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TDMS Study 88124-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/22/00       
EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 09:35:07       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124       
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                              FINAL#2,                                                              
                                                                                                                                    

               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    CONTROL                                                                       
                                       INCLUDE 002    CONTROL                                                                       
                                       INCLUDE 005    0.1MG/M3 STOP                                                                 
                                       INCLUDE 006    0.1MG/M3 STOP                                                                 
                                       INCLUDE 007    0.3MG/M3 STOP                                                                 
                                       INCLUDE 008    0.3MG/M3 STOP                                                                 
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/22/00     
EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 09:35:07     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124     
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 INDIUM PHOSPHIDE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hypertrophy
Heart                                  Cardiomyopathy
Heart: Artery                          Inflammation
Heart: Pericardium                     Inflammation
Intestine Small, Ileum: Peyer's Patch  Hyperplasia
Kidney: Artery                         Inflammation
Larynx                                 Inflammation
Liver                                  Eosinophilic Focus
Lung                                   Foreign Body
                                       Inflammation Chronic
Lung: Alveolar Epithelium              Hyperplasia
Lung: Alveolus                         Proteinosis
Lung: Serosa                           Fibrosis
Lymph Node, Bronchial                  Foreign Body
                                       Hyperplasia
Lymph Node, Mediastinal                Foreign Body
                                       Hyperplasia
Preputial Gland                        Inflammation
Spleen                                 Hematopoietic Cell Proliferation
                                       Hyperplasia Lymphoid
Stomach, Forestomach: Epithelium       Hyperplasia
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Hypertrophy
Bone                                   Fibrous Osteodystrophy
Heart                                  Cardiomyopathy
Heart: Artery                          Inflammation
Heart: Epicardium                      Inflammation
Heart: Pericardium                     Inflammation
Kidney                                 Nephropathy
Kidney: Artery                         Inflammation
Larynx: Squamous Epithelium            Hyperplasia
Liver                                  Eosinophilic Focus
Lung                                   Foreign Body
                                       Inflammation Chronic
Lung: Alveolus                         Infiltration Cellular Histiocyte
                                       Proteinosis
Lung: Bronchiole, Bronchus             Degeneration Hyaline
Lung: Serosa                           Fibrosis
Lymph Node, Bronchial                  Foreign Body
                                       Hyperplasia
Lymph Node, Mediastinal                Foreign Body
                                       Hyperplasia
Nose: Olfactory Epithelium             Degeneration Hyaline
Nose: Respiratory Epithelium           Degeneration Hyaline
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     INDIUM PHOSPHIDE                                   DATE: 02/22/00     
EXPERIMENT: 88124 TEST: 04                                                                                     TIME: 09:35:07     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25335                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C88124     
PATHOLOGIST: MILLER, R.                                                                                        CAS: 22398-80-7    

Pituitary Gland: Pars Distalis         Hyperplasia
Spleen                                 Hematopoietic Cell Proliferation
                                       Hyperplasia Lymphoid
Thyroid Gland                          Inflammation
Tooth                                  Malformation
Uterus                                 Angiectasis
                                       Hyperplasia Cystic
===============================================================
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Amyloid Deposition                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/48 (0%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.3%             0.0%             5.1%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  1/42 (2%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  678              ---              594             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.429          P=0.274N         P=0.554         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.507          P=0.243N         P=0.623         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.525          P=0.239N         P=0.653         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.486          P=0.252N         P=0.584         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.644          P=0.238N         P=0.647N        |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.554          P=0.247N         P=0.691N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        2/48 (4%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        2.2%             4.9%             2.4%          |  0.0%             0.0%             2.6%            |
|TERMINAL (d)       |        1/37 (3%)        2/29 (7%)        1/27 (4%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          733 (T)          733 (T)       |  ---              ---              658             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.618          P=0.415          P=0.690       |  P=0.228          (e)              P=0.421         |
|POLY 3             |        P=0.638N         P=0.459          P=0.736       |  P=0.261          (e)              P=0.460         |
|POLY 1.5           |        P=0.624N         P=0.470          P=0.746       |  P=0.275          (e)              P=0.476         |
|POLY 6             |        P=0.639          P=0.446          P=0.723       |  P=0.245          (e)              P=0.439         |
|LOGISTIC REGRESSION|        P=0.618          P=0.415          P=0.690       |  P=0.327          (e)              P=0.527         |
|COCH-ARM / FISHERS |        P=0.603N         P=0.485          P=0.753N      |  P=0.296          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        30/50 (60%)      23/48 (48%)      19/50 (38%)   |  9/50 (18%)       3/50 (6%)        10/50 (20%)     |
|POLY-3 ADJUSTED (b)|        63.3%            55.5%            45.2%         |  19.2%            6.5%             25.7%           |
|TERMINAL (d)       |        25/37 (68%)      20/29 (69%)      14/27 (52%)   |  9/42 (21%)       2/33 (6%)        7/21 (33%)      |
|FIRST INCIDENCE    |        559              672              664           |  735 (T)          685              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.259N         P=0.527N         P=0.289N      |  P=0.030 *        P=0.129N         P=0.055         |
|POLY 3             |        P=0.050N         P=0.290N         P=0.059N      |  P=0.204          P=0.063N         P=0.325         |
|POLY 1.5           |        P=0.035N*        P=0.228N         P=0.038N*     |  P=0.243          P=0.060N         P=0.397         |
|POLY 6             |        P=0.080N         P=0.386N         P=0.098N      |  P=0.162          P=0.070N         P=0.239         |
|LOGISTIC REGRESSION|        P=0.109N         P=0.376N         P=0.111N      |  P=0.136          P=0.088N         P=0.251         |
|COCH-ARM / FISHERS |        P=0.022N*        P=0.159N         P=0.022N*     |  P=0.311          P=0.061N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        1/48 (2%)        6/49 (12%)    |  4/49 (8%)        2/50 (4%)        3/49 (6%)       |
|POLY-3 ADJUSTED (b)|        6.4%             2.4%             14.5%         |  8.7%             4.3%             7.9%            |
|TERMINAL (d)       |        2/37 (5%)        0/29 (0%)        4/27 (15%)    |  4/41 (10%)       1/33 (3%)        2/21 (10%)      |
|FIRST INCIDENCE    |        559              672              562           |  735 (T)          589              705             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.067          P=0.374N         P=0.145       |  P=0.429          P=0.422N         P=0.470         |
|POLY 3             |        P=0.089          P=0.351N         P=0.186       |  P=0.580N         P=0.332N         P=0.603N        |
|POLY 1.5           |        P=0.096          P=0.338N         P=0.204       |  P=0.550N         P=0.328N         P=0.561N        |
|POLY 6             |        P=0.081          P=0.366N         P=0.166       |  P=0.583          P=0.345N         P=0.646         |
|LOGISTIC REGRESSION|        P=0.123          P=0.258N         P=0.272       |  P=0.614          P=0.328N         P=0.571         |
|COCH-ARM / FISHERS |        P=0.108          P=0.324N         P=0.233       |  P=0.502N         P=0.329N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/49 (4%)        2/50 (4%)        2/50 (4%)     |  11/50 (22%)      14/50 (28%)      16/50 (32%)     |
|POLY-3 ADJUSTED (b)|        4.4%             4.7%             4.8%          |  23.5%            30.4%            40.1%           |
|TERMINAL (d)       |        2/36 (6%)        1/29 (3%)        2/27 (7%)     |  11/42 (26%)      13/33 (39%)      9/21 (43%)      |
|FIRST INCIDENCE    |        733 (T)          678              733 (T)       |  735 (T)          672              510             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.528          P=0.617          P=0.588       |  P<0.001 **       P=0.120          P=0.003 **      |
|POLY 3             |        P=0.594          P=0.671          P=0.663       |  P=0.066          P=0.303          P=0.074         |
|POLY 1.5           |        P=0.611          P=0.683          P=0.678       |  P=0.101          P=0.318          P=0.111         |
|POLY 6             |        P=0.571          P=0.655          P=0.642       |  P=0.036 *        P=0.271          P=0.041 *       |
|LOGISTIC REGRESSION|        P=0.565          P=0.654          P=0.588       |  P=0.026 *        P=0.177          P=0.048 *       |
|COCH-ARM / FISHERS |        P=0.624N         P=0.684N         P=0.684N      |  P=0.176          P=0.322          P=0.184         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/49 (0%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.3%             2.2%             0.0%            |
|TERMINAL (d)       |        0/36 (0%)        0/29 (0%)        0/27 (0%)     |  2/42 (5%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  735 (T)          735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.305N         P=0.584N         P=0.401N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.207N         P=0.508N         P=0.287N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.194N         P=0.502N         P=0.265N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.223N         P=0.520N         P=0.316N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.305N         P=0.584N         (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.175N         P=0.500N         P=0.247N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/49 (10%)       6/50 (12%)       4/50 (8%)     |  6/50 (12%)       5/50 (10%)       7/50 (14%)      |
|POLY-3 ADJUSTED (b)|        11.1%            13.9%            9.5%          |  12.8%            10.9%            17.7%           |
|TERMINAL (d)       |        4/36 (11%)       3/29 (10%)       2/27 (7%)     |  5/42 (12%)       4/33 (12%)       4/21 (19%)      |
|FIRST INCIDENCE    |        726              475              608           |  678              681              493             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.570N         P=0.370          P=0.613       |  P=0.098          P=0.608          P=0.144         |
|POLY 3             |        P=0.461N         P=0.468          P=0.544N      |  P=0.301          P=0.515N         P=0.369         |
|POLY 1.5           |        P=0.437N         P=0.487          P=0.522N      |  P=0.347          P=0.504N         P=0.423         |
|POLY 6             |        P=0.488N         P=0.443          P=0.570N      |  P=0.247          P=0.539N         P=0.302         |
|LOGISTIC REGRESSION|        P=0.425N         P=0.491          P=0.555N      |  P=0.372          P=0.531N         P=0.468         |
|COCH-ARM / FISHERS |        P=0.402N         P=0.514          P=0.487N      |  P=0.420          P=0.500N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain: Meninges                                                                                                                  |
|     Infiltration Cellular Mononuclear Cell                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |  2/50 (4%)        2/50 (4%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             0.0%          |  4.3%             4.3%             5.1%            |
|TERMINAL (d)       |        0/37 (0%)        2/29 (7%)        0/27 (0%)     |  2/42 (5%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  735 (T)          664              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.643N         P=0.186          (e)           |  P=0.445          P=0.625          P=0.535         |
|POLY 3             |        P=0.615N         P=0.218          (e)           |  P=0.551          P=0.688          P=0.627         |
|POLY 1.5           |        P=0.599N         P=0.226          (e)           |  P=0.583          P=0.693          P=0.656         |
|POLY 6             |        P=0.635N         P=0.207          (e)           |  P=0.508          P=0.678          P=0.589         |
|LOGISTIC REGRESSION|        (e)              P=0.186          (e)           |  P=0.528N         P=0.693          P=0.616N        |
