TDMS Study 89002-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:13:34
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:13:34
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF PENTACHLOROPHENOL
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Brain Oligodendroglioma, Glioma, or Astrocytoma
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Intestine Small: Site Unspecified Carcinoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin Basal Cell Adenoma, Basosquamous Tumor Benign, or Trichoepithelioma
Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, malignant or NOS), or Trichoepithelioma
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom
Keratoacanthoma
Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
Trichoepithelioma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Mesothelioma: Benign, Malignant, NOS
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:13:34
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
Thyroid Gland: C-Cell Adenoma
All Organs Benign Tumors
===============================================================
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 1
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 14/60 (23%) 21/50 (42%) 20/50 (40%) 23/50 (46%) 16/60 (27%) |
|POLY-3 ADJUSTED (b)| 34.9% 53.7% 50.0% 52.3% 37.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/12 (42%) 11/16 (69%) 13/21 (62%) 19/31 (61%) 10/27 (37%) |
|FIRST INCIDENCE | 579 507 583 702 684 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009N** P=0.214 P=0.507 P=0.252N P=0.142N |
|POLY 3 | P=0.455N P=0.062 P=0.117 P=0.076 P=0.486 |
|POLY 1.5 | P=0.524 P=0.064 P=0.109 P=0.048 * P=0.447 |
|POLY 6 | P=0.327N P=0.049 * P=0.107 P=0.110 P=0.553 |
|LOGISTIC REGRESSION| P=0.211N P=0.067 P=0.153 P=0.221 P=0.556N |
|COCH-ARM / FISHERS | P=0.497 P=0.030 * P=0.047 * P=0.011 * P=0.417 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 3/50 (6%) 1/50 (2%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 7.0% 2.3% 2.5% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 3/33 (9%) 0/34 (0%) 1/28 (4%) 1/28 (4%) |
|FIRST INCIDENCE | --- 738 (T) 690 738 (T) 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.593 P=0.151 P=0.511 P=0.500 P=0.500 |
|POLY 3 | P=0.516N P=0.125 P=0.509 P=0.497 P=0.507 |
|POLY 1.5 | P=0.527N P=0.116 P=0.500 P=0.494 P=0.502 |
|POLY 6 | P=0.511N P=0.135 P=0.517 P=0.495 P=0.511 |
|LOGISTIC REGRESSION| P=0.581N P=0.151 P=0.495 P=0.500 P=0.500 |
|COCH-ARM / FISHERS | P=0.561N P=0.091 P=0.455 P=0.455 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 2
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 1/50 (2%) 3/50 (6%) 1/50 (2%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 2.7% 2.8% 7.9% 2.3% 7.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 1/16 (6%) 3/21 (14%) 1/31 (3%) 2/27 (7%) |
|FIRST INCIDENCE | 736 (T) 736 (T) 736 (T) 736 (T) 680 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.486 P=0.698N P=0.520 P=0.537N P=0.563 |
|POLY 3 | P=0.274 P=0.753 P=0.310 P=0.726N P=0.346 |
|POLY 1.5 | P=0.246 P=0.751 P=0.298 P=0.749N P=0.324 |
|POLY 6 | P=0.323 P=0.753 P=0.318 P=0.697N P=0.383 |
|LOGISTIC REGRESSION| P=0.384 P=0.698N P=0.520 P=0.537N P=0.424 |
|COCH-ARM / FISHERS | P=0.225 P=0.705 P=0.244 P=0.705 P=0.309 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 1/33 (3%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 738 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.464N P=0.533 (e) (e) (e) |
|POLY 3 | P=0.394N P=0.507 (e) (e) (e) |
|POLY 1.5 | P=0.402N P=0.497 (e) (e) (e) |
|POLY 6 | P=0.391N P=0.517 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.533 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.451N P=0.455 (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 3
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 16/60 (27%) 22/50 (44%) 21/50 (42%) 24/50 (48%) 18/60 (30%) |
|POLY-3 ADJUSTED (b)| 39.8% 55.1% 52.5% 54.5% 42.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/12 (50%) 11/16 (69%) 14/21 (67%) 20/31 (65%) 11/27 (41%) |
|FIRST INCIDENCE | 579 450 583 702 680 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007N** P=0.294 P=0.522N P=0.132N P=0.106N |
|POLY 3 | P=0.473N P=0.112 P=0.168 P=0.120 P=0.501 |
|POLY 1.5 | P=0.506 P=0.107 P=0.158 P=0.078 P=0.455 |
|POLY 6 | P=0.338N P=0.098 P=0.155 P=0.168 P=0.579 |
|LOGISTIC REGRESSION| P=0.228N P=0.103 P=0.216 P=0.340 P=0.519N |
|COCH-ARM / FISHERS | P=0.484 P=0.044 * P=0.068 P=0.017 * P=0.420 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 4/50 (8%) 1/50 (2%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 9.3% 2.3% 2.5% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 4/33 (12%) 0/34 (0%) 1/28 (4%) 1/28 (4%) |
|FIRST INCIDENCE | --- 738 (T) 690 738 (T) 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.490N P=0.085 P=0.511 P=0.500 P=0.500 |
|POLY 3 | P=0.395N P=0.065 P=0.509 P=0.497 P=0.507 |
|POLY 1.5 | P=0.409N P=0.058 P=0.500 P=0.494 P=0.502 |
|POLY 6 | P=0.387N P=0.072 P=0.517 P=0.495 P=0.511 |
|LOGISTIC REGRESSION| P=0.470N P=0.085 P=0.495 P=0.500 P=0.500 |
|COCH-ARM / FISHERS | P=0.453N P=0.040 * P=0.455 P=0.455 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 4
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 2.3% 4.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- 563 610 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.111 (e) P=0.495 P=0.539 P=0.240 |
|POLY 3 | P=0.091 (e) P=0.506 P=0.531 P=0.272 |
|POLY 1.5 | P=0.081 (e) P=0.498 P=0.512 P=0.257 |
|POLY 6 | P=0.110 (e) P=0.513 P=0.554 P=0.296 |
|LOGISTIC REGRESSION| P=0.121 (e) P=0.422 P=0.443 P=0.234 |
|COCH-ARM / FISHERS | P=0.075 (e) P=0.455 P=0.455 P=0.248 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.3% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 544 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.671N (e) P=0.509 (e) (e) |
|POLY 3 | P=0.653N (e) P=0.511 (e) (e) |
|POLY 1.5 | P=0.653N (e) P=0.501 (e) (e) |
|POLY 6 | P=0.658N (e) P=0.519 (e) (e) |
|LOGISTIC REGRESSION| P=0.645N (e) P=0.384 (e) (e) |
|COCH-ARM / FISHERS | P=0.668N (e) P=0.455 (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 5
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 2.3% 6.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- 563 610 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.039 * (e) P=0.495 P=0.539 P=0.125 |
|POLY 3 | P=0.030 * (e) P=0.506 P=0.531 P=0.151 |
|POLY 1.5 | P=0.026 * (e) P=0.498 P=0.512 P=0.137 |
|POLY 6 | P=0.039 * (e) P=0.513 P=0.554 P=0.174 |
|LOGISTIC REGRESSION| P=0.045 * (e) P=0.422 P=0.443 P=0.112 |
|COCH-ARM / FISHERS | P=0.023 * (e) P=0.455 P=0.455 P=0.122 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.3% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 544 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.671N (e) P=0.509 (e) (e) |
|POLY 3 | P=0.653N (e) P=0.511 (e) (e) |
|POLY 1.5 | P=0.653N (e) P=0.501 (e) (e) |
|POLY 6 | P=0.658N (e) P=0.519 (e) (e) |
|LOGISTIC REGRESSION| P=0.645N (e) P=0.384 (e) (e) |
|COCH-ARM / FISHERS | P=0.668N (e) P=0.455 (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 6
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/60 (7%) 1/50 (2%) 3/50 (6%) 1/50 (2%) 4/59 (7%) |
|POLY-3 ADJUSTED (b)| 10.5% 2.7% 7.7% 2.3% 9.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 2/21 (10%) 0/31 (0%) 2/27 (7%) |
|FIRST INCIDENCE | 647 450 521 544 550 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.444N P=0.177N P=0.372N P=0.085N P=0.408N |
|POLY 3 | P=0.531 P=0.187N P=0.492N P=0.139N P=0.592N |
|POLY 1.5 | P=0.500 P=0.191N P=0.509N P=0.163N P=0.623N |
|POLY 6 | P=0.547N P=0.189N P=0.483N P=0.116N P=0.541N |
|LOGISTIC REGRESSION| P=0.488 P=0.211N P=0.504N P=0.184N P=0.618N |
|COCH-ARM / FISHERS | P=0.484 P=0.244N P=0.601N P=0.244N P=0.632 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/60 (7%) 1/50 (2%) 1/48 (2%) 3/50 (6%) 5/59 (8%) |
