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TDMS Study 89002-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97

EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:47:38
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 09/15/97     
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 16:47:38     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                PENTACHLOROPHENOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Degeneration Fatty
Adrenal Medulla                        Hyperplasia
Heart                                  Cardiomyopathy Chronic
Heart: Atrium                          Thrombosis
Kidney                                 Nephropathy Chronic
Kidney: Renal Tubule                   Pigmentation
Liver                                  Basophilic Focus
                                       Hepatodiaphragmatic Nodule
                                       Inflammation Chronic
Liver: Bile Duct                       Hyperplasia
Liver: Hepatocyte                      Degeneration Cystic
Lung: Alveolus                         Infiltration Cellular Histiocyte
Lymph Node, Mediastinal                Pigmentation Hemosiderin
Lymph Node, Mesenteric                 Ectasia
Mammary Gland                          Hyperplasia Cystic
Mesentery: Fat                         Necrosis
Nose                                   Fungus
                                       Inflammation Chronic
Nose: Respiratory Epithelium           Hyperplasia
                                       Metaplasia
Preputial Gland                        Inflammation Chronic
Prostate                               Inflammation Chronic
Stomach, Forestomach                   Inflammation Chronic
Stomach, Forestomach: Epithelium       Ulcer
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Hyperplasia
Kidney                                 Nephropathy Chronic
Nose: Respiratory Epithelium           Hyperplasia
Pituitary Gland: Pars Distalis         Cyst
===============================================================
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)    |           1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     4.7%         |           2.4%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           1/28 (4%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      565          |           738 (T)                  ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.273      |                                    P=0.500N        |
|POLY 3             |                                           P=0.253      |                                    P=0.487N        |
|POLY 1.5           |                                           P=0.245      |                                    P=0.495N        |
|POLY 6             |                                           P=0.269      |                                    P=0.478N        |
|LOGISTIC REGRESSION|                                           P=0.224      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.247      |                                    P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)    |           0/50 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     2.4%         |           0.0%                     4.7%            |
|TERMINAL (d)       |                  1/12 (8%)                1/27 (4%)    |           0/28 (0%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  736 (T)                  736 (T)      |           ---                      600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.571N     |                                    P=0.250         |
|POLY 3             |                                           P=0.725N     |                                    P=0.242         |
|POLY 1.5           |                                           P=0.743N     |                                    P=0.239         |
|POLY 6             |                                           P=0.695N     |                                    P=0.246         |
|LOGISTIC REGRESSION|                                           P=0.571N     |                                    P=0.238         |
|COCH-ARM / FISHERS |                                           P=0.753N     |                                    P=0.247         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  28/50 (56%)              25/50 (50%)  |           9/50 (18%)               14/50 (28%)     |
|POLY-3 ADJUSTED (b)|                  63.2%                    54.1%        |           21.2%                    32.2%           |
|TERMINAL (d)       |                  8/12 (67%)               12/27 (44%)  |           4/28 (14%)               8/28 (29%)      |
|FIRST INCIDENCE    |                  396                      360          |           585                      647             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.017N*    |                                    P=0.219         |
|POLY 3             |                                           P=0.245N     |                                    P=0.180         |
|POLY 1.5           |                                           P=0.299N     |                                    P=0.171         |
|POLY 6             |                                           P=0.164N     |                                    P=0.188         |
|LOGISTIC REGRESSION|                                           P=0.354N     |                                    P=0.192         |
|COCH-ARM / FISHERS |                                           P=0.344N     |                                    P=0.171         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  13/50 (26%)              17/50 (34%)  |           7/50 (14%)               17/50 (34%)     |
|POLY-3 ADJUSTED (b)|                  32.2%                    39.1%        |           17.0%                    39.3%           |
|TERMINAL (d)       |                  4/12 (33%)               13/27 (48%)  |           6/28 (21%)               14/28 (50%)     |
|FIRST INCIDENCE    |                  564                      460          |           698                      600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.280N     |                                    P=0.016 *       |
|POLY 3             |                                           P=0.326      |                                    P=0.017 *       |
|POLY 1.5           |                                           P=0.290      |                                    P=0.016 *       |
|POLY 6             |                                           P=0.384      |                                    P=0.019 *       |
|LOGISTIC REGRESSION|                                           P=0.318      |                                    P=0.021 *       |
|COCH-ARM / FISHERS |                                           P=0.257      |                                    P=0.017 *       |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)    |           1/50 (2%)                3/50 (6%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     7.2%         |           2.4%                     7.1%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           1/28 (4%)                3/28 (11%)      |
|FIRST INCIDENCE    |                  ---                      677          |           738 (T)                  738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.253      |                                    P=0.304         |
|POLY 3             |                                           P=0.133      |                                    P=0.314         |
|POLY 1.5           |                                           P=0.125      |                                    P=0.308         |
|POLY 6             |                                           P=0.148      |                                    P=0.320         |
|LOGISTIC REGRESSION|                                           P=0.163      |                                    P=0.304         |
|COCH-ARM / FISHERS |                                           P=0.121      |                                    P=0.309         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  18/50 (36%)              28/50 (56%)  |           3/50 (6%)                4/50 (8%)       |
|POLY-3 ADJUSTED (b)|                  46.2%                    61.2%        |           7.3%                     9.2%            |
|TERMINAL (d)       |                  6/12 (50%)               17/27 (63%)  |           3/28 (11%)               2/28 (7%)       |
|FIRST INCIDENCE    |                  647                      460          |           738 (T)                  516             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.396N     |                                    P=0.509         |
|POLY 3             |                                           P=0.108      |                                    P=0.529         |
|POLY 1.5           |                                           P=0.061      |                                    P=0.513         |
|POLY 6             |                                           P=0.228      |                                    P=0.546         |
|LOGISTIC REGRESSION|                                           P=0.080      |                                    P=0.501         |
|COCH-ARM / FISHERS |                                           P=0.035 *    |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Aorta                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     4.8%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  715                      684          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.670      |                                    (e)             |
|POLY 3             |                                           P=0.527      |                                    (e)             |
|POLY 1.5           |                                           P=0.513      |                                    (e)             |
|POLY 6             |                                           P=0.551      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.575      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)    |           0/50 (0%)                0/49 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     7.2%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  715                      684          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.488      |                                    (e)             |
|POLY 3             |                                           P=0.336      |                                    (e)             |
|POLY 1.5           |                                           P=0.320      |                                    (e)             |
|POLY 6             |                                           P=0.366      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.382      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.309      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteopetrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           6/50 (12%)               2/49 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           14.5%                    4.8%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           3/28 (11%)               0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           698                      708             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.128N        |
