     P=0.558      P=0.483N     P=0.315      P=0.750N    |P=0.579N     P=0.498      (e)          (e)          |
|POLY 1.5           |     P=0.562      P=0.489N     P=0.313      P=0.752N    |P=0.579N     P=0.497      (e)          (e)          |
|POLY 6             |     P=0.550      P=0.476N     P=0.319      P=0.749N    |P=0.579N     P=0.498      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.554      (e)          P=0.318      P=0.754     |(e)          P=0.482      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.558      P=0.500N     P=0.309      P=0.753N    |P=0.576N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.2%         4.7%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    1/36 (3%)    2/34 (6%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.087      (e)          P=0.511      P=0.238      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.085      (e)          P=0.509      P=0.238      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.085      (e)          P=0.506      P=0.238      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.084      (e)          P=0.512      P=0.237      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.511      P=0.238      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.084      (e)          P=0.500      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         7.2%         2.4%        |0.0%         2.4%         2.2%         4.7%         |
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    2/29 (7%)    1/26 (4%)   |0/34 (0%)    1/31 (3%)    1/36 (3%)    2/34 (6%)    |
|FIRST INCIDENCE    |     733 (T)      ---          698          733 (T)     |---          735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.531      P=0.486N     P=0.328      P=0.754     |P=0.201      P=0.482      P=0.511      P=0.238      |
|POLY 3             |     P=0.558      P=0.483N     P=0.315      P=0.750N    |P=0.196      P=0.498      P=0.509      P=0.238      |
|POLY 1.5           |     P=0.562      P=0.489N     P=0.313      P=0.752N    |P=0.197      P=0.497      P=0.506      P=0.238      |
|POLY 6             |     P=0.550      P=0.476N     P=0.319      P=0.749N    |P=0.195      P=0.498      P=0.512      P=0.237      |
|LOGISTIC REGRESSION|     P=0.554      (e)          P=0.318      P=0.754     |(e)          P=0.482      P=0.511      P=0.238      |
|COCH-ARM / FISHERS |     P=0.558      P=0.500N     P=0.309      P=0.753N    |P=0.194      P=0.500      P=0.500      P=0.247      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.7%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    2/34 (6%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.238      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.238      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.238      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.237      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.238      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.042 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         0.0%         7.2%         2.4%        |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    2/29 (7%)    1/26 (4%)   |0/34 (0%)    1/31 (3%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          698          733 (T)     |---          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.531      P=0.486N     P=0.328      P=0.754     |P=0.571N     P=0.482      (e)          (e)          |
|POLY 3             |     P=0.558      P=0.483N     P=0.315      P=0.750N    |P=0.579N     P=0.498      (e)          (e)          |
|POLY 1.5           |     P=0.562      P=0.489N     P=0.313      P=0.752N    |P=0.579N     P=0.497      (e)          (e)          |
|POLY 6             |     P=0.550      P=0.476N     P=0.319      P=0.749N    |P=0.579N     P=0.498      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.554      (e)          P=0.318      P=0.754     |(e)          P=0.482      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.558      P=0.500N     P=0.309      P=0.753N    |P=0.576N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.3%         2.4%         4.4%         0.0%         |
|TERMINAL (d)       |                                                        |1/34 (3%)    1/31 (3%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      735 (T)      225          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.331N     P=0.741      P=0.521      P=0.500N     |
|POLY 3             |                                                        |P=0.329N     P=0.758      P=0.524      P=0.499N     |
|POLY 1.5           |                                                        |P=0.329N     P=0.757      P=0.517      P=0.499N     |