|POLY-3 ADJUSTED (b)| 9.6% 2.3% 2.4% 7.1% 11.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/28 (11%) 0/33 (0%) 1/34 (3%) 1/28 (4%) 1/27 (4%) |
|FIRST INCIDENCE | 645 701 738 (T) 417 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.188 P=0.143N P=0.136N P=0.507N P=0.510 |
|POLY 3 | P=0.190 P=0.169N P=0.179N P=0.495N P=0.521 |
|POLY 1.5 | P=0.195 P=0.183N P=0.192N P=0.509N P=0.503 |
|POLY 6 | P=0.184 P=0.156N P=0.169N P=0.497N P=0.538 |
|LOGISTIC REGRESSION| P=0.215 P=0.166N P=0.169N P=0.562N P=0.496 |
|COCH-ARM / FISHERS | P=0.221 P=0.244N P=0.259N P=0.601N P=0.489 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 7
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 7/50 (14%) 1/50 (2%) 0/50 (0%) 2/59 (3%) |
|POLY-3 ADJUSTED (b)| 2.6% 18.8% 2.6% 0.0% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 3/16 (19%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 396 544 360 --- 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.105N P=0.054 P=0.758 P=0.504N P=0.588 |
|POLY 3 | P=0.137N P=0.025 * P=0.758N P=0.475N P=0.527 |
|POLY 1.5 | P=0.159N P=0.024 * P=0.758 P=0.492N P=0.509 |
|POLY 6 | P=0.114N P=0.024 * P=0.753N P=0.455N P=0.559 |
|LOGISTIC REGRESSION| P=0.231N P=0.024 * P=0.469 P=0.760N P=0.490 |
|COCH-ARM / FISHERS | P=0.228N P=0.016 * P=0.705 P=0.545N P=0.494 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 2/48 (4%) 0/50 (0%) 1/59 (2%) |
|POLY-3 ADJUSTED (b)| 4.8% 2.3% 4.8% 0.0% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 0/33 (0%) 1/34 (3%) 0/28 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 715 700 670 --- 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.307N P=0.434N P=0.631N P=0.243N P=0.489N |
|POLY 3 | P=0.301N P=0.487N P=0.692N P=0.240N P=0.493N |
|POLY 1.5 | P=0.298N P=0.504N P=0.680 P=0.244N P=0.502N |
|POLY 6 | P=0.310N P=0.470N P=0.677N P=0.243N P=0.485N |
|LOGISTIC REGRESSION| P=0.302N P=0.480N P=0.692N P=0.245N P=0.500N |
|COCH-ARM / FISHERS | P=0.300N P=0.569N P=0.603 P=0.295N P=0.506N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 8
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/60 (8%) 8/50 (16%) 4/50 (8%) 1/50 (2%) 5/59 (8%) |
|POLY-3 ADJUSTED (b)| 12.8% 21.0% 10.1% 2.3% 11.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 3/16 (19%) 2/21 (10%) 0/31 (0%) 2/27 (7%) |
|FIRST INCIDENCE | 396 450 360 544 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.082N P=0.346 P=0.389N P=0.048N* P=0.420N |
|POLY 3 | P=0.150N P=0.251 P=0.490N P=0.076N P=0.576N |
|POLY 1.5 | P=0.180N P=0.245 P=0.510N P=0.093N P=0.611N |
|POLY 6 | P=0.117N P=0.248 P=0.481N P=0.061N P=0.519N |
|LOGISTIC REGRESSION| P=0.238N P=0.217 P=0.624N P=0.150N P=0.626N |
|COCH-ARM / FISHERS | P=0.237N P=0.173 P=0.615N P=0.151N P=0.618 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 6/60 (10%) 2/50 (4%) 3/48 (6%) 3/50 (6%) 6/59 (10%) |
|POLY-3 ADJUSTED (b)| 14.4% 4.6% 7.2% 7.1% 13.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/28 (14%) 0/33 (0%) 2/34 (6%) 1/28 (4%) 1/27 (4%) |
|FIRST INCIDENCE | 645 700 670 417 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.370 P=0.095N P=0.173N P=0.255N P=0.602N |
|POLY 3 | P=0.380 P=0.121N P=0.241N P=0.236N P=0.592N |
|POLY 1.5 | P=0.384 P=0.137N P=0.264N P=0.249N P=0.614N |
|POLY 6 | P=0.371 P=0.108N P=0.223N P=0.238N P=0.570N |
|LOGISTIC REGRESSION| P=0.400 P=0.118N P=0.230N P=0.279N P=0.617 |
|COCH-ARM / FISHERS | P=0.411 P=0.203N P=0.368N P=0.344N P=0.607 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 9
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- --- --- 614 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.046 * (e) (e) (e) P=0.339 |
|POLY 3 | P=0.038 * (e) (e) (e) P=0.264 |
|POLY 1.5 | P=0.036 * (e) (e) (e) P=0.250 |
|POLY 6 | P=0.041 * (e) (e) (e) P=0.288 |
|LOGISTIC REGRESSION| P=0.034 * (e) (e) (e) P=0.254 |
|COCH-ARM / FISHERS | P=0.036 * (e) (e) (e) P=0.248 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.3% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 625 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.673N (e) P=0.510 (e) (e) |
|POLY 3 | P=0.653N (e) P=0.510 (e) (e) |
|POLY 1.5 | P=0.653N (e) P=0.500 (e) (e) |
|POLY 6 | P=0.658N (e) P=0.518 (e) (e) |
|LOGISTIC REGRESSION| P=0.664N (e) P=0.451 (e) (e) |
|COCH-ARM / FISHERS | P=0.668N (e) P=0.455 (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 10
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 2/48 (4%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 4.8% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 2/30 (7%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- --- 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.241 (e) (e) P=0.455 P=0.662 |
|POLY 3 | P=0.133 (e) (e) P=0.262 P=0.521 |
|POLY 1.5 | P=0.124 (e) (e) P=0.239 P=0.510 |
|POLY 6 | P=0.157 (e) (e) P=0.290 P=0.539 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.455 P=0.662 |
|COCH-ARM / FISHERS | P=0.139 (e) (e) P=0.195 P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.245N P=0.467N P=0.461N P=0.500N P=0.500N |
|POLY 3 | P=0.259N P=0.497N P=0.492N P=0.503N P=0.493N |
|POLY 1.5 | P=0.251N P=0.507N P=0.501N P=0.506N P=0.498N |
|POLY 6 | P=0.270N P=0.487N P=0.485N P=0.505N P=0.489N |
|LOGISTIC REGRESSION| P=0.245N (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.247N P=0.550N P=0.545N P=0.545N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 11
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 2.7% 2.8% 0.0% 0.0% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 0/31 (0%) 2/27 (7%) |
|FIRST INCIDENCE | 695 736 (T) --- --- 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.560 P=0.729N P=0.484N P=0.408N P=0.722 |
|POLY 3 | P=0.404 P=0.753 P=0.498N P=0.471N P=0.536 |
|POLY 1.5 | P=0.392 P=0.750 P=0.504N P=0.490N P=0.517 |
|POLY 6 | P=0.422 P=0.751 P=0.493N P=0.451N P=0.566 |
|LOGISTIC REGRESSION| P=0.483 P=0.760 P=0.495N P=0.474N P=0.617 |
|COCH-ARM / FISHERS | P=0.377 P=0.705 P=0.545N P=0.545N P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 12
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 4.6% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 2/31 (7%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- 736 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.559 (e) (e) P=0.463 (e) |
|POLY 3 | P=0.389 (e) (e) P=0.273 (e) |
|POLY 1.5 | P=0.373 (e) (e) P=0.249 (e) |
|POLY 6 | P=0.436 (e) (e) P=0.301 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.463 (e) |
|COCH-ARM / FISHERS | P=0.413 (e) (e) P=0.204 (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 13
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 2.7% 2.8% 0.0% 4.6% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 2/31 (7%) 2/27 (7%) |
|FIRST INCIDENCE | 695 736 (T) --- 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.485 P=0.729N P=0.484N P=0.713N P=0.722 |
|POLY 3 | P=0.281 P=0.753 P=0.498N P=0.550 P=0.536 |
|POLY 1.5 | P=0.266 P=0.750 P=0.504N P=0.518 P=0.517 |
|POLY 6 | P=0.313 P=0.751 P=0.493N P=0.586 P=0.566 |
|LOGISTIC REGRESSION| P=0.402 P=0.760 P=0.495N P=0.638 P=0.617 |
|COCH-ARM / FISHERS | P=0.269 P=0.705 P=0.545N P=0.431 P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 14
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.5% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 2/16 (13%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 736 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.156N P=0.302 (e) (e) (e) |
|POLY 3 | P=0.219N P=0.227 (e) (e) (e) |
|POLY 1.5 | P=0.231N P=0.225 (e) (e) (e) |
|POLY 6 | P=0.211N P=0.225 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.302 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.284N P=0.204 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 4.8% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 645 --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.082N P=0.216N P=0.216N P=0.255N P=0.232N |
