TDMS Study 89029-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98
EXPERIMENT: 89029 TEST: 06 TIME: 08:58:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG
Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: I. I. T. Research Inst MAGNETIC FIELDS (EMF) DATE: 01/06/98
EXPERIMENT: 89029 TEST: 06 TIME: 08:58:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-25351 ROUTE: MAGNETIC FIELDS NTP C#: C89029
PATHOLOGIST: PLETCHER, J CAS: ELECTROMAG
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF MAGNETIC FIELDS (EMF)
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Adrenal Cortex Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Malignant Tumors
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
Malignant Tumors
===============================================================
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 1
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 0/96 (0%) 1/99 (1%) 5/94 (5%) |0/92 (0%) 0/98 (0%) 2/99 (2%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 3.3% 0.0% 1.1% 6.1% |0.0% 0.0% 2.2% 0.0% |
|TERMINAL (d) | 3/76 (4%) 0/71 (0%) 1/84 (1%) 5/61 (8%) |0/70 (0%) 0/74 (0%) 2/79 (3%) 0/74 (0%) |
|FIRST INCIDENCE | 734 (T) --- 734 (T) 734 (T) |--- --- 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.018 * P=0.135N P=0.272N P=0.247 |P=0.631N (e) P=0.266 (e) |
|POLY 3 | P=0.032 * P=0.134N P=0.305N P=0.297 |P=0.634N (e) P=0.250 (e) |
|POLY 1.5 | P=0.034 * P=0.131N P=0.306N P=0.311 |P=0.632N (e) P=0.251 (e) |
|POLY 6 | P=0.031 * P=0.137N P=0.302N P=0.283 |P=0.634N (e) P=0.247 (e) |
|LOGISTIC REGRESSION| P=0.018 * (e) P=0.272N P=0.247 |(e) (e) P=0.266 (e) |
|COCH-ARM / FISHERS | P=0.037 * P=0.129N P=0.311N P=0.332 |P=0.625N (e) P=0.267 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/98 (1%) 0/93 (0%) 1/99 (1%) 0/91 (0%) |0/90 (0%) 3/95 (3%) 1/97 (1%) 2/97 (2%) |
|POLY-3 ADJUSTED (b)| 1.1% 0.0% 1.1% 0.0% |0.0% 3.5% 1.1% 2.3% |
|TERMINAL (d) | 1/76 (1%) 0/68 (0%) 1/84 (1%) 0/61 (0%) |0/70 (0%) 3/73 (4%) 1/79 (1%) 2/73 (3%) |
|FIRST INCIDENCE | 734 (T) --- 734 (T) --- |--- 735 (T) 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.544N P=0.522N P=0.739N P=0.544N |P=0.501 P=0.130 P=0.524 P=0.248 |
|POLY 3 | P=0.518N P=0.519N P=0.757N P=0.527N |P=0.498 P=0.124 P=0.512 P=0.245 |
|POLY 1.5 | P=0.516N P=0.515N P=0.758N P=0.522N |P=0.502 P=0.126 P=0.513 P=0.247 |
|POLY 6 | P=0.520N P=0.523N P=0.756N P=0.532N |P=0.495 P=0.123 P=0.510 P=0.243 |
|LOGISTIC REGRESSION| P=0.544N (e) P=0.739N (e) |(e) P=0.130 P=0.524 P=0.248 |
|COCH-ARM / FISHERS | P=0.512N P=0.513N P=0.749N P=0.519N |P=0.516 P=0.133 P=0.519 P=0.268 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 2
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/98 (2%) 0/93 (0%) 1/99 (1%) 0/91 (0%) |0/90 (0%) 3/95 (3%) 1/97 (1%) 2/97 (2%) |
|POLY-3 ADJUSTED (b)| 2.2% 0.0% 1.1% 0.0% |0.0% 3.5% 1.1% 2.3% |
|TERMINAL (d) | 2/76 (3%) 0/68 (0%) 1/84 (1%) 0/61 (0%) |0/70 (0%) 3/73 (4%) 1/79 (1%) 2/73 (3%) |
|FIRST INCIDENCE | 734 (T) --- 734 (T) --- |--- 735 (T) 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.377N P=0.264N P=0.465N P=0.289N |P=0.501 P=0.130 P=0.524 P=0.248 |
|POLY 3 | P=0.353N P=0.260N P=0.495N P=0.269N |P=0.498 P=0.124 P=0.512 P=0.245 |
|POLY 1.5 | P=0.351N P=0.256N P=0.496N P=0.264N |P=0.502 P=0.126 P=0.513 P=0.247 |
|POLY 6 | P=0.354N P=0.264N P=0.493N P=0.275N |P=0.495 P=0.123 P=0.510 P=0.243 |
|LOGISTIC REGRESSION| P=0.377N (e) P=0.465N (e) |(e) P=0.130 P=0.524 P=0.248 |
|COCH-ARM / FISHERS | P=0.348N P=0.262N P=0.496N P=0.268N |P=0.516 P=0.133 P=0.519 P=0.268 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Brain |
| Hamartoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/99 (0%) 0/100 (0%) 0/99 (0%) |0/99 (0%) 1/100 (1%) 2/98 (2%) 0/98 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 1.1% 2.2% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 2/79 (3%) 0/74 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- 64 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.441N P=0.500 P=0.266 (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.451N P=0.503 P=0.240 (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.452N P=0.503 P=0.238 (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.449N P=0.503 P=0.240 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.391N (e) P=0.266 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.448N P=0.503 P=0.246 (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 3
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 12/100 (12%) 16/100 (16%) 16/100 (16%) 12/100 (12%)|10/100 (10%) 8/100 (8%) 14/100 (14%) 12/100 (12%) |
|POLY-3 ADJUSTED (b)| 13.0% 17.8% 16.9% 13.9% |11.0% 8.8% 15.3% 13.4% |
|TERMINAL (d) | 11/76 (15%) 12/72 (17%) 11/84 (13%) 9/62 (15%) |7/70 (10%) 6/74 (8%) 13/79 (17%) 12/74 (16%) |
|FIRST INCIDENCE | 716 589 585 483 |625 692 692 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.555 P=0.226 P=0.362 P=0.392 |P=0.333 P=0.367N P=0.350 P=0.458 |
|POLY 3 | P=0.413N P=0.240 P=0.290 P=0.517 |P=0.309 P=0.406N P=0.258 P=0.399 |
|POLY 1.5 | P=0.383N P=0.252 P=0.281 P=0.544 |P=0.310 P=0.406N P=0.255 P=0.399 |
|POLY 6 | P=0.449N P=0.229 P=0.306 P=0.486 |P=0.310 P=0.408N P=0.256 P=0.399 |
