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TDMS Study 89002-02 Pathology Tables

NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97
Route: DOSED FEED                                                                                                 Time: 10:49:06

                                                           Core Study




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 002    0 PPM
                               Include 003    200 PPM
                               Include 004    200 PPM
                               Include 005    400 PPM
                               Include 006    400 PPM
                               Include 007    600 PPM
                               Include 008    600 PPM


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           12           12           17                                     
    Natural Death                                      7            5            4            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           33           34           28                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Parasite Metazoan                                             2 (4%)       1 (2%)       5 (10%)                               
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                2 (4%)       5 (10%)      8 (16%)      5 (10%)                               
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Basophilic Focus                                41 (82%)     42 (84%)     44 (88%)     35 (70%)                               
      Clear Cell Focus                                11 (22%)     10 (20%)      8 (16%)      3 (6%)                                
      Eosinophilic Focus                               2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hepatodiaphragmatic Nodule                       9 (18%)      4 (8%)       7 (14%)      3 (6%)                                
      Inflammation, Chronic                           31 (62%)     36 (72%)     33 (66%)     27 (54%)                               
      Mixed Cell Focus                                 7 (14%)      7 (14%)      5 (10%)      2 (4%)                                
      Pigmentation, Bile                                            2 (4%)       1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Thrombosis                                       2 (4%)       1 (2%)                                                          
      Bile Duct, Cyst                                               1 (2%)                                                          
      Bile Duct, Hyperplasia                          24 (48%)     18 (36%)     22 (44%)     19 (38%)                               
      Hepatocyte, Degeneration, Cystic                                                        1 (2%)                                
      Hepatocyte, Necrosis                                          1 (2%)       2 (4%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            7 (14%)      2 (4%)       1 (2%)       3 (6%)                                
      Hepatocyte, Centrilobular, Degeneration                                    1 (2%)       1 (2%)                                
      Hepatocyte, Centrilobular, Necrosis              2 (4%)                    2 (4%)                                             
      Kupffer Cell, Hypertrophy                                                               1 (2%)                                
   Mesentery                                          (8)          (1)          (5)          (5)                                    
      Accessory Spleen                                 1 (13%)      1 (100%)                                                        
      Artery, Inflammation, Chronic Active             1 (13%)                                                                      
      Fat, Necrosis                                    3 (38%)                   3 (60%)      1 (20%)                               
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Cyst                                                                       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                                                            1 (2%)                                
      Acinus, Atrophy                                 10 (20%)     14 (29%)     14 (28%)      9 (18%)                               
      Acinus, Hyperplasia                                                        1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                    3 (6%)       1 (2%)                                
      Epithelium, Hyperplasia                          3 (6%)       1 (2%)       3 (6%)       3 (6%)                                
      Epithelium, Ulcer                                2 (4%)                    3 (6%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Epithelium, Erosion                              1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic Active              1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy, Chronic                         27 (54%)     31 (62%)     36 (72%)     35 (70%)                               
      Necrosis                                                                   1 (2%)                                             
      Atrium, Thrombosis                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)       2 (4%)                                                          
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Degeneration, Cystic                                          4 (8%)       3 (6%)                                             
      Degeneration, Fatty                              9 (18%)     11 (22%)     17 (34%)     15 (30%)                               
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia                                      7 (14%)     12 (24%)     23 (46%)     12 (24%)                               
      Hypertrophy                                      1 (2%)       6 (12%)      8 (16%)      7 (14%)                               
      Pigmentation                                     1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      3 (6%)       7 (14%)      6 (12%)      7 (14%)                               
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (46)         (44)         (41)         (47)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
      Pars Distalis, Cyst                             35 (70%)     28 (56%)     34 (68%)     32 (64%)                               
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      24 (48%)     21 (42%)     26 (52%)     27 (54%)                               
      Pars Intermedia, Cyst                            1 (2%)       2 (4%)                    1 (2%)                                
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             16 (32%)     23 (46%)     27 (54%)     20 (40%)                               
      Follicular Cell, Hyperplasia, Cystic             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (48)         (50)                                   
      Hyperplasia                                     10 (20%)     11 (22%)     13 (27%)     11 (22%)                               
      Inflammation, Chronic Active                     4 (8%)      11 (22%)      4 (8%)       5 (10%)                               
      Bilateral, Hyperplasia                                        1 (2%)       1 (2%)                                             
