National Toxicology Program

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TDMS Study 88127-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                             PENTAERYTHRITOL TRIACRYLATE (PETA)                          DATE: 07/12/02       
EXPERIMENT: 88127 TEST: 06                                                                                     TIME: 08:40:32       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                   PAGE:       1        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88127B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 3524-68-3       
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                                                              Final#2                                                               
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                             PENTAERYTHRITOL TRIACRYLATE (PETA)                          DATE: 07/12/02       
EXPERIMENT: 88127 TEST: 06                                                                                     TIME: 08:40:32       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                                        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88127B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 3524-68-3       
Mice(TG.AC HETEROZYGOUS TRANSGENIC)                                                                                                 
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Medulla                                                                    
                                                 Lung                                                                               
                                                 Salivary Glands                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                             PENTAERYTHRITOL TRIACRYLATE (PETA)                          DATE: 07/12/02       
EXPERIMENT: 88127 TEST: 06                                                                                     TIME: 08:40:32       
TEST TYPE:  SUBCHRON 26-WEEK                                                                                                        
CONT: NO1-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 88127B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 3524-68-3       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF        PENTAERYTHRITOL TRIACRYLATE (PETA)                                                                        
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Skin                                                                                                                                
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom                                                                                                                 
                                       Squamous Cell Carcinoma                                                                      
                                       Squamous Cell Papilloma                                                                      
                                       Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma               
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Skin                                                                                                                                
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom                                                                                                                 
                                       Squamous Cell Papilloma                                                                      
                                       Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma               
Tooth                                  Odontogenic Tumor                                                                            
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 1       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)        -         PENTAERYTHRITOL TRIACRYLATE (PETA)   
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       1/15 (7%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        2/13.95          1/14.34          0/15.00          0/15.00          0/14.39          0/13.53         | 
|POLY-3 PERCENT (g) |        14.3%            7.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        1/12 (8%)        1/14 (7%)        0/15 (0%)        0/15 (0%)        0/12 (0%)        0/10 (0%)       | 
|FIRST INCIDENCE    |        145              185 (T)          ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.146N         P=0.464N         P=0.208N         P=0.208N         P=0.232N         P=0.260N        | 
|POLY 3             |        P=0.133N         P=0.490N         P=0.215N         P=0.215N         P=0.224N         P=0.238N        | 
|POLY 1.5           |        P=0.132N         P=0.495N         P=0.221N         P=0.221N         P=0.226N         P=0.234N        | 
|POLY 6             |        P=0.135N         P=0.484N         P=0.207N         P=0.207N         P=0.222N         P=0.245N        | 
|LOGISTIC REGRESSION|        P=0.139N         P=0.542N         P=0.416N         P=0.416N         P=0.347N         P=0.252N        | 
|COCH-ARM / FISHERS |        P=0.131N         P=0.500N         P=0.241N         P=0.241N         P=0.241N         P=0.241N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 2       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        4/15 (27%)       15/15 (100%)     15/15 (100%)     13/15 (87%)     | 
|POLY-3 RATE (b)    |        1/13.43          0/14.34          4/15.00          15/15.00         15/15.00         13/15.00        | 
|POLY-3 PERCENT (g) |        7.4%             0.0%             26.7%            100.0%           100.0%           86.7%           | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        4/15 (27%)       15/15 (100%)     12/12 (100%)     8/10 (80%)      | 