|POLY 6             |                                                        |P=0.330N     P=0.759      P=0.532      P=0.500N     |
|LOGISTIC REGRESSION|                                                        |P=0.391N     P=0.741      P=0.440      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.338N     P=0.753N     P=0.500      P=0.505N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     36/49 (73%)  33/50 (66%)  31/50 (62%)  30/50 (60%) |30/50 (60%)  27/50 (54%)  29/48 (60%)  25/49 (51%)  |
|POLY-3 ADJUSTED (b)|     79.6%        69.2%        67.6%        64.0%       |64.2%        60.6%        65.7%        56.8%        |
|TERMINAL (d)       |     21/27 (78%)  20/29 (69%)  19/29 (66%)  16/26 (62%) |20/34 (59%)  20/31 (65%)  23/34 (68%)  21/34 (62%)  |
|FIRST INCIDENCE    |     495          526          435          525         |397          551          448          610          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.298N     P=0.193N     P=0.173N     P=0.204N    |P=0.194N     P=0.491N     P=0.466N     P=0.237N     |
|POLY 3             |     P=0.110N     P=0.175N     P=0.135N     P=0.067N    |P=0.288N     P=0.444N     P=0.529      P=0.302N     |
|POLY 1.5           |     P=0.108N     P=0.199N     P=0.128N     P=0.072N    |P=0.249N     P=0.424N     P=0.548      P=0.262N     |
|POLY 6             |     P=0.123N     P=0.160N     P=0.155N     P=0.073N    |P=0.349N     P=0.460N     P=0.507      P=0.362N     |
|LOGISTIC REGRESSION|     P=0.121N     P=0.193N     P=0.132N     P=0.083N    |P=0.199N     P=0.367N     P=0.556N     P=0.204N     |
|COCH-ARM / FISHERS |     P=0.138N     P=0.278N     P=0.157N     P=0.113N    |P=0.261N     P=0.343N     P=0.565      P=0.243N     |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     37/49 (76%)  34/50 (68%)  31/50 (62%)  30/50 (60%) |30/50 (60%)  27/50 (54%)  30/48 (63%)  25/49 (51%)  |
|POLY-3 ADJUSTED (b)|     81.8%        71.2%        67.6%        64.0%       |64.2%        60.6%        67.3%        56.8%        |
|TERMINAL (d)       |     22/27 (82%)  20/29 (69%)  19/29 (66%)  16/26 (62%) |20/34 (59%)  20/31 (65%)  23/34 (68%)  21/34 (62%)  |
|FIRST INCIDENCE    |     495          526          435          525         |397          551          448          610          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.240N     P=0.190N     P=0.132N     P=0.162N    |P=0.194N     P=0.491N     P=0.533N     P=0.237N     |
|POLY 3             |     P=0.065N     P=0.161N     P=0.083N     P=0.038N*   |P=0.286N     P=0.444N     P=0.465      P=0.302N     |
|POLY 1.5           |     P=0.066N     P=0.188N     P=0.081N     P=0.042N*   |P=0.247N     P=0.424N     P=0.475      P=0.262N     |
|POLY 6             |     P=0.074N     P=0.144N     P=0.096N     P=0.040N*   |P=0.348N     P=0.460N     P=0.457      P=0.362N     |
|LOGISTIC REGRESSION|     P=0.076N     P=0.178N     P=0.087N     P=0.051N    |P=0.198N     P=0.367N     P=0.522      P=0.204N     |
|COCH-ARM / FISHERS |     P=0.091N     P=0.272N     P=0.109N     P=0.075N    |P=0.258N     P=0.343N     P=0.482      P=0.243N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.5%         4.5%         4.8%         4.7%        |                                                    |
|TERMINAL (d)       |     1/27 (4%)    2/29 (7%)    2/29 (7%)    2/26 (8%)   |                                                    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.459      P=0.525      P=0.525      P=0.487     |                                                    |
|POLY 3             |     P=0.501      P=0.530      P=0.509      P=0.517     |                                                    |
|POLY 1.5           |     P=0.500      P=0.519      P=0.507      P=0.513     |                                                    |
|POLY 6             |     P=0.497      P=0.542      P=0.512      P=0.519     |                                                    |
|LOGISTIC REGRESSION|     P=0.459      P=0.525      P=0.525      P=0.487     |                                                    |
|COCH-ARM / FISHERS |     P=0.490      P=0.500      P=0.500      P=0.500     |                                                    |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    6/50 (12%)   3/50 (6%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         9.0%         14.5%        7.0%        |2.3%         0.0%         6.7%         0.0%         |
|TERMINAL (d)       |     2/27 (7%)    3/29 (10%)   6/29 (21%)   2/26 (8%)   |0/34 (0%)    0/31 (0%)    3/36 (8%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      576          733 (T)      560         |566          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.547      P=0.375      P=0.152      P=0.493     |P=0.436N     P=0.505N     P=0.328      P=0.491N     |
