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TDMS Study 89029-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: I. I. T. Research Inst                               MAGNETIC FIELDS (EMF)                                DATE: 01/06/98

EXPERIMENT: 89029 TEST: 06                                                                                     TIME: 08:58:27
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-25351                              ROUTE: MAGNETIC FIELDS                                         NTP C#: C89029
PATHOLOGIST: PLETCHER, J                                                                                       CAS: ELECTROMAG
            

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: I. I. T. Research Inst                               MAGNETIC FIELDS (EMF)                                DATE: 01/06/98     
EXPERIMENT: 89029 TEST: 06                                                                                     TIME: 08:58:27     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-25351                              ROUTE: MAGNETIC FIELDS                                         NTP C#: C89029     
PATHOLOGIST: PLETCHER, J                                                                                       CAS: ELECTROMAG    



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF               MAGNETIC FIELDS (EMF)
===============================================================

Female Mice
------------
Organ                                  Morphology
-----                                  ----------
All Organs                             Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type
                                       Malignant and Benign Tumors
===============================================================
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  3/99 (3%)                0/97 (0%)    |           0/92 (0%)                0/99 (0%)       |
|POLY-3 ADJUSTED (b)|                  3.3%                     0.0%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  3/76 (4%)                0/73 (0%)    |           0/70 (0%)                0/77 (0%)       |
|FIRST INCIDENCE    |                  734 (T)                  ---          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.130N     |                                    (e)             |
|POLY 3             |                                           P=0.133N     |                                    (e)             |
|POLY 1.5           |                                           P=0.131N     |                                    (e)             |
|POLY 6             |                                           P=0.136N     |                                    (e)             |
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.127N     |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  12/100 (12%)             11/100 (11%) |           10/100 (10%)             13/100 (13%)    |
|POLY-3 ADJUSTED (b)|                  13.0%                    12.0%        |           11.0%                    14.4%           |
|TERMINAL (d)       |                  11/76 (15%)              8/74 (11%)   |           7/70 (10%)               12/77 (16%)     |
|FIRST INCIDENCE    |                  716                      533          |           625                      715             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.528N     |                                    P=0.404         |
|POLY 3             |                                           P=0.511N     |                                    P=0.323         |
|POLY 1.5           |                                           P=0.507N     |                                    P=0.328         |
|POLY 6             |                                           P=0.515N     |                                    P=0.315         |
|LOGISTIC REGRESSION|                                           P=0.514N     |                                    P=0.323         |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.329         |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               3/100 (3%)   |           2/100 (2%)               0/100 (0%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     3.3%         |           2.2%                     0.0%            |
|TERMINAL (d)       |                  0/76 (0%)                3/74 (4%)    |           2/70 (3%)                0/77 (0%)       |
|FIRST INCIDENCE    |                  ---                      734 (T)      |           735 (T)                  ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.118      |                                    P=0.218N        |
|POLY 3             |                                           P=0.118      |                                    P=0.238N        |
|POLY 1.5           |                                           P=0.120      |                                    P=0.238N        |
|POLY 6             |                                           P=0.117      |                                    P=0.240N        |
|LOGISTIC REGRESSION|                                           P=0.118      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.123      |                                    P=0.249N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  12/100 (12%)             14/100 (14%) |           12/100 (12%)             13/100 (13%)    |
|POLY-3 ADJUSTED (b)|                  13.0%                    15.3%        |           13.2%                    14.4%           |
|TERMINAL (d)       |                  11/76 (15%)              11/74 (15%)  |           9/70 (13%)               12/77 (16%)     |
|FIRST INCIDENCE    |                  716                      533          |           625                      715             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.388      |                                    P=0.584         |
|POLY 3             |                                           P=0.405      |                                    P=0.495         |
|POLY 1.5           |                                           P=0.409      |                                    P=0.500         |
|POLY 6             |                                           P=0.402      |                                    P=0.486         |
|LOGISTIC REGRESSION|                                           P=0.397      |                                    P=0.494         |
|COCH-ARM / FISHERS |                                           P=0.417      |                                    P=0.500         |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/99 (1%)                1/98 (1%)    |           2/87 (2%)                3/94 (3%)       |