|POLY 3             |                                           (e)          |                                    P=0.128N        |
|POLY 1.5           |                                           (e)          |                                    P=0.136N        |
|POLY 6             |                                           (e)          |                                    P=0.121N        |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.124N        |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.141N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  30/50 (60%)              38/50 (76%)  |           11/50 (22%)              16/49 (33%)     |
|POLY-3 ADJUSTED (b)|                  67.6%                    79.3%        |           25.3%                    34.4%           |
|TERMINAL (d)       |                  5/12 (42%)               21/27 (78%)  |           3/28 (11%)               2/28 (7%)       |
|FIRST INCIDENCE    |                  396                      360          |           475                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.181N     |                                    P=0.262         |
|POLY 3             |                                           P=0.137      |                                    P=0.234         |
|POLY 1.5           |                                           P=0.098      |                                    P=0.200         |
|POLY 6             |                                           P=0.195      |                                    P=0.275         |
|LOGISTIC REGRESSION|                                           P=0.081      |                                    P=0.163         |
|COCH-ARM / FISHERS |                                           P=0.066      |                                    P=0.168         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  4/50 (8%)                1/50 (2%)    |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  10.3%                    2.4%         |           0.0%                     2.3%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  564                      736 (T)      |           ---                      652             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.112N     |                                    P=0.520         |
|POLY 3             |                                           P=0.154N     |                                    P=0.500         |
|POLY 1.5           |                                           P=0.166N     |                                    P=0.500         |
|POLY 6             |                                           P=0.135N     |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.190N     |                                    P=0.503         |
|COCH-ARM / FISHERS |                                           P=0.181N     |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |           10/50 (20%)              10/49 (20%)     |
|POLY-3 ADJUSTED (b)|                                                        |           23.7%                    24.0%           |
|TERMINAL (d)       |                                                        |           6/28 (21%)               9/27 (33%)      |
|FIRST INCIDENCE    |                                                        |           523                      703             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |                                    P=0.587         |
|POLY 3             |                                                        |                                    P=0.588         |
|POLY 1.5           |                                                        |                                    P=0.578         |
|POLY 6             |                                                        |                                    P=0.592         |
|LOGISTIC REGRESSION|                                                        |                                    P=0.577N        |
|COCH-ARM / FISHERS |                                                        |                                    P=0.579         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |           4/50 (8%)                3/49 (6%)       |
|POLY-3 ADJUSTED (b)|                                                        |           9.4%                     7.2%            |
|TERMINAL (d)       |                                                        |           1/28 (4%)                2/27 (7%)       |
|FIRST INCIDENCE    |                                                        |           544                      668             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |                                    P=0.482N        |
|POLY 3             |                                                        |                                    P=0.510N        |
|POLY 1.5           |                                                        |                                    P=0.515N        |
|POLY 6             |                                                        |                                    P=0.508N        |
|LOGISTIC REGRESSION|                                                        |                                    P=0.510N        |
|COCH-ARM / FISHERS |                                                        |                                    P=0.511N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Coagulating Gland                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/2 (100%)               0/0 (0%)     |           0/0 (0%)                 0/0 (0%)        |
|POLY-3 ADJUSTED (b)|                  100.0%                   0.0%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/0 (0%)                 0/0 (0%)     |           0/0 (0%)                 0/0 (0%)        |
|FIRST INCIDENCE    |                  715                      ---          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    (e)             |
|POLY 3             |                                           (e)          |                                    (e)             |
|POLY 1.5           |                                           (e)          |                                    (e)             |
|POLY 6             |                                           (e)          |                                    (e)             |
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             |
|COCH-ARM / FISHERS |                                           (e)          |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/1 (0%)                 0/3 (0%)     |           2/3 (67%)                1/2 (50%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           70.3%                    50.0%           |
|TERMINAL (d)       |                  0/0 (0%)                 0/1 (0%)     |           2/2 (100%)               0/1 (0%)        |
|FIRST INCIDENCE    |                  ---                      ---          |           738 (T)                  701             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.682N        |
|POLY 3             |                                           (e)          |                                    P=0.702N        |
|POLY 1.5           |                                           (e)          |                                    P=0.712N        |
|POLY 6             |                                           (e)          |                                    P=0.684N        |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.737N        |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.700N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Lens                                                                                                                        |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/1 (100%)               3/3 (100%)   |           0/3 (0%)                 0/2 (0%)        |
|POLY-3 ADJUSTED (b)|                  100.0%                   100.0%       |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/0 (0%)                 1/1 (100%)   |           0/2 (0%)                 0/1 (0%)        |
|FIRST INCIDENCE    |                  396                      677          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    (e)             |
|POLY 3             |                                           (e)          |                                    (e)             |
|POLY 1.5           |                                           (e)          |                                    (e)             |
|POLY 6             |                                           (e)          |                                    (e)             |
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             |
|COCH-ARM / FISHERS |                                           (e)          |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/1 (100%)               3/3 (100%)   |           0/3 (0%)                 0/2 (0%)        |
|POLY-3 ADJUSTED (b)|                  100.0%                   100.0%       |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/0 (0%)                 1/1 (100%)   |           0/2 (0%)                 0/1 (0%)        |
|FIRST INCIDENCE    |                  396                      677          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    (e)             |
|POLY 3             |                                           (e)          |                                    (e)             |
|POLY 1.5           |                                           (e)          |                                    (e)             |
|POLY 6             |                                           (e)          |                                    (e)             |
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             |
|COCH-ARM / FISHERS |                                           (e)          |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy Chronic                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  41/50 (82%)              45/50 (90%)  |           27/50 (54%)              25/50 (50%)     |
|POLY-3 ADJUSTED (b)|                  87.8%                    94.2%        |           58.9%                    56.8%           |
|TERMINAL (d)       |                  12/12 (100%)             26/27 (96%)  |           15/28 (54%)              17/28 (61%)     |
|FIRST INCIDENCE    |                  396                      265          |           461                      600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.012N*    |                                    P=0.386N        |
|POLY 3             |                                           P=0.205      |                                    P=0.509N        |
|POLY 1.5           |                                           P=0.186      |                                    P=0.488N        |
|POLY 6             |                                           P=0.268      |                                    P=0.543N        |
|LOGISTIC REGRESSION|                                           P=0.244      |                                    P=0.390N        |
|COCH-ARM / FISHERS |                                           P=0.194      |                                    P=0.421N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  7/50 (14%)               1/50 (2%)    |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  18.5%                    2.4%         |           0.0%                     2.3%            |