|POLY 3 | P=0.097N P=0.231N P=0.230N P=0.241N P=0.231N |
|POLY 1.5 | P=0.092N P=0.241N P=0.239N P=0.244N P=0.235N |
|POLY 6 | P=0.103N P=0.222N P=0.224N P=0.245N P=0.228N |
|LOGISTIC REGRESSION| P=0.082N P=0.240N P=0.239N P=0.246N P=0.232N |
|COCH-ARM / FISHERS | P=0.086N P=0.295N P=0.295N P=0.295N P=0.248N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 15
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.5% 2.6% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 2/16 (13%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 736 (T) 688 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.165N P=0.302 P=0.515 (e) (e) |
|POLY 3 | P=0.223N P=0.227 P=0.504 (e) (e) |
|POLY 1.5 | P=0.242N P=0.225 P=0.497 (e) (e) |
|POLY 6 | P=0.204N P=0.225 P=0.511 (e) (e) |
|LOGISTIC REGRESSION| P=0.220N P=0.302 P=0.502 (e) (e) |
|COCH-ARM / FISHERS | P=0.295N P=0.204 P=0.455 (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/60 (5%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 7.2% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/28 (7%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 645 --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.030N* P=0.101N P=0.099N P=0.131N P=0.118N |
|POLY 3 | P=0.039N* P=0.114N P=0.113N P=0.122N P=0.114N |
|POLY 1.5 | P=0.037N* P=0.122N P=0.120N P=0.124N P=0.117N |
|POLY 6 | P=0.043N* P=0.107N P=0.108N P=0.124N P=0.111N |
|LOGISTIC REGRESSION| P=0.029N* P=0.115N P=0.114N P=0.124N P=0.114N |
|COCH-ARM / FISHERS | P=0.033N* P=0.159N P=0.159N P=0.159N P=0.122N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 16
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 736 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.341N P=0.557 (e) (e) (e) |
|POLY 3 | P=0.390N P=0.492 (e) (e) (e) |
|POLY 1.5 | P=0.399N P=0.490 (e) (e) (e) |
|POLY 6 | P=0.388N P=0.491 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.557 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.451N P=0.455 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/60 (2%) 3/50 (6%) 2/50 (4%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 6.9% 4.7% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 2/33 (6%) 2/34 (6%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) 430 738 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.111N P=0.347 P=0.568 P=0.500N P=0.500N |
|POLY 3 | P=0.088N P=0.325 P=0.514 P=0.503N P=0.493N |
|POLY 1.5 | P=0.092N P=0.305 P=0.499 P=0.506N P=0.498N |
|POLY 6 | P=0.088N P=0.345 P=0.526 P=0.505N P=0.489N |
|LOGISTIC REGRESSION| P=0.107N P=0.261 P=0.568 (e) (e) |
|COCH-ARM / FISHERS | P=0.110N P=0.244 P=0.431 P=0.545N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 17
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 736 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.341N P=0.557 (e) (e) (e) |
|POLY 3 | P=0.390N P=0.492 (e) (e) (e) |
|POLY 1.5 | P=0.399N P=0.490 (e) (e) (e) |
|POLY 6 | P=0.388N P=0.491 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.557 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.451N P=0.455 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/60 (2%) 3/50 (6%) 3/50 (6%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 6.9% 7.0% 2.5% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 2/33 (6%) 3/34 (9%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) 430 738 (T) 738 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.180N P=0.347 P=0.376 P=0.762 P=0.500N |
|POLY 3 | P=0.152N P=0.325 P=0.320 P=0.759 P=0.493N |
|POLY 1.5 | P=0.156N P=0.305 P=0.304 P=0.755 P=0.498N |
|POLY 6 | P=0.151N P=0.345 P=0.332 P=0.756 P=0.489N |
|LOGISTIC REGRESSION| P=0.167N P=0.261 P=0.376 P=0.762 (e) |
|COCH-ARM / FISHERS | P=0.169N P=0.244 P=0.244 P=0.705 P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 18
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 5/60 (8%) 5/50 (10%) 4/50 (8%) 2/50 (4%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 13.0% 13.8% 10.4% 4.6% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 3/16 (19%) 3/21 (14%) 2/31 (7%) 1/27 (4%) |
|FIRST INCIDENCE | 619 698 698 736 (T) 715 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009N** P=0.544N P=0.329N P=0.052N P=0.081N |
|POLY 3 | P=0.056N P=0.595 P=0.503N P=0.169N P=0.181N |
|POLY 1.5 | P=0.069N P=0.594 P=0.518N P=0.200N P=0.199N |
|POLY 6 | P=0.041N* P=0.582 P=0.500N P=0.140N P=0.156N |
|LOGISTIC REGRESSION| P=0.030N* P=0.608 P=0.475N P=0.154N P=0.165N |
|COCH-ARM / FISHERS | P=0.087N P=0.509 P=0.615N P=0.301N P=0.219N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 25/60 (42%) 20/50 (40%) 19/50 (38%) 12/50 (24%) 15/60 (25%) |
|POLY-3 ADJUSTED (b)| 56.5% 45.7% 41.9% 28.6% 34.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 16/28 (57%) 16/33 (49%) 14/34 (41%) 7/28 (25%) 11/28 (39%) |
|FIRST INCIDENCE | 507 620 417 634 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.023N* P=0.087N P=0.063N P=0.013N* P=0.036N* |
|POLY 3 | P=0.010N* P=0.207N P=0.115N P=0.006N** P=0.027N* |
|POLY 1.5 | P=0.010N* P=0.254N P=0.156N P=0.007N** P=0.030N* |
|POLY 6 | P=0.012N* P=0.178N P=0.095N P=0.007N** P=0.025N* |
|LOGISTIC REGRESSION| P=0.008N** P=0.162N P=0.146N P=0.007N** P=0.020N* |
|COCH-ARM / FISHERS | P=0.010N* P=0.507N P=0.423N P=0.039N* P=0.040N* |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 19
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 5/60 (8%) 5/50 (10%) 4/50 (8%) 2/50 (4%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 13.0% 13.8% 10.4% 4.6% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 3/16 (19%) 3/21 (14%) 2/31 (7%) 1/27 (4%) |
|FIRST INCIDENCE | 619 698 698 736 (T) 715 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009N** P=0.544N P=0.329N P=0.052N P=0.081N |
|POLY 3 | P=0.056N P=0.595 P=0.503N P=0.169N P=0.181N |
|POLY 1.5 | P=0.069N P=0.594 P=0.518N P=0.200N P=0.199N |
|POLY 6 | P=0.041N* P=0.582 P=0.500N P=0.140N P=0.156N |
|LOGISTIC REGRESSION| P=0.030N* P=0.608 P=0.475N P=0.154N P=0.165N |
|COCH-ARM / FISHERS | P=0.087N P=0.509 P=0.615N P=0.301N P=0.219N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 25/60 (42%) 20/50 (40%) 19/50 (38%) 13/50 (26%) 15/60 (25%) |
|POLY-3 ADJUSTED (b)| 56.5% 45.7% 41.9% 31.0% 34.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 16/28 (57%) 16/33 (49%) 14/34 (41%) 8/28 (29%) 11/28 (39%) |
|FIRST INCIDENCE | 507 620 417 634 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.026N* P=0.087N P=0.063N P=0.022N* P=0.036N* |
|POLY 3 | P=0.013N* P=0.207N P=0.115N P=0.011N* P=0.027N* |
|POLY 1.5 | P=0.012N* P=0.254N P=0.156N P=0.014N* P=0.030N* |
|POLY 6 | P=0.015N* P=0.178N P=0.095N P=0.013N* P=0.025N* |
|LOGISTIC REGRESSION| P=0.010N* P=0.162N P=0.146N P=0.012N* P=0.020N* |
|COCH-ARM / FISHERS | P=0.012N* P=0.507N P=0.423N P=0.064N P=0.040N* |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 20
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 5/60 (8%) 5/50 (10%) 4/50 (8%) 2/50 (4%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 13.0% 13.8% 10.4% 4.6% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 3/16 (19%) 3/21 (14%) 2/31 (7%) 1/27 (4%) |
|FIRST INCIDENCE | 619 698 698 736 (T) 715 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009N** P=0.544N P=0.329N P=0.052N P=0.081N |
|POLY 3 | P=0.056N P=0.595 P=0.503N P=0.169N P=0.181N |
|POLY 1.5 | P=0.069N P=0.594 P=0.518N P=0.200N P=0.199N |
|POLY 6 | P=0.041N* P=0.582 P=0.500N P=0.140N P=0.156N |
|LOGISTIC REGRESSION| P=0.030N* P=0.608 P=0.475N P=0.154N P=0.165N |
|COCH-ARM / FISHERS | P=0.087N P=0.509 P=0.615N P=0.301N P=0.219N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 25/60 (42%) 22/50 (44%) 21/50 (42%) 13/50 (26%) 15/60 (25%) |