|LOGISTIC REGRESSION| P=0.401N P=0.220 P=0.274 P=0.486 |P=0.321 P=0.402N P=0.263 P=0.410 |
|COCH-ARM / FISHERS | P=0.338N P=0.271 P=0.271 P=0.586N |P=0.322 P=0.403N P=0.257 P=0.411 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 12/100 (12%) 18/100 (18%) 16/100 (16%) 12/100 (12%)|12/100 (12%) 8/100 (8%) 14/100 (14%) 12/100 (12%) |
|POLY-3 ADJUSTED (b)| 13.0% 19.9% 16.9% 13.9% |13.2% 8.8% 15.3% 13.4% |
|TERMINAL (d) | 11/76 (15%) 13/72 (18%) 11/84 (13%) 9/62 (15%) |9/70 (13%) 6/74 (8%) 13/79 (17%) 12/74 (16%) |
|FIRST INCIDENCE | 716 485 585 483 |625 692 692 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.480N P=0.130 P=0.362 P=0.392 |P=0.424 P=0.211N P=0.528 P=0.536N |
|POLY 3 | P=0.342N P=0.142 P=0.290 P=0.517 |P=0.398 P=0.242N P=0.419 P=0.574 |
|POLY 1.5 | P=0.312N P=0.149 P=0.281 P=0.544 |P=0.398 P=0.242N P=0.415 P=0.574 |
|POLY 6 | P=0.378N P=0.135 P=0.306 P=0.486 |P=0.399 P=0.243N P=0.418 P=0.575 |
|LOGISTIC REGRESSION| P=0.309N P=0.138 P=0.274 P=0.486 |P=0.411 P=0.239N P=0.425 P=0.586N |
|COCH-ARM / FISHERS | P=0.268N P=0.161 P=0.271 P=0.586N |P=0.411 P=0.240N P=0.417 P=0.586N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 4
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Heart |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 2/100 (2%) 0/100 (0%) 0/99 (0%) |0/98 (0%) 0/100 (0%) 0/100 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/76 (0%) 2/72 (3%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | --- 734 (T) --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.404N P=0.227 (e) (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.385N P=0.229 (e) (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.379N P=0.233 (e) (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.393N P=0.225 (e) (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.227 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.369N P=0.249 (e) (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Intestine Small: Duodenum |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 2/100 (2%) 1/100 (1%) 0/100 (0%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% 1.1% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/76 (0%) 1/72 (1%) 1/84 (1%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | --- 725 734 (T) --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.380N P=0.228 P=0.520 (e) |(e) (e) (e) (e) |
|POLY 3 | P=0.359N P=0.229 P=0.501 (e) |(e) (e) (e) (e) |
|POLY 1.5 | P=0.351N P=0.233 P=0.501 (e) |(e) (e) (e) (e) |
|POLY 6 | P=0.369N P=0.226 P=0.503 (e) |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.365N P=0.223 P=0.520 (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.338N P=0.249 P=0.500 (e) |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 5
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 1/100 (1%) 3/100 (3%) 1/100 (1%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.1% 1.1% 3.2% 1.2% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 1/72 (1%) 3/84 (4%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | 734 (T) 734 (T) 734 (T) 500 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.649N P=0.749 P=0.343 P=0.733 |(e) (e) (e) (e) |
|POLY 3 | P=0.602N P=0.751 P=0.309 P=0.745 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.593N P=0.755 P=0.308 P=0.751 |(e) (e) (e) (e) |
|POLY 6 | P=0.612N P=0.747 P=0.312 P=0.738 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.568N P=0.749 P=0.343 P=0.694N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.579N P=0.751N P=0.311 P=0.751N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 3/100 (3%) 4/100 (4%) 2/100 (2%) |0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.1% 3.4% 4.3% 2.3% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 2/72 (3%) 4/84 (5%) 1/62 (2%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | 734 (T) 725 734 (T) 500 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.600 P=0.289 P=0.214 P=0.448 |(e) (e) (e) (e) |
|POLY 3 | P=0.595N P=0.292 P=0.184 P=0.476 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.582N P=0.298 P=0.183 P=0.485 |(e) (e) (e) (e) |
|POLY 6 | P=0.610N P=0.286 P=0.187 P=0.465 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.578N P=0.282 P=0.214 P=0.562 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.562N P=0.311 P=0.184 P=0.500 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 6
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 3/99 (3%) 1/98 (1%) 0/97 (0%) |2/87 (2%) 0/95 (0%) 7/94 (7%) 2/94 (2%) |
|POLY-3 ADJUSTED (b)| 1.1% 3.4% 1.1% 0.0% |2.4% 0.0% 8.0% 2.3% |
|TERMINAL (d) | 1/76 (1%) 2/72 (3%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 0/74 (0%) 6/79 (8%) 2/74 (3%) |
|FIRST INCIDENCE | 734 (T) 722 585 --- |542 --- 694 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.192N P=0.290 P=0.749N P=0.541N |P=0.594 P=0.236N P=0.111 P=0.680N |
|POLY 3 | P=0.181N P=0.292 P=0.759N P=0.517N |P=0.609 P=0.228N P=0.101 P=0.672N |
|POLY 1.5 | P=0.176N P=0.298 P=0.760 P=0.512N |P=0.608 P=0.225N P=0.102 P=0.670N |
|POLY 6 | P=0.188N P=0.286 P=0.756N P=0.523N |P=0.610 P=0.230N P=0.098 P=0.675N |
|LOGISTIC REGRESSION| P=0.165N P=0.282 P=0.757 (e) |P=0.605 P=0.185N P=0.106 P=0.655N |
