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TDMS Study 90004-07 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Northwest                        PROPYLENE GLYCOL MONO-T-BUTYL ETHER                                  DATE: 11/14/01  
EXPERIMENT: 90004 TEST: 07                                                                                        TIME: 10:02:13    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                        NTP:  C90004      
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                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE NORTHWEST                               PROPYLENE GLYCOL MONO-T-BUTYL ETHER                         DATE: 11/14/01    
EXPERIMENT: 90004 TEST: 07                                                                                        TIME: 10:07:40    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: RESPIRATORY EX                                         NTP:  C90004      
CONT: N01-ES-55392                                                                                                CAS: 57018-52-7   
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                                     
                   TWO YEAR RESPIRATORY EX STUDY OF PROPYLENE GLYCOL MONO-T-BUTYL ETHER                                             
==========================================================================================================                          
WEEK     CONTROL                75 PPM                   300 PPM                  1200 PPM                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        98.0       50        98.6    100.6    50      96.2     98.2    50      96.9     98.9    50                               
  1        98.0       50        98.6    100.6    50      96.2     98.2    50      96.9     98.9    50                               
  5       229.0       50       235.4    102.8    50     231.8    101.2    49     224.6     98.1    50                               
  9       299.2       50       304.6    101.8    50     300.8    100.5    49     294.1     98.3    50                               
 13       341.6       50       344.4    100.8    50     343.7    100.6    49     340.9     99.8    50                               
 17       377.6       50       380.9    100.9    50     377.0     99.8    49     373.2     98.8    50                               
 21       399.8       50       402.1    100.6    50     398.9     99.8    49     391.9     98.0    50                               
 25       423.7       50       425.2    100.4    50     420.3     99.2    49     413.1     97.5    50                               
 29       445.2       50       446.8    100.4    50     439.2     98.7    49     432.0     97.0    50                               
 33       461.0       50       463.9    100.6    50     452.9     98.2    49     445.3     96.6    50                               
 37       471.9       50       475.3    100.7    50     464.1     98.3    49     454.4     96.3    49                               
 41       478.4       50       483.2    101.0    50     469.7     98.2    49     463.1     96.8    49                               
 45       489.3       49       494.9    101.1    50     481.3     98.4    49     474.7     97.0    49                               
 49       500.3       49       502.0    100.3    50     490.3     98.0    49     482.2     96.4    49                               
 53       504.7       49       505.3    100.1    50     497.0     98.5    48     486.9     96.5    49                               
 57       504.3       49       505.1    100.2    50     498.5     98.8    48     490.5     97.3    49                               
 61       513.7       48       513.4     99.9    50     504.1     98.1    48     493.7     96.1    49                               
 65       517.8       48       519.1    100.3    50     511.3     98.7    47     498.8     96.3    49                               
 69       528.2       46       528.2    100.0    49     517.2     97.9    47     504.5     95.5    49                               
 73       534.6       46       530.3     99.2    49     516.0     96.5    47     504.5     94.4    49                               
 77       540.3       46       535.6     99.1    46     525.0     97.2    45     507.1     93.9    47                               
 81       539.9       45       538.3     99.7    46     522.9     96.9    41     510.1     94.5    45                               
 85       537.3       45       539.6    100.4    44     521.0     97.0    38     500.3     93.1    44                               
 89       529.3       44       533.6    100.8    44     525.1     99.2    34     499.5     94.4    41                               
 92       532.2       40       529.5     99.5    43     521.6     98.0    32     495.5     93.1    37                               
 94       536.1       35       537.3    100.2    39     524.7     97.9    28     493.7     92.1    34                               
 96       537.8       33       537.0     99.9    37     520.5     96.8    26     497.2     92.5    30                               
 98       537.3       32       537.4    100.0    36     518.8     96.6    24     494.0     91.9    28                               
100       536.1       31       537.0    100.2    34     522.0     97.4    20     494.4     92.2    25                               
102       520.6       31       529.3    101.7    32     513.2     98.6    19     482.6     92.7    25                               
104       513.3       27       518.5    101.0    29     514.0    100.1    16     481.2     93.7    22                               
TERM. SAC.            27                         29                       16                       22                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                   
                   TWO YEAR RESPIRATORY EX STUDY OF PROPYLENE GLYCOL MONO-T-BUTYL ETHER                                             
==========================================================================================================                          
WEEK     CONTROL                75 PPM                   300 PPM                  1200 PPM                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        88.3       50        88.3    100.0    50      88.6    100.3    50      87.8     99.4    50                               
  1        88.3       50        88.3    100.0    50      88.6    100.3    50      87.8     99.4    50                               
  5       151.6       50       153.2    101.1    50     152.5    100.6    50     153.3    101.1    50                               
  9       177.5       50       175.8     99.0    50     176.4     99.4    50     177.0     99.7    50                               
 13       194.4       50       193.1     99.3    50     193.0     99.3    50     195.6    100.6    50                               
 17       207.6       50       205.6     99.0    50     204.4     98.5    50     205.1     98.8    50                               
 21       214.5       50       215.6    100.5    50     215.0    100.2    50     211.6     98.6    50                               
 25       224.0       49       225.6    100.7    50     221.3     98.8    50     218.4     97.5    50                               
 29       232.9       49       234.8    100.8    50     228.5     98.1    50     227.0     97.5    50                               
 33       241.8       49       243.9    100.9    50     235.5     97.4    50     233.1     96.4    50                               
 37       249.8       49       252.1    100.9    50     243.6     97.5    50     240.0     96.1    50                               
 41       256.3       48       261.4    102.0    50     252.7     98.6    50     249.0     97.2    49                               
 45       267.0       48       273.1    102.3    50     262.0     98.1    50     258.0     96.6    49                               
 49       279.1       48       286.1    102.5    50     277.2     99.3    50     269.2     96.5    49                               
 53       289.3       48       296.4    102.5    50     287.2     99.3    50     277.9     96.1    49                               
 57       295.0       47       302.9    102.7    50     295.3    100.1    50     284.0     96.3    49                               
 61       304.6       46       312.9    102.7    49     304.9    100.1    50     292.2     95.9    49                               
 65       314.0       46       322.4    102.7    49     312.3     99.5    50     297.7     94.8    49                               
 69       321.8       46       330.1    102.6    49     319.4     99.3    49     303.6     94.3    49                               
 73       331.3       46       339.6    102.5    49     323.9     97.8    48     311.6     94.1    49                               
 77       334.7       46       344.8    103.0    49     335.9    100.4    45     318.0     95.0    48                               
 81       339.8       44       347.7    102.3    49     338.1     99.5    44     320.9     94.4    46                               
 85       343.4       43       354.0    103.1    49     342.8     99.8    43     326.0     94.9    45                               
 89       351.1       42       356.6    101.6    49     343.5     97.8    40     330.1     94.0    44                               
 92       358.0       41       362.0    101.1    48     344.0     96.1    38     332.6     92.9    44                               
 94       362.0       40       359.1     99.2    46     350.2     96.7    36     330.9     91.4    43                               
 96       365.8       40       365.3     99.9    43     352.1     96.3    36     332.7     91.0    42                               
 98       362.8       39       361.8     99.7    40     349.8     96.4    34     334.6     92.2    41                               
100       365.7       37       362.0     99.0    39     349.8     95.7    33     336.5     92.0    39                               
102       362.5       35       362.3     99.9    38     348.6     96.2    30     335.2     92.5    39                               
104       366.9       33       356.4     97.1    35     348.9     95.1    28     330.2     90.0    37                               
TERM. SAC.            33                         34                       28                       36                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.