|FIRST INCIDENCE    |        185 (T)          ---              185 (T)          185 (T)          163              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.469N         P=0.240          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.487N         P=0.198          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.493N         P=0.183          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.479N         P=0.218          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.240          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.165          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        10/15 (67%)      12/15 (80%)      13/15 (87%)     | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          1/12.72          10/14.63         12/14.10         13/14.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.9%             68.4%            85.1%            92.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        1/12 (8%)        9/12 (75%)       11/13 (85%)      8/9 (89%)       | 
|FIRST INCIDENCE    |        ---              ---              186 (T)          177              182              98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.496          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.497          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.493          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 3       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        2/15 (13%)       0/15 (0%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        0/13.43          0/14.34          0/15.00          2/15.00          0/14.39          3/13.57         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             13.3%            0.0%             22.1%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/15 (0%)        2/15 (13%)       0/12 (0%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        ---              ---              ---              185 (T)          ---              182             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.005 **       (e)              (e)              P=0.286          (e)              P=0.095         | 
|POLY 3             |        P=0.011 *        (e)              (e)              P=0.257          (e)              P=0.106         | 
|POLY 1.5           |        P=0.011 *        (e)              (e)              P=0.246          (e)              P=0.106         | 
|POLY 6             |        P=0.010 *        (e)              (e)              P=0.271          (e)              P=0.103         | 
|LOGISTIC REGRESSION|        P=0.007 **       (e)              (e)              P=0.286          (e)              P=0.100         | 
|COCH-ARM / FISHERS |        P=0.014 *        (e)              (e)              P=0.241          (e)              P=0.112         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        0/15 (0%)        1/15 (7%)       | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          0/12.72          0/14.49          0/14.03          1/10.72         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             9.3%            | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.073          (e)              (e)              (e)              (e)              P=0.443         | 
|POLY 3             |        P=0.090          (e)              (e)              (e)              (e)              P=0.462         | 
|POLY 1.5           |        P=0.095          (e)              (e)              (e)              (e)              P=0.477         | 
|POLY 6             |        P=0.085          (e)              (e)              (e)              (e)              P=0.447         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.443         | 
|COCH-ARM / FISHERS |        P=0.105          (e)              (e)              (e)              (e)              P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 4       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        4/15 (27%)       15/15 (100%)     15/15 (100%)     13/15 (87%)     | 
|POLY-3 RATE (b)    |        1/13.43          0/14.34          4/15.00          15/15.00         15/15.00         13/15.00        | 
|POLY-3 PERCENT (g) |        7.4%             0.0%             26.7%            100.0%           100.0%           86.7%           | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        4/15 (27%)       15/15 (100%)     12/12 (100%)     8/10 (80%)      | 
|FIRST INCIDENCE    |        185 (T)          ---              185 (T)          185 (T)          163              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.469N         P=0.240          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.487N         P=0.198          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.493N         P=0.183          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.479N         P=0.218          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.240          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.165          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        10/15 (67%)      12/15 (80%)      13/15 (87%)     | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          1/12.72          10/14.63         12/14.10         13/14.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.9%             68.4%            85.1%            92.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        1/12 (8%)        9/12 (75%)       11/13 (85%)      8/9 (89%)       | 
|FIRST INCIDENCE    |        ---              ---              186 (T)          177              182              98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.496          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.497          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.493          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 5       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        4/15 (27%)       15/15 (100%)     15/15 (100%)     13/15 (87%)     | 
