TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 Facility: Battelle Columbus Laboratory Chemical CAS #: 87-86-5 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 1| 1| 1| 7| 1| 7| 1| 5| 7| 1| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 0| 6| 9| 8| 8| 8| 3| 8| 3| 8| 4| 3| 8| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| | 4| 3| 6| 4| 4| 4| 8| 4| 9| 4| 4| 9| 4| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | | Schwannoma Malignant, Metastatic, | | Uterus | X | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 1| 1| 1| 7| 1| 7| 1| 5| 7| 1| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 0| 6| 9| 8| 8| 8| 3| 8| 3| 8| 4| 3| 8| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| | 4| 3| 6| 4| 4| 4| 8| 4| 9| 4| 4| 9| 4| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + M + + +| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Pars Distalis, Adenoma | X X X X X X X X X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 1| 1| 1| 7| 1| 7| 1| 5| 7| 1| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 0| 6| 9| 8| 8| 8| 3| 8| 3| 8| 4| 3| 8| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| | 4| 3| 6| 4| 4| 4| 8| 4| 9| 4| 4| 9| 4| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | Leukemia Mononuclear | X| Bilateral, Carcinoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Polyp Stromal | X | Schwannoma Malignant, Metastatic, | | Uterus | X | |__________________________________________________________________________| Vagina | + + | Schwannoma Malignant, Metastatic, | | Uterus | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + +| Inguinal, Leukemia Mononuclear | X | Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X| Renal, Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 1| 1| 1| 7| 1| 7| 1| 5| 7| 1| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 0| 6| 9| 8| 8| 8| 3| 8| 3| 8| 4| 3| 8| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| | 4| 3| 6| 4| 4| 4| 8| 4| 9| 4| 4| 9| 4| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Leukemia | | Mononuclear | X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 1| 1| 1| 7| 1| 7| 1| 5| 7| 1| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 0| 6| 9| 8| 8| 8| 3| 8| 3| 8| 4| 3| 8| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| | 4| 3| 6| 4| 4| 4| 8| 4| 9| 4| 4| 9| 4| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 6| 5| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 1| 6| 7| 7| 7| 1| DAY ON TEST | 4| 3| 3| 8| 6| 9| 7| 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 8| 9| 3| 3| 3| 8| | 0| 8| 9| 4| 1| 8| 3| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 4| 8| 9| 8| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | X X | Schwannoma Malignant, Metastatic, | | Uterus | | |__________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 6| 5| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 1| 6| 7| 7| 7| 1| DAY ON TEST | 4| 3| 3| 8| 6| 9| 7| 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 8| 9| 3| 3| 3| 8| | 0| 8| 9| 4| 1| 8| 3| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 4| 8| 9| 8| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + M + M + + + M + + + + + + + + + + + + + + M + +| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 8 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 6| 5| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 1| 6| 7| 7| 7| 1| DAY ON TEST | 4| 3| 3| 8| 6| 9| 7| 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 8| 9| 3| 3| 3| 8| | 0| 8| 9| 4| 1| 8| 3| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 4| 8| 9| 8| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | Leukemia Mononuclear | X | Bilateral, Carcinoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X | Schwannoma Malignant, Metastatic, | | Uterus | | |__________________________________________________________________________| Vagina | | Schwannoma Malignant, Metastatic, | | Uterus | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + | Inguinal, Leukemia Mononuclear | X | Lumbar, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X X X | Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 6| 5| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 1| 6| 7| 7| 7| 1| DAY ON TEST | 4| 3| 3| 8| 6| 9| 7| 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 8| 9| 3| 3| 3| 8| | 0| 8| 9| 4| 1| 8| 3| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 4| 8| 9| 8| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 6| 5| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 1| 6| 7| 7| 7| 1| DAY ON TEST | 4| 3| 3| 8| 6| 9| 7| 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 8| 9| 3| 3| 3| 8| | 0| 8| 9| 4| 1| 8| 3| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 4| 8| 9| 8| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 PPM | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 1| 7| 7| 7| 7| 7| 5| 7| 6| | | DAY ON TEST | 2| 8| 4| 3| 3| 3| 4| 4| 3| 6| | | | 0| 4| 0| 8| 9| 1| 0| 3| 8| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 14 | |__________________________________________________________________________|____________| Mesentery | + | 8 | Leukemia Mononuclear | | 2 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 1| 7| 7| 7| 7| 7| 5| 7| 6| | | DAY ON TEST | 2| 8| 4| 3| 3| 3| 4| 4| 3| 6| | | | 0| 4| 0| 8| 9| 1| 0| 3| 8| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Leukemia Mononuclear | | 3 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 7 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 7 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 54 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 6 | Pars Distalis, Adenoma | X X X X | 22 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 1| 7| 7| 7| 7| 7| 5| 7| 6| | | DAY ON TEST | 2| 8| 4| 3| 3| 3| 4| 4| 3| 6| | | | 0| 4| 0| 8| 9| 1| 0| 3| 8| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pars Intermedia, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | C-Cell, Adenoma | | 3 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 60 | Adenoma | | 4 | Carcinoma | | 1 | Leukemia Mononuclear | | 2 | Bilateral, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Polyp Stromal | X | 6 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | |__________________________________________________________________________|____________| Vagina | | 2 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 1| 7| 7| 7| 7| 7| 5| 7| 6| | | DAY ON TEST | 2| 8| 4| 3| 3| 3| 4| 4| 3| 6| | | | 0| 4| 0| 8| 9| 1| 0| 3| 8| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + + | 35 | Inguinal, Leukemia Mononuclear | | 2 | Lumbar, Leukemia Mononuclear | | 1 | Mediastinal, Leukemia Mononuclear | | 7 | Renal, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 6 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 9 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 15 | |__________________________________________________________________________|____________| Thymus | + + + + M + + + + + | 58 | Leukemia Mononuclear | | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | Carcinoma | | 1 | Fibroadenoma | X X | 16 | Fibroadenoma, Multiple | X X X | 9 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Fibroma | X | 2 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Leukemia | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 1| 7| 7| 7| 7| 7| 5| 7| 6| | | DAY ON TEST | 2| 8| 4| 3| 3| 3| 4| 4| 3| 6| | | | 0| 4| 0| 8| 9| 1| 0| 3| 8| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | X | 14 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 11 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 1| 7| 7| 7| 7| 7| 5| 7| 6| | | DAY ON TEST | 2| 8| 4| 3| 3| 3| 4| 4| 3| 6| | | | 0| 4| 0| 8| 9| 1| 0| 3| 8| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 0 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Leukemia Mononuclear | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 2| 9| 3| 3| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 3| | 6| 9| 0| 1| 8| 8| 4| 8| 2| 8| 0| 8| 9| 8| 9| 0| 8| 9| 0| 5| 0| 9| 0| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 200 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Mesentery | | |__________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 2| 9| 3| 3| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 3| | 6| 9| 0| 1| 8| 8| 4| 8| 2| 8| 0| 8| 9| 8| 9| 0| 8| 9| 0| 5| 0| 9| 0| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 200 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X| Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | Leukemia Mononuclear | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 2| 9| 3| 3| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 3| | 6| 9| 0| 1| 8| 8| 4| 8| 2| 8| 0| 8| 9| 8| 9| 0| 8| 9| 0| 5| 0| 9| 0| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 200 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Leukemia Mononuclear | | Polyp Stromal | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + | Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | X | Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X | Pancreatic, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Thymus | + + + + + M + + + + M + + + + + M + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 20 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 2| 9| 3| 3| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 3| | 6| 9| 0| 1| 8| 8| 4| 8| 2| 8| 0| 8| 9| 8| 9| 0| 8| 9| 0| 5| 0| 9| 0| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 200 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Fibroma | X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + | |__________________________________________________________________________| Zymbal's Gland | +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| | DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| | | 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 14 | |__________________________________________________________________________|____________| Mesentery | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| | DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| | | 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | | | | Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 10 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X | 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M M + + + + + + + + + + + + + M + + M| 44 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 7 | Pars Distalis, Adenoma | X X X X X X X | 20 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X | 3 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| | DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| | | 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Carcinoma | | 1 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Polyp Stromal | X X | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 5 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + +| 27 | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | | 1 | Lumbar, Leukemia Mononuclear | X| 1 | Mediastinal, Leukemia Mononuclear | X X X X X| 9 | Pancreatic, Leukemia Mononuclear | X| 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X| 7 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| | DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| | | 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + M + + + + + + + + + M| 44 | Leukemia Mononuclear | X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X X| 2 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X X X X X X X X | 17 | Fibroadenoma, Multiple | X X | 3 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 12 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| | DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| | | 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 3 | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 11 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4| | 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + | Carcinoma, Metastatic, Intestine | | Small, Jejunum | X | Leukemia Mononuclear | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Intestine | | Small, Jejunum | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Intestine | | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4| | 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Small, Jejunum | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Intestine | | Small, Jejunum | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + M + + + M + + + + M + M M + + M + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4| | 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Adenoma | | Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Leukemia Mononuclear | X X | Thecoma Malignant | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Polyp Stromal | X X | Sarcoma Stromal | X | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + +| Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | X | Inguinal, Leukemia Mononuclear | X | Mediastinal, Carcinoma, Metastatic, | | Intestine Small, Jejunum | X | Mediastinal, Leukemia Mononuclear | X X X X | Pancreatic, Carcinoma, Metastatic, | | Intestine Small, Jejunum | X | Pancreatic, Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4| | 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X| Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Vertebra, Fibrosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + + | Carcinoma, Metastatic, Intestine | | Small, Jejunum | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4| | 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Intestine | | Small, Jejunum | X | Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| | | 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 15 | |__________________________________________________________________________|____________| Mesentery | + + | 5 | Carcinoma, Metastatic, Intestine | | | Small, Jejunum | | 1 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Intestine | | | Small, Jejunum | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| | | 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Intestine | | | Small, Jejunum | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Intestine | | | Small, Jejunum | | 1 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 7 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 7 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | M M + + + + + M + + + + + + + + + + + + + + + + +| 41 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Pars Distalis, Adenoma | X X X X X | 14 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| | | 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | | 1 | C-Cell, Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X | 1 | Carcinoma | X | 2 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Benign | X | 1 | Leukemia Mononuclear | X | 3 | Thecoma Malignant | X | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | Polyp Stromal | X | 3 | Sarcoma Stromal | | 1 | |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 7 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + +| 26 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| | | 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | | 1 | Inguinal, Leukemia Mononuclear | | 1 | Mediastinal, Carcinoma, Metastatic, | | | Intestine Small, Jejunum | | 1 | Mediastinal, Leukemia Mononuclear | X X | 6 | Pancreatic, Carcinoma, Metastatic, | | | Intestine Small, Jejunum | | 1 | Pancreatic, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 15 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma | X | 2 | Fibroadenoma | X X X X X X X X X X| 18 | Fibroadenoma, Multiple | | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| | | 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vertebra, Fibrosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | | 2 | Carcinoma, Metastatic, Intestine | | | Small, Jejunum | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Intestine | | | Small, Jejunum | | 1 | Leukemia Mononuclear | X X X X X X | 13 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 2 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| | | 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 11 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7| DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4| | 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | X X | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7| DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4| | 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X | Pars Distalis, Adenoma, Multiple | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7| DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4| | 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | |__________________________________________________________________________| Tissue NOS | + | Abdominal, Paraganglioma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X | Bilateral, Adenoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | X | Leiomyosarcoma, Metastatic, Uterus | | Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | Leukemia Mononuclear | | Polyp Stromal | X X | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + | Deep Cervical, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | | Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X | Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 40 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7| DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4| | 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Fibroadenoma | X X X X X | Fibroadenoma, Multiple | | Leukemia Mononuclear | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7| DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4| | 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Ureter | + | Carcinoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| | | 