Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/13016

Incidence Rates Of Nonneoplastic Lesions By Anatomic Site

NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97
Route: SKIN APPLICATION                                                                                           Time: 07:36:55

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-83-4

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     24           23           31                                                  
    Moribund Sacrifice                                11            9            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           18           14                                                  

  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)                                                
      Foreign Body                                     1 (2%)                                                                       
      Perforation                                                   1 (2%)                                                          
   Intestine Large, Colon                             (47)         (50)         (48)                                                
      Parasite Metazoan                                2 (4%)       3 (6%)       4 (8%)                                             
   Intestine Large, Rectum                            (38)         (47)         (46)                                                
      Parasite Metazoan                                1 (3%)       1 (2%)       2 (4%)                                             
   Intestine Small, Jejunum                           (36)         (38)         (38)                                                
      Inflammation, Chronic Active                                  1 (3%)                                                          
      Necrosis                                                      1 (3%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                18 (36%)     15 (30%)     11 (22%)                                            
      Clear Cell Focus                                              1 (2%)                                                          
      Eosinophilic Focus                                            3 (6%)                                                          
      Hepatodiaphragmatic Nodule                       7 (14%)     14 (28%)     11 (22%)                                            
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic Active                    13 (26%)      7 (14%)      9 (18%)                                            
      Mixed Cell Focus                                 1 (2%)       2 (4%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                        3 (6%)       3 (6%)       2 (4%)                                             
      Bile Duct, Dilatation                                         1 (2%)                                                          
   Mesentery                                          (3)          (3)                                                              
      Fat, Inflammation, Chronic Active                3 (100%)     3 (100%)                                                        
   Pancreas                                           (50)         (50)         (50)                                                
      Fibrosis                                                                   1 (2%)                                             
      Acinus, Atrophy                                  3 (6%)       5 (10%)      1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Hyperkeratosis                                   1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
      Ulcer                                            1 (2%)       5 (10%)      2 (4%)                                             
      Epithelium, Hyperplasia                          1 (2%)       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Chronic Active                    18 (36%)     20 (40%)     14 (28%)                                            
      Thrombosis                                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                                          2 (4%)                                             
      Angiectasis                                     25 (50%)     19 (38%)     26 (52%)                                            
      Degeneration                                     1 (2%)                    1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)                                             
      Mineralization                                                1 (2%)                                                          
      Pigmentation, Lipofuscin                                                   1 (2%)                                             
      Vacuolization Cytoplasmic                        7 (14%)      7 (14%)      4 (8%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Parathyroid Gland                                  (42)         (43)         (42)                                                
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Angiectasis                                      3 (6%)       2 (4%)       4 (8%)                                             
      Cyst                                             8 (16%)      6 (12%)      5 (10%)                                            
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Pars Distalis, Angiectasis                       8 (16%)      2 (4%)       4 (8%)                                             
      Pars Distalis, Hyperplasia                       4 (8%)       4 (8%)       9 (18%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Ultimobranchial Cyst                             2 (4%)       1 (2%)                                                          
      C-Cell, Hyperplasia                              1 (2%)       1 (2%)                                                          
      Follicle, Cyst                                   1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (47)         (50)                                                
      Cyst                                             2 (4%)       2 (4%)       1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic Active                    46 (94%)     44 (94%)     43 (86%)                                            
   Ovary                                              (50)         (50)         (50)                                                
      Atrophy                                                                    1 (2%)                                             
      Congestion                                                    1 (2%)                                                          
      Cyst                                                          3 (6%)                                                          
      Pigmentation, Lipofuscin                                      1 (2%)                                                          
      Follicle, Cyst                                                1 (2%)                                                          
      Periovarian Tissue, Cyst                         3 (6%)       8 (16%)      3 (6%)                                             
   Oviduct                                            (1)                                                                           
      Cyst                                             1 (100%)                                                                     
   Uterus                                             (50)         (50)         (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Hydrometra                                                    4 (8%)       2 (4%)                                             
   Vagina                                             (1)                       (1)                                                 
      Hypertrophy                                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node                                         (2)          (2)          (1)                                                 
      Ectasia                                          1 (50%)                                                                      
      Pigmentation, Hemosiderin                                     1 (50%)                                                         
      Pigmentation, Lipofuscin                                      1 (50%)                                                         
   Lymph Node, Mesenteric                             (50)         (50)         (50)                                                
      Ectasia                                          1 (2%)       1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Accessory Spleen                                 1 (2%)       1 (2%)                                                          
      Fibrosis                                         3 (6%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)         (50)                                                
      Dilatation                                       9 (18%)     11 (22%)      7 (14%)                                            
      Galactocele                                      1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Skin                                               (50)         (50)         (50)                                                
      Sebaceous Gland, Skin, Site of Application,                                                                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
           Hyperplasia                                 2 (4%)      48 (96%)     49 (98%)                                            
      Skin, Site of Application, Hyperkeratosis        1 (2%)      38 (76%)     31 (62%)                                            
      Skin, Site of Application, Hyperplasia           3 (6%)      50 (100%)    50 (100%)                                           
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                              2 (4%)      44 (88%)     48 (96%)                                            
      Skin, Site of Application, Parakeratosis         2 (4%)      27 (54%)     43 (86%)                                            
      Skin, Site of Application, Ulcer                 3 (6%)      20 (40%)     36 (72%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Fibrous Osteodystrophy                                                     1 (2%)                                             
      Osteosclerosis                                   5 (10%)                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                                    2 (4%)       2 (4%)                                             
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic Active                     5 (10%)      3 (6%)       4 (8%)                                             
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)                                             
   Nose                                               (49)         (50)         (50)                                                
      Inflammation, Suppurative                        2 (4%)       2 (4%)       1 (2%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (3)          (6)                                                 
      Mineralization                                   1 (33%)      1 (33%)      1 (17%)                                            
      Retinal Detachment                                            1 (33%)                                                         
      Lens, Cataract                                                             1 (17%)                                            
      Lens, Mineralization                                          1 (33%)      3 (50%)                                            
      Retina, Degeneration                             2 (67%)      3 (100%)     4 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Casts Protein                                    1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Mineralization                                  35 (70%)     37 (74%)     37 (74%)                                            
      Nephropathy                                      9 (18%)      8 (16%)      5 (10%)                                            
      Pigmentation, Hemosiderin                        4 (8%)       3 (6%)                                                          
      Renal Tubule, Degeneration                                    1 (2%)                                                          
      Renal Tubule, Hyperplasia                        2 (4%)       1 (2%)                                                          
      Renal Tubule, Regeneration                       1 (2%)       2 (4%)       2 (4%)                                             
   Urinary Bladder                                    (50)         (49)         (49)                                                
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)                                             
      Mineralization                                                1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     16           10           12                                                  
    Moribund Sacrifice                                26           30           24                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8           10           14                                                  