|COCH-ARM / FISHERS |        P=0.575N         P=0.247          (e)           |  P=0.631N         P=0.691N         P=0.691N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Granuloma Sperm                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        2/50 (4%)     |                                                    |
|POLY-3 ADJUSTED (b)|        4.3%             0.0%             4.7%          |                                                    |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |                                                    |
|FIRST INCIDENCE    |        662              ---              370           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.492          P=0.288N         P=0.618       |                                                    |
|POLY 3             |        P=0.537          P=0.259N         P=0.660       |                                                    |
|POLY 1.5           |        P=0.545          P=0.250N         P=0.675       |                                                    |
|POLY 6             |        P=0.525          P=0.272N         P=0.639       |                                                    |
|LOGISTIC REGRESSION|        P=0.637N         P=0.227N         P=0.504N      |                                                    |
|COCH-ARM / FISHERS |        P=0.554          P=0.247N         P=0.691N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        1/50 (2%)        2/50 (4%)     |                                                    |
|POLY-3 ADJUSTED (b)|        2.2%             2.4%             4.8%          |                                                    |
|TERMINAL (d)       |        1/37 (3%)        0/29 (0%)        1/27 (4%)     |                                                    |
|FIRST INCIDENCE    |        733 (T)          682              533           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.331          P=0.701          P=0.420       |                                                    |
|POLY 3             |        P=0.364          P=0.741          P=0.467       |                                                    |
|POLY 1.5           |        P=0.376          P=0.749          P=0.481       |                                                    |
|POLY 6             |        P=0.349          P=0.731          P=0.451       |                                                    |
|LOGISTIC REGRESSION|        P=0.431          P=0.752          P=0.570       |                                                    |
|COCH-ARM / FISHERS |        P=0.393          P=0.753N         P=0.500       |                                                    |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/0 (0%)         2/3 (67%)        0/1 (0%)      |  0/0 (0%)         1/1 (100%)       0/0 (0%)        |
|POLY-3 ADJUSTED (b)|        0.0%             66.7%            0.0%          |  0.0%             100.0%           0.0%            |
|TERMINAL (d)       |        0/0 (0%)         0/1 (0%)         0/1 (0%)      |  0/0 (0%)         1/1 (100%)       0/0 (0%)        |
|FIRST INCIDENCE    |        ---              669              ---           |  ---              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.630N         P=0.191          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 6             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.500N         P=1.000          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Gallbladder                                                                                                                      |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/43 (0%)        0/41 (0%)        2/38 (5%)     |  0/46 (0%)        0/48 (0%)        0/43 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             6.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/28 (0%)        0/24 (0%)     |  0/42 (0%)        0/32 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              664           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.072          (e)              P=0.189       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.071          (e)              P=0.194       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.073          (e)              P=0.201       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.067          (e)              P=0.185       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.082          (e)              P=0.233       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.078          (e)              P=0.217       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Gallbladder                                                                                                                      |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/43 (0%)        1/41 (2%)        0/38 (0%)     |  2/46 (4%)        3/48 (6%)        0/43 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             2.8%             0.0%          |  4.5%             6.8%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        1/28 (4%)        0/24 (0%)     |  2/42 (5%)        3/32 (9%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  735 (T)          735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.764N         P=0.444          (e)           |  P=0.346N         P=0.377          P=0.401N        |
|POLY 3             |        P=0.737N         P=0.475          (e)           |  P=0.239N         P=0.497          P=0.298N        |
|POLY 1.5           |        P=0.731N         P=0.481          (e)           |  P=0.212N         P=0.510          P=0.277N        |
|POLY 6             |        P=0.746N         P=0.467          (e)           |  P=0.279N         P=0.475          P=0.328N        |
|LOGISTIC REGRESSION|        (e)              P=0.444          (e)           |  P=0.346N         P=0.377          (e)             |
|COCH-ARM / FISHERS |        P=0.723N         P=0.488          (e)           |  P=0.181N         P=0.520          P=0.264N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        39/50 (78%)      42/50 (84%)      41/50 (82%)   |  45/50 (90%)      46/50 (92%)      38/50 (76%)     |
|POLY-3 ADJUSTED (b)|        80.7%            90.5%            90.2%         |  94.9%            95.6%            86.8%           |
|TERMINAL (d)       |        31/37 (84%)      29/29 (100%)     27/27 (100%)  |  42/42 (100%)     33/33 (100%)     21/21 (100%)    |
|FIRST INCIDENCE    |        559              475              370           |  664              658              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.014 *        P=0.017 *        P=0.010 *     |  P<0.001 **       P=0.007 **       P<0.001 **      |
|POLY 3             |        P=0.125          P=0.122          P=0.134       |  P=0.045N*        P=0.661          P=0.109N        |
|POLY 1.5           |        P=0.238          P=0.191          P=0.237       |  P=0.029N*        P=0.615          P=0.073N        |
|POLY 6             |        P=0.036 *        P=0.059          P=0.050       |  P=0.095N         P=0.710          P=0.216N        |
|LOGISTIC REGRESSION|        P=0.105          P=0.083          P=0.088       |  P=0.428          P=0.279          P=0.638         |
|COCH-ARM / FISHERS |        P=0.411          P=0.306          P=0.402       |  P=0.019N*        P=0.500          P=0.054N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        1/50 (2%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             2.4%          |  0.0%             4.3%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              657              645           |  ---              658              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.447          P=0.195          P=0.466       |  P=0.676N         P=0.224          (e)             |
|POLY 3             |        P=0.451          P=0.220          P=0.480       |  P=0.649N         P=0.235          (e)             |
|POLY 1.5           |        P=0.471          P=0.227          P=0.488       |  P=0.619N         P=0.237          (e)             |
|POLY 6             |        P=0.428          P=0.212          P=0.470       |  P=0.687N         P=0.229          (e)             |
|LOGISTIC REGRESSION|        P=0.551          P=0.270          P=0.572       |  P=0.545N         P=0.215          (e)             |
|COCH-ARM / FISHERS |        P=0.500          P=0.247          P=0.500       |  P=0.575N         P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        14/50 (28%)      10/50 (20%)   |  1/50 (2%)        11/50 (22%)      13/50 (26%)     |
|POLY-3 ADJUSTED (b)|        6.4%             30.6%            22.9%         |  2.1%             23.8%            31.2%           |
|TERMINAL (d)       |        2/37 (5%)        6/29 (21%)       5/27 (19%)    |  0/42 (0%)        10/33 (30%)      6/21 (29%)      |
|FIRST INCIDENCE    |        559              475              370           |  593              617              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.059          P=0.002 **       P=0.016 *     |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P=0.073          P=0.002 **       P=0.024 *     |  P<0.001 **       P=0.002 **       P<0.001 **      |
|POLY 1.5           |        P=0.088          P=0.002 **       P=0.029 *     |  P<0.001 **       P=0.002 **       P<0.001 **      |
|POLY 6             |        P=0.056          P=0.002 **       P=0.020 *     |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P=0.231          P=0.013 *        P=0.081       |  P=0.005 **       P=0.003 **       P=0.002 **      |
|COCH-ARM / FISHERS |        P=0.116          P=0.003 **       P=0.036 *     |  P=0.003 **       P=0.002 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        2/50 (4%)     |  1/50 (2%)        1/50 (2%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.8%          |  2.1%             2.2%             2.6%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              706           |  593              617              594             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.074          (e)              P=0.188       |  P=0.626          P=0.758N         P=0.722         |
|POLY 3             |        P=0.082          (e)              P=0.215       |  P=0.612          P=0.755          P=0.712         |
|POLY 1.5           |        P=0.085          (e)              P=0.224       |  P=0.640          P=0.759          P=0.733         |
|POLY 6             |        P=0.077          (e)              P=0.204       |  P=0.576          P=0.748          P=0.684         |
|LOGISTIC REGRESSION|        P=0.080          (e)              P=0.211       |  P=0.532N         P=0.701          P=0.687N        |
|COCH-ARM / FISHERS |        P=0.091          (e)              P=0.247       |  P=0.680N         P=0.753N         P=0.753N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Epicardium                                                                                                                |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        0/50 (0%)     |  1/50 (2%)        0/50 (0%)        7/50 (14%)      |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             0.0%          |  2.1%             0.0%             17.5%           |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        2/21 (10%)      |
|FIRST INCIDENCE    |        ---              625              ---           |  699              ---              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.726N         P=0.491          (e)           |  P<0.001 **       P=0.535N         P=0.007 **      |
|POLY 3             |        P=0.723N         P=0.484          (e)           |  P<0.001 **       P=0.505N         P=0.016 *       |
|POLY 1.5           |        P=0.715N         P=0.490          (e)           |  P=0.002 **       P=0.501N         P=0.021 *       |
|POLY 6             |        P=0.732N         P=0.475          (e)           |  P<0.001 **       P=0.512N         P=0.011 *       |
|LOGISTIC REGRESSION|        P=0.653N         P=0.612          (e)           |  P=0.008 **       P=0.503N         P=0.048 *       |
|COCH-ARM / FISHERS |        P=0.704N         P=0.500          (e)           |  P=0.003 **       P=0.500N         P=0.030 *       |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Pericardium                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        5/50 (10%)    |  0/50 (0%)        0/50 (0%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             12.0%         |  0.0%             0.0%             10.5%           |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        3/27 (11%)    |  0/42 (0%)        0/33 (0%)        3/21 (14%)      |
|FIRST INCIDENCE    |        ---              ---              668           |  ---              ---              695             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.002 **       (e)              P=0.016 *     |  P<0.001 **       (e)              P=0.012 *       |
|POLY 3             |        P=0.002 **       (e)              P=0.023 *     |  P=0.006 **       (e)              P=0.038 *       |
|POLY 1.5           |        P=0.003 **       (e)              P=0.026 *     |  P=0.007 **       (e)              P=0.047 *       |
|POLY 6             |        P=0.002 **       (e)              P=0.020 *     |  P=0.005 **       (e)              P=0.030 *       |
|LOGISTIC REGRESSION|        P=0.002 **       (e)              P=0.022 *     |  P=0.003 **       (e)              P=0.022 *       |
|COCH-ARM / FISHERS |        P=0.004 **       (e)              P=0.028 *     |  P=0.011 *        (e)              P=0.059         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Ileum: Peyer's Patch                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/45 (11%)       0/43 (0%)        1/45 (2%)     |  2/46 (4%)        0/50 (0%)        1/48 (2%)       |
|POLY-3 ADJUSTED (b)|        11.7%            0.0%             2.5%          |  4.5%             0.0%             2.7%            |
|TERMINAL (d)       |        4/37 (11%)       0/29 (0%)        1/27 (4%)     |  2/42 (5%)        0/33 (0%)        1/21 (5%)       |
|FIRST INCIDENCE    |        590              ---              733 (T)       |  735 (T)          ---              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.142N         P=0.056N         P=0.181N      |  P=0.695          P=0.293N         P=0.733         |
|POLY 3             |        P=0.089N         P=0.042N*        P=0.121N      |  P=0.510N         P=0.230N         P=0.557N        |
|POLY 1.5           |        P=0.087N         P=0.038N*        P=0.112N      |  P=0.504N         P=0.224N         P=0.525N        |