|POLY-3 ADJUSTED (b)|                  1.1%                     1.1%         |           2.4%                     3.5%            |
|TERMINAL (d)       |                  1/76 (1%)                0/74 (0%)    |           1/70 (1%)                3/76 (4%)       |
|FIRST INCIDENCE    |                  734 (T)                  666          |           542                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.754      |                                    P=0.531         |
|POLY 3             |                                           P=0.757      |                                    P=0.518         |
|POLY 1.5           |                                           P=0.758      |                                    P=0.522         |
|POLY 6             |                                           P=0.756      |                                    P=0.513         |
|LOGISTIC REGRESSION|                                           P=0.761N     |                                    P=0.541         |
|COCH-ARM / FISHERS |                                           P=0.749      |                                    P=0.537         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  3/99 (3%)                1/98 (1%)    |           2/87 (2%)                3/94 (3%)       |
|POLY-3 ADJUSTED (b)|                  3.2%                     1.1%         |           2.4%                     3.5%            |
|TERMINAL (d)       |                  2/76 (3%)                0/74 (0%)    |           1/70 (1%)                3/76 (4%)       |
|FIRST INCIDENCE    |                  534                      666          |           542                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.318N     |                                    P=0.531         |
|POLY 3             |                                           P=0.324N     |                                    P=0.518         |
|POLY 1.5           |                                           P=0.319N     |                                    P=0.522         |
|POLY 6             |                                           P=0.328N     |                                    P=0.513         |
|LOGISTIC REGRESSION|                                           P=0.283N     |                                    P=0.541         |
|COCH-ARM / FISHERS |                                           P=0.314N     |                                    P=0.537         |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/99 (2%)                0/97 (0%)    |           0/92 (0%)                0/99 (0%)       |
|POLY-3 ADJUSTED (b)|                  2.2%                     0.0%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  1/76 (1%)                0/73 (0%)    |           0/70 (0%)                0/77 (0%)       |
|FIRST INCIDENCE    |                  534                      ---          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.246N     |                                    (e)             |
|POLY 3             |                                           P=0.259N     |                                    (e)             |
|POLY 1.5           |                                           P=0.253N     |                                    (e)             |
|POLY 6             |                                           P=0.265N     |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.207N     |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.254N     |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  4/100 (4%)               4/99 (4%)    |           1/98 (1%)                0/100 (0%)      |
|POLY-3 ADJUSTED (b)|                  4.3%                     4.5%         |           1.1%                     0.0%            |
|TERMINAL (d)       |                  1/76 (1%)                3/74 (4%)    |           0/70 (0%)                0/77 (0%)       |
|FIRST INCIDENCE    |                  582                      666          |           723                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.622      |                                    P=0.500N        |
|POLY 3             |                                           P=0.622      |                                    P=0.496N        |
|POLY 1.5           |                                           P=0.627      |                                    P=0.493N        |
|POLY 6             |                                           P=0.616      |                                    P=0.500N        |
|LOGISTIC REGRESSION|                                           P=0.633N     |                                    P=0.498N        |
|COCH-ARM / FISHERS |                                           P=0.634      |                                    P=0.495N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  2/100 (2%)               5/99 (5%)    |           0/98 (0%)                0/100 (0%)      |
|POLY-3 ADJUSTED (b)|                  2.2%                     5.5%         |           0.0%                     0.0%            |
|TERMINAL (d)       |                  1/76 (1%)                2/74 (3%)    |           0/70 (0%)                0/77 (0%)       |
|FIRST INCIDENCE    |                  731                      666          |           ---                      ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.209      |                                    (e)             |
|POLY 3             |                                           P=0.212      |                                    (e)             |
|POLY 1.5           |                                           P=0.214      |                                    (e)             |
|POLY 6             |                                           P=0.211      |                                    (e)             |
|LOGISTIC REGRESSION|                                           P=0.217      |                                    (e)             |
|COCH-ARM / FISHERS |                                           P=0.218      |                                    (e)             |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  30/100 (30%)             32/99 (32%)  |           17/98 (17%)              13/100 (13%)    |
|POLY-3 ADJUSTED (b)|                  32.3%                    35.3%        |           19.0%                    14.3%           |
|TERMINAL (d)       |                  28/76 (37%)              29/74 (39%)  |           16/70 (23%)              11/77 (14%)     |
|FIRST INCIDENCE    |                  646                      415          |           667                      679             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.385      |                                    P=0.198N        |