  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (48)         (49)                                                
      Mineralization                                                3 (6%)       2 (4%)                                             
      Parasite Metazoan                                3 (6%)       1 (2%)       2 (4%)                                             
   Intestine Large, Rectum                            (48)         (49)         (48)                                                
      Mineralization                                                1 (2%)       1 (2%)                                             
      Parasite Metazoan                                2 (4%)                    2 (4%)                                             
   Intestine Large, Cecum                             (38)         (41)         (40)                                                
      Mineralization                                                             1 (3%)                                             
   Intestine Small, Duodenum                          (50)         (50)         (50)                                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                                2 (4%)       2 (4%)                                             
      Ulcer                                                                      2 (4%)                                             
   Intestine Small, Jejunum                           (42)         (45)         (43)                                                
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Ileum                             (41)         (45)         (45)                                                
      Parasite Metazoan                                1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      2 (4%)       2 (4%)       1 (2%)                                             
      Basophilic Focus                                 7 (14%)     11 (22%)      7 (14%)                                            
      Clear Cell Focus                                              2 (4%)       1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Degeneration                                     2 (4%)                                                                       
      Eosinophilic Focus                                            1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       4 (8%)       7 (14%)      5 (10%)                                            
      Inflammation, Chronic Active                     2 (4%)       4 (8%)       2 (4%)                                             
      Mixed Cell Focus                                 3 (6%)       3 (6%)       5 (10%)                                            
      Necrosis                                         2 (4%)                    2 (4%)                                             
      Vacuolization Cytoplasmic                       10 (20%)     12 (24%)     15 (30%)                                            
      Bile Duct, Hyperplasia                           3 (6%)       4 (8%)       2 (4%)                                             
   Mesentery                                          (5)          (7)          (3)                                                 
      Mineralization                                   1 (20%)                                                                      

