TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
Core Study
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 PPM
Include 002 0 PPM
Include 003 200 PPM
Include 004 200 PPM
Include 005 400 PPM
Include 006 400 PPM
Include 007 600 PPM
Include 008 600 PPM
Page 1
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|
DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|
| 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 2 2 2 1 2 2 2 1 1 1 |
Mixed Cell Focus | X X X X |
Pigmentation, Hemosiderin | 2 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 1 1 1 2 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 1 2 2 1 |
Hepatocyte, Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | |
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | 2 |
Epithelium, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|
DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|
| 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atrophy | 3 |
Degeneration, Fatty | 3 2 1 1 2 |
Hyperplasia | 2 3 2 1 1 |
Hypertrophy | 1 |
Pigmentation | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Pars Distalis, Cyst | 2 2 3 2 2 1 2 2 2 1 1 1 1 2 2|
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 3 2 2 2 2 1 3 1 2 2|
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 2 2 3 3 2 |
Inflammation, Chronic Active | 1 3 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3|
Bilateral, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + + |
Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 4 4 4 3 3 4|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|
DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|
| 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemosiderin | 1 1 2 1 1 1 1 2 2 1 1 2 2 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 1 1 |
Necrosis | 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia, Cystic | 1 3 3 4 2 2 3 2 2 2 2 2 3 4 2 2 2 1 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 3 2 3 3 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X X |
Inflammation, Chronic Active | 1 2 2 2 3 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 1 |
Respiratory Epithelium, Hyperplasia | 2 3 3 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5|
DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7|
| 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 1 1 1 2 2 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 2 2 |
Renal Tubule, Pigmentation | 1 1 3 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| |
| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X | 41 |
Clear Cell Focus | X X X X | 11 |
Eosinophilic Focus | X | 2 |
Hepatodiaphragmatic Nodule | X X X X X X | 9 |
Inflammation, Chronic | 1 2 1 1 1 2 1 1 1 1 1 1 1 3 1 1 1| 31 1.3|
Mixed Cell Focus | X X X | 7 |
Pigmentation, Hemosiderin | | 1 2.0|
Thrombosis | 2 | 2 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 | 24 1.2|
Hepatocyte, Vacuolization Cytoplasmic| 1 3 | 7 1.9|
Hepatocyte, Centrilobular, Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Accessory Spleen | X | 1 |
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Fat, Necrosis | 4 | 3 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 2 | 10 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 2 | 3 2.3|
Epithelium, Ulcer | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| |
| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 1 2 2 1 1 1 2 1 1| 27 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Atrophy | | 1 3.0|
Degeneration, Fatty | 1 1 2 1 | 9 1.6|
Hyperplasia | 1 2 | 7 1.7|
Hypertrophy | | 1 1.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + M + + + + + + + + + +| 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
Pars Distalis, Cyst | 2 3 2 1 2 1 1 1 2 2 2 2 2 3 3 2 2 2 2 2| 35 1.9|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 | 24 2.0|
Pars Intermedia, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 1| 16 1.1|
Follicular Cell, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 | 10 2.6|
Inflammation, Chronic Active | 1 1| 4 1.5|
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 3 3.0|
Bilateral, Cyst | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| |
| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | | 2 |
Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 | 11 3.7|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 35 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 1 2 2 1 2 1 1 1 1 2 2 2 1 1| 30 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 3 1 1 1 | 9 1.3|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 2 4.0|
Hyperplasia, Cystic | 2 2 2 2 4 2 1 2 3 2 2 2 2 1 2 2 2 3 3 3 2 1 2| 43 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 | 6 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 | 12 1.0|
Alveolar Epithelium, Hyperplasia | | 5 2.4|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| |
DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| |
| 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 41 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X X | 6 |
Inflammation, Chronic Active | 2 1 3 2 1 2 2 | 13 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 2 1 1 1 2 | 9 1.8|
Respiratory Epithelium, Hyperplasia | 2 3 3 2 2 | 10 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Atrophy | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Nephropathy, Chronic | 1 1 2 2 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1| 44 1.3|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1| 48 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 2| 9| 3| 3| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 3|
| 6| 9| 0| 1| 8| 8| 4| 8| 2| 8| 0| 8| 9| 8| 9| 0| 8| 9| 0| 5| 0| 9| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 2 1 1 1 1 2 1 2 2 2 2 2 1 1 2 2 1|