|POLY 3             |     P=0.577N     P=0.383      P=0.139      P=0.528     |P=0.445N     P=0.505N     P=0.316      P=0.501N     |
|POLY 1.5           |     P=0.579N     P=0.366      P=0.138      P=0.521     |P=0.443N     P=0.504N     P=0.313      P=0.500N     |
|POLY 6             |     P=0.579N     P=0.402      P=0.140      P=0.534     |P=0.448N     P=0.506N     P=0.320      P=0.503N     |
|LOGISTIC REGRESSION|     P=0.589      P=0.376      P=0.152      P=0.519     |P=0.447N     P=0.476N     P=0.306      P=0.514N     |
|COCH-ARM / FISHERS |     P=0.584      P=0.339      P=0.134      P=0.500     |P=0.448N     P=0.500N     P=0.309      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    7/50 (14%)   3/50 (6%)   |3/50 (6%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         9.0%         16.8%        7.0%        |7.0%         0.0%         2.2%         0.0%         |
|TERMINAL (d)       |     0/27 (0%)    2/29 (7%)    6/29 (21%)   1/26 (4%)   |3/34 (9%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     672          686          665          672         |735 (T)      ---          716          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.466      P=0.224      P=0.040 *    P=0.326     |P=0.154N     P=0.137N     P=0.287N     P=0.121N     |
|POLY 3             |     P=0.514      P=0.206      P=0.032 *    P=0.323     |P=0.156N     P=0.120N     P=0.289N     P=0.117N     |
|POLY 1.5           |     P=0.512      P=0.196      P=0.032 *    P=0.319     |P=0.155N     P=0.121N     P=0.295N     P=0.118N     |
|POLY 6             |     P=0.508      P=0.216      P=0.032 *    P=0.324     |P=0.157N     P=0.119N     P=0.282N     P=0.117N     |
|LOGISTIC REGRESSION|     P=0.494      P=0.205      P=0.035 *    P=0.320     |P=0.157N     (e)          P=0.279N     (e)          |
|COCH-ARM / FISHERS |     P=0.493      P=0.181      P=0.030 *    P=0.309     |P=0.160N     P=0.121N     P=0.309N     P=0.121N     |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    8/50 (16%)   4/50 (8%)   |3/50 (6%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.9%         9.0%         19.2%        9.3%        |7.0%         0.0%         2.2%         2.3%         |
|TERMINAL (d)       |     1/27 (4%)    2/29 (7%)    7/29 (24%)   1/26 (4%)   |3/34 (9%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     672          686          665          671         |735 (T)      ---          716          726          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.401      P=0.395      P=0.058      P=0.362     |P=0.427N     P=0.137N     P=0.287N     P=0.304N     |
|POLY 3             |     P=0.449      P=0.378      P=0.047 *    P=0.362     |P=0.438N     P=0.120N     P=0.289N     P=0.303N     |
|POLY 1.5           |     P=0.448      P=0.363      P=0.048 *    P=0.356     |P=0.437N     P=0.121N     P=0.295N     P=0.303N     |
|POLY 6             |     P=0.446      P=0.394      P=0.047 *    P=0.366     |P=0.440N     P=0.119N     P=0.282N     P=0.303N     |
|LOGISTIC REGRESSION|     P=0.430      P=0.385      P=0.051      P=0.357     |P=0.441N     (e)          P=0.279N     P=0.302N     |
|COCH-ARM / FISHERS |     P=0.429      P=0.339      P=0.046 *    P=0.339     |P=0.442N     P=0.121N     P=0.309N     P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         4.5%         2.4%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    1/29 (3%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      686          733 (T)      671         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.549N     P=0.543      P=0.746N     P=0.752N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.524N     P=0.532      P=0.755N     P=0.749N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.526N     P=0.520      P=0.756N     P=0.752N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.524N     P=0.546      P=0.754N     P=0.747N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.532N     P=0.535      P=0.746N     P=0.753N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.535N     P=0.500      P=0.753N     P=0.753N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         4.5%         2.4%         2.3%        |0.0%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    1/29 (3%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      686          733 (T)      671         |---          ---          ---          726          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.549N     P=0.543      P=0.746N     P=0.752N    |P=0.224      (e)          (e)          P=0.506      |
|POLY 3             |     P=0.524N     P=0.532      P=0.755N     P=0.749N    |P=0.216      (e)          (e)          P=0.501      |
