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TDMS Study 89002-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97

EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:13:34
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:13:34     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF           PENTACHLOROPHENOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Medulla                        Pheochromocytoma Benign
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS
Brain                                  Oligodendroglioma, Glioma, or Astrocytoma
Clitoral/Preputial Gland               Carcinoma
                                       Carcinoma or Adenoma
Intestine Small: Site Unspecified      Carcinoma
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
                                       Carcinoma or Adenoma
Skin                                   Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma

Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, malignant or NOS), or Trichoepithelioma

Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom
                                       Keratoacanthoma
                                       Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
                                       Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
                                       Trichoepithelioma
Testes                                 Adenoma
Thyroid Gland: C-Cell                  Adenoma
                                       Carcinoma or Adenoma
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                       Mesothelioma: Benign, Malignant, NOS
                                       Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Medulla                        Pheochromocytoma: Benign, Complex, Malignant, NOS
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland                          Fibroadenoma
                                       Fibroma, Fibroadenoma or Adenoma
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
                                       Carcinoma or Adenoma
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:13:34     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       

Thyroid Gland: C-Cell                  Adenoma
All Organs                             Benign Tumors
===============================================================
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)        -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        14/60 (23%)      21/50 (42%)      20/50 (40%)      23/50 (46%)      16/60 (27%)                      |
|POLY-3 ADJUSTED (b)|        34.9%            53.7%            50.0%            52.3%            37.7%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/12 (42%)       11/16 (69%)      13/21 (62%)      19/31 (61%)      10/27 (37%)                      |
|FIRST INCIDENCE    |        579              507              583              702              684                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.009N**       P=0.214          P=0.507          P=0.252N         P=0.142N                         |
|POLY 3             |        P=0.455N         P=0.062          P=0.117          P=0.076          P=0.486                          |
|POLY 1.5           |        P=0.524          P=0.064          P=0.109          P=0.048 *        P=0.447                          |
|POLY 6             |        P=0.327N         P=0.049 *        P=0.107          P=0.110          P=0.553                          |
|LOGISTIC REGRESSION|        P=0.211N         P=0.067          P=0.153          P=0.221          P=0.556N                         |
|COCH-ARM / FISHERS |        P=0.497          P=0.030 *        P=0.047 *        P=0.011 *        P=0.417                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        3/50 (6%)        1/50 (2%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             7.0%             2.3%             2.5%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        3/33 (9%)        0/34 (0%)        1/28 (4%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        ---              738 (T)          690              738 (T)          738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.593          P=0.151          P=0.511          P=0.500          P=0.500                          |
|POLY 3             |        P=0.516N         P=0.125          P=0.509          P=0.497          P=0.507                          |
|POLY 1.5           |        P=0.527N         P=0.116          P=0.500          P=0.494          P=0.502                          |
|POLY 6             |        P=0.511N         P=0.135          P=0.517          P=0.495          P=0.511                          |
|LOGISTIC REGRESSION|        P=0.581N         P=0.151          P=0.495          P=0.500          P=0.500                          |
|COCH-ARM / FISHERS |        P=0.561N         P=0.091          P=0.455          P=0.455          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        1/50 (2%)        3/50 (6%)        1/50 (2%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             2.8%             7.9%             2.3%             7.1%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        1/16 (6%)        3/21 (14%)       1/31 (3%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        736 (T)          736 (T)          736 (T)          736 (T)          680                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.486          P=0.698N         P=0.520          P=0.537N         P=0.563                          |
|POLY 3             |        P=0.274          P=0.753          P=0.310          P=0.726N         P=0.346                          |
|POLY 1.5           |        P=0.246          P=0.751          P=0.298          P=0.749N         P=0.324                          |
|POLY 6             |        P=0.323          P=0.753          P=0.318          P=0.697N         P=0.383                          |
|LOGISTIC REGRESSION|        P=0.384          P=0.698N         P=0.520          P=0.537N         P=0.424                          |
|COCH-ARM / FISHERS |        P=0.225          P=0.705          P=0.244          P=0.705          P=0.309                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.3%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        1/33 (3%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              738 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.464N         P=0.533          (e)              (e)              (e)                              |
|POLY 3             |        P=0.394N         P=0.507          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.402N         P=0.497          (e)              (e)              (e)                              |
|POLY 6             |        P=0.391N         P=0.517          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.533          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.451N         P=0.455          (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        16/60 (27%)      22/50 (44%)      21/50 (42%)      24/50 (48%)      18/60 (30%)                      |
|POLY-3 ADJUSTED (b)|        39.8%            55.1%            52.5%            54.5%            42.2%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/12 (50%)       11/16 (69%)      14/21 (67%)      20/31 (65%)      11/27 (41%)                      |
|FIRST INCIDENCE    |        579              450              583              702              680                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.007N**       P=0.294          P=0.522N         P=0.132N         P=0.106N                         |
|POLY 3             |        P=0.473N         P=0.112          P=0.168          P=0.120          P=0.501                          |
|POLY 1.5           |        P=0.506          P=0.107          P=0.158          P=0.078          P=0.455                          |
|POLY 6             |        P=0.338N         P=0.098          P=0.155          P=0.168          P=0.579                          |
|LOGISTIC REGRESSION|        P=0.228N         P=0.103          P=0.216          P=0.340          P=0.519N                         |
|COCH-ARM / FISHERS |        P=0.484          P=0.044 *        P=0.068          P=0.017 *        P=0.420                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        4/50 (8%)        1/50 (2%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             9.3%             2.3%             2.5%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        4/33 (12%)       0/34 (0%)        1/28 (4%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        ---              738 (T)          690              738 (T)          738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.490N         P=0.085          P=0.511          P=0.500          P=0.500                          |
|POLY 3             |        P=0.395N         P=0.065          P=0.509          P=0.497          P=0.507                          |
|POLY 1.5           |        P=0.409N         P=0.058          P=0.500          P=0.494          P=0.502                          |
|POLY 6             |        P=0.387N         P=0.072          P=0.517          P=0.495          P=0.511                          |
|LOGISTIC REGRESSION|        P=0.470N         P=0.085          P=0.495          P=0.500          P=0.500                          |
|COCH-ARM / FISHERS |        P=0.453N         P=0.040 *        P=0.455          P=0.455          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Astrocytoma Malignant                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.6%             2.3%             4.6%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              563              610              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.111          (e)              P=0.495          P=0.539          P=0.240                          |
|POLY 3             |        P=0.091          (e)              P=0.506          P=0.531          P=0.272                          |
|POLY 1.5           |        P=0.081          (e)              P=0.498          P=0.512          P=0.257                          |
|POLY 6             |        P=0.110          (e)              P=0.513          P=0.554          P=0.296                          |
|LOGISTIC REGRESSION|        P=0.121          (e)              P=0.422          P=0.443          P=0.234                          |
|COCH-ARM / FISHERS |        P=0.075          (e)              P=0.455          P=0.455          P=0.248                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Astrocytoma Malignant                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              544              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.671N         (e)              P=0.509          (e)              (e)                              |
|POLY 3             |        P=0.653N         (e)              P=0.511          (e)              (e)                              |
|POLY 1.5           |        P=0.653N         (e)              P=0.501          (e)              (e)                              |
|POLY 6             |        P=0.658N         (e)              P=0.519          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.645N         (e)              P=0.384          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.668N         (e)              P=0.455          (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.6%             2.3%             6.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              563              610              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.039 *        (e)              P=0.495          P=0.539          P=0.125                          |
|POLY 3             |        P=0.030 *        (e)              P=0.506          P=0.531          P=0.151                          |
|POLY 1.5           |        P=0.026 *        (e)              P=0.498          P=0.512          P=0.137                          |
|POLY 6             |        P=0.039 *        (e)              P=0.513          P=0.554          P=0.174                          |
|LOGISTIC REGRESSION|        P=0.045 *        (e)              P=0.422          P=0.443          P=0.112                          |
|COCH-ARM / FISHERS |        P=0.023 *        (e)              P=0.455          P=0.455          P=0.122                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              544              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.671N         (e)              P=0.509          (e)              (e)                              |
|POLY 3             |        P=0.653N         (e)              P=0.511          (e)              (e)                              |
|POLY 1.5           |        P=0.653N         (e)              P=0.501          (e)              (e)                              |
|POLY 6             |        P=0.658N         (e)              P=0.519          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.645N         (e)              P=0.384          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.668N         (e)              P=0.455          (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/60 (7%)        1/50 (2%)        3/50 (6%)        1/50 (2%)        4/59 (7%)                        |
|POLY-3 ADJUSTED (b)|        10.5%            2.7%             7.7%             2.3%             9.5%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        2/21 (10%)       0/31 (0%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        647              450              521              544              550                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.444N         P=0.177N         P=0.372N         P=0.085N         P=0.408N                         |
|POLY 3             |        P=0.531          P=0.187N         P=0.492N         P=0.139N         P=0.592N                         |
|POLY 1.5           |        P=0.500          P=0.191N         P=0.509N         P=0.163N         P=0.623N                         |
|POLY 6             |        P=0.547N         P=0.189N         P=0.483N         P=0.116N         P=0.541N                         |
|LOGISTIC REGRESSION|        P=0.488          P=0.211N         P=0.504N         P=0.184N         P=0.618N                         |