|POLY-3 RATE (b)    |        1/13.43          0/14.34          4/15.00          15/15.00         15/15.00         13/15.00        | 
|POLY-3 PERCENT (g) |        7.4%             0.0%             26.7%            100.0%           100.0%           86.7%           | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        4/15 (27%)       15/15 (100%)     12/12 (100%)     8/10 (80%)      | 
|FIRST INCIDENCE    |        185 (T)          ---              185 (T)          185 (T)          163              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.469N         P=0.240          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.487N         P=0.198          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.493N         P=0.183          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.479N         P=0.218          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.240          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.165          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/15 (0%)        0/15 (0%)        1/15 (7%)        10/15 (67%)      12/15 (80%)      13/15 (87%)     | 
|POLY-3 RATE (b)    |        0/12.95          0/14.05          1/12.72          10/14.63         12/14.10         13/14.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.9%             68.4%            85.1%            92.8%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        1/12 (8%)        9/12 (75%)       11/13 (85%)      8/9 (89%)       | 
|FIRST INCIDENCE    |        ---              ---              186 (T)          177              182              98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P=0.496          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.497          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P=0.493          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P<0.001 **       P<0.001 **       P<0.001 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 6       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/15 (40%)       4/15 (27%)       5/15 (33%)       8/15 (53%)       5/15 (33%)       5/15 (33%)      | 
|POLY-3 RATE (b)    |        6/13.95          4/15.00          5/15.00          8/15.00          5/14.39          5/13.53         | 
|POLY-3 PERCENT (g) |        43.0%            26.7%            33.3%            53.3%            34.8%            37.0%           | 
|TERMINAL (d)       |        5/12 (42%)       3/14 (21%)       5/15 (33%)       8/15 (53%)       5/12 (42%)       5/10 (50%)      | 
|FIRST INCIDENCE    |        145              129              185 (T)          185 (T)          185 (T)          185 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.356          P=0.281N         P=0.337N         P=0.568          P=0.495N         P=0.638N        | 
|POLY 3             |        P=0.550          P=0.300N         P=0.441N         P=0.429          P=0.474N         P=0.526N        | 
|POLY 1.5           |        P=0.534N         P=0.321N         P=0.465N         P=0.400          P=0.483N         P=0.512N        | 
|POLY 6             |        P=0.490          P=0.277N         P=0.413N         P=0.463          P=0.471N         P=0.555N        | 
|LOGISTIC REGRESSION|        P=0.508N         P=0.394N         P=0.479N         P=0.415          P=0.454N         P=0.495N        | 
|COCH-ARM / FISHERS |        P=0.492N         P=0.350N         P=0.500N         P=0.358          P=0.500N         P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/15 (33%)       4/15 (27%)       5/15 (33%)       7/15 (47%)       7/15 (47%)       4/15 (27%)      | 
|POLY-3 RATE (b)    |        5/12.95          4/14.05          5/12.72          7/14.49          7/14.94          4/10.72         | 
|POLY-3 PERCENT (g) |        38.6%            28.5%            39.3%            48.3%            46.9%            37.3%           | 
|TERMINAL (d)       |        5/12 (42%)       4/14 (29%)       5/12 (42%)       7/12 (58%)       6/13 (46%)       4/9 (44%)       | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          186 (T)          186 (T)          85               186 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.343          P=0.389N         P=0.657          P=0.345          P=0.429          P=0.622         | 
|POLY 3             |        P=0.409          P=0.442N         P=0.640          P=0.451          P=0.478          P=0.637N        | 
|POLY 1.5           |        P=0.481          P=0.456N         P=0.642          P=0.439          P=0.453          P=0.584N        | 
|POLY 6             |        P=0.342          P=0.433N         P=0.628          P=0.439          P=0.489          P=0.630         | 
|LOGISTIC REGRESSION|        P=0.457          P=0.389N         P=0.657          P=0.345          P=0.376          P=0.622         | 
|COCH-ARM / FISHERS |        P=0.511N         P=0.500N         P=0.650N         P=0.355          P=0.355          P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 7       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Odontogenic Tumor                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/15 (13%)       0/15 (0%)        3/15 (20%)       1/15 (7%)        3/15 (20%)       2/15 (13%)      | 
|POLY-3 RATE (b)    |        2/13.85          0/14.34          3/15.00          1/15.00          3/14.41          2/13.75         | 
|POLY-3 PERCENT (g) |        14.5%            0.0%             20.0%            6.7%             20.8%            14.6%           | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        3/15 (20%)       1/15 (7%)        2/12 (17%)       1/10 (10%)      | 
|FIRST INCIDENCE    |        155              ---              185 (T)          185 (T)          184              170             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.265          P=0.215N         P=0.596          P=0.431N         P=0.520          P=0.668         | 