|POLY 1.5           |     P=0.526N     P=0.520      P=0.756N     P=0.752N    |P=0.216      (e)          (e)          P=0.501      |
|POLY 6             |     P=0.524N     P=0.546      P=0.754N     P=0.747N    |P=0.215      (e)          (e)          P=0.501      |
|LOGISTIC REGRESSION|     P=0.532N     P=0.535      P=0.746N     P=0.753N    |P=0.212      (e)          (e)          P=0.500      |
|COCH-ARM / FISHERS |     P=0.535N     P=0.500      P=0.753N     P=0.753N    |P=0.214      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    5/50 (10%)   2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         9.0%         12.1%        4.7%        |0.0%         0.0%         4.5%         0.0%         |
|TERMINAL (d)       |     2/27 (7%)    3/29 (10%)   5/29 (17%)   2/26 (8%)   |0/34 (0%)    0/31 (0%)    2/36 (6%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      576          733 (T)      733 (T)     |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.462N     P=0.375      P=0.242      P=0.683     |P=0.690N     (e)          P=0.251      (e)          |
|POLY 3             |     P=0.412N     P=0.383      P=0.225      P=0.677N    |P=0.695N     (e)          P=0.247      (e)          |
|POLY 1.5           |     P=0.412N     P=0.366      P=0.224      P=0.680N    |P=0.694N     (e)          P=0.243      (e)          |
|POLY 6             |     P=0.418N     P=0.402      P=0.227      P=0.675N    |P=0.696N     (e)          P=0.251      (e)          |
|LOGISTIC REGRESSION|     P=0.427N     P=0.376      P=0.242      P=0.683     |(e)          (e)          P=0.251      (e)          |
|COCH-ARM / FISHERS |     P=0.425N     P=0.339      P=0.218      P=0.691N    |P=0.697N     (e)          P=0.247      (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Lipoma                                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.3%         4.8%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/27 (4%)    1/29 (3%)    1/29 (3%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      698          547         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.643      P=0.746N     P=0.520      P=0.760N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.631N     P=0.741N     P=0.510      P=0.747N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.631N     P=0.748N     P=0.508      P=0.750N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.632N     P=0.734N     P=0.514      P=0.744N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.638N     P=0.746N     P=0.514      P=0.744     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.640N     P=0.753N     P=0.500      P=0.753N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    5/50 (10%)   3/50 (6%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         9.0%         12.1%        7.0%        |2.3%         0.0%         4.5%         0.0%         |
|TERMINAL (d)       |     2/27 (7%)    3/29 (10%)   5/29 (17%)   2/26 (8%)   |0/34 (0%)    0/31 (0%)    2/36 (6%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      576          733 (T)      560         |566          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.544      P=0.375      P=0.242      P=0.493     |P=0.445N     P=0.505N     P=0.521      P=0.491N     |
|POLY 3             |     P=0.587N     P=0.383      P=0.225      P=0.528     |P=0.452N     P=0.505N     P=0.511      P=0.501N     |
|POLY 1.5           |     P=0.590N     P=0.366      P=0.224      P=0.521     |P=0.451N     P=0.504N     P=0.507      P=0.500N     |
|POLY 6             |     P=0.589N     P=0.402      P=0.227      P=0.534     |P=0.455N     P=0.506N     P=0.515      P=0.503N     |
|LOGISTIC REGRESSION|     P=0.585      P=0.376      P=0.242      P=0.519     |P=0.456N     P=0.476N     P=0.495      P=0.514N     |
|COCH-ARM / FISHERS |     P=0.580      P=0.339      P=0.218      P=0.500     |P=0.455N     P=0.500N     P=0.500      P=0.500N     |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    5/50 (10%)   3/50 (6%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.0%         9.0%         12.1%        7.0%        |0.0%         0.0%         4.5%         0.0%         |
|TERMINAL (d)       |     2/27 (7%)    3/29 (10%)   5/29 (17%)   2/26 (8%)   |0/34 (0%)    0/31 (0%)    2/36 (6%)    0/34 (0%)    |
|FIRST INCIDENCE    |     733 (T)      576          733 (T)      560         |---          ---          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.544      P=0.375      P=0.242      P=0.493     |P=0.690N     (e)          P=0.251      (e)          |
|POLY 3             |     P=0.587N     P=0.383      P=0.225      P=0.528     |P=0.695N     (e)          P=0.247      (e)          |