|COCH-ARM / FISHERS | P=0.167N P=0.311 P=0.749 P=0.505N |P=0.605 P=0.227N P=0.104 P=0.660N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/99 (3%) 3/99 (3%) 2/98 (2%) 1/97 (1%) |2/87 (2%) 0/95 (0%) 7/94 (7%) 2/94 (2%) |
|POLY-3 ADJUSTED (b)| 3.2% 3.4% 2.2% 1.2% |2.4% 0.0% 8.0% 2.3% |
|TERMINAL (d) | 2/76 (3%) 2/72 (3%) 1/84 (1%) 1/62 (2%) |1/70 (1%) 0/74 (0%) 6/79 (8%) 2/74 (3%) |
|FIRST INCIDENCE | 534 722 585 734 (T) |542 --- 694 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.288N P=0.638 P=0.473N P=0.371N |P=0.594 P=0.236N P=0.111 P=0.680N |
|POLY 3 | P=0.258N P=0.638 P=0.501N P=0.340N |P=0.609 P=0.228N P=0.101 P=0.672N |
|POLY 1.5 | P=0.250N P=0.647 P=0.503N P=0.329N |P=0.608 P=0.225N P=0.102 P=0.670N |
|POLY 6 | P=0.268N P=0.629 P=0.496N P=0.352N |P=0.610 P=0.230N P=0.098 P=0.675N |
|LOGISTIC REGRESSION| P=0.227N P=0.653N P=0.510N P=0.287N |P=0.605 P=0.185N P=0.106 P=0.655N |
|COCH-ARM / FISHERS | P=0.238N P=0.659N P=0.505N P=0.318N |P=0.605 P=0.227N P=0.104 P=0.660N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 7
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 2/98 (2%) 0/99 (0%) 0/96 (0%) |0/92 (0%) 0/96 (0%) 0/98 (0%) 0/98 (0%) |
|POLY-3 ADJUSTED (b)| 1.1% 2.3% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 2/72 (3%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | 734 (T) 734 (T) --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.274N P=0.481 P=0.480N P=0.541N |(e) (e) (e) (e) |
|POLY 3 | P=0.257N P=0.484 P=0.499N P=0.518N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.253N P=0.489 P=0.500N P=0.513N |(e) (e) (e) (e) |
|POLY 6 | P=0.262N P=0.478 P=0.497N P=0.523N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.274N P=0.481 (e) (e) |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.247N P=0.496 P=0.500N P=0.508N |(e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 2/98 (2%) 0/99 (0%) 0/96 (0%) |0/92 (0%) 0/96 (0%) 0/98 (0%) 0/98 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 2.3% 0.0% 0.0% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 2/72 (3%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | 534 734 (T) --- --- |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.189N P=0.676 P=0.229N P=0.272N |(e) (e) (e) (e) |
|POLY 3 | P=0.177N P=0.673 P=0.239N P=0.260N |(e) (e) (e) (e) |
|POLY 1.5 | P=0.174N P=0.679 P=0.239N P=0.254N |(e) (e) (e) (e) |
|POLY 6 | P=0.181N P=0.666 P=0.238N P=0.268N |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.160N P=0.678N P=0.237N P=0.194N |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.169N P=0.686 P=0.249N P=0.256N |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 8
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 2/100 (2%) 3/100 (3%) 5/98 (5%) |1/98 (1%) 1/97 (1%) 1/98 (1%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 4.3% 2.2% 3.2% 5.9% |1.1% 1.1% 1.1% 0.0% |
|TERMINAL (d) | 1/76 (1%) 1/72 (1%) 1/84 (1%) 3/62 (5%) |0/70 (0%) 1/74 (1%) 1/79 (1%) 0/74 (0%) |
|FIRST INCIDENCE | 582 624 585 518 |723 735 (T) 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.187 P=0.369N P=0.475N P=0.407 |P=0.334N P=0.753N P=0.744N P=0.497N |
|POLY 3 | P=0.222 P=0.361N P=0.498N P=0.446 |P=0.337N P=0.758 P=0.759N P=0.500N |
|POLY 1.5 | P=0.231 P=0.352N P=0.499N P=0.463 |P=0.337N P=0.758 P=0.759N P=0.500N |
|POLY 6 | P=0.212 P=0.371N P=0.495N P=0.426 |P=0.337N P=0.758 P=0.759N P=0.500N |
|LOGISTIC REGRESSION| P=0.291 P=0.300N P=0.503N P=0.552 |P=0.335N P=0.760 P=0.760N P=0.500N |
|COCH-ARM / FISHERS | P=0.244 P=0.341N P=0.500N P=0.487 |P=0.333N P=0.749 P=0.751N P=0.497N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 2/100 (2%) 1/100 (1%) 4/98 (4%) |0/98 (0%) 0/97 (0%) 0/98 (0%) 0/99 (0%) |
|POLY-3 ADJUSTED (b)| 2.2% 2.3% 1.1% 4.7% |0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 2/72 (3%) 1/84 (1%) 3/62 (5%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | 731 734 (T) 734 (T) 716 |--- --- --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.116 P=0.672 P=0.467N P=0.256 |(e) (e) (e) (e) |
|POLY 3 | P=0.160 P=0.678 P=0.498N P=0.300 |(e) (e) (e) (e) |
|POLY 1.5 | P=0.167 P=0.684 P=0.499N P=0.312 |(e) (e) (e) (e) |
|POLY 6 | P=0.153 P=0.671 P=0.495N P=0.286 |(e) (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.132 P=0.671 P=0.480N P=0.269 |(e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.176 P=0.689N P=0.500N P=0.332 |(e) (e) (e) (e) |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 9
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/100 (30%) 26/100 (26%) 32/100 (32%) 21/98 (21%) |17/98 (17%) 10/97 (10%) 20/98 (20%) 18/99 (18%) |
|POLY-3 ADJUSTED (b)| 32.3% 28.9% 34.0% 24.4% |19.0% 11.3% 22.0% 20.1% |
|TERMINAL (d) | 28/76 (37%) 22/72 (31%) 30/84 (36%) 15/62 (24%) |16/70 (23%) 9/74 (12%) 19/79 (24%) 16/74 (22%) |
|FIRST INCIDENCE | 646 560 562 500 |667 723 578 690 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.318N P=0.410N P=0.508N P=0.304N |P=0.258 P=0.080N P=0.508 P=0.569 |
|POLY 3 | P=0.148N P=0.367N P=0.460 P=0.156N |P=0.246 P=0.111N P=0.371 P=0.498 |
|POLY 1.5 | P=0.130N P=0.347N P=0.450 P=0.136N |P=0.248 P=0.112N P=0.367 P=0.498 |
|POLY 6 | P=0.174N P=0.388N P=0.479 P=0.181N |P=0.248 P=0.110N P=0.369 P=0.501 |