|POLY 6             |        P=0.092N         P=0.046N*        P=0.136N      |  P=0.517N         P=0.242N         P=0.599N        |
|LOGISTIC REGRESSION|        P=0.094N         P=0.034N*        P=0.104N      |  P=0.695          (e)              P=0.733         |
|COCH-ARM / FISHERS |        P=0.090N         P=0.031N*        P=0.101N      |  P=0.492N         P=0.227N         P=0.484N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        8/50 (16%)       3/49 (6%)        4/47 (9%)     |  2/50 (4%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        17.2%            7.2%             9.9%          |  4.2%             4.4%             2.6%            |
|TERMINAL (d)       |        6/37 (16%)       3/29 (10%)       3/27 (11%)    |  0/42 (0%)        2/33 (6%)        1/21 (5%)       |
|FIRST INCIDENCE    |        590              733 (T)          715           |  664              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.341N         P=0.190N         P=0.351N      |  P=0.624N         P=0.631          P=0.685N        |
|POLY 3             |        P=0.241N         P=0.137N         P=0.253N      |  P=0.481N         P=0.683          P=0.575N        |
|POLY 1.5           |        P=0.231N         P=0.123N         P=0.233N      |  P=0.450N         P=0.690          P=0.544N        |
|POLY 6             |        P=0.258N         P=0.157N         P=0.281N      |  P=0.520N         P=0.668          P=0.614N        |
|LOGISTIC REGRESSION|        P=0.282N         P=0.148N         P=0.268N      |  P=0.481N         P=0.695          P=0.539N        |
|COCH-ARM / FISHERS |        P=0.220N         P=0.106N         P=0.210N      |  P=0.404N         P=0.691N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Amyloid Deposition                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/49 (0%)        2/50 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.7%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              533           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.084          (e)              P=0.217       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.084          (e)              P=0.219       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.087          (e)              P=0.226       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.081          (e)              P=0.210       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.154          (e)              P=0.414       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.093          (e)              P=0.247       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/49 (0%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        4.3%             0.0%             0.0%          |  0.0%             2.2%             0.0%            |
|TERMINAL (d)       |        2/37 (5%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          ---              ---           |  ---              547              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.216N         P=0.293N         P=0.310N      |  P=0.734N         P=0.508          (e)             |
|POLY 3             |        P=0.170N         P=0.260N         P=0.262N      |  P=0.740N         P=0.498          (e)             |
|POLY 1.5           |        P=0.170N         P=0.253N         P=0.252N      |  P=0.725N         P=0.500          (e)             |
|POLY 6             |        P=0.171N         P=0.271N         P=0.275N      |  P=0.757N         P=0.493          (e)             |
|LOGISTIC REGRESSION|        P=0.216N         (e)              (e)           |  P=0.589N         P=0.361          (e)             |
|COCH-ARM / FISHERS |        P=0.171N         P=0.253N         P=0.247N      |  P=0.704N         P=0.500          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/49 (0%)        2/50 (4%)     |  1/50 (2%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.8%          |  2.1%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        1/27 (4%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              671           |  593              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.070          (e)              P=0.184       |  P=0.423N         P=0.500N         P=0.536N        |
|POLY 3             |        P=0.083          (e)              P=0.215       |  P=0.391N         P=0.506N         P=0.543N        |
|POLY 1.5           |        P=0.086          (e)              P=0.224       |  P=0.394N         P=0.502N         P=0.525N        |
|POLY 6             |        P=0.078          (e)              P=0.205       |  P=0.385N         P=0.514N         P=0.566N        |
|LOGISTIC REGRESSION|        P=0.085          (e)              P=0.222       |  P=0.308N         P=0.588N         P=0.426N        |
|COCH-ARM / FISHERS |        P=0.093          (e)              P=0.247       |  P=0.394N         P=0.500N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Metaplasia Osseous                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       2/49 (4%)        1/50 (2%)     |  2/50 (4%)        4/50 (8%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        10.8%            4.8%             2.4%          |  4.3%             8.7%             5.2%            |
|TERMINAL (d)       |        4/37 (11%)       2/29 (7%)        1/27 (4%)     |  1/42 (2%)        3/33 (9%)        1/21 (5%)       |
|FIRST INCIDENCE    |        726              733 (T)          733 (T)       |  715              685              633             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.153N         P=0.325N         P=0.190N      |  P=0.422          P=0.250          P=0.482         |
|POLY 3             |        P=0.100N         P=0.259N         P=0.128N      |  P=0.569          P=0.328          P=0.619         |
|POLY 1.5           |        P=0.094N         P=0.245N         P=0.117N      |  P=0.603N         P=0.336          P=0.651         |
|POLY 6             |        P=0.109N         P=0.279N         P=0.144N      |  P=0.504          P=0.314          P=0.577         |
|LOGISTIC REGRESSION|        P=0.142N         P=0.320N         P=0.174N      |  P=0.598          P=0.321          P=0.647         |
|COCH-ARM / FISHERS |        P=0.087N         P=0.226N         P=0.102N      |  P=0.539N         P=0.339          P=0.691N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        47/50 (94%)      41/49 (84%)      41/50 (82%)   |  37/50 (74%)      43/50 (86%)      36/50 (72%)     |
|POLY-3 ADJUSTED (b)|        95.9%            88.8%            90.4%         |  76.9%            89.5%            82.8%           |
|TERMINAL (d)       |        36/37 (97%)      28/29 (97%)      27/27 (100%)  |  34/42 (81%)      31/33 (94%)      18/21 (86%)     |
|FIRST INCIDENCE    |        561              475              562           |  264              617              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.155          P=0.299          P=0.152       |  P<0.001 **       P=0.003 **       P<0.001 **      |
|POLY 3             |        P=0.247N         P=0.148N         P=0.217N      |  P=0.351          P=0.071          P=0.320         |
|POLY 1.5           |        P=0.153N         P=0.117N         P=0.122N      |  P=0.515          P=0.085          P=0.452         |
|POLY 6             |        P=0.449N         P=0.221N         P=0.463N      |  P=0.200          P=0.055          P=0.198         |
|LOGISTIC REGRESSION|        P=0.340N         P=0.270N         P=0.424N      |  P=0.202          P=0.093          P=0.263         |
|COCH-ARM / FISHERS |        P=0.081N         P=0.094N         P=0.061N      |  P=0.338N         P=0.105          P=0.500N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Artery                                                                                                                   |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        6/49 (12%)       2/50 (4%)     |  0/50 (0%)        1/50 (2%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             14.2%            4.8%          |  0.0%             2.2%             7.6%            |
|TERMINAL (d)       |        0/37 (0%)        4/29 (14%)       1/27 (4%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              491              685           |  ---              617              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.349          P=0.010 *        P=0.183       |  P=0.041 *        P=0.504          P=0.085         |
|POLY 3             |        P=0.380          P=0.011 *        P=0.215       |  P=0.048 *        P=0.497          P=0.091         |
|POLY 1.5           |        P=0.413          P=0.012 *        P=0.224       |  P=0.055          P=0.500          P=0.102         |
|POLY 6             |        P=0.340          P=0.010 *        P=0.204       |  P=0.040 *        P=0.492          P=0.079         |
|LOGISTIC REGRESSION|        P=0.452          P=0.017 *        P=0.213       |  P=0.158          P=0.436          P=0.191         |
|COCH-ARM / FISHERS |        P=0.463          P=0.012 *        P=0.247       |  P=0.068          P=0.500          P=0.121         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Capsule                                                                                                                  |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/49 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              491              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.597N         P=0.223          (e)           |  (e)              (e)              (e)             |
|POLY 3             |        P=0.614N         P=0.220          (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.598N         P=0.225          (e)           |  (e)              (e)              (e)             |
|POLY 6             |        P=0.633N         P=0.214          (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.377N         P=0.467          (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.574N         P=0.242          (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       3/49 (6%)        5/50 (10%)    |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        10.7%            7.2%             12.1%         |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        3/37 (8%)        3/29 (10%)       5/27 (19%)    |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        590              733 (T)          733 (T)       |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.362          P=0.489N         P=0.441       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.469          P=0.422N         P=0.552       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.496          P=0.399N         P=0.584       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.433          P=0.452N         P=0.508       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.437          P=0.400N         P=0.548       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.534          P=0.369N         P=0.630N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       1/49 (2%)        4/50 (8%)     |  0/50 (0%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        10.5%            2.4%             9.7%          |  0.0%             2.2%             5.2%            |
|TERMINAL (d)       |        1/37 (3%)        0/29 (0%)        4/27 (15%)    |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        559              650              733 (T)       |  ---              729              695             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.512          P=0.151N         P=0.614       |  P=0.084          P=0.458          P=0.139         |
|POLY 3             |        P=0.592          P=0.132N         P=0.585N      |  P=0.132          P=0.496          P=0.195         |
|POLY 1.5           |        P=0.589N         P=0.121N         P=0.550N      |  P=0.148          P=0.499          P=0.212         |
|POLY 6             |        P=0.564          P=0.148N         P=0.629N      |  P=0.113          P=0.489          P=0.176         |
|LOGISTIC REGRESSION|        P=0.546N         P=0.043N*        P=0.475N      |  P=0.128          P=0.482          P=0.199         |
|COCH-ARM / FISHERS |        P=0.567N         P=0.107N         P=0.500N      |  P=0.175          P=0.500          P=0.247         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Squamous Epithelium                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       4/49 (8%)        7/50 (14%)    |  9/50 (18%)       10/50 (20%)      15/50 (30%)     |
|POLY-3 ADJUSTED (b)|        12.8%            9.2%             15.7%         |  19.2%            21.3%            35.3%           |
|TERMINAL (d)       |        4/37 (11%)       0/29 (0%)        1/27 (4%)     |  9/42 (21%)       6/33 (18%)       2/21 (10%)      |
|FIRST INCIDENCE    |        590              478              370           |  735 (T)          617              487             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.291          P=0.479N         P=0.360       |  P=0.004 **       P=0.321          P=0.009 **      |
|POLY 3             |        P=0.367          P=0.420N         P=0.460       |  P=0.047 *        P=0.501          P=0.068         |
|POLY 1.5           |        P=0.380          P=0.405N         P=0.478       |  P=0.059          P=0.507          P=0.085         |
|POLY 6             |        P=0.347          P=0.439N         P=0.434       |  P=0.037 *        P=0.486          P=0.053         |
|LOGISTIC REGRESSION|        P=0.504N         P=0.236N         P=0.416N      |  P=0.103          P=0.489          P=0.127         |
|COCH-ARM / FISHERS |        P=0.395          P=0.383N         P=0.500       |  P=0.088          P=0.500          P=0.121         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        2.2%             0.0%             0.0%          |  0.0%             2.2%             5.3%            |
|TERMINAL (d)       |        1/37 (3%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        1/33 (3%)        2/21 (10%)      |
|FIRST INCIDENCE    |        733 (T)          ---              ---           |  ---              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.441N         P=0.549N         P=0.563N      |  P=0.063          P=0.452          P=0.104         |
|POLY 3             |        P=0.388N         P=0.518N         P=0.522N      |  P=0.130          P=0.496          P=0.194         |
|POLY 1.5           |        P=0.390N         P=0.511N         P=0.513N      |  P=0.148          P=0.499          P=0.211         |
|POLY 6             |        P=0.386N         P=0.528N         P=0.533N      |  P=0.111          P=0.489          P=0.174         |
