Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/6133

TDMS Study 89002-02 Pathology Tables

NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97
Route: DOSED FEED                                                                                                 Time: 10:49:06

                                                           Core Study




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 002    0 PPM
                               Include 003    200 PPM
                               Include 004    200 PPM
                               Include 005    400 PPM
                               Include 006    400 PPM
                               Include 007    600 PPM
                               Include 008    600 PPM


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           12           12           17                                     
    Natural Death                                      7            5            4            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           33           34           28                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Parasite Metazoan                                             2 (4%)       1 (2%)       5 (10%)                               
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                2 (4%)       5 (10%)      8 (16%)      5 (10%)                               
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Basophilic Focus                                41 (82%)     42 (84%)     44 (88%)     35 (70%)                               
      Clear Cell Focus                                11 (22%)     10 (20%)      8 (16%)      3 (6%)                                
      Eosinophilic Focus                               2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hepatodiaphragmatic Nodule                       9 (18%)      4 (8%)       7 (14%)      3 (6%)                                
      Inflammation, Chronic                           31 (62%)     36 (72%)     33 (66%)     27 (54%)                               
      Mixed Cell Focus                                 7 (14%)      7 (14%)      5 (10%)      2 (4%)                                
      Pigmentation, Bile                                            2 (4%)       1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Thrombosis                                       2 (4%)       1 (2%)                                                          
      Bile Duct, Cyst                                               1 (2%)                                                          
      Bile Duct, Hyperplasia                          24 (48%)     18 (36%)     22 (44%)     19 (38%)                               
      Hepatocyte, Degeneration, Cystic                                                        1 (2%)                                
      Hepatocyte, Necrosis                                          1 (2%)       2 (4%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            7 (14%)      2 (4%)       1 (2%)       3 (6%)                                
      Hepatocyte, Centrilobular, Degeneration                                    1 (2%)       1 (2%)                                
      Hepatocyte, Centrilobular, Necrosis              2 (4%)                    2 (4%)                                             
      Kupffer Cell, Hypertrophy                                                               1 (2%)                                
   Mesentery                                          (8)          (1)          (5)          (5)                                    
      Accessory Spleen                                 1 (13%)      1 (100%)                                                        
      Artery, Inflammation, Chronic Active             1 (13%)                                                                      
      Fat, Necrosis                                    3 (38%)                   3 (60%)      1 (20%)                               
   Pancreas                                           (50)         (49)         (50)         (50)                                   
      Cyst                                                                       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                                                            1 (2%)                                
      Acinus, Atrophy                                 10 (20%)     14 (29%)     14 (28%)      9 (18%)                               
      Acinus, Hyperplasia                                                        1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                    3 (6%)       1 (2%)                                
      Epithelium, Hyperplasia                          3 (6%)       1 (2%)       3 (6%)       3 (6%)                                
      Epithelium, Ulcer                                2 (4%)                    3 (6%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Epithelium, Erosion                              1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic Active              1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy, Chronic                         27 (54%)     31 (62%)     36 (72%)     35 (70%)                               
      Necrosis                                                                   1 (2%)                                             
      Atrium, Thrombosis                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)       2 (4%)                                                          
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Degeneration, Cystic                                          4 (8%)       3 (6%)                                             
      Degeneration, Fatty                              9 (18%)     11 (22%)     17 (34%)     15 (30%)                               
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia                                      7 (14%)     12 (24%)     23 (46%)     12 (24%)                               
      Hypertrophy                                      1 (2%)       6 (12%)      8 (16%)      7 (14%)                               
      Pigmentation                                     1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      3 (6%)       7 (14%)      6 (12%)      7 (14%)                               
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (46)         (44)         (41)         (47)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
      Pars Distalis, Cyst                             35 (70%)     28 (56%)     34 (68%)     32 (64%)                               
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      24 (48%)     21 (42%)     26 (52%)     27 (54%)                               
      Pars Intermedia, Cyst                            1 (2%)       2 (4%)                    1 (2%)                                
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             16 (32%)     23 (46%)     27 (54%)     20 (40%)                               
      Follicular Cell, Hyperplasia, Cystic             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (48)         (50)                                   
      Hyperplasia                                     10 (20%)     11 (22%)     13 (27%)     11 (22%)                               
      Inflammation, Chronic Active                     4 (8%)      11 (22%)      4 (8%)       5 (10%)                               
      Bilateral, Hyperplasia                                        1 (2%)       1 (2%)                                             