|COCH-ARM / FISHERS |        P=0.484          P=0.244N         P=0.601N         P=0.244N         P=0.632                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        4/60 (7%)        1/50 (2%)        1/48 (2%)        3/50 (6%)        5/59 (8%)                        |
|POLY-3 ADJUSTED (b)|        9.6%             2.3%             2.4%             7.1%             11.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        3/28 (11%)       0/33 (0%)        1/34 (3%)        1/28 (4%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        645              701              738 (T)          417              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.188          P=0.143N         P=0.136N         P=0.507N         P=0.510                          |
|POLY 3             |        P=0.190          P=0.169N         P=0.179N         P=0.495N         P=0.521                          |
|POLY 1.5           |        P=0.195          P=0.183N         P=0.192N         P=0.509N         P=0.503                          |
|POLY 6             |        P=0.184          P=0.156N         P=0.169N         P=0.497N         P=0.538                          |
|LOGISTIC REGRESSION|        P=0.215          P=0.166N         P=0.169N         P=0.562N         P=0.496                          |
|COCH-ARM / FISHERS |        P=0.221          P=0.244N         P=0.259N         P=0.601N         P=0.489                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        7/50 (14%)       1/50 (2%)        0/50 (0%)        2/59 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             18.8%            2.6%             0.0%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        3/16 (19%)       0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        396              544              360              ---              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.105N         P=0.054          P=0.758          P=0.504N         P=0.588                          |
|POLY 3             |        P=0.137N         P=0.025 *        P=0.758N         P=0.475N         P=0.527                          |
|POLY 1.5           |        P=0.159N         P=0.024 *        P=0.758          P=0.492N         P=0.509                          |
|POLY 6             |        P=0.114N         P=0.024 *        P=0.753N         P=0.455N         P=0.559                          |
|LOGISTIC REGRESSION|        P=0.231N         P=0.024 *        P=0.469          P=0.760N         P=0.490                          |
|COCH-ARM / FISHERS |        P=0.228N         P=0.016 *        P=0.705          P=0.545N         P=0.494                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        2/48 (4%)        0/50 (0%)        1/59 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             2.3%             4.8%             0.0%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        0/33 (0%)        1/34 (3%)        0/28 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        715              700              670              ---              600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.307N         P=0.434N         P=0.631N         P=0.243N         P=0.489N                         |
|POLY 3             |        P=0.301N         P=0.487N         P=0.692N         P=0.240N         P=0.493N                         |
|POLY 1.5           |        P=0.298N         P=0.504N         P=0.680          P=0.244N         P=0.502N                         |
|POLY 6             |        P=0.310N         P=0.470N         P=0.677N         P=0.243N         P=0.485N                         |
|LOGISTIC REGRESSION|        P=0.302N         P=0.480N         P=0.692N         P=0.245N         P=0.500N                         |
|COCH-ARM / FISHERS |        P=0.300N         P=0.569N         P=0.603          P=0.295N         P=0.506N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        8/50 (16%)       4/50 (8%)        1/50 (2%)        5/59 (8%)                        |
|POLY-3 ADJUSTED (b)|        12.8%            21.0%            10.1%            2.3%             11.7%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        3/16 (19%)       2/21 (10%)       0/31 (0%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        396              450              360              544              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.082N         P=0.346          P=0.389N         P=0.048N*        P=0.420N                         |
|POLY 3             |        P=0.150N         P=0.251          P=0.490N         P=0.076N         P=0.576N                         |
|POLY 1.5           |        P=0.180N         P=0.245          P=0.510N         P=0.093N         P=0.611N                         |
|POLY 6             |        P=0.117N         P=0.248          P=0.481N         P=0.061N         P=0.519N                         |
|LOGISTIC REGRESSION|        P=0.238N         P=0.217          P=0.624N         P=0.150N         P=0.626N                         |
|COCH-ARM / FISHERS |        P=0.237N         P=0.173          P=0.615N         P=0.151N         P=0.618                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/60 (10%)       2/50 (4%)        3/48 (6%)        3/50 (6%)        6/59 (10%)                       |
|POLY-3 ADJUSTED (b)|        14.4%            4.6%             7.2%             7.1%             13.8%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/28 (14%)       0/33 (0%)        2/34 (6%)        1/28 (4%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        645              700              670              417              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.370          P=0.095N         P=0.173N         P=0.255N         P=0.602N                         |
|POLY 3             |        P=0.380          P=0.121N         P=0.241N         P=0.236N         P=0.592N                         |
|POLY 1.5           |        P=0.384          P=0.137N         P=0.264N         P=0.249N         P=0.614N                         |
|POLY 6             |        P=0.371          P=0.108N         P=0.223N         P=0.238N         P=0.570N                         |
|LOGISTIC REGRESSION|        P=0.400          P=0.118N         P=0.230N         P=0.279N         P=0.617                          |
|COCH-ARM / FISHERS |        P=0.411          P=0.203N         P=0.368N         P=0.344N         P=0.607                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              614                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.046 *        (e)              (e)              (e)              P=0.339                          |
|POLY 3             |        P=0.038 *        (e)              (e)              (e)              P=0.264                          |
|POLY 1.5           |        P=0.036 *        (e)              (e)              (e)              P=0.250                          |
|POLY 6             |        P=0.041 *        (e)              (e)              (e)              P=0.288                          |
|LOGISTIC REGRESSION|        P=0.034 *        (e)              (e)              (e)              P=0.254                          |
|COCH-ARM / FISHERS |        P=0.036 *        (e)              (e)              (e)              P=0.248                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              625              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.673N         (e)              P=0.510          (e)              (e)                              |
|POLY 3             |        P=0.653N         (e)              P=0.510          (e)              (e)                              |
|POLY 1.5           |        P=0.653N         (e)              P=0.500          (e)              (e)                              |
|POLY 6             |        P=0.658N         (e)              P=0.518          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.664N         (e)              P=0.451          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.668N         (e)              P=0.455          (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        2/48 (4%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             4.8%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        2/30 (7%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.241          (e)              (e)              P=0.455          P=0.662                          |
|POLY 3             |        P=0.133          (e)              (e)              P=0.262          P=0.521                          |
|POLY 1.5           |        P=0.124          (e)              (e)              P=0.239          P=0.510                          |
|POLY 6             |        P=0.157          (e)              (e)              P=0.290          P=0.539                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.455          P=0.662                          |
|COCH-ARM / FISHERS |        P=0.139          (e)              (e)              P=0.195          P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/49 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.245N         P=0.467N         P=0.461N         P=0.500N         P=0.500N                         |
|POLY 3             |        P=0.259N         P=0.497N         P=0.492N         P=0.503N         P=0.493N                         |
|POLY 1.5           |        P=0.251N         P=0.507N         P=0.501N         P=0.506N         P=0.498N                         |
|POLY 6             |        P=0.270N         P=0.487N         P=0.485N         P=0.505N         P=0.489N                         |
|LOGISTIC REGRESSION|        P=0.245N         (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.247N         P=0.550N         P=0.545N         P=0.545N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             2.8%             0.0%             0.0%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        0/21 (0%)        0/31 (0%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        695              736 (T)          ---              ---              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.560          P=0.729N         P=0.484N         P=0.408N         P=0.722                          |
|POLY 3             |        P=0.404          P=0.753          P=0.498N         P=0.471N         P=0.536                          |
|POLY 1.5           |        P=0.392          P=0.750          P=0.504N         P=0.490N         P=0.517                          |
|POLY 6             |        P=0.422          P=0.751          P=0.493N         P=0.451N         P=0.566                          |
|LOGISTIC REGRESSION|        P=0.483          P=0.760          P=0.495N         P=0.474N         P=0.617                          |
|COCH-ARM / FISHERS |        P=0.377          P=0.705          P=0.545N         P=0.545N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             4.6%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        2/31 (7%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              736 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.559          (e)              (e)              P=0.463          (e)                              |
|POLY 3             |        P=0.389          (e)              (e)              P=0.273          (e)                              |
|POLY 1.5           |        P=0.373          (e)              (e)              P=0.249          (e)                              |
|POLY 6             |        P=0.436          (e)              (e)              P=0.301          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.463          (e)                              |
|COCH-ARM / FISHERS |        P=0.413          (e)              (e)              P=0.204          (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        1/50 (2%)        0/50 (0%)        2/50 (4%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.7%             2.8%             0.0%             4.6%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        0/21 (0%)        2/31 (7%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        695              736 (T)          ---              736 (T)          736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.485          P=0.729N         P=0.484N         P=0.713N         P=0.722                          |
|POLY 3             |        P=0.281          P=0.753          P=0.498N         P=0.550          P=0.536                          |
|POLY 1.5           |        P=0.266          P=0.750          P=0.504N         P=0.518          P=0.517                          |
|POLY 6             |        P=0.313          P=0.751          P=0.493N         P=0.586          P=0.566                          |
|LOGISTIC REGRESSION|        P=0.402          P=0.760          P=0.495N         P=0.638          P=0.617                          |
|COCH-ARM / FISHERS |        P=0.269          P=0.705          P=0.545N         P=0.431          P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        2/50 (4%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             5.5%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        2/16 (13%)       0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              736 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.156N         P=0.302          (e)              (e)              (e)                              |
|POLY 3             |        P=0.219N         P=0.227          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.231N         P=0.225          (e)              (e)              (e)                              |
|POLY 6             |        P=0.211N         P=0.225          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.302          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.284N         P=0.204          (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        645              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.082N         P=0.216N         P=0.216N         P=0.255N         P=0.232N                         |
|POLY 3             |        P=0.097N         P=0.231N         P=0.230N         P=0.241N         P=0.231N                         |
|POLY 1.5           |        P=0.092N         P=0.241N         P=0.239N         P=0.244N         P=0.235N                         |
|POLY 6             |        P=0.103N         P=0.222N         P=0.224N         P=0.245N         P=0.228N                         |