|POLY-3 ADJUSTED (b)| 56.5% 49.4% 46.3% 31.0% 34.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 16/28 (57%) 17/33 (52%) 16/34 (47%) 8/28 (29%) 11/28 (39%) |
|FIRST INCIDENCE | 507 430 417 634 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.017N* P=0.164N P=0.115N P=0.022N* P=0.036N* |
|POLY 3 | P=0.008N** P=0.320N P=0.220N P=0.011N* P=0.027N* |
|POLY 1.5 | P=0.007N** P=0.387N P=0.279N P=0.014N* P=0.030N* |
|POLY 6 | P=0.009N** P=0.277N P=0.191N P=0.013N* P=0.025N* |
|LOGISTIC REGRESSION| P=0.006N** P=0.314N P=0.252N P=0.012N* P=0.020N* |
|COCH-ARM / FISHERS | P=0.007N** P=0.479 P=0.563 P=0.064N P=0.040N* |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 21
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Squamous Cell Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 3/50 (6%) 1/50 (2%) 0/50 (0%) 5/60 (8%) |
|POLY-3 ADJUSTED (b)| 2.6% 8.1% 2.6% 0.0% 11.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 2/27 (7%) |
|FIRST INCIDENCE | 643 505 593 --- 460 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.177 P=0.301 P=0.744 P=0.473N P=0.210 |
|POLY 3 | P=0.150 P=0.297 P=0.757N P=0.472N P=0.133 |
|POLY 1.5 | P=0.135 P=0.291 P=0.758 P=0.490N P=0.117 |
|POLY 6 | P=0.171 P=0.299 P=0.751N P=0.452N P=0.162 |
|LOGISTIC REGRESSION| P=0.111 P=0.253 P=0.730 P=0.527N P=0.112 |
|COCH-ARM / FISHERS | P=0.111 P=0.244 P=0.705 P=0.545N P=0.103 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Squamous Cell Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 22
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 2.6% 0.0% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 2/27 (7%) |
|FIRST INCIDENCE | 702 --- 640 --- 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.513N P=0.204N P=0.423N P=0.094N P=0.419N |
|POLY 3 | P=0.527 P=0.245N P=0.492N P=0.208N P=0.657N |
|POLY 1.5 | P=0.511 P=0.248N P=0.505N P=0.226N P=0.676N |
|POLY 6 | P=0.552 P=0.246N P=0.482N P=0.188N P=0.624N |
|LOGISTIC REGRESSION| P=0.584 P=0.237N P=0.492N P=0.159N P=0.541N |
|COCH-ARM / FISHERS | P=0.511 P=0.295N P=0.569N P=0.295N P=0.691N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 4.8% 0.0% 0.0% 0.0% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/28 (7%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) --- --- --- 724 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.439N P=0.202N P=0.196N P=0.238N P=0.500N |
|POLY 3 | P=0.440N P=0.229N P=0.228N P=0.239N P=0.488N |
|POLY 1.5 | P=0.428N P=0.240N P=0.238N P=0.243N P=0.496N |
|POLY 6 | P=0.457N P=0.219N P=0.221N P=0.242N P=0.480N |
|LOGISTIC REGRESSION| P=0.426N (e) (e) (e) P=0.482N |
|COCH-ARM / FISHERS | P=0.414N P=0.295N P=0.295N P=0.295N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 23
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 2.6% 2.3% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 2/27 (7%) |
|FIRST INCIDENCE | 702 --- 640 605 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.578N P=0.204N P=0.423N P=0.305N P=0.419N |
|POLY 3 | P=0.450 P=0.245N P=0.492N P=0.446N P=0.657N |
|POLY 1.5 | P=0.431 P=0.248N P=0.505N P=0.480N P=0.676N |
|POLY 6 | P=0.484 P=0.246N P=0.482N P=0.408N P=0.624N |
|LOGISTIC REGRESSION| P=0.477 P=0.237N P=0.492N P=0.482N P=0.541N |
|COCH-ARM / FISHERS | P=0.439 P=0.295N P=0.569N P=0.569N P=0.691N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 4.8% 0.0% 0.0% 0.0% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/28 (7%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) --- --- --- 701 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.461 P=0.202N P=0.196N P=0.238N P=0.679N |
|POLY 3 | P=0.449 P=0.229N P=0.228N P=0.239N P=0.681N |
|POLY 1.5 | P=0.460 P=0.240N P=0.238N P=0.243N P=0.689N |
|POLY 6 | P=0.437 P=0.219N P=0.221N P=0.242N P=0.671N |
|LOGISTIC REGRESSION| P=0.477 (e) (e) (e) P=0.675N |
|COCH-ARM / FISHERS | P=0.488 P=0.295N P=0.295N P=0.295N P=0.691N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 24
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 1/50 (2%) 0/48 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 2.6% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 1/21 (5%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 660 --- 736 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.052N P=0.219N P=0.380N P=0.123N P=0.132N |
|POLY 3 | P=0.110N P=0.246N P=0.497N P=0.217N P=0.215N |
|POLY 1.5 | P=0.116N P=0.248N P=0.508N P=0.236N P=0.226N |
|POLY 6 | P=0.103N P=0.248N P=0.490N P=0.198N P=0.198N |
|LOGISTIC REGRESSION| P=0.084N P=0.246N P=0.477N P=0.207N P=0.204N |
|COCH-ARM / FISHERS | P=0.119N P=0.295N P=0.569N P=0.306N P=0.248N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE | --- --- --- --- 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.134 (e) (e) (e) P=0.500 |
|POLY 3 | P=0.152 (e) (e) (e) P=0.507 |
|POLY 1.5 | P=0.153 (e) (e) (e) P=0.502 |
|POLY 6 | P=0.152 (e) (e) (e) P=0.511 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.161 (e) (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 25
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 18/60 (30%) 16/50 (32%) 14/49 (29%) 13/50 (26%) 16/60 (27%) |
|POLY-3 ADJUSTED (b)| 41.3% 40.1% 34.4% 29.5% 36.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/12 (33%) 6/16 (38%) 5/21 (24%) 11/31 (36%) 7/27 (26%) |
|FIRST INCIDENCE | 396 524 443 620 565 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.020N* P=0.372N P=0.142N P=0.006N** P=0.082N |
|POLY 3 | P=0.252N P=0.545N P=0.331N P=0.171N P=0.400N |
|POLY 1.5 | P=0.288N P=0.530N P=0.343N P=0.208N P=0.420N |
|POLY 6 | P=0.193N P=0.588N P=0.342N P=0.144N P=0.348N |
|LOGISTIC REGRESSION| P=0.229N P=0.553N P=0.390N P=0.201N P=0.348N |
|COCH-ARM / FISHERS | P=0.295N P=0.492 P=0.520N P=0.402N P=0.420N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 22/60 (37%) 20/50 (40%) 14/50 (28%) 16/50 (32%) 18/60 (30%) |
|POLY-3 ADJUSTED (b)| 48.9% 44.9% 31.5% 38.1% 41.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 11/28 (39%) 15/33 (46%) 10/34 (29%) 11/28 (39%) 13/28 (46%) |
|FIRST INCIDENCE | 507 522 544 592 652 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.279N P=0.247N P=0.039N* P=0.197N P=0.262N |
|POLY 3 | P=0.240N P=0.431N P=0.068N P=0.205N P=0.305N |
|POLY 1.5 | P=0.218N P=0.479N P=0.082N P=0.203N P=0.298N |
|POLY 6 | P=0.281N P=0.409N P=0.065N P=0.255N P=0.330N |
|LOGISTIC REGRESSION| P=0.182N P=0.434N P=0.073N P=0.170N P=0.223N |
|COCH-ARM / FISHERS | P=0.174N P=0.435 P=0.224N P=0.379N P=0.281N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 26
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 18/60 (30%) 16/50 (32%) 14/49 (29%) 14/50 (28%) 16/60 (27%) |
|POLY-3 ADJUSTED (b)| 41.3% 40.1% 34.4% 31.8% 36.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/12 (33%) 6/16 (38%) 5/21 (24%) 12/31 (39%) 7/27 (26%) |
|FIRST INCIDENCE | 396 524 443 620 565 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.022N* P=0.372N P=0.142N P=0.008N** P=0.082N |
|POLY 3 | P=0.277N P=0.545N P=0.331N P=0.236N P=0.400N |
|POLY 1.5 | P=0.314N P=0.530N P=0.343N P=0.280N P=0.420N |
|POLY 6 | P=0.214N P=0.588N P=0.342N P=0.204N P=0.348N |
|LOGISTIC REGRESSION| P=0.246N P=0.553N P=0.390N P=0.261N P=0.348N |
|COCH-ARM / FISHERS | P=0.316N P=0.492 P=0.520N P=0.493N P=0.420N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 22/60 (37%) 20/50 (40%) 14/50 (28%) 16/50 (32%) 18/60 (30%) |
|POLY-3 ADJUSTED (b)| 48.9% 44.9% 31.5% 38.1% 41.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 11/28 (39%) 15/33 (46%) 10/34 (29%) 11/28 (39%) 13/28 (46%) |
|FIRST INCIDENCE | 507 522 544 592 652 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.279N P=0.247N P=0.039N* P=0.197N P=0.262N |
|POLY 3 | P=0.240N P=0.431N P=0.068N P=0.205N P=0.305N |
|POLY 1.5 | P=0.218N P=0.479N P=0.082N P=0.203N P=0.298N |
|POLY 6 | P=0.281N P=0.409N P=0.065N P=0.255N P=0.330N |
|LOGISTIC REGRESSION| P=0.182N P=0.434N P=0.073N P=0.170N P=0.223N |