|POLY 1.5           |     P=0.590N     P=0.366      P=0.224      P=0.521     |P=0.694N     (e)          P=0.243      (e)          |
|POLY 6             |     P=0.589N     P=0.402      P=0.227      P=0.534     |P=0.696N     (e)          P=0.251      (e)          |
|LOGISTIC REGRESSION|     P=0.585      P=0.376      P=0.242      P=0.519     |(e)          (e)          P=0.251      (e)          |
|COCH-ARM / FISHERS |     P=0.580      P=0.339      P=0.218      P=0.500     |P=0.697N     (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     40/50 (80%)  35/50 (70%)  41/50 (82%)  33/50 (66%) |                                                    |
|POLY-3 ADJUSTED (b)|     86.1%        76.4%        91.3%        73.9%       |                                                    |
|TERMINAL (d)       |     24/27 (89%)  26/29 (90%)  29/29 (100%) 23/26 (89%) |                                                    |
|FIRST INCIDENCE    |     408          586          552          532         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.272N     P=0.091N     P=0.474N     P=0.154N    |                                                    |
|POLY 3             |     P=0.121N     P=0.157N     P=0.301      P=0.092N    |                                                    |
|POLY 1.5           |     P=0.099N     P=0.152N     P=0.405      P=0.075N    |                                                    |
|POLY 6             |     P=0.190N     P=0.177N     P=0.206      P=0.146N    |                                                    |
|LOGISTIC REGRESSION|     P=0.063N     P=0.056N     P=0.591      P=0.030N*   |                                                    |
|COCH-ARM / FISHERS |     P=0.114N     P=0.178N     P=0.500      P=0.088N    |                                                    |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   8/49 (16%)   4/48 (8%)    9/48 (19%)  |6/47 (13%)   6/47 (13%)   6/50 (12%)   2/47 (4%)    |
|POLY-3 ADJUSTED (b)|     12.6%        18.3%        9.9%         21.5%       |14.6%        15.0%        13.3%        4.9%         |
|TERMINAL (d)       |     4/27 (15%)   6/28 (21%)   4/29 (14%)   6/26 (23%)  |6/34 (18%)   4/31 (13%)   3/36 (8%)    2/33 (6%)    |
|FIRST INCIDENCE    |     697          635          733 (T)      525         |735 (T)      686          672          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.184      P=0.319      P=0.460N     P=0.192     |P=0.089N     P=0.569      P=0.568N     P=0.141N     |
|POLY 3             |     P=0.219      P=0.336      P=0.489N     P=0.218     |P=0.083N     P=0.602      P=0.556N     P=0.132N     |
|POLY 1.5           |     P=0.215      P=0.314      P=0.496N     P=0.208     |P=0.081N     P=0.601      P=0.564N     P=0.130N     |
|POLY 6             |     P=0.220      P=0.361      P=0.483N     P=0.227     |P=0.086N     P=0.607      P=0.541N     P=0.134N     |
|LOGISTIC REGRESSION|     P=0.201      P=0.347      P=0.472N     P=0.206     |P=0.084N     P=0.599      P=0.563N     P=0.141N     |
|COCH-ARM / FISHERS |     P=0.198      P=0.276      P=0.513N     P=0.182     |P=0.087N     P=0.621N     P=0.576N     P=0.134N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    4/49 (8%)    3/48 (6%)    1/48 (2%)   |3/47 (6%)    2/47 (4%)    2/50 (4%)    1/47 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         9.3%         7.4%         2.5%        |7.3%         5.0%         4.5%         2.4%         |
|TERMINAL (d)       |     0/27 (0%)    3/28 (11%)   3/29 (10%)   1/26 (4%)   |3/34 (9%)    2/31 (7%)    2/36 (6%)    1/33 (3%)    |
|FIRST INCIDENCE    |     672          702          733 (T)      733 (T)     |735 (T)      735 (T)      735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.353N     P=0.209      P=0.323      P=0.755N    |P=0.264N     P=0.542N     P=0.474N     P=0.315N     |
|POLY 3             |     P=0.326N     P=0.202      P=0.310      P=0.756N    |P=0.263N     P=0.516N     P=0.465N     P=0.305N     |
|POLY 1.5           |     P=0.328N     P=0.194      P=0.307      P=0.757N    |P=0.261N     P=0.515N     P=0.467N     P=0.303N     |
|POLY 6             |     P=0.329N     P=0.210      P=0.312      P=0.757N    |P=0.267N     P=0.516N     P=0.461N     P=0.309N     |
|LOGISTIC REGRESSION|     P=0.342N     P=0.210      P=0.317      P=0.758N    |P=0.264N     P=0.542N     P=0.474N     P=0.315N     |
|COCH-ARM / FISHERS |     P=0.342N     P=0.181      P=0.301      P=0.747     |P=0.268N     P=0.500N     P=0.470N     P=0.308N     |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/49 (12%)   11/49 (22%)  7/48 (15%)   10/48 (21%) |8/47 (17%)   8/47 (17%)   8/50 (16%)   3/47 (6%)    |
|POLY-3 ADJUSTED (b)|     15.0%        25.1%        17.3%        23.9%       |19.4%        20.0%        17.7%        7.3%         |
