TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
Core Study
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 PPM
Include 002 0 PPM
Include 003 200 PPM
Include 004 200 PPM
Include 005 400 PPM
Include 006 400 PPM
Include 007 600 PPM
Include 008 600 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 50 50 50
Early Deaths
Moribund Sacrifice 15 12 12 17
Natural Death 7 5 4 5
Survivors
Terminal Sacrifice 28 33 34 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
Parasite Metazoan 2 (4%) 1 (2%) 5 (10%)
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 2 (4%) 5 (10%) 8 (16%) 5 (10%)
Intestine Small, Ileum (50) (50) (50) (50)
Parasite Metazoan 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 41 (82%) 42 (84%) 44 (88%) 35 (70%)
Clear Cell Focus 11 (22%) 10 (20%) 8 (16%) 3 (6%)
Eosinophilic Focus 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 9 (18%) 4 (8%) 7 (14%) 3 (6%)
Inflammation, Chronic 31 (62%) 36 (72%) 33 (66%) 27 (54%)
Mixed Cell Focus 7 (14%) 7 (14%) 5 (10%) 2 (4%)
Pigmentation, Bile 2 (4%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 2 (4%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 24 (48%) 18 (36%) 22 (44%) 19 (38%)
Hepatocyte, Degeneration, Cystic 1 (2%)
Hepatocyte, Necrosis 1 (2%) 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic 7 (14%) 2 (4%) 1 (2%) 3 (6%)
Hepatocyte, Centrilobular, Degeneration 1 (2%) 1 (2%)
Hepatocyte, Centrilobular, Necrosis 2 (4%) 2 (4%)
Kupffer Cell, Hypertrophy 1 (2%)
Mesentery (8) (1) (5) (5)
Accessory Spleen 1 (13%) 1 (100%)
Artery, Inflammation, Chronic Active 1 (13%)
Fat, Necrosis 3 (38%) 3 (60%) 1 (20%)
Pancreas (50) (49) (50) (50)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 10 (20%) 14 (29%) 14 (28%) 9 (18%)
Acinus, Hyperplasia 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 3 (6%) 1 (2%)
Epithelium, Hyperplasia 3 (6%) 1 (2%) 3 (6%) 3 (6%)
Epithelium, Ulcer 2 (4%) 3 (6%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Epithelium, Erosion 1 (2%) 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Inflammation, Chronic Active 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy, Chronic 27 (54%) 31 (62%) 36 (72%) 35 (70%)
Necrosis 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (4%)
Atrophy 1 (2%) 1 (2%)
Degeneration, Cystic 4 (8%) 3 (6%)
Degeneration, Fatty 9 (18%) 11 (22%) 17 (34%) 15 (30%)
Fibrosis 1 (2%)
Hyperplasia 7 (14%) 12 (24%) 23 (46%) 12 (24%)
Hypertrophy 1 (2%) 6 (12%) 8 (16%) 7 (14%)
Pigmentation 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 3 (6%) 7 (14%) 6 (12%) 7 (14%)
Islets, Pancreatic (50) (49) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (46) (44) (41) (47)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Pars Distalis, Cyst 35 (70%) 28 (56%) 34 (68%) 32 (64%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 24 (48%) 21 (42%) 26 (52%) 27 (54%)
Pars Intermedia, Cyst 1 (2%) 2 (4%) 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (50) (50) (50) (50)
C-Cell, Hyperplasia 16 (32%) 23 (46%) 27 (54%) 20 (40%)
Follicular Cell, Hyperplasia, Cystic 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (48) (50)
Hyperplasia 10 (20%) 11 (22%) 13 (27%) 11 (22%)
Inflammation, Chronic Active 4 (8%) 11 (22%) 4 (8%) 5 (10%)