|POLY 3             |                                           P=0.391      |                                    P=0.262N        |
|POLY 1.5           |                                           P=0.403      |                                    P=0.257N        |
|POLY 6             |                                           P=0.377      |                                    P=0.270N        |
|LOGISTIC REGRESSION|                                           P=0.363      |                                    P=0.277N        |
|COCH-ARM / FISHERS |                                           P=0.420      |                                    P=0.257N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  19/100 (19%)             23/99 (23%)  |           6/98 (6%)                6/100 (6%)      |
|POLY-3 ADJUSTED (b)|                  19.8%                    24.4%        |           6.7%                     6.6%            |
|TERMINAL (d)       |                  8/76 (11%)               9/74 (12%)   |           4/70 (6%)                5/77 (7%)       |
|FIRST INCIDENCE    |                  520                      456          |           691                      679             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.279      |                                    P=0.573N        |
|POLY 3             |                                           P=0.279      |                                    P=0.610N        |
|POLY 1.5           |                                           P=0.283      |                                    P=0.604N        |
|POLY 6             |                                           P=0.278      |                                    P=0.617         |
|LOGISTIC REGRESSION|                                           P=0.366      |                                    P=0.613N        |
|COCH-ARM / FISHERS |                                           P=0.289      |                                    P=0.602N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  21/100 (21%)             27/99 (27%)  |           6/98 (6%)                6/100 (6%)      |
|POLY-3 ADJUSTED (b)|                  21.9%                    28.5%        |           6.7%                     6.6%            |
|TERMINAL (d)       |                  9/76 (12%)               11/74 (15%)  |           4/70 (6%)                5/77 (7%)       |
|FIRST INCIDENCE    |                  520                      456          |           691                      679             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.194      |                                    P=0.573N        |
|POLY 3             |                                           P=0.189      |                                    P=0.610N        |
|POLY 1.5           |                                           P=0.189      |                                    P=0.604N        |
|POLY 6             |                                           P=0.191      |                                    P=0.617         |
|LOGISTIC REGRESSION|                                           P=0.248      |                                    P=0.613N        |
|COCH-ARM / FISHERS |                                           P=0.193      |                                    P=0.602N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  46/100 (46%)             52/99 (53%)  |           22/98 (22%)              18/100 (18%)    |
|POLY-3 ADJUSTED (b)|                  47.8%                    54.5%        |           24.5%                    19.8%           |
|TERMINAL (d)       |                  34/76 (45%)              36/74 (49%)  |           19/70 (27%)              16/77 (21%)     |
|FIRST INCIDENCE    |                  520                      415          |           667                      679             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.212      |                                    P=0.208N        |
|POLY 3             |                                           P=0.215      |                                    P=0.284N        |
|POLY 1.5           |                                           P=0.217      |                                    P=0.276N        |
|POLY 6             |                                           P=0.215      |                                    P=0.299N        |
|LOGISTIC REGRESSION|                                           P=0.231      |                                    P=0.298N        |
|COCH-ARM / FISHERS |                                           P=0.218      |                                    P=0.274N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  47/100 (47%)             55/99 (56%)  |           22/98 (22%)              18/100 (18%)    |
|POLY-3 ADJUSTED (b)|                  48.8%                    57.4%        |           24.5%                    19.8%           |
|TERMINAL (d)       |                  34/76 (45%)              37/74 (50%)  |           19/70 (27%)              16/77 (21%)     |
|FIRST INCIDENCE    |                  520                      415          |           667                      679             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.150      |                                    P=0.208N        |
|POLY 3             |                                           P=0.147      |                                    P=0.284N        |
|POLY 1.5           |                                           P=0.145      |                                    P=0.276N        |
|POLY 6             |                                           P=0.153      |                                    P=0.299N        |
|LOGISTIC REGRESSION|                                           P=0.153      |                                    P=0.298N        |
|COCH-ARM / FISHERS |                                           P=0.143      |                                    P=0.274N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  26/100 (26%)             16/99 (16%)  |           9/95 (9%)                6/100 (6%)      |
|POLY-3 ADJUSTED (b)|                  28.0%                    17.9%        |           10.2%                    6.6%            |
|TERMINAL (d)       |                  22/76 (29%)              15/74 (20%)  |           7/70 (10%)               6/77 (8%)       |
|FIRST INCIDENCE    |                  683                      672          |           551                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.074N     |                                    P=0.239N        |
|POLY 3             |                                           P=0.073N     |                                    P=0.275N        |
|POLY 1.5           |                                           P=0.069N     |                                    P=0.267N        |