Mixed Cell Focus | X X X|
Pigmentation, Bile | 2 |
Thrombosis | 4 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Mesentery | |
Accessory Spleen | |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 1 1 1 2|
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 1 1 1 2 1 1 1 2 1 1 1 1 1 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atrophy | |
Degeneration, Cystic | 3 |
Degeneration, Fatty | 1 3 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 2| 9| 3| 3| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 3|
| 6| 9| 0| 1| 8| 8| 4| 8| 2| 8| 0| 8| 9| 8| 9| 0| 8| 9| 0| 5| 0| 9| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 1 1 2 1 |
Hypertrophy | 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Cyst | 2 2 4 3 2 2 2 3 2 3 1 2 |
Pars Distalis, Hyperplasia | 2 2 1 2 2 4 2 3 3 |
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 2 4 |
Inflammation, Chronic Active | 2 2 1 1 1 |
Bilateral, Hyperplasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia | 4 4 4 3 3 3 4 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 2 1 2 1 2 1 2 2 1 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + M + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 2| 9| 3| 3| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 3|
| 6| 9| 0| 1| 8| 8| 4| 8| 2| 8| 0| 8| 9| 8| 9| 0| 8| 9| 0| 5| 0| 9| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 |
Hyperplasia, Cystic | 2 2 4 4 2 2 4 2 2 2 2 1 2 2 3 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
Mandible, Cyst | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic Active | 1 2 1 2 1 1 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 1 1 |
Respiratory Epithelium, Hyperplasia | 2 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 |
Lens, Fibrosis | 3 |
Lens, Synechia | 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Zymbal's Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 2| 9| 3| 3| 3| 4| 3| 3| 2| 3| 4| 3| 4| 3| 3|
| 6| 9| 0| 1| 8| 8| 4| 8| 2| 8| 0| 8| 9| 8| 9| 0| 8| 9| 0| 5| 0| 9| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic | 1 1 1 2 1 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Papilla, Necrosis | |
Pelvis, Inflammation, Suppurative | |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| |
DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| |
| 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | 42 |
Clear Cell Focus | X X X X X X | 10 |
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X X | 4 |
Inflammation, Chronic | 2 2 1 1 1 1 2 1 1 2 1 2 2 1 1 2 1 | 36 1.5|
Mixed Cell Focus | X X X X | 7 |
Pigmentation, Bile | 1 | 2 1.5|
Thrombosis | | 1 4.0|
Bile Duct, Cyst | 3 | 1 3.0|
Bile Duct, Hyperplasia | 1 2 2 1 1 2 1 1 2| 18 1.3|
Hepatocyte, Necrosis | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Accessory Spleen | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 1 1 1 2 1 1 1 | 14 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 2 1 2 2 2 1 1 2 1 1 1 2 2 | 31 1.4|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| |
DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| |
| 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 1 | 2 1.5|
Atrophy | 2 | 1 2.0|
Degeneration, Cystic | 2 2 2 | 4 2.3|
Degeneration, Fatty | 1 1 2 1 1 | 11 1.4|
Hyperplasia | 1 1 1 2 2 1 | 12 1.3|
Hypertrophy | 2 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 1 1| 7 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + + + + + + + + + + + + M + + M| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2| 1 2.0|
Pars Distalis, Cyst | 2 2 2 2 2 2 2 2 3 4 3 3 1 2 4 3 | 28 2.4|
Pars Distalis, Hyperplasia | 2 2 2 1 2 3 3 2 2 2 3 4 | 21 2.3|
Pars Intermedia, Cyst | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 1 2 1 1 2 1| 23 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 1 2 3 2 2 | 11 2.5|
Inflammation, Chronic Active | 2 2 2 1 2 2 | 11 1.6|
Bilateral, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 2 | 6 3.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 4 4 | 2 4.0|
Endometrium, Hyperplasia, Cystic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia | 3 3 4 4 4 4 | 13 3.6|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 27 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| |
DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| |
| 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 1 1 1 1 2 1 1 | 22 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 | 12 1.1|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + M + + + + + + + + + M| 44 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.5|
Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 1 2 2 2 4 2 | 44 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 2.0|
Mandible, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | 2 | 1 2.0|
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 12 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X | 2 |
Inflammation, Chronic Active | 2 1 1 | 13 1.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 1 | 6 1.5|
Respiratory Epithelium, Hyperplasia | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 4| |
DAY ON TEST | 3| 4| 5| 3| 0| 4| 4| 3| 3| 3| 1| 3| 3| 4| 1| 4| 3| 3| 3| 4| 3| 9| 3| 4| 3| |
| 9| 0| 0| 7| 1| 0| 0| 9| 9| 9| 5| 5| 8| 0| 5| 0| 8| 9| 8| 0| 8| 2| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
200 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | 4 | 2 4.0|
Lens, Fibrosis | | 1 3.0|
Lens, Synechia | 4 | 2 4.0|
Retina, Atrophy | 4 | 3 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1| 46 1.1|
Papilla, Necrosis | 4 | 1 4.0|
Pelvis, Inflammation, Suppurative | 3 | 1 3.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 2 2| 48 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4|
