National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6129

TDMS Study 89002-02 Pathology Tables

NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 10/28/97
Route: DOSED FEED                                                                                                 Time: 08:30:28

                                                          27 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  07/13/95

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 PPM
                               Include 010    1000 PPM
                               Include 001    0 PPM
                               Include 009    1000 PPM































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:30:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)                                                             
      Basophilic Focus                                 4 (40%)                                                                      
      Hepatodiaphragmatic Nodule                                    3 (30%)                                                         
      Inflammation, Chronic                           10 (100%)    10 (100%)                                                        
      Centrilobular, Hypertrophy                                    2 (20%)                                                         
      Hepatocyte, Necrosis                                          3 (30%)                                                         
      Hepatocyte, Centrilobular, Hypertrophy                        6 (60%)                                                         
   Pancreas                                           (10)         (10)                                                             
      Acinus, Atrophy                                  1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)                                                             
      Cardiomyopathy, Chronic                          2 (20%)      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)         (10)                                                             
      Pars Distalis, Cyst                              1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)         (10)                                                             
      Inflammation, Chronic Active                     6 (60%)      2 (20%)                                                         
   Ovary                                              (10)         (10)                                                             
      Cyst                                             1 (10%)      2 (20%)                                                         
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:30:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)                                                             
      Inflammation, Chronic Active                     7 (70%)      5 (50%)                                                         
   Nose                                               (10)         (10)                                                             
      Inflammation, Chronic Active                     4 (40%)      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)                                                             
      Mineralization                                  10 (100%)    10 (100%)                                                        
      Nephropathy, Chronic                             3 (30%)      3 (30%)                                                         
      Renal Tubule, Pigmentation                                   10 (100%)                                                        
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:30:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)                                                             
      Basophilic Focus                                 1 (10%)      1 (10%)                                                         
      Hepatodiaphragmatic Nodule                       1 (10%)                                                                      
      Inflammation, Chronic                            7 (70%)      5 (50%)                                                         
      Artery, Inflammation, Chronic                                 2 (20%)                                                         
      Bile Duct, Hyperplasia                                        2 (20%)                                                         
      Centrilobular, Hypertrophy                                    3 (30%)                                                         
      Hepatocyte, Hypertrophy                                       1 (10%)                                                         
      Hepatocyte, Vacuolization Cytoplasmic                         8 (80%)                                                         
      Hepatocyte, Centrilobular, Hypertrophy                        6 (60%)                                                         
   Pancreas                                           (10)         (10)                                                             
      Acinus, Atrophy                                  2 (20%)                                                                      
      Acinus, Inflammation, Chronic Active             2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)                                                             
      Cardiomyopathy, Chronic                          9 (90%)     10 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)         (10)                                                             
      Pars Distalis, Hyperplasia                                    1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:30:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)                                                             
      Atrophy                                                       1 (10%)                                                         
      Inflammation, Chronic Active                                  1 (10%)                                                         
   Preputial Gland                                    (10)         (10)                                                             
      Inflammation, Chronic Active                    10 (100%)    10 (100%)                                                        
   Prostate                                           (10)         (10)                                                             
      Inflammation, Chronic Active                     5 (50%)      7 (70%)                                                         
   Testes                                             (10)         (10)                                                             
      Mineralization                                                1 (10%)                                                         
      Necrosis                                                      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)                                                             
      Inflammation, Chronic Active                     7 (70%)      6 (60%)                                                         
   Nose                                               (10)         (10)                                                             
      Fungus                                           1 (10%)      1 (10%)                                                         
      Inflammation, Chronic Active                     6 (60%)      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 89002-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PENTACHLOROPHENOL                                     Date: 10/28/97  
Route: DOSED FEED                                                                                                 Time: 08:30:28  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        1000 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)                                                             
      Mineralization                                   8 (80%)      9 (90%)                                                         
      Nephropathy, Chronic                            10 (100%)     9 (90%)                                                         
      Renal Tubule, Pigmentation                                   10 (100%)                                                        
      Transitional Epithelium, Hyperplasia                          1 (10%)                                                         
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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