|POLY 3             |        P=0.358          P=0.223N         P=0.538          P=0.472N         P=0.519          P=0.697         | 
|POLY 1.5           |        P=0.370          P=0.226N         P=0.523          P=0.483N         P=0.513          P=0.699         | 
|POLY 6             |        P=0.338          P=0.218N         P=0.555          P=0.459N         P=0.522          P=0.692         | 
|LOGISTIC REGRESSION|        P=0.385          P=0.258N         P=0.449          P=0.620N         P=0.489          P=0.697         | 
|COCH-ARM / FISHERS |        P=0.381          P=0.241N         P=0.500          P=0.500N         P=0.500          P=0.701N        | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Odontogenic Tumor                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/15 (27%)       0/15 (0%)        3/15 (20%)       2/15 (13%)       1/15 (7%)        0/15 (0%)       | 
|POLY-3 RATE (b)    |        4/13.09          0/14.05          3/12.72          2/14.91          1/14.03          0/10.72         | 
|POLY-3 PERCENT (g) |        30.6%            0.0%             23.6%            13.4%            7.1%             0.0%            | 
|TERMINAL (d)       |        3/12 (25%)       0/14 (0%)        3/12 (25%)       0/12 (0%)        1/13 (8%)        0/9 (0%)        | 
|FIRST INCIDENCE    |        177              ---              186 (T)          167              186 (T)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.094N         P=0.046N*        P=0.507N         P=0.315N         P=0.150N         P=0.104N        | 
|POLY 3             |        P=0.077N         P=0.036N*        P=0.518N         P=0.264N         P=0.139N         P=0.070N        | 
|POLY 1.5           |        P=0.070N         P=0.037N*        P=0.512N         P=0.275N         P=0.141N         P=0.058N        | 
|POLY 6             |        P=0.085N         P=0.036N*        P=0.533N         P=0.264N         P=0.140N         P=0.086N        | 
|LOGISTIC REGRESSION|        P=0.069N         P=0.044N*        P=0.519N         P=0.296N         P=0.139N         P=0.081N        | 
|COCH-ARM / FISHERS |        P=0.058N         P=0.050N         P=0.500N         P=0.326N         P=0.165N         P=0.050N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 8       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/15 (47%)       5/15 (33%)       8/15 (53%)       15/15 (100%)     15/15 (100%)     13/15 (87%)     | 
|POLY-3 RATE (b)    |        7/13.95          5/15.00          8/15.00          15/15.00         15/15.00         13/15.00        | 
|POLY-3 PERCENT (g) |        50.2%            33.3%            53.3%            100.0%           100.0%           86.7%           | 
|TERMINAL (d)       |        6/12 (50%)       4/14 (29%)       8/15 (53%)       15/15 (100%)     12/12 (100%)     8/10 (80%)      | 
|FIRST INCIDENCE    |        145              129              185 (T)          185 (T)          163              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.270N         P=0.558N         P=0.027 *        P=0.011 *        P=0.033 *       | 
|POLY 3             |        P<0.001 **       P=0.297N         P=0.578          P<0.001 **       P<0.001 **       P=0.033 *       | 
|POLY 1.5           |        P<0.001 **       P=0.321N         P=0.546          P<0.001 **       P<0.001 **       P=0.026 *       | 
|POLY 6             |        P<0.001 **       P=0.270N         P=0.615          P<0.001 **       P<0.001 **       P=0.045 *       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.384N         P=0.585          P=0.004 **       P=0.003 **       P=0.027 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.355N         P=0.500          P<0.001 **       P<0.001 **       P=0.025 *       | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/15 (33%)       4/15 (27%)       6/15 (40%)       11/15 (73%)      13/15 (87%)      13/15 (87%)     | 
|POLY-3 RATE (b)    |        5/12.95          4/14.05          6/12.72          11/14.63         13/15.00         13/14.00        | 
|POLY-3 PERCENT (g) |        38.6%            28.5%            47.2%            75.2%            86.7%            92.8%           | 
|TERMINAL (d)       |        5/12 (42%)       4/14 (29%)       6/12 (50%)       10/12 (83%)      11/13 (85%)      8/9 (89%)       | 
|FIRST INCIDENCE    |        186 (T)          186 (T)          186 (T)          177              85               98              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.389N         P=0.500          P=0.029 *        P=0.014 *        P=0.002 **      | 
|POLY 3             |        P<0.001 **       P=0.442N         P=0.484          P=0.052          P=0.006 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.456N         P=0.488          P=0.047 *        P=0.004 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.433N         P=0.470          P=0.048 *        P=0.008 **       P=0.002 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.389N         P=0.500          P=0.035 *        P=0.006 **       P=0.002 **      | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.500          P=0.033 *        P=0.004 **       P=0.004 **      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 9       
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        1/15 (7%)        0/15 (0%)        3/15 (20%)       0/15 (0%)        5/15 (33%)      | 
|POLY-3 RATE (b)    |        1/13.43          1/15.00          0/15.00          3/15.00          0/14.39          5/14.42         | 
|POLY-3 PERCENT (g) |        7.4%             6.7%             0.0%             20.0%            0.0%             34.7%           | 
|TERMINAL (d)       |        1/12 (8%)        0/14 (0%)        0/15 (0%)        3/15 (20%)       0/12 (0%)        2/10 (20%)      | 
|FIRST INCIDENCE    |        185 (T)          129              ---              185 (T)          ---              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.005 **       P=0.743N         P=0.455N         P=0.383          P=0.500N         P=0.087         | 
