National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10628

Incidence Rates Of Neoplasms By Anatomic Site

NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97
Route: SKIN APPLICATION                                                                                           Time: 09:41:47

                                                         2 YEAR CHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-83-4

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25023 Missing
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    15 MG/KG
                               Include 006    30 MG/KG
                               Include 001    0 MG/KG
                               Include 003    15 MG/KG
                               Include 005    30 MG/KG



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          55           55           55                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8           12            8                                                  
    Natural Death                                      8            8            6                                                  
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           30           35                                                  

  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (46)         (49)                                                
   Intestine Large, Colon                             (50)         (50)         (50)                                                
   Intestine Large, Cecum                             (50)         (50)         (50)                                                
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (49)         (50)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatoblastoma                                   1 (2%)                                                                       
      Hepatocellular Carcinoma                         4 (8%)       8 (16%)      7 (14%)                                            
      Hepatocellular Carcinoma, Multiple               1 (2%)       2 (4%)                                                          
      Hepatocellular Adenoma                          12 (24%)     13 (26%)     10 (20%)                                            
      Hepatocellular Adenoma, Multiple                14 (28%)     17 (34%)     18 (36%)                                            
      Histiocytic Sarcoma                              3 (6%)       2 (4%)       1 (2%)                                             
      Ito Cell Tumor Benign, Multiple                               1 (2%)                                                          
   Mesentery                                          (12)         (7)          (9)                                                 
      Hemangioma                                                                 1 (11%)                                            
      Sarcoma                                          1 (8%)                                                                       
   Pancreas                                           (49)         (50)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          2 (4%)       2 (4%)       4 (8%)                                             
      Squamous Cell Papilloma, Multiple                1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)                                                
   Adrenal Medulla                                    (50)         (50)         (50)                                                
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (49)         (50)         (50)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Adenoma                           9 (18%)      6 (12%)      3 (6%)                                             
      Pars Intermedia, Adenoma                                      3 (6%)       1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (50)         (50)                                                
      Cystadenoma                                      3 (6%)       2 (4%)                                                          
      Granulosa Cell Tumor Benign                                                1 (2%)                                             
      Hemangioma                                                    1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Luteoma                                                                    1 (2%)                                             
      Teratoma Benign                                               2 (4%)                                                          
      Periovarian Tissue, Plasma Cell Tumor                                                                                         
          Malignant, Metastatic, Lymph Node,                                                                                        
          Mesenteric                                                             1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Hemangioma                                                    2 (4%)                                                          
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                                                          
      Leiomyoma                                                     1 (2%)                                                          
      Polyp Stromal                                    1 (2%)       2 (4%)                                                          
      Sarcoma Stromal                                  1 (2%)                                                                       
      Cervix, Histiocytic Sarcoma                      1 (2%)                                                                       
   Vagina                                                          (1)                                                              
____________________________________________________________________________________________________________________________________

                                                             Page   3                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (2)          (5)          (8)                                                 
      Lumbar, Histiocytic Sarcoma                      1 (50%)                                                                      
      Renal, Fibrosarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                                                 1 (13%)                                            
   Lymph Node, Mandibular                             (49)         (49)         (47)                                                
      Hemangioma                                       1 (2%)                                                                       
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Lymph Node, Mesenteric                                                1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (47)         (49)                                                
      Plasma Cell Tumor Malignant                                                1 (2%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (41)         (45)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Fibrosarcoma                                     1 (2%)       1 (2%)       2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Pinna, Melanoma Malignant                                     1 (2%)                                                          
      Skin, Site of Application, Fibrosarcoma          1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (1)                       (1)                                                 
      Fibrosarcoma                                                               1 (100%)                                           
      Osteosarcoma                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       3 (6%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       2 (4%)       3 (6%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       4 (8%)       6 (12%)                                            
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Lymph Node, Mesenteric                                                1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (2)                                                              
      Adenoma                                          3 (100%)     1 (50%)                                                         
      Carcinoma                                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Plasma Cell Tumor Malignant, Metastatic,                                                                                      
           Lymph Node, Mesenteric                                                1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              3 (6%)       2 (4%)       1 (2%)                                             
      Leukemia Granulocytic                            1 (2%)                                                                       
      Lymphoma Malignant                               3 (6%)       9 (18%)     11 (22%)                                            
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          45          36                                                   
     Total Primary Neoplasms                           77          86          72                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          40          31                                                   
     Total Benign Neoplasms                            53          56          46                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          23          21                                                   
     Total Malignant Neoplasms                         24          30          26                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           5           8                                                   
     Total Metastatic Neoplasm                          4           5          11                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          55           55           55                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            8           11                                                  
    Natural Death                                      5            7            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           35           34                                                  
  Missing                                              1                                                                            