| 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Eosinophilic Focus | X |
Fibrosis | 1 |
Hepatodiaphragmatic Nodule | X X X X|
Inflammation, Chronic | 1 1 1 1 1 3 3 1 1 1 1 1 1 1 3 1 |
Mixed Cell Focus | |
Pigmentation, Bile | 2 |
Bile Duct, Hyperplasia | 1 1 1 3 2 2 1 2 |
Hepatocyte, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 |
Hepatocyte, Centrilobular, | |
Degeneration | 2 |
Hepatocyte, Centrilobular, Necrosis | 2 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Acinus, Atrophy | 1 4 1 1 |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 |
Epithelium, Hyperplasia | 3 2 |
Epithelium, Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 2 2 2 2 2 1 1 1 1 2 2 2 2 2 2|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4|
| 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Degeneration, Fatty | 4 1 2 1 1 2 1 1|
Hyperplasia | 1 2 2 1 1 1 1 3 1 1 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + + + M + M M + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 2 3 2 2 2 2 1 2 3 2 2 2 2 2 2|
Pars Distalis, Hyperplasia | 4 2 4 2 3 2 2 2 2 2 1|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 2 1 2 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 3 1 2 3 4 2|
Inflammation, Chronic Active | 1 2 3 |
Bilateral, Hyperplasia | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 3 3 4 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 4 |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 2 1 1 1 1 2 1 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4|
| 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 1 2 1 2 2 1 2 2 3 2 3 2 2 3 2 2 3 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Epidermis, Hyperplasia | 2 |
Epidermis, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 |
Alveolar Epithelium, Hyperplasia | 2 1 1 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X|
Inflammation, Chronic Active | 1 1 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 2 1 |
Respiratory Epithelium, Hyperplasia | 2|
Vein, Turbinate, Septum, Thrombosis | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 3 2 1 1 1 1 1 1 1 1 1 2 2 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7|
DAY ON TEST | 5| 0| 9| 3| 7| 3| 9| 3| 3| 3| 4| 1| 3| 3| 3| 3| 3| 2| 3| 3| 9| 2| 4| 4| 4|
| 1| 0| 0| 8| 0| 8| 2| 9| 9| 3| 0| 4| 8| 8| 9| 9| 9| 5| 8| 8| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
400 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| |
| 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X| 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 44 |
Clear Cell Focus | X X X X X| 8 |
Eosinophilic Focus | | 1 |
Fibrosis | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X | 7 |
Inflammation, Chronic | 1 1 2 2 1 2 2 2 3 1 1 2 1 2 1 1 2| 33 1.5|
Mixed Cell Focus | X X X X X | 5 |
Pigmentation, Bile | | 1 2.0|
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 2 2 1| 22 1.4|
Hepatocyte, Necrosis | 1 | 2 1.5|
Hepatocyte, Vacuolization Cytoplasmic| | 1 1.0|
Hepatocyte, Centrilobular, | | |
Degeneration | | 1 2.0|
Hepatocyte, Centrilobular, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Acinus, Atrophy | 2 1 1 2 1 1 2 1 2 1 | 14 1.5|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 3 3.0|
Epithelium, Hyperplasia | 2 | 3 2.3|
Epithelium, Ulcer | 4 | 3 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| |
| 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 2 2 1 1 1 2 1 2 1 1 2 1 1 2 2| 36 1.5|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 1 | 3 1.3|
Degeneration, Fatty | 1 1 1 1 2 2 1 2 1| 17 1.5|
Hyperplasia | 1 1 1 1 1 1 1 1 1 2 2 2| 23 1.3|
Hypertrophy | 1 2 2 1 2 2 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + M + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 1 3 3 1 2 1 2 2 1 2 2 2 3 2 2 2 2 2| 34 2.0|
Pars Distalis, Hyperplasia | 2 2 2 3 3 2 1 2 3 3 2 2 3 3 3| 26 2.4|
Pars Intermedia, Hyperplasia | 3| 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 2 2 1 2 1 1 1 2 | 27 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 4 2 2 2 2 | 13 2.4|
Inflammation, Chronic Active | 1 | 4 1.8|
Bilateral, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4 3 | 4 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| |
| 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 3 3 4 4 3 3 2 | 17 3.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 26 |
Mediastinal, Hemorrhage | | 1 4.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 2 2 1 2 2 1 2 2 2| 21 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Cyst | 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2 2 2| 45 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
Epidermis, Hyperplasia | 3 | 2 2.5|
Epidermis, Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 3 2 3 3 | 4 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | 17 1.1|
Alveolar Epithelium, Hyperplasia | | 5 1.4|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | | 1 |
Inflammation, Chronic Active | 1 2 1 1 | 7 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 1| 4| 4| 3| 6| 4| 3| 4| 8| 3| 4| 3| 4| 3| 4| 3| 4| 3| 4| 3| 3| 3| 3| 4| |
| 9| 7| 0| 7| 9| 3| 0| 8| 0| 4| 9| 0| 8| 0| 9| 0| 8| 0| 8| 4| 8| 9| 5| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
400 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 2 1 3| 10 1.5|
Respiratory Epithelium, Hyperplasia | 1 | 2 1.5|
Vein, Turbinate, Septum, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 3 | 2 3.0|
Retina, Atrophy | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 1 1 1 1 2 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.1|
Renal Tubule, Pigmentation | 1 1 1 1 1 2 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7|
DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4|