      Duct, Cyst                                       1 (2%)                                 1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             3 (6%)       6 (12%)      4 (8%)       8 (16%)                               
      Bilateral, Cyst                                  1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Hydrometra                                                    2 (4%)                    2 (4%)                                
      Endometrium, Hyperplasia, Cystic                              1 (2%)       1 (2%)       1 (2%)                                
   Vagina                                             (2)                       (1)                                                 
      Hypertrophy                                      1 (50%)                                                                      
      Inflammation, Suppurative                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     11 (22%)     13 (26%)     17 (34%)     21 (42%)                               
      Hyperplasia, Histiocytic                                      1 (2%)                    1 (2%)                                
      Myelofibrosis                                    1 (2%)       1 (2%)                                                          
   Lymph Node                                         (35)         (27)         (26)         (28)                                   
      Mediastinal, Hemorrhage                                                    1 (4%)                                             
      Mediastinal, Pigmentation, Hemosiderin          30 (86%)     22 (81%)     21 (81%)     24 (86%)                               
   Lymph Node, Mandibular                             (50)         (49)         (50)         (50)                                   
      Ectasia                                          1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Ectasia                                                                    3 (6%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                                                        1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 9 (18%)     12 (24%)      6 (12%)     10 (20%)                               
      Necrosis                                         1 (2%)                                 1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
   Thymus                                             (48)         (44)         (48)         (47)                                   
      Cyst                                                          1 (2%)       3 (6%)                                             
      Ectopic Parathyroid Gland                                                               2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                             2 (4%)       2 (4%)                                                          
      Hyperplasia, Cystic                             43 (86%)     44 (88%)     45 (90%)     42 (84%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Epidermis, Hyperplasia                           1 (2%)                    2 (4%)                                             
      Epidermis, Ulcer                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteopetrosis                                    6 (12%)      1 (2%)       4 (8%)       2 (4%)                                
      Mandible, Cyst                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                       1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                    12 (24%)     12 (24%)     17 (34%)     15 (30%)                               
      Metaplasia, Osseous                                           1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 5 (10%)      2 (4%)       5 (10%)      3 (6%)                                
      Alveolus, Infiltration Cellular, Histiocyte     41 (82%)     42 (84%)     45 (90%)     46 (92%)                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Fungus                                           6 (12%)      2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                    13 (26%)     13 (26%)      7 (14%)      6 (12%)                               
      Nasolacrimal Duct, Inflammation, Suppurative     9 (18%)      6 (12%)     10 (20%)      6 (12%)                               
      Respiratory Epithelium, Hyperplasia             10 (20%)      3 (6%)       2 (4%)       4 (8%)                                
      Respiratory Epithelium, Metaplasia, Squamous     3 (6%)       3 (6%)                    1 (2%)                                
      Vein, Turbinate, Septum, Thrombosis                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (3)          (2)          (2)                                    
      Atrophy                                          2 (67%)                                                                      
      Lens, Cataract                                                2 (67%)      2 (100%)     2 (100%)                              
      Lens, Fibrosis                                                1 (33%)                                                         
      Lens, Synechia                                                2 (67%)                                                         
      Retina, Atrophy                                               3 (100%)     2 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                                           1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hydronephrosis                                                                          1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Nephropathy, Chronic                            44 (88%)     46 (92%)     44 (88%)     48 (96%)                               
      Papilla, Necrosis                                             1 (2%)                                                          
      Pelvis, Inflammation, Suppurative                             1 (2%)                                                          
      Renal Tubule, Pigmentation                      48 (96%)     48 (96%)     50 (100%)    50 (100%)                              
   Urinary Bladder                                    (50)         (50)         (49)         (49)                                   
      Calculus Micro Observation Only                               1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28           28           24           11                                     
    Natural Death                                     10            6            5            8                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                      2                                     
    Terminal Sacrifice                                11           16           21           29                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (49)                                   
      Parasite Metazoan                                1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)                                   
      Parasite Metazoan                                1 (2%)       5 (10%)      3 (6%)       3 (6%)                                
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic Active                                                            1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
      Epithelium, Erosion                              1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (50)         (50)         (49)                                   
      Parasite Metazoan                                                          1 (2%)                                             