|COCH-ARM / FISHERS | P=0.174N P=0.435 P=0.224N P=0.379N P=0.281N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 27
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 2.6% 0.0% 0.0% 0.0% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 684 --- --- --- 592 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.292 P=0.515N P=0.500N P=0.427N P=0.628 |
|POLY 3 | P=0.228 P=0.509N P=0.498N P=0.472N P=0.539 |
|POLY 1.5 | P=0.222 P=0.510N P=0.504N P=0.490N P=0.519 |
|POLY 6 | P=0.240 P=0.511N P=0.494N P=0.451N P=0.572 |
|LOGISTIC REGRESSION| P=0.228 P=0.510N P=0.499N P=0.487N P=0.526 |
|COCH-ARM / FISHERS | P=0.225 P=0.545N P=0.545N P=0.545N P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 28
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma, Basosquamous Tumor Benign, or |
| Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 2.6% 0.0% 0.0% 0.0% 9.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 684 --- --- --- 592 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.042 * P=0.515N P=0.500N P=0.427N P=0.312 |
|POLY 3 | P=0.024 * P=0.509N P=0.498N P=0.472N P=0.217 |
|POLY 1.5 | P=0.023 * P=0.510N P=0.504N P=0.490N P=0.197 |
|POLY 6 | P=0.027 * P=0.511N P=0.494N P=0.451N P=0.253 |
|LOGISTIC REGRESSION| P=0.023 * P=0.510N P=0.499N P=0.487N P=0.204 |
|COCH-ARM / FISHERS | P=0.023 * P=0.545N P=0.545N P=0.545N P=0.182 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma, Basosquamous Tumor Benign, or |
| Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 29
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous |
| Tumor (benign, malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 2.6% 0.0% 2.6% 0.0% 9.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 684 --- 736 (T) --- 592 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.076 P=0.515N P=0.700N P=0.427N P=0.312 |
|POLY 3 | P=0.044 * P=0.509N P=0.759N P=0.472N P=0.217 |
|POLY 1.5 | P=0.040 * P=0.510N P=0.757 P=0.490N P=0.197 |
|POLY 6 | P=0.051 P=0.511N P=0.755N P=0.451N P=0.253 |
|LOGISTIC REGRESSION| P=0.040 * P=0.510N P=0.750N P=0.487N P=0.204 |
|COCH-ARM / FISHERS | P=0.039 * P=0.545N P=0.705 P=0.545N P=0.182 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous |
| Tumor (benign, malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 30
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor |
| (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/60 (5%) 3/50 (6%) 2/50 (4%) 5/50 (10%) 9/60 (15%) |
|POLY-3 ADJUSTED (b)| 7.9% 8.3% 5.2% 11.3% 21.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 1/16 (6%) 2/21 (10%) 4/31 (13%) 4/27 (15%) |
|FIRST INCIDENCE | 684 722 736 (T) 518 592 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.111 P=0.574N P=0.301N P=0.522N P=0.297 |
|POLY 3 | P=0.023 * P=0.646 P=0.495N P=0.446 P=0.090 |
|POLY 1.5 | P=0.018 * P=0.640 P=0.509N P=0.389 P=0.073 |
|POLY 6 | P=0.036 * P=0.644 P=0.486N P=0.511 P=0.125 |
|LOGISTIC REGRESSION| P=0.030 * P=0.665N P=0.428N P=0.453 P=0.106 |
|COCH-ARM / FISHERS | P=0.017 * P=0.570 P=0.586N P=0.262 P=0.063 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor |
| (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.3% 2.5% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 1/34 (3%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 738 (T) 738 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.551 (e) P=0.539 P=0.500 (e) |
|POLY 3 | P=0.537 (e) P=0.508 P=0.497 (e) |
|POLY 1.5 | P=0.535 (e) P=0.499 P=0.494 (e) |
|POLY 6 | P=0.541 (e) P=0.515 P=0.495 (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.539 P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.570 (e) P=0.455 P=0.455 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 31
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 2/50 (4%) 2/50 (4%) 2/50 (4%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 5.2% 5.4% 5.2% 4.5% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 1/21 (5%) 1/31 (3%) 0/27 (0%) |
|FIRST INCIDENCE | 603 505 666 614 614 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.217N P=0.680N P=0.649N P=0.551N P=0.447N |
|POLY 3 | P=0.306N P=0.681 P=0.694N P=0.642N P=0.466N |
|POLY 1.5 | P=0.332N P=0.677 P=0.686 P=0.676N P=0.483N |
|POLY 6 | P=0.267N P=0.679 P=0.689N P=0.604N P=0.438N |
|LOGISTIC REGRESSION| P=0.343N P=0.646 P=0.684 P=0.673 P=0.492N |
|COCH-ARM / FISHERS | P=0.353N P=0.619 P=0.619 P=0.619 P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 4.8% 2.3% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 1/33 (3%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 523 738 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.061N P=0.465N P=0.216N P=0.237N P=0.240N |
|POLY 3 | P=0.065N P=0.493N P=0.231N P=0.243N P=0.233N |
|POLY 1.5 | P=0.064N P=0.508N P=0.240N P=0.245N P=0.236N |
|POLY 6 | P=0.068N P=0.479N P=0.226N P=0.247N P=0.229N |
|LOGISTIC REGRESSION| P=0.063N P=0.535N P=0.277N P=0.275N P=0.237N |
|COCH-ARM / FISHERS | P=0.065N P=0.569N P=0.295N P=0.295N P=0.248N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 32
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, |
| or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 5/60 (8%) 3/50 (6%) 2/50 (4%) 4/50 (8%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 13.0% 8.0% 5.2% 9.1% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 1/16 (6%) 1/21 (5%) 3/31 (10%) 0/27 (0%) |
|FIRST INCIDENCE | 603 505 666 614 614 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.071N P=0.315N P=0.136N P=0.159N P=0.098N |
|POLY 3 | P=0.184N P=0.368N P=0.213N P=0.416N P=0.176N |
|POLY 1.5 | P=0.206N P=0.378N P=0.225N P=0.471N P=0.196N |
|POLY 6 | P=0.149N P=0.369N P=0.206N P=0.358N P=0.147N |
|LOGISTIC REGRESSION| P=0.188N P=0.408N P=0.208N P=0.420N P=0.185N |
|COCH-ARM / FISHERS | P=0.212N P=0.464N P=0.301N P=0.615N P=0.219N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, |
| or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/60 (5%) 1/50 (2%) 1/50 (2%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 7.2% 2.3% 2.3% 2.4% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/28 (7%) 1/33 (3%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 523 738 (T) 733 646 516 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.234N P=0.265N P=0.254N P=0.316N P=0.306N |
|POLY 3 | P=0.240N P=0.297N P=0.296N P=0.312N P=0.293N |
|POLY 1.5 | P=0.236N P=0.313N P=0.309N P=0.317N P=0.301N |
|POLY 6 | P=0.247N P=0.284N P=0.286N P=0.315N P=0.285N |
|LOGISTIC REGRESSION| P=0.224N P=0.319N P=0.318N P=0.342N P=0.304N |
|COCH-ARM / FISHERS | P=0.224N P=0.381N P=0.381N P=0.381N P=0.309N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 33
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 0/50 (0%) 2/50 (4%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 0.0% 4.6% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/16 (0%) 0/21 (0%) 2/31 (7%) 0/27 (0%) |
|FIRST INCIDENCE | 736 (T) --- --- 736 (T) 680 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.379N P=0.175N P=0.124N P=0.329N P=0.288N |
|POLY 3 | P=0.594N P=0.245N P=0.233N P=0.639N P=0.461N |
|POLY 1.5 | P=0.580 P=0.248N P=0.241N P=0.675N P=0.481N |
|POLY 6 | P=0.569N P=0.245N P=0.227N P=0.595N P=0.428N |
|LOGISTIC REGRESSION| P=0.470N (e) (e) P=0.329N P=0.405N |
|COCH-ARM / FISHERS | P=0.589N P=0.295N P=0.295N P=0.619 P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 2.3% 2.4% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) --- 733 646 516 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.469 P=0.467N P=0.713N P=0.748 P=0.758N |
|POLY 3 | P=0.455 P=0.493N P=0.751N P=0.760 P=0.750N |
|POLY 1.5 | P=0.457 P=0.503N P=0.760 P=0.755 P=0.756N |
|POLY 6 | P=0.453 P=0.483N P=0.743N P=0.760 P=0.744N |
|LOGISTIC REGRESSION| P=0.485 (e) P=0.731N P=0.754 P=0.762N |
|COCH-ARM / FISHERS | P=0.488 P=0.545N P=0.705 P=0.705 P=0.752N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 34