|LOGISTIC REGRESSION| P=0.171N P=0.411N P=0.461 P=0.191N |P=0.251 P=0.104N P=0.363 P=0.511 |
|COCH-ARM / FISHERS | P=0.108N P=0.318N P=0.439 P=0.112N |P=0.264 P=0.112N P=0.358 P=0.513 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/100 (19%) 14/100 (14%) 20/100 (20%) 15/98 (15%) |6/98 (6%) 5/97 (5%) 7/98 (7%) 6/99 (6%) |
|POLY-3 ADJUSTED (b)| 19.8% 15.3% 21.2% 17.1% |6.7% 5.6% 7.7% 6.6% |
|TERMINAL (d) | 8/76 (11%) 6/72 (8%) 17/84 (20%) 9/62 (15%) |4/70 (6%) 2/74 (3%) 5/79 (6%) 4/74 (5%) |
|FIRST INCIDENCE | 520 542 527 480 |691 545 578 183 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.519 P=0.296N P=0.546N P=0.473N |P=0.546 P=0.482N P=0.561 P=0.592N |
|POLY 3 | P=0.472N P=0.268N P=0.477 P=0.392N |P=0.554 P=0.502N P=0.511 P=0.607N |
|POLY 1.5 | P=0.442N P=0.250N P=0.486 P=0.356N |P=0.553 P=0.505N P=0.507 P=0.609N |
|POLY 6 | P=0.513N P=0.289N P=0.468 P=0.438N |P=0.554 P=0.499N P=0.512 P=0.605N |
|LOGISTIC REGRESSION| P=0.321N P=0.150N P=0.495 P=0.191N |P=0.574 P=0.507N P=0.501 P=0.581N |
|COCH-ARM / FISHERS | P=0.402N P=0.223N P=0.500 P=0.309N |P=0.553 P=0.507N P=0.500 P=0.609N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 10
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/100 (21%) 16/100 (16%) 21/100 (21%) 19/98 (19%) |6/98 (6%) 5/97 (5%) 7/98 (7%) 6/99 (6%) |
|POLY-3 ADJUSTED (b)| 21.9% 17.5% 22.2% 21.7% |6.7% 5.6% 7.7% 6.6% |
|TERMINAL (d) | 9/76 (12%) 8/72 (11%) 18/84 (21%) 12/62 (19%) |4/70 (6%) 2/74 (3%) 5/79 (6%) 4/74 (5%) |
|FIRST INCIDENCE | 520 542 527 480 |691 545 578 183 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.310 P=0.312N P=0.470N P=0.487 |P=0.546 P=0.482N P=0.561 P=0.592N |
|POLY 3 | P=0.428 P=0.283N P=0.545 P=0.557N |P=0.554 P=0.502N P=0.511 P=0.607N |
|POLY 1.5 | P=0.460 P=0.262N P=0.554 P=0.516N |P=0.553 P=0.505N P=0.507 P=0.609N |
|POLY 6 | P=0.386 P=0.306N P=0.536 P=0.534 |P=0.554 P=0.499N P=0.512 P=0.605N |
|LOGISTIC REGRESSION| P=0.529N P=0.170N P=0.565 P=0.353N |P=0.574 P=0.507N P=0.501 P=0.581N |
|COCH-ARM / FISHERS | P=0.504 P=0.233N P=0.569N P=0.458N |P=0.553 P=0.507N P=0.500 P=0.609N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 46/100 (46%) 37/100 (37%) 45/100 (45%) 35/98 (36%) |22/98 (22%) 13/97 (13%) 24/98 (24%) 23/99 (23%) |
|POLY-3 ADJUSTED (b)| 47.8% 39.9% 47.2% 39.5% |24.5% 14.5% 26.4% 25.2% |
|TERMINAL (d) | 34/76 (45%) 26/72 (36%) 40/84 (48%) 24/62 (39%) |19/70 (27%) 10/74 (14%) 22/79 (28%) 19/74 (26%) |
|FIRST INCIDENCE | 520 542 527 480 |667 545 578 183 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.502N P=0.231N P=0.310N P=0.354N |P=0.215 P=0.052N P=0.537N P=0.563N |
|POLY 3 | P=0.242N P=0.169N P=0.522N P=0.157N |P=0.217 P=0.067N P=0.451 P=0.522 |
|POLY 1.5 | P=0.205N P=0.150N P=0.513N P=0.126N |P=0.216 P=0.069N P=0.445 P=0.518 |
|POLY 6 | P=0.297N P=0.190N P=0.528N P=0.204N |P=0.217 P=0.065N P=0.448 P=0.526 |
|LOGISTIC REGRESSION| P=0.187N P=0.129N P=0.498N P=0.103N |P=0.206 P=0.071N P=0.443 P=0.504 |
|COCH-ARM / FISHERS | P=0.164N P=0.125N P=0.500N P=0.092N |P=0.219 P=0.072N P=0.433 P=0.516 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 11
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, |
| or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 47/100 (47%) 38/100 (38%) 46/100 (46%) 38/98 (39%) |22/98 (22%) 13/97 (13%) 24/98 (24%) 23/99 (23%) |
|POLY-3 ADJUSTED (b)| 48.8% 41.0% 48.2% 42.8% |24.5% 14.5% 26.4% 25.2% |
|TERMINAL (d) | 34/76 (45%) 27/72 (38%) 41/84 (49%) 26/62 (42%) |19/70 (27%) 10/74 (14%) 22/79 (28%) 19/74 (26%) |
|FIRST INCIDENCE | 520 542 527 480 |667 545 578 183 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.424 P=0.235N P=0.307N P=0.478N |P=0.215 P=0.052N P=0.537N P=0.563N |
|POLY 3 | P=0.371N P=0.171N P=0.522N P=0.247N |P=0.217 P=0.067N P=0.451 P=0.522 |
|POLY 1.5 | P=0.324N P=0.152N P=0.514N P=0.203N |P=0.216 P=0.069N P=0.445 P=0.518 |
|POLY 6 | P=0.437N P=0.193N P=0.529N P=0.310N |P=0.217 P=0.065N P=0.448 P=0.526 |
|LOGISTIC REGRESSION| P=0.305N P=0.133N P=0.497N P=0.177N |P=0.206 P=0.071N P=0.443 P=0.504 |
|COCH-ARM / FISHERS | P=0.267N P=0.126N P=0.500N P=0.153N |P=0.219 P=0.072N P=0.433 P=0.516 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/100 (26%) 11/99 (11%) 9/100 (9%) 16/99 (16%) |9/95 (9%) 6/100 (6%) 0/99 (0%) 5/99 (5%) |
|POLY-3 ADJUSTED (b)| 28.0% 12.5% 9.6% 18.0% |10.2% 6.6% 0.0% 5.6% |
|TERMINAL (d) | 22/76 (29%) 10/72 (14%) 7/84 (8%) 7/62 (11%) |7/70 (10%) 4/74 (5%) 0/79 (0%) 4/74 (5%) |
|FIRST INCIDENCE | 683 722 585 518 |551 603 --- 566 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.430 P=0.009N** P<0.001N** P=0.187N |P=0.363N P=0.270N P=0.002N** P=0.181N |
|POLY 3 | P=0.470N P=0.007N** P<0.001N** P=0.077N |P=0.363N P=0.271N P=0.002N** P=0.190N |
|POLY 1.5 | P=0.464N P=0.006N** P<0.001N** P=0.071N |P=0.365N P=0.269N P=0.002N** P=0.190N |
|POLY 6 | P=0.475N P=0.009N** P<0.001N** P=0.084N |P=0.360N P=0.274N P=0.002N** P=0.189N |
|LOGISTIC REGRESSION| P=0.500N P=0.009N** P<0.001N** P=0.074N |P=0.362N P=0.264N P=0.003N** P=0.184N |
|COCH-ARM / FISHERS | P=0.454N P=0.006N** P<0.001N** P=0.063N |P=0.360N P=0.261N P<0.001N** P=0.181N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 12
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 11/99 (11%) 12/100 (12%) 10/99 (10%) |2/95 (2%) 6/100 (6%) 2/99 (2%) 2/99 (2%) |