| 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 2 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 2 2|
Hepatocyte, Degeneration, Cystic | |
Hepatocyte, Vacuolization Cytoplasmic| 1 |
Hepatocyte, Centrilobular, | |
Degeneration | |
Kupffer Cell, Hypertrophy | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | |
Epithelium, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7|
DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4|
| 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2 1 2 |
Fibrosis | 2 |
Hyperplasia | 2 2 1 1 1 |
Hypertrophy | 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
Pars Distalis, Cyst | 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 1 3 2|
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 2 |
Inflammation, Chronic Active | 3 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2|
Hyperplasia | 4 4 4 4 3 4 4 4 4 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Hematopoietic Cell Proliferation | 1 1 3 2 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7|
DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4|
| 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 1 1 2 1 2 4 1 1 2 2 2 2 1 2 2 2 2 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 3 1|
Respiratory Epithelium, Hyperplasia | 2 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 |
Hydronephrosis | 4 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 4| 6| 5| 7| 7| 7| 6| 6| 7| 5| 4| 7| 5| 7|
DAY ON TEST | 2| 3| 8| 4| 9| 3| 4| 4| 4| 3| 0| 5| 4| 8| 3| 3| 3| 0| 3| 3| 7| 1| 3| 8| 4|
| 2| 8| 6| 4| 2| 9| 0| 0| 0| 4| 4| 9| 6| 8| 8| 8| 9| 5| 2| 8| 1| 7| 9| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Pigmentation | 1 2 3 1 2 1 1 1 1 1 2 1 1 2 1 1 1 2 1 2 2 1 1 3 2|
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| |
| 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 35 |
Clear Cell Focus | X X| 3 |
Eosinophilic Focus | X X | 3 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Chronic | 2 1 1 3 1 1 1 1 1 1 1 1 2| 27 1.2|
Mixed Cell Focus | X | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 1 1 1 1 1 2 | 19 1.5|
Hepatocyte, Degeneration, Cystic | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 | 3 1.0|
Hepatocyte, Centrilobular, | | |
Degeneration | 1 | 1 1.0|
Kupffer Cell, Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 2 2 1 3 2 2 | 9 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Epithelium, Hyperplasia | 2 2 1 | 3 1.7|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| |
| 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 2 1 2 2 1 1 1 1 2 1 1 2 2 1 2 1 1 1| 35 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 1 2 1 2 1 1 1 1 | 15 1.5|
Fibrosis | | 1 2.0|
Hyperplasia | 2 1 2 2 2 1 2 | 12 1.6|
Hypertrophy | 2 1 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 7 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 4.0|
Pars Distalis, Cyst | 2 2 3 2 1 3 1 2 1 2 2 2 2 2 2 1 2 2| 32 2.0|
Pars Distalis, Hyperplasia | 2 2 2 4 2 2 3 3 1 2 2 2 1 2 | 27 2.0|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 2 2 1 2 2 1 1 1 2 | 20 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 3 3 2 2 | 11 2.1|
Inflammation, Chronic Active | 2 2 1 2 | 5 2.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 4 2 3 3 | 8 3.1|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 4 | 2 3.5|
Endometrium, Hyperplasia, Cystic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| |
| 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia | 4 4 4 4 4 4 3 4 4 3 4 | 21 3.9|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 28 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 2 2 2 2 1 2 1 2 1 1 1 1 1| 24 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Hematopoietic Cell Proliferation | 3 3 1 3 1| 10 1.9|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + M + + + + + +| 47 |
Ectopic Parathyroid Gland | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2| 42 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 15 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 1.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 46 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 2 | 6 1.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 6 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 0| 4| 8| 7| 3| 4| 3| 4| 3| 3| 9| 3| 4| 1| 4| 3| 3| 3| 4| 4| 3| 9| 3| 4| |
| 9| 5| 0| 4| 2| 8| 2| 8| 0| 4| 9| 0| 8| 0| 3| 0| 9| 9| 9| 0| 0| 8| 2| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
600 PPM | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Hyperplasia | 2 | 4 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 4.0|
Retina, Atrophy | | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 2.0|
Hydronephrosis | | 1 4.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0|
Renal Tubule, Pigmentation | 1 2 1 1 2 2 1 2 1 1 1 2 1 1 2 1 1 1 1 1 1 1 2 1 1| 50 1.4|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|
| 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X|
Clear Cell Focus | X X|
Eosinophilic Focus | X |
Inflammation, Chronic | 2 1 1 1 2 1 1 1 1 1 1 1 1|
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 1 3 1 1 3 2 1 2 1 2 3 1 3 1 2 2 1 3 3 1 2 1 2 1|
Hepatocyte, Degeneration, Cystic | 2 1 3 2 2 2 1 1 3 |
Hepatocyte, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 |
Hepatocyte, Centrilobular, | |
Degeneration | 1 |
Hepatocyte, Centrilobular, Necrosis | 4 |
Kupffer Cell, Hypertrophy | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 2 1 1 1 1 1 3 |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 3 3 2 |
Epithelium, Hyperplasia | 2 3 2 2 2 |
Epithelium, Ulcer | 4 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 2 |
Epithelium, Erosion | 2 |