|LOGISTIC REGRESSION|        P=0.082N         P=0.240N         P=0.239N         P=0.246N         P=0.232N                         |
|COCH-ARM / FISHERS |        P=0.086N         P=0.295N         P=0.295N         P=0.295N         P=0.248N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        2/50 (4%)        1/50 (2%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             5.5%             2.6%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        2/16 (13%)       0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              736 (T)          688              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.165N         P=0.302          P=0.515          (e)              (e)                              |
|POLY 3             |        P=0.223N         P=0.227          P=0.504          (e)              (e)                              |
|POLY 1.5           |        P=0.242N         P=0.225          P=0.497          (e)              (e)                              |
|POLY 6             |        P=0.204N         P=0.225          P=0.511          (e)              (e)                              |
|LOGISTIC REGRESSION|        P=0.220N         P=0.302          P=0.502          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.295N         P=0.204          P=0.455          (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        7.2%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/28 (7%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        645              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.030N*        P=0.101N         P=0.099N         P=0.131N         P=0.118N                         |
|POLY 3             |        P=0.039N*        P=0.114N         P=0.113N         P=0.122N         P=0.114N                         |
|POLY 1.5           |        P=0.037N*        P=0.122N         P=0.120N         P=0.124N         P=0.117N                         |
|POLY 6             |        P=0.043N*        P=0.107N         P=0.108N         P=0.124N         P=0.111N                         |
|LOGISTIC REGRESSION|        P=0.029N*        P=0.115N         P=0.114N         P=0.124N         P=0.114N                         |
|COCH-ARM / FISHERS |        P=0.033N*        P=0.159N         P=0.159N         P=0.159N         P=0.122N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.8%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              736 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.341N         P=0.557          (e)              (e)              (e)                              |
|POLY 3             |        P=0.390N         P=0.492          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.399N         P=0.490          (e)              (e)              (e)                              |
|POLY 6             |        P=0.388N         P=0.491          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.557          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.451N         P=0.455          (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        3/50 (6%)        2/50 (4%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             6.9%             4.7%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        2/33 (6%)        2/34 (6%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          430              738 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.111N         P=0.347          P=0.568          P=0.500N         P=0.500N                         |
|POLY 3             |        P=0.088N         P=0.325          P=0.514          P=0.503N         P=0.493N                         |
|POLY 1.5           |        P=0.092N         P=0.305          P=0.499          P=0.506N         P=0.498N                         |
|POLY 6             |        P=0.088N         P=0.345          P=0.526          P=0.505N         P=0.489N                         |
|LOGISTIC REGRESSION|        P=0.107N         P=0.261          P=0.568          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.110N         P=0.244          P=0.431          P=0.545N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.8%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              736 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.341N         P=0.557          (e)              (e)              (e)                              |
|POLY 3             |        P=0.390N         P=0.492          (e)              (e)              (e)                              |
|POLY 1.5           |        P=0.399N         P=0.490          (e)              (e)              (e)                              |
|POLY 6             |        P=0.388N         P=0.491          (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              P=0.557          (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.451N         P=0.455          (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        3/50 (6%)        3/50 (6%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             6.9%             7.0%             2.5%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        2/33 (6%)        3/34 (9%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          430              738 (T)          738 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.180N         P=0.347          P=0.376          P=0.762          P=0.500N                         |
|POLY 3             |        P=0.152N         P=0.325          P=0.320          P=0.759          P=0.493N                         |
|POLY 1.5           |        P=0.156N         P=0.305          P=0.304          P=0.755          P=0.498N                         |
|POLY 6             |        P=0.151N         P=0.345          P=0.332          P=0.756          P=0.489N                         |
|LOGISTIC REGRESSION|        P=0.167N         P=0.261          P=0.376          P=0.762          (e)                              |
|COCH-ARM / FISHERS |        P=0.169N         P=0.244          P=0.244          P=0.705          P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        5/50 (10%)       4/50 (8%)        2/50 (4%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        13.0%            13.8%            10.4%            4.6%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        3/16 (19%)       3/21 (14%)       2/31 (7%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        619              698              698              736 (T)          715                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.009N**       P=0.544N         P=0.329N         P=0.052N         P=0.081N                         |
|POLY 3             |        P=0.056N         P=0.595          P=0.503N         P=0.169N         P=0.181N                         |
|POLY 1.5           |        P=0.069N         P=0.594          P=0.518N         P=0.200N         P=0.199N                         |
|POLY 6             |        P=0.041N*        P=0.582          P=0.500N         P=0.140N         P=0.156N                         |
|LOGISTIC REGRESSION|        P=0.030N*        P=0.608          P=0.475N         P=0.154N         P=0.165N                         |
|COCH-ARM / FISHERS |        P=0.087N         P=0.509          P=0.615N         P=0.301N         P=0.219N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/60 (42%)      20/50 (40%)      19/50 (38%)      12/50 (24%)      15/60 (25%)                      |
|POLY-3 ADJUSTED (b)|        56.5%            45.7%            41.9%            28.6%            34.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        16/28 (57%)      16/33 (49%)      14/34 (41%)      7/28 (25%)       11/28 (39%)                      |
|FIRST INCIDENCE    |        507              620              417              634              600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.023N*        P=0.087N         P=0.063N         P=0.013N*        P=0.036N*                        |
|POLY 3             |        P=0.010N*        P=0.207N         P=0.115N         P=0.006N**       P=0.027N*                        |
|POLY 1.5           |        P=0.010N*        P=0.254N         P=0.156N         P=0.007N**       P=0.030N*                        |
|POLY 6             |        P=0.012N*        P=0.178N         P=0.095N         P=0.007N**       P=0.025N*                        |
|LOGISTIC REGRESSION|        P=0.008N**       P=0.162N         P=0.146N         P=0.007N**       P=0.020N*                        |
|COCH-ARM / FISHERS |        P=0.010N*        P=0.507N         P=0.423N         P=0.039N*        P=0.040N*                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        5/50 (10%)       4/50 (8%)        2/50 (4%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        13.0%            13.8%            10.4%            4.6%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        3/16 (19%)       3/21 (14%)       2/31 (7%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        619              698              698              736 (T)          715                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.009N**       P=0.544N         P=0.329N         P=0.052N         P=0.081N                         |
|POLY 3             |        P=0.056N         P=0.595          P=0.503N         P=0.169N         P=0.181N                         |
|POLY 1.5           |        P=0.069N         P=0.594          P=0.518N         P=0.200N         P=0.199N                         |
|POLY 6             |        P=0.041N*        P=0.582          P=0.500N         P=0.140N         P=0.156N                         |
|LOGISTIC REGRESSION|        P=0.030N*        P=0.608          P=0.475N         P=0.154N         P=0.165N                         |
|COCH-ARM / FISHERS |        P=0.087N         P=0.509          P=0.615N         P=0.301N         P=0.219N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/60 (42%)      20/50 (40%)      19/50 (38%)      13/50 (26%)      15/60 (25%)                      |
|POLY-3 ADJUSTED (b)|        56.5%            45.7%            41.9%            31.0%            34.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        16/28 (57%)      16/33 (49%)      14/34 (41%)      8/28 (29%)       11/28 (39%)                      |
|FIRST INCIDENCE    |        507              620              417              634              600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.026N*        P=0.087N         P=0.063N         P=0.022N*        P=0.036N*                        |
|POLY 3             |        P=0.013N*        P=0.207N         P=0.115N         P=0.011N*        P=0.027N*                        |
|POLY 1.5           |        P=0.012N*        P=0.254N         P=0.156N         P=0.014N*        P=0.030N*                        |
|POLY 6             |        P=0.015N*        P=0.178N         P=0.095N         P=0.013N*        P=0.025N*                        |
|LOGISTIC REGRESSION|        P=0.010N*        P=0.162N         P=0.146N         P=0.012N*        P=0.020N*                        |
|COCH-ARM / FISHERS |        P=0.012N*        P=0.507N         P=0.423N         P=0.064N         P=0.040N*                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        5/50 (10%)       4/50 (8%)        2/50 (4%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        13.0%            13.8%            10.4%            4.6%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        3/16 (19%)       3/21 (14%)       2/31 (7%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        619              698              698              736 (T)          715                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.009N**       P=0.544N         P=0.329N         P=0.052N         P=0.081N                         |
|POLY 3             |        P=0.056N         P=0.595          P=0.503N         P=0.169N         P=0.181N                         |
|POLY 1.5           |        P=0.069N         P=0.594          P=0.518N         P=0.200N         P=0.199N                         |
|POLY 6             |        P=0.041N*        P=0.582          P=0.500N         P=0.140N         P=0.156N                         |
|LOGISTIC REGRESSION|        P=0.030N*        P=0.608          P=0.475N         P=0.154N         P=0.165N                         |
|COCH-ARM / FISHERS |        P=0.087N         P=0.509          P=0.615N         P=0.301N         P=0.219N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/60 (42%)      22/50 (44%)      21/50 (42%)      13/50 (26%)      15/60 (25%)                      |
|POLY-3 ADJUSTED (b)|        56.5%            49.4%            46.3%            31.0%            34.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        16/28 (57%)      17/33 (52%)      16/34 (47%)      8/28 (29%)       11/28 (39%)                      |
|FIRST INCIDENCE    |        507              430              417              634              600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.017N*        P=0.164N         P=0.115N         P=0.022N*        P=0.036N*                        |
|POLY 3             |        P=0.008N**       P=0.320N         P=0.220N         P=0.011N*        P=0.027N*                        |
|POLY 1.5           |        P=0.007N**       P=0.387N         P=0.279N         P=0.014N*        P=0.030N*                        |
|POLY 6             |        P=0.009N**       P=0.277N         P=0.191N         P=0.013N*        P=0.025N*                        |
|LOGISTIC REGRESSION|        P=0.006N**       P=0.314N         P=0.252N         P=0.012N*        P=0.020N*                        |
|COCH-ARM / FISHERS |        P=0.007N**       P=0.479          P=0.563          P=0.064N         P=0.040N*                        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        3/50 (6%)        1/50 (2%)        0/50 (0%)        5/60 (8%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             8.1%             2.6%             0.0%             11.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        643              505              593              ---              460                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.177          P=0.301          P=0.744          P=0.473N         P=0.210                          |
|POLY 3             |        P=0.150          P=0.297          P=0.757N         P=0.472N         P=0.133                          |