|POLY-3 ADJUSTED (b)| 8.6% 12.4% 12.8% 11.5% |2.3% 6.6% 2.2% 2.2% |
|TERMINAL (d) | 7/76 (9%) 9/72 (13%) 11/84 (13%) 5/62 (8%) |0/70 (0%) 4/74 (5%) 2/79 (3%) 1/74 (1%) |
|FIRST INCIDENCE | 715 612 430 448 |701 496 735 (T) 687 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.359 P=0.272 P=0.313 P=0.267 |P=0.283N P=0.152 P=0.671N P=0.688N |
|POLY 3 | P=0.495 P=0.280 P=0.249 P=0.351 |P=0.287N P=0.154 P=0.678N P=0.684N |
|POLY 1.5 | P=0.514 P=0.290 P=0.246 P=0.369 |P=0.287N P=0.154 P=0.678N P=0.684N |
|POLY 6 | P=0.471 P=0.269 P=0.256 P=0.331 |P=0.286N P=0.153 P=0.681N P=0.684N |
|LOGISTIC REGRESSION| P=0.517 P=0.263 P=0.242 P=0.385 |P=0.275N P=0.166 P=0.679N P=0.682N |
|COCH-ARM / FISHERS | P=0.541 P=0.307 P=0.240 P=0.394 |P=0.280N P=0.157 P=0.674N P=0.674N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/100 (30%) 21/99 (21%) 19/100 (19%) 25/99 (25%) |11/95 (12%) 11/100 (11%) 2/99 (2%) 7/99 (7%) |
|POLY-3 ADJUSTED (b)| 32.2% 23.7% 20.1% 27.7% |12.5% 11.9% 2.2% 7.8% |
|TERMINAL (d) | 25/76 (33%) 19/72 (26%) 16/84 (19%) 11/62 (18%) |7/70 (10%) 7/74 (10%) 2/79 (3%) 5/74 (7%) |
|FIRST INCIDENCE | 683 612 430 448 |551 496 735 (T) 566 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.232 P=0.144N P=0.025N* P=0.542N |P=0.245N P=0.553N P=0.008N** P=0.209N |
|POLY 3 | P=0.495 P=0.130N P=0.041N* P=0.302N |P=0.246N P=0.544N P=0.008N** P=0.213N |
|POLY 1.5 | P=0.497 P=0.119N P=0.044N* P=0.293N |P=0.246N P=0.544N P=0.008N** P=0.213N |
|POLY 6 | P=0.497 P=0.146N P=0.037N* P=0.310N |P=0.243N P=0.545N P=0.009N** P=0.213N |
|LOGISTIC REGRESSION| P=0.460 P=0.150N P=0.047N* P=0.291N |P=0.237N P=0.531N P=0.009N** P=0.207N |
|COCH-ARM / FISHERS | P=0.501 P=0.104N P=0.050N P=0.278N |P=0.239N P=0.539N P=0.007N** P=0.202N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 13
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Mesentery |
| Liposarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |0/100 (0%) 3/100 (3%) 1/100 (1%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |0.0% 3.3% 1.1% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |0/70 (0%) 3/74 (4%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | --- --- --- --- |--- 735 (T) 659 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.232N P=0.132 P=0.495 (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.235N P=0.121 P=0.502 (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.235N P=0.121 P=0.501 (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.234N P=0.121 P=0.503 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.235N P=0.132 P=0.507 (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.234N P=0.123 P=0.500 (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |3/79 (4%) 3/91 (3%) 2/95 (2%) 2/94 (2%) |
|POLY-3 ADJUSTED (b)| |4.0% 3.6% 2.3% 2.4% |
|TERMINAL (d) | |3/65 (5%) 2/70 (3%) 2/78 (3%) 2/72 (3%) |
|FIRST INCIDENCE | |735 (T) 461 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.418N P=0.630N P=0.418N P=0.454N |
|POLY 3 | |P=0.407N P=0.605N P=0.424N P=0.439N |
|POLY 1.5 | |P=0.405N P=0.602N P=0.422N P=0.435N |
|POLY 6 | |P=0.407N P=0.609N P=0.430N P=0.442N |
|LOGISTIC REGRESSION| |P=0.396N P=0.581N P=0.418N P=0.454N |
|COCH-ARM / FISHERS | |P=0.395N P=0.590N P=0.413N P=0.418N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 14
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | |2/79 (3%) 3/91 (3%) 1/95 (1%) 0/94 (0%) |
|POLY-3 ADJUSTED (b)| |2.7% 3.6% 1.1% 0.0% |
|TERMINAL (d) | |2/65 (3%) 3/70 (4%) 1/78 (1%) 0/72 (0%) |
|FIRST INCIDENCE | |735 (T) 735 (T) 735 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | |P=0.107N P=0.534 P=0.437N P=0.217N |
|POLY 3 | |P=0.106N P=0.550 P=0.442N P=0.208N |
|POLY 1.5 | |P=0.105N P=0.554 P=0.440N P=0.207N |
|POLY 6 | |P=0.106N P=0.545 P=0.446N P=0.210N |
|LOGISTIC REGRESSION| |P=0.107N P=0.534 P=0.437N (e) |
|COCH-ARM / FISHERS | |P=0.102N P=0.567 P=0.431N P=0.207N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/83 (0%) 1/84 (1%) 1/82 (1%) 0/84 (0%) |17/83 (20%) 17/92 (18%) 20/87 (23%) 21/89 (24%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.3% 1.3% 0.0% |21.9% 20.1% 24.1% 25.8% |
|TERMINAL (d) | 0/66 (0%) 1/64 (2%) 0/72 (0%) 0/57 (0%) |16/67 (24%) 15/71 (21%) 20/76 (26%) 20/71 (28%) |
|FIRST INCIDENCE | --- 734 (T) 701 --- |625 698 735 (T) 730 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.534N P=0.494 P=0.509 (e) |P=0.269 P=0.508N P=0.520 P=0.360 |
|POLY 3 | P=0.515N P=0.494 P=0.500 (e) |P=0.258 P=0.465N P=0.445 P=0.352 |
|POLY 1.5 | P=0.508N P=0.497 P=0.499 (e) |P=0.261 P=0.460N P=0.437 P=0.356 |
|POLY 6 | P=0.522N P=0.491 P=0.502 (e) |P=0.253 P=0.470N P=0.448 P=0.346 |
|LOGISTIC REGRESSION| P=0.507N P=0.494 P=0.496 (e) |P=0.259 P=0.467N P=0.463 P=0.356 |
|COCH-ARM / FISHERS | P=0.499N P=0.503 P=0.497 (e) |P=0.279 P=0.442N P=0.417 P=0.380 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 15
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skeletal Muscle |
| Rhabdomyosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 1/100 (1%) |3/100 (3%) 1/100 (1%) 0/100 (0%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 1.2% |3.3% 1.1% 0.0% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |2/70 (3%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | --- --- --- 703 |707 713 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.210 (e) (e) P=0.472 |P=0.163N P=0.296N P=0.110N P=0.117N |