Epithelium, Ulcer | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|
| 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 3 |
Pulmonary Artery, Thrombosis | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Atrium, Thrombosis | 4 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Degeneration, Cystic | 2 |
Degeneration, Fatty | 1 1 2 1 1 1 1 1 2 1 3 1 1 |
Hyperplasia | 1 2 1 2 2 2 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 3 3 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2 3 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | 3 2 2 1 2 |
Pars Distalis, Hyperplasia | 2 3 3 2 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 1 2 2 2 |
Follicular Cell, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Inflammation, Chronic Active | 4 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 3|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2|
Duct, Cyst | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 4 1 2 2 1 2 2 2 1 4 1 2 3 2 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|
| 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Arteriole, Inflammation, Chronic | |
Germinal Epithelium, Atrophy | 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 3 4 4 3 4 4 4 4 4 4 3 |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | 1 1 1 1 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 4 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 1 2 3 1 2 2 2 3 2 3 2 1 2 2 2 2 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | 3 |
Sebaceous Gland, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic Active | 1 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3|
| 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | X X X X X X X X X X|
Inflammation, Chronic Active | 2 3 2 2 2 2 2 1 2 3 4 3|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2 |
Respiratory Epithelium, Hyperplasia | 3 2 2 2 2 2 1 2 3 3 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy, Chronic | 2 2 2 4 2 3 1 2 2 4 3 3 3 3 2 3 4 4 2 4 3 2 4 2 3|
Renal Tubule, Hyperplasia | 3 |
Renal Tubule, Pigmentation | 1 1 3 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| |
DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| |
| 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 2.0|
Basophilic Focus | X X X X X X X X | 17 |
Clear Cell Focus | X X X X | 6 |
Eosinophilic Focus | X | 2 |
Inflammation, Chronic | 1 2 1 1 1 1 1 2 1 | 22 1.2|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | 2 2 3 3 2 2 1 3 2 2 2 1 2 2 2 3 3 2 3 1 1 1 3 2 2| 49 1.9|
Hepatocyte, Degeneration, Cystic | 2 1 2 2 1 1 2 | 16 1.8|
Hepatocyte, Necrosis | 2 2 | 3 1.7|
Hepatocyte, Vacuolization Cytoplasmic| 1 3 2 1 2 | 10 1.4|
Hepatocyte, Centrilobular, | | |
Degeneration | 3 | 2 2.0|
Hepatocyte, Centrilobular, Necrosis | 2 | 2 3.0|
Kupffer Cell, Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + +| 15 |
Fat, Necrosis | 4 4 4 4 4 4 4 4 4| 12 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | 1 2 1 1 1 | 12 1.3|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 2 1 3 3 | 10 2.6|
Epithelium, Hyperplasia | 2 1 3 | 8 2.1|
Epithelium, Ulcer | 4 4 1 4 4 | 8 3.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| |
DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| |
| 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 2.0|
Epithelium, Erosion | 2| 2 2.0|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | | 1 3.0|
Pulmonary Artery, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 2 1 2 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 1 2 | 42 2.0|
Atrium, Thrombosis | 3 2 4 3 | 7 2.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Degeneration, Cystic | | 1 2.0|
Degeneration, Fatty | 1 3 1 1 2 1 2 1 2 1 1 2 2 1 2| 28 1.4|
Hyperplasia | 2 2 1 1 1 1 1 | 13 1.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 1 2 1 1 1 1 2 2 | 18 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 47 |
Hyperplasia | 2 2 | 9 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Craniopharyngeal Duct, Cyst | 1 | 1 1.0|
Pars Distalis, Cyst | 2 1 | 7 1.9|
Pars Distalis, Hyperplasia | 1 1 1 1 2 1 1 1 1 2 2 | 22 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 2 1 1 2 1 2| 16 1.6|
Follicular Cell, Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| |
DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| |
| 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 | 7 2.4|
Inflammation, Chronic Active | 2 2 1 2 2 2 3 1 2 2 1 3 2 2 2 2 2 2 2 2 2 | 42 1.9|
Duct, Cyst | 4 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 2 1 2 1 2 2 1 2 2 1 2 1 2 2 2 2 1| 38 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation, Chronic | 2 | 1 2.0|
Germinal Epithelium, Atrophy | 2 | 2 3.0|
Interstitial Cell, Hyperplasia | 2 2 1| 10 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 4 4 4 4 4 3 4 3 4 3 4 3 4 4| 30 3.8|
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| 34 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 2 1 1 1 2 1 1 1 1 2 1 1 1| 25 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 1 2| 5 2.0|
Hematopoietic Cell Proliferation | 2 2 | 4 2.8|
Necrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 2 3 2 3 3 2 2 1 2 1 2 3 2 3 2 2 2| 36 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia | | 1 3.0|
Sebaceous Gland, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| |
DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| |
| 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 2 4| 4 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic Active | 1 | 3 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X X X X X X X X X X | 21 |
Inflammation, Chronic Active | 2 2 2 2 4 2 2 4 2 2 3 3 2| 25 2.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 1 | 6 1.7|