      Duct, Cyst                                       1 (2%)                                 1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             3 (6%)       6 (12%)      4 (8%)       8 (16%)                               
      Bilateral, Cyst                                  1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Hydrometra                                                    2 (4%)                    2 (4%)                                
      Endometrium, Hyperplasia, Cystic                              1 (2%)       1 (2%)       1 (2%)                                
   Vagina                                             (2)                       (1)                                                 
      Hypertrophy                                      1 (50%)                                                                      
      Inflammation, Suppurative                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     11 (22%)     13 (26%)     17 (34%)     21 (42%)                               
      Hyperplasia, Histiocytic                                      1 (2%)                    1 (2%)                                
      Myelofibrosis                                    1 (2%)       1 (2%)                                                          
   Lymph Node                                         (35)         (27)         (26)         (28)                                   
      Mediastinal, Hemorrhage                                                    1 (4%)                                             
      Mediastinal, Pigmentation, Hemosiderin          30 (86%)     22 (81%)     21 (81%)     24 (86%)                               
   Lymph Node, Mandibular                             (50)         (49)         (50)         (50)                                   
      Ectasia                                          1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Ectasia                                                                    3 (6%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                                                        1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 9 (18%)     12 (24%)      6 (12%)     10 (20%)                               
      Necrosis                                         1 (2%)                                 1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
   Thymus                                             (48)         (44)         (48)         (47)                                   
      Cyst                                                          1 (2%)       3 (6%)                                             
      Ectopic Parathyroid Gland                                                               2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                             2 (4%)       2 (4%)                                                          
      Hyperplasia, Cystic                             43 (86%)     44 (88%)     45 (90%)     42 (84%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Epidermis, Hyperplasia                           1 (2%)                    2 (4%)                                             
      Epidermis, Ulcer                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteopetrosis                                    6 (12%)      1 (2%)       4 (8%)       2 (4%)                                
      Mandible, Cyst                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                       1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                    12 (24%)     12 (24%)     17 (34%)     15 (30%)                               
      Metaplasia, Osseous                                           1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 5 (10%)      2 (4%)       5 (10%)      3 (6%)                                
      Alveolus, Infiltration Cellular, Histiocyte     41 (82%)     42 (84%)     45 (90%)     46 (92%)                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Fungus                                           6 (12%)      2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                    13 (26%)     13 (26%)      7 (14%)      6 (12%)                               
      Nasolacrimal Duct, Inflammation, Suppurative     9 (18%)      6 (12%)     10 (20%)      6 (12%)                               
      Respiratory Epithelium, Hyperplasia             10 (20%)      3 (6%)       2 (4%)       4 (8%)                                
      Respiratory Epithelium, Metaplasia, Squamous     3 (6%)       3 (6%)                    1 (2%)                                
      Vein, Turbinate, Septum, Thrombosis                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (3)          (2)          (2)                                    
      Atrophy                                          2 (67%)                                                                      
      Lens, Cataract                                                2 (67%)      2 (100%)     2 (100%)                              
      Lens, Fibrosis                                                1 (33%)                                                         
      Lens, Synechia                                                2 (67%)                                                         
      Retina, Atrophy                                               3 (100%)     2 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                                           1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hydronephrosis                                                                          1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Nephropathy, Chronic                            44 (88%)     46 (92%)     44 (88%)     48 (96%)                               
      Papilla, Necrosis                                             1 (2%)                                                          
      Pelvis, Inflammation, Suppurative                             1 (2%)                                                          
      Renal Tubule, Pigmentation                      48 (96%)     48 (96%)     50 (100%)    50 (100%)                              
   Urinary Bladder                                    (50)         (50)         (49)         (49)                                   
      Calculus Micro Observation Only                               1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28           28           24           11                                     
    Natural Death                                     10            6            5            8                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                      2                                     
    Terminal Sacrifice                                11           16           21           29                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (49)                                   
      Parasite Metazoan                                1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)                                   
      Parasite Metazoan                                1 (2%)       5 (10%)      3 (6%)       3 (6%)                                
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic Active                                                            1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
      Epithelium, Erosion                              1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (50)         (50)         (49)                                   
      Parasite Metazoan                                                          1 (2%)                                             