|TERMINAL (d)       |     4/27 (15%)   8/28 (29%)   7/29 (24%)   7/26 (27%)  |8/34 (24%)   6/31 (19%)   5/36 (14%)   3/33 (9%)    |
|FIRST INCIDENCE    |     672          635          733 (T)      525         |735 (T)      686          672          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.288      P=0.187      P=0.545      P=0.208     |P=0.062N     P=0.542      P=0.548N     P=0.105N     |
|POLY 3             |     P=0.343      P=0.188      P=0.509      P=0.230     |P=0.057N     P=0.585      P=0.530N     P=0.096N     |
|POLY 1.5           |     P=0.337      P=0.171      P=0.503      P=0.221     |P=0.056N     P=0.584      P=0.540N     P=0.095N     |
|POLY 6             |     P=0.343      P=0.206      P=0.512      P=0.236     |P=0.060N     P=0.591      P=0.513N     P=0.098N     |
|LOGISTIC REGRESSION|     P=0.312      P=0.199      P=0.534      P=0.221     |P=0.059N     P=0.582      P=0.535N     P=0.105N     |
|COCH-ARM / FISHERS |     P=0.309      P=0.143      P=0.484      P=0.194     |P=0.062N     P=0.608N     P=0.554N     P=0.099N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |10/50 (20%)  4/50 (8%)    10/50 (20%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|                                                        |23.5%        9.5%         22.5%        22.6%        |
|TERMINAL (d)       |                                                        |10/34 (29%)  3/31 (10%)   10/36 (28%)  7/34 (21%)   |
|FIRST INCIDENCE    |                                                        |735 (T)      728          735 (T)      535          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.305      P=0.099N     P=0.545N     P=0.597N     |
|POLY 3             |                                                        |P=0.315      P=0.073N     P=0.557N     P=0.563N     |
|POLY 1.5           |                                                        |P=0.305      P=0.075N     P=0.572N     P=0.576N     |
|POLY 6             |                                                        |P=0.327      P=0.070N     P=0.539N     P=0.547N     |
|LOGISTIC REGRESSION|                                                        |P=0.278      P=0.083N     P=0.545N     P=0.595N     |
|COCH-ARM / FISHERS |                                                        |P=0.278      P=0.074N     P=0.598N     P=0.598N     |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 22
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |10/50 (20%)  5/50 (10%)   10/50 (20%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|                                                        |23.5%        11.8%        22.5%        22.6%        |
|TERMINAL (d)       |                                                        |10/34 (29%)  3/31 (10%)   10/36 (28%)  7/34 (21%)   |
|FIRST INCIDENCE    |                                                        |735 (T)      695          735 (T)      535          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.352      P=0.170N     P=0.545N     P=0.597N     |
|POLY 3             |                                                        |P=0.362      P=0.129N     P=0.557N     P=0.563N     |
|POLY 1.5           |                                                        |P=0.352      P=0.134N     P=0.572N     P=0.576N     |
|POLY 6             |                                                        |P=0.373      P=0.124N     P=0.539N     P=0.547N     |
|LOGISTIC REGRESSION|                                                        |P=0.325      P=0.130N     P=0.545N     P=0.595N     |
|COCH-ARM / FISHERS |                                                        |P=0.324      P=0.131N     P=0.598N     P=0.598N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    1/34 (3%)    |
|FIRST INCIDENCE    |     ---          285          ---          ---         |---          ---          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.256N     P=0.154      (e)          (e)         |P=0.218      (e)          (e)          P=0.500      |
|POLY 3             |     P=0.227N     P=0.141      (e)          (e)         |P=0.216      (e)          (e)          P=0.501      |
|POLY 1.5           |     P=0.234N     P=0.133      (e)          (e)         |P=0.216      (e)          (e)          P=0.501      |
|POLY 6             |     P=0.220N     P=0.150      (e)          (e)         |P=0.215      (e)          (e)          P=0.500      |
|LOGISTIC REGRESSION|     P=0.337N     P=0.055      (e)          (e)         |(e)          (e)          (e)          P=0.500      |
|COCH-ARM / FISHERS |     P=0.255N     P=0.121      (e)          (e)         |P=0.214      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 23