|TERMINAL (d)       |                  3/12 (25%)               0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  684                      708          |           ---                      668             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.003N**   |                                    P=0.527         |
|POLY 3             |                                           P=0.019N*    |                                    P=0.500         |
|POLY 1.5           |                                           P=0.024N*    |                                    P=0.500         |
|POLY 6             |                                           P=0.012N*    |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.008N**   |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.030N*    |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                3/49 (6%)    |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     7.2%         |           0.0%                     2.4%            |
|TERMINAL (d)       |                  1/12 (8%)                2/27 (7%)    |           0/28 (0%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  736 (T)                  565          |           ---                      738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.536      |                                    P=0.500         |
|POLY 3             |                                           P=0.334      |                                    P=0.500         |
|POLY 1.5           |                                           P=0.316      |                                    P=0.500         |
|POLY 6             |                                           P=0.365      |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.327      |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.301      |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                5/50 (10%)   |           2/50 (4%)                4/50 (8%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     12.0%        |           4.9%                     9.2%            |
|TERMINAL (d)       |                  0/12 (0%)                5/27 (19%)   |           2/28 (7%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  643                      736 (T)      |           738 (T)                  516             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.322      |                                    P=0.353         |
|POLY 3             |                                           P=0.120      |                                    P=0.359         |
|POLY 1.5           |                                           P=0.110      |                                    P=0.347         |
|POLY 6             |                                           P=0.139      |                                    P=0.372         |
|LOGISTIC REGRESSION|                                           P=0.177      |                                    P=0.338         |
|COCH-ARM / FISHERS |                                           P=0.102      |                                    P=0.339         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     0.0%         |           0.0%                     2.4%            |
|TERMINAL (d)       |                  2/12 (17%)               0/27 (0%)    |           0/28 (0%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  736 (T)                  ---          |           ---                      738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.085N     |                                    P=0.500         |
|POLY 3             |                                           P=0.204N     |                                    P=0.500         |
|POLY 1.5           |                                           P=0.220N     |                                    P=0.500         |
|POLY 6             |                                           P=0.179N     |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)    |           1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     7.2%         |           2.4%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           1/28 (4%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  681                      684          |           738 (T)                  ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.508      |                                    P=0.500N        |
|POLY 3             |                                           P=0.335      |                                    P=0.487N        |
|POLY 1.5           |                                           P=0.320      |                                    P=0.495N        |
|POLY 6             |                                           P=0.362      |                                    P=0.478N        |
|LOGISTIC REGRESSION|                                           P=0.372      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.309      |                                    P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy Chronic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  50/50 (100%)             49/50 (98%)  |           44/50 (88%)              49/50 (98%)     |
|POLY-3 ADJUSTED (b)|                  100.0%                   99.9%        |           95.7%                    100.0%          |
|TERMINAL (d)       |                  12/12 (100%)             27/27 (100%) |           28/28 (100%)             28/28 (100%)    |
|FIRST INCIDENCE    |                  396                      360          |           507                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.002N**   |                                    P=0.326         |
|POLY 3             |                                           P=1.000N     |                                    P=0.103         |
|POLY 1.5           |                                           P=1.000N     |                                    P=0.036 *       |
|POLY 6             |                                           P=1.000N     |                                    P=0.698         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.016 *       |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.056         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     4.8%         |           0.0%                     2.3%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  695                      708          |           ---                      719             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.687      |                                    P=0.513         |
|POLY 3             |                                           P=0.526      |                                    P=0.500         |
|POLY 1.5           |                                           P=0.513      |                                    P=0.500         |
|POLY 6             |                                           P=0.549      |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.579      |                                    P=0.510         |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  49/50 (98%)              47/50 (94%)  |           48/50 (96%)              49/50 (98%)     |
|POLY-3 ADJUSTED (b)|                  98.7%                    94.4%        |           98.4%                    100.0%          |
|TERMINAL (d)       |                  12/12 (100%)             25/27 (93%)  |           28/28 (100%)             28/28 (100%)    |
|FIRST INCIDENCE    |                  396                      265          |           391                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.002N**   |                                    P=0.546N        |
|POLY 3             |                                           P=0.257N     |                                    P=0.640         |
|POLY 1.5           |                                           P=0.279N     |                                    P=0.391         |
|POLY 6             |                                           P=0.227N     |                                    P=0.997         |
|LOGISTIC REGRESSION|                                           P=0.347N     |                                    P=0.290         |
|COCH-ARM / FISHERS |                                           P=0.309N     |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     4.8%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  647                      736 (T)      |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.481N     |                                    (e)             |
|POLY 3             |                                           P=0.651N     |                                    (e)             |
|POLY 1.5           |                                           P=0.673N     |                                    (e)             |
|POLY 6             |                                           P=0.615N     |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.631N     |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.691N     |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  17/50 (34%)              31/50 (62%)  |           41/50 (82%)              34/50 (68%)     |
|POLY-3 ADJUSTED (b)|                  42.0%                    71.2%        |           86.2%                    76.3%           |
|TERMINAL (d)       |                  10/12 (83%)              25/27 (93%)  |           27/28 (96%)              27/28 (96%)     |
|FIRST INCIDENCE    |                  396                      550          |           391                      516             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.522N     |                                    P=0.088N        |
|POLY 3             |                                           P=0.003 **   |                                    P=0.150N        |
|POLY 1.5           |                                           P=0.003 **   |                                    P=0.132N        |
|POLY 6             |                                           P=0.006 **   |                                    P=0.178N        |
|LOGISTIC REGRESSION|                                           P=0.013 *    |                                    P=0.058N        |
|COCH-ARM / FISHERS |                                           P=0.004 **   |                                    P=0.083N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  6/50 (12%)               9/50 (18%)   |           11/50 (22%)              16/50 (32%)     |
|POLY-3 ADJUSTED (b)|                  16.0%                    21.6%        |           26.8%                    37.5%           |
|TERMINAL (d)       |                  6/12 (50%)               9/27 (33%)   |           11/28 (39%)              15/28 (54%)     |
|FIRST INCIDENCE    |                  736 (T)                  736 (T)      |           738 (T)                  690             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.267N     |                                    P=0.155         |
|POLY 3             |                                           P=0.360      |                                    P=0.203         |
|POLY 1.5           |                                           P=0.322      |                                    P=0.188         |
|POLY 6             |                                           P=0.431      |                                    P=0.220         |
|LOGISTIC REGRESSION|                                           P=0.267N     |                                    P=0.179         |
