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Incidence Rates of Neoplasms by Anatomic Site

NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97
Route: SKIN APPLICATION                                                                                           Time: 13:31:08




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-83-4

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     24           23           31                                                  
    Moribund Sacrifice                                11            9            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           18           14                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)                                                
      Lipoma                                                        1 (2%)                                                          
   Intestine Small, Duodenum                          (50)         (50)         (50)                                                
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Pancreas                                           (50)         (50)         (50)                                                
   Salivary Glands                                    (50)         (50)         (50)                                                
      Schwannoma Malignant                             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)                                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Pheochromocytoma Benign                          2 (4%)                    1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Adenoma                          26 (52%)     19 (38%)     17 (34%)                                            
      Pars Distalis, Adenoma, Multiple                 3 (6%)       1 (2%)       2 (4%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  3 (6%)       4 (8%)       2 (4%)                                             
      Follicular Cell, Adenoma                                      1 (2%)                                                          

                                                             Page   2                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (47)         (50)                                                
      Adenoma                                          9 (18%)      3 (6%)       4 (8%)                                             
      Carcinoma                                                     1 (2%)       1 (2%)                                             
      Schwannoma Malignant                                          1 (2%)                                                          
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Deciduoma Benign                                                           1 (2%)                                             
      Polyp Stromal                                    1 (2%)       2 (4%)       2 (4%)                                             
   Vagina                                             (1)                       (1)                                                 
      Polyp                                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (2)          (2)          (1)                                                 
   Lymph Node, Mandibular                             (49)         (49)         (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (47)         (46)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)                    3 (6%)                                             
      Fibroadenoma                                     9 (18%)     10 (20%)      6 (12%)                                            
      Mixed Tumor Malignant                                         1 (2%)                                                          

                                                             Page   3                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
   Skin                                               (50)         (50)         (50)                                                
      Melanoma Malignant                               1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                                  1 (2%)       1 (2%)                                             
      Chordoma, Metastatic, Uncertain Primary Site                  1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Lipoma                                                        1 (2%)                                                          
      Renal Tubule, Adenoma, Multiple                                            1 (2%)                                             
   Urinary Bladder                                    (50)         (49)         (49)                                                
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                             5 (10%)      9 (18%)      8 (16%)                                            
      Lymphoma Malignant                                            1 (2%)                                                          
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   4                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
____________________________________________________________________________________________________________________________________

                                                             Page   5                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          34          32                                                   
     Total Primary Neoplasms                           70          61          51                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          28          26                                                   
     Total Benign Neoplasms                            58          45          39                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              12          15          12                                                   
     Total Malignant Neoplasms                         12          16          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1                                                               
     Total Metastatic Neoplasm                                      1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     16           10           12                                                  
    Moribund Sacrifice                                26           30           24                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8           10           14                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (38)         (41)         (40)                                                
   Intestine Small, Duodenum                          (50)         (50)         (50)                                                
   Intestine Small, Jejunum                           (42)         (45)         (43)                                                
      Carcinoma                                                                  1 (2%)                                             
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (41)         (45)         (45)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                                        1 (2%)                                                          
   Mesentery                                          (5)          (7)          (3)                                                 
   Oral Mucosa                                        (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)                                                
      Acinus, Adenoma                                                            1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
      Carcinoma                                                     1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)                                                
   Heart                                              (50)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
   Adrenal Medulla                                    (50)         (50)         (49)                                                
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                          8 (16%)      3 (6%)       3 (6%)                                             
      Bilateral, Pheochromocytoma Benign               4 (8%)       3 (6%)       3 (6%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                    3 (6%)                                             
      Carcinoma                                        2 (4%)       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Pars Distalis, Adenoma                          37 (74%)     38 (76%)     39 (80%)                                            
      Pars Distalis, Adenoma, Multiple                 1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  2 (4%)       5 (10%)      6 (12%)                                            
      C-Cell, Carcinoma                                2 (4%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma                                      4 (8%)       1 (2%)                                             
      Follicular Cell, Carcinoma                                    2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Preputial Gland                                    (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
   Prostate                                           (50)         (50)         (50)                                                
   Seminal Vesicle                                    (50)         (50)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           14 (28%)     16 (32%)     21 (42%)                                            
      Interstitial Cell, Adenoma                      10 (20%)     14 (28%)     16 (32%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
   Lymph Node                                         (2)                                                                           
   Lymph Node, Mandibular                             (49)         (49)         (49)                                                
   Lymph Node, Mesenteric                             (49)         (48)         (50)                                                
   Spleen                                             (50)         (50)         (50)                                                
   Thymus                                             (45)         (42)         (44)                                                
____________________________________________________________________________________________________________________________________

                                                             Page   8                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)         (49)                                                
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                     3 (6%)                    1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                               1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Keratoacanthoma                                  1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibroma                         1 (2%)                                                                       
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Fibrosarcoma                                 1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)                                                
      Vertebra, Chordoma                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Adenoma                            3 (6%)       4 (8%)       1 (2%)                                             
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (50)                                                
      Papilloma                                        1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Granulocytic                            1 (2%)                                                                       
      Leukemia Mononuclear                            14 (28%)     13 (26%)     13 (26%)                                            
      Lymphoma Malignant                               1 (2%)                    1 (2%)                                             
      Mesothelioma Malignant                           2 (4%)       1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 91014-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 11/14/97  
Route: SKIN APPLICATION                                                                                           Time: 13:31:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      50 MG/KG     100MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48          50                                                   
     Total Primary Neoplasms                          117         114         127                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          47          49                                                   
     Total Benign Neoplasms                            90          91          99                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          18          22                                                   
     Total Malignant Neoplasms                         27          23          28                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          1                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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