Bilateral, Hyperplasia 1 (2%) 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 3 (6%) 6 (12%) 4 (8%) 8 (16%)
Bilateral, Cyst 1 (2%)
Uterus (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hydrometra 2 (4%) 2 (4%)
Endometrium, Hyperplasia, Cystic 1 (2%) 1 (2%) 1 (2%)
Vagina (2) (1)
Hypertrophy 1 (50%)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 11 (22%) 13 (26%) 17 (34%) 21 (42%)
Hyperplasia, Histiocytic 1 (2%) 1 (2%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (35) (27) (26) (28)
Mediastinal, Hemorrhage 1 (4%)
Mediastinal, Pigmentation, Hemosiderin 30 (86%) 22 (81%) 21 (81%) 24 (86%)
Lymph Node, Mandibular (50) (49) (50) (50)
Ectasia 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Ectasia 3 (6%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 9 (18%) 12 (24%) 6 (12%) 10 (20%)
Necrosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation, Hemosiderin 1 (2%)
Thymus (48) (44) (48) (47)
Cyst 1 (2%) 3 (6%)
Ectopic Parathyroid Gland 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Cyst 2 (4%) 2 (4%)
Hyperplasia, Cystic 43 (86%) 44 (88%) 45 (90%) 42 (84%)
Inflammation, Chronic 1 (2%)
Skin (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Epidermis, Hyperplasia 1 (2%) 2 (4%)
Epidermis, Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteopetrosis 6 (12%) 1 (2%) 4 (8%) 2 (4%)
Mandible, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Gliosis 1 (2%)
Hemorrhage 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Inflammation, Chronic Active 12 (24%) 12 (24%) 17 (34%) 15 (30%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 2 (4%) 5 (10%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 41 (82%) 42 (84%) 45 (90%) 46 (92%)
Nose (50) (50) (50) (50)
Fungus 6 (12%) 2 (4%) 1 (2%)
Inflammation, Chronic Active 13 (26%) 13 (26%) 7 (14%) 6 (12%)
Nasolacrimal Duct, Inflammation, Suppurative 9 (18%) 6 (12%) 10 (20%) 6 (12%)
Respiratory Epithelium, Hyperplasia 10 (20%) 3 (6%) 2 (4%) 4 (8%)
Respiratory Epithelium, Metaplasia, Squamous 3 (6%) 3 (6%) 1 (2%)
Vein, Turbinate, Septum, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (3) (2) (2)
Atrophy 2 (67%)
Lens, Cataract 2 (67%) 2 (100%) 2 (100%)
Lens, Fibrosis 1 (33%)
Lens, Synechia 2 (67%)
Retina, Atrophy 3 (100%) 2 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Mineralization 1 (2%)
Nephropathy, Chronic 44 (88%) 46 (92%) 44 (88%) 48 (96%)
Papilla, Necrosis 1 (2%)
Pelvis, Inflammation, Suppurative 1 (2%)
Renal Tubule, Pigmentation 48 (96%) 48 (96%) 50 (100%) 50 (100%)
Urinary Bladder (50) (50) (49) (49)
Calculus Micro Observation Only 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 50 50 50
Early Deaths
Moribund Sacrifice 28 28 24 11
Natural Death 10 6 5 8
Survivors
Natural Death 1 2
Terminal Sacrifice 11 16 21 29
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (49)
Parasite Metazoan 1 (2%) 3 (6%) 1 (2%) 3 (6%)
Intestine Large, Rectum (50) (50) (50) (49)
Parasite Metazoan 1 (2%) 5 (10%) 3 (6%) 3 (6%)
Intestine Large, Cecum (50) (50) (50) (50)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (50) (50) (50) (49)
Epithelium, Erosion 1 (2%)
Intestine Small, Ileum (49) (50) (50) (49)
Parasite Metazoan 1 (2%)