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 18 | |__________________________________________________________________________|____________| Mesentery | + + | 5 | Leukemia Mononuclear | X X | 4 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| | | 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 11 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X X X | 13 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 13 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 9 | Pars Distalis, Adenoma | X X X X X| 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| | | 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma, Multiple | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Bilateral, C-Cell, Adenoma | X | 1 | C-Cell, Adenoma | | 3 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 1 | Abdominal, Paraganglioma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Leukemia Mononuclear | X | 2 | Bilateral, Adenoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Benign | | 1 | Leiomyosarcoma, Metastatic, Uterus | X | 1 | Leukemia Mononuclear | X X X | 7 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyosarcoma | X | 1 | Leukemia Mononuclear | X X | 2 | Polyp Stromal | X X | 4 | Sarcoma Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| | | 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X | 6 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + +| 28 | Deep Cervical, Leukemia Mononuclear | X | 1 | Inguinal, Leukemia Mononuclear | X | 1 | Lumbar, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X X X X X | 9 | Renal, Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 13 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 18 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + M + + + M + + + + + +| 47 | Leukemia Mononuclear | X X X | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Fibroadenoma | X X X X X X | 11 | Fibroadenoma, Multiple | X | 1 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| | | 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 17 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| | | 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 16 | |__________________________________________________________________________|____________| Ureter | | 1 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X | 18 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 1| 7| 5| 1| 1| 6| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 4| 4| 6| 8| 3| 1| 8| 8| 0| 8| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| | 8| 9| 0| 0| 5| 4| 9| 6| 4| 4| 0| 4| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 1000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Sarcoma Stromal, Metastatic, Uterus | X | |__________________________________________________________________________| Mesentery | + + | Leukemia Mononuclear | X | Fat, Sarcoma Stromal, Metastatic, | | Uterus | X | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Sarcoma Stromal, Metastatic, Uterus | X | Acinus, Adenoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 1| 7| 5| 1| 1| 6| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 4| 4| 6| 8| 3| 1| 8| 8| 0| 8| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| | 8| 9| 0| 0| 5| 4| 9| 6| 4| 4| 0| 4| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 1000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Parathyroid Gland | + M + + + + M M M + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 1| 7| 5| 1| 1| 6| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 4| 4| 6| 8| 3| 1| 8| 8| 0| 8| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| | 8| 9| 0| 0| 5| 4| 9| 6| 4| 4| 0| 4| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 1000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + +| Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | | Mediastinal, Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 1| 7| 5| 1| 1| 6| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 4| 4| 6| 8| 3| 1| 8| 8| 0| 8| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| | 8| 9| 0| 0| 5| 4| 9| 6| 4| 4| 0| 4| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 1000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X | Sarcoma Stromal, Metastatic, Uterus | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Cranial Nerve, Squamous Cell | | Carcinoma, Metastatic, Oral | | Mucosa | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 1| 7| 5| 1| 1| 6| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 4| 4| 6| 8| 3| 1| 8| 8| 0| 8| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| | 8| 9| 0| 0| 5| 4| 9| 6| 4| 4| 0| 4| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 1000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Clitoral Gland| | Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | |__________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________|__________________________________________________________________________| Page 53 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 0| 5| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 6| 1| 4| 1| 7| DAY ON TEST | 4| 6| 5| 4| 3| 1| 7| 3| 8| 4| 3| 3| 3| 2| 3| 4| 1| 1| 8| 8| 0| 8| 7| 8| 3| | 0| 8| 2| 0| 9| 1| 1| 8| 4| 0| 9| 8| 9| 4| 8| 0| 9| 9| 4| 4| 0| 4| 2| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Sarcoma Stromal, Metastatic, Uterus | | |__________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | X | Fat, Sarcoma Stromal, Metastatic, | | Uterus | | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Sarcoma Stromal, Metastatic, Uterus | | Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 0| 5| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 6| 1| 4| 1| 7| DAY ON TEST | 4| 6| 5| 4| 3| 1| 7| 3| 8| 4| 3| 3| 3| 2| 3| 4| 1| 1| 8| 8| 0| 8| 7| 8| 3| | 0| 8| 2| 0| 9| 1| 1| 8| 4| 0| 9| 8| 9| 4| 8| 0| 9| 9| 4| 4| 0| 4| 2| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 0| 5| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 6| 1| 4| 1| 7| DAY ON TEST | 4| 6| 5| 4| 3| 1| 7| 3| 8| 4| 3| 3| 3| 2| 3| 4| 1| 1| 8| 8| 0| 8| 7| 8| 3| | 0| 8| 2| 0| 9| 1| 1| 8| 4| 0| 9| 8| 9| 4| 8| 0| 9| 9| 4| 4| 0| 4| 2| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | X X | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + | Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | | Mediastinal, Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 0| 5| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 6| 1| 4| 1| 7| DAY ON TEST | 4| 6| 5| 4| 3| 1| 7| 3| 8| 4| 3| 3| 3| 2| 3| 4| 1| 1| 8| 8| 0| 8| 7| 8| 3| | 0| 8| 2| 0| 9| 1| 1| 8| 4| 0| 9| 8| 9| 4| 8| 0| 9| 9| 4| 4| 0| 4| 2| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X | Sarcoma Stromal, Metastatic, Uterus | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X| Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Leukemia | | Mononuclear | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Cranial Nerve, Squamous Cell | | Carcinoma, Metastatic, Oral | | Mucosa | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 0| 5| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 6| 1| 4| 1| 7| DAY ON TEST | 4| 6| 5| 4| 3| 1| 7| 3| 8| 4| 3| 3| 3| 2| 3| 4| 1| 1| 8| 8| 0| 8| 7| 8| 3| | 0| 8| 2| 0| 9| 1| 1| 8| 4| 0| 9| 8| 9| 4| 8| 0| 9| 9| 4| 4| 0| 4| 2| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Clitoral Gland| X | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | |__________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| | | DAY ON TEST | 4| 3| 4| 8| 0| 3| 9| 3| 3| 4| | | | 0| 9| 0| 4| 4| 8| 2| 9| 8| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Leiomyoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 11 | Sarcoma Stromal, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Mesentery | + | 6 | Leukemia Mononuclear | | 2 | Fat, Sarcoma Stromal, Metastatic, | | | Uterus | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 2 | Pharyngeal, Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| | | DAY ON TEST | 4| 3| 4| 8| 0| 3| 9| 3| 3| 4| | | | 0| 9| 0| 4| 4| 8| 2| 9| 8| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Sarcoma Stromal, Metastatic, Uterus | | 1 | Acinus, Adenoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 8 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 8 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| | | DAY ON TEST | 4| 3| 4| 8| 0| 3| 9| 3| 3| 4| | | | 0| 9| 0| 4| 4| 8| 2| 9| 8| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + I + + + + + | 53 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 5 | Pars Distalis, Adenoma | X X | 18 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Bilateral, C-Cell, Adenoma | X | 2 | C-Cell, Adenoma | X | 5 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 59 | Adenoma | X X | 5 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 4 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Polyp Stromal | | 6 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| | | DAY