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     16/50 (32%)  23/50 (46%)  29/50 (58%)  25/50 (50%) |14/50 (28%)  21/50 (42%)  14/50 (28%)  24/50 (48%)  |
|POLY-3 ADJUSTED (b)|     37.0%        49.6%        61.6%        55.8%       |31.6%        46.3%        30.7%        51.0%        |
|TERMINAL (d)       |     9/27 (33%)   14/29 (48%)  14/29 (48%)  14/26 (54%) |10/34 (29%)  11/31 (36%)  9/36 (25%)   14/34 (41%)  |
|FIRST INCIDENCE    |     135          586          403          532         |504          428          595          411          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.118      P=0.228      P=0.035 *    P=0.080     |P=0.090      P=0.092      P=0.513N     P=0.051      |
|POLY 3             |     P=0.103      P=0.157      P=0.013 *    P=0.053     |P=0.072      P=0.110      P=0.555N     P=0.044 *    |
|POLY 1.5           |     P=0.109      P=0.131      P=0.009 **   P=0.052     |P=0.064      P=0.102      P=0.567N     P=0.038 *    |
|POLY 6             |     P=0.094      P=0.196      P=0.024 *    P=0.054     |P=0.083      P=0.121      P=0.536N     P=0.054      |
|LOGISTIC REGRESSION|     P=0.120      P=0.117      P=0.007 **   P=0.061     |P=0.055      P=0.099      P=0.561N     P=0.032 *    |
|COCH-ARM / FISHERS |     P=0.114      P=0.109      P=0.008 **   P=0.052     |P=0.054      P=0.104      P=0.588N     P=0.032 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         2.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     714          ---          656          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.272N     P=0.218N     P=0.481N     P=0.240N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.282N     P=0.218N     P=0.489N     P=0.226N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.277N     P=0.225N     P=0.492N     P=0.229N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.288N     P=0.212N     P=0.485N     P=0.225N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.269N     P=0.208N     P=0.491N     P=0.226N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.271N     P=0.247N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 24
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Malignant                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.9%         0.0%         2.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/27 (4%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     714          ---          656          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.272N     P=0.218N     P=0.481N     P=0.240N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.282N     P=0.218N     P=0.489N     P=0.226N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.277N     P=0.225N     P=0.492N     P=0.229N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.288N     P=0.212N     P=0.485N     P=0.225N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.269N     P=0.208N     P=0.491N     P=0.226N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.271N     P=0.247N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.2%         0.0%         2.4%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     408          ---          435          671         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.434N     P=0.109N     P=0.296N     P=0.284N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.453N     P=0.110N     P=0.302N     P=0.298N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.448N     P=0.113N     P=0.301N     P=0.298N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.460N     P=0.107N     P=0.303N     P=0.301N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.573N     P=0.169N     P=0.398N     P=0.407N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.442N     P=0.121N     P=0.309N     P=0.309N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 25
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.2%         0.0%         4.7%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/27 (0%)    0/29 (0%)    0/29 (0%)    0/26 (0%)   |0/34 (0%)    0/31 (0%)    0/36 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     408          ---          435          671         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.428N     P=0.109N     P=0.487N     P=0.284N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.447N     P=0.110N     P=0.494N     P=0.298N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.441N     P=0.113N     P=0.494N     P=0.298N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.455N     P=0.107N     P=0.494N     P=0.301N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.550N     P=0.169N     P=0.596N     P=0.407N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.437N     P=0.121N     P=0.500N     P=0.309N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     47/50 (94%)  48/50 (96%)  48/50 (96%)  48/50 (96%) |44/50 (88%)  39/50 (78%)  44/50 (88%)  40/50 (80%)  |