      Peyer's Patch, Inflammation, Chronic Active                                             1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)                    1 (2%)       1 (2%)                                
      Basophilic Focus                                17 (34%)     14 (28%)     20 (40%)     16 (32%)                               
      Clear Cell Focus                                 6 (12%)      2 (4%)       7 (14%)      5 (10%)                               
      Eosinophilic Focus                               2 (4%)       2 (4%)       1 (2%)       9 (18%)                               
      Hepatodiaphragmatic Nodule                                    7 (14%)      6 (12%)      8 (16%)                               
      Inflammation, Chronic                           22 (44%)     16 (32%)     22 (44%)     22 (44%)                               
      Mixed Cell Focus                                 1 (2%)                    1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                          49 (98%)     47 (94%)     46 (92%)     48 (96%)                               
      Hepatocyte, Degeneration, Cystic                16 (32%)     22 (44%)     28 (56%)     39 (78%)                               
      Hepatocyte, Necrosis                             3 (6%)                    2 (4%)       1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic           10 (20%)      3 (6%)       5 (10%)      7 (14%)                               
      Hepatocyte, Centrilobular, Degeneration          2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Hepatocyte, Centrilobular, Necrosis              2 (4%)       4 (8%)       1 (2%)       2 (4%)                                
      Kupffer Cell, Hypertrophy                        1 (2%)                                                                       
      Oval Cell, Hyperplasia                                        1 (2%)                                                          
      Portal Vein, Thrombosis                                                    1 (2%)                                             
   Mesentery                                          (15)         (12)         (15)         (11)                                   
      Accessory Spleen                                                           1 (7%)                                             
      Inflammation, Chronic Active                                                            1 (9%)                                
      Fat, Necrosis                                   12 (80%)      8 (67%)      8 (53%)      8 (73%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Oral Mucosa                                        (1)          (1)          (1)                                                 
      Gingival, Inflammation, Suppurative                                        1 (100%)                                           
      Pharyngeal, Necrosis                                          1 (100%)                                                        
   Pancreas                                           (50)         (50)         (50)         (48)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Acinus, Atrophy                                 12 (24%)     27 (54%)     16 (32%)     27 (56%)                               
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                    10 (20%)      4 (8%)       3 (6%)       2 (4%)                                
      Epithelium, Hyperplasia                          8 (16%)      8 (16%)      4 (8%)       3 (6%)                                
      Epithelium, Hyperplasia, Basal Cell                                        2 (4%)                                             
      Epithelium, Ulcer                                8 (16%)      3 (6%)       4 (8%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mineralization                                   1 (2%)                                 1 (2%)                                
      Epithelium, Erosion                              2 (4%)       1 (2%)                    2 (4%)                                
      Epithelium, Ulcer                                1 (2%)                    1 (2%)       1 (2%)                                
   Tongue                                             (1)                       (1)          (1)                                    
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Mineralization                            1 (2%)                                 1 (2%)                                
      Pulmonary Artery, Thrombosis                     1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy, Chronic                         42 (84%)     41 (82%)     41 (82%)     44 (88%)                               
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Atrium, Thrombosis                               7 (14%)      7 (14%)      4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                                          1 (2%)       2 (4%)                                
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)       1 (2%)       1 (2%)                                             
      Degeneration, Fatty                             28 (56%)     19 (38%)     16 (32%)     20 (40%)                               
      Hyperplasia                                     13 (26%)     11 (22%)     13 (26%)     15 (30%)                               
      Hypertrophy                                                   1 (2%)       2 (4%)       4 (8%)                                
      Necrosis                                         1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Degeneration, Fatty                                           1 (2%)                                                          
      Hyperplasia                                     18 (36%)     27 (54%)     22 (44%)     25 (50%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (48)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      2 (4%)                                 1 (2%)                                
   Parathyroid Gland                                  (47)         (45)         (47)         (46)                                   
      Hyperplasia                                      9 (19%)      3 (7%)                                                          
   Pituitary Gland                                    (50)         (50)         (49)         (50)                                   
      Craniopharyngeal Duct, Cyst                      1 (2%)                                                                       
      Pars Distalis, Cyst                              7 (14%)      8 (16%)      3 (6%)       6 (12%)                               
      Pars Distalis, Hemorrhage                                                  1 (2%)                                             
      Pars Distalis, Hyperplasia                      22 (44%)     13 (26%)     15 (31%)     21 (42%)                               
      Pars Intermedia, Cyst                                         1 (2%)       3 (6%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Ectopic Tissue                                                                          1 (2%)                                
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia                             16 (32%)      8 (16%)     21 (42%)     19 (38%)                               
      Follicle, Cyst                                                1 (2%)       1 (2%)                                             