|POLY 6             |                                           P=0.078N     |                                    P=0.286N        |
|LOGISTIC REGRESSION|                                           P=0.077N     |                                    P=0.272N        |
|COCH-ARM / FISHERS |                                           P=0.063N     |                                    P=0.261N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  8/100 (8%)               10/99 (10%)  |           2/95 (2%)                1/100 (1%)      |
|POLY-3 ADJUSTED (b)|                  8.6%                     11.2%        |           2.3%                     1.1%            |
|TERMINAL (d)       |                  7/76 (9%)                9/74 (12%)   |           0/70 (0%)                0/77 (0%)       |
|FIRST INCIDENCE    |                  715                      668          |           701                      656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.376      |                                    P=0.504N        |
|POLY 3             |                                           P=0.377      |                                    P=0.483N        |
|POLY 1.5           |                                           P=0.383      |                                    P=0.480N        |
|POLY 6             |                                           P=0.371      |                                    P=0.489N        |
|LOGISTIC REGRESSION|                                           P=0.363      |                                    P=0.480N        |
|COCH-ARM / FISHERS |                                           P=0.394      |                                    P=0.481N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  30/100 (30%)             23/99 (23%)  |           11/95 (12%)              7/100 (7%)      |
|POLY-3 ADJUSTED (b)|                  32.2%                    25.6%        |           12.5%                    7.7%            |
|TERMINAL (d)       |                  25/76 (33%)              21/74 (28%)  |           7/70 (10%)               6/77 (8%)       |
|FIRST INCIDENCE    |                  683                      668          |           551                      656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.205N     |                                    P=0.189N        |
|POLY 3             |                                           P=0.203N     |                                    P=0.208N        |
|POLY 1.5           |                                           P=0.194N     |                                    P=0.201N        |
|POLY 6             |                                           P=0.214N     |                                    P=0.218N        |
|LOGISTIC REGRESSION|                                           P=0.215N     |                                    P=0.202N        |
|COCH-ARM / FISHERS |                                           P=0.179N     |                                    P=0.196N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               0/100 (0%)   |           1/100 (1%)               2/100 (2%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           1.1%                     2.2%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           0/70 (0%)                2/77 (3%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           707                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.521         |
|POLY 3             |                                           (e)          |                                    P=0.500         |
|POLY 1.5           |                                           (e)          |                                    P=0.500         |
|POLY 6             |                                           (e)          |                                    P=0.498         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.499         |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.500         |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               0/100 (0%)   |           1/100 (1%)               2/100 (2%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           1.1%                     2.2%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           0/70 (0%)                2/77 (3%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           707                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.521         |
|POLY 3             |                                           (e)          |                                    P=0.500         |
|POLY 1.5           |                                           (e)          |                                    P=0.500         |
|POLY 6             |                                           (e)          |                                    P=0.498         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.499         |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |           3/79 (4%)                0/96 (0%)       |
|POLY-3 ADJUSTED (b)|                                                        |           4.0%                     0.0%            |
|TERMINAL (d)       |                                                        |           3/65 (5%)                0/77 (0%)       |
|FIRST INCIDENCE    |                                                        |           735 (T)                  ---             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |                                    P=0.094N        |
|POLY 3             |                                                        |                                    P=0.085N        |
|POLY 1.5           |                                                        |                                    P=0.083N        |
|POLY 6             |                                                        |                                    P=0.088N        |
|LOGISTIC REGRESSION|                                                        |                                    (e)             |
|COCH-ARM / FISHERS |                                                        |                                    P=0.090N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |           0/79 (0%)                2/96 (2%)       |
|POLY-3 ADJUSTED (b)|                                                        |           0.0%                     2.3%            |
|TERMINAL (d)       |                                                        |           0/65 (0%)                2/77 (3%)       |
|FIRST INCIDENCE    |                                                        |           ---                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |                                    P=0.277         |