Peyer's Patch, Inflammation, Chronic Active 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 1 (2%) 1 (2%)
Basophilic Focus 17 (34%) 14 (28%) 20 (40%) 16 (32%)
Clear Cell Focus 6 (12%) 2 (4%) 7 (14%) 5 (10%)
Eosinophilic Focus 2 (4%) 2 (4%) 1 (2%) 9 (18%)
Hepatodiaphragmatic Nodule 7 (14%) 6 (12%) 8 (16%)
Inflammation, Chronic 22 (44%) 16 (32%) 22 (44%) 22 (44%)
Mixed Cell Focus 1 (2%) 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 49 (98%) 47 (94%) 46 (92%) 48 (96%)
Hepatocyte, Degeneration, Cystic 16 (32%) 22 (44%) 28 (56%) 39 (78%)
Hepatocyte, Necrosis 3 (6%) 2 (4%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 10 (20%) 3 (6%) 5 (10%) 7 (14%)
Hepatocyte, Centrilobular, Degeneration 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Hepatocyte, Centrilobular, Necrosis 2 (4%) 4 (8%) 1 (2%) 2 (4%)
Kupffer Cell, Hypertrophy 1 (2%)
Oval Cell, Hyperplasia 1 (2%)
Portal Vein, Thrombosis 1 (2%)
Mesentery (15) (12) (15) (11)
Accessory Spleen 1 (7%)
Inflammation, Chronic Active 1 (9%)
Fat, Necrosis 12 (80%) 8 (67%) 8 (53%) 8 (73%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Oral Mucosa (1) (1) (1)
Gingival, Inflammation, Suppurative 1 (100%)
Pharyngeal, Necrosis 1 (100%)
Pancreas (50) (50) (50) (48)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 12 (24%) 27 (54%) 16 (32%) 27 (56%)
Artery, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Inflammation, Chronic Active 10 (20%) 4 (8%) 3 (6%) 2 (4%)
Epithelium, Hyperplasia 8 (16%) 8 (16%) 4 (8%) 3 (6%)
Epithelium, Hyperplasia, Basal Cell 2 (4%)
Epithelium, Ulcer 8 (16%) 3 (6%) 4 (8%) 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Epithelium, Erosion 2 (4%) 1 (2%) 2 (4%)
Epithelium, Ulcer 1 (2%) 1 (2%) 1 (2%)
Tongue (1) (1) (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Aorta, Mineralization 1 (2%) 1 (2%)
Pulmonary Artery, Thrombosis 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy, Chronic 42 (84%) 41 (82%) 41 (82%) 44 (88%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Atrium, Thrombosis 7 (14%) 7 (14%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (4%)
Atrophy 1 (2%)
Degeneration, Cystic 1 (2%) 1 (2%) 1 (2%)
Degeneration, Fatty 28 (56%) 19 (38%) 16 (32%) 20 (40%)
Hyperplasia 13 (26%) 11 (22%) 13 (26%) 15 (30%)
Hypertrophy 1 (2%) 2 (4%) 4 (8%)
Necrosis 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Degeneration, Fatty 1 (2%)
Hyperplasia 18 (36%) 27 (54%) 22 (44%) 25 (50%)
Islets, Pancreatic (50) (50) (50) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 2 (4%) 1 (2%)
Parathyroid Gland (47) (45) (47) (46)
Hyperplasia 9 (19%) 3 (7%)
Pituitary Gland (50) (50) (49) (50)
Craniopharyngeal Duct, Cyst 1 (2%)
Pars Distalis, Cyst 7 (14%) 8 (16%) 3 (6%) 6 (12%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 22 (44%) 13 (26%) 15 (31%) 21 (42%)
Pars Intermedia, Cyst 1 (2%) 3 (6%) 1 (2%)
Thyroid Gland (50) (50) (50) (50)
Ectopic Tissue 1 (2%)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 16 (32%) 8 (16%) 21 (42%) 19 (38%)
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia, Cystic 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2) (1)
Inflammation, Chronic Active 2 (100%) 1 (100%)
Epididymis (50) (50) (50) (50)
Granuloma Sperm 2 (4%)
Preputial Gland (50) (50) (50) (50)