ON TEST | 4| 3| 4| 8| 0| 3| 9| 3| 3| 4| | | | 0| 9| 0| 4| 4| 8| 2| 9| 8| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Bone Marrow | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 3 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + | 30 | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | X | 1 | Mediastinal, Leukemia Mononuclear | | 8 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 6 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 10 | Sarcoma Stromal, Metastatic, Uterus | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 11 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | Fibroadenoma | | 10 | Fibroadenoma, Multiple | X | 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| | | DAY ON TEST | 4| 3| 4| 8| 0| 3| 9| 3| 3| 4| | | | 0| 9| 0| 4| 4| 8| 2| 9| 8| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 2 | Cranial Nerve, Squamous Cell | | | Carcinoma, Metastatic, Oral | | | Mucosa | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Clitoral Gland| | 1 | Leukemia Mononuclear | X | 10 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 2 | |__________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| | | DAY ON TEST | 4| 3| 4| 8| 0| 3| 9| 3| 3| 4| | | | 0| 9| 0| 4| 4| 8| 2| 9| 8| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 1000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 10 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 59 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 1| 7| 1| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 8| 3| 8| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 4| 6| 4| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Mesothelioma Malignant | | |__________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | | Fat, Sarcoma | | |__________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Papilloma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Acinus, Adenoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 1| 7| 1| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 8| 3| 8| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 4| 6| 4| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Tongue | +| Squamous Cell Papilloma | X| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | X X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + M + M + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 1| 7| 1| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 8| 3| 8| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 4| 6| 4| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | | C-Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + + | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 1| 7| 1| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 8| 3| 8| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 4| 6| 4| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X X X | Mediastinal, Sarcoma, Metastatic, | | Mesentery | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Mesothelioma Malignant | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibroma, | | Multiple | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Fibrous | | Histiocytoma | X | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 1| 7| 1| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 8| 3| 8| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 4| 6| 4| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Vertebra, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Renal Tubule, Adenoma | X | |__________________________________________________________________________| Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Transitional Epithelium, Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | | __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 1| 7| 7| 5| 6| 6| 7| 1| 1| 7| 6| 4| 7| 1| 6| 7| 7| 4| 7| 6| 7| 1| 6| 1| 6| DAY ON TEST | 8| 3| 3| 9| 8| 8| 3| 8| 8| 3| 9| 3| 3| 8| 6| 3| 2| 2| 3| 9| 3| 8| 4| 8| 4| | 4| 6| 6| 3| 1| 4| 6| 4| 4| 6| 8| 5| 3| 4| 0| 7| 9| 0| 7| 8| 7| 4| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Mesothelioma Malignant | | |__________________________________________________________________________| Mesentery | + + + + + + +| Leukemia Mononuclear | X| Mesothelioma Malignant | | Fat, Sarcoma | | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Acinus, Adenoma | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 1| 7| 7| 5| 6| 6| 7| 1| 1| 7| 6| 4| 7| 1| 6| 7| 7| 4| 7| 6| 7| 1| 6| 1| 6| DAY ON TEST | 8| 3| 3| 9| 8| 8| 3| 8| 8| 3| 9| 3| 3| 8| 6| 3| 2| 2| 3| 9| 3| 8| 4| 8| 4| | 4| 6| 6| 3| 1| 4| 6| 4| 4| 6| 8| 5| 3| 4| 0| 7| 9| 0| 7| 8| 7| 4| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Pheochromocytoma Malignant | | Pheochromocytoma Complex | | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X X| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | M + + + + + + M M + + + + M + + + + + + + + + M +| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Pars Distalis, Adenoma | X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 1| 7| 7| 5| 6| 6| 7| 1| 1| 7| 6| 4| 7| 1| 6| 7| 7| 4| 7| 6| 7| 1| 6| 1| 6| DAY ON TEST | 8| 3| 3| 9| 8| 8| 3| 8| 8| 3| 9| 3| 3| 8| 6| 3| 2| 2| 3| 9| 3| 8| 4| 8| 4| | 4| 6| 6| 3| 1| 4| 6| 4| 4| 6| 8| 5| 3| 4| 0| 7| 9| 0| 7| 8| 7| 4| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | | C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Mesothelioma Malignant | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | Leukemia Mononuclear | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 1| 7| 7| 5| 6| 6| 7| 1| 1| 7| 6| 4| 7| 1| 6| 7| 7| 4| 7| 6| 7| 1| 6| 1| 6| DAY ON TEST | 8| 3| 3| 9| 8| 8| 3| 8| 8| 3| 9| 3| 3| 8| 6| 3| 2| 2| 3| 9| 3| 8| 4| 8| 4| | 4| 6| 6| 3| 1| 4| 6| 4| 4| 6| 8| 5| 3| 4| 0| 7| 9| 0| 7| 8| 7| 4| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X X X X X| Mediastinal, Sarcoma, Metastatic, | | Mesentery | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Mesothelioma Malignant | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Fibroadenoma | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibroma, | | Multiple | | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Fibrous | | Histiocytoma | | _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 1| 7| 7| 5| 6| 6| 7| 1| 1| 7| 6| 4| 7| 1| 6| 7| 7| 4| 7| 6| 7| 1| 6| 1| 6| DAY ON TEST | 8| 3| 3| 9| 8| 8| 3| 8| 8| 3| 9| 3| 3| 8| 6| 3| 2| 2| 3| 9| 3| 8| 4| 8| 4| | 4| 6| 6| 3| 1| 4| 6| 4| 4| 6| 8| 5| 3| 4| 0| 7| 9| 0| 7| 8| 7| 4| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Vertebra, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Renal Tubule, Adenoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant | | Transitional Epithelium, Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Mesothelioma Malignant | | __________________________________________|__________________________________________________________________________| Page 74 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 1| 6| 6| 6| 3| 1| 7| 6| 6| | | DAY ON TEST | 3| 8| 9| 0| 1| 9| 8| 2| 7| 0| | | | 7| 4| 0| 0| 7| 6| 4| 2| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 24 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + | 15 | Leukemia Mononuclear | X X | 4 | Mesothelioma Malignant | X | 1 | Fat, Sarcoma | X | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | Acinus, Adenoma | | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 1| 6| 6| 6| 3| 1| 7| 6| 6| | | DAY ON TEST | 3| 8| 9| 0| 1| 9| 8| 2| 7| 0| | | | 7| 4| 0| 0| 7| 6| 4| 2| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Salivary Glands | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 12 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 12 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | | 7 | Bilateral, Pheochromocytoma Benign | | 7 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 1| 6| 6| 6| 3| 1| 7| 6| 6| | | DAY ON TEST | 3| 8| 9| 0| 1| 9| 8| 2| 7| 0| | | | 7| 4| 0| 0| 7| 6| 4| 2| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Parathyroid Gland | + + + M + + + + M + | 50 | Adenoma | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 13 | Pars Distalis, Adenoma | X | 18 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 1 | C-Cell, Adenoma | X | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | | 2 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 60 | Adenoma | X | 4 | Carcinoma | X | 1 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 1| 6| 6| 6| 3| 1| 7| 6| 6| | | DAY ON TEST | 3| 8| 9| 0| 1| 9| 8| 2| 7| 0| | | | 7| 4| 0| 0| 7| 6| 4| 2| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 2 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X | 34 | Interstitial Cell, Adenoma | X | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 9 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + | 34 | Lumbar, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X X | 16 | Mediastinal, Sarcoma, Metastatic, | | | Mesentery | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 