|POLY-3 ADJUSTED (b)|     97.0%        97.9%        99.1%        98.0%       |92.4%        86.7%        90.6%        86.5%        |
|TERMINAL (d)       |     26/27 (96%)  29/29 (100%) 29/29 (100%) 26/26 (100%)|32/34 (94%)  28/31 (90%)  32/36 (89%)  31/34 (91%)  |
|FIRST INCIDENCE    |     408          526          435          525         |397          551          436          535          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.365      P=0.341N     P=0.462N     P=0.521     |P=0.290N     P=0.411N     P=0.381N     P=0.280N     |
|POLY 3             |     P=0.603      P=0.654      P=0.494      P=0.657     |P=0.313N     P=0.275N     P=0.521N     P=0.261N     |
|POLY 1.5           |     P=0.633      P=0.620      P=0.550      P=0.659     |P=0.285N     P=0.234N     P=0.556N     P=0.225N     |
|POLY 6             |     P=0.483      P=0.702      P=0.465      P=0.607     |P=0.354N     P=0.314N     P=0.468N     P=0.306N     |
|LOGISTIC REGRESSION|     P=0.501N     P=0.685N     P=0.652      P=0.628N    |P=0.243N     P=0.151N     P=0.548N     P=0.157N     |
|COCH-ARM / FISHERS |     P=0.491      P=0.500      P=0.500      P=0.500     |P=0.323N     P=0.143N     P=0.620N     P=0.207N     |
|=================================================================================================================================|
       Date:  10/28/99                           EXPERIMENT: 88124 TEST: 03                                            Page 26
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     26/50 (52%)  37/50 (74%)  42/50 (84%)  37/50 (74%) |25/50 (50%)  30/50 (60%)  24/50 (48%)  32/50 (64%)  |
|POLY-3 ADJUSTED (b)|     56.0%        76.6%        85.6%        78.5%       |54.0%        64.6%        51.1%        68.0%        |
|TERMINAL (d)       |     11/27 (41%)  19/29 (66%)  23/29 (79%)  19/26 (73%) |17/34 (50%)  16/31 (52%)  17/36 (47%)  21/34 (62%)  |
|FIRST INCIDENCE    |     135          285          403          532         |476          428          225          411          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.128      P=0.161      P=0.028 *    P=0.079     |P=0.230      P=0.183      P=0.403N     P=0.160      |
|POLY 3             |     P=0.059      P=0.024 *    P<0.001 **   P=0.014 *   |P=0.153      P=0.203      P=0.467N     P=0.117      |
|POLY 1.5           |     P=0.065      P=0.020 *    P<0.001 **   P=0.015 *   |P=0.155      P=0.192      P=0.468N     P=0.115      |
|POLY 6             |     P=0.053      P=0.031 *    P<0.001 **   P=0.013 *   |P=0.153      P=0.220      P=0.465N     P=0.121      |
|LOGISTIC REGRESSION|     P=0.080      P=0.014 *    P<0.001 **   P=0.018 *   |P=0.151      P=0.197      P=0.492N     P=0.115      |
|COCH-ARM / FISHERS |     P=0.082      P=0.019 *    P<0.001 **   P=0.019 *   |P=0.146      P=0.211      P=0.500N     P=0.113      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      0.03         0.1MG/M3     0.3MG/M3    |CONTROL      0.03         0.1MG/M3     0.3MG/M3     |
|                   |                  MG/M3         STOP         STOP       |             MG/M3         STOP         STOP        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     49/50 (98%)  50/50 (100%) 50/50 (100%) 50/50 (100%)|49/50 (98%)  47/50 (94%)  48/50 (96%)  46/50 (92%)  |
|POLY-3 ADJUSTED (b)|     99.1%        100.0%       100.0%       100.0%      |100.0%       97.9%        96.0%        94.8%        |
|TERMINAL (d)       |     27/27 (100%) 29/29 (100%) 29/29 (100%) 26/26 (100%)|34/34 (100%) 30/31 (97%)  34/36 (94%)  32/34 (94%)  |
|FIRST INCIDENCE    |     135          285          403          525         |397          428          225          411          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.371      P=0.339N     P=0.460N     P=0.523     |P=0.286N     P=0.498      P=0.303N     P=0.364N     |
|POLY 3             |     P=0.864      P=0.910      P=0.910      P=0.910     |P=0.133N     P=0.496N     P=0.243N     P=0.150N     |
|POLY 1.5           |     P=0.654      P=0.702      P=0.702      P=0.702     |P=0.105N     P=0.494N     P=0.258N     P=0.127N     |
|POLY 6             |     P=1.000      P=1.000      P=1.000      P=1.000     |P=0.173N     P=0.496N     P=0.242N     P=0.184N     |
|LOGISTIC REGRESSION|     P=0.540      P=0.571      P=0.553      P=0.594     |P=0.102N     P=0.462N     P=0.433N     P=0.119N     |
|COCH-ARM / FISHERS |     P=0.474      P=0.500      P=0.500      P=0.500     |P=0.191N     P=0.309N     P=0.500N     P=0.181N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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