|POLY 3             |        P=0.008 **       P=0.736N         P=0.478N         P=0.340          P=0.486N         P=0.094         | 
|POLY 1.5           |        P=0.008 **       P=0.746N         P=0.487N         P=0.322          P=0.492N         P=0.088         | 
|POLY 6             |        P=0.008 **       P=0.723N         P=0.467N         P=0.362          P=0.481N         P=0.100         | 
|LOGISTIC REGRESSION|        P=0.015 *        P=0.722          (e)              P=0.383          (e)              P=0.079         | 
|COCH-ARM / FISHERS |        P=0.011 *        P=0.759N         P=0.500N         P=0.299          P=0.500N         P=0.084         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/15 (7%)        0/15 (0%)        0/15 (0%)        1/15 (7%)        0/15 (0%)        3/15 (20%)      | 
|POLY-3 RATE (b)    |        1/13.90          0/14.05          0/12.72          1/14.59          0/14.03          3/12.41         | 
|POLY-3 PERCENT (g) |        7.2%             0.0%             0.0%             6.9%             0.0%             24.2%           | 
|TERMINAL (d)       |        0/12 (0%)        0/14 (0%)        0/12 (0%)        0/12 (0%)        0/13 (0%)        1/9 (11%)       | 
|FIRST INCIDENCE    |        70               ---              ---              180              ---              27              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.024 *        P=0.500N         P=0.500N         P=0.744N         P=0.486N         P=0.277         | 
|POLY 3             |        P=0.028 *        P=0.498N         P=0.518N         P=0.750N         P=0.498N         P=0.254         | 
|POLY 1.5           |        P=0.029 *        P=0.499N         P=0.514N         P=0.751N         P=0.498N         P=0.273         | 
|POLY 6             |        P=0.027 *        P=0.496N         P=0.522N         P=0.753N         P=0.498N         P=0.236         | 
|LOGISTIC REGRESSION|        P=0.064          P=0.665N         P=0.403N         P=0.538          P=0.890N         P=0.382         | 
|COCH-ARM / FISHERS |        P=0.032 *        P=0.500N         P=0.500N         P=0.759N         P=0.500N         P=0.299         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/12/02                           EXPERIMENT: 88127 TEST: 06                                            Page 10      
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC)       -         PENTAERYTHRITOL TRIACRYLATE (PETA)    
                                         Terminal Sacrifice at 27 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/15 (60%)       5/15 (33%)       9/15 (60%)       15/15 (100%)     15/15 (100%)     13/15 (87%)     | 
|POLY-3 RATE (b)    |        9/14.36          5/15.00          9/15.00          15/15.00         15/15.00         13/15.00        | 
|POLY-3 PERCENT (g) |        62.7%            33.3%            60.0%            100.0%           100.0%           86.7%           | 
|TERMINAL (d)       |        7/12 (58%)       4/14 (29%)       9/15 (60%)       15/15 (100%)     12/12 (100%)     8/10 (80%)      | 
|FIRST INCIDENCE    |        145              129              185 (T)          185 (T)          163              138             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.105N         P=0.382N         P=0.162          P=0.061          P=0.111         | 
|POLY 3             |        P<0.001 **       P=0.108N         P=0.589N         P=0.008 **       P=0.008 **       P=0.137         | 
|POLY 1.5           |        P<0.001 **       P=0.118N         P=0.609N         P=0.007 **       P=0.007 **       P=0.123         | 
|POLY 6             |        P<0.001 **       P=0.099N         P=0.568N         P=0.011 *        P=0.011 *        P=0.154         | 
|LOGISTIC REGRESSION|        P=0.002 **       P=0.164N         P=0.639N         P=0.015 *        P=0.013 *        P=0.106         | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.136N         P=0.645N         P=0.008 **       P=0.008 **       P=0.107         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 MG/KG          0.75             1.5              3 MG/KG          6 MG/KG          12 MG/KG        | 
|                   |                         MG/KG            MG/KG                                                              | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/15 (60%)       4/15 (27%)       6/15 (40%)       13/15 (87%)      13/15 (87%)      14/15 (93%)     | 
|POLY-3 RATE (b)    |        9/14.04          4/14.05          6/12.72          13/15.00         13/15.00         14/15.00        | 
|POLY-3 PERCENT (g) |        64.1%            28.5%            47.2%            86.7%            86.7%            93.3%           | 
|TERMINAL (d)       |        7/12 (58%)       4/14 (29%)       6/12 (50%)       10/12 (83%)      11/13 (85%)      8/9 (89%)       | 
|FIRST INCIDENCE    |        70               186 (T)          186 (T)          167              85               27              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.048N*        P=0.247N         P=0.191          P=0.249          P=0.031 *       | 
|POLY 3             |        P<0.001 **       P=0.059N         P=0.314N         P=0.162          P=0.162          P=0.063         | 
|POLY 1.5           |        P<0.001 **       P=0.059N         P=0.292N         P=0.149          P=0.149          P=0.055         | 
|POLY 6             |        P<0.001 **       P=0.059N         P=0.345N         P=0.165          P=0.165          P=0.065         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.063N         P=0.237N         P=0.130          P=0.114          P=0.046 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.070N         P=0.233N         P=0.107          P=0.107          P=0.040 *       | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
                                                                                                                                   
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.