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 3/60 (5%) 1/50 (2%) 0/50 (0%) 2/50 (4%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 8.0% 2.7% 0.0% 4.6% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/16 (0%) 0/21 (0%) 2/31 (7%) 0/27 (0%) |
|FIRST INCIDENCE | 695 507 --- 736 (T) 680 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.137N P=0.259N P=0.061N P=0.158N P=0.135N |
|POLY 3 | P=0.286N P=0.312N P=0.115N P=0.435N P=0.267N |
|POLY 1.5 | P=0.299N P=0.319N P=0.122N P=0.477N P=0.286N |
|POLY 6 | P=0.264N P=0.310N P=0.111N P=0.388N P=0.236N |
|LOGISTIC REGRESSION| P=0.252N P=0.327N P=0.095N P=0.279N P=0.227N |
|COCH-ARM / FISHERS | P=0.292N P=0.381N P=0.159N P=0.586N P=0.309N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 2.3% 2.4% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) --- 733 646 516 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.469 P=0.467N P=0.713N P=0.748 P=0.758N |
|POLY 3 | P=0.455 P=0.493N P=0.751N P=0.760 P=0.750N |
|POLY 1.5 | P=0.457 P=0.503N P=0.760 P=0.755 P=0.756N |
|POLY 6 | P=0.453 P=0.483N P=0.743N P=0.760 P=0.744N |
|LOGISTIC REGRESSION| P=0.485 (e) P=0.731N P=0.754 P=0.762N |
|COCH-ARM / FISHERS | P=0.488 P=0.545N P=0.705 P=0.705 P=0.752N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 35
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 2/50 (4%) 1/50 (2%) 3/50 (6%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.5% 2.6% 6.8% 16.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 1/21 (5%) 2/31 (7%) 4/27 (15%) |
|FIRST INCIDENCE | --- 722 736 (T) 518 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.012 * P=0.290 P=0.612 P=0.249 P=0.061 |
|POLY 3 | P=0.003 ** P=0.227 P=0.503 P=0.152 P=0.011 * |
|POLY 1.5 | P=0.002 ** P=0.225 P=0.496 P=0.131 P=0.009 ** |
|POLY 6 | P=0.004 ** P=0.226 P=0.508 P=0.180 P=0.016 * |
|LOGISTIC REGRESSION| P=0.003 ** P=0.246 P=0.612 P=0.103 P=0.025 * |
|COCH-ARM / FISHERS | P=0.002 ** P=0.204 P=0.455 P=0.091 P=0.006 ** |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.5% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- 738 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.536 (e) (e) P=0.500 (e) |
|POLY 3 | P=0.502 (e) (e) P=0.497 (e) |
|POLY 1.5 | P=0.501 (e) (e) P=0.494 (e) |
|POLY 6 | P=0.510 (e) (e) P=0.495 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.549 (e) (e) P=0.455 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 36
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 0/50 (0%) 3/50 (6%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 5.3% 2.8% 0.0% 6.9% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/16 (0%) 0/21 (0%) 3/31 (10%) 0/27 (0%) |
|FIRST INCIDENCE | 736 (T) 723 --- 736 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.108N P=0.413N P=0.124N P=0.456N P=0.085N |
|POLY 3 | P=0.291N P=0.513N P=0.233N P=0.567 P=0.214N |
|POLY 1.5 | P=0.307N P=0.517N P=0.241N P=0.524 P=0.226N |
|POLY 6 | P=0.260N P=0.514N P=0.227N P=0.615 P=0.195N |
|LOGISTIC REGRESSION| P=0.139N P=0.468N (e) P=0.456N (e) |
|COCH-ARM / FISHERS | P=0.295N P=0.569N P=0.295N P=0.414 P=0.248N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.3% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 1/34 (3%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 738 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.694N (e) P=0.539 (e) (e) |
|POLY 3 | P=0.653N (e) P=0.508 (e) (e) |
|POLY 1.5 | P=0.653N (e) P=0.499 (e) (e) |
|POLY 6 | P=0.659N (e) P=0.515 (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.539 (e) (e) |
|COCH-ARM / FISHERS | P=0.668N (e) P=0.455 (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 37
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell |
| Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 3/50 (6%) 1/50 (2%) 5/50 (10%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 5.3% 8.3% 2.6% 11.3% 16.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 1/16 (6%) 1/21 (5%) 4/31 (13%) 4/27 (15%) |
|FIRST INCIDENCE | 736 (T) 722 736 (T) 518 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.149 P=0.608 P=0.306N P=0.617 P=0.353 |
|POLY 3 | P=0.036 * P=0.483 P=0.494N P=0.288 P=0.106 |
|POLY 1.5 | P=0.029 * P=0.478 P=0.506N P=0.242 P=0.092 |
|POLY 6 | P=0.051 P=0.483 P=0.485N P=0.346 P=0.137 |
|LOGISTIC REGRESSION| P=0.060 P=0.535 P=0.306N P=0.295 P=0.208 |
|COCH-ARM / FISHERS | P=0.028 * P=0.414 P=0.569N P=0.151 P=0.081 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell |
| Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.3% 2.5% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 1/34 (3%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 738 (T) 738 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.551 (e) P=0.539 P=0.500 (e) |
|POLY 3 | P=0.537 (e) P=0.508 P=0.497 (e) |
|POLY 1.5 | P=0.535 (e) P=0.499 P=0.494 (e) |
|POLY 6 | P=0.541 (e) P=0.515 P=0.495 (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.539 P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.570 (e) P=0.455 P=0.455 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 38
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 2/60 (3%) 3/50 (6%) 1/50 (2%) 5/50 (10%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 5.3% 8.3% 2.6% 11.3% 16.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 1/16 (6%) 1/21 (5%) 4/31 (13%) 4/27 (15%) |
|FIRST INCIDENCE | 736 (T) 722 736 (T) 518 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.149 P=0.608 P=0.306N P=0.617 P=0.353 |
|POLY 3 | P=0.036 * P=0.483 P=0.494N P=0.288 P=0.106 |
|POLY 1.5 | P=0.029 * P=0.478 P=0.506N P=0.242 P=0.092 |
|POLY 6 | P=0.051 P=0.483 P=0.485N P=0.346 P=0.137 |
|LOGISTIC REGRESSION| P=0.060 P=0.535 P=0.306N P=0.295 P=0.208 |
|COCH-ARM / FISHERS | P=0.028 * P=0.414 P=0.569N P=0.151 P=0.081 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.3% 2.5% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 1/34 (3%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 738 (T) 738 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.551 (e) P=0.539 P=0.500 (e) |
|POLY 3 | P=0.537 (e) P=0.508 P=0.497 (e) |
|POLY 1.5 | P=0.535 (e) P=0.499 P=0.494 (e) |
|POLY 6 | P=0.541 (e) P=0.515 P=0.495 (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.539 P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.570 (e) P=0.455 P=0.455 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 39
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- 661 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.050 (e) (e) (e) P=0.328 |
|POLY 3 | P=0.038 * (e) (e) (e) P=0.264 |
|POLY 1.5 | P=0.036 * (e) (e) (e) P=0.250 |
|POLY 6 | P=0.041 * (e) (e) (e) P=0.288 |
|LOGISTIC REGRESSION| P=0.034 * (e) (e) (e) P=0.258 |
|COCH-ARM / FISHERS | P=0.036 * (e) (e) (e) P=0.248 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 40
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 42/60 (70%) 47/50 (94%) 45/50 (90%) 46/50 (92%) 45/60 (75%) |
|POLY-3 ADJUSTED (b)| 93.4% 97.5% 95.8% 95.6% 96.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%) 27/27 (100%) |
|FIRST INCIDENCE | 561 410 521 518 502 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.465 P=0.181N P<0.001N** P=0.004N** |
|POLY 3 | P=0.470 P=0.256 P=0.475 P=0.498 P=0.452 |
|POLY 1.5 | P=0.401 P=0.069 P=0.200 P=0.157 P=0.325 |
|POLY 6 | P=0.571N P=0.587 P=0.782 P=0.782N P=0.754 |
|LOGISTIC REGRESSION| P=0.511N P=0.028 * P=0.241 P=0.621 P=0.410 |
|COCH-ARM / FISHERS | P=0.536 P<0.001 ** P=0.009 ** P=0.003 ** P=0.342 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 41
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/60 (8%) 8/50 (16%) 7/50 (14%) 6/50 (12%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 12.8% 21.5% 17.7% 13.6% 9.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 5/16 (31%) 3/21 (14%) 5/31 (16%) 3/27 (11%) |