13 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 19 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 24 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 59 | Leukemia Mononuclear | X X | 7 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 1| 6| 6| 6| 3| 1| 7| 6| 6| | | DAY ON TEST | 3| 8| 9| 0| 1| 9| 8| 2| 7| 0| | | | 7| 4| 0| 0| 7| 6| 4| 2| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 59 | Fibroadenoma | X | 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basal Cell Adenoma | | 1 | Squamous Cell Papilloma | | 2 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibroma, | | | Multiple | X | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 2 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Vertebra, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 25 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 79 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 7| 1| 6| 6| 6| 3| 1| 7| 6| 6| | | DAY ON TEST | 3| 8| 9| 0| 1| 9| 8| 2| 7| 0| | | | 7| 4| 0| 0| 7| 6| 4| 2| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 24 | Renal Tubule, Adenoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 58 | Leukemia Mononuclear | X X | 4 | Mesothelioma Malignant | X | 1 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X | 25 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7| DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0| | 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Adenomatous | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Adenomatous | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Leukemia Mononuclear | X X X X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + + + + + + | Leukemia Mononuclear | X X | Lipoma | | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 81 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7| DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0| | 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X X X X X X X X X| Bilateral, Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + M + + + + + M + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| Pars Distalis, Adenoma | X X X X X X X X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X | __________________________________________|__________________________________________________________________________| Page 82 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7| DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0| | 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Carcinoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X X X | Leukemia Mononuclear | | Bilateral, Adenoma | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + +| Deep Cervical, Leukemia Mononuclear | | __________________________________________|__________________________________________________________________________| Page 83 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7| DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0| | 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X X X X X X X X X| Pancreatic, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + M + + + + + M + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 84 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7| DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0| | 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Skeletal Muscle | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Thyroid Gland | | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X X X X X X X X X X| Mediastinum, Hemangiosarcoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X X X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X X X X X X X X X X X| Renal Tubule, Adenoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 85 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7| DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0| | 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 86 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| | | 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Adenomatous | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Polyp Adenomatous | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X| 26 | |__________________________________________________________________________|____________| Mesentery | + + + +| 12 | Leukemia Mononuclear | X| 3 | Lipoma | X | 1 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 5 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| | | 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X| 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 14 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 12 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 13 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | X X X X X X X X | 17 | Bilateral, Pheochromocytoma Benign | X X X X | 4 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + M + +| 45 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 88 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| | | 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 17 | Pars Distalis, Adenoma | X X X X X X X X | 16 | Pars Intermedia, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X| 8 | C-Cell, Carcinoma | X X | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X X X | 7 | Leukemia Mononuclear | X| 1 | Bilateral, Adenoma | | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 89 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| | | 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X| 35 | Interstitial Cell, Adenoma | X X X X X | 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 10 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 34 | Deep Cervical, Leukemia Mononuclear | X | 1 | Lumbar, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X X X X X X X X X X| 22 | Pancreatic, Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 17 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Leukemia Mononuclear | X X X X X X X X X X| 21 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X| 26 | |__________________________________________________________________________|____________| Thymus | + + + + M + + + + + + + + + M + M + + + + + + + +| 46 | Leukemia Mononuclear | X X X X X| 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 90 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| | | 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 | Carcinoma | X | 1 | Fibroadenoma | X X X| 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 2 | Squamous Cell Papilloma | X | 1 | Subcutaneous Tissue, Fibroma | X | 2 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | X | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 2 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 91 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| | | 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X X X| 25 | Mediastinum, Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | | 3 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Skin | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X| 25 | Renal Tubule, Adenoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 4 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X| 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 92 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6| DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2| | 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | X | Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + + + + + + + + +| Leukemia Mononuclear | X X X| Mesothelioma Malignant | X | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Squamous Cell Carcinoma | X | __________________________________________|__________________________________________________________________________| Page 93 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6| DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2| | 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Leukemia Mononuclear | X| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Liver | X | Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X X X | Bilateral, Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| Pars Distalis, Adenoma | X X X X X X X | __________________________________________|__________________________________________________________________________| Page 94 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6| DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2| | 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma, Multiple | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Leukemia Mononuclear | X| Mesothelioma Malignant | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 95 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6| DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2| | 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Liver | X | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + +| Inguinal, Leukemia Mononuclear | X | Lumbar, Leukemia