|LOGISTIC REGRESSION|        P=0.441N         (e)              (e)           |  (e)              P=0.452          P=0.104         |
|COCH-ARM / FISHERS |        P=0.394N         P=0.500N         P=0.500N      |  P=0.175          P=0.500          P=0.247         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        4.3%             4.7%             0.0%          |  4.3%             0.0%             5.1%            |
|TERMINAL (d)       |        0/37 (0%)        1/29 (3%)        0/27 (0%)     |  2/42 (5%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        559              475              ---           |  735 (T)          ---              496             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.213N         P=0.641          P=0.283N      |  P=0.421          P=0.293N         P=0.543         |
|POLY 3             |        P=0.198N         P=0.663          P=0.265N      |  P=0.510          P=0.242N         P=0.627         |
|POLY 1.5           |        P=0.187N         P=0.676          P=0.254N      |  P=0.526          P=0.239N         P=0.655         |
|POLY 6             |        P=0.212N         P=0.645          P=0.280N      |  P=0.489          P=0.250N         P=0.590         |
|LOGISTIC REGRESSION|        P=0.086N         P=0.498N         P=0.146N      |  P=0.654N         (e)              P=0.625N        |
|COCH-ARM / FISHERS |        P=0.172N         P=0.691N         P=0.247N      |  P=0.554          P=0.247N         P=0.691N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)     |  2/50 (4%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        4.3%             4.7%             0.0%          |  4.3%             0.0%             5.2%            |
|TERMINAL (d)       |        2/37 (5%)        2/29 (7%)        0/27 (0%)     |  2/42 (5%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          733 (T)          ---           |  735 (T)          ---              695             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.238N         P=0.605          P=0.310N      |  P=0.360          P=0.293N         P=0.466         |
|POLY 3             |        P=0.194N         P=0.661          P=0.262N      |  P=0.504          P=0.242N         P=0.618         |
|POLY 1.5           |        P=0.185N         P=0.675          P=0.252N      |  P=0.523          P=0.239N         P=0.650         |
|POLY 6             |        P=0.207N         P=0.643          P=0.275N      |  P=0.482          P=0.250N         P=0.575         |
|LOGISTIC REGRESSION|        P=0.238N         P=0.605          (e)           |  P=0.438          (e)              P=0.569         |
|COCH-ARM / FISHERS |        P=0.172N         P=0.691N         P=0.247N      |  P=0.554          P=0.247N         P=0.691N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        10/50 (20%)      19/50 (38%)      18/50 (36%)   |  6/50 (12%)       4/50 (8%)        12/50 (24%)     |
|POLY-3 ADJUSTED (b)|        21.3%            43.9%            42.2%         |  12.7%            8.7%             30.5%           |
|TERMINAL (d)       |        8/37 (22%)       16/29 (55%)      14/27 (52%)   |  4/42 (10%)       4/33 (12%)       9/21 (43%)      |
|FIRST INCIDENCE    |        590              491              589           |  678              735 (T)          533             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.012 *        P=0.007 **       P=0.008 **    |  P<0.001 **       P=0.511N         P=0.003 **      |
|POLY 3             |        P=0.037 *        P=0.016 *        P=0.025 *     |  P=0.014 *        P=0.388N         P=0.037 *       |
|POLY 1.5           |        P=0.055          P=0.023 *        P=0.036 *     |  P=0.021 *        P=0.376N         P=0.056         |
|POLY 6             |        P=0.022 *        P=0.009 **       P=0.016 *     |  P=0.009 **       P=0.414N         P=0.021 *       |
|LOGISTIC REGRESSION|        P=0.039 *        P=0.018 *        P=0.026 *     |  P=0.009 **       P=0.401N         P=0.035 *       |
|COCH-ARM / FISHERS |        P=0.094          P=0.038 *        P=0.059       |  P=0.037 *        P=0.370N         P=0.096         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        0/50 (0%)        0/50 (0%)     |  3/50 (6%)        4/50 (8%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        2.2%             0.0%             0.0%          |  6.3%             8.6%             7.7%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  1/42 (2%)        2/33 (6%)        1/21 (5%)       |
|FIRST INCIDENCE    |        669              ---              ---           |  664              672              578             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.429N         P=0.535N         P=0.547N      |  P=0.385          P=0.433          P=0.453         |
|POLY 3             |        P=0.388N         P=0.519N         P=0.523N      |  P=0.519          P=0.488          P=0.569         |
|POLY 1.5           |        P=0.390N         P=0.511N         P=0.513N      |  P=0.567          P=0.497          P=0.608         |
|POLY 6             |        P=0.385N         P=0.530N         P=0.534N      |  P=0.457          P=0.469          P=0.518         |
|LOGISTIC REGRESSION|        P=0.371N         P=0.460N         P=0.464N      |  P=0.526N         P=0.494          P=0.626N        |
|COCH-ARM / FISHERS |        P=0.394N         P=0.500N         P=0.500N      |  P=0.569N         P=0.500          P=0.661N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/50 (8%)        2/50 (4%)        7/50 (14%)    |  4/50 (8%)        9/50 (18%)       3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        8.5%             4.7%             16.4%         |  8.5%             19.5%            7.8%            |
|TERMINAL (d)       |        1/37 (3%)        0/29 (0%)        1/27 (4%)     |  2/42 (5%)        6/33 (18%)       0/21 (0%)       |
|FIRST INCIDENCE    |        607              678              501           |  678              685              658             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.090          P=0.432N         P=0.163       |  P=0.481          P=0.063          P=0.534         |
|POLY 3             |        P=0.114          P=0.385N         P=0.207       |  P=0.475N         P=0.107          P=0.606N        |
|POLY 1.5           |        P=0.124          P=0.365N         P=0.229       |  P=0.405N         P=0.114          P=0.563N        |
|POLY 6             |        P=0.102          P=0.411N         P=0.182       |  P=0.563N         P=0.095          P=0.645         |
|LOGISTIC REGRESSION|        P=0.167          P=0.253N         P=0.337       |  P=0.436N         P=0.108          P=0.555N        |
|COCH-ARM / FISHERS |        P=0.139          P=0.339N         P=0.262       |  P=0.310N         P=0.117          P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Tension Lipidosis                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/50 (0%)        0/50 (0%)     |  2/50 (4%)        2/50 (4%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        4.3%             0.0%             0.0%          |  4.3%             4.4%             2.6%            |
|TERMINAL (d)       |        2/37 (5%)        0/29 (0%)        0/27 (0%)     |  2/42 (5%)        2/33 (6%)        1/21 (5%)       |
|FIRST INCIDENCE    |        733 (T)          ---              ---           |  735 (T)          735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.216N         P=0.293N         P=0.310N      |  P=0.655          P=0.605          P=0.733         |
|POLY 3             |        P=0.169N         P=0.258N         P=0.262N      |  P=0.478N         P=0.686          P=0.572N        |
|POLY 1.5           |        P=0.169N         P=0.249N         P=0.252N      |  P=0.449N         P=0.692          P=0.542N        |
|POLY 6             |        P=0.169N         P=0.269N         P=0.275N      |  P=0.515N         P=0.674          P=0.610N        |
|LOGISTIC REGRESSION|        P=0.216N         (e)              (e)           |  P=0.655          P=0.605          P=0.733         |
|COCH-ARM / FISHERS |        P=0.171N         P=0.247N         P=0.247N      |  P=0.404N         P=0.691N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        1/50 (2%)        0/50 (0%)     |  1/50 (2%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        4.3%             2.4%             0.0%          |  2.1%             2.2%             0.0%            |
|TERMINAL (d)       |        2/37 (5%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          625              ---           |  715              699              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.223N         P=0.561N         P=0.310N      |  P=0.470N         P=0.718          P=0.616N        |
|POLY 3             |        P=0.188N         P=0.528N         P=0.262N      |  P=0.394N         P=0.756          P=0.542N        |
|POLY 1.5           |        P=0.183N         P=0.517N         P=0.252N      |  P=0.377N         P=0.759          P=0.524N        |
|POLY 6             |        P=0.196N         P=0.543N         P=0.275N      |  P=0.415N         P=0.749          P=0.564N        |
|LOGISTIC REGRESSION|        P=0.178N         P=0.498N         (e)           |  P=0.375N         P=0.762          P=0.552N        |
|COCH-ARM / FISHERS |        P=0.175N         P=0.500N         P=0.247N      |  P=0.352N         P=0.753N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        42/50 (84%)      49/50 (98%)   |  0/50 (0%)        35/50 (70%)      49/50 (98%)     |
|POLY-3 ADJUSTED (b)|        0.0%             85.0%            98.0%         |  0.0%             71.4%            98.0%           |
|TERMINAL (d)       |        0/37 (0%)        23/29 (79%)      26/27 (96%)   |  0/42 (0%)        22/33 (67%)      20/21 (95%)     |
|FIRST INCIDENCE    |        ---              475              370           |  ---              547              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       2/50 (4%)        2/50 (4%)     |  4/50 (8%)        4/50 (8%)        4/50 (8%)       |
|POLY-3 ADJUSTED (b)|        10.7%            4.7%             4.8%          |  8.5%             8.6%             9.8%            |
|TERMINAL (d)       |        3/37 (8%)        2/29 (7%)        1/27 (4%)     |  4/42 (10%)       2/33 (6%)        0/21 (0%)       |
|FIRST INCIDENCE    |        664              733 (T)          668           |  735 (T)          617              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.310N         P=0.318N         P=0.340N      |  P=0.345          P=0.541          P=0.420         |
|POLY 3             |        P=0.230N         P=0.259N         P=0.264N      |  P=0.505          P=0.639          P=0.563         |
|POLY 1.5           |        P=0.219N         P=0.241N         P=0.244N      |  P=0.544          P=0.642N         P=0.599         |
|POLY 6             |        P=0.246N         P=0.285N         P=0.291N      |  P=0.455          P=0.626          P=0.514         |
|LOGISTIC REGRESSION|        P=0.245N         P=0.258N         P=0.240N      |  P=0.346N         P=0.644          P=0.435N        |
|COCH-ARM / FISHERS |        P=0.204N         P=0.218N         P=0.218N      |  P=0.595N         P=0.643N         P=0.643N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        45/50 (90%)      46/50 (92%)   |  2/50 (4%)        45/50 (90%)      50/50 (100%)    |
|POLY-3 ADJUSTED (b)|        4.3%             93.6%            95.5%         |  4.3%             92.9%            100.0%          |
|TERMINAL (d)       |        2/37 (5%)        28/29 (97%)      26/27 (96%)   |  2/42 (5%)        33/33 (100%)     21/21 (100%)    |
|FIRST INCIDENCE    |        733 (T)          475              370           |  735 (T)          617              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        3/50 (6%)        7/50 (14%)    |  0/50 (0%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        4.3%             7.1%             16.9%         |  0.0%             2.2%             5.3%            |
|TERMINAL (d)       |        2/37 (5%)        3/29 (10%)       7/27 (26%)    |  0/42 (0%)        1/33 (3%)        2/21 (10%)      |
|FIRST INCIDENCE    |        733 (T)          733 (T)          733 (T)       |  ---              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.014 *        P=0.389          P=0.025 *     |  P=0.063          P=0.452          P=0.104         |
|POLY 3             |        P=0.031 *        P=0.459          P=0.055       |  P=0.130          P=0.496          P=0.194         |
|POLY 1.5           |        P=0.036 *        P=0.476          P=0.064       |  P=0.148          P=0.499          P=0.211         |
|POLY 6             |        P=0.025 *        P=0.437          P=0.045 *     |  P=0.111          P=0.489          P=0.174         |
|LOGISTIC REGRESSION|        P=0.014 *        P=0.389          P=0.025 *     |  (e)              P=0.452          P=0.104         |
|COCH-ARM / FISHERS |        P=0.046 *        P=0.500          P=0.080       |  P=0.175          P=0.500          P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        2/50 (4%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             4.3%             7.9%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        1/33 (3%)        3/21 (14%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              691              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.027 *        P=0.198          P=0.031 *       |
|POLY 3             |        (e)              (e)              (e)           |  P=0.071          P=0.233          P=0.086         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.086          P=0.237          P=0.098         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.055          P=0.226          P=0.072         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.045 *        P=0.237          P=0.031 *       |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.112          P=0.247          P=0.121         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Proteinosis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        10/50 (20%)   |  0/50 (0%)        0/50 (0%)        8/50 (16%)      |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             22.7%         |  0.0%             0.0%             19.4%           |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        5/27 (19%)    |  0/42 (0%)        0/33 (0%)        3/21 (14%)      |
|FIRST INCIDENCE    |        ---              ---              370           |  ---              ---              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       (e)              P<0.001 **    |  P<0.001 **       (e)              P<0.001 **      |