|POLY 3 | P=0.225 (e) (e) P=0.485 |P=0.165N P=0.307N P=0.120N P=0.123N |
|POLY 1.5 | P=0.228 (e) (e) P=0.491 |P=0.165N P=0.308N P=0.121N P=0.123N |
|POLY 6 | P=0.221 (e) (e) P=0.478 |P=0.165N P=0.307N P=0.120N P=0.122N |
|LOGISTIC REGRESSION| P=0.231 (e) (e) P=0.496 |P=0.165N P=0.307N P=0.121N P=0.123N |
|COCH-ARM / FISHERS | P=0.233 (e) (e) P=0.500 |P=0.165N P=0.311N P=0.123N P=0.123N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, |
| or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |4/100 (4%) 5/100 (5%) 2/100 (2%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |4.4% 5.4% 2.2% 3.3% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 2/74 (3%) 1/79 (1%) 0/74 (0%) |
|FIRST INCIDENCE | --- --- --- --- |625 461 513 684 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.398N P=0.509 P=0.325N P=0.502N |
|POLY 3 | (e) (e) (e) (e) |P=0.404N P=0.506 P=0.336N P=0.504N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.403N P=0.504 P=0.339N P=0.505N |
|POLY 6 | (e) (e) (e) (e) |P=0.402N P=0.508 P=0.337N P=0.502N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.379N P=0.515 P=0.328N P=0.496N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.397N P=0.500 P=0.341N P=0.500N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 16
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |4/100 (4%) 5/100 (5%) 2/100 (2%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |4.4% 5.4% 2.2% 3.3% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 2/74 (3%) 1/79 (1%) 0/74 (0%) |
|FIRST INCIDENCE | --- --- --- --- |625 461 513 684 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.398N P=0.509 P=0.325N P=0.502N |
|POLY 3 | (e) (e) (e) (e) |P=0.404N P=0.506 P=0.336N P=0.504N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.403N P=0.504 P=0.339N P=0.505N |
|POLY 6 | (e) (e) (e) (e) |P=0.402N P=0.508 P=0.337N P=0.502N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.379N P=0.515 P=0.328N P=0.496N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.397N P=0.500 P=0.341N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skin |
| Neurofibrosarcoma, Neurofibroma, or Schwannoma (benign, |
| malignant or NOS) |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/100 (1%) 1/100 (1%) 1/100 (1%) |2/100 (2%) 1/100 (1%) 4/100 (4%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 1.1% 1.1% 1.2% |2.2% 1.1% 4.3% 1.1% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 0/74 (0%) 2/79 (3%) 0/74 (0%) |
|FIRST INCIDENCE | --- 542 449 604 |608 672 578 576 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.542 P=0.498 P=0.500 P=0.482 |P=0.431N P=0.495N P=0.374 P=0.497N |
|POLY 3 | P=0.534 P=0.493 P=0.503 P=0.486 |P=0.433N P=0.501N P=0.346 P=0.502N |
|POLY 1.5 | P=0.542 P=0.496 P=0.502 P=0.491 |P=0.434N P=0.501N P=0.342 P=0.503N |
|POLY 6 | P=0.524 P=0.490 P=0.505 P=0.480 |P=0.430N P=0.501N P=0.348 P=0.500N |
|LOGISTIC REGRESSION| P=0.694N P=0.556 P=0.442 P=0.575 |P=0.416N P=0.495N P=0.351 P=0.476N |
|COCH-ARM / FISHERS | P=0.556 P=0.500 P=0.500 P=0.500 |P=0.430N P=0.500N P=0.341 P=0.500N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 17
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skin |
| Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 0/100 (0%) 0/100 (0%) |4/100 (4%) 5/100 (5%) 2/100 (2%) 3/100 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |4.4% 5.4% 2.2% 3.3% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 2/74 (3%) 1/79 (1%) 0/74 (0%) |
|FIRST INCIDENCE | --- --- --- --- |625 461 513 684 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.398N P=0.509 P=0.325N P=0.502N |
|POLY 3 | (e) (e) (e) (e) |P=0.404N P=0.506 P=0.336N P=0.504N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.403N P=0.504 P=0.339N P=0.505N |
|POLY 6 | (e) (e) (e) (e) |P=0.402N P=0.508 P=0.337N P=0.502N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.379N P=0.515 P=0.328N P=0.496N |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.397N P=0.500 P=0.341N P=0.500N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Skin |
| Schwannoma Malignant |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 1/100 (1%) 1/100 (1%) |2/100 (2%) 1/100 (1%) 4/100 (4%) 1/100 (1%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 1.1% 1.2% |2.2% 1.1% 4.3% 1.1% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 0/84 (0%) 0/62 (0%) |1/70 (1%) 0/74 (0%) 2/79 (3%) 0/74 (0%) |
|FIRST INCIDENCE | --- --- 449 604 |608 672 578 576 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.357 (e) P=0.500 P=0.482 |P=0.431N P=0.495N P=0.374 P=0.497N |
|POLY 3 | P=0.351 (e) P=0.503 P=0.486 |P=0.433N P=0.501N P=0.346 P=0.502N |
|POLY 1.5 | P=0.357 (e) P=0.502 P=0.491 |P=0.434N P=0.501N P=0.342 P=0.503N |
|POLY 6 | P=0.344 (e) P=0.505 P=0.480 |P=0.430N P=0.501N P=0.348 P=0.500N |
|LOGISTIC REGRESSION| P=0.512 (e) P=0.442 P=0.575 |P=0.416N P=0.495N P=0.351 P=0.476N |
|COCH-ARM / FISHERS | P=0.366 (e) P=0.500 P=0.500 |P=0.430N P=0.500N P=0.341 P=0.500N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 18