Mononuclear | X X X | Mediastinal, Fibrous Histiocytoma, | | Metastatic, Liver | X | Mediastinal, Leukemia Mononuclear | X X X X X X X X X| Pancreatic, Leukemia Mononuclear | X| Renal, Leukemia Mononuclear | X | Renal, Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Liver | X | Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Liver | X | Leukemia Mononuclear | X X X X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Liver | X | Leukemia Mononuclear | X X X X X X X X X X X X X| Mesothelioma Malignant | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Liver | X | Leukemia Mononuclear | X X X X| __________________________________________|__________________________________________________________________________| Page 96 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6| DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2| | 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Fibrous Histiocytoma, Metastatic, | | Liver | X | Keratoacanthoma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Vertebra, Chordoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Leukemia Mononuclear | X| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Chordoma, Metastatic, Bone | X | __________________________________________|__________________________________________________________________________| Page 97 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6| DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2| | 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Fibrous Histiocytoma, Metastatic, | | Liver | X | Leukemia Mononuclear | X X X X X X X X X X X X| Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | |__________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Liver | X | Leukemia Mononuclear | X X X X X X X X X X X X| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Mesothelioma Malignant | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| Page 98 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| | DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| | | 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Peyer's Patch, Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma | | 1 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X | 26 | |__________________________________________________________________________|____________| Mesentery | + + + + | 15 | Leukemia Mononuclear | X | 4 | Mesothelioma Malignant | X | 2 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | Acinus, Adenoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 99 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| | DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| | | 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Leukemia Mononuclear | X X X X X X X X X | 14 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 16 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 16 | Pheochromocytoma Malignant | X X | 3 | Pheochromocytoma Benign | X X X X X X X X X | 17 | Bilateral, Pheochromocytoma Benign | X | 3 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 100 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| | DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| | | 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + + + + + + + M + + + + + M + +| 47 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X | 13 | Pars Distalis, Adenoma | X X X X X X | 13 | Pars Distalis, Adenoma, Multiple | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X | 7 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 2 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 3 | Carcinoma | X| 1 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | Leukemia Mononuclear | X X X | 4 | Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 101 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| | DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| | | 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X | 42 | Interstitial Cell, Adenoma | X X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Leukemia Mononuclear | X X X X X | 10 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + | 35 | Inguinal, Leukemia Mononuclear | | 1 | Lumbar, Leukemia Mononuclear | | 3 | Mediastinal, Fibrous Histiocytoma, | | | Metastatic, Liver | | 1 | Mediastinal, Leukemia Mononuclear | X X X X X X X X | 17 | Pancreatic, Leukemia Mononuclear | X X X | 4 | Renal, Leukemia Mononuclear | X X | 3 | Renal, Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Leukemia Mononuclear | X X X X X X X | 13 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 102 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| | DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| | | 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 21 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X | 26 | Mesothelioma Malignant | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Leukemia Mononuclear | X X X X X X X | 11 | Thymoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | X X X | 4 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | X | 1 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Keratoacanthoma | X | 1 | Subcutaneous Tissue, Fibroma | X | 2 | Subcutaneous Tissue, Leukemia | | | Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 103 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| | DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| | | 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vertebra, Chordoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | X | 1 | Leukemia Mononuclear | X X X X X | 6 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | | 1 | Chordoma, Metastatic, Bone | | 1 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 23 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 104 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| | DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| | | 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 23 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 26 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 105 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| DAY ON TEST | 0| 3| 3| 3| 0| 0| 4| 1| 3| 6| 3| 1| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 1| | 8| 7| 6| 7| 8| 2| 4| 0| 7| 0| 6| 2| 7| 7| 7| 0| 7| 7| 1| 6| 6| 7| 6| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Osteosarcoma, Metastatic, Spleen | X | |__________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X | Fat, Osteosarcoma, Metastatic, Spleen| X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Osteosarcoma, Metastatic, Spleen | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Osteosarcoma, Metastatic, Spleen | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 106 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| DAY ON TEST | 0| 3| 3| 3| 0| 0| 4| 1| 3| 6| 3| 1| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 1| | 8| 7| 6| 7| 8| 2| 4| 0| 7| 0| 6| 2| 7| 7| 7| 0| 7| 7| 1| 6| 6| 7| 6| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tongue | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + M + + + + + + M + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| Pars Distalis, Adenoma | X X X X X X | Pars Distalis, Carcinoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | | __________________________________________|__________________________________________________________________________| Page 107 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| DAY ON TEST | 0| 3| 3| 3| 0| 0| 4| 1| 3| 6| 3| 1| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 1| | 8| 7| 6| 7| 8| 2| 4| 0| 7| 0| 6| 2| 7| 7| 7| 0| 7| 7| 1| 6| 6| 7| 6| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + | Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | | Inguinal, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X X X X X X X | Mediastinal, Osteosarcoma, | | Metastatic, Spleen | X | Pancreatic, Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| Page 108 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| DAY ON TEST | 0| 3| 3| 3| 0| 0| 4| 1| 3| 6| 3| 1| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 1| | 8| 7| 6| 7| 8| 2| 4| 0| 7| 0| 6| 2| 7| 7| 7| 0| 7| 7| 1| 6| 6| 7| 6| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Osteosarcoma, Metastatic, Spleen | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Osteosarcoma | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X X| Squamous Cell Papilloma | X X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Osteosarcoma, Metastatic, Spleen | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 109 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5| DAY ON TEST | 0| 3| 3| 3| 0| 0| 4| 1| 3| 6| 3| 1| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 1| | 8| 7| 6| 7| 8| 2| 4| 0| 7| 0| 6| 2| 7| 7| 7| 0| 7| 7| 1| 6| 6| 7| 6| 7| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Astrocytoma Malignant | X | Carcinoma, Metastatic, Pituitary | | Gland | | Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Squamous Cell Carcinoma | | Mediastinum, Squamous Cell Carcinoma,| | Metastatic, Lung | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | |__________________________________________________________________________| Zymbal's Gland | + | Adenoma | X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Renal Tubule, Carcinoma | X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Transitional Epithelium, Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 110 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 1| 3| 1| 3| 3| 3| 0| 3| 3| 3| 0| 3| 0| 2| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| | | 4| 7| 3| 7| 7| 6| 9| 7| 6| 7| 5| 6| 7| 1| 7| 1| 6| 6| 7| 7| 9| 7| 7| 7| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 600 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 23 | Osteosarcoma, Metastatic, Spleen | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + +| 11 | Leukemia Mononuclear | X X| 3 | Fat, Osteosarcoma, Metastatic, Spleen| | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | Leukemia Mononuclear | X X X X | 5 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Osteosarcoma, Metastatic, Spleen | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 111 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 1| 3| 1| 3| 3| 3| 0| 3| 3| 3| 0| 3| 0| 2| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| | | 4| 7| 3| 7| 7| 6| 9| 7| 6| 7| 5| 6| 7| 1| 7| 1| 6| 6| 7| 7| 9| 7| 7| 7| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 600 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Osteosarcoma, Metastatic, Spleen | | 1 | |__________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X| 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 15 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 13 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X X X X X X | 12 | Bilateral, Pheochromocytoma Benign | X X X X X X | 11 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | Adenoma | | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + + M + + + + + + + + + +| 46 | Adenoma | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 112 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 1| 3| 1| 3| 3| 3| 0| 3| 3| 3| 0| 3| 0| 2| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| | | 4| 7| 3| 7| 7| 6| 9| 7| 6| 7| 5| 6| 7| 1| 7| 1| 6| 6| 7| 7| 9| 7| 7| 7| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 600 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 12 | Pars Distalis, Adenoma | X X X X X X X | 13 | Pars Distalis, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X | 6 | C-Cell, Carcinoma | X X | 2 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X | 4 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X| 42 | Interstitial Cell, Adenoma | X X | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 113 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 1| 3| 1| 3| 3| 3| 0| 3| 3| 3| 0| 3| 0| 2| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| | | 4| 7| 3| 7| 7| 6| 9| 7| 6| 7| 5| 6| 7| 1| 7| 1| 6| 6| 7| 7| 9| 7| 7| 7| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 600 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 7 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + +| 41 | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | X | 1 | Inguinal, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X X X X X X X X X| 19 | Mediastinal, Osteosarcoma, | | | Metastatic, Spleen | | 1 | Pancreatic, Leukemia Mononuclear | X X X | 4 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X | 16 | Osteosarcoma, Metastatic, Spleen | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X| 22 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + M + + + + + +| 47 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibroadenoma | X | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 114 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 1| 3| 1| 3| 3| 3| 0| 3| 3| 3| 0| 3| 0| 2| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| | | 4| 7| 3| 7| 7| 6| 9| 7| 6| 7| 5| 6| 7| 1| 7| 1| 6| 6| 7| 7| 9| 7| 7| 7| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 600 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | | 3 | Squamous Cell Papilloma | X | 3 | Subcutaneous Tissue, Fibroma | X | 2 | Subcutaneous Tissue, Fibrosarcoma | X X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Osteosarcoma, Metastatic, Spleen | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 1 | Carcinoma, Metastatic, Pituitary | | | Gland | X | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X| 22 | Squamous Cell Carcinoma | X | 1 | Mediastinum, Squamous Cell Carcinoma,| | | Metastatic, Lung | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 115 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| | DAY ON TEST | 1| 3| 1| 3| 3| 3| 0| 3| 3| 3| 0| 3| 0| 2| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| | | 4| 7| 3| 7| 7| 6| 9| 7| 6| 7| 5| 6| 7| 1| 7| 1| 6| 6| 7| 7| 9| 7| 7| 7| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 600 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + | 3 | |__________________________________________________________________________|____________| Zymbal's Gland | + | 2 | Adenoma | | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X| 22 | Renal Tubule, Carcinoma | | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 2 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 23 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 116 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 6| 7| 7| 7| 1| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 8| 3| 1| 3| 0| 3| 8| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 4| 6| 3| 6| 8| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Polyp Adenomatous | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Mesothelioma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Carcinoma, Metastatic, Intestine | | Small, Jejunum | X | Mesothelioma Malignant | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Mesothelioma Malignant | | |__________________________________________________________________________| Mesentery | + + + + + + + + | Mesothelioma Malignant | X | |__________________________________________________________________________| Oral Mucosa | | Squamous Cell Papilloma | | Gingival, Squamous Cell Carcinoma, | | Metastatic, Nose | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 117 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 6| 7| 7| 7| 1| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 8| 3| 1| 3| 0| 3| 8| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 4| 6| 3| 6| 8| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 118 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 6| 7| 7| 7| 1| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 8| 3| 1| 3| 0| 3| 8| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 4| 6| 3| 6| 8| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X X | |__________________________________________________________________________| Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | Leukemia Mononuclear | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| Page 119 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 6| 7| 7| 7| 1| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 8| 3| 1| 3| 0| 3| 8| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 4| 6| 3| 6| 8| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + | Mediastinal, Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Mesothelioma Malignant | | |__________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Keratoacanthoma | X X X | Keratoacanthoma, Multiple | X | Trichoepithelioma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 120 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 6| 7| 7| 7| 1| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 8| 3| 1| 3| 0| 3| 8| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 4| 6| 3| 6| 8| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Leukemia Mononuclear | X | Oligodendroglioma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | M | |__________________________________________________________________________| Harderian Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________|__________________________________________________________________________| Page 121 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 6| 7| 7| 7| 1| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 8| 3| 1| 3| 0| 3| 8| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 4| 6| 3| 6| 8| 6| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Adenoma | | Renal Tubule, Oncocytoma Benign | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Mesothelioma Malignant | X X X | __________________________________________|__________________________________________________________________________| Page 122 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 3| 