|FIRST INCIDENCE | 535 450 593 544 675 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.043N* P=0.354 P=0.528 P=0.348N P=0.235N |
|POLY 3 | P=0.192N P=0.240 P=0.387 P=0.588 P=0.452N |
|POLY 1.5 | P=0.231N P=0.240 P=0.365 P=0.530 P=0.477N |
|POLY 6 | P=0.141N P=0.226 P=0.403 P=0.605N P=0.410N |
|LOGISTIC REGRESSION| P=0.200N P=0.241 P=0.357 P=0.533 P=0.440N |
|COCH-ARM / FISHERS | P=0.270N P=0.173 P=0.260 P=0.373 P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/60 (5%) 3/50 (6%) 1/50 (2%) 4/50 (8%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 7.2% 7.0% 2.3% 9.7% 16.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 3/33 (9%) 1/34 (3%) 2/28 (7%) 4/28 (14%) |
|FIRST INCIDENCE | 585 738 (T) 738 (T) 586 668 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.045 * P=0.593N P=0.263N P=0.507 P=0.186 |
|POLY 3 | P=0.058 P=0.653N P=0.296N P=0.492 P=0.168 |
|POLY 1.5 | P=0.059 P=0.653 P=0.309N P=0.483 P=0.161 |
|POLY 6 | P=0.056 P=0.637N P=0.288N P=0.485 P=0.176 |
|LOGISTIC REGRESSION| P=0.054 P=0.657N P=0.311N P=0.473 P=0.172 |
|COCH-ARM / FISHERS | P=0.067 P=0.570 P=0.381N P=0.399 P=0.161 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 42
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 2/50 (4%) 2/50 (4%) 2/50 (4%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.5% 5.2% 4.6% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 2/21 (10%) 2/31 (7%) 0/27 (0%) |
|FIRST INCIDENCE | --- 663 736 (T) 736 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.244N P=0.259 P=0.367 P=0.463 (e) |
|POLY 3 | P=0.400N P=0.229 P=0.240 P=0.273 (e) |
|POLY 1.5 | P=0.434N P=0.226 P=0.233 P=0.249 (e) |
|POLY 6 | P=0.348N P=0.229 P=0.246 P=0.301 (e) |
|LOGISTIC REGRESSION| P=0.340N P=0.228 P=0.367 P=0.463 (e) |
|COCH-ARM / FISHERS | P=0.469N P=0.204 P=0.204 P=0.204 (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 2/50 (4%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 4.8% 2.3% 4.7% 0.0% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/28 (7%) 1/33 (3%) 2/34 (6%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE | 738 (T) 738 (T) 738 (T) --- 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.317N P=0.442N P=0.624N P=0.238N P=0.500N |
|POLY 3 | P=0.296N P=0.487N P=0.679N P=0.239N P=0.488N |
|POLY 1.5 | P=0.293N P=0.505N P=0.693 P=0.243N P=0.496N |
|POLY 6 | P=0.305N P=0.471N P=0.667N P=0.242N P=0.481N |
|LOGISTIC REGRESSION| P=0.317N P=0.442N P=0.624N (e) P=0.500N |
|COCH-ARM / FISHERS | P=0.295N P=0.569N P=0.619 P=0.295N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 43
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/60 (8%) 10/50 (20%) 9/50 (18%) 8/50 (16%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 12.8% 26.7% 22.8% 18.1% 9.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 6/16 (38%) 5/21 (24%) 7/31 (23%) 3/27 (11%) |
|FIRST INCIDENCE | 535 450 593 544 675 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.023N* P=0.191 P=0.366 P=0.492N P=0.235N |
|POLY 3 | P=0.158N P=0.104 P=0.194 P=0.361 P=0.452N |
|POLY 1.5 | P=0.200N P=0.104 P=0.179 P=0.303 P=0.477N |
|POLY 6 | P=0.106N P=0.095 P=0.203 P=0.426 P=0.410N |
|LOGISTIC REGRESSION| P=0.155N P=0.108 P=0.187 P=0.331 P=0.440N |
|COCH-ARM / FISHERS | P=0.242N P=0.067 P=0.110 P=0.173 P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/60 (8%) 4/50 (8%) 3/50 (6%) 4/50 (8%) 8/60 (13%) |
|POLY-3 ADJUSTED (b)| 11.9% 9.3% 7.0% 9.7% 18.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/28 (11%) 4/33 (12%) 3/34 (9%) 2/28 (7%) 5/28 (18%) |
|FIRST INCIDENCE | 585 738 (T) 738 (T) 586 668 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.129 P=0.407N P=0.273N P=0.494N P=0.304 |
|POLY 3 | P=0.162 P=0.487N P=0.342N P=0.509N P=0.294 |
|POLY 1.5 | P=0.165 P=0.513N P=0.363N P=0.519N P=0.281 |
|POLY 6 | P=0.157 P=0.465N P=0.329N P=0.518N P=0.307 |
|LOGISTIC REGRESSION| P=0.155 P=0.467N P=0.329N P=0.520N P=0.302 |
|COCH-ARM / FISHERS | P=0.180 P=0.615N P=0.464N P=0.615N P=0.279 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 44
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 0.0% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- 688 --- 711 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.127 (e) P=0.515 (e) P=0.385 |
|POLY 3 | P=0.093 (e) P=0.504 (e) P=0.262 |
|POLY 1.5 | P=0.086 (e) P=0.497 (e) P=0.249 |
|POLY 6 | P=0.107 (e) P=0.511 (e) P=0.285 |
|LOGISTIC REGRESSION| P=0.092 (e) P=0.502 (e) P=0.312 |
|COCH-ARM / FISHERS | P=0.080 (e) P=0.455 (e) P=0.248 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 2.3% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 1/33 (3%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) 738 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.164N P=0.725N P=0.461N P=0.500N P=0.500N |
|POLY 3 | P=0.155N P=0.753N P=0.492N P=0.503N P=0.493N |
|POLY 1.5 | P=0.155N P=0.758 P=0.501N P=0.506N P=0.498N |
|POLY 6 | P=0.158N P=0.742N P=0.485N P=0.505N P=0.489N |
|LOGISTIC REGRESSION| P=0.164N P=0.725N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.166N P=0.705 P=0.545N P=0.545N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 45
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 1/50 (2%) 1/50 (2%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 2.6% 2.3% 7.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 1/31 (3%) 2/27 (7%) |
|FIRST INCIDENCE | --- 736 (T) 688 736 (T) 711 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.143 P=0.557 P=0.515 P=0.689 P=0.267 |
|POLY 3 | P=0.078 P=0.492 P=0.504 P=0.529 P=0.139 |
|POLY 1.5 | P=0.069 P=0.490 P=0.497 P=0.510 P=0.128 |
|POLY 6 | P=0.093 P=0.491 P=0.511 P=0.551 P=0.158 |
|LOGISTIC REGRESSION| P=0.098 P=0.557 P=0.502 P=0.689 P=0.197 |
|COCH-ARM / FISHERS | P=0.062 P=0.455 P=0.455 P=0.455 P=0.122 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 4.8% 2.3% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/28 (7%) 1/33 (3%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) 738 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.061N P=0.442N P=0.196N P=0.238N P=0.238N |
|POLY 3 | P=0.065N P=0.487N P=0.228N P=0.239N P=0.229N |
|POLY 1.5 | P=0.064N P=0.505N P=0.238N P=0.243N P=0.234N |
|POLY 6 | P=0.068N P=0.471N P=0.221N P=0.242N P=0.224N |
|LOGISTIC REGRESSION| P=0.061N P=0.442N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.065N P=0.569N P=0.295N P=0.295N P=0.248N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 46
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 6/60 (10%) 6/50 (12%) 3/50 (6%) 4/50 (8%) 6/60 (10%) |
|POLY-3 ADJUSTED (b)| 14.5% 14.0% 7.0% 9.7% 13.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/28 (21%) 4/33 (12%) 3/34 (9%) 3/28 (11%) 4/28 (14%) |
|FIRST INCIDENCE | 738 (T) 715 738 (T) 592 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.550 P=0.498N P=0.151N P=0.364N P=0.611N |
|POLY 3 | P=0.474N P=0.594N P=0.221N P=0.369N P=0.588N |
|POLY 1.5 | P=0.476N P=0.613 P=0.243N P=0.384N P=0.608N |
|POLY 6 | P=0.477N P=0.557N P=0.204N P=0.369N P=0.566N |
|LOGISTIC REGRESSION| P=0.498N P=0.508N P=0.151N P=0.388N P=0.581N |
|COCH-ARM / FISHERS | P=0.474N P=0.486 P=0.344N P=0.491N P=0.619N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 47
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 6/60 (10%) 6/50 (12%) 4/50 (8%) 5/50 (10%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 14.5% 14.0% 9.3% 12.1% 16.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/28 (21%) 4/33 (12%) 4/34 (12%) 4/28 (14%) 4/28 (14%) |
|FIRST INCIDENCE | 738 (T) 715 738 (T) 592 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.384 P=0.498N P=0.249N P=0.497N P=0.518 |
|POLY 3 | P=0.457 P=0.594N P=0.343N P=0.501N P=0.541 |
|POLY 1.5 | P=0.453 P=0.613 P=0.371N P=0.517N P=0.517 |
|POLY 6 | P=0.459 P=0.557N P=0.321N P=0.503N P=0.569 |
|LOGISTIC REGRESSION| P=0.438 P=0.508N P=0.249N P=0.525N P=0.542 |