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Inflammation, Chronic Active                4 (80%)      5 (71%)      2 (67%)                                            
      Fat, Mineralization                                           2 (29%)                                                         
      Fat, Necrosis                                                 1 (14%)      1 (33%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Atrophy                                  3 (6%)       6 (12%)      3 (6%)                                             
      Acinus, Hyperplasia                                           1 (2%)                                                          
      Duct, Hyperplasia                                1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Edema                                            5 (10%)      6 (12%)      3 (6%)                                             
      Hyperkeratosis                                  14 (28%)     26 (52%)     11 (22%)                                            
      Hyperplasia, Basal Cell                          2 (4%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                    12 (24%)     23 (46%)     11 (22%)                                            
      Inflammation, Suppurative                        3 (6%)       3 (6%)       1 (2%)                                             
      Mineralization                                   2 (4%)       1 (2%)       3 (6%)                                             
      Necrosis                                                                   2 (4%)                                             
      Perforation                                      4 (8%)      10 (20%)      1 (2%)                                             
      Ulcer                                           10 (20%)     14 (28%)      7 (14%)                                            
      Epithelium, Hyperplasia                         14 (28%)     25 (50%)     13 (26%)                                            
   Stomach, Glandular                                 (50)         (49)         (50)                                                
      Erosion                                                       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                  13 (26%)      6 (12%)      8 (16%)                                            
      Necrosis                                                      1 (2%)                                                          
      Perforation                                                   1 (2%)                                                          
      Ulcer                                            2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
      Mineralization                                  12 (24%)      5 (10%)      7 (14%)                                            
   Heart                                              (50)         (49)         (50)                                                
      Inflammation, Chronic Active                    35 (70%)     38 (78%)     33 (66%)                                            
      Mineralization                                   7 (14%)      4 (8%)       7 (14%)                                            
      Thrombosis                                       1 (2%)       4 (8%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Angiectasis                                      1 (2%)       2 (4%)       2 (4%)                                             
      Degeneration                                                  1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      4 (8%)                    1 (2%)                                             
      Vacuolization Cytoplasmic                       11 (22%)     23 (46%)     13 (26%)                                            
   Adrenal Medulla                                    (50)         (50)         (49)                                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      2 (4%)       3 (6%)       5 (10%)                                            
      Mineralization                                                1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Hyperplasia                                                   1 (2%)                                                          
   Parathyroid Gland                                  (45)         (47)         (50)                                                
      Hyperplasia                                     17 (38%)     18 (38%)     12 (24%)                                            
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Cyst                                             1 (2%)       2 (4%)       2 (4%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                       2 (4%)                                                                       
      Hyperplasia                                                   2 (4%)       1 (2%)                                             
      Mineralization                                   1 (2%)       2 (4%)       1 (2%)                                             
      Pars Distalis, Angiectasis                       2 (4%)                                                                       
      Pars Distalis, Hyperplasia                       2 (4%)       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Ultimobranchial Cyst                             1 (2%)       1 (2%)                                                          
      C-Cell, Hyperplasia                              1 (2%)                    1 (2%)                                             
      Follicle, Cyst                                                3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (50)         (50)                                                
      Cyst                                             8 (16%)      2 (4%)       1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
      Inflammation, Chronic Active                    32 (64%)     35 (70%)     38 (76%)                                            
      Mineralization                                   1 (2%)                    1 (2%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic Active                    10 (20%)     10 (20%)      7 (14%)                                            
      Inflammation, Suppurative                        1 (2%)       3 (6%)                                                          
      Mineralization                                                1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (50)                                                
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)                                             
      Mineralization                                                2 (4%)                                                          
   Testes                                             (50)         (50)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Degeneration                                    16 (32%)     14 (28%)     11 (22%)                                            
      Mineralization                                   4 (8%)       6 (12%)      5 (10%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Necrosis                                         1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                  28 (56%)     23 (46%)     20 (40%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Hyperplasia                                                   1 (2%)                                                          