|POLY 1.5           |        P=0.135          P=0.291          P=0.758          P=0.490N         P=0.117                          |
|POLY 6             |        P=0.171          P=0.299          P=0.751N         P=0.452N         P=0.162                          |
|LOGISTIC REGRESSION|        P=0.111          P=0.253          P=0.730          P=0.527N         P=0.112                          |
|COCH-ARM / FISHERS |        P=0.111          P=0.244          P=0.705          P=0.545N         P=0.103                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 22
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             2.6%             0.0%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        702              ---              640              ---              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.513N         P=0.204N         P=0.423N         P=0.094N         P=0.419N                         |
|POLY 3             |        P=0.527          P=0.245N         P=0.492N         P=0.208N         P=0.657N                         |
|POLY 1.5           |        P=0.511          P=0.248N         P=0.505N         P=0.226N         P=0.676N                         |
|POLY 6             |        P=0.552          P=0.246N         P=0.482N         P=0.188N         P=0.624N                         |
|LOGISTIC REGRESSION|        P=0.584          P=0.237N         P=0.492N         P=0.159N         P=0.541N                         |
|COCH-ARM / FISHERS |        P=0.511          P=0.295N         P=0.569N         P=0.295N         P=0.691N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             0.0%             0.0%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/28 (7%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          ---              ---              ---              724                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.439N         P=0.202N         P=0.196N         P=0.238N         P=0.500N                         |
|POLY 3             |        P=0.440N         P=0.229N         P=0.228N         P=0.239N         P=0.488N                         |
|POLY 1.5           |        P=0.428N         P=0.240N         P=0.238N         P=0.243N         P=0.496N                         |
|POLY 6             |        P=0.457N         P=0.219N         P=0.221N         P=0.242N         P=0.480N                         |
|LOGISTIC REGRESSION|        P=0.426N         (e)              (e)              (e)              P=0.482N                         |
|COCH-ARM / FISHERS |        P=0.414N         P=0.295N         P=0.295N         P=0.295N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 23
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             2.6%             2.3%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        702              ---              640              605              736 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.578N         P=0.204N         P=0.423N         P=0.305N         P=0.419N                         |
|POLY 3             |        P=0.450          P=0.245N         P=0.492N         P=0.446N         P=0.657N                         |
|POLY 1.5           |        P=0.431          P=0.248N         P=0.505N         P=0.480N         P=0.676N                         |
|POLY 6             |        P=0.484          P=0.246N         P=0.482N         P=0.408N         P=0.624N                         |
|LOGISTIC REGRESSION|        P=0.477          P=0.237N         P=0.492N         P=0.482N         P=0.541N                         |
|COCH-ARM / FISHERS |        P=0.439          P=0.295N         P=0.569N         P=0.569N         P=0.691N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             0.0%             0.0%             0.0%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/28 (7%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          ---              ---              ---              701                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.461          P=0.202N         P=0.196N         P=0.238N         P=0.679N                         |
|POLY 3             |        P=0.449          P=0.229N         P=0.228N         P=0.239N         P=0.681N                         |
|POLY 1.5           |        P=0.460          P=0.240N         P=0.238N         P=0.243N         P=0.689N                         |
|POLY 6             |        P=0.437          P=0.219N         P=0.221N         P=0.242N         P=0.671N                         |
|LOGISTIC REGRESSION|        P=0.477          (e)              (e)              (e)              P=0.675N                         |
|COCH-ARM / FISHERS |        P=0.488          P=0.295N         P=0.295N         P=0.295N         P=0.691N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 24
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        1/50 (2%)        0/48 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             2.6%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        0/16 (0%)        1/21 (5%)        0/30 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        660              ---              736 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.052N         P=0.219N         P=0.380N         P=0.123N         P=0.132N                         |
|POLY 3             |        P=0.110N         P=0.246N         P=0.497N         P=0.217N         P=0.215N                         |
|POLY 1.5           |        P=0.116N         P=0.248N         P=0.508N         P=0.236N         P=0.226N                         |
|POLY 6             |        P=0.103N         P=0.248N         P=0.490N         P=0.198N         P=0.198N                         |
|LOGISTIC REGRESSION|        P=0.084N         P=0.246N         P=0.477N         P=0.207N         P=0.204N                         |
|COCH-ARM / FISHERS |        P=0.119N         P=0.295N         P=0.569N         P=0.306N         P=0.248N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/49 (0%)        0/50 (0%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.134          (e)              (e)              (e)              P=0.500                          |
|POLY 3             |        P=0.152          (e)              (e)              (e)              P=0.507                          |
|POLY 1.5           |        P=0.153          (e)              (e)              (e)              P=0.502                          |
|POLY 6             |        P=0.152          (e)              (e)              (e)              P=0.511                          |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.500                          |
|COCH-ARM / FISHERS |        P=0.161          (e)              (e)              (e)              P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 25
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        18/60 (30%)      16/50 (32%)      14/49 (29%)      13/50 (26%)      16/60 (27%)                      |
|POLY-3 ADJUSTED (b)|        41.3%            40.1%            34.4%            29.5%            36.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/12 (33%)       6/16 (38%)       5/21 (24%)       11/31 (36%)      7/27 (26%)                       |
|FIRST INCIDENCE    |        396              524              443              620              565                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.020N*        P=0.372N         P=0.142N         P=0.006N**       P=0.082N                         |
|POLY 3             |        P=0.252N         P=0.545N         P=0.331N         P=0.171N         P=0.400N                         |
|POLY 1.5           |        P=0.288N         P=0.530N         P=0.343N         P=0.208N         P=0.420N                         |
|POLY 6             |        P=0.193N         P=0.588N         P=0.342N         P=0.144N         P=0.348N                         |
|LOGISTIC REGRESSION|        P=0.229N         P=0.553N         P=0.390N         P=0.201N         P=0.348N                         |
|COCH-ARM / FISHERS |        P=0.295N         P=0.492          P=0.520N         P=0.402N         P=0.420N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        22/60 (37%)      20/50 (40%)      14/50 (28%)      16/50 (32%)      18/60 (30%)                      |
|POLY-3 ADJUSTED (b)|        48.9%            44.9%            31.5%            38.1%            41.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        11/28 (39%)      15/33 (46%)      10/34 (29%)      11/28 (39%)      13/28 (46%)                      |
|FIRST INCIDENCE    |        507              522              544              592              652                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.279N         P=0.247N         P=0.039N*        P=0.197N         P=0.262N                         |
|POLY 3             |        P=0.240N         P=0.431N         P=0.068N         P=0.205N         P=0.305N                         |
|POLY 1.5           |        P=0.218N         P=0.479N         P=0.082N         P=0.203N         P=0.298N                         |
|POLY 6             |        P=0.281N         P=0.409N         P=0.065N         P=0.255N         P=0.330N                         |
|LOGISTIC REGRESSION|        P=0.182N         P=0.434N         P=0.073N         P=0.170N         P=0.223N                         |
|COCH-ARM / FISHERS |        P=0.174N         P=0.435          P=0.224N         P=0.379N         P=0.281N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 26
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        18/60 (30%)      16/50 (32%)      14/49 (29%)      14/50 (28%)      16/60 (27%)                      |
|POLY-3 ADJUSTED (b)|        41.3%            40.1%            34.4%            31.8%            36.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        4/12 (33%)       6/16 (38%)       5/21 (24%)       12/31 (39%)      7/27 (26%)                       |
|FIRST INCIDENCE    |        396              524              443              620              565                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.022N*        P=0.372N         P=0.142N         P=0.008N**       P=0.082N                         |
|POLY 3             |        P=0.277N         P=0.545N         P=0.331N         P=0.236N         P=0.400N                         |
|POLY 1.5           |        P=0.314N         P=0.530N         P=0.343N         P=0.280N         P=0.420N                         |
|POLY 6             |        P=0.214N         P=0.588N         P=0.342N         P=0.204N         P=0.348N                         |
|LOGISTIC REGRESSION|        P=0.246N         P=0.553N         P=0.390N         P=0.261N         P=0.348N                         |
|COCH-ARM / FISHERS |        P=0.316N         P=0.492          P=0.520N         P=0.493N         P=0.420N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        22/60 (37%)      20/50 (40%)      14/50 (28%)      16/50 (32%)      18/60 (30%)                      |
|POLY-3 ADJUSTED (b)|        48.9%            44.9%            31.5%            38.1%            41.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        11/28 (39%)      15/33 (46%)      10/34 (29%)      11/28 (39%)      13/28 (46%)                      |
|FIRST INCIDENCE    |        507              522              544              592              652                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.279N         P=0.247N         P=0.039N*        P=0.197N         P=0.262N                         |
|POLY 3             |        P=0.240N         P=0.431N         P=0.068N         P=0.205N         P=0.305N                         |
|POLY 1.5           |        P=0.218N         P=0.479N         P=0.082N         P=0.203N         P=0.298N                         |
|POLY 6             |        P=0.281N         P=0.409N         P=0.065N         P=0.255N         P=0.330N                         |
|LOGISTIC REGRESSION|        P=0.182N         P=0.434N         P=0.073N         P=0.170N         P=0.223N                         |
|COCH-ARM / FISHERS |        P=0.174N         P=0.435          P=0.224N         P=0.379N         P=0.281N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 27
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             0.0%             0.0%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        684              ---              ---              ---              592                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.292          P=0.515N         P=0.500N         P=0.427N         P=0.628                          |
|POLY 3             |        P=0.228          P=0.509N         P=0.498N         P=0.472N         P=0.539                          |
|POLY 1.5           |        P=0.222          P=0.510N         P=0.504N         P=0.490N         P=0.519                          |
|POLY 6             |        P=0.240          P=0.511N         P=0.494N         P=0.451N         P=0.572                          |
|LOGISTIC REGRESSION|        P=0.228          P=0.510N         P=0.499N         P=0.487N         P=0.526                          |
|COCH-ARM / FISHERS |        P=0.225          P=0.545N         P=0.545N         P=0.545N         P=0.500                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 28
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             0.0%             0.0%             9.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        684              ---              ---              ---              592                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.042 *        P=0.515N         P=0.500N         P=0.427N         P=0.312                          |
|POLY 3             |        P=0.024 *        P=0.509N         P=0.498N         P=0.472N         P=0.217                          |
|POLY 1.5           |        P=0.023 *        P=0.510N         P=0.504N         P=0.490N         P=0.197                          |
|POLY 6             |        P=0.027 *        P=0.511N         P=0.494N         P=0.451N         P=0.253                          |
|LOGISTIC REGRESSION|        P=0.023 *        P=0.510N         P=0.499N         P=0.487N         P=0.204                          |
|COCH-ARM / FISHERS |        P=0.023 *        P=0.545N         P=0.545N         P=0.545N         P=0.182                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 29