|POLY 3             |        P<0.001 **       (e)              P<0.001 **    |  P<0.001 **       (e)              P=0.002 **      |
|POLY 1.5           |        P<0.001 **       (e)              P<0.001 **    |  P<0.001 **       (e)              P=0.003 **      |
|POLY 6             |        P<0.001 **       (e)              P<0.001 **    |  P<0.001 **       (e)              P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.004 **    |  P=0.002 **       (e)              P=0.017 *       |
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P<0.001 **    |  P<0.001 **       (e)              P=0.003 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Artery, Mediastinum                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        1/50 (2%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             4.7%             0.0%          |  0.0%             2.2%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        1/29 (3%)        0/27 (0%)     |  0/42 (0%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              491              ---           |  ---              735 (T)          ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.612N         P=0.207          (e)           |  P=0.809          P=0.452          (e)             |
|POLY 3             |        P=0.615N         P=0.221          (e)           |  P=0.740N         P=0.496          (e)             |
|POLY 1.5           |        P=0.599N         P=0.228          (e)           |  P=0.725N         P=0.499          (e)             |
|POLY 6             |        P=0.634N         P=0.212          (e)           |  P=0.757N         P=0.489          (e)             |
|LOGISTIC REGRESSION|        P=0.461N         P=0.369          (e)           |  (e)              P=0.452          (e)             |
|COCH-ARM / FISHERS |        P=0.575N         P=0.247          (e)           |  P=0.704N         P=0.500          (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Bronchiole, Bronchus                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             0.0%             5.3%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        1/21 (5%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              ---              727             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.035 *        (e)              P=0.113         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.072          (e)              P=0.194         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.079          (e)              P=0.211         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.065          (e)              P=0.174         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.042 *        (e)              P=0.134         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.091          (e)              P=0.247         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Interstitium                                                                                                               |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/50 (0%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             0.0%             5.1%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              ---              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.082          (e)              P=0.222         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.075          (e)              P=0.201         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.081          (e)              P=0.215         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.068          (e)              P=0.182         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.210          (e)              P=0.367         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.091          (e)              P=0.247         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Serosa                                                                                                                     |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        49/50 (98%)      50/50 (100%)  |  0/50 (0%)        47/50 (94%)      49/50 (98%)     |
|POLY-3 ADJUSTED (b)|        0.0%             99.4%            100.0%        |  0.0%             96.5%            98.0%           |
|TERMINAL (d)       |        0/37 (0%)        29/29 (100%)     27/27 (100%)  |  0/42 (0%)        33/33 (100%)     20/21 (95%)     |
|FIRST INCIDENCE    |        ---              475              370           |  ---              617              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/35 (0%)        40/45 (89%)      40/48 (83%)   |  0/36 (0%)        33/48 (69%)      40/50 (80%)     |
|POLY-3 ADJUSTED (b)|        0.0%             90.8%            85.5%         |  0.0%             71.2%            81.5%           |
|TERMINAL (d)       |        0/30 (0%)        22/24 (92%)      22/27 (82%)   |  0/29 (0%)        22/32 (69%)      16/21 (76%)     |
|FIRST INCIDENCE    |        ---              475              370           |  ---              617              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/35 (6%)        22/45 (49%)      22/48 (46%)   |  5/36 (14%)       31/48 (65%)      28/50 (56%)     |
|POLY-3 ADJUSTED (b)|        5.9%             54.8%            52.7%         |  14.8%            67.4%            60.5%           |
|TERMINAL (d)       |        1/30 (3%)        14/24 (58%)      17/27 (63%)   |  5/29 (17%)       22/32 (69%)      12/21 (57%)     |
|FIRST INCIDENCE    |        664              475              562           |  735 (T)          617              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P<0.001 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P=0.009 **       P<0.001 **       P<0.001 **      |
|COCH-ARM / FISHERS |        P=0.002 **       P<0.001 **       P<0.001 **    |  P=0.003 **       P<0.001 **       P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/40 (0%)        14/45 (31%)      25/48 (52%)   |  0/42 (0%)        7/46 (15%)       16/49 (33%)     |
|POLY-3 ADJUSTED (b)|        0.0%             34.3%            56.9%         |  0.0%             16.5%            36.8%           |
|TERMINAL (d)       |        0/31 (0%)        8/27 (30%)       16/27 (59%)   |  0/37 (0%)        4/29 (14%)       7/21 (33%)      |
|FIRST INCIDENCE    |        ---              491              370           |  ---              658              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.006 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.009 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.009 **       P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.007 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P=0.002 **       P=0.012 *        P=0.002 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.008 **       P<0.001 **      |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/40 (0%)        17/45 (38%)      27/48 (56%)   |  2/42 (5%)        11/46 (24%)      29/49 (59%)     |
|POLY-3 ADJUSTED (b)|        0.0%             41.9%            61.4%         |  5.0%             25.7%            62.7%           |
|TERMINAL (d)       |        0/31 (0%)        11/27 (41%)      17/27 (63%)   |  2/37 (5%)        6/29 (21%)       12/21 (57%)     |
|FIRST INCIDENCE    |        ---              562              370           |  735 (T)          664              197             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.004 **       P<0.001 **      |
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.009 **       P<0.001 **      |
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.010 *        P<0.001 **      |
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.007 **       P<0.001 **      |
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.012 *        P<0.001 **      |
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **    |  P<0.001 **       P=0.011 *        P<0.001 **      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal: Artery                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/40 (0%)        2/45 (4%)        1/48 (2%)     |  0/42 (0%)        0/46 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             5.2%             2.5%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/31 (0%)        2/27 (7%)        1/27 (4%)     |  0/37 (0%)        0/29 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              733 (T)          733 (T)       |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.465          P=0.208          P=0.472       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.498          P=0.246          P=0.516       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.519          P=0.254          P=0.524       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.472          P=0.236          P=0.505       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              P=0.208          P=0.472       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.549          P=0.277          P=0.545       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        11/48 (23%)      10/49 (20%)      10/45 (22%)   |  8/48 (17%)       7/50 (14%)       7/48 (15%)      |
|POLY-3 ADJUSTED (b)|        24.7%            23.4%            26.1%         |  17.6%            15.1%            18.7%           |
|TERMINAL (d)       |        9/36 (25%)       6/29 (21%)       9/26 (35%)    |  7/41 (17%)       4/33 (12%)       4/21 (19%)      |
|FIRST INCIDENCE    |        669              625              645           |  678              672              533             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.360          P=0.488          P=0.374       |  P=0.225          P=0.568          P=0.268         |
|POLY 3             |        P=0.496          P=0.541N         P=0.544       |  P=0.506          P=0.485N         P=0.564         |
|POLY 1.5           |        P=0.529          P=0.517N         P=0.578       |  P=0.569          P=0.471N         P=0.595N        |
|POLY 6             |        P=0.455          P=0.569N         P=0.502       |  P=0.430          P=0.513N         P=0.481         |
|LOGISTIC REGRESSION|        P=0.462          P=0.577N         P=0.472       |  P=0.522          P=0.494N         P=0.586         |
|COCH-ARM / FISHERS |        P=0.554N         P=0.479N         P=0.567N      |  P=0.483N         P=0.465N         P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/48 (4%)        0/49 (0%)        0/45 (0%)     |  0/48 (0%)        0/50 (0%)        0/48 (0%)       |
|POLY-3 ADJUSTED (b)|        4.5%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        2/36 (6%)        0/29 (0%)        0/26 (0%)     |  0/41 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.217N         P=0.287N         P=0.312N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.176N         P=0.250N         P=0.272N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.177N         P=0.243N         P=0.264N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.176N         P=0.260N         P=0.282N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.217N         (e)              (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.179N         P=0.242N         P=0.264N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/0 (0%)         0/0 (0%)         0/0 (0%)      |  2/50 (4%)        4/50 (8%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.3%             8.7%             7.9%            |
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)      |  2/42 (5%)        2/33 (6%)        2/21 (10%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  735 (T)          691              709             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.205          P=0.247          P=0.221         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.374          P=0.329          P=0.407         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.425          P=0.336          P=0.445         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.312          P=0.315          P=0.360         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.294          P=0.308          P=0.292         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.500          P=0.339          P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/4 (0%)         1/5 (20%)        1/8 (13%)     |  0/13 (0%)        2/8 (25%)        1/4 (25%)       |
|POLY-3 ADJUSTED (b)|        0.0%             26.9%            15.2%         |  0.0%             26.3%            28.1%           |
|TERMINAL (d)       |        0/4 (0%)         1/2 (50%)        0/4 (0%)      |  0/12 (0%)        2/7 (29%)        1/2 (50%)       |
|FIRST INCIDENCE    |        ---              733 (T)          562           |  ---              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.436          P=0.362          P=0.487       |  P=0.073          P=0.125          P=0.154         |
|POLY 3             |        P=0.508          P=0.485          P=0.601       |  P=0.146          P=0.115          P=0.236         |
|POLY 1.5           |        P=0.545          P=0.512          P=0.616       |  P=0.158          P=0.117          P=0.243         |
|POLY 6             |        P=0.460          P=0.445          P=0.580       |  P=0.124          P=0.113          P=0.225         |
|LOGISTIC REGRESSION|        P=0.670          P=0.362          P=0.992       |  (e)              P=0.125          P=0.154         |
|COCH-ARM / FISHERS |        P=0.596          P=0.556          P=0.667       |  P=0.176          P=0.133          P=0.235         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/4 (100%)       4/5 (80%)        4/8 (50%)     |  10/13 (77%)      6/8 (75%)        3/4 (75%)       |
|POLY-3 ADJUSTED (b)|        100.0%           80.0%            63.1%         |  79.8%            75.0%            75.0%           |
|TERMINAL (d)       |        4/4 (100%)       1/2 (50%)        3/4 (75%)     |  10/12 (83%)      5/7 (71%)        1/2 (50%)       |
|FIRST INCIDENCE    |        733 (T)          562              648           |  735 (T)          617              645             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.602N         P=0.340          P=0.740       |  P=0.383          P=0.678N         P=0.410         |
|POLY 3             |        P=0.167N         P=0.544N         P=0.226N      |  P=0.590N         P=0.611N         P=0.686N        |
|POLY 1.5           |        P=0.111N         P=0.544N         P=0.167N      |  P=0.608N         P=0.632N         P=0.698N        |
|POLY 6             |        P=0.273N         P=0.544N         P=0.357N      |  P=0.566N         P=0.581N         P=0.666N        |
