National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4953

TDMS Study 88133-06 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                       TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                                 DATE: 07/12/02  
EXPERIMENT: 88133 TEST: 06                                                                                        TIME: 08:46:58    
                                                                                                                  PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: SKIN APPLICATION                                       NTP:  C88133B     
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                                                              Final#2                                                               
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 MG/KG                                                                       
                                       INCLUDE 002    0 MG/KG                                                                       
                                       INCLUDE 003    0.75    MG/KG                                                                 
                                       INCLUDE 004    0.75    MG/KG                                                                 
                                       INCLUDE 005    1.5     MG/KG                                                                 
                                       INCLUDE 006    1.5     MG/KG                                                                 
                                       INCLUDE 007    3 MG/KG                                                                       
                                       INCLUDE 008    3 MG/KG                                                                       
                                       INCLUDE 009    6 MG/KG                                                                       
                                       INCLUDE 010    6 MG/KG                                                                       
                                       INCLUDE 011    12 MG/KG                                                                      
                                       INCLUDE 012    12 MG/KG                                                                      
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE COLUMBUS                                TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                      DATE: 07/12/02    
EXPERIMENT: 88133 TEST: 06                                                                                        TIME:  8:52:15    
SPECIES: MICE, TG.AC HEMI                                                                                                           
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DERMAL                                                 NTP:  88133B      
CONT: NO1-ES-65406                                                                                                CAS: 15625-89-5   
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                               
                      SUBCHRONIC (26-WEEK) DERMAL STUDY OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                                   
==========================================================================================================================          
WEEK     0 MG/KG                0.75    MG/KG            1.5     MG/KG            3 MG/KG                  6 MG/KG                  
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        22.1       15        21.9     99.1    15      21.3     96.4    15      21.9     99.1    15      21.7     98.2    15      
  1        22.1       15        21.9     99.1    15      21.3     96.4    15      21.9     99.1    15      21.7     98.2    15      
  2        22.7       15        22.5     99.1    15      22.5     99.1    15      22.9    100.9    15      21.2     93.4    15      
  3        24.3       15        23.3     95.9    15      24.0     98.8    15      23.9     98.4    15      23.0     94.7    15      
  4        25.3       15        24.5     96.8    15      24.8     98.0    15      25.1     99.2    15      24.9     98.4    15      
  5        25.9       15        25.2     97.3    15      26.2    101.2    15      26.4    101.9    15      25.9    100.0    15      
  6        27.2       15        26.3     96.7    15      27.5    101.1    15      26.6     97.8    15      27.3    100.4    15      
  7        27.3       15        26.8     98.2    15      27.9    102.2    15      27.4    100.4    15      27.6    101.1    15      
  8        28.2       15        27.5     97.5    15      28.5    101.1    15      28.1     99.6    15      27.9     98.9    15      
  9        28.0       15        26.7     95.4    15      28.7    102.5    15      28.5    101.8    15      27.9     99.6    15      
 10        28.6       15        27.1     94.8    15      29.1    101.7    15      28.6    100.0    15      28.3     99.0    15      
 11        29.2       15        27.9     95.5    15      29.5    101.0    15      29.0     99.3    15      28.8     98.6    15      
 12        29.7       15        28.3     95.3    15      30.6    103.0    14      29.2     98.3    15      28.8     97.0    15      
 13        29.3       15        28.7     98.0    15      30.3    103.4    14      29.7    101.4    15      28.7     98.0    15      
 14        30.0       15        29.2     97.3    15      29.9     99.7    14      30.3    101.0    15      29.3     97.7    14      
 15        30.4       15        28.6     94.1    15      31.7    104.3    13      31.1    102.3    15      30.2     99.3    14      
 16        30.3       14        29.3     96.7    15      31.4    103.6    13      31.0    102.3    15      29.8     98.3    14      
 17        30.1       14        29.9     99.3    15      31.7    105.3    13      31.7    105.3    15      30.3    100.7    14      
 18        31.3       14        30.4     97.1    15      31.8    101.6    13      32.0    102.2    15      31.3    100.0    14      
 19        31.4       14        30.1     95.9    15      32.3    102.9    13      32.2    102.5    15      30.5     97.1    14      
 20        31.3       14        30.9     98.7    15      31.2     99.7    13      32.7    104.5    14      30.6     97.8    14      
 21        31.2       14        30.2     96.8    15      32.6    104.5    13      32.5    104.2    14      30.8     98.7    14      
 22        31.9       14        31.2     97.8    15      33.2    104.1    13      33.4    104.7    14      31.2     97.8    14      
 23        32.1       14        31.1     96.9    15      32.6    101.6    13      32.9    102.5    14      31.0     96.6    14      
 24        31.7       14        31.9    100.6    15      33.9    106.9    12      33.8    106.6    14      31.9    100.6    14      
 25        33.1       14        32.0     96.7    15      35.3    106.6    12      34.3    103.6    14      30.8     93.1    14      