      Peyer's Patch, Inflammation, Chronic Active                                             1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)                    1 (2%)       1 (2%)                                
      Basophilic Focus                                17 (34%)     14 (28%)     20 (40%)     16 (32%)                               
      Clear Cell Focus                                 6 (12%)      2 (4%)       7 (14%)      5 (10%)                               
      Eosinophilic Focus                               2 (4%)       2 (4%)       1 (2%)       9 (18%)                               
      Hepatodiaphragmatic Nodule                                    7 (14%)      6 (12%)      8 (16%)                               
      Inflammation, Chronic                           22 (44%)     16 (32%)     22 (44%)     22 (44%)                               
      Mixed Cell Focus                                 1 (2%)                    1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                          49 (98%)     47 (94%)     46 (92%)     48 (96%)                               
      Hepatocyte, Degeneration, Cystic                16 (32%)     22 (44%)     28 (56%)     39 (78%)                               
      Hepatocyte, Necrosis                             3 (6%)                    2 (4%)       1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic           10 (20%)      3 (6%)       5 (10%)      7 (14%)                               
      Hepatocyte, Centrilobular, Degeneration          2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Hepatocyte, Centrilobular, Necrosis              2 (4%)       4 (8%)       1 (2%)       2 (4%)                                
      Kupffer Cell, Hypertrophy                        1 (2%)                                                                       
      Oval Cell, Hyperplasia                                        1 (2%)                                                          
      Portal Vein, Thrombosis                                                    1 (2%)                                             
   Mesentery                                          (15)         (12)         (15)         (11)                                   
      Accessory Spleen                                                           1 (7%)                                             
      Inflammation, Chronic Active                                                            1 (9%)                                
      Fat, Necrosis                                   12 (80%)      8 (67%)      8 (53%)      8 (73%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Oral Mucosa                                        (1)          (1)          (1)                                                 
      Gingival, Inflammation, Suppurative                                        1 (100%)                                           
      Pharyngeal, Necrosis                                          1 (100%)                                                        
   Pancreas                                           (50)         (50)         (50)         (48)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Acinus, Atrophy                                 12 (24%)     27 (54%)     16 (32%)     27 (56%)                               
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                    10 (20%)      4 (8%)       3 (6%)       2 (4%)                                
      Epithelium, Hyperplasia                          8 (16%)      8 (16%)      4 (8%)       3 (6%)                                
      Epithelium, Hyperplasia, Basal Cell                                        2 (4%)                                             
      Epithelium, Ulcer                                8 (16%)      3 (6%)       4 (8%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Mineralization                                   1 (2%)                                 1 (2%)                                
      Epithelium, Erosion                              2 (4%)       1 (2%)                    2 (4%)                                
      Epithelium, Ulcer                                1 (2%)                    1 (2%)       1 (2%)                                
   Tongue                                             (1)                       (1)          (1)                                    
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Mineralization                            1 (2%)                                 1 (2%)                                
      Pulmonary Artery, Thrombosis                     1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy, Chronic                         42 (84%)     41 (82%)     41 (82%)     44 (88%)                               
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Atrium, Thrombosis                               7 (14%)      7 (14%)      4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                                          1 (2%)       2 (4%)                                
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)       1 (2%)       1 (2%)                                             
      Degeneration, Fatty                             28 (56%)     19 (38%)     16 (32%)     20 (40%)                               
      Hyperplasia                                     13 (26%)     11 (22%)     13 (26%)     15 (30%)                               
      Hypertrophy                                                   1 (2%)       2 (4%)       4 (8%)                                
      Necrosis                                         1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Degeneration, Fatty                                           1 (2%)                                                          
      Hyperplasia                                     18 (36%)     27 (54%)     22 (44%)     25 (50%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (48)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      2 (4%)                                 1 (2%)                                
   Parathyroid Gland                                  (47)         (45)         (47)         (46)                                   
      Hyperplasia                                      9 (19%)      3 (7%)                                                          
   Pituitary Gland                                    (50)         (50)         (49)         (50)                                   
      Craniopharyngeal Duct, Cyst                      1 (2%)                                                                       
      Pars Distalis, Cyst                              7 (14%)      8 (16%)      3 (6%)       6 (12%)                               
      Pars Distalis, Hemorrhage                                                  1 (2%)                                             
      Pars Distalis, Hyperplasia                      22 (44%)     13 (26%)     15 (31%)     21 (42%)                               
      Pars Intermedia, Cyst                                         1 (2%)       3 (6%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Ectopic Tissue                                                                          1 (2%)                                
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia                             16 (32%)      8 (16%)     21 (42%)     19 (38%)                               
      Follicle, Cyst                                                1 (2%)       1 (2%)                                             
      Follicular Cell, Hyperplasia, Cystic             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)          (1)                                                              