|COCH-ARM / FISHERS |                                           P=0.288      |                                    P=0.184         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                7/50 (14%)   |           2/50 (4%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     16.8%        |           4.8%                     4.7%            |
|TERMINAL (d)       |                  0/12 (0%)                7/27 (26%)   |           1/28 (4%)                2/28 (7%)       |
|FIRST INCIDENCE    |                  619                      736 (T)      |           620                      738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.356      |                                    P=0.690N        |
|POLY 3             |                                           P=0.098      |                                    P=0.683N        |
|POLY 1.5           |                                           P=0.088      |                                    P=0.691N        |
|POLY 6             |                                           P=0.119      |                                    P=0.678N        |
|LOGISTIC REGRESSION|                                           P=0.173      |                                    P=0.685N        |
|COCH-ARM / FISHERS |                                           P=0.080      |                                    P=0.691N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                5/50 (10%)   |           9/50 (18%)               10/50 (20%)     |
|POLY-3 ADJUSTED (b)|                  0.0%                     12.0%        |           21.1%                    22.5%           |
|TERMINAL (d)       |                  0/12 (0%)                3/27 (11%)   |           6/28 (21%)               3/28 (11%)      |
|FIRST INCIDENCE    |                  ---                      715          |           475                      472             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.130      |                                    P=0.535         |
|POLY 3             |                                           P=0.038 *    |                                    P=0.538         |
|POLY 1.5           |                                           P=0.034 *    |                                    P=0.515         |
|POLY 6             |                                           P=0.047 *    |                                    P=0.566         |
|LOGISTIC REGRESSION|                                           P=0.080      |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.028 *    |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  22/50 (44%)              34/50 (68%)  |           31/50 (62%)              36/50 (72%)     |
|POLY-3 ADJUSTED (b)|                  51.3%                    71.8%        |           69.4%                    78.4%           |
|TERMINAL (d)       |                  9/12 (75%)               20/27 (74%)  |           22/28 (79%)              27/28 (96%)     |
|FIRST INCIDENCE    |                  396                      265          |           507                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.449N     |                                    P=0.236         |
|POLY 3             |                                           P=0.028 *    |                                    P=0.214         |
|POLY 1.5           |                                           P=0.018 *    |                                    P=0.195         |
|POLY 6             |                                           P=0.060      |                                    P=0.217         |
|LOGISTIC REGRESSION|                                           P=0.012 *    |                                    P=0.225         |
|COCH-ARM / FISHERS |                                           P=0.013 *    |                                    P=0.198         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                5/50 (10%)   |           7/50 (14%)               5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                  2.7%                     12.0%        |           17.0%                    11.7%           |
|TERMINAL (d)       |                  1/12 (8%)                5/27 (19%)   |           7/28 (25%)               4/28 (14%)      |
|FIRST INCIDENCE    |                  736 (T)                  736 (T)      |           738 (T)                  714             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.371      |                                    P=0.372N        |
|POLY 3             |                                           P=0.122      |                                    P=0.350N        |
|POLY 1.5           |                                           P=0.111      |                                    P=0.368N        |
|POLY 6             |                                           P=0.143      |                                    P=0.331N        |
|LOGISTIC REGRESSION|                                           P=0.371      |                                    P=0.353N        |
|COCH-ARM / FISHERS |                                           P=0.102      |                                    P=0.380N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           1/50 (2%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           2.4%                     4.6%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           704                      472             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.526         |
|POLY 3             |                                           (e)          |                                    P=0.513         |
|POLY 1.5           |                                           (e)          |                                    P=0.506         |
|POLY 6             |                                           (e)          |                                    P=0.520         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.522         |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           4.8%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           391                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.241N        |
|POLY 3             |                                           (e)          |                                    P=0.233N        |
|POLY 1.5           |                                           (e)          |                                    P=0.238N        |
|POLY 6             |                                           (e)          |                                    P=0.228N        |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.186N        |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  49/50 (98%)              46/50 (92%)  |           24/50 (48%)              18/50 (36%)     |
|POLY-3 ADJUSTED (b)|                  99.1%                    96.1%        |           56.1%                    41.6%           |
|TERMINAL (d)       |                  12/12 (100%)             27/27 (100%) |           16/28 (57%)              13/28 (46%)     |
|FIRST INCIDENCE    |                  396                      265          |           585                      647             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P<0.001N**   |                                    P=0.146N        |
|POLY 3             |                                           P=0.358N     |                                    P=0.122N        |
|POLY 1.5           |                                           P=0.272N     |                                    P=0.140N        |
|POLY 6             |                                           P=0.473N     |                                    P=0.111N        |
|LOGISTIC REGRESSION|                                           P=0.149N     |                                    P=0.085N        |
|COCH-ARM / FISHERS |                                           P=0.181N     |                                    P=0.156N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  16/50 (32%)              28/50 (56%)  |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  40.1%                    63.0%        |           0.0%                     0.0%            |
|TERMINAL (d)       |                  4/12 (33%)               16/27 (59%)  |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  576                      550          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.532      |                                    (e)             |
|POLY 3             |                                           P=0.023 *    |                                    (e)             |
|POLY 1.5           |                                           P=0.015 *    |                                    (e)             |
|POLY 6             |                                           P=0.047 *    |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.035 *    |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.013 *    |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  3/50 (6%)                2/50 (4%)    |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  7.8%                     4.7%         |           0.0%                     2.3%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  535                      536          |           ---                      684             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.423N     |                                    P=0.522         |
|POLY 3             |                                           P=0.450N     |                                    P=0.500         |
|POLY 1.5           |                                           P=0.475N     |                                    P=0.500         |
|POLY 6             |                                           P=0.411N     |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.530N     |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  10/50 (20%)              13/50 (26%)  |           7/50 (14%)               9/50 (18%)      |
|POLY-3 ADJUSTED (b)|                  24.6%                    30.2%        |           16.8%                    20.9%           |
|TERMINAL (d)       |                  1/12 (8%)                10/27 (37%)  |           3/28 (11%)               6/28 (21%)      |
|FIRST INCIDENCE    |                  396                      536          |           645                      684             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.384N     |                                    P=0.417         |
|POLY 3             |                                           P=0.369      |                                    P=0.415         |
|POLY 1.5           |                                           P=0.340      |                                    P=0.400         |
|POLY 6             |                                           P=0.422      |                                    P=0.428         |
|LOGISTIC REGRESSION|                                           P=0.325      |                                    P=0.436         |
|COCH-ARM / FISHERS |                                           P=0.318      |                                    P=0.393         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)    |           0/50 (0%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     4.7%         |           0.0%                     4.7%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  617                      502          |           ---                      704             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.588N     |                                    P=0.257         |