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             2.6%             0.0%             9.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        1/21 (5%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        684              ---              736 (T)          ---              592                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.076          P=0.515N         P=0.700N         P=0.427N         P=0.312                          |
|POLY 3             |        P=0.044 *        P=0.509N         P=0.759N         P=0.472N         P=0.217                          |
|POLY 1.5           |        P=0.040 *        P=0.510N         P=0.757          P=0.490N         P=0.197                          |
|POLY 6             |        P=0.051          P=0.511N         P=0.755N         P=0.451N         P=0.253                          |
|LOGISTIC REGRESSION|        P=0.040 *        P=0.510N         P=0.750N         P=0.487N         P=0.204                          |
|COCH-ARM / FISHERS |        P=0.039 *        P=0.545N         P=0.705          P=0.545N         P=0.182                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 30
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        3/50 (6%)        2/50 (4%)        5/50 (10%)       9/60 (15%)                       |
|POLY-3 ADJUSTED (b)|        7.9%             8.3%             5.2%             11.3%            21.0%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       1/16 (6%)        2/21 (10%)       4/31 (13%)       4/27 (15%)                       |
|FIRST INCIDENCE    |        684              722              736 (T)          518              592                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.111          P=0.574N         P=0.301N         P=0.522N         P=0.297                          |
|POLY 3             |        P=0.023 *        P=0.646          P=0.495N         P=0.446          P=0.090                          |
|POLY 1.5           |        P=0.018 *        P=0.640          P=0.509N         P=0.389          P=0.073                          |
|POLY 6             |        P=0.036 *        P=0.644          P=0.486N         P=0.511          P=0.125                          |
|LOGISTIC REGRESSION|        P=0.030 *        P=0.665N         P=0.428N         P=0.453          P=0.106                          |
|COCH-ARM / FISHERS |        P=0.017 *        P=0.570          P=0.586N         P=0.262          P=0.063                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             2.5%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        1/34 (3%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              738 (T)          738 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.551          (e)              P=0.539          P=0.500          (e)                              |
|POLY 3             |        P=0.537          (e)              P=0.508          P=0.497          (e)                              |
|POLY 1.5           |        P=0.535          (e)              P=0.499          P=0.494          (e)                              |
|POLY 6             |        P=0.541          (e)              P=0.515          P=0.495          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.539          P=0.500          (e)                              |
|COCH-ARM / FISHERS |        P=0.570          (e)              P=0.455          P=0.455          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 31
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        2/50 (4%)        2/50 (4%)        2/50 (4%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        5.2%             5.4%             5.2%             4.5%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        1/21 (5%)        1/31 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        603              505              666              614              614                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.217N         P=0.680N         P=0.649N         P=0.551N         P=0.447N                         |
|POLY 3             |        P=0.306N         P=0.681          P=0.694N         P=0.642N         P=0.466N                         |
|POLY 1.5           |        P=0.332N         P=0.677          P=0.686          P=0.676N         P=0.483N                         |
|POLY 6             |        P=0.267N         P=0.679          P=0.689N         P=0.604N         P=0.438N                         |
|LOGISTIC REGRESSION|        P=0.343N         P=0.646          P=0.684          P=0.673          P=0.492N                         |
|COCH-ARM / FISHERS |        P=0.353N         P=0.619          P=0.619          P=0.619          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             2.3%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        1/33 (3%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        523              738 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.061N         P=0.465N         P=0.216N         P=0.237N         P=0.240N                         |
|POLY 3             |        P=0.065N         P=0.493N         P=0.231N         P=0.243N         P=0.233N                         |
|POLY 1.5           |        P=0.064N         P=0.508N         P=0.240N         P=0.245N         P=0.236N                         |
|POLY 6             |        P=0.068N         P=0.479N         P=0.226N         P=0.247N         P=0.229N                         |
|LOGISTIC REGRESSION|        P=0.063N         P=0.535N         P=0.277N         P=0.275N         P=0.237N                         |
|COCH-ARM / FISHERS |        P=0.065N         P=0.569N         P=0.295N         P=0.295N         P=0.248N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 32
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        3/50 (6%)        2/50 (4%)        4/50 (8%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        13.0%            8.0%             5.2%             9.1%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       1/16 (6%)        1/21 (5%)        3/31 (10%)       0/27 (0%)                        |
|FIRST INCIDENCE    |        603              505              666              614              614                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.071N         P=0.315N         P=0.136N         P=0.159N         P=0.098N                         |
|POLY 3             |        P=0.184N         P=0.368N         P=0.213N         P=0.416N         P=0.176N                         |
|POLY 1.5           |        P=0.206N         P=0.378N         P=0.225N         P=0.471N         P=0.196N                         |
|POLY 6             |        P=0.149N         P=0.369N         P=0.206N         P=0.358N         P=0.147N                         |
|LOGISTIC REGRESSION|        P=0.188N         P=0.408N         P=0.208N         P=0.420N         P=0.185N                         |
|COCH-ARM / FISHERS |        P=0.212N         P=0.464N         P=0.301N         P=0.615N         P=0.219N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        1/50 (2%)        1/50 (2%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        7.2%             2.3%             2.3%             2.4%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/28 (7%)        1/33 (3%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        523              738 (T)          733              646              516                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.234N         P=0.265N         P=0.254N         P=0.316N         P=0.306N                         |
|POLY 3             |        P=0.240N         P=0.297N         P=0.296N         P=0.312N         P=0.293N                         |
|POLY 1.5           |        P=0.236N         P=0.313N         P=0.309N         P=0.317N         P=0.301N                         |
|POLY 6             |        P=0.247N         P=0.284N         P=0.286N         P=0.315N         P=0.285N                         |
|LOGISTIC REGRESSION|        P=0.224N         P=0.319N         P=0.318N         P=0.342N         P=0.304N                         |
|COCH-ARM / FISHERS |        P=0.224N         P=0.381N         P=0.381N         P=0.381N         P=0.309N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 33
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        0/50 (0%)        0/50 (0%)        2/50 (4%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             0.0%             0.0%             4.6%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       0/16 (0%)        0/21 (0%)        2/31 (7%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        736 (T)          ---              ---              736 (T)          680                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.379N         P=0.175N         P=0.124N         P=0.329N         P=0.288N                         |
|POLY 3             |        P=0.594N         P=0.245N         P=0.233N         P=0.639N         P=0.461N                         |
|POLY 1.5           |        P=0.580          P=0.248N         P=0.241N         P=0.675N         P=0.481N                         |
|POLY 6             |        P=0.569N         P=0.245N         P=0.227N         P=0.595N         P=0.428N                         |
|LOGISTIC REGRESSION|        P=0.470N         (e)              (e)              P=0.329N         P=0.405N                         |
|COCH-ARM / FISHERS |        P=0.589N         P=0.295N         P=0.295N         P=0.619          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             2.3%             2.4%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          ---              733              646              516                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.469          P=0.467N         P=0.713N         P=0.748          P=0.758N                         |
|POLY 3             |        P=0.455          P=0.493N         P=0.751N         P=0.760          P=0.750N                         |
|POLY 1.5           |        P=0.457          P=0.503N         P=0.760          P=0.755          P=0.756N                         |
|POLY 6             |        P=0.453          P=0.483N         P=0.743N         P=0.760          P=0.744N                         |
|LOGISTIC REGRESSION|        P=0.485          (e)              P=0.731N         P=0.754          P=0.762N                         |
|COCH-ARM / FISHERS |        P=0.488          P=0.545N         P=0.705          P=0.705          P=0.752N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 34
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        1/50 (2%)        0/50 (0%)        2/50 (4%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        8.0%             2.7%             0.0%             4.6%             2.4%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       0/16 (0%)        0/21 (0%)        2/31 (7%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        695              507              ---              736 (T)          680                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.137N         P=0.259N         P=0.061N         P=0.158N         P=0.135N                         |
|POLY 3             |        P=0.286N         P=0.312N         P=0.115N         P=0.435N         P=0.267N                         |
|POLY 1.5           |        P=0.299N         P=0.319N         P=0.122N         P=0.477N         P=0.286N                         |
|POLY 6             |        P=0.264N         P=0.310N         P=0.111N         P=0.388N         P=0.236N                         |
|LOGISTIC REGRESSION|        P=0.252N         P=0.327N         P=0.095N         P=0.279N         P=0.227N                         |
|COCH-ARM / FISHERS |        P=0.292N         P=0.381N         P=0.159N         P=0.586N         P=0.309N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             0.0%             2.3%             2.4%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          ---              733              646              516                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.469          P=0.467N         P=0.713N         P=0.748          P=0.758N                         |
|POLY 3             |        P=0.455          P=0.493N         P=0.751N         P=0.760          P=0.750N                         |
|POLY 1.5           |        P=0.457          P=0.503N         P=0.760          P=0.755          P=0.756N                         |
|POLY 6             |        P=0.453          P=0.483N         P=0.743N         P=0.760          P=0.744N                         |
|LOGISTIC REGRESSION|        P=0.485          (e)              P=0.731N         P=0.754          P=0.762N                         |
|COCH-ARM / FISHERS |        P=0.488          P=0.545N         P=0.705          P=0.705          P=0.752N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 35
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        2/50 (4%)        1/50 (2%)        3/50 (6%)        7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        0.0%             5.5%             2.6%             6.8%             16.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        1/21 (5%)        2/31 (7%)        4/27 (15%)                       |
|FIRST INCIDENCE    |        ---              722              736 (T)          518              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.012 *        P=0.290          P=0.612          P=0.249          P=0.061                          |
|POLY 3             |        P=0.003 **       P=0.227          P=0.503          P=0.152          P=0.011 *                        |
|POLY 1.5           |        P=0.002 **       P=0.225          P=0.496          P=0.131          P=0.009 **                       |
|POLY 6             |        P=0.004 **       P=0.226          P=0.508          P=0.180          P=0.016 *                        |
|LOGISTIC REGRESSION|        P=0.003 **       P=0.246          P=0.612          P=0.103          P=0.025 *                        |
|COCH-ARM / FISHERS |        P=0.002 **       P=0.204          P=0.455          P=0.091          P=0.006 **                       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             2.5%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              738 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.536          (e)              (e)              P=0.500          (e)                              |