 26        32.5       14        32.1     98.8    15      33.8    104.0    12      34.3    105.5    14      31.6     97.2    14      
 27        33.1       14        32.2     97.3    15      35.2    106.3    12      34.5    104.2    14      32.4     97.9    13      
 28        32.6       14        32.5     99.7    15      36.3    111.3    12      33.8    103.7    14      32.8    100.6    13      
TERM. SAC.            14                         15                       12                       14                       13      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                                                                  
SUBCHRONIC (26-WEEK) DERMAL STUDY OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                                                         
===============================                                                                                                     
     12 MG/KG                                                                                                                       
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    21.0     95.0    15                                                                                                          
  1    21.0     95.0    15                                                                                                          
  2    22.7    100.0    15                                                                                                          
  3    23.9     98.4    15                                                                                                          
  4    24.8     98.0    15                                                                                                          
  5    26.2    101.2    15                                                                                                          
  6    26.7     98.2    15                                                                                                          
  7    27.2     99.6    15                                                                                                          
  8    28.1     99.6    15                                                                                                          
  9    28.0    100.0    15                                                                                                          
 10    28.2     98.6    15                                                                                                          
 11    28.5     97.6    15                                                                                                          
 12    28.9     97.3    15                                                                                                          
 13    29.1     99.3    15                                                                                                          
 14    29.6     98.7    15                                                                                                          
 15    30.0     98.7    15                                                                                                          
 16    30.1     99.3    15                                                                                                          
 17    30.5    101.3    15                                                                                                          
 18    30.7     98.1    15                                                                                                          
 19    31.3     99.7    15                                                                                                          
 20    31.9    101.9    15                                                                                                          
 21    31.7    101.6    15                                                                                                          
 22    32.0    100.3    15                                                                                                          
 23    32.2    100.3    15                                                                                                          
 24    32.9    103.8    13                                                                                                          
 25    32.9     99.4    13                                                                                                          
 26    33.1    101.8    13                                                                                                          
 27    33.5    101.2    12                                                                                                          
 28    33.0    101.2    12                                                                                                          
TERM. SAC.              11                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                             
                      SUBCHRONIC (26-WEEK) DERMAL STUDY OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                                   
==========================================================================================================================          
WEEK     0 MG/KG                0.75    MG/KG            1.5     MG/KG            3 MG/KG                  6 MG/KG                  
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        18.6       15        18.4     98.9    15      18.5     99.5    15      18.6    100.0    15      18.7    100.5    15      
  1        18.6       15        18.4     98.9    15      18.5     99.5    15      18.6    100.0    15      18.7    100.5    15      
  2        19.3       15        19.0     98.4    15      19.4    100.5    15      18.6     96.4    15      18.7     96.9    15      
  3        20.4       15        20.9    102.5    15      20.9    102.5    15      20.7    101.5    15      20.1     98.5    15      
  4        21.7       15        21.6     99.5    15      21.8    100.5    15      21.2     97.7    15      21.5     99.1    15      
  5        22.8       15        22.7     99.6    15      22.8    100.0    15      22.8    100.0    15      22.3     97.8    15      
  6        23.3       15        23.1     99.1    15      23.6    101.3    15      23.6    101.3    15      23.4    100.4    15      
  7        23.8       15        23.7     99.6    15      23.3     97.9    15      23.6     99.2    15      23.0     96.6    15      
  8        22.8       15        23.6    103.5    15      23.6    103.5    15      24.5    107.5    15      24.0    105.3    15      
  9        24.1       15        23.4     97.1    15      23.5     97.5    15      23.0     95.4    15      23.7     98.3    15      
 10        24.3       15        24.6    101.2    15      25.0    102.9    13      24.3    100.0    15      24.5    100.8    15      