|POLY 3             |                                           P=0.643N     |                                    P=0.242         |
|POLY 1.5           |                                           P=0.668N     |                                    P=0.239         |
|POLY 6             |                                           P=0.603N     |                                    P=0.245         |
|LOGISTIC REGRESSION|                                           P=0.678      |                                    P=0.243         |
|COCH-ARM / FISHERS |                                           P=0.691N     |                                    P=0.247         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)    |           2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     4.7%         |           4.7%                     0.0%            |
|TERMINAL (d)       |                  1/12 (8%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  729                      502          |           391                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.520N     |                                    P=0.237N        |
|POLY 3             |                                           P=0.638N     |                                    P=0.237N        |
|POLY 1.5           |                                           P=0.665N     |                                    P=0.240N        |
|POLY 6             |                                           P=0.592N     |                                    P=0.234N        |
|LOGISTIC REGRESSION|                                           P=0.696      |                                    P=0.142N        |
|COCH-ARM / FISHERS |                                           P=0.691N     |                                    P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  3/50 (6%)                6/50 (12%)   |           12/50 (24%)              15/50 (30%)     |
|POLY-3 ADJUSTED (b)|                  7.7%                     14.3%        |           27.9%                    34.3%           |
|TERMINAL (d)       |                  0/12 (0%)                5/27 (19%)   |           7/28 (25%)               12/28 (43%)     |
|FIRST INCIDENCE    |                  396                      684          |           523                      516             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.547      |                                    P=0.352         |
|POLY 3             |                                           P=0.274      |                                    P=0.338         |
|POLY 1.5           |                                           P=0.256      |                                    P=0.326         |
|POLY 6             |                                           P=0.310      |                                    P=0.341         |
|LOGISTIC REGRESSION|                                           P=0.248      |                                    P=0.342         |
|COCH-ARM / FISHERS |                                           P=0.243      |                                    P=0.326         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)    |           5/50 (10%)               5/50 (10%)      |
|POLY-3 ADJUSTED (b)|                  2.7%                     7.1%         |           12.1%                    11.7%           |
|TERMINAL (d)       |                  1/12 (8%)                2/27 (7%)    |           4/28 (14%)               4/28 (14%)      |
|FIRST INCIDENCE    |                  736 (T)                  460          |           645                      684             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.538      |                                    P=0.619N        |
|POLY 3             |                                           P=0.341      |                                    P=0.610N        |
|POLY 1.5           |                                           P=0.323      |                                    P=0.623N        |
|POLY 6             |                                           P=0.371      |                                    P=0.597N        |
|LOGISTIC REGRESSION|                                           P=0.303      |                                    P=0.596N        |
|COCH-ARM / FISHERS |                                           P=0.309      |                                    P=0.630N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  39/50 (78%)              44/50 (88%)  |           41/50 (82%)              46/50 (92%)     |
|POLY-3 ADJUSTED (b)|                  84.4%                    90.3%        |           89.0%                    96.5%           |
|TERMINAL (d)       |                  10/12 (83%)              24/27 (89%)  |           28/28 (100%)             28/28 (100%)    |
|FIRST INCIDENCE    |                  396                      360          |           461                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.034N*    |                                    P=0.298         |
|POLY 3             |                                           P=0.272      |                                    P=0.116         |
|POLY 1.5           |                                           P=0.194      |                                    P=0.086         |
|POLY 6             |                                           P=0.401      |                                    P=0.177         |
|LOGISTIC REGRESSION|                                           P=0.176      |                                    P=0.108         |
|COCH-ARM / FISHERS |                                           P=0.143      |                                    P=0.117         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  25/50 (50%)              24/50 (48%)  |           30/50 (60%)              26/50 (52%)     |
|POLY-3 ADJUSTED (b)|                  58.0%                    53.6%        |           66.1%                    56.8%           |
|TERMINAL (d)       |                  5/12 (42%)               13/27 (48%)  |           18/28 (64%)              13/28 (46%)     |
|FIRST INCIDENCE    |                  396                      502          |           507                      571             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.035N*    |                                    P=0.261N        |
|POLY 3             |                                           P=0.417N     |                                    P=0.241N        |
|POLY 1.5           |                                           P=0.467N     |                                    P=0.267N        |
|POLY 6             |                                           P=0.334N     |                                    P=0.217N        |
|LOGISTIC REGRESSION|                                           P=0.432N     |                                    P=0.252N        |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.273N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                6/50 (12%)   |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     14.3%        |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                5/27 (19%)   |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      614          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.084      |                                    (e)             |
|POLY 3             |                                           P=0.021 *    |                                    (e)             |
|POLY 1.5           |                                           P=0.018 *    |                                    (e)             |
|POLY 6             |                                           P=0.027 *    |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.031 *    |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.013 *    |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     7.0%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      360          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.201      |                                    (e)             |
|POLY 3             |                                           P=0.136      |                                    (e)             |
|POLY 1.5           |                                           P=0.127      |                                    (e)             |
|POLY 6             |                                           P=0.152      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.108      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.121      |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/49 (0%)                2/49 (4%)    |           2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     4.9%         |           4.9%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           2/28 (7%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      736 (T)      |           738 (T)                  ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.429      |                                    P=0.238N        |
|POLY 3             |                                           P=0.252      |                                    P=0.226N        |
|POLY 1.5           |                                           P=0.244      |                                    P=0.233N        |
|POLY 6             |                                           P=0.266      |                                    P=0.219N        |
|LOGISTIC REGRESSION|                                           P=0.429      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.247      |                                    P=0.247N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  36/49 (73%)              26/49 (53%)  |           43/50 (86%)              45/50 (90%)     |
|POLY-3 ADJUSTED (b)|                  79.7%                    60.9%        |           88.2%                    94.2%           |
|TERMINAL (d)       |                  8/12 (67%)               18/27 (67%)  |           24/28 (86%)              27/28 (96%)     |
|FIRST INCIDENCE    |                  396                      613          |           461                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P<0.001N**   |                                    P=0.509         |
|POLY 3             |                                           P=0.036N*    |                                    P=0.240         |
|POLY 1.5           |                                           P=0.033N*    |                                    P=0.260         |
|POLY 6             |                                           P=0.039N*    |                                    P=0.215         |
|LOGISTIC REGRESSION|                                           P=0.011N*    |                                    P=0.353         |
|COCH-ARM / FISHERS |                                           P=0.029N*    |                                    P=0.380         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  12/15 (80%)              11/15 (73%)  |           3/8 (38%)                3/6 (50%)       |
|POLY-3 ADJUSTED (b)|                  83.4%                    87.8%        |           42.2%                    60.9%           |
|TERMINAL (d)       |                  3/3 (100%)               9/9 (100%)   |           2/5 (40%)                1/1 (100%)      |
|FIRST INCIDENCE    |                  593                      680          |           391                      600             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.011N*    |                                    P=0.322         |