|LOGISTIC REGRESSION|        P=0.125N         (e)              P=0.596N      |  P=0.670          P=0.687N         P=0.709         |
|COCH-ARM / FISHERS |        P=0.073N         P=0.556N         P=0.141N      |  P=0.638N         P=0.656N         P=0.700N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/49 (6%)        4/49 (8%)        5/50 (10%)    |  7/50 (14%)       7/50 (14%)       2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        6.6%             9.5%             12.0%         |  14.7%            15.1%            5.3%            |
|TERMINAL (d)       |        2/36 (6%)        2/29 (7%)        4/27 (15%)    |  5/42 (12%)       4/33 (12%)       2/21 (10%)      |
|FIRST INCIDENCE    |        590              669              648           |  593              672              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.203          P=0.393          P=0.229       |  P=0.278N         P=0.467          P=0.302N        |
|POLY 3             |        P=0.269          P=0.454          P=0.308       |  P=0.127N         P=0.589          P=0.147N        |
|POLY 1.5           |        P=0.292          P=0.473          P=0.332       |  P=0.095N         P=0.604          P=0.115N        |
|POLY 6             |        P=0.241          P=0.433          P=0.280       |  P=0.180N         P=0.560          P=0.199N        |
|LOGISTIC REGRESSION|        P=0.287          P=0.506          P=0.328       |  P=0.099N         P=0.613          P=0.117N        |
|COCH-ARM / FISHERS |        P=0.327          P=0.500          P=0.369       |  P=0.060N         P=0.613N         P=0.080N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/49 (4%)        2/49 (4%)        1/50 (2%)     |  6/50 (12%)       3/50 (6%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        4.4%             4.8%             2.4%          |  12.8%            6.5%             5.2%            |
|TERMINAL (d)       |        2/36 (6%)        2/29 (7%)        1/27 (4%)     |  5/42 (12%)       2/33 (6%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          733 (T)          733 (T)       |  715              728              669             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.503N         P=0.615          P=0.600N      |  P=0.366N         P=0.369N         P=0.410N        |
|POLY 3             |        P=0.431N         P=0.664          P=0.530N      |  P=0.176N         P=0.253N         P=0.208N        |
|POLY 1.5           |        P=0.417N         P=0.676          P=0.515N      |  P=0.152N         P=0.245N         P=0.175N        |
|POLY 6             |        P=0.449N         P=0.648          P=0.549N      |  P=0.206N         P=0.271N         P=0.256N        |
|LOGISTIC REGRESSION|        P=0.503N         P=0.615          P=0.600N      |  P=0.234N         P=0.312N         P=0.246N        |
|COCH-ARM / FISHERS |        P=0.396N         P=0.691N         P=0.492N      |  P=0.121N         P=0.243N         P=0.134N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/49 (2%)        0/49 (0%)        0/50 (0%)     |  3/50 (6%)        10/50 (20%)      2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        2.2%             0.0%             0.0%          |  6.4%             21.8%            5.3%            |
|TERMINAL (d)       |        0/36 (0%)        0/29 (0%)        0/27 (0%)     |  3/42 (7%)        9/33 (27%)       2/21 (10%)      |
|FIRST INCIDENCE    |        561              ---              ---           |  735 (T)          699              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.404N         P=0.513N         P=0.513N      |  P=0.507          P=0.012 *        P=0.565         |
|POLY 3             |        P=0.384N         P=0.519N         P=0.520N      |  P=0.432N         P=0.031 *        P=0.594N        |
|POLY 1.5           |        P=0.387N         P=0.511N         P=0.510N      |  P=0.352N         P=0.034 *        P=0.555N        |
|POLY 6             |        P=0.382N         P=0.529N         P=0.532N      |  P=0.539N         P=0.027 *        P=0.642N        |
|LOGISTIC REGRESSION|        P=0.242N         P=0.251N         P=0.282N      |  P=0.589N         P=0.017 *        P=0.565         |
|COCH-ARM / FISHERS |        P=0.391N         P=0.500N         P=0.495N      |  P=0.256N         P=0.036 *        P=0.500N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        4/49 (8%)        3/49 (6%)        4/50 (8%)     |  28/50 (56%)      27/50 (54%)      14/50 (28%)     |
|POLY-3 ADJUSTED (b)|        8.8%             7.2%             9.4%          |  58.6%            56.9%            34.9%           |
|TERMINAL (d)       |        3/36 (8%)        2/29 (7%)        1/27 (4%)     |  25/42 (60%)      21/33 (64%)      6/21 (29%)      |
|FIRST INCIDENCE    |        561              672              608           |  593              547              496             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.449          P=0.600N         P=0.523       |  P=0.428N         P=0.232          P=0.452N        |
|POLY 3             |        P=0.532          P=0.549N         P=0.602       |  P=0.014N*        P=0.516N         P=0.019N*       |
|POLY 1.5           |        P=0.550          P=0.529N         P=0.622       |  P=0.006N**       P=0.494N         P=0.009N**      |
|POLY 6             |        P=0.511          P=0.573N         P=0.579       |  P=0.036N*        P=0.566N         P=0.045N*       |
|LOGISTIC REGRESSION|        P=0.598          P=0.506N         P=0.565N      |  P=0.022N*        P=0.533N         P=0.033N*       |
|COCH-ARM / FISHERS |        P=0.579          P=0.500N         P=0.631N      |  P=0.002N**       P=0.500N         P=0.004N**      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  2/47 (4%)        0/44 (0%)        1/47 (2%)       |
|POLY-3 ADJUSTED (b)|                                                        |  4.6%             0.0%             2.8%            |
|TERMINAL (d)       |                                                        |  2/39 (5%)        0/29 (0%)        1/20 (5%)       |
|FIRST INCIDENCE    |                                                        |  735 (T)          ---              735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.686N         P=0.306N         P=0.726N        |
|POLY 3             |                                                        |  P=0.519N         P=0.258N         P=0.567N        |
|POLY 1.5           |                                                        |  P=0.511N         P=0.254N         P=0.539N        |
|POLY 6             |                                                        |  P=0.525N         P=0.267N         P=0.602N        |
|LOGISTIC REGRESSION|                                                        |  P=0.686N         (e)              P=0.726N        |
|COCH-ARM / FISHERS |                                                        |  P=0.496N         P=0.264N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  12/47 (26%)      11/44 (25%)      9/47 (19%)      |
|POLY-3 ADJUSTED (b)|                                                        |  27.0%            26.7%            23.6%           |
|TERMINAL (d)       |                                                        |  11/39 (28%)      7/29 (24%)       2/20 (10%)      |
|FIRST INCIDENCE    |                                                        |  517              589              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.318          P=0.435          P=0.353         |
|POLY 3             |                                                        |  P=0.421N         P=0.586N         P=0.462N        |
|POLY 1.5           |                                                        |  P=0.358N         P=0.574N         P=0.398N        |
|POLY 6             |                                                        |  P=0.500N         P=0.583          P=0.542N        |
|LOGISTIC REGRESSION|                                                        |  P=0.301N         P=0.573N         P=0.360N        |
|COCH-ARM / FISHERS |                                                        |  P=0.266N         P=0.573N         P=0.311N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  0/47 (0%)        1/44 (2%)        2/47 (4%)       |
|POLY-3 ADJUSTED (b)|                                                        |  0.0%             2.5%             5.4%            |
|TERMINAL (d)       |                                                        |  0/39 (0%)        1/29 (3%)        0/20 (0%)       |
|FIRST INCIDENCE    |                                                        |  ---              735 (T)          608             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.103          P=0.441          P=0.185         |
|POLY 3             |                                                        |  P=0.141          P=0.482          P=0.201         |
|POLY 1.5           |                                                        |  P=0.156          P=0.485          P=0.215         |
|POLY 6             |                                                        |  P=0.124          P=0.474          P=0.184         |
|LOGISTIC REGRESSION|                                                        |  P=0.218          P=0.441          P=0.288         |
|COCH-ARM / FISHERS |                                                        |  P=0.180          P=0.484          P=0.247         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        3/50 (6%)        2/49 (4%)        2/47 (4%)     |  1/50 (2%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|        6.5%             4.8%             4.9%          |  2.1%             2.2%             5.2%            |
|TERMINAL (d)       |        2/37 (5%)        1/29 (3%)        1/27 (4%)     |  1/42 (2%)        1/33 (3%)        1/21 (5%)       |
|FIRST INCIDENCE    |        726              681              715           |  735 (T)          735 (T)          650             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.578N         P=0.606N         P=0.634N      |  P=0.209          P=0.707          P=0.304         |
|POLY 3             |        P=0.508N         P=0.544N         P=0.560N      |  P=0.327          P=0.756          P=0.431         |
|POLY 1.5           |        P=0.498N         P=0.530N         P=0.546N      |  P=0.353          P=0.759          P=0.459         |
|POLY 6             |        P=0.522N         P=0.562N         P=0.579N      |  P=0.296          P=0.748          P=0.395         |
|LOGISTIC REGRESSION|        P=0.540N         P=0.571N         P=0.608N      |  P=0.316          P=0.707          P=0.439         |
|COCH-ARM / FISHERS |        P=0.486N         P=0.510N         P=0.530N      |  P=0.393          P=0.753N         P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/49 (0%)        2/47 (4%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             5.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        2/27 (7%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              733 (T)       |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.065          (e)              P=0.172       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.078          (e)              P=0.208       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.080          (e)              P=0.215       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.074          (e)              P=0.199       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.172       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.084          (e)              P=0.232       |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/48 (0%)        1/45 (2%)        0/50 (0%)     |  16/50 (32%)      21/48 (44%)      15/49 (31%)     |
|POLY-3 ADJUSTED (b)|        0.0%             2.6%             0.0%          |  34.0%            47.2%            38.5%           |
|TERMINAL (d)       |        0/36 (0%)        1/27 (4%)        0/27 (0%)     |  15/42 (36%)      18/32 (56%)      9/21 (43%)      |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  678              658              487             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.739N         P=0.443          (e)           |  P=0.041 *        P=0.033 *        P=0.051         |
|POLY 3             |        P=0.714N         P=0.469          (e)           |  P=0.436          P=0.140          P=0.419         |
|POLY 1.5           |        P=0.705N         P=0.476          (e)           |  P=0.550          P=0.155          P=0.512         |
|POLY 6             |        P=0.724N         P=0.460          (e)           |  P=0.304          P=0.113          P=0.309         |
|LOGISTIC REGRESSION|        (e)              P=0.443          (e)           |  P=0.264          P=0.080          P=0.305         |
|COCH-ARM / FISHERS |        P=0.693N         P=0.484          (e)           |  P=0.393N         P=0.161          P=0.527N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Pleura: Mesothelium                                                                                                              |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/0 (0%)         4/4 (100%)       6/6 (100%)    |  0/0 (0%)         3/3 (100%)       13/13 (100%)    |
|POLY-3 ADJUSTED (b)|        0.0%             100.0%           100.0%        |  0.0%             100.0%           100.0%          |
|TERMINAL (d)       |        0/0 (0%)         2/2 (100%)       5/5 (100%)    |  0/0 (0%)         2/2 (100%)       5/5 (100%)      |
|FIRST INCIDENCE    |        ---              664              706           |  ---              681              493             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 3             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|POLY 6             |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        25/50 (50%)      19/50 (38%)      20/49 (41%)   |                                                    |
|POLY-3 ADJUSTED (b)|        53.1%            43.2%            48.9%         |                                                    |
|TERMINAL (d)       |        22/37 (60%)      12/29 (41%)      16/27 (59%)   |                                                    |
|FIRST INCIDENCE    |        607              562              685           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.416          P=0.493N         P=0.439       |                                                    |
|POLY 3             |        P=0.436N         P=0.227N         P=0.426N      |                                                    |
|POLY 1.5           |        P=0.361N         P=0.197N         P=0.340N      |                                                    |
