https://ntp.niehs.nih.gov/go/4485

TDMS Study 88127-04 Pathology Tables

NTP Experiment-Test: 88127-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                            PENTAERYTHRITOL TRIACRYLATE                                Date: 12/08/99
Route: SKIN APPLICATION                                                                                           Time: 08:50:27
                                                       13 WEEK SUBCHRONIC
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  3524-68-3
       Lock Date:  10/09/97
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88127-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                            PENTAERYTHRITOL TRIACRYLATE                                Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:50:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1                                                                            
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            9           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)                      (1)                                    (10)         
      Hepatodiaphragmatic Nodule                                                 1 (100%)                                           
      Inflammation, Chronic Active                     1 (10%)                                                          1 (10%)     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)                                                             (10)         
      Accessory Adrenal Cortical Nodule                1 (10%)                                                                      
      Vacuolization Cytoplasmic                        6 (60%)                                                          7 (70%)     
      Subcapsular, Hyperplasia                         8 (80%)                                                          7 (70%)     
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (10)                                                (1)          (9)          
      Inflammation, Chronic Active                                                                         1 (100%)     1 (11%)     
   Uterus                                             (10)                                                             (9)          
      Hydrometra                                                                                                        1 (11%)     
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88127-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                            PENTAERYTHRITOL TRIACRYLATE                                Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:50:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (9)          (10)         (10)         (10)         (10)         (10)         
      Dermis, Skin, Site of Application, Fibrosis                                                          9 (90%)     10 (100%)    
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation, Chronic Active                              2 (20%)      5 (50%)      9 (90%)      9 (90%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                               1 (10%)      2 (20%)      6 (60%)      8 (80%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                                                         2 (20%)      3 (30%)     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                                           9 (90%)      9 (90%)      8 (80%)     10 (100%)    
      Skin, Site of Application, Hyperkeratosis                     1 (10%)      2 (20%)      7 (70%)      7 (70%)      7 (70%)     
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)                                                             (10)         
      Nephropathy                                      3 (30%)                                                                      
   Urinary Bladder                                    (10)                                                             (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88127-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                            PENTAERYTHRITOL TRIACRYLATE                                Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:50:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT                                                                                                               
      Edema                                            1 (10%)                                                          2 (20%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88127-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                            PENTAERYTHRITOL TRIACRYLATE                                Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:50:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)                                                             (10)         
      Inflammation, Chronic Active                                                                                      1 (10%)     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)                                                             (10)         
      Subcapsular, Hyperplasia                         1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Hyperkeratosis                                                                                       1 (10%)                  
      Dermis, Skin, Site of Application, Fibrosis                                                          6 (60%)     10 (100%)    
      Dermis, Skin, Site of Application,                                                                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88127-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                            PENTAERYTHRITOL TRIACRYLATE                                Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:50:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT                                                                                                         
          Inflammation, Chronic Active                                           8 (80%)      8 (80%)     10 (100%)    10 (100%)    
      Epidermis, Hyperplasia                                                                               1 (10%)                  
      Epidermis, Inflammation, Suppurative                                                                 1 (10%)                  
      Epidermis, Skin, Site of Application,                                                                                         
          Degeneration                                                           5 (50%)      5 (50%)      2 (20%)      4 (40%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                            3 (30%)      8 (80%)      9 (90%)     10 (100%)    
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation, Suppurative                                                           2 (20%)                               
      Epidermis, Skin, Site of Application,                                                                                         
          Necrosis                                                               2 (20%)      3 (30%)      7 (70%)      7 (70%)     
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                                           7 (70%)      9 (90%)     10 (100%)    10 (100%)    
      Skin, Site of Application, Hyperkeratosis                                  5 (50%)      7 (70%)      8 (80%)      6 (60%)     
      Skin, Site of Application, Necrosis                                                                  1 (10%)                  
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)                                                             (10)         
      Nephropathy                                      1 (10%)                                                                      
   Urinary Bladder                                    (10)                                                             (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88127-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                            PENTAERYTHRITOL TRIACRYLATE                                Date: 12/08/99  
Route: SKIN APPLICATION                                                                                           Time: 08:50:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      0.75         1.5          3 MG/KG      6 MG/KG      12 MG/KG        
                                                                MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT                                                                                                               
      Edema                                                                                                             1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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