|POLY 3             |                                                        |                                    P=0.256         |
|POLY 1.5           |                                                        |                                    P=0.257         |
|POLY 6             |                                                        |                                    P=0.254         |
|LOGISTIC REGRESSION|                                                        |                                    P=0.277         |
|COCH-ARM / FISHERS |                                                        |                                    P=0.300         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/83 (0%)                0/86 (0%)    |           17/83 (20%)              16/93 (17%)     |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           21.9%                    18.7%           |
|TERMINAL (d)       |                  0/66 (0%)                0/67 (0%)    |           16/67 (24%)              15/74 (20%)     |
|FIRST INCIDENCE    |                  ---                      ---          |           625                      710             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.382N        |
|POLY 3             |                                           (e)          |                                    P=0.373N        |
|POLY 1.5           |                                           (e)          |                                    P=0.364N        |
|POLY 6             |                                           (e)          |                                    P=0.388N        |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.392N        |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.358N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skeletal Muscle                                                                                                                  |
|     Rhabdomyosarcoma                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               0/100 (0%)   |           3/100 (3%)               1/100 (1%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           3.3%                     1.1%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           2/70 (3%)                0/77 (0%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           707                      534             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.292N        |
|POLY 3             |                                           (e)          |                                    P=0.304N        |
|POLY 1.5           |                                           (e)          |                                    P=0.304N        |
|POLY 6             |                                           (e)          |                                    P=0.306N        |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.312N        |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.311N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               1/100 (1%)   |           4/100 (4%)               5/100 (5%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     1.1%         |           4.4%                     5.4%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           1/70 (1%)                2/77 (3%)       |
|FIRST INCIDENCE    |                  ---                      605          |           625                      481             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.496      |                                    P=0.512         |
|POLY 3             |                                           P=0.500      |                                    P=0.505         |
|POLY 1.5           |                                           P=0.500      |                                    P=0.504         |
|POLY 6             |                                           P=0.500      |                                    P=0.503         |
|LOGISTIC REGRESSION|                                           P=0.534      |                                    P=0.483         |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.500         |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 13
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               1/100 (1%)   |           4/100 (4%)               5/100 (5%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     1.1%         |           4.4%                     5.4%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           1/70 (1%)                2/77 (3%)       |
|FIRST INCIDENCE    |                  ---                      605          |           625                      481             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.496      |                                    P=0.512         |
|POLY 3             |                                           P=0.500      |                                    P=0.505         |
|POLY 1.5           |                                           P=0.500      |                                    P=0.504         |
|POLY 6             |                                           P=0.500      |                                    P=0.503         |
|LOGISTIC REGRESSION|                                           P=0.534      |                                    P=0.483         |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.500         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Neurofibrosarcoma, Neurofibroma, or Schwannoma (benign,                                                                     |
|     malignant or NOS)                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               0/100 (0%)   |           2/100 (2%)               2/100 (2%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           2.2%                     2.2%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           1/70 (1%)                1/77 (1%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           608                      656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.678N        |
|POLY 3             |                                           (e)          |                                    P=0.692         |
|POLY 1.5           |                                           (e)          |                                    P=0.692N        |
|POLY 6             |                                           (e)          |                                    P=0.691         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.690         |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.689N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 14