|POLY 6             |        P=0.539N         P=0.265N         P=0.543N      |                                                    |
|LOGISTIC REGRESSION|        P=0.535N         P=0.295N         P=0.585       |                                                    |
|COCH-ARM / FISHERS |        P=0.269N         P=0.157N         P=0.237N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        5/50 (10%)       3/50 (6%)        0/49 (0%)     |                                                    |
|POLY-3 ADJUSTED (b)|        10.8%            7.1%             0.0%          |                                                    |
|TERMINAL (d)       |        5/37 (14%)       2/29 (7%)        0/27 (0%)     |                                                    |
|FIRST INCIDENCE    |        733 (T)          657              ---           |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.052N         P=0.488N         P=0.066N      |                                                    |
|POLY 3             |        P=0.033N*        P=0.403N         P=0.043N*     |                                                    |
|POLY 1.5           |        P=0.030N*        P=0.384N         P=0.038N*     |                                                    |
|POLY 6             |        P=0.038N*        P=0.427N         P=0.049N*     |                                                    |
|LOGISTIC REGRESSION|        P=0.043N*        P=0.451N         (e)           |                                                    |
|COCH-ARM / FISHERS |        P=0.027N*        P=0.357N         P=0.030N*     |                                                    |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        2/50 (4%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        4.3%             4.7%             0.0%          |  0.0%             0.0%             2.6%            |
|TERMINAL (d)       |        2/37 (5%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          682              ---           |  ---              ---              650             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.235N         P=0.603          P=0.310N      |  P=0.234          (e)              P=0.428         |
|POLY 3             |        P=0.194N         P=0.663          P=0.262N      |  P=0.261          (e)              P=0.460         |
|POLY 1.5           |        P=0.185N         P=0.676          P=0.252N      |  P=0.275          (e)              P=0.477         |
|POLY 6             |        P=0.207N         P=0.647          P=0.275N      |  P=0.245          (e)              P=0.440         |
|LOGISTIC REGRESSION|        P=0.205N         P=0.646          (e)           |  P=0.335          (e)              P=0.534         |
|COCH-ARM / FISHERS |        P=0.172N         P=0.691N         P=0.247N      |  P=0.296          (e)              P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        3/50 (6%)        0/50 (0%)     |  0/50 (0%)        0/50 (0%)        1/50 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             7.0%             0.0%          |  0.0%             0.0%             2.6%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              669              ---           |  ---              ---              650             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.566N         P=0.088          (e)           |  P=0.234          (e)              P=0.428         |
|POLY 3             |        P=0.553N         P=0.105          (e)           |  P=0.261          (e)              P=0.460         |
|POLY 1.5           |        P=0.532N         P=0.110          (e)           |  P=0.275          (e)              P=0.477         |
|POLY 6             |        P=0.580N         P=0.099          (e)           |  P=0.245          (e)              P=0.440         |
|LOGISTIC REGRESSION|        P=0.503N         P=0.120          (e)           |  P=0.335          (e)              P=0.534         |
|COCH-ARM / FISHERS |        P=0.500N         P=0.121          (e)           |  P=0.296          (e)              P=0.500         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Prepuce                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/50 (2%)        3/50 (6%)        3/50 (6%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.2%             7.0%             7.1%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/37 (3%)        1/29 (3%)        1/27 (4%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          475              619           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.227          P=0.248          P=0.227       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.260          P=0.280          P=0.272       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.277          P=0.290          P=0.285       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.240          P=0.265          P=0.257       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.343          P=0.373          P=0.305       |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.302          P=0.309          P=0.309       |  (e)              (e)              (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/50 (4%)        0/48 (0%)        0/48 (0%)     |  0/50 (0%)        0/50 (0%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        4.3%             0.0%             0.0%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        1/37 (3%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        662              ---              ---           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.210N         P=0.289N         P=0.301N      |  (e)              (e)              (e)             |
|POLY 3             |        P=0.175N         P=0.265N         P=0.268N      |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.175N         P=0.258N         P=0.259N      |  (e)              (e)              (e)             |
|POLY 6             |        P=0.176N         P=0.276N         P=0.281N      |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.176N         P=0.240N         P=0.242N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.176N         P=0.258N         P=0.258N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        14/50 (28%)      23/48 (48%)      29/48 (60%)   |  16/50 (32%)      26/50 (52%)      21/49 (43%)     |
|POLY-3 ADJUSTED (b)|        29.4%            50.6%            63.8%         |  33.0%            55.2%            47.8%           |
|TERMINAL (d)       |        8/37 (22%)       10/29 (35%)      16/27 (59%)   |  13/42 (31%)      20/33 (61%)      5/21 (24%)      |
|FIRST INCIDENCE    |        607              478              370           |  264              617              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P<0.001 **       P=0.019 *        P<0.001 **    |  P=0.005 **       P=0.006 **       P=0.011 *       |
|POLY 3             |        P<0.001 **       P=0.028 *        P<0.001 **    |  P=0.147          P=0.021 *        P=0.106         |
|POLY 1.5           |        P<0.001 **       P=0.029 *        P<0.001 **    |  P=0.182          P=0.026 *        P=0.129         |
|POLY 6             |        P<0.001 **       P=0.028 *        P<0.001 **    |  P=0.114          P=0.015 *        P=0.084         |
|LOGISTIC REGRESSION|        P=0.003 **       P=0.058          P=0.002 **    |  P=0.343          P=0.034 *        P=0.326         |
|COCH-ARM / FISHERS |        P=0.002 **       P=0.034 *        P<0.001 **    |  P=0.265          P=0.034 *        P=0.182         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        4/48 (8%)        3/48 (6%)     |  15/50 (30%)      11/50 (22%)      14/49 (29%)     |
|POLY-3 ADJUSTED (b)|        0.0%             9.8%             7.4%          |  32.0%            23.9%            36.9%           |
|TERMINAL (d)       |        0/37 (0%)        4/29 (14%)       3/27 (11%)    |  15/42 (36%)      10/33 (30%)      13/21 (62%)     |
|FIRST INCIDENCE    |        ---              733 (T)          733 (T)       |  735 (T)          672              658             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.120          P=0.036 *        P=0.071       |  P=0.021 *        P=0.501N         P=0.026 *       |
|POLY 3             |        P=0.153          P=0.046 *        P=0.097       |  P=0.333          P=0.260N         P=0.406         |
|POLY 1.5           |        P=0.168          P=0.050          P=0.103       |  P=0.419          P=0.248N         P=0.509         |
|POLY 6             |        P=0.135          P=0.042 *        P=0.089       |  P=0.236          P=0.288N         P=0.279         |
|LOGISTIC REGRESSION|        (e)              P=0.036 *        P=0.071       |  P=0.073          P=0.399N         P=0.093         |
|COCH-ARM / FISHERS |        P=0.193          P=0.054          P=0.114       |  P=0.552          P=0.247N         P=0.526N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/49 (0%)        0/48 (0%)        2/50 (4%)     |  0/50 (0%)        2/50 (4%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             4.7%          |  0.0%             4.3%             0.0%            |
|TERMINAL (d)       |        0/36 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        ---              ---              562           |  ---              658              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.086          (e)              P=0.223       |  P=0.673N         P=0.229          (e)             |
|POLY 3             |        P=0.087          (e)              P=0.223       |  P=0.649N         P=0.235          (e)             |
|POLY 1.5           |        P=0.090          (e)              P=0.231       |  P=0.619N         P=0.237          (e)             |
|POLY 6             |        P=0.084          (e)              P=0.215       |  P=0.687N         P=0.229          (e)             |
|LOGISTIC REGRESSION|        P=0.160          (e)              P=0.424       |  P=0.542N         P=0.214          (e)             |
|COCH-ARM / FISHERS |        P=0.095          (e)              P=0.253       |  P=0.575N         P=0.247          (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/49 (2%)        3/48 (6%)        1/50 (2%)     |  0/50 (0%)        0/50 (0%)        0/50 (0%)       |
|POLY-3 ADJUSTED (b)|        2.2%             7.1%             2.4%          |  0.0%             0.0%             0.0%            |
|TERMINAL (d)       |        0/36 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |        664              481              668           |  ---              ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.608N         P=0.265          P=0.715       |  (e)              (e)              (e)             |
|POLY 3             |        P=0.586N         P=0.280          P=0.741       |  (e)              (e)              (e)             |
|POLY 1.5           |        P=0.567N         P=0.287          P=0.751       |  (e)              (e)              (e)             |
|POLY 6             |        P=0.610N         P=0.272          P=0.729       |  (e)              (e)              (e)             |
|LOGISTIC REGRESSION|        P=0.385N         P=0.507          P=0.726N      |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.538N         P=0.301          P=0.747N      |  (e)              (e)              (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        2/49 (4%)        8/48 (17%)       5/50 (10%)    |  1/50 (2%)        4/50 (8%)        3/50 (6%)       |
|POLY-3 ADJUSTED (b)|        4.4%             18.2%            11.6%         |  2.1%             8.6%             7.6%            |
|TERMINAL (d)       |        0/36 (0%)        2/29 (7%)        1/27 (4%)     |  1/42 (2%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        664              475              562           |  735 (T)          658              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.245          P=0.036 *        P=0.155       |  P=0.185          P=0.144          P=0.194         |
|POLY 3             |        P=0.285          P=0.039 *        P=0.194       |  P=0.253          P=0.176          P=0.246         |
|POLY 1.5           |        P=0.308          P=0.041 *        P=0.206       |  P=0.291          P=0.180          P=0.270         |
|POLY 6             |        P=0.259          P=0.038 *        P=0.181       |  P=0.208          P=0.169          P=0.217         |
|LOGISTIC REGRESSION|        P=0.583          P=0.129          P=0.328       |  P=0.474          P=0.176          P=0.412         |
|COCH-ARM / FISHERS |        P=0.348          P=0.042 *        P=0.226       |  P=0.349          P=0.181          P=0.309         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        1/49 (2%)        2/48 (4%)        2/47 (4%)     |  2/49 (4%)        1/50 (2%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        2.2%             4.8%             5.0%          |  4.3%             2.2%             2.6%            |
|TERMINAL (d)       |        1/36 (3%)        0/29 (0%)        1/27 (4%)     |  2/42 (5%)        1/33 (3%)        0/21 (0%)       |
|FIRST INCIDENCE    |        733 (T)          625              727           |  735 (T)          735 (T)          578             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.367          P=0.454          P=0.402       |  P=0.628N         P=0.584N         P=0.674N        |
|POLY 3             |        P=0.407          P=0.472          P=0.461       |  P=0.493N         P=0.503N         P=0.566N        |
|POLY 1.5           |        P=0.420          P=0.480          P=0.472       |  P=0.476N         P=0.496N         P=0.539N        |
|POLY 6             |        P=0.388          P=0.464          P=0.447       |  P=0.515N         P=0.517N         P=0.600N        |
|LOGISTIC REGRESSION|        P=0.440          P=0.557          P=0.416       |  P=0.449N         P=0.584N         P=0.494N        |
|COCH-ARM / FISHERS |        P=0.436          P=0.492          P=0.484       |  P=0.447N         P=0.492N         P=0.500N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        6/50 (12%)       2/50 (4%)        2/50 (4%)     |                                                    |
|POLY-3 ADJUSTED (b)|        12.8%            4.7%             4.8%          |                                                    |
|TERMINAL (d)       |        4/37 (11%)       1/29 (3%)        2/27 (7%)     |                                                    |
|FIRST INCIDENCE    |        615              650              733 (T)       |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.217N         P=0.218N         P=0.246N      |                                                    |