6| 7| 5| 2| 1| 7| 7| 1| 6| 1| 1| 1| 1| 7| 7| 6| 7| 7| 4| 7| 7| 1| 6| 7| DAY ON TEST | 6| 7| 3| 9| 6| 8| 3| 3| 8| 9| 8| 8| 8| 8| 3| 3| 8| 3| 0| 6| 3| 0| 8| 7| 3| | 0| 5| 6| 2| 5| 4| 6| 6| 4| 8| 4| 4| 4| 4| 6| 6| 4| 6| 2| 0| 6| 2| 4| 7| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +| Leiomyoma | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M +| Mesothelioma Malignant | | Polyp Adenomatous | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Mesothelioma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + M +| Carcinoma | X | Carcinoma, Metastatic, Intestine | | Small, Jejunum | | Mesothelioma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Mesothelioma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + | Mesothelioma Malignant | X X | |__________________________________________________________________________| Oral Mucosa | + + | Squamous Cell Papilloma | X | Gingival, Squamous Cell Carcinoma, | | Metastatic, Nose | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 123 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 3| 6| 7| 5| 2| 1| 7| 7| 1| 6| 1| 1| 1| 1| 7| 7| 6| 7| 7| 4| 7| 7| 1| 6| 7| DAY ON TEST | 6| 7| 3| 9| 6| 8| 3| 3| 8| 9| 8| 8| 8| 8| 3| 3| 8| 3| 0| 6| 3| 0| 8| 7| 3| | 0| 5| 6| 2| 5| 4| 6| 6| 4| 8| 4| 4| 4| 4| 6| 6| 4| 6| 2| 0| 6| 2| 4| 7| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 124 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 3| 6| 7| 5| 2| 1| 7| 7| 1| 6| 1| 1| 1| 1| 7| 7| 6| 7| 7| 4| 7| 7| 1| 6| 7| DAY ON TEST | 6| 7| 3| 9| 6| 8| 3| 3| 8| 9| 8| 8| 8| 8| 3| 3| 8| 3| 0| 6| 3| 0| 8| 7| 3| | 0| 5| 6| 2| 5| 4| 6| 6| 4| 8| 4| 4| 4| 4| 6| 6| 4| 6| 2| 0| 6| 2| 4| 7| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Leukemia Mononuclear | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| Page 125 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 3| 6| 7| 5| 2| 1| 7| 7| 1| 6| 1| 1| 1| 1| 7| 7| 6| 7| 7| 4| 7| 7| 1| 6| 7| DAY ON TEST | 6| 7| 3| 9| 6| 8| 3| 3| 8| 9| 8| 8| 8| 8| 3| 3| 8| 3| 0| 6| 3| 0| 8| 7| 3| | 0| 5| 6| 2| 5| 4| 6| 6| 4| 8| 4| 4| 4| 4| 6| 6| 4| 6| 2| 0| 6| 2| 4| 7| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mesothelioma Malignant | X | |__________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Fibroadenoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X | Keratoacanthoma | X X | Keratoacanthoma, Multiple | | Trichoepithelioma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 126 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 3| 6| 7| 5| 2| 1| 7| 7| 1| 6| 1| 1| 1| 1| 7| 7| 6| 7| 7| 4| 7| 7| 1| 6| 7| DAY ON TEST | 6| 7| 3| 9| 6| 8| 3| 3| 8| 9| 8| 8| 8| 8| 3| 3| 8| 3| 0| 6| 3| 0| 8| 7| 3| | 0| 5| 6| 2| 5| 4| 6| 6| 4| 8| 4| 4| 4| 4| 6| 6| 4| 6| 2| 0| 6| 2| 4| 7| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | Leukemia Mononuclear | | Oligodendroglioma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | X | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X X X X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + | |__________________________________________________________________________| Harderian Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________|__________________________________________________________________________| Page 127 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 _____________________________________________________________________________________________________________________ | 3| 6| 7| 5| 2| 1| 7| 7| 1| 6| 1| 1| 1| 1| 7| 7| 6| 7| 7| 4| 7| 7| 1| 6| 7| DAY ON TEST | 6| 7| 3| 9| 6| 8| 3| 3| 8| 9| 8| 8| 8| 8| 3| 3| 8| 3| 0| 6| 3| 0| 8| 7| 3| | 0| 5| 6| 2| 5| 4| 6| 6| 4| 8| 4| 4| 4| 4| 6| 6| 4| 6| 2| 0| 6| 2| 4| 7| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Adenoma | | Renal Tubule, Oncocytoma Benign | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M +| Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Mesothelioma Malignant | X X X | __________________________________________|__________________________________________________________________________| Page 128 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 7| 5| 1| 7| 7| | | DAY ON TEST | 8| 2| 6| 0| 3| 3| 3| 8| 3| 3| | | | 0| 5| 1| 2| 6| 6| 6| 4| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 59 | Leiomyoma | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | Mesothelioma Malignant | | 1 | Polyp Adenomatous | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Carcinoma | | 1 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | Carcinoma | | 1 | Carcinoma, Metastatic, Intestine | | | Small, Jejunum | | 1 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 15 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 15 | Mesothelioma Malignant | X | 4 | |__________________________________________________________________________|____________| Oral Mucosa | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 129 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 7| 5| 1| 7| 7| | | DAY ON TEST | 8| 2| 6| 0| 3| 3| 3| 8| 3| 3| | | | 0| 5| 1| 2| 6| 6| 6| 4| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Squamous Cell Papilloma | | 1 | Gingival, Squamous Cell Carcinoma, | | | Metastatic, Nose | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Mesothelioma Malignant | X | 4 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Mesothelioma Malignant | | 2 | |__________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Adenoma | X | 1 | Leukemia Mononuclear | X | 5 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 5 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 130 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 7| 5| 1| 7| 7| | | DAY ON TEST | 8| 2| 6| 0| 3| 3| 3| 8| 3| 3| | | | 0| 5| 1| 2| 6| 6| 6| 4| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Malignant | X X | 3 | Pheochromocytoma Benign | X X | 12 | Bilateral, Pheochromocytoma Benign | | 4 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + | 56 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 5 | Pars Distalis, Adenoma | X X | 16 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | C-Cell, Adenoma | | 4 | Follicular Cell, Adenoma | | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | | 2 | Mesothelioma Malignant | | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Mesothelioma Malignant | X X X | 9 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 59 | Adenoma | | 4 | Carcinoma | X | 2 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 131 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 7| 5| 1| 7| 7| | | DAY ON TEST | 8| 2| 6| 0| 3| 3| 3| 8| 3| 3| | | | 0| 5| 1| 2| 6| 6| 6| 4| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Mesothelioma Malignant | | 2 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | Mesothelioma Malignant | X | 3 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Mesothelioma Malignant | X | 5 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X | 38 | Interstitial Cell, Adenoma | X | 7 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + | 28 | Mediastinal, Leukemia Mononuclear | X | 6 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 6 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Leukemia Mononuclear | X | 6 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 14 | Mesothelioma Malignant | X | 2 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 58 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 132 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 7| 5| 1| 7| 7| | | DAY ON TEST | 8| 2| 6| 0| 3| 3| 3| 8| 3| 3| | | | 0| 5| 1| 2| 6| 6| 6| 4| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 58 | Fibroadenoma | | 2 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basal Cell Adenoma | | 2 | Keratoacanthoma | X | 6 | Keratoacanthoma, Multiple | | 1 | Trichoepithelioma | X | 2 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Astrocytoma Malignant | X | 2 | Leukemia Mononuclear | | 1 | Oligodendroglioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 133 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 09/14/00 Route: DOSED FEED Time: 13:37:10 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 7| 5| 1| 7| 7| | | DAY ON TEST | 8| 2| 6| 0| 3| 3| 3| 8| 3| 3| | | | 0| 5| 1| 2| 6| 6| 6| 4| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Leukemia Mononuclear | X X X X | 15 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Squamous Cell Carcinoma | | 5 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 3 | |__________________________________________________________________________|____________| Harderian Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 14 | Renal Tubule, Adenoma | X X | 2 | Renal Tubule, Oncocytoma Benign | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 59 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Leukemia Mononuclear | X X X X | 15 | Mesothelioma Malignant | X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 134 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------