Hyperplasia 7 (14%) 7 (14%) 7 (14%) 4 (8%)
Inflammation, Chronic Active 42 (84%) 40 (80%) 47 (94%) 47 (94%)
Duct, Cyst 2 (4%) 2 (4%)
Prostate (50) (50) (50) (49)
Inflammation, Chronic Active 38 (76%) 34 (68%) 32 (64%) 26 (53%)
Epithelium, Hyperplasia 1 (2%)
Testes (50) (50) (50) (50)
Arteriole, Inflammation, Chronic 1 (2%)
Germinal Epithelium, Atrophy 2 (4%) 2 (4%) 4 (8%) 4 (8%)
Interstitial Cell, Hyperplasia 10 (20%) 10 (20%) 6 (12%) 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Atrophy, Focal 1 (2%)
Hyperplasia 30 (60%) 33 (66%) 36 (72%) 32 (64%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Myelofibrosis 1 (2%) 2 (4%) 1 (2%)
Lymph Node (34) (34) (35) (41)
Lumbar, Hyperplasia, Lymphoid 1 (3%)
Mediastinal, Hyperplasia, Lymphoid 1 (3%) 3 (9%)
Mediastinal, Necrosis 1 (3%)
Mediastinal, Pigmentation, Hemosiderin 25 (74%) 19 (56%) 23 (66%) 36 (88%)
Pancreatic, Ectasia 1 (2%)
Lymph Node, Mandibular (50) (50) (50) (50)
Ectasia 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (49)
Ectasia 1 (2%) 2 (4%)
Erythrophagocytosis 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Spleen (50) (50) (50) (50)
Fibrosis 5 (10%) 3 (6%) 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 1 (2%)
Necrosis 2 (4%) 2 (4%) 2 (4%)
Thymus (49) (46) (49) (47)
Ectopic Parathyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (47) (50) (49)
Cyst 1 (2%) 1 (2%)
Hyperplasia, Cystic 36 (73%) 34 (72%) 24 (48%) 28 (57%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%)
Epidermis, Hyperkeratosis 1 (2%) 3 (6%) 3 (6%)
Epidermis, Hyperplasia 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%)
Osteopetrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Gliosis 1 (2%)
Hemorrhage 4 (8%) 6 (12%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Foreign Body 1 (2%)
Inflammation, Chronic Active 3 (6%) 5 (10%) 4 (8%)
Alveolar Epithelium, Hyperplasia 1 (2%) 5 (10%) 3 (6%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 39 (78%) 37 (74%) 39 (78%) 40 (80%)
Interstitium, Mineralization 1 (2%)
Nose (50) (50) (50) (50)
Fungus 21 (42%) 15 (30%) 10 (20%) 11 (22%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 25 (50%) 19 (38%) 22 (44%) 18 (36%)
Nasolacrimal Duct, Inflammation, Suppurative 6 (12%) 6 (12%) 6 (12%) 5 (10%)
Respiratory Epithelium, Hyperplasia 24 (48%) 16 (32%) 17 (34%) 13 (26%)
Respiratory Epithelium, Metaplasia, Squamous 12 (24%) 9 (18%) 8 (16%) 7 (14%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (4) (1) (3)
Cornea, Inflammation, Chronic Active 1 (100%)
Lens, Cataract 1 (100%) 3 (75%) 3 (100%)
Retina, Atrophy 1 (100%) 4 (100%) 3 (100%)
Retina, Hemorrhage 1 (25%)
Sclera, Metaplasia, Osseous 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 1 (2%)
Cyst 1 (2%) 4 (8%) 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Suppurative 1 (2%)
Nephropathy, Chronic 50 (100%) 49 (98%) 50 (100%) 49 (98%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Pigmentation 49 (98%) 48 (96%) 49 (98%) 50 (100%)
Urinary Bladder (48) (50) (50) (49)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:49:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 200 PPM 400 PPM 600 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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