      Myelofibrosis                                    2 (4%)                                                                       
   Lymph Node                                         (2)                                                                           
      Ectasia                                          1 (50%)                                                                      
   Lymph Node, Mandibular                             (49)         (49)         (49)                                                
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)                                                          
   Lymph Node, Mesenteric                             (49)         (48)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Ectasia                                          2 (4%)       5 (10%)      5 (10%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Depletion Cellular                                            1 (2%)                                                          
      Fibrosis                                         6 (12%)      6 (12%)      5 (10%)                                            
      Hematopoietic Cell Proliferation                 2 (4%)       6 (12%)      3 (6%)                                             
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Capsule, Hyperplasia                                                       1 (2%)                                             
   Thymus                                             (45)         (42)         (44)                                                
      Atrophy                                          1 (2%)                    2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)         (49)                                                
      Dilatation                                       9 (18%)     16 (33%)     12 (24%)                                            
      Galactocele                                      6 (12%)      8 (16%)     10 (20%)                                            
      Hyperplasia                                      1 (2%)                                                                       
      Mineralization                                   2 (4%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Epidermis, Cyst                                               1 (2%)                                                          
      Sebaceous Gland, Skin, Site of Application,                                                                                   
           Hyperplasia                                 1 (2%)      45 (90%)     45 (90%)                                            
      Skin, Site of Application, Fibrosis                                        1 (2%)                                             
      Skin, Site of Application, Hyperkeratosis                    44 (88%)     40 (80%)                                            
      Skin, Site of Application, Hyperplasia                       49 (98%)     47 (94%)                                            
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic Active                                          48 (96%)     41 (82%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Skin, Site of Application, Mineralization                                  1 (2%)                                             
      Skin, Site of Application, Parakeratosis                     10 (20%)     11 (22%)                                            
      Skin, Site of Application, Ulcer                              7 (14%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)                                                
      Fibrous Osteodystrophy                           9 (18%)     11 (22%)      6 (12%)                                            
   Skeletal Muscle                                                              (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Fibrosis                                                                   2 (4%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                     5 (10%)                   4 (8%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Mineralization                                   5 (10%)      3 (6%)       3 (6%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (2%)       1 (2%)                                             
      Mediastinum, Fibrosis                            1 (2%)                                                                       
      Serosa, Fibrosis                                              1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)                                             
      Inflammation, Suppurative                        4 (8%)                    3 (6%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Chronic Active                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Degeneration                                     1 (50%)                                                                      
      Cornea, Edema                                    1 (50%)                                                                      
      Lens, Mineralization                             1 (50%)                   1 (100%)                                           
      Retina, Degeneration                                                       1 (100%)                                           
   Harderian Gland                                                 (1)                                                              
      Hyperplasia                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 91014-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/25/97  
Route: SKIN APPLICATION                                                                                           Time: 07:36:55  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Accumulation, Hyaline Droplet                                 1 (2%)                                                          
      Casts                                                         1 (2%)                                                          
      Cyst                                             5 (10%)     12 (24%)      4 (8%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                  10 (20%)      5 (10%)      7 (14%)                                            
      Necrosis                                         1 (2%)                                                                       
      Nephropathy                                     40 (80%)     42 (84%)     40 (80%)                                            
      Pigmentation, Hemosiderin                        5 (10%)      5 (10%)      8 (16%)                                            
      Renal Tubule, Degeneration                       2 (4%)       1 (2%)                                                          
      Renal Tubule, Hyperplasia                        1 (2%)                    1 (2%)                                             
      Renal Tubule, Hyperplasia, Oncocytic                          1 (2%)                                                          
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Regeneration                                    1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)                                                
      Calculus Micro Observation Only                               1 (2%)                                                          
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                       3 (6%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)       2 (4%)       1 (2%)                                             
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------