 11        24.4       15        25.2    103.3    15      25.3    103.7    13      25.0    102.5    15      24.9    102.0    15      
 12        24.6       15        25.2    102.4    15      25.6    104.1    13      24.8    100.8    15      25.0    101.6    15      
 13        25.1       15        25.5    101.6    15      25.6    102.0    13      25.6    102.0    15      24.8     98.8    15      
 14        24.7       15        25.8    104.5    15      25.7    104.0    13      25.3    102.4    15      25.4    102.8    15      
 15        26.2       15        25.8     98.5    15      26.9    102.7    13      26.0     99.2    15      26.0     99.2    15      
 16        25.7       15        25.8    100.4    15      26.0    101.2    13      26.0    101.2    15      25.7    100.0    15      
 17        26.1       15        26.4    101.1    15      26.9    103.1    13      26.3    100.8    15      26.6    101.9    15      
 18        26.1       15        26.6    101.9    15      26.7    102.3    13      26.1    100.0    15      26.2    100.4    15      
 19        25.5       15        26.2    102.7    15      26.5    103.9    12      26.3    103.1    14      26.3    103.1    15      
 20        26.0       15        26.6    102.3    15      27.3    105.0    12      27.3    105.0    14      27.2    104.6    15      
 21        26.3       15        26.8    101.9    15      27.6    104.9    12      27.0    102.7    14      27.1    103.0    15      
 22        27.0       15        26.7     98.9    15      27.4    101.5    12      26.9     99.6    14      26.3     97.4    15      
 23        27.2       15        26.7     98.2    15      26.9     98.9    12      27.5    101.1    14      26.4     97.1    15      
 24        27.5       15        26.9     97.8    15      28.4    103.3    12      27.6    100.4    14      27.8    101.1    14      
 25        27.5       15        26.9     97.8    15      28.4    103.3    12      27.6    100.4    14      27.6    100.4    14      
 26        27.1       15        27.3    100.7    15      28.1    103.7    12      26.6     98.2    14      27.3    100.7    14      
 27        27.9       15        27.5     98.6    14      27.4     98.2    12      27.9    100.0    14      26.4     94.6    14      
 28        28.2       15        27.6     97.9    14      28.9    102.5    12      28.5    101.1    14      27.9     98.9    14      
TERM. SAC.            15                         14                       12                       14                       14      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                                                
SUBCHRONIC (26-WEEK) DERMAL STUDY OF TRIMETHYLOLPROPANE TRIACRYLATE (TMPTA)                                                         
===============================                                                                                                     
     12 MG/KG                                                                                                                       
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    18.5     99.5    15                                                                                                          
  1    18.5     99.5    15                                                                                                          
  2    19.4    100.5    15                                                                                                          
  3    20.2     99.0    15                                                                                                          
  4    21.7    100.0    15                                                                                                          
  5    22.3     97.8    15                                                                                                          
  6    22.5     96.6    15                                                                                                          
  7    23.2     97.5    15                                                                                                          
  8    23.3    102.2    15                                                                                                          
  9    23.8     98.8    15                                                                                                          
 10    23.2     95.5    15                                                                                                          
 11    24.5    100.4    15                                                                                                          
 12    24.8    100.8    15                                                                                                          
 13    25.2    100.4    15                                                                                                          
 14    25.3    102.4    15                                                                                                          
 15    25.5     97.3    15                                                                                                          
 16    24.6     95.7    15                                                                                                          
 17    26.2    100.4    15                                                                                                          
 18    25.8     98.9    14                                                                                                          
 19    26.8    105.1    14                                                                                                          
 20    27.4    105.4    14                                                                                                          
 21    27.2    103.4    14                                                                                                          
 22    27.5    101.9    14                                                                                                          
 23    27.4    100.7    14                                                                                                          
 24    28.2    102.5    14                                                                                                          
 25    27.6    100.4    14                                                                                                          
 26    28.4    104.8    13                                                                                                          
 27    28.7    102.9    13                                                                                                          
 28    28.7    101.8    12                                                                                                          
TERM. SAC.              12                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
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