      Inflammation, Chronic Active                     2 (100%)     1 (100%)                                                        
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                               2 (4%)                                                          
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      7 (14%)      7 (14%)      7 (14%)      4 (8%)                                
      Inflammation, Chronic Active                    42 (84%)     40 (80%)     47 (94%)     47 (94%)                               
      Duct, Cyst                                       2 (4%)                    2 (4%)                                             
   Prostate                                           (50)         (50)         (50)         (49)                                   
      Inflammation, Chronic Active                    38 (76%)     34 (68%)     32 (64%)     26 (53%)                               
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Arteriole, Inflammation, Chronic                 1 (2%)                                                                       
      Germinal Epithelium, Atrophy                     2 (4%)       2 (4%)       4 (8%)       4 (8%)                                
      Interstitial Cell, Hyperplasia                  10 (20%)     10 (20%)      6 (12%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Atrophy, Focal                                                1 (2%)                                                          
      Hyperplasia                                     30 (60%)     33 (66%)     36 (72%)     32 (64%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Myelofibrosis                                    1 (2%)       2 (4%)                    1 (2%)                                
   Lymph Node                                         (34)         (34)         (35)         (41)                                   
      Lumbar, Hyperplasia, Lymphoid                                 1 (3%)                                                          
      Mediastinal, Hyperplasia, Lymphoid                            1 (3%)       3 (9%)                                             
      Mediastinal, Necrosis                                                      1 (3%)                                             
      Mediastinal, Pigmentation, Hemosiderin          25 (74%)     19 (56%)     23 (66%)     36 (88%)                               
      Pancreatic, Ectasia                                                                     1 (2%)                                
   Lymph Node, Mandibular                             (50)         (50)         (50)         (50)                                   
      Ectasia                                                                    2 (4%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
      Ectasia                                                                    1 (2%)       2 (4%)                                
      Erythrophagocytosis                                           1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         5 (10%)      3 (6%)       3 (6%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 4 (8%)                    1 (2%)                                             
      Necrosis                                         2 (4%)                    2 (4%)       2 (4%)                                
   Thymus                                             (49)         (46)         (49)         (47)                                   
      Ectopic Parathyroid Gland                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (47)         (50)         (49)                                   
      Cyst                                                                       1 (2%)       1 (2%)                                
      Hyperplasia, Cystic                             36 (73%)     34 (72%)     24 (48%)     28 (57%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                    2 (4%)                                
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
      Epidermis, Hyperkeratosis                                     1 (2%)       3 (6%)       3 (6%)                                
      Epidermis, Hyperplasia                           1 (2%)                                                                       
      Sebaceous Gland, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Osteopetrosis                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                                                 1 (2%)                                
      Hemorrhage                                       4 (8%)                    6 (12%)      2 (4%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)                    5 (10%)      4 (8%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       5 (10%)      3 (6%)       2 (4%)                                
      Alveolus, Infiltration Cellular, Histiocyte     39 (78%)     37 (74%)     39 (78%)     40 (80%)                               
      Interstitium, Mineralization                                                            1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Fungus                                          21 (42%)     15 (30%)     10 (20%)     11 (22%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic Active                    25 (50%)     19 (38%)     22 (44%)     18 (36%)                               
      Nasolacrimal Duct, Inflammation, Suppurative     6 (12%)      6 (12%)      6 (12%)      5 (10%)                               
      Respiratory Epithelium, Hyperplasia             24 (48%)     16 (32%)     17 (34%)     13 (26%)                               
      Respiratory Epithelium, Metaplasia, Squamous    12 (24%)      9 (18%)      8 (16%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (4)          (1)          (3)                                    
      Cornea, Inflammation, Chronic Active                                       1 (100%)                                           
      Lens, Cataract                                   1 (100%)     3 (75%)                   3 (100%)                              
      Retina, Atrophy                                  1 (100%)     4 (100%)                  3 (100%)                              
      Retina, Hemorrhage                                            1 (25%)                                                         
      Sclera, Metaplasia, Osseous                                   1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                 1 (2%)                                                          
      Cyst                                             1 (2%)       4 (8%)       1 (2%)       1 (2%)                                
      Infarct                                                                    1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Nephropathy, Chronic                            50 (100%)    49 (98%)     50 (100%)    49 (98%)                               
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Pigmentation                      49 (98%)     48 (96%)     49 (98%)     50 (100%)                              
   Urinary Bladder                                    (48)         (50)         (50)         (49)                                   
      Hemorrhage                                                                              1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 08/19/97  
Route: DOSED FEED                                                                                                 Time: 10:49:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        200 PPM      400 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------