Respiratory Epithelium, Hyperplasia | 2 3 3 2 3 3 3 2 3 2 3 3 1| 24 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 3 2| 12 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Nephropathy, Chronic | 1 4 2 2 3 2 2 3 1 2 3 1 2 3 2 2 1 2 2 4 1 1 3 2 2| 50 2.4|
Renal Tubule, Hyperplasia | | 1 3.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1| 49 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7|
DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0|
| 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X X|
Inflammation, Chronic | 2 1 1 1 |
Bile Duct, Hyperplasia | 2 1 3 1 2 3 2 2 2 2 2 2 2 1 1 3 3 1 2 2 3 2 |
Hepatocyte, Degeneration, Cystic | 2 2 2 1 1 1 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 3 1 |
Hepatocyte, Centrilobular, | |
Degeneration | 3 |
Hepatocyte, Centrilobular, Necrosis | 4 2 2 3 |
Oval Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Fat, Necrosis | 4 4 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 4 3 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 |
Epithelium, Hyperplasia | 2 2 3 3 2 2 |
Epithelium, Ulcer | 1 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Atrium, Thrombosis | 3 3 1 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7|
DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0|
| 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Cystic | 2 |
Degeneration, Fatty | 1 2 3 3 2 1 2 3 1|
Hyperplasia | 2 2 2 2 |
Hypertrophy | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
Hyperplasia | 1 1 1 3 2 1 2 3 1 2 3 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + M + + + + + M + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 2 |
Pars Distalis, Hyperplasia | 1 1 2 2 2 3 2|
Pars Intermedia, Cyst | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 4 |
Inflammation, Chronic Active | 2 1 1 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 1 2 3 2 1 1 2 1 3 2 1 1 2|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 |
Atrophy | |
Hyperplasia | 3 3 3 4 4 4 3 4 4 4 4 4 4 4 4 4 4|
Myelofibrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7|
DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0|
| 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
Ectopic Parathyroid Gland | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 1 2 2 2 2 4 2 2 2 2 2 4 1 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Granulomatous | |
Epidermis, Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X X X X X X X X X X|
Inflammation, Chronic Active | 2 3 3 2 2 2 3 3 4 3 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 3 2|
Respiratory Epithelium, Hyperplasia | 3 2 3 2 2 3 3 3 3 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 3 2 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 6| 7| 6| 6| 7| 5| 5| 4| 5| 5| 5| 6| 7| 6| 6| 6| 7| 5| 6| 7|
DAY ON TEST | 3| 1| 3| 2| 2| 4| 3| 0| 8| 3| 6| 6| 5| 4| 2| 0| 6| 2| 1| 3| 3| 2| 7| 1| 0|
| 7| 0| 7| 8| 2| 9| 7| 5| 4| 7| 3| 3| 0| 4| 4| 5| 0| 3| 4| 1| 4| 6| 9| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
Lens, Cataract | 3 |
Retina, Atrophy | 3 3|
Retina, Hemorrhage | 2|
Sclera, Metaplasia, Osseous | 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | |
Cyst | |
Nephropathy, Chronic | 2 2 2 2 1 2 2 1 2 2 2 2 1 4 2 2 2 2 2 1 2 1 2 2|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2 1 1 1 3 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| |
| 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X | 14 |
Clear Cell Focus | X X | 2 |
Eosinophilic Focus | | 2 |
Hepatodiaphragmatic Nodule | X X X X | 7 |
Inflammation, Chronic | 1 1 1 2 1 1 2 1 1 1 1 1 | 16 1.2|
Bile Duct, Hyperplasia | 3 2 2 3 2 1 2 1 3 2 1 1 1 2 2 2 3 2 2 3 3 2 2 3 3| 47 2.1|
Hepatocyte, Degeneration, Cystic | 1 1 1 1 2 1 1 1 1 1 1 2 1 2| 22 1.3|
Hepatocyte, Vacuolization Cytoplasmic| | 3 1.7|
Hepatocyte, Centrilobular, | | |
Degeneration | | 1 3.0|
Hepatocyte, Centrilobular, Necrosis | | 4 2.8|
Oval Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 12 |
Fat, Necrosis | 4 4 | 8 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Pharyngeal, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 3 1 2 1 1 1 2 1 1 1 1| 27 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 4 1.8|
Epithelium, Hyperplasia | 2 2| 8 2.3|
Epithelium, Ulcer | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| |
| 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 41 1.9|
Atrium, Thrombosis | 4 3 | 7 3.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 2.0|
Degeneration, Fatty | 1 1 2 1 2 1 3 1 2 3 | 19 1.8|
Hyperplasia | 2 1 2 2 1 2 3 | 11 1.9|
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | | 1 2.0|
Hyperplasia | 1 4 2 2 2 4 2 1 2 1 1 2 3| 27 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + M + +| 45 |
Hyperplasia | 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 1 1 2 2 3 2 | 8 2.0|
Pars Distalis, Hyperplasia | 2 2 1 2 2 1 | 13 1.8|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 1 2.0|
C-Cell, Hyperplasia | 1 1 1 1 | 8 1.1|
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 4 | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 4 2 | 7 3.3|
Inflammation, Chronic Active | 1 2 2 3 2 2 1 1 3 2 1 2 2 2 2 2 2 2 2 2 2 2 | 40 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 1 2 2 2 1 1 1 3 1 1 4 2 3 1 1 1| 34 1.7|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| |
| 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 4 | 2 4.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 4.0|
Atrophy | 4 | 1 4.0|
Hyperplasia | 4 4 3 3 4 3 3 4 4 3 4 4 3 3 4 4| 33 3.7|
Myelofibrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 34 |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 | 19 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erythrophagocytosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + M + M + + + + + + + +| 46 |