      Follicular Cell, Hyperplasia, Cystic             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)          (1)                                                              
      Inflammation, Chronic Active                     2 (100%)     1 (100%)                                                        
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                               2 (4%)                                                          
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      7 (14%)      7 (14%)      7 (14%)      4 (8%)                                
      Inflammation, Chronic Active                    42 (84%)     40 (80%)     47 (94%)     47 (94%)                               
      Duct, Cyst                                       2 (4%)                    2 (4%)                                             
   Prostate                                           (50)         (50)         (50)         (49)                                   
      Inflammation, Chronic Active                    38 (76%)     34 (68%)     32 (64%)     26 (53%)                               
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Arteriole, Inflammation, Chronic                 1 (2%)                                                                       
      Germinal Epithelium, Atrophy                     2 (4%)       2 (4%)       4 (8%)       4 (8%)                                
      Interstitial Cell, Hyperplasia                  10 (20%)     10 (20%)      6 (12%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Atrophy, Focal                                                1 (2%)                                                          
      Hyperplasia                                     30 (60%)     33 (66%)     36 (72%)     32 (64%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Myelofibrosis                                    1 (2%)       2 (4%)                    1 (2%)                                
   Lymph Node                                         (34)         (34)         (35)         (41)                                   
      Lumbar, Hyperplasia, Lymphoid                                 1 (3%)                                                          
      Mediastinal, Hyperplasia, Lymphoid                            1 (3%)       3 (9%)                                             
      Mediastinal, Necrosis                                                      1 (3%)                                             
      Mediastinal, Pigmentation, Hemosiderin          25 (74%)     19 (56%)     23 (66%)     36 (88%)                               
      Pancreatic, Ectasia                                                                     1 (2%)                                
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Ectasia                                                                    2 (4%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
      Ectasia                                                                    1 (2%)       2 (4%)                                
      Erythrophagocytosis                                           1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         5 (10%)      3 (6%)       3 (6%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 4 (8%)                    1 (2%)                                             
      Necrosis                                         2 (4%)                    2 (4%)       2 (4%)                                
   Thymus                                             (49)         (46)         (49)         (47)                                   
      Ectopic Parathyroid Gland                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (47)         (50)         (49)                                   
      Cyst                                                                       1 (2%)       1 (2%)                                
      Hyperplasia, Cystic                             36 (73%)     34 (72%)     24 (48%)     28 (57%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                    2 (4%)                                
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
      Epidermis, Hyperkeratosis                                     1 (2%)       3 (6%)       3 (6%)                                
      Epidermis, Hyperplasia                           1 (2%)                                                                       
      Sebaceous Gland, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Osteopetrosis                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                                                 1 (2%)                                
      Hemorrhage                                       4 (8%)                    6 (12%)      2 (4%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)                    5 (10%)      4 (8%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       5 (10%)      3 (6%)       2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte     39 (78%)     37 (74%)     39 (78%)     40 (80%)                               
      Interstitium, Mineralization                                                            1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Fungus                                          21 (42%)     15 (30%)     10 (20%)     11 (22%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic Active                    25 (50%)     19 (38%)     22 (44%)     18 (36%)                               
      Nasolacrimal Duct, Inflammation, Suppurative     6 (12%)      6 (12%)      6 (12%)      5 (10%)                               
      Respiratory Epithelium, Hyperplasia             24 (48%)     16 (32%)     17 (34%)     13 (26%)                               
      Respiratory Epithelium, Metaplasia, Squamous    12 (24%)      9 (18%)      8 (16%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (4)          (1)          (3)                                    
      Cornea, Inflammation, Chronic Active                                       1 (100%)                                           
      Lens, Cataract                                   1 (100%)     3 (75%)                   3 (100%)                              
      Retina, Atrophy                                  1 (100%)     4 (100%)                  3 (100%)                              
      Retina, Hemorrhage                                            1 (25%)                                                         
      Sclera, Metaplasia, Osseous                                   1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                 1 (2%)                                                          
      Cyst                                             1 (2%)       4 (8%)       1 (2%)       1 (2%)                                
      Infarct                                                                    1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Nephropathy, Chronic                            50 (100%)    49 (98%)     50 (100%)    49 (98%)                               
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Pigmentation                      49 (98%)     48 (96%)     49 (98%)     50 (100%)                              
   Urinary Bladder                                    (48)         (50)         (50)         (49)                                   
      Hemorrhage                                                                              1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
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