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               1/100 (1%)   |           4/100 (4%)               4/100 (4%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     1.1%         |           4.4%                     4.4%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           1/70 (1%)                2/77 (3%)       |
|FIRST INCIDENCE    |                  ---                      605          |           625                      580             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.496      |                                    P=0.628N        |
|POLY 3             |                                           P=0.500      |                                    P=0.640N        |
|POLY 1.5           |                                           P=0.500      |                                    P=0.639N        |
|POLY 6             |                                           P=0.500      |                                    P=0.639         |
|LOGISTIC REGRESSION|                                           P=0.534      |                                    P=0.636         |
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.640N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Schwannoma Malignant                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               0/100 (0%)   |           2/100 (2%)               2/100 (2%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           2.2%                     2.2%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           1/70 (1%)                1/77 (1%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           608                      656             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.678N        |
|POLY 3             |                                           (e)          |                                    P=0.692         |
|POLY 1.5           |                                           (e)          |                                    P=0.692N        |
|POLY 6             |                                           (e)          |                                    P=0.691         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.690         |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.689N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 15
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  0/100 (0%)               0/100 (0%)   |           0/100 (0%)               2/100 (2%)      |
|POLY-3 ADJUSTED (b)|                  0.0%                     0.0%         |           0.0%                     2.2%            |
|TERMINAL (d)       |                  0/76 (0%)                0/74 (0%)    |           0/70 (0%)                2/77 (3%)       |
|FIRST INCIDENCE    |                  ---                      ---          |           ---                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           (e)          |                                    P=0.260         |
|POLY 3             |                                           (e)          |                                    P=0.238         |
|POLY 1.5           |                                           (e)          |                                    P=0.239         |
|POLY 6             |                                           (e)          |                                    P=0.238         |
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.260         |
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.249         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  6/100 (6%)               5/100 (5%)   |           2/100 (2%)               3/100 (3%)      |
|POLY-3 ADJUSTED (b)|                  6.4%                     5.5%         |           2.2%                     3.3%            |
|TERMINAL (d)       |                  3/76 (4%)                4/74 (5%)    |           0/70 (0%)                3/77 (4%)       |
|FIRST INCIDENCE    |                  582                      666          |           707                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.520N     |                                    P=0.524         |
|POLY 3             |                                           P=0.524N     |                                    P=0.499         |
|POLY 1.5           |                                           P=0.515N     |                                    P=0.501         |
|POLY 6             |                                           P=0.535N     |                                    P=0.497         |
|LOGISTIC REGRESSION|                                           P=0.496N     |                                    P=0.498         |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500         |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 16
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  6/100 (6%)               5/100 (5%)   |           2/100 (2%)               5/100 (5%)      |
|POLY-3 ADJUSTED (b)|                  6.4%                     5.5%         |           2.2%                     5.5%            |
|TERMINAL (d)       |                  3/76 (4%)                4/74 (5%)    |           0/70 (0%)                5/77 (7%)       |
|FIRST INCIDENCE    |                  582                      666          |           707                      735 (T)         |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.520N     |                                    P=0.250         |
|POLY 3             |                                           P=0.524N     |                                    P=0.220         |
|POLY 1.5           |                                           P=0.515N     |                                    P=0.221         |
|POLY 6             |                                           P=0.535N     |                                    P=0.218         |
|LOGISTIC REGRESSION|                                           P=0.496N     |                                    P=0.218         |
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.222         |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  1/100 (1%)               1/100 (1%)   |           2/100 (2%)               6/100 (6%)      |
|POLY-3 ADJUSTED (b)|                  1.1%                     1.1%         |           2.2%                     6.5%            |
|TERMINAL (d)       |                  1/76 (1%)                1/74 (1%)    |           2/70 (3%)                1/77 (1%)       |
|FIRST INCIDENCE    |                  734 (T)                  734 (T)      |           735 (T)                  309             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.755      |                                    P=0.155         |
|POLY 3             |                                           P=0.758      |                                    P=0.146         |