  Animals Examined Microscopically                    49           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (48)         (50)         (50)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (50)         (50)                                                
      Carcinoma                                        2 (4%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                   2 (4%)                                                          
   Intestine Small, Ileum                             (49)         (50)         (50)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
   Liver                                              (49)         (50)         (50)                                                
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Hemangiosarcoma                                               2 (4%)       1 (2%)                                             
      Hemangiosarcoma, Multiple                        1 (2%)       2 (4%)       1 (2%)                                             
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         5 (10%)      9 (18%)     12 (24%)                                            
      Hepatocellular Carcinoma, Multiple               4 (8%)                    1 (2%)                                             
      Hepatocellular Adenoma                          13 (27%)     14 (28%)     14 (28%)                                            
      Hepatocellular Adenoma, Multiple                 9 (18%)      8 (16%)      8 (16%)                                            
      Hepatocholangiocarcinoma                                      2 (4%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (4)          (4)          (3)                                                 
      Fibrous Histiocytoma, Metastatic, Liver          1 (25%)                                                                      
   Pancreas                                           (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
   Salivary Glands                                    (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (50)         (50)                                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       2 (4%)                                                          
   Stomach, Glandular                                 (49)         (50)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
   Heart                                              (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)                                                
      Adenoma                                          2 (4%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
   Adrenal Medulla                                    (49)         (50)         (50)                                                
   Islets, Pancreatic                                 (49)         (50)         (50)                                                
      Adenoma                                                       2 (4%)       2 (4%)                                             
   Thyroid Gland                                      (49)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
      Follicular Cell, Adenoma                         2 (4%)                    1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
   Preputial Gland                                    (48)         (50)         (50)                                                
      Hemangioma                                                    1 (2%)                                                          
   Prostate                                           (49)         (50)         (50)                                                
   Seminal Vesicle                                    (49)         (50)         (50)                                                
   Testes                                             (49)         (50)         (50)                                                
      Hemangioma                                                                 1 (2%)                                             
      Interstitial Cell, Adenoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Hemangiosarcoma                                                            2 (4%)                                             
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
   Lymph Node                                         (3)          (4)          (1)                                                 
      Lumbar, Fibrous Histiocytoma, Metastatic,                                                                                     
           Liver                                       1 (33%)                                                                      
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (25%)                                                         
      Pancreatic, Hepatocellular Carcinoma,                                                                                         
          Metastatic, Liver                            1 (33%)                                                                      
      Renal, Fibrous Histiocytoma, Metastatic,                                                                                      
           Liver                                       1 (33%)                                                                      
   Lymph Node, Mandibular                             (48)         (46)         (47)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
   Lymph Node, Mesenteric                             (47)         (48)         (48)                                                
   Spleen                                             (49)         (50)         (50)                                                
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  3 (6%)       4 (8%)       2 (4%)                                             
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
   Thymus                                             (45)         (36)         (39)                                                
      Hemangioma                                                                 1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (50)                                                
      Fibrosarcoma                                                               1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
      Schwannoma Benign                                             1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     6 (12%)      8 (16%)      4 (8%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      8 (16%)      9 (18%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       2 (4%)                                                          
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       2 (4%)       5 (10%)                                            
      Hepatocholangiocarcinoma, Metastatic, Liver                   2 (4%)       3 (6%)                                             
      Mediastinum, Hemangioma                                                    1 (2%)                                             
   Nose                                               (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (5)                                                 
      Adenoma                                          2 (100%)     1 (100%)     4 (80%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Liver          1 (2%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(49)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant                               1 (2%)       6 (12%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 91014-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:41:47  
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         B6C3F1 MICE MALE                          0 MG/KG      15 MG/KG     30 MG/KG                                               
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          43          44                                                   
     Total Primary Neoplasms                           61          77          74                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28          30          32                                                   
     Total Benign Neoplasms                            35          39          40                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          29          25                                                   
     Total Malignant Neoplasms                         26          38          34                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           6           9                                                   
     Total Metastatic Neoplasm                         18          16          11                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.