|POLY 3             |                                           P=0.622      |                                    P=0.524         |
|POLY 1.5           |                                           P=0.701      |                                    P=0.540         |
|POLY 6             |                                           P=0.539      |                                    P=0.499         |
|LOGISTIC REGRESSION|                                           P=0.542N     |                                    P=0.531         |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.529         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Fungus                                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  21/50 (42%)              7/50 (14%)   |           6/50 (12%)               2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  49.1%                    16.4%        |           13.9%                    4.7%            |
|TERMINAL (d)       |                  6/12 (50%)               2/27 (7%)    |           1/28 (4%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  396                      565          |           461                      652             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P<0.001N**   |                                    P=0.135N        |
|POLY 3             |                                           P<0.001N**   |                                    P=0.134N        |
|POLY 1.5           |                                           P<0.001N**   |                                    P=0.137N        |
|POLY 6             |                                           P<0.001N**   |                                    P=0.133N        |
|LOGISTIC REGRESSION|                                           P=0.002N**   |                                    P=0.126N        |
|COCH-ARM / FISHERS |                                           P=0.002N**   |                                    P=0.134N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  25/50 (50%)              21/50 (42%)  |           13/50 (26%)              7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                  57.5%                    48.7%        |           29.9%                    15.9%           |
|TERMINAL (d)       |                  7/12 (58%)               13/27 (48%)  |           7/28 (25%)               3/28 (11%)      |
|FIRST INCIDENCE    |                  396                      565          |           461                      11              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.007N**   |                                    P=0.112N        |
|POLY 3             |                                           P=0.266N     |                                    P=0.092N        |
|POLY 1.5           |                                           P=0.279N     |                                    P=0.097N        |
|POLY 6             |                                           P=0.227N     |                                    P=0.089N        |
|LOGISTIC REGRESSION|                                           P=0.197N     |                                    P=0.103N        |
|COCH-ARM / FISHERS |                                           P=0.274N     |                                    P=0.105N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  6/50 (12%)               4/50 (8%)    |           9/50 (18%)               10/50 (20%)     |
|POLY-3 ADJUSTED (b)|                  15.7%                    9.4%         |           21.2%                    22.7%           |
|TERMINAL (d)       |                  1/12 (8%)                1/27 (4%)    |           5/28 (18%)               5/28 (18%)      |
|FIRST INCIDENCE    |                  617                      613          |           523                      11              |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.157N     |                                    P=0.528         |
|POLY 3             |                                           P=0.297N     |                                    P=0.535         |
|POLY 1.5           |                                           P=0.333N     |                                    P=0.521         |
|POLY 6             |                                           P=0.244N     |                                    P=0.549         |
|LOGISTIC REGRESSION|                                           P=0.321N     |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.370N     |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  24/50 (48%)              11/50 (22%)  |           10/50 (20%)              2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  56.1%                    25.8%        |           23.2%                    4.7%            |
|TERMINAL (d)       |                  7/12 (58%)               5/27 (19%)   |           5/28 (18%)               1/28 (4%)       |
|FIRST INCIDENCE    |                  396                      565          |           461                      652             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P<0.001N**   |                                    P=0.018N*       |
|POLY 3             |                                           P=0.003N**   |                                    P=0.013N*       |
|POLY 1.5           |                                           P=0.004N**   |                                    P=0.014N*       |
|POLY 6             |                                           P<0.001N**   |                                    P=0.012N*       |
|LOGISTIC REGRESSION|                                           P=0.004N**   |                                    P=0.016N*       |
|COCH-ARM / FISHERS |                                           P=0.006N**   |                                    P=0.014N*       |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  12/50 (24%)              5/50 (10%)   |           3/50 (6%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  28.8%                    11.8%        |           7.2%                     0.0%            |
|TERMINAL (d)       |                  1/12 (8%)                1/27 (4%)    |           1/28 (4%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  396                      565          |           543                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.017N*    |                                    P=0.125N        |
|POLY 3             |                                           P=0.043N*    |                                    P=0.114N        |
|POLY 1.5           |                                           P=0.049N*    |                                    P=0.118N        |
|POLY 6             |                                           P=0.034N*    |                                    P=0.110N        |
|LOGISTIC REGRESSION|                                           P=0.067N     |                                    P=0.120N        |
|COCH-ARM / FISHERS |                                           P=0.054N     |                                    P=0.121N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |           4/50 (8%)                7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                                                        |           9.6%                     16.2%           |
|TERMINAL (d)       |                                                        |           3/28 (11%)               4/28 (14%)      |
|FIRST INCIDENCE    |                                                        |           573                      571             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |                                    P=0.282         |
|POLY 3             |                                                        |                                    P=0.281         |
|POLY 1.5           |                                                        |                                    P=0.268         |
|POLY 6             |                                                        |                                    P=0.294         |
|LOGISTIC REGRESSION|                                                        |                                    P=0.270         |
|COCH-ARM / FISHERS |                                                        |                                    P=0.262         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  12/50 (24%)              19/50 (38%)  |           10/50 (20%)              13/50 (26%)     |
|POLY-3 ADJUSTED (b)|                  30.6%                    43.3%        |           23.7%                    29.6%           |
|TERMINAL (d)       |                  4/12 (33%)               12/27 (44%)  |           6/28 (21%)               8/28 (29%)      |
|FIRST INCIDENCE    |                  600                      502          |           585                      472             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.477N     |                                    P=0.351         |
|POLY 3             |                                           P=0.160      |                                    P=0.354         |
|POLY 1.5           |                                           P=0.124      |                                    P=0.332         |
|POLY 6             |                                           P=0.231      |                                    P=0.375         |
|LOGISTIC REGRESSION|                                           P=0.163      |                                    P=0.337         |
|COCH-ARM / FISHERS |                                           P=0.097      |                                    P=0.318         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  9/47 (19%)               7/47 (15%)   |           1/46 (2%)                1/45 (2%)       |
|POLY-3 ADJUSTED (b)|                  24.8%                    17.2%        |           2.6%                     2.6%            |
|TERMINAL (d)       |                  3/12 (25%)               1/26 (4%)    |           0/25 (0%)                0/26 (0%)       |
|FIRST INCIDENCE    |                  681                      680          |           704                      708             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.110N     |                                    P=0.743N        |
|POLY 3             |                                           P=0.293N     |                                    P=0.756N        |
|POLY 1.5           |                                           P=0.338N     |                                    P=0.759         |
|POLY 6             |                                           P=0.232N     |                                    P=0.746N        |
|LOGISTIC REGRESSION|                                           P=0.258N     |                                    P=0.763N        |
|COCH-ARM / FISHERS |                                           P=0.392N     |                                    P=0.747         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  7/50 (14%)               6/50 (12%)   |           35/50 (70%)              24/50 (48%)     |
|POLY-3 ADJUSTED (b)|                  18.3%                    14.2%        |           76.0%                    52.4%           |
|TERMINAL (d)       |                  3/12 (25%)               4/27 (15%)   |           23/28 (82%)              13/28 (46%)     |
|FIRST INCIDENCE    |                  579                      614          |           475                      472             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.137N     |                                    P=0.037N*       |
|POLY 3             |                                           P=0.418N     |                                    P=0.012N*       |
|POLY 1.5           |                                           P=0.459N     |                                    P=0.016N*       |
|POLY 6             |                                           P=0.352N     |                                    P=0.009N**      |
|LOGISTIC REGRESSION|                                           P=0.378N     |                                    P=0.018N*       |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.021N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  22/50 (44%)              26/50 (52%)  |           24/50 (48%)              24/50 (48%)     |
|POLY-3 ADJUSTED (b)|                  53.8%                    59.1%        |           53.9%                    52.7%           |
|TERMINAL (d)       |                  6/12 (50%)               17/27 (63%)  |           16/28 (57%)              13/28 (46%)     |
|FIRST INCIDENCE    |                  593                      565          |           475                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.088N     |                                    P=0.524N        |
|POLY 3             |                                           P=0.384      |                                    P=0.540N        |
|POLY 1.5           |                                           P=0.324      |                                    P=0.571N        |
|POLY 6             |                                           P=0.484      |                                    P=0.505N        |
|LOGISTIC REGRESSION|                                           P=0.483      |                                    P=0.569N        |
|COCH-ARM / FISHERS |                                           P=0.274      |                                    P=0.579N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           1/50 (2%)                2/50 (4%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           2.4%                     4.7%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                2/28 (7%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           698                      738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.510         |
|POLY 3             |                                           (e)          |                                    P=0.507         |
|POLY 1.5           |                                           (e)          |                                    P=0.502         |
|POLY 6             |                                           (e)          |                                    P=0.511         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.520         |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  7/50 (14%)               8/49 (16%)   |                                                    |
|POLY-3 ADJUSTED (b)|                  18.2%                    19.4%        |                                                    |
|TERMINAL (d)       |                  5/12 (42%)               6/27 (22%)   |                                                    |
|FIRST INCIDENCE    |                  396                      613          |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.211N     |                                                    |
|POLY 3             |                                           P=0.557      |                                                    |
|POLY 1.5           |                                           P=0.517      |                                                    |
|POLY 6             |                                           P=0.588N     |                                                    |
|LOGISTIC REGRESSION|                                           P=0.580      |                                                    |
|COCH-ARM / FISHERS |                                           P=0.483      |                                                    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  42/50 (84%)              44/49 (90%)  |                                                    |
|POLY-3 ADJUSTED (b)|                  92.0%                    94.5%        |                                                    |
|TERMINAL (d)       |                  12/12 (100%)             26/27 (96%)  |                                                    |
|FIRST INCIDENCE    |                  396                      360          |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.004N**   |                                                    |
|POLY 3             |                                           P=0.465      |                                                    |
|POLY 1.5           |                                           P=0.343      |                                                    |
|POLY 6             |                                           P=0.723      |                                                    |
|LOGISTIC REGRESSION|                                           P=0.377      |                                                    |
|COCH-ARM / FISHERS |                                           P=0.290      |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland: Duct                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)    |                                                    |
|POLY-3 ADJUSTED (b)|                  5.3%                     0.0%         |                                                    |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |                                                    |
|FIRST INCIDENCE    |                  561                      ---          |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.172N     |                                                    |
|POLY 3             |                                           P=0.215N     |                                                    |
|POLY 1.5           |                                           P=0.229N     |                                                    |
|POLY 6             |                                           P=0.192N     |                                                    |
|LOGISTIC REGRESSION|                                           P=0.249N     |                                                    |
|COCH-ARM / FISHERS |                                           P=0.253N     |                                                    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  38/50 (76%)              37/50 (74%)  |                                                    |
|POLY-3 ADJUSTED (b)|                  79.2%                    79.7%        |                                                    |
|TERMINAL (d)       |                  8/12 (67%)               24/27 (89%)  |                                                    |
|FIRST INCIDENCE    |                  396                      360          |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.007N**   |                                                    |
|POLY 3             |                                           P=0.584      |                                                    |
|POLY 1.5           |                                           P=0.592N     |                                                    |
|POLY 6             |                                           P=0.571      |                                                    |
|LOGISTIC REGRESSION|                                           P=0.485N     |                                                    |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)    |           0/50 (0%)                1/50 (2%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     4.8%         |           0.0%                     2.4%            |
|TERMINAL (d)       |                  0/12 (0%)                2/27 (7%)    |           0/28 (0%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  ---                      736 (T)      |           ---                      738 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.429      |                                    P=0.500         |
|POLY 3             |                                           P=0.250      |                                    P=0.500         |
|POLY 1.5           |                                           P=0.243      |                                    P=0.500         |
|POLY 6             |                                           P=0.264      |                                    P=0.501         |
|LOGISTIC REGRESSION|                                           P=0.429      |                                    P=0.500         |
|COCH-ARM / FISHERS |                                           P=0.247      |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Epidermis                                                                                                                  |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/50 (0%)                4/50 (8%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  0.0%                     9.6%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                3/27 (11%)   |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  ---                      715          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.186      |                                    (e)             |
|POLY 3             |                                           P=0.071      |                                    (e)             |
|POLY 1.5           |                                           P=0.065      |                                    (e)             |
|POLY 6             |                                           P=0.082      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.132      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.059      |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  5/50 (10%)               6/50 (12%)   |           1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  13.2%                    14.4%        |           2.4%                     0.0%            |
|TERMINAL (d)       |                  4/12 (33%)               6/27 (22%)   |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  603                      736 (T)      |           696                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.244N     |                                    P=0.489N        |
|POLY 3             |                                           P=0.562      |                                    P=0.488N        |
|POLY 1.5           |                                           P=0.530      |                                    P=0.496N        |
|POLY 6             |                                           P=0.616      |                                    P=0.481N        |
|LOGISTIC REGRESSION|                                           P=0.515N     |                                    P=0.498N        |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.500N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  4/50 (8%)                3/50 (6%)    |           9/50 (18%)               7/50 (14%)      |
|POLY-3 ADJUSTED (b)|                  10.3%                    7.1%         |           21.1%                    15.5%           |
|TERMINAL (d)       |                  1/12 (8%)                0/27 (0%)    |           5/28 (18%)               0/28 (0%)       |
|FIRST INCIDENCE    |                  396                      614          |           391                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.327N     |                                    P=0.378N        |
|POLY 3             |                                           P=0.444N     |                                    P=0.340N        |
|POLY 1.5           |                                           P=0.474N     |                                    P=0.369N        |
|POLY 6             |                                           P=0.393N     |                                    P=0.309N        |
|LOGISTIC REGRESSION|                                           P=0.526N     |                                    P=0.385N        |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.393N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     0.0%         |           2.4%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  690                      ---          |           573                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.139N     |                                    P=0.486N        |
|POLY 3             |                                           P=0.205N     |                                    P=0.492N        |
|POLY 1.5           |                                           P=0.221N     |                                    P=0.498N        |
|POLY 6             |                                           P=0.182N     |                                    P=0.486N        |
|LOGISTIC REGRESSION|                                           P=0.188N     |                                    P=0.469N        |
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    P=0.500N        |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  10/50 (20%)              2/50 (4%)    |           1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  25.6%                    4.7%         |           2.4%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  579                      265          |           731                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.004N**   |                                    P=0.507N        |
|POLY 3             |                                           P=0.007N**   |                                    P=0.487N        |
|POLY 1.5           |                                           P=0.010N*    |                                    P=0.495N        |
|POLY 6             |                                           P=0.005N**   |                                    P=0.479N        |
|LOGISTIC REGRESSION|                                           P=0.017N*    |                                    P=0.489N        |
|COCH-ARM / FISHERS |                                           P=0.014N*    |                                    P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  8/50 (16%)               4/50 (8%)    |           3/50 (6%)                4/50 (8%)       |
|POLY-3 ADJUSTED (b)|                  20.5%                    9.2%         |           7.2%                     9.2%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                1/28 (4%)       |
|FIRST INCIDENCE    |                  579                      265          |           543                      472             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.074N     |                                    P=0.520         |
|POLY 3             |                                           P=0.122N     |                                    P=0.518         |
|POLY 1.5           |                                           P=0.143N     |                                    P=0.507         |
|POLY 6             |                                           P=0.096N     |                                    P=0.528         |
|LOGISTIC REGRESSION|                                           P=0.209N     |                                    P=0.504         |
|COCH-ARM / FISHERS |                                           P=0.178N     |                                    P=0.500         |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  8/50 (16%)               1/50 (2%)    |           2/50 (4%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  20.8%                    2.4%         |           4.8%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  600                      715          |           475                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.003N**   |                                    P=0.246N        |
|POLY 3             |                                           P=0.010N*    |                                    P=0.232N        |
|POLY 1.5           |                                           P=0.012N*    |                                    P=0.237N        |
|POLY 6             |                                           P=0.007N**   |                                    P=0.227N        |
|LOGISTIC REGRESSION|                                           P=0.009N**   |                                    P=0.214N        |
|COCH-ARM / FISHERS |                                           P=0.015N*    |                                    P=0.247N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.7%                     4.8%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  0/12 (0%)                1/27 (4%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  715                      684          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.670      |                                    (e)             |
|POLY 3             |                                           P=0.527      |                                    (e)             |
|POLY 1.5           |                                           P=0.513      |                                    (e)             |
|POLY 6             |                                           P=0.551      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.575      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    (e)             |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Erosion                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)    |           1/50 (2%)                0/50 (0%)       |
|POLY-3 ADJUSTED (b)|                  5.3%                     2.4%         |           2.4%                     0.0%            |
|TERMINAL (d)       |                  1/12 (8%)                0/27 (0%)    |           0/28 (0%)                0/28 (0%)       |
|FIRST INCIDENCE    |                  603                      708          |           696                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.343N     |                                    P=0.489N        |
|POLY 3             |                                           P=0.455N     |                                    P=0.488N        |
|POLY 1.5           |                                           P=0.478N     |                                    P=0.496N        |
|POLY 6             |                                           P=0.419N     |                                    P=0.481N        |
|LOGISTIC REGRESSION|                                           P=0.485N     |                                    P=0.498N        |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)    |                                                    |
|POLY-3 ADJUSTED (b)|                  5.3%                     9.3%         |                                                    |
|TERMINAL (d)       |                  1/12 (8%)                0/27 (0%)    |                                                    |
|FIRST INCIDENCE    |                  733                      502          |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.550      |                                                    |
|POLY 3             |                                           P=0.392      |                                                    |
|POLY 1.5           |                                           P=0.364      |                                                    |
|POLY 6             |                                           P=0.439      |                                                    |
|LOGISTIC REGRESSION|                                           P=0.341      |                                                    |
|COCH-ARM / FISHERS |                                           P=0.339      |                                                    |
|=================================================================================================================================|
       Date:  09/15/97                           EXPERIMENT: 89002 TEST: 02                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -                 PENTACHLOROPHENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  10/50 (20%)              8/50 (16%)   |                                                    |
|POLY-3 ADJUSTED (b)|                  24.7%                    17.9%        |                                                    |
|TERMINAL (d)       |                  2/12 (17%)               3/27 (11%)   |                                                    |
|FIRST INCIDENCE    |                  435                      360          |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.166N     |                                                    |
|POLY 3             |                                           P=0.306N     |                                                    |
|POLY 1.5           |                                           P=0.347N     |                                                    |
|POLY 6             |                                           P=0.251N     |                                                    |
|LOGISTIC REGRESSION|                                           P=0.474N     |                                                    |
|COCH-ARM / FISHERS |                                           P=0.398N     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  0 PPM                    1000 PPM     |           0 PPM                    1000 PPM        |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  16/50 (32%)              17/50 (34%)  |           16/50 (32%)              17/50 (34%)     |
|POLY-3 ADJUSTED (b)|                  39.8%                    38.5%        |           37.8%                    38.4%           |
|TERMINAL (d)       |                  5/12 (42%)               11/27 (41%)  |           9/28 (32%)               12/28 (43%)     |
|FIRST INCIDENCE    |                  579                      360          |           620                      365             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.105N     |                                    P=0.529         |
|POLY 3             |                                           P=0.536N     |                                    P=0.563         |
|POLY 1.5           |                                           P=0.573      |                                    P=0.531         |
|POLY 6             |                                           P=0.448N     |                                    P=0.584         |
|LOGISTIC REGRESSION|                                           P=0.580      |                                    P=0.543         |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.500         |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).