|POLY 3             |        P=0.502          (e)              (e)              P=0.497          (e)                              |
|POLY 1.5           |        P=0.501          (e)              (e)              P=0.494          (e)                              |
|POLY 6             |        P=0.510          (e)              (e)              P=0.495          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.500          (e)                              |
|COCH-ARM / FISHERS |        P=0.549          (e)              (e)              P=0.455          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 36
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        0/50 (0%)        3/50 (6%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        5.3%             2.8%             0.0%             6.9%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       0/16 (0%)        0/21 (0%)        3/31 (10%)       0/27 (0%)                        |
|FIRST INCIDENCE    |        736 (T)          723              ---              736 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.108N         P=0.413N         P=0.124N         P=0.456N         P=0.085N                         |
|POLY 3             |        P=0.291N         P=0.513N         P=0.233N         P=0.567          P=0.214N                         |
|POLY 1.5           |        P=0.307N         P=0.517N         P=0.241N         P=0.524          P=0.226N                         |
|POLY 6             |        P=0.260N         P=0.514N         P=0.227N         P=0.615          P=0.195N                         |
|LOGISTIC REGRESSION|        P=0.139N         P=0.468N         (e)              P=0.456N         (e)                              |
|COCH-ARM / FISHERS |        P=0.295N         P=0.569N         P=0.295N         P=0.414          P=0.248N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        1/34 (3%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              738 (T)          ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.694N         (e)              P=0.539          (e)              (e)                              |
|POLY 3             |        P=0.653N         (e)              P=0.508          (e)              (e)                              |
|POLY 1.5           |        P=0.653N         (e)              P=0.499          (e)              (e)                              |
|POLY 6             |        P=0.659N         (e)              P=0.515          (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.539          (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.668N         (e)              P=0.455          (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 37
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        3/50 (6%)        1/50 (2%)        5/50 (10%)       7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        5.3%             8.3%             2.6%             11.3%            16.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       1/16 (6%)        1/21 (5%)        4/31 (13%)       4/27 (15%)                       |
|FIRST INCIDENCE    |        736 (T)          722              736 (T)          518              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.149          P=0.608          P=0.306N         P=0.617          P=0.353                          |
|POLY 3             |        P=0.036 *        P=0.483          P=0.494N         P=0.288          P=0.106                          |
|POLY 1.5           |        P=0.029 *        P=0.478          P=0.506N         P=0.242          P=0.092                          |
|POLY 6             |        P=0.051          P=0.483          P=0.485N         P=0.346          P=0.137                          |
|LOGISTIC REGRESSION|        P=0.060          P=0.535          P=0.306N         P=0.295          P=0.208                          |
|COCH-ARM / FISHERS |        P=0.028 *        P=0.414          P=0.569N         P=0.151          P=0.081                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             2.5%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        1/34 (3%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              738 (T)          738 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.551          (e)              P=0.539          P=0.500          (e)                              |
|POLY 3             |        P=0.537          (e)              P=0.508          P=0.497          (e)                              |
|POLY 1.5           |        P=0.535          (e)              P=0.499          P=0.494          (e)                              |
|POLY 6             |        P=0.541          (e)              P=0.515          P=0.495          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.539          P=0.500          (e)                              |
|COCH-ARM / FISHERS |        P=0.570          (e)              P=0.455          P=0.455          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 38
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        3/50 (6%)        1/50 (2%)        5/50 (10%)       7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        5.3%             8.3%             2.6%             11.3%            16.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/12 (17%)       1/16 (6%)        1/21 (5%)        4/31 (13%)       4/27 (15%)                       |
|FIRST INCIDENCE    |        736 (T)          722              736 (T)          518              708                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.149          P=0.608          P=0.306N         P=0.617          P=0.353                          |
|POLY 3             |        P=0.036 *        P=0.483          P=0.494N         P=0.288          P=0.106                          |
|POLY 1.5           |        P=0.029 *        P=0.478          P=0.506N         P=0.242          P=0.092                          |
|POLY 6             |        P=0.051          P=0.483          P=0.485N         P=0.346          P=0.137                          |
|LOGISTIC REGRESSION|        P=0.060          P=0.535          P=0.306N         P=0.295          P=0.208                          |
|COCH-ARM / FISHERS |        P=0.028 *        P=0.414          P=0.569N         P=0.151          P=0.081                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        1/50 (2%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.3%             2.5%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        1/34 (3%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              738 (T)          738 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.551          (e)              P=0.539          P=0.500          (e)                              |
|POLY 3             |        P=0.537          (e)              P=0.508          P=0.497          (e)                              |
|POLY 1.5           |        P=0.535          (e)              P=0.499          P=0.494          (e)                              |
|POLY 6             |        P=0.541          (e)              P=0.515          P=0.495          (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              P=0.539          P=0.500          (e)                              |
|COCH-ARM / FISHERS |        P=0.570          (e)              P=0.455          P=0.455          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 39
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             4.7%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              661                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.050          (e)              (e)              (e)              P=0.328                          |
|POLY 3             |        P=0.038 *        (e)              (e)              (e)              P=0.264                          |
|POLY 1.5           |        P=0.036 *        (e)              (e)              (e)              P=0.250                          |
|POLY 6             |        P=0.041 *        (e)              (e)              (e)              P=0.288                          |
|LOGISTIC REGRESSION|        P=0.034 *        (e)              (e)              (e)              P=0.258                          |
|COCH-ARM / FISHERS |        P=0.036 *        (e)              (e)              (e)              P=0.248                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 40
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        42/60 (70%)      47/50 (94%)      45/50 (90%)      46/50 (92%)      45/60 (75%)                      |
|POLY-3 ADJUSTED (b)|        93.4%            97.5%            95.8%            95.6%            96.0%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        12/12 (100%)     16/16 (100%)     21/21 (100%)     31/31 (100%)     27/27 (100%)                     |
|FIRST INCIDENCE    |        561              410              521              518              502                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.465          P=0.181N         P<0.001N**       P=0.004N**                       |
|POLY 3             |        P=0.470          P=0.256          P=0.475          P=0.498          P=0.452                          |
|POLY 1.5           |        P=0.401          P=0.069          P=0.200          P=0.157          P=0.325                          |
|POLY 6             |        P=0.571N         P=0.587          P=0.782          P=0.782N         P=0.754                          |
|LOGISTIC REGRESSION|        P=0.511N         P=0.028 *        P=0.241          P=0.621          P=0.410                          |
|COCH-ARM / FISHERS |        P=0.536          P<0.001 **       P=0.009 **       P=0.003 **       P=0.342                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 41
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        8/50 (16%)       7/50 (14%)       6/50 (12%)       4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        12.8%            21.5%            17.7%            13.6%            9.5%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        5/16 (31%)       3/21 (14%)       5/31 (16%)       3/27 (11%)                       |
|FIRST INCIDENCE    |        535              450              593              544              675                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.043N*        P=0.354          P=0.528          P=0.348N         P=0.235N                         |
|POLY 3             |        P=0.192N         P=0.240          P=0.387          P=0.588          P=0.452N                         |
|POLY 1.5           |        P=0.231N         P=0.240          P=0.365          P=0.530          P=0.477N                         |
|POLY 6             |        P=0.141N         P=0.226          P=0.403          P=0.605N         P=0.410N                         |
|LOGISTIC REGRESSION|        P=0.200N         P=0.241          P=0.357          P=0.533          P=0.440N                         |
|COCH-ARM / FISHERS |        P=0.270N         P=0.173          P=0.260          P=0.373          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        3/60 (5%)        3/50 (6%)        1/50 (2%)        4/50 (8%)        7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        7.2%             7.0%             2.3%             9.7%             16.2%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        3/33 (9%)        1/34 (3%)        2/28 (7%)        4/28 (14%)                       |
|FIRST INCIDENCE    |        585              738 (T)          738 (T)          586              668                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.045 *        P=0.593N         P=0.263N         P=0.507          P=0.186                          |
|POLY 3             |        P=0.058          P=0.653N         P=0.296N         P=0.492          P=0.168                          |
|POLY 1.5           |        P=0.059          P=0.653          P=0.309N         P=0.483          P=0.161                          |
|POLY 6             |        P=0.056          P=0.637N         P=0.288N         P=0.485          P=0.176                          |
|LOGISTIC REGRESSION|        P=0.054          P=0.657N         P=0.311N         P=0.473          P=0.172                          |
|COCH-ARM / FISHERS |        P=0.067          P=0.570          P=0.381N         P=0.399          P=0.161                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 42
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        2/50 (4%)        2/50 (4%)        2/50 (4%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             5.5%             5.2%             4.6%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        2/21 (10%)       2/31 (7%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              663              736 (T)          736 (T)          ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.244N         P=0.259          P=0.367          P=0.463          (e)                              |
|POLY 3             |        P=0.400N         P=0.229          P=0.240          P=0.273          (e)                              |
|POLY 1.5           |        P=0.434N         P=0.226          P=0.233          P=0.249          (e)                              |
|POLY 6             |        P=0.348N         P=0.229          P=0.246          P=0.301          (e)                              |
|LOGISTIC REGRESSION|        P=0.340N         P=0.228          P=0.367          P=0.463          (e)                              |
|COCH-ARM / FISHERS |        P=0.469N         P=0.204          P=0.204          P=0.204          (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        2/50 (4%)        0/50 (0%)        1/60 (2%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             2.3%             4.7%             0.0%             2.3%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/28 (7%)        1/33 (3%)        2/34 (6%)        0/28 (0%)        1/28 (4%)                        |
|FIRST INCIDENCE    |        738 (T)          738 (T)          738 (T)          ---              738 (T)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.317N         P=0.442N         P=0.624N         P=0.238N         P=0.500N                         |
|POLY 3             |        P=0.296N         P=0.487N         P=0.679N         P=0.239N         P=0.488N                         |
|POLY 1.5           |        P=0.293N         P=0.505N         P=0.693          P=0.243N         P=0.496N                         |
|POLY 6             |        P=0.305N         P=0.471N         P=0.667N         P=0.242N         P=0.481N                         |
|LOGISTIC REGRESSION|        P=0.317N         P=0.442N         P=0.624N         (e)              P=0.500N                         |
|COCH-ARM / FISHERS |        P=0.295N         P=0.569N         P=0.619          P=0.295N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 43
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        10/50 (20%)      9/50 (18%)       8/50 (16%)       4/60 (7%)                        |
|POLY-3 ADJUSTED (b)|        12.8%            26.7%            22.8%            18.1%            9.5%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/12 (8%)        6/16 (38%)       5/21 (24%)       7/31 (23%)       3/27 (11%)                       |
|FIRST INCIDENCE    |        535              450              593              544              675                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.023N*        P=0.191          P=0.366          P=0.492N         P=0.235N                         |
|POLY 3             |        P=0.158N         P=0.104          P=0.194          P=0.361          P=0.452N                         |
|POLY 1.5           |        P=0.200N         P=0.104          P=0.179          P=0.303          P=0.477N                         |
|POLY 6             |        P=0.106N         P=0.095          P=0.203          P=0.426          P=0.410N                         |
|LOGISTIC REGRESSION|        P=0.155N         P=0.108          P=0.187          P=0.331          P=0.440N                         |
|COCH-ARM / FISHERS |        P=0.242N         P=0.067          P=0.110          P=0.173          P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        5/60 (8%)        4/50 (8%)        3/50 (6%)        4/50 (8%)        8/60 (13%)                       |
|POLY-3 ADJUSTED (b)|        11.9%            9.3%             7.0%             9.7%             18.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        3/28 (11%)       4/33 (12%)       3/34 (9%)        2/28 (7%)        5/28 (18%)                       |
|FIRST INCIDENCE    |        585              738 (T)          738 (T)          586              668                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.129          P=0.407N         P=0.273N         P=0.494N         P=0.304                          |
|POLY 3             |        P=0.162          P=0.487N         P=0.342N         P=0.509N         P=0.294                          |
|POLY 1.5           |        P=0.165          P=0.513N         P=0.363N         P=0.519N         P=0.281                          |
|POLY 6             |        P=0.157          P=0.465N         P=0.329N         P=0.518N         P=0.307                          |
|LOGISTIC REGRESSION|        P=0.155          P=0.467N         P=0.329N         P=0.520N         P=0.302                          |
|COCH-ARM / FISHERS |        P=0.180          P=0.615N         P=0.464N         P=0.615N         P=0.279                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 44
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        0/50 (0%)        2/60 (3%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.6%             0.0%             4.8%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        1/27 (4%)                        |
|FIRST INCIDENCE    |        ---              ---              688              ---              711                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.127          (e)              P=0.515          (e)              P=0.385                          |
|POLY 3             |        P=0.093          (e)              P=0.504          (e)              P=0.262                          |
|POLY 1.5           |        P=0.086          (e)              P=0.497          (e)              P=0.249                          |
|POLY 6             |        P=0.107          (e)              P=0.511          (e)              P=0.285                          |
|LOGISTIC REGRESSION|        P=0.092          (e)              P=0.502          (e)              P=0.312                          |
|COCH-ARM / FISHERS |        P=0.080          (e)              P=0.455          (e)              P=0.248                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        2.4%             2.3%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        1/28 (4%)        1/33 (3%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          738 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.164N         P=0.725N         P=0.461N         P=0.500N         P=0.500N                         |
|POLY 3             |        P=0.155N         P=0.753N         P=0.492N         P=0.503N         P=0.493N                         |
|POLY 1.5           |        P=0.155N         P=0.758          P=0.501N         P=0.506N         P=0.498N                         |
|POLY 6             |        P=0.158N         P=0.742N         P=0.485N         P=0.505N         P=0.489N                         |
|LOGISTIC REGRESSION|        P=0.164N         P=0.725N         (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.166N         P=0.705          P=0.545N         P=0.545N         P=0.500N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 45
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        1/50 (2%)        1/50 (2%)        1/50 (2%)        3/60 (5%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             2.8%             2.6%             2.3%             7.2%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        1/16 (6%)        0/21 (0%)        1/31 (3%)        2/27 (7%)                        |
|FIRST INCIDENCE    |        ---              736 (T)          688              736 (T)          711                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.143          P=0.557          P=0.515          P=0.689          P=0.267                          |
|POLY 3             |        P=0.078          P=0.492          P=0.504          P=0.529          P=0.139                          |
|POLY 1.5           |        P=0.069          P=0.490          P=0.497          P=0.510          P=0.128                          |
|POLY 6             |        P=0.093          P=0.491          P=0.511          P=0.551          P=0.158                          |
|LOGISTIC REGRESSION|        P=0.098          P=0.557          P=0.502          P=0.689          P=0.197                          |
|COCH-ARM / FISHERS |        P=0.062          P=0.455          P=0.455          P=0.455          P=0.122                          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                                                                             |
|-----------        |                                                                                                             |
|OVERALL (a)        |        2/60 (3%)        1/50 (2%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        4.8%             2.3%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        2/28 (7%)        1/33 (3%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        738 (T)          738 (T)          ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.061N         P=0.442N         P=0.196N         P=0.238N         P=0.238N                         |
|POLY 3             |        P=0.065N         P=0.487N         P=0.228N         P=0.239N         P=0.229N                         |
|POLY 1.5           |        P=0.064N         P=0.505N         P=0.238N         P=0.243N         P=0.234N                         |
|POLY 6             |        P=0.068N         P=0.471N         P=0.221N         P=0.242N         P=0.224N                         |
|LOGISTIC REGRESSION|        P=0.061N         P=0.442N         (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        P=0.065N         P=0.569N         P=0.295N         P=0.295N         P=0.248N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 46
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/60 (10%)       6/50 (12%)       3/50 (6%)        4/50 (8%)        6/60 (10%)                       |
|POLY-3 ADJUSTED (b)|        14.5%            14.0%            7.0%             9.7%             13.9%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/28 (21%)       4/33 (12%)       3/34 (9%)        3/28 (11%)       4/28 (14%)                       |
|FIRST INCIDENCE    |        738 (T)          715              738 (T)          592              600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.550          P=0.498N         P=0.151N         P=0.364N         P=0.611N                         |
|POLY 3             |        P=0.474N         P=0.594N         P=0.221N         P=0.369N         P=0.588N                         |
|POLY 1.5           |        P=0.476N         P=0.613          P=0.243N         P=0.384N         P=0.608N                         |
|POLY 6             |        P=0.477N         P=0.557N         P=0.204N         P=0.369N         P=0.566N                         |
|LOGISTIC REGRESSION|        P=0.498N         P=0.508N         P=0.151N         P=0.388N         P=0.581N                         |
|COCH-ARM / FISHERS |        P=0.474N         P=0.486          P=0.344N         P=0.491N         P=0.619N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 47
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |                                                                                                             |
|POLY-3 ADJUSTED (b)|                                                                                                             |
|INT SACRIFICE 1 (c)|                                                                                                             |
|TERMINAL (d)       |                                                                                                             |
|FIRST INCIDENCE    |                                                                                                             |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |                                                                                                             |
|POLY 3             |                                                                                                             |
|POLY 1.5           |                                                                                                             |
|POLY 6             |                                                                                                             |
|LOGISTIC REGRESSION|                                                                                                             |
|COCH-ARM / FISHERS |                                                                                                             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        6/60 (10%)       6/50 (12%)       4/50 (8%)        5/50 (10%)       7/60 (12%)                       |
|POLY-3 ADJUSTED (b)|        14.5%            14.0%            9.3%             12.1%            16.1%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        6/28 (21%)       4/33 (12%)       4/34 (12%)       4/28 (14%)       4/28 (14%)                       |
|FIRST INCIDENCE    |        738 (T)          715              738 (T)          592              600                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.384          P=0.498N         P=0.249N         P=0.497N         P=0.518                          |
|POLY 3             |        P=0.457          P=0.594N         P=0.343N         P=0.501N         P=0.541                          |
|POLY 1.5           |        P=0.453          P=0.613          P=0.371N         P=0.517N         P=0.517                          |
|POLY 6             |        P=0.459          P=0.557N         P=0.321N         P=0.503N         P=0.569                          |
|LOGISTIC REGRESSION|        P=0.438          P=0.508N         P=0.249N         P=0.525N         P=0.542                          |
|COCH-ARM / FISHERS |        P=0.465          P=0.486          P=0.491N         P=0.622          P=0.500                          |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 48
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        1/50 (2%)        2/50 (4%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             2.6%             4.6%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        1/31 (3%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              698              708              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.596          (e)              P=0.524          P=0.424          (e)                              |
|POLY 3             |        P=0.461          (e)              P=0.504          P=0.273          (e)                              |
|POLY 1.5           |        P=0.435          (e)              P=0.497          P=0.250          (e)                              |
|POLY 6             |        P=0.517          (e)              P=0.510          P=0.303          (e)                              |
|LOGISTIC REGRESSION|        P=0.520          (e)              P=0.507          P=0.320          (e)                              |
|COCH-ARM / FISHERS |        P=0.457          (e)              P=0.455          P=0.204          (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 49
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        25/60 (42%)      26/50 (52%)      26/50 (52%)      23/50 (46%)      15/60 (25%)                      |
|POLY-3 ADJUSTED (b)|        58.6%            61.5%            57.8%            48.9%            34.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/12 (42%)       8/16 (50%)       8/21 (38%)       11/31 (36%)      8/27 (30%)                       |
|FIRST INCIDENCE    |        561              507              482              518              536                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.544N         P=0.351N         P=0.013N*        P<0.001N**                       |
|POLY 3             |        P=0.004N**       P=0.476          P=0.560N         P=0.238N         P=0.017N*                        |
|POLY 1.5           |        P=0.007N**       P=0.430          P=0.513          P=0.358N         P=0.023N*                        |