|COCH-ARM / FISHERS | P=0.465 P=0.486 P=0.491N P=0.622 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 48
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 4.6% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- 698 708 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.596 (e) P=0.524 P=0.424 (e) |
|POLY 3 | P=0.461 (e) P=0.504 P=0.273 (e) |
|POLY 1.5 | P=0.435 (e) P=0.497 P=0.250 (e) |
|POLY 6 | P=0.517 (e) P=0.510 P=0.303 (e) |
|LOGISTIC REGRESSION| P=0.520 (e) P=0.507 P=0.320 (e) |
|COCH-ARM / FISHERS | P=0.457 (e) P=0.455 P=0.204 (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 49
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or |
| Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 25/60 (42%) 26/50 (52%) 26/50 (52%) 23/50 (46%) 15/60 (25%) |
|POLY-3 ADJUSTED (b)| 58.6% 61.5% 57.8% 48.9% 34.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/12 (42%) 8/16 (50%) 8/21 (38%) 11/31 (36%) 8/27 (30%) |
|FIRST INCIDENCE | 561 507 482 518 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.544N P=0.351N P=0.013N* P<0.001N** |
|POLY 3 | P=0.004N** P=0.476 P=0.560N P=0.238N P=0.017N* |
|POLY 1.5 | P=0.007N** P=0.430 P=0.513 P=0.358N P=0.023N* |
|POLY 6 | P=0.002N** P=0.494 P=0.488N P=0.155N P=0.012N* |
|LOGISTIC REGRESSION| P=0.005N** P=0.398 P=0.439 P=0.316N P=0.013N* |
|COCH-ARM / FISHERS | P=0.013N* P=0.187 P=0.187 P=0.396 P=0.040N* |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or |
| Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 15/60 (25%) 15/50 (30%) 15/50 (30%) 18/50 (36%) 11/60 (18%) |
|POLY-3 ADJUSTED (b)| 33.8% 32.6% 32.0% 39.7% 24.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/28 (18%) 6/33 (18%) 7/34 (21%) 8/28 (29%) 2/28 (7%) |
|FIRST INCIDENCE | 475 392 451 459 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.314N P=0.436N P=0.442N P=0.345 P=0.231N |
|POLY 3 | P=0.277N P=0.542N P=0.516N P=0.356 P=0.222N |
|POLY 1.5 | P=0.278N P=0.577 P=0.577N P=0.318 P=0.239N |
|POLY 6 | P=0.279N P=0.501N P=0.476N P=0.364 P=0.209N |
|LOGISTIC REGRESSION| P=0.245N P=0.468 P=0.450 P=0.225 P=0.238N |
|COCH-ARM / FISHERS | P=0.236N P=0.354 P=0.354 P=0.148 P=0.253N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 50
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 4.9% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- 613 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.394 (e) (e) P=0.237 (e) |
|POLY 3 | P=0.356 (e) (e) P=0.236 (e) |
|POLY 1.5 | P=0.356 (e) (e) P=0.231 (e) |
|POLY 6 | P=0.361 (e) (e) P=0.235 (e) |
|LOGISTIC REGRESSION| P=0.408 (e) (e) P=0.219 (e) |
|COCH-ARM / FISHERS | P=0.413 (e) (e) P=0.204 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 51
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 9/60 (15%) |
|POLY-3 ADJUSTED (b)| 2.6% 0.0% 5.1% 0.0% 20.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 4/27 (15%) |
|FIRST INCIDENCE | 617 --- 593 --- 502 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.517N P=0.490 P=0.470N P=0.049 * |
|POLY 3 | P<0.001 ** P=0.510N P=0.509 P=0.473N P=0.015 * |
|POLY 1.5 | P<0.001 ** P=0.511N P=0.496 P=0.491N P=0.011 * |
|POLY 6 | P<0.001 ** P=0.513N P=0.521 P=0.453N P=0.024 * |
|LOGISTIC REGRESSION| P<0.001 ** P=0.533N P=0.435 P=0.551N P=0.013 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.545N P=0.431 P=0.545N P=0.008 ** |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 52
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 48/60 (80%) 50/50 (100%) 48/50 (96%) 48/50 (96%) 47/60 (78%) |
|POLY-3 ADJUSTED (b)| 98.9% 100.0% 99.2% 98.7% 98.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%) 27/27 (100%) |
|FIRST INCIDENCE | 396 410 443 518 502 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.499N P=0.113N P<0.001N** P<0.001N** |
|POLY 3 | P=0.457N P=0.963 P=0.984 P=0.911N P=0.991N |
|POLY 1.5 | P=0.253N P=0.062 P=0.423 P=0.451 P=0.757N |
|POLY 6 | P=0.742N P=1.000 P=1.000N P=0.973N P=1.000N |
|LOGISTIC REGRESSION| P=0.096N P=0.317 P=0.552N P=0.463N P=0.397N |
|COCH-ARM / FISHERS | P=0.147N P<0.001 ** P=0.011 * P=0.011 * P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 37/60 (62%) 37/50 (74%) 27/50 (54%) 30/50 (60%) 35/60 (58%) |
|POLY-3 ADJUSTED (b)| 80.0% 81.7% 58.0% 67.5% 76.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 23/28 (82%) 28/33 (85%) 19/34 (56%) 20/28 (71%) 22/28 (79%) |
|FIRST INCIDENCE | 507 522 417 417 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.425N P=0.224N P=0.011N* P=0.168N P=0.379N |
|POLY 3 | P=0.249N P=0.522 P=0.015N* P=0.116N P=0.442N |
|POLY 1.5 | P=0.235N P=0.437 P=0.028N* P=0.140N P=0.444N |
|POLY 6 | P=0.291N P=0.557 P=0.011N* P=0.152N P=0.465N |
|LOGISTIC REGRESSION| P=0.218N P=0.571N P=0.029N* P=0.105N P=0.322N |
|COCH-ARM / FISHERS | P=0.203N P=0.121 P=0.268N P=0.507N P=0.426N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 53
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 32/60 (53%) 37/50 (74%) 36/50 (72%) 32/50 (64%) 30/60 (50%) |
|POLY-3 ADJUSTED (b)| 71.0% 81.3% 75.3% 67.3% 62.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 7/12 (58%) 11/16 (69%) 12/21 (57%) 18/31 (58%) 14/27 (52%) |
|FIRST INCIDENCE | 396 450 360 518 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.392 P=0.429N P=0.007N** P=0.020N* |
|POLY 3 | P=0.052N P=0.166 P=0.405 P=0.435N P=0.245N |
|POLY 1.5 | P=0.080N P=0.122 P=0.270 P=0.577N P=0.305N |
|POLY 6 | P=0.031N* P=0.206 P=0.526 P=0.323N P=0.184N |
|LOGISTIC REGRESSION| P=0.102N P=0.100 P=0.158 P=0.489N P=0.329N |
|COCH-ARM / FISHERS | P=0.145N P=0.020 * P=0.035 * P=0.175 P=0.428N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 20/60 (33%) 18/50 (36%) 23/50 (46%) 24/50 (48%) 16/60 (27%) |
|POLY-3 ADJUSTED (b)| 45.1% 39.1% 48.6% 51.4% 34.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 10/28 (36%) 9/33 (27%) 12/34 (35%) 10/28 (36%) 3/28 (11%) |
|FIRST INCIDENCE | 475 392 451 459 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.410N P=0.268N P=0.562 P=0.296 P=0.251N |
|POLY 3 | P=0.303N P=0.360N P=0.448 P=0.346 P=0.197N |
|POLY 1.5 | P=0.331N P=0.429N P=0.360 P=0.276 P=0.233N |
|POLY 6 | P=0.271N P=0.313N P=0.516 P=0.392 P=0.162N |
|LOGISTIC REGRESSION| P=0.321N P=0.495N P=0.276 P=0.180 P=0.252N |
|COCH-ARM / FISHERS | P=0.301N P=0.463 P=0.123 P=0.086 P=0.275N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 54
Statistical Analysis of Primary Tumors in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 50/60 (83%) 50/50 (100%) 50/50 (100%) 48/50 (96%) 50/60 (83%) |
|POLY-3 ADJUSTED (b)| 99.7% 100.0% 100.0% 98.7% 99.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%) 27/27 (100%) |
|FIRST INCIDENCE | 396 410 360 518 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.405N P=0.120N P<0.001N** P=0.003N** |
|POLY 3 | P=0.480N P=1.000 P=1.000 P=0.804N P=1.000N |
|POLY 1.5 | P=0.235N P=0.276 P=0.276 P=0.792 P=0.875N |
|POLY 6 | P=0.794N P=1.000 P=1.000 P=0.960N P=1.000N |
|LOGISTIC REGRESSION| P=0.565N (e) (e) P=0.219N P=0.608 |
|COCH-ARM / FISHERS | P=0.224N P=0.002 ** P=0.002 ** P=0.032 * P=0.596N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # # |
|----------- | |
|OVERALL (a) | 45/60 (75%) 43/50 (86%) 42/50 (84%) 43/50 (86%) 42/60 (70%) |
|POLY-3 ADJUSTED (b)| 93.9% 89.9% 85.4% 87.4% 86.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 26/28 (93%) 29/33 (88%) 27/34 (79%) 22/28 (79%) 22/28 (79%) |
|FIRST INCIDENCE | 475 392 417 417 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.488N P=0.131N P=0.100N P=0.469N P=0.315N |
|POLY 3 | P=0.161N P=0.361N P=0.143N P=0.218N P=0.171N |
|POLY 1.5 | P=0.190N P=0.535N P=0.289N P=0.399N P=0.231N |
|POLY 6 | P=0.140N P=0.308N P=0.103N P=0.165N P=0.140N |
|LOGISTIC REGRESSION| P=0.235N P=0.509N P=0.331N P=0.490N P=0.245N |
|COCH-ARM / FISHERS | P=0.182N P=0.115 P=0.179 P=0.115 P=0.342N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).