|POLY 1.5           |                                           P=0.759      |                                    P=0.144         |
|POLY 6             |                                           P=0.757      |                                    P=0.147         |
|LOGISTIC REGRESSION|                                           P=0.755      |                                    P=0.118         |
|COCH-ARM / FISHERS |                                           P=0.751N     |                                    P=0.140         |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 17
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  8/100 (8%)               6/100 (6%)   |           32/100 (32%)             20/100 (20%)    |
|POLY-3 ADJUSTED (b)|                  8.6%                     6.6%         |           34.7%                    21.7%           |
|TERMINAL (d)       |                  7/76 (9%)                3/74 (4%)    |           23/70 (33%)              15/77 (20%)     |
|FIRST INCIDENCE    |                  691                      579          |           461                      567             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.414N     |                                    P=0.024N*       |
|POLY 3             |                                           P=0.402N     |                                    P=0.035N*       |
|POLY 1.5           |                                           P=0.399N     |                                    P=0.035N*       |
|POLY 6             |                                           P=0.405N     |                                    P=0.035N*       |
|LOGISTIC REGRESSION|                                           P=0.391N     |                                    P=0.037N*       |
|COCH-ARM / FISHERS |                                           P=0.391N     |                                    P=0.038N*       |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  54/100 (54%)             52/100 (52%) |           52/100 (52%)             44/100 (44%)    |
|POLY-3 ADJUSTED (b)|                  57.7%                    55.9%        |           56.2%                    48.0%           |
|TERMINAL (d)       |                  47/76 (62%)              44/74 (60%)  |           44/70 (63%)              38/77 (49%)     |
|FIRST INCIDENCE    |                  646                      415          |           542                      576             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.531N     |                                    P=0.063N        |
|POLY 3             |                                           P=0.458N     |                                    P=0.162N        |
|POLY 1.5           |                                           P=0.451N     |                                    P=0.156N        |
|POLY 6             |                                           P=0.471N     |                                    P=0.172N        |
|LOGISTIC REGRESSION|                                           P=0.534N     |                                    P=0.158N        |
|COCH-ARM / FISHERS |                                           P=0.444N     |                                    P=0.161N        |
|=================================================================================================================================|
       Date:  01/06/98                           EXPERIMENT: 89029 TEST: 06                                            Page 18
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                MAGNETIC FIELDS (EMF)
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  40/100 (40%)             48/100 (48%) |           55/100 (55%)             45/100 (45%)    |
|POLY-3 ADJUSTED (b)|                  41.3%                    49.7%        |           57.6%                    46.2%           |
|TERMINAL (d)       |                  25/76 (33%)              29/74 (39%)  |           34/70 (49%)              27/77 (35%)     |
|FIRST INCIDENCE    |                  520                      456          |           397                      309             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.155      |                                    P=0.085N        |
|POLY 3             |                                           P=0.153      |                                    P=0.071N        |
|POLY 1.5           |                                           P=0.154      |                                    P=0.079N        |
|POLY 6             |                                           P=0.156      |                                    P=0.065N        |
|LOGISTIC REGRESSION|                                           P=0.185      |                                    P=0.103N        |
|COCH-ARM / FISHERS |                                           P=0.159      |                                    P=0.101N        |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |                  SHAM                     10 GAUSS     |           SHAM                     10 GAUSS        |
|                   |                  CONTROL                   INTER.      |           CONTROL                   INTER.         |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                  #                        #            |           #                        #               |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                  71/100 (71%)             76/100 (76%) |           78/100 (78%)             68/100 (68%)    |
|POLY-3 ADJUSTED (b)|                  73.0%                    77.9%        |           81.0%                    69.7%           |
|TERMINAL (d)       |                  53/76 (70%)              54/74 (73%)  |           54/70 (77%)              49/77 (64%)     |
|FIRST INCIDENCE    |                  520                      415          |           397                      309             |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                           P=0.228      |                                    P=0.053N        |
|POLY 3             |                                           P=0.266      |                                    P=0.045N*       |
|POLY 1.5           |                                           P=0.263      |                                    P=0.051N        |
|POLY 6             |                                           P=0.273      |                                    P=0.042N*       |
|LOGISTIC REGRESSION|                                           P=0.246      |                                    P=0.073N        |
|COCH-ARM / FISHERS |                                           P=0.261      |                                    P=0.076N        |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).