|POLY 6             |        P=0.002N**       P=0.494          P=0.488N         P=0.155N         P=0.012N*                        |
|LOGISTIC REGRESSION|        P=0.005N**       P=0.398          P=0.439          P=0.316N         P=0.013N*                        |
|COCH-ARM / FISHERS |        P=0.013N*        P=0.187          P=0.187          P=0.396          P=0.040N*                        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        15/60 (25%)      15/50 (30%)      15/50 (30%)      18/50 (36%)      11/60 (18%)                      |
|POLY-3 ADJUSTED (b)|        33.8%            32.6%            32.0%            39.7%            24.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        5/28 (18%)       6/33 (18%)       7/34 (21%)       8/28 (29%)       2/28 (7%)                        |
|FIRST INCIDENCE    |        475              392              451              459              472                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.314N         P=0.436N         P=0.442N         P=0.345          P=0.231N                         |
|POLY 3             |        P=0.277N         P=0.542N         P=0.516N         P=0.356          P=0.222N                         |
|POLY 1.5           |        P=0.278N         P=0.577          P=0.577N         P=0.318          P=0.239N                         |
|POLY 6             |        P=0.279N         P=0.501N         P=0.476N         P=0.364          P=0.209N                         |
|LOGISTIC REGRESSION|        P=0.245N         P=0.468          P=0.450          P=0.225          P=0.238N                         |
|COCH-ARM / FISHERS |        P=0.236N         P=0.354          P=0.354          P=0.148          P=0.253N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 50
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        0/27 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        2/50 (4%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             4.9%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        1/28 (4%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              613              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.394          (e)              (e)              P=0.237          (e)                              |
|POLY 3             |        P=0.356          (e)              (e)              P=0.236          (e)                              |
|POLY 1.5           |        P=0.356          (e)              (e)              P=0.231          (e)                              |
|POLY 6             |        P=0.361          (e)              (e)              P=0.235          (e)                              |
|LOGISTIC REGRESSION|        P=0.408          (e)              (e)              P=0.219          (e)                              |
|COCH-ARM / FISHERS |        P=0.413          (e)              (e)              P=0.204          (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 51
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        1/60 (2%)        0/50 (0%)        2/50 (4%)        0/50 (0%)        9/60 (15%)                       |
|POLY-3 ADJUSTED (b)|        2.6%             0.0%             5.1%             0.0%             20.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/12 (0%)        0/16 (0%)        0/21 (0%)        0/31 (0%)        4/27 (15%)                       |
|FIRST INCIDENCE    |        617              ---              593              ---              502                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001 **       P=0.517N         P=0.490          P=0.470N         P=0.049 *                        |
|POLY 3             |        P<0.001 **       P=0.510N         P=0.509          P=0.473N         P=0.015 *                        |
|POLY 1.5           |        P<0.001 **       P=0.511N         P=0.496          P=0.491N         P=0.011 *                        |
|POLY 6             |        P<0.001 **       P=0.513N         P=0.521          P=0.453N         P=0.024 *                        |
|LOGISTIC REGRESSION|        P<0.001 **       P=0.533N         P=0.435          P=0.551N         P=0.013 *                        |
|COCH-ARM / FISHERS |        P<0.001 **       P=0.545N         P=0.431          P=0.545N         P=0.008 **                       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        0/60 (0%)        0/50 (0%)        0/50 (0%)        0/50 (0%)        0/60 (0%)                        |
|POLY-3 ADJUSTED (b)|        0.0%             0.0%             0.0%             0.0%             0.0%                             |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        0/28 (0%)        0/33 (0%)        0/34 (0%)        0/28 (0%)        0/28 (0%)                        |
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              |
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              |
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              |
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 52
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        48/60 (80%)      50/50 (100%)     48/50 (96%)      48/50 (96%)      47/60 (78%)                      |
|POLY-3 ADJUSTED (b)|        98.9%            100.0%           99.2%            98.7%            98.8%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        12/12 (100%)     16/16 (100%)     21/21 (100%)     31/31 (100%)     27/27 (100%)                     |
|FIRST INCIDENCE    |        396              410              443              518              502                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.499N         P=0.113N         P<0.001N**       P<0.001N**                       |
|POLY 3             |        P=0.457N         P=0.963          P=0.984          P=0.911N         P=0.991N                         |
|POLY 1.5           |        P=0.253N         P=0.062          P=0.423          P=0.451          P=0.757N                         |
|POLY 6             |        P=0.742N         P=1.000          P=1.000N         P=0.973N         P=1.000N                         |
|LOGISTIC REGRESSION|        P=0.096N         P=0.317          P=0.552N         P=0.463N         P=0.397N                         |
|COCH-ARM / FISHERS |        P=0.147N         P<0.001 **       P=0.011 *        P=0.011 *        P=0.500N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        37/60 (62%)      37/50 (74%)      27/50 (54%)      30/50 (60%)      35/60 (58%)                      |
|POLY-3 ADJUSTED (b)|        80.0%            81.7%            58.0%            67.5%            76.6%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        23/28 (82%)      28/33 (85%)      19/34 (56%)      20/28 (71%)      22/28 (79%)                      |
|FIRST INCIDENCE    |        507              522              417              417              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.425N         P=0.224N         P=0.011N*        P=0.168N         P=0.379N                         |
|POLY 3             |        P=0.249N         P=0.522          P=0.015N*        P=0.116N         P=0.442N                         |
|POLY 1.5           |        P=0.235N         P=0.437          P=0.028N*        P=0.140N         P=0.444N                         |
|POLY 6             |        P=0.291N         P=0.557          P=0.011N*        P=0.152N         P=0.465N                         |
|LOGISTIC REGRESSION|        P=0.218N         P=0.571N         P=0.029N*        P=0.105N         P=0.322N                         |
|COCH-ARM / FISHERS |        P=0.203N         P=0.121          P=0.268N         P=0.507N         P=0.426N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 53
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        32/60 (53%)      37/50 (74%)      36/50 (72%)      32/50 (64%)      30/60 (50%)                      |
|POLY-3 ADJUSTED (b)|        71.0%            81.3%            75.3%            67.3%            62.4%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        7/12 (58%)       11/16 (69%)      12/21 (57%)      18/31 (58%)      14/27 (52%)                      |
|FIRST INCIDENCE    |        396              450              360              518              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.392          P=0.429N         P=0.007N**       P=0.020N*                        |
|POLY 3             |        P=0.052N         P=0.166          P=0.405          P=0.435N         P=0.245N                         |
|POLY 1.5           |        P=0.080N         P=0.122          P=0.270          P=0.577N         P=0.305N                         |
|POLY 6             |        P=0.031N*        P=0.206          P=0.526          P=0.323N         P=0.184N                         |
|LOGISTIC REGRESSION|        P=0.102N         P=0.100          P=0.158          P=0.489N         P=0.329N                         |
|COCH-ARM / FISHERS |        P=0.145N         P=0.020 *        P=0.035 *        P=0.175          P=0.428N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        20/60 (33%)      18/50 (36%)      23/50 (46%)      24/50 (48%)      16/60 (27%)                      |
|POLY-3 ADJUSTED (b)|        45.1%            39.1%            48.6%            51.4%            34.2%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        10/28 (36%)      9/33 (27%)       12/34 (35%)      10/28 (36%)      3/28 (11%)                       |
|FIRST INCIDENCE    |        475              392              451              459              472                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.410N         P=0.268N         P=0.562          P=0.296          P=0.251N                         |
|POLY 3             |        P=0.303N         P=0.360N         P=0.448          P=0.346          P=0.197N                         |
|POLY 1.5           |        P=0.331N         P=0.429N         P=0.360          P=0.276          P=0.233N                         |
|POLY 6             |        P=0.271N         P=0.313N         P=0.516          P=0.392          P=0.162N                         |
|LOGISTIC REGRESSION|        P=0.321N         P=0.495N         P=0.276          P=0.180          P=0.252N                         |
|COCH-ARM / FISHERS |        P=0.301N         P=0.463          P=0.123          P=0.086          P=0.275N                         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 54
                     Statistical Analysis of Primary Tumors in Rats(FISCHER344)       -            PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Males                                                  |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        50/60 (83%)      50/50 (100%)     50/50 (100%)     48/50 (96%)      50/60 (83%)                      |
|POLY-3 ADJUSTED (b)|        99.7%            100.0%           100.0%           98.7%            99.5%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)                       |
|TERMINAL (d)       |        12/12 (100%)     16/16 (100%)     21/21 (100%)     31/31 (100%)     27/27 (100%)                     |
|FIRST INCIDENCE    |        396              410              360              518              184 (I)                          |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P<0.001N**       P=0.405N         P=0.120N         P<0.001N**       P=0.003N**                       |
|POLY 3             |        P=0.480N         P=1.000          P=1.000          P=0.804N         P=1.000N                         |
|POLY 1.5           |        P=0.235N         P=0.276          P=0.276          P=0.792          P=0.875N                         |
|POLY 6             |        P=0.794N         P=1.000          P=1.000          P=0.960N         P=1.000N                         |
|LOGISTIC REGRESSION|        P=0.565N         (e)              (e)              P=0.219N         P=0.608                          |
|COCH-ARM / FISHERS |        P=0.224N         P=0.002 **       P=0.002 **       P=0.032 *        P=0.596N                         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                                                      Females                                                |
|Dose               |        0 PPM            200 PPM          400 PPM       |  600 PPM          1000 PPM                         |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |        #                #                #                #                #                                |
|-----------        |                                                                                                             |
|OVERALL (a)        |        45/60 (75%)      43/50 (86%)      42/50 (84%)      43/50 (86%)      42/60 (70%)                      |
|POLY-3 ADJUSTED (b)|        93.9%            89.9%            85.4%            87.4%            86.3%                            |
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)                        |
|TERMINAL (d)       |        26/28 (93%)      29/33 (88%)      27/34 (79%)      22/28 (79%)      22/28 (79%)                      |
|FIRST INCIDENCE    |        475              392              417              417              365                              |
|-------------------|                                                                                                             |
|STATISTICAL TESTS  |                                                                                                             |
|-------------------|                                                                                                             |
|LIFE TABLE         |        P=0.488N         P=0.131N         P=0.100N         P=0.469N         P=0.315N                         |
|POLY 3             |        P=0.161N         P=0.361N         P=0.143N         P=0.218N         P=0.171N                         |
|POLY 1.5           |        P=0.190N         P=0.535N         P=0.289N         P=0.399N         P=0.231N                         |
|POLY 6             |        P=0.140N         P=0.308N         P=0.103N         P=0.165N         P=0.140N                         |
|LOGISTIC REGRESSION|        P=0.235N         P=0.509N         P=0.331N         P=0.490N         P=0.245N                         |
|COCH-ARM / FISHERS |        P=0.182N         P=0.115          P=0.179          P=0.115          P=0.342N                         |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).