Ectopic Parathyroid Gland | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Hyperplasia, Cystic | 1 1 4 1 2 3 2 1 2 1 2 3 2 2 2 2 2 2| 34 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Granulomatous | 2 | 1 2.0|
Epidermis, Hyperkeratosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 0| 4| 2| 6| 3| 9| 3| 3| 4| 3| 3| 3| 3| 3| 6| 3| 3| 0| 1| 3| 3| 9| 9| |
| 4| 7| 7| 7| 3| 3| 7| 2| 7| 7| 4| 5| 7| 7| 7| 7| 3| 7| 7| 2| 9| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 4 1 2 2 3 | 5 2.4|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 3 1 1 1| 37 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X X X | 15 |
Inflammation, Chronic Active | 2 2 1 1 2 1 1 2 | 19 2.2|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 3 | 6 2.0|
Respiratory Epithelium, Hyperplasia | 2 2 2 4 2 3 | 16 2.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 3 2 | 9 2.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Lens, Cataract | 4 3 | 3 3.3|
Retina, Atrophy | 4 4 | 4 3.5|
Retina, Hemorrhage | | 1 2.0|
Sclera, Metaplasia, Osseous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 3 | 1 3.0|
Cyst | 3 2 3 3 | 4 2.8|
Nephropathy, Chronic | 1 2 3 2 4 4 3 2 2 3 2 2 2 3 2 3 2 3 2 1 2 3 2 2 2| 49 2.1|
Renal Tubule, Pigmentation | 1 1 2 1 2 1 1 2 2 1 1 1 2 1 1 1 2 1 1 2 1 1 1 4 3| 48 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6|
DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2|
| 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 2 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 1 1 2 3 2 3 2 2 2 1 2 2 1 2 2 2 3 3 3 2 2 2 3 2|
Hepatocyte, Degeneration, Cystic | 1 1 1 3 1 1 2 1 2 1 1 1 2 1 3 |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 1 |
Hepatocyte, Centrilobular, | |
Degeneration | |
Hepatocyte, Centrilobular, Necrosis | 3 |
Portal Vein, Thrombosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + +|
Accessory Spleen | X |
Fat, Necrosis | 4 4 4 4 4 |
__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 4 1 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia, Basal Cell | 2 |
Epithelium, Hyperplasia | 3 |
Epithelium, Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Ulcer | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6|
DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2|
| 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 1 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 3 2 |
Inflammation, Suppurative | |
Atrium, Thrombosis | 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Degeneration, Cystic | 1|
Degeneration, Fatty | 2 1 3 1 2 1 1 2 1 1 3|
Hyperplasia | 1 2 1 1 1 2 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 1 1 2 1 1 2 2 3 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 1 2 2 2 2 1 2 |
Pars Intermedia, Cyst | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 2 1 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 2 1 2 2 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 3 1 2 2 1 2 1 1 2 2 2 4 2 2 2 2 2|
Duct, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 1 1 2 1 4 3 1 2 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 4 4 |
Interstitial Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6|
DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2|
| 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 4 3 4 4 3 4 4 3 4 4 4 4 3 3 3 4 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Necrosis | 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 1 1 2 1 1 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Cystic | 2 1 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epidermis, Hyperkeratosis | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3|
Inflammation, Suppurative | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 6| 5| 7| 7| 5| 7| 6|
DAY ON TEST | 1| 4| 3| 3| 8| 9| 3| 3| 6| 1| 7| 3| 3| 0| 3| 4| 4| 3| 4| 7| 3| 3| 8| 0| 2|
| 1| 3| 7| 7| 8| 8| 7| 7| 6| 9| 6| 7| 7| 5| 7| 8| 0| 7| 0| 2| 7| 7| 3| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
400 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X X X |
Hemorrhage | 4 |
Inflammation, Chronic Active | 1 3 1 3 1 2 3 1 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
Respiratory Epithelium, Hyperplasia | 2 3 1 2 1 3 3 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Inflammation, Suppurative | |
Nephropathy, Chronic | 2 2 2 2 2 3 3 3 2 1 3 2 2 2 3 2 3 2 2 2 2 2 2 2 2|
Renal Tubule, Pigmentation | 1 1 1 2 2 1 2 1 2 2 1 1 1 1 1 1 2 1 2 2 1 1 1 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| |
DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| |
| 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X| 20 |
Clear Cell Focus | X X | 7 |
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X X X X X | 6 |
Inflammation, Chronic | 1 1 2 1 1 1 2 2 1 2 1 1| 22 1.3|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | 2 2 2 3 2 2 2 3 2 2 2 3 3 2 2 2 2 2 2 2 2 2 | 46 2.1|
Hepatocyte, Degeneration, Cystic | 1 2 2 1 2 2 1 2 1 1 2 1 2 | 28 1.5|
Hepatocyte, Necrosis | 1 1 | 2 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 | 5 1.2|
Hepatocyte, Centrilobular, | | |
Degeneration | 2 | 1 2.0|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
Portal Vein, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 15 |
Accessory Spleen | | 1 |
Fat, Necrosis | 4 4 4 | 8 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Gingival, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 2 1 1 1 1 1 | 16 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 1| 3 2.0|
Epithelium, Hyperplasia, Basal Cell | 1 | 2 1.5|
Epithelium, Hyperplasia | 3 2 2| 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| |
DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| |
| 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Ulcer | 4 4 2 | 4 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epithelium, Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 2 3 3 2 1 2 2 2 2 2 2 2 2 2 2 2 1| 41 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Atrium, Thrombosis | 2 3 | 4 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Degeneration, Cystic | | 1 1.0|
Degeneration, Fatty | 1 2 4 1 3 | 16 1.8|
Hyperplasia | 1 2 1 1 2 | 13 1.5|
Hypertrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 4 4 3 1 3 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + M + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 |
Pars Distalis, Cyst | 1 | 3 1.3|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 1 2 1 2 1 1 2 1| 15 1.5|
Pars Intermedia, Cyst | 2 | 3 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 1 2 1 1 2 1 1 1 1 | 21 1.3|
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| |
DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| |
| 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 7 2.4|
Inflammation, Chronic Active | 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2 2 1 3 | 47 1.9|
Duct, Cyst | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 1 1 3 2 1 2 1 1 3 2 1 2 1 1 1 1 1| 32 1.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 4 | 4 4.0|
Interstitial Cell, Hyperplasia | 1 1 1 1| 6 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hyperplasia | 4 3 3 3 4 3 4 3 4 4 4 4 3 4 3 4 3 4 4| 36 3.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 35 |
Mediastinal, Hyperplasia, Lymphoid | 1 | 3 1.7|
Mediastinal, Necrosis | | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 2 1 1 1 1 1 2 1 | 23 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 2 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 | 3 2.3|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Hyperplasia, Cystic | 1 2 1 1 1 1 2 1 3 1 1 1 1 | 24 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| |
DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| |
| 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Epidermis, Hyperkeratosis | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 3 2 3 3 | 6 2.8|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 | 5 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 | 39 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | X X X X X X | 10 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic Active | 2 2 3 1 2 3 2 1 3 2 3 1 | 22 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 2 2 | 6 1.7|
Respiratory Epithelium, Hyperplasia | 3 3 3 1 3 3 2 3 2 | 17 2.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 2 2 | 8 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Infarct | 4 | 1 4.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 5| 5| 7| 5| 7| 7| 7| 5| 4| 6| 3| |
DAY ON TEST | 9| 3| 6| 3| 3| 3| 3| 2| 4| 3| 2| 3| 2| 3| 5| 9| 3| 2| 3| 2| 3| 6| 8| 1| 6| |
| 3| 7| 1| 7| 7| 7| 7| 2| 5| 7| 7| 7| 0| 7| 7| 3| 7| 1| 7| 9| 7| 3| 2| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 1 2 2 2 2 3 3 2 2 2 2 3 2 3 2 2 2 1 3 2 1 2 2 2 2| 50 2.1|
Renal Tubule, Pigmentation | 1 1 2 2 1 1 1 1 2 1 1 1 1 2 1 3 1 1 1 1 2 2 1 1 | 49 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 3| 3| 3| 0| 0| 4| 1| 3| 6| 3| 1| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 1|
| 8| 7| 6| 7| 8| 2| 4| 0| 7| 0| 6| 2| 7| 7| 7| 0| 7| 7| 1| 6| 6| 7| 6| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 1 1 2 1 2 2 1 1 1 1 2 1 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 3 2 3 2 3 2 3 3 2 2 3 2 2 2 1 2 2 2 2 2 2 2 2|
Hepatocyte, Degeneration, Cystic | 3 2 2 2 1 1 2 1 1 1 1 2 1 1 2 1 2 1 3 |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 1 1 |
Hepatocyte, Centrilobular, | |
Degeneration | |
Hepatocyte, Centrilobular, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic Active | |
Fat, Necrosis | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 2 1 2 1 1 2 1 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 |
Epithelium, Hyperplasia | 1 2 |
Epithelium, Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Epithelium, Erosion | 2|
Epithelium, Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 3| 3| 3| 0| 0| 4| 1| 3| 6| 3| 1| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 1|
| 8| 7| 6| 7| 8| 2| 4| 0| 7| 0| 6| 2| 7| 7| 7| 0| 7| 7| 1| 6| 6| 7| 6| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 3 2 2 3 2 1 2 2 2 2 2 2 2 2 2|
Mineralization | |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 1 2 1 1 1 2 2 2|
Hyperplasia | 2 2 2 2 1 1 |
Hypertrophy | 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 2 1 3 2 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia | 2 1 1 3 2 2 2 2 1 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | 2 |
C-Cell, Hyperplasia | 1 1 1 2 1 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 3 1 1 1 3 3 2 1 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 2 |
Interstitial Cell, Hyperplasia | 1 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 3 4 4 4 4 4 4 3 3 3 4 4 3 4|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 89002-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 11:06:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 0| 3| 3| 3| 0| 0| 4| 1| 3| 6| 3| 1| 3| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 1|
| 8| 7| 6| 7| 8| 2| 4| 0| 7| 0| 6| 2| 7| 7| 7| 0| 7| 7| 1| 6| 6| 7| 6| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
600 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 1 2 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2 |
Pancreatic, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Cystic | 1 3 2 1 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclus