National Toxicology Program

National Toxicology Program
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TDMS Study 89002-02 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 08/19/97       
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 11:02:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             Core Study                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 PPM                                                                         
                                       INCLUDE 002    0 PPM                                                                         
                                       INCLUDE 003    200 PPM                                                                       
                                       INCLUDE 004    200 PPM                                                                       
                                       INCLUDE 005    400 PPM                                                                       
                                       INCLUDE 006    400 PPM                                                                       
                                       INCLUDE 007    600 PPM                                                                       
                                       INCLUDE 008    600 PPM                                                                       
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Columbus                                     PENTACHLOROPHENOL                                   DATE: 08/19/97      
EXPERIMENT: 89002 TEST: 02                                                                                     TIME: 11:02:11      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: NO1-ES-15322                              ROUTE: DOSED FEED                                              NTP C#: C89002      
PATHOLOGIST: TOFT, J.                                                                                          CAS: 87-86-5        
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 38     CENSORED DEATHS 0    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      396   396   420   435   535   561   564   576   579   593                 |
 |      600   600   603   617   619   643   645   646   647   660                 |
 |      663   675   681   684   684   690   695   698   698   702                 |
 |      703   715   715   722   724   729   733   733                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      410   428   435   450   505   507   524   534   544   544                 |
 |      563   563   579   592   605   614   619   619   631   634                 |
 |      647   649   660   663   663   684   698   698   702   708                 |
 |      722   723   723   726                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 400 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 29     CENSORED DEATHS 0    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      360   443   482   521   527   557   561   563   572   583                 |
 |      593   593   605   617   619   620   624   640   640   645                 |
 |      648   666   676   688   698   702   711   722   729                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      213   518   544   561   605   610   614   619   620   621                 |
 |      660   684   702   707   708   708   709   712   731                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0  94.0  92.0  90.0  74.0  58.0  24.0      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0 100.0 100.0  98.0  92.0  80.0  70.0  50.0  32.0      |
 |           |                                                                    |
 |           |                                                                    |
 |400 PPM    |   100.0 100.0 100.0  98.0  98.0  94.0  90.0  74.0  58.0  42.0      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |   100.0 100.0  98.0  98.0  98.0  98.0  94.0  90.0  78.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        200 PPM      400 PPM      600 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       24.0%        32.0%        42.0%        62.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.810N     P=0.239N     P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       631.0        604.9        607.1        623.5    |
 |NATURAL DEATHS (C)      |       (15.2)       (15.8)       (15.8)       (27.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       656.2        646.8        661.2        693.2    |
 |(STANDARD ERROR)        |       (13.2)       (13.8)       (12.9)       (12.8)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 738 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      391   461   475   507   523   543   544   569   573   585                 |
 |      620   645   648   663   663   696   698   698   704   705                 |
 |      715   731                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      284   337   392   430   522   535   535   620   620   650                 |
 |      698   700   701   715   715   726   731                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 400 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      399   417   451   535   544   563   592   600   614   625                 |
 |      647   670   684   690   721   733                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 738 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      417   444   459   571   572   586   586   588   592   605                 |
 |      605   613   632   634   634   642   646   684   690   692                 |
 |      704   722                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 PENTACHLOROPHENOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 738 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   738 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0  98.0  94.0  86.0  80.0  70.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0 100.0  96.0  94.0  92.0  86.0  86.0  80.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 |400 PPM    |   100.0 100.0 100.0 100.0  96.0  94.0  90.0  84.0  78.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |   100.0 100.0 100.0 100.0  98.0  94.0  94.0  78.0  66.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        200 PPM      400 PPM      600 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.0%        66.0%        68.0%        56.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=1.000      P=0.386N     P=0.319N     P=1.000  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       607.1        583.0        592.8        605.4    |
 |NATURAL DEATHS (C)      |       (20.5)       (35.5)       (25.8)       (17.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       680.4        685.3        691.5        679.6    |
 |(STANDARD ERROR)        |       (12.9)       (15.8)       (12.6)       (12.0)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                         PENTACHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        200 PPM          = 2
                                                        400 PPM          = 3
                                                        600 PPM          = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                 4                      3     1 2
      |                                   4                      3       2  2 3          4
      |                                                                1  1 213 2   3    4 3  4  4
      |                                                                      1  2       2  331   4      4
   90 +                                                                                     31  31      44
      |                                                                                 2  2    33
      |                                                                                    2 22  131     44
      |                                                                                           313 1
P  80 +                                                                                       2  2  3 11  4      4
E     |                                                                                                          4  4
R     |                                                                                          2 2  211 1         4  4
C     |                                                                                               2 2              44
E  70 +                                                                                                 221  1
N     |                                                                                                  223 11
T     |                                                                                                   2323          4   4
      |                                                                                                      31  1          44
S  60 +                                                                                                     2 2
U     |                                                                                                       3  131
R     |                                                                                                       2  23113
V     |                                                                                                              33
I  50 +                                                                                                          2  1133
V     |                                                                                                             21133
A     |                                                                                                               223 3 3
L     |                                                                                                               112   33
   40 +                                                                                                                 2 2
      |                                                                                                                1 1
      |                                                                                                                  11
      |                                                                                                                   2  2
   30 +                                                                                                                   1 1
      |
      |                                                                                                                     11
      |
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 25 obs hidden.
                                                         PENTACHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        200 PPM          = 2
                                                        400 PPM          = 3
                                                        600 PPM          = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                            2                13  4
      |
      |                                              2        2       13  3   4  1
      |                                                       2       2   3   4 31 1
   95 +
      |                                                               2     2   34 1    1    3    4
      |                                                                     2           1  1 33
      |
   90 +                                                                                    1 21  34 4
      |
P     |                                                                                          3    3
E     |                                                                                      21   1   33  2
R  85 +
C     |                                                                                             4 43 3
E     |                                                                                           1 1 4 4323  2
N     |
T  80 +                                                                                             1     13  2       2
      |
S     |                                                                                                 441   1   3
U     |                                                                                                  4  4     3 3 22
R  75 +
V     |                                                                                                       1  1  33 2 2
I     |                                                                                                              3   3
V     |
A  70 +                                                                                                     44   1    1  22 3
L     |
      |                                                                                                      44           2 23
      |                                                                                                       4     4       22
   65 +
      |                                                                                                             4411
      |
      |
   60 +                                                                                                              4 1 1
      |
      |                                                                                                                4 14 1
      |                                                                                                                   4 11
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.