TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:30:28
27 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 010 1000 PPM
Include 001 0 PPM
Include 009 1000 PPM
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Basophilic Focus 4 (40%)
Hepatodiaphragmatic Nodule 3 (30%)
Inflammation, Chronic 10 (100%) 10 (100%)
Centrilobular, Hypertrophy 2 (20%)
Hepatocyte, Necrosis 3 (30%)
Hepatocyte, Centrilobular, Hypertrophy 6 (60%)
Pancreas (10) (10)
Acinus, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy, Chronic 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (10) (10)
Pars Distalis, Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10)
Inflammation, Chronic Active 6 (60%) 2 (20%)
Ovary (10) (10)
Cyst 1 (10%) 2 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation, Chronic Active 7 (70%) 5 (50%)
Nose (10) (10)
Inflammation, Chronic Active 4 (40%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Mineralization 10 (100%) 10 (100%)
Nephropathy, Chronic 3 (30%) 3 (30%)
Renal Tubule, Pigmentation 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Basophilic Focus 1 (10%) 1 (10%)
Hepatodiaphragmatic Nodule 1 (10%)
Inflammation, Chronic 7 (70%) 5 (50%)
Artery, Inflammation, Chronic 2 (20%)
Bile Duct, Hyperplasia 2 (20%)
Centrilobular, Hypertrophy 3 (30%)
Hepatocyte, Hypertrophy 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 8 (80%)
Hepatocyte, Centrilobular, Hypertrophy 6 (60%)
Pancreas (10) (10)
Acinus, Atrophy 2 (20%)
Acinus, Inflammation, Chronic Active 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy, Chronic 9 (90%) 10 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (10) (10)
Pars Distalis, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10)
Atrophy 1 (10%)
Inflammation, Chronic Active 1 (10%)
Preputial Gland (10) (10)
Inflammation, Chronic Active 10 (100%) 10 (100%)
Prostate (10) (10)
Inflammation, Chronic Active 5 (50%) 7 (70%)
Testes (10) (10)
Mineralization 1 (10%)
Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation, Chronic Active 7 (70%) 6 (60%)
Nose (10) (10)
Fungus 1 (10%) 1 (10%)
Inflammation, Chronic Active 6 (60%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PENTACHLOROPHENOL Date: 10/28/97
Route: DOSED FEED Time: 08:30:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Mineralization 8 (80%) 9 (90%)
Nephropathy, Chronic 10 (100%) 9 (90%)
Renal Tubule, Pigmentation 10 (100%)
Transitional Epithelium, Hyperplasia 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
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