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/99 (2%) 5/98 (5%) 0/98 (0%) 3/93 (3%) |0/91 (0%) 0/93 (0%) 0/95 (0%) 1/93 (1%) |
|POLY-3 ADJUSTED (b)| 2.2% 5.6% 0.0% 3.7% |0.0% 0.0% 0.0% 1.1% |
|TERMINAL (d) | 2/76 (3%) 3/72 (4%) 0/84 (0%) 2/62 (3%) |0/70 (0%) 0/74 (0%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | 734 (T) 400 --- 726 |--- --- --- 715 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.543 P=0.207 P=0.217N P=0.411 |P=0.236 (e) (e) P=0.505 |
|POLY 3 | P=0.567 P=0.208 P=0.238N P=0.445 |P=0.236 (e) (e) P=0.505 |
|POLY 1.5 | P=0.577 P=0.212 P=0.239N P=0.456 |P=0.235 (e) (e) P=0.504 |
|POLY 6 | P=0.556 P=0.204 P=0.236N P=0.434 |P=0.237 (e) (e) P=0.506 |
|LOGISTIC REGRESSION| P=0.614N P=0.263 (e) P=0.419 |P=0.234 (e) (e) P=0.504 |
|COCH-ARM / FISHERS | P=0.593 P=0.218 P=0.251N P=0.470 |P=0.234 (e) (e) P=0.505 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/99 (1%) 1/98 (1%) 2/100 (2%) 1/96 (1%) | |
|POLY-3 ADJUSTED (b)| 1.1% 1.1% 2.1% 1.2% | |
|TERMINAL (d) | 1/76 (1%) 1/72 (1%) 1/84 (1%) 1/62 (2%) | |
|FIRST INCIDENCE | 734 (T) 734 (T) 701 734 (T) | |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.658 P=0.749 P=0.529 P=0.715 | |
|POLY 3 | P=0.656N P=0.749 P=0.505 P=0.739 | |
|POLY 1.5 | P=0.649N P=0.753 P=0.504 P=0.745 | |
|POLY 6 | P=0.664N P=0.745 P=0.507 P=0.732 | |
|LOGISTIC REGRESSION| P=0.669N P=0.749 P=0.505 P=0.715 | |
|COCH-ARM / FISHERS | P=0.639N P=0.749 P=0.504 P=0.744 | |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 19
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma: Benign, Malignant, NOS |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/69 (0%) 0/68 (0%) 0/63 (0%) 0/68 (0%) |1/78 (1%) 2/92 (2%) 0/84 (0%) 0/75 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% |1.4% 2.4% 0.0% 0.0% |
|TERMINAL (d) | 0/54 (0%) 0/51 (0%) 0/58 (0%) 0/41 (0%) |1/62 (2%) 1/69 (1%) 0/70 (0%) 0/60 (0%) |
|FIRST INCIDENCE | --- --- --- --- |735 (T) 672 --- --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.252N P=0.525 P=0.476N P=0.507N |
|POLY 3 | (e) (e) (e) (e) |P=0.266N P=0.548 P=0.488N P=0.512N |
|POLY 1.5 | (e) (e) (e) (e) |P=0.266N P=0.551 P=0.487N P=0.511N |
|POLY 6 | (e) (e) (e) (e) |P=0.267N P=0.544 P=0.490N P=0.513N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.265N P=0.554 (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.264N P=0.562 P=0.481N P=0.510N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/100 (0%) 1/100 (1%) 0/100 (0%) |0/100 (0%) 2/100 (2%) 1/100 (1%) 2/100 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 1.1% 0.0% |0.0% 2.2% 1.1% 2.2% |
|TERMINAL (d) | 0/76 (0%) 0/72 (0%) 1/84 (1%) 0/62 (0%) |0/70 (0%) 1/74 (1%) 1/79 (1%) 2/74 (3%) |
|FIRST INCIDENCE | --- --- 734 (T) --- |--- 559 735 (T) 735 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.804N (e) P=0.520 (e) |P=0.375 P=0.245 P=0.524 P=0.251 |
|POLY 3 | P=0.775N (e) P=0.501 (e) |P=0.368 P=0.240 P=0.501 P=0.237 |
|POLY 1.5 | P=0.772N (e) P=0.501 (e) |P=0.368 P=0.239 P=0.500 P=0.237 |
|POLY 6 | P=0.779N (e) P=0.503 (e) |P=0.370 P=0.240 P=0.502 P=0.238 |
|LOGISTIC REGRESSION| (e) (e) P=0.520 (e) |P=0.371 P=0.245 P=0.524 P=0.251 |
|COCH-ARM / FISHERS | P=0.767N (e) P=0.500 (e) |P=0.371 P=0.249 P=0.500 P=0.249 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 20
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 10/100 (10%) 6/100 (6%) 8/100 (8%) |2/100 (2%) 3/100 (3%) 1/100 (1%) 5/100 (5%) |
|POLY-3 ADJUSTED (b)| 6.4% 11.0% 6.4% 9.2% |2.2% 3.3% 1.1% 5.5% |
|TERMINAL (d) | 3/76 (4%) 6/72 (8%) 3/84 (4%) 5/62 (8%) |0/70 (0%) 3/74 (4%) 1/79 (1%) 2/74 (3%) |
|FIRST INCIDENCE | 582 400 585 518 |707 735 (T) 735 (T) 699 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.398 P=0.193 P=0.574N P=0.275 |P=0.139 P=0.516 P=0.483N P=0.237 |
|POLY 3 | P=0.473 P=0.199 P=0.611N P=0.335 |P=0.131 P=0.499 P=0.498N P=0.219 |
|POLY 1.5 | P=0.497 P=0.207 P=0.614N P=0.357 |P=0.130 P=0.499 P=0.500N P=0.217 |
|POLY 6 | P=0.445 P=0.189 P=0.605N P=0.311 |P=0.132 P=0.498 P=0.498N P=0.221 |
|LOGISTIC REGRESSION| P=0.541N P=0.264 P=0.615 P=0.403 |P=0.131 P=0.500 P=0.498N P=0.218 |
|COCH-ARM / FISHERS | P=0.536 P=0.218 P=0.616N P=0.391 |P=0.133 P=0.500 P=0.500N P=0.222 |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 10/100 (10%) 7/100 (7%) 8/100 (8%) |2/100 (2%) 5/100 (5%) 2/100 (2%) 7/100 (7%) |
|POLY-3 ADJUSTED (b)| 6.4% 11.0% 7.4% 9.2% |2.2% 5.5% 2.2% 7.8% |
|TERMINAL (d) | 3/76 (4%) 6/72 (8%) 4/84 (5%) 5/62 (8%) |0/70 (0%) 4/74 (5%) 2/79 (3%) 4/74 (5%) |
|FIRST INCIDENCE | 582 400 585 518 |707 559 735 (T) 699 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.412 P=0.193 P=0.546 P=0.275 |P=0.092 P=0.236 P=0.668N P=0.099 |
|POLY 3 | P=0.488 P=0.199 P=0.506 P=0.335 |P=0.084 P=0.222 P=0.691N P=0.084 |
|POLY 1.5 | P=0.514 P=0.207 P=0.503 P=0.357 |P=0.084 P=0.221 P=0.692N P=0.083 |
|POLY 6 | P=0.460 P=0.189 P=0.513 P=0.311 |P=0.085 P=0.223 P=0.691N P=0.085 |
|LOGISTIC REGRESSION| P=0.526N P=0.264 P=0.497 P=0.403 |P=0.084 P=0.221 P=0.691N P=0.085 |
|COCH-ARM / FISHERS | P=0.553 P=0.218 P=0.500 P=0.391 |P=0.086 P=0.222 P=0.689N P=0.085 |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 21