|POLY 3             |        P=0.148N         P=0.166N         P=0.175N      |                                                    |
|POLY 1.5           |        P=0.139N         P=0.152N         P=0.157N      |                                                    |
|POLY 6             |        P=0.162N         P=0.185N         P=0.201N      |                                                    |
|LOGISTIC REGRESSION|        P=0.154N         P=0.139N         P=0.171N      |                                                    |
|COCH-ARM / FISHERS |        P=0.128N         P=0.134N         P=0.134N      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        1/50 (2%)        2/50 (4%)     |                                                    |
|POLY-3 ADJUSTED (b)|        0.0%             2.4%             4.8%          |                                                    |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        2/27 (7%)     |                                                    |
|FIRST INCIDENCE    |        ---              672              733 (T)       |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.130          P=0.468          P=0.172       |                                                    |
|POLY 3             |        P=0.151          P=0.483          P=0.214       |                                                    |
|POLY 1.5           |        P=0.161          P=0.490          P=0.223       |                                                    |
|POLY 6             |        P=0.139          P=0.474          P=0.202       |                                                    |
|LOGISTIC REGRESSION|        P=0.151          P=0.535          P=0.172       |                                                    |
|COCH-ARM / FISHERS |        P=0.175          P=0.500          P=0.247       |                                                    |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/35 (0%)        0/41 (0%)        0/35 (0%)     |  0/47 (0%)        3/42 (7%)        2/42 (5%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             7.7%             6.3%            |
|TERMINAL (d)       |        0/28 (0%)        0/27 (0%)        0/19 (0%)     |  0/40 (0%)        3/29 (10%)       2/20 (10%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.118          P=0.071          P=0.104         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.181          P=0.095          P=0.168         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.216          P=0.097          P=0.184         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.145          P=0.091          P=0.152         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              P=0.071          P=0.104         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.281          P=0.101          P=0.220         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/47 (0%)        0/47 (0%)        0/50 (0%)     |  0/50 (0%)        4/50 (8%)        1/49 (2%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  0.0%             8.7%             2.7%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  0/42 (0%)        4/33 (12%)       1/20 (5%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  ---              735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.328          P=0.037 *        P=0.352         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.449          P=0.058          P=0.453         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.509          P=0.060          P=0.471         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.372          P=0.053          P=0.431         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              P=0.037 *        P=0.352         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.588          P=0.059          P=0.495         |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/47 (0%)        0/47 (0%)        0/50 (0%)     |  1/50 (2%)        2/50 (4%)        0/49 (0%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  2.1%             4.3%             0.0%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  1/42 (2%)        1/33 (3%)        0/20 (0%)       |
|FIRST INCIDENCE    |        ---              ---              ---           |  735 (T)          687              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.484N         P=0.433          P=0.648N        |
|POLY 3             |        (e)              (e)              (e)           |  P=0.395N         P=0.494          P=0.546N        |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.366N         P=0.499          P=0.529N        |
|POLY 6             |        (e)              (e)              (e)           |  P=0.434N         P=0.483          P=0.569N        |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.397N         P=0.496          (e)             |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.325N         P=0.500          P=0.505N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/0 (0%)         1/1 (100%)       0/2 (0%)      |  0/1 (0%)         2/2 (100%)       0/0 (0%)        |
|POLY-3 ADJUSTED (b)|        0.0%             100.0%           0.0%          |  0.0%             100.0%           0.0%            |
|TERMINAL (d)       |        0/0 (0%)         1/1 (100%)       0/2 (0%)      |  0/1 (0%)         1/1 (100%)       0/0 (0%)        |
|FIRST INCIDENCE    |        ---              733 (T)          ---           |  ---              687              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.362N         (e)              (e)           |  P=0.656          P=0.217          (e)             |
|POLY 3             |        (e)              (e)              (e)           |  (e)              P=1.000N         (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  (e)              P=1.000N         (e)             |
|POLY 6             |        (e)              (e)              (e)           |  (e)              P=1.000N         (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  (e)              (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.333N         (e)              (e)           |  P=0.807          P=0.333          (e)             |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Malformation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/0 (0%)         0/1 (0%)         2/2 (100%)    |  1/1 (100%)       0/2 (0%)         0/0 (0%)        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             100.0%        |  100.0%           0.0%             0.0%            |
|TERMINAL (d)       |        0/0 (0%)         0/1 (0%)         2/2 (100%)    |  1/1 (100%)       0/1 (0%)         0/0 (0%)        |
|FIRST INCIDENCE    |        ---              ---              733 (T)       |  735 (T)          ---              ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        P=0.362          (e)              (e)           |  P=0.841N         P=0.500N         (e)             |
|POLY 3             |        (e)              (e)              (e)           |  (e)              P<0.001N**       (e)             |
|POLY 1.5           |        (e)              (e)              (e)           |  (e)              P<0.001N**       (e)             |
|POLY 6             |        (e)              (e)              (e)           |  (e)              P=0.042N*        (e)             |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.841N         (e)              (e)             |
|COCH-ARM / FISHERS |        P=0.333          (e)              (e)           |  P=0.807N         P=0.333N         (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |        0/50 (0%)        0/48 (0%)        0/47 (0%)     |  2/48 (4%)        3/49 (6%)        2/48 (4%)       |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%          |  4.4%             6.7%             5.4%            |
|TERMINAL (d)       |        0/37 (0%)        0/29 (0%)        0/27 (0%)     |  2/42 (5%)        3/33 (9%)        2/21 (10%)      |
|FIRST INCIDENCE    |        ---              ---              ---           |  735 (T)          735 (T)          735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |        (e)              (e)              (e)           |  P=0.367          P=0.391          P=0.428         |
|POLY 3             |        (e)              (e)              (e)           |  P=0.553          P=0.492          P=0.617         |
|POLY 1.5           |        (e)              (e)              (e)           |  P=0.597          P=0.502          P=0.650         |
|POLY 6             |        (e)              (e)              (e)           |  P=0.495          P=0.473          P=0.573         |
|LOGISTIC REGRESSION|        (e)              (e)              (e)           |  P=0.367          P=0.391          P=0.428         |
|COCH-ARM / FISHERS |        (e)              (e)              (e)           |  P=0.584N         P=0.510          P=0.692N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  1/50 (2%)        3/50 (6%)        5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                                                        |  2.1%             6.5%             12.5%           |
|TERMINAL (d)       |                                                        |  1/42 (2%)        2/33 (6%)        1/21 (5%)       |
|FIRST INCIDENCE    |                                                        |  735 (T)          672              510             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.023 *        P=0.243          P=0.044 *       |
|POLY 3             |                                                        |  P=0.053          P=0.299          P=0.069         |
|POLY 1.5           |                                                        |  P=0.064          P=0.305          P=0.081         |
|POLY 6             |                                                        |  P=0.041 *        P=0.289          P=0.056         |
|LOGISTIC REGRESSION|                                                        |  P=0.128          P=0.300          P=0.149         |
|COCH-ARM / FISHERS |                                                        |  P=0.084          P=0.309          P=0.102         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  8/50 (16%)       8/50 (16%)       5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                                                        |  16.8%            17.2%            12.6%           |
|TERMINAL (d)       |                                                        |  6/42 (14%)       7/33 (21%)       2/21 (10%)      |
|FIRST INCIDENCE    |                                                        |  626              547              487             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.522          P=0.440          P=0.587         |
|POLY 3             |                                                        |  P=0.352N         P=0.588          P=0.401N        |
|POLY 1.5           |                                                        |  P=0.298N         P=0.603          P=0.347N        |
|POLY 6             |                                                        |  P=0.427N         P=0.556          P=0.476N        |
|LOGISTIC REGRESSION|                                                        |  P=0.204N         P=0.607N         P=0.247N        |
|COCH-ARM / FISHERS |                                                        |  P=0.225N         P=0.607N         P=0.277N        |
|=================================================================================================================================|
       Date:  02/22/00                           EXPERIMENT: 88124 TEST: 04                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  INDIUM PHOSPHIDE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  38/50 (76%)      36/50 (72%)      32/50 (64%)     |
|POLY-3 ADJUSTED (b)|                                                        |  80.6%            76.0%            74.1%           |
|TERMINAL (d)       |                                                        |  36/42 (86%)      27/33 (82%)      18/21 (86%)     |
|FIRST INCIDENCE    |                                                        |  678              617              421             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P<0.001 **       P=0.127          P=0.002 **      |
|POLY 3             |                                                        |  P=0.285N         P=0.380N         P=0.299N        |
|POLY 1.5           |                                                        |  P=0.203N         P=0.373N         P=0.217N        |
|POLY 6             |                                                        |  P=0.415N         P=0.419N         P=0.438N        |
|LOGISTIC REGRESSION|                                                        |  P=0.419          P=0.568          P=0.589         |
|COCH-ARM / FISHERS |                                                        |  P=0.115N         P=0.410N         P=0.138N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |        CONTROL          0.1MG/M3         0.3MG/M3      |  CONTROL          0.1MG/M3         0.3MG/M3        |
|                   |                          STOP             STOP         |                    STOP             STOP           |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |  0/50 (0%)        1/50 (2%)        2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                                                        |  0.0%             2.2%             5.1%            |
|TERMINAL (d)       |                                                        |  0/42 (0%)        0/33 (0%)        0/21 (0%)       |
|FIRST INCIDENCE    |                                                        |  ---              729              510             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |  P=0.118          P=0.458          P=0.211         |
|POLY 3             |                                                        |  P=0.136          P=0.496          P=0.200         |
|POLY 1.5           |                                                        |  P=0.151          P=0.499          P=0.215         |
|POLY 6             |                                                        |  P=0.119          P=0.489          P=0.182         |
|LOGISTIC REGRESSION|                                                        |  P=0.284          P=0.482          P=0.345         |
|COCH-ARM / FISHERS |                                                        |  P=0.175          P=0.500          P=0.247         |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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