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 1/100 (1%) 3/100 (3%) 1/100 (1%) |2/100 (2%) 2/100 (2%) 2/100 (2%) 0/100 (0%) |
|POLY-3 ADJUSTED (b)| 1.1% 1.1% 3.2% 1.2% |2.2% 2.2% 2.2% 0.0% |
|TERMINAL (d) | 1/76 (1%) 0/72 (0%) 2/84 (2%) 0/62 (0%) |2/70 (3%) 1/74 (1%) 0/79 (0%) 0/74 (0%) |
|FIRST INCIDENCE | 734 (T) 703 717 466 |735 (T) 721 655 --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.639N P=0.747 P=0.342 P=0.736 |P=0.159N P=0.675N P=0.674N P=0.227N |
|POLY 3 | P=0.602N P=0.751 P=0.310 P=0.745 |P=0.162N P=0.693 P=0.688N P=0.240N |
|POLY 1.5 | P=0.592N P=0.755 P=0.308 P=0.751 |P=0.162N P=0.692 P=0.691N P=0.240N |
|POLY 6 | P=0.612N P=0.748 P=0.313 P=0.738 |P=0.161N P=0.692N P=0.686N P=0.239N |
|LOGISTIC REGRESSION| P=0.548N P=0.753 P=0.315 P=0.680N |P=0.160N P=0.691N P=0.693 (e) |
|COCH-ARM / FISHERS | P=0.579N P=0.751N P=0.311 P=0.751N |P=0.159N P=0.689N P=0.689N P=0.249N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 7/100 (7%) 4/100 (4%) 7/100 (7%) |32/100 (32%) 31/100 (31%) 22/100 (22%) 26/100 (26%) |
|POLY-3 ADJUSTED (b)| 8.6% 7.8% 4.3% 8.0% |34.7% 33.5% 24.0% 28.3% |
|TERMINAL (d) | 7/76 (9%) 4/72 (6%) 3/84 (4%) 3/62 (5%) |23/70 (33%) 23/74 (31%) 20/79 (25%) 20/74 (27%) |
|FIRST INCIDENCE | 691 562 701 510 |461 461 581 467 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.444 P=0.543N P=0.147N P=0.575 |P=0.238N P=0.421N P=0.034N* P=0.172N |
|POLY 3 | P=0.536 P=0.522N P=0.182N P=0.550N |P=0.253N P=0.494N P=0.074N P=0.219N |
|POLY 1.5 | P=0.552 P=0.514N P=0.184N P=0.531N |P=0.257N P=0.499N P=0.076N P=0.225N |
|POLY 6 | P=0.518 P=0.531N P=0.178N P=0.571N |P=0.247N P=0.488N P=0.074N P=0.213N |
|LOGISTIC REGRESSION| P=0.565N P=0.497N P=0.177N P=0.510N |P=0.259N P=0.502N P=0.071N P=0.226N |
|COCH-ARM / FISHERS | P=0.578 P=0.500N P=0.186N P=0.500N |P=0.250N P=0.500N P=0.076N P=0.218N |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 22
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 54/100 (54%) 50/100 (50%) 54/100 (54%) 47/100 (47%)|52/100 (52%) 49/100 (49%) 54/100 (54%) 49/100 (49%) |
|POLY-3 ADJUSTED (b)| 57.7% 54.8% 56.5% 51.3% |56.2% 52.2% 58.6% 54.1% |
|TERMINAL (d) | 47/76 (62%) 42/72 (58%) 46/84 (55%) 30/62 (48%) |44/70 (63%) 38/74 (51%) 49/79 (62%) 46/74 (62%) |
|FIRST INCIDENCE | 646 542 562 483 |542 64 578 566 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.331 P=0.492N P=0.300N P=0.438 |P=0.364N P=0.278N P=0.350N P=0.249N |
|POLY 3 | P=0.234N P=0.402N P=0.490N P=0.230N |P=0.496N P=0.339N P=0.431 P=0.442N |
|POLY 1.5 | P=0.227N P=0.373N P=0.520N P=0.219N |P=0.477N P=0.351N P=0.427 P=0.432N |
|POLY 6 | P=0.236N P=0.436N P=0.443N P=0.238N |P=0.516N P=0.326N P=0.421 P=0.452N |
|LOGISTIC REGRESSION| P=0.355N P=0.501N P=0.540N P=0.329N |P=0.425N P=0.391N P=0.465 P=0.395N |
|COCH-ARM / FISHERS | P=0.211N P=0.336N P=0.556N P=0.198N |P=0.404N P=0.389N P=0.444 P=0.389N |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 40/100 (40%) 49/100 (49%) 45/100 (45%) 49/100 (49%)|55/100 (55%) 58/100 (58%) 39/100 (39%) 40/100 (40%) |
|POLY-3 ADJUSTED (b)| 41.3% 50.3% 46.1% 51.4% |57.6% 59.6% 41.1% 42.5% |
|TERMINAL (d) | 25/76 (33%) 27/72 (38%) 35/84 (42%) 23/62 (37%) |34/70 (49%) 37/74 (50%) 29/79 (37%) 26/74 (35%) |
|FIRST INCIDENCE | 520 400 430 448 |397 461 513 183 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.062 P=0.108 P=0.460 P=0.037 * |P=0.023N* P=0.503 P=0.010N* P=0.030N* |
|POLY 3 | P=0.205 P=0.134 P=0.302 P=0.103 |P=0.014N* P=0.448 P=0.015N* P=0.024N* |
|POLY 1.5 | P=0.222 P=0.132 P=0.296 P=0.111 |P=0.012N* P=0.419 P=0.016N* P=0.024N* |
|POLY 6 | P=0.188 P=0.136 P=0.307 P=0.095 |P=0.015N* P=0.477 P=0.015N* P=0.025N* |
|LOGISTIC REGRESSION| P=0.408 P=0.192 P=0.274 P=0.219 |P=0.012N* P=0.387 P=0.017N* P=0.024N* |
|COCH-ARM / FISHERS | P=0.255 P=0.127 P=0.284 P=0.127 |P=0.011N* P=0.388 P=0.017N* P=0.024N* |
|=================================================================================================================================|
Date: 01/06/98 EXPERIMENT: 89029 TEST: 06 Page 23
Statistical Analysis of Primary Tumors in Mice(B6C3F1) - MAGNETIC FIELDS (EMF)
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | SHAM 0.02 2 GAUSS 10 GAUSS |SHAM 0.02 2 GAUSS 10 GAUSS |
| | CONTROL GAUSS |CONTROL GAUSS |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 71/100 (71%) 81/100 (81%) 72/100 (72%) 74/100 (74%)|78/100 (78%) 80/100 (80%) 72/100 (72%) 71/100 (71%) |
|POLY-3 ADJUSTED (b)| 73.0% 82.2% 73.3% 76.5% |81.0% 81.2% 75.8% 74.9% |
|TERMINAL (d) | 53/76 (70%) 56/72 (78%) 60/84 (71%) 43/62 (69%) |54/70 (77%) 56/74 (76%) 60/79 (76%) 55/74 (74%) |
|FIRST INCIDENCE | 520 400 430 448 |397 64 513 183 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.081 P=0.060 P=0.310N P=0.050 |P=0.143N P=0.492N P=0.064N P=0.131N |
|POLY 3 | P=0.506N P=0.081 P=0.547 P=0.343 |P=0.158N P=0.561 P=0.237N P=0.193N |
|POLY 1.5 | P=0.483N P=0.075 P=0.533 P=0.353 |P=0.139N P=0.522 P=0.236N P=0.185N |
|POLY 6 | P=0.523N P=0.087 P=0.556 P=0.338 |P=0.181N P=0.552N P=0.259N P=0.208N |
|LOGISTIC REGRESSION| P=0.425N P=0.067 P=0.502 P=0.352 |P=0.116N P=0.426 P=0.196N P=0.184N |
|COCH-ARM / FISHERS | P=0.435N P=0.068 P=0.500 P=0.376 |P=0.103N P=0.431 P=0.207N P=0.165N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).