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https://ntp.niehs.nih.gov/go/7680

Nonneoplastic Lesions By Individual Animal

NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97
Route: SKIN APPLICATION                                                                                           Time: 09:37:41

                                                          14 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-83-4

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    15 MG/KG
                               Include 006    30 MG/KG
                               Include 001    0 MG/KG
                               Include 003    15 MG/KG
                               Include 005    30 MG/KG































                                                              Page   1


NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 2| 2|                                                           |      A     |
    0 MG/KG                                | 9| 9| 9| 0| 1|                                                           |      L     |
                                           | 4| 8| 9| 0| 8|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +                                                               |   1        |
      Follicle, Cyst                       |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   2                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    15 MG/KG                               | 3| 4| 6| 6| 7|                                                           |      L     |
                                           | 7| 2| 3| 4| 4|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation, Chronic Active    |    1  1  1  1                                                            |      4  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 1  1  1  1  1                                                            |      5  1.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 1  1  1  1  1                                                            |      5  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   |       1     1                                                            |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   3                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    15 MG/KG                               | 3| 4| 6| 6| 7|                                                           |      L     |
                                           | 7| 2| 3| 4| 4|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   4                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3|                                                           |      A     |
    30 MG/KG                               | 8| 8| 0| 1| 2|                                                           |      L     |
                                           | 7| 9| 4| 5| 8|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation, Chronic Active    | 1  1  1  1                                                               |      4  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 1  1  1  1                                                               |      4  1.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 1  1  1  1  1                                                            |      5  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   | 1     1  1                                                               |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   5                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3|                                                           |      A     |
    30 MG/KG                               | 8| 8| 0| 1| 2|                                                           |      L     |
                                           | 7| 9| 4| 5| 8|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   6                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 0| 1| 2| 4| 4|                                                           |      L     |
                                           | 2| 8| 6| 0| 4|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   7                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    15 MG/KG                               | 6| 7| 8| 9| 9|                                                           |      L     |
                                           | 2| 0| 4| 3| 6|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation, Chronic Active    | 1  1  1  1  1                                                            |      5  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 1  1  2  1  1                                                            |      5  1.2|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Parakeratosis                   |       1                                                                  |      1  1.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 1  1  1  1  1                                                            |      5  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   | 1  1  1     1                                                            |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   8                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    15 MG/KG                               | 6| 7| 8| 9| 9|                                                           |      L     |
                                           | 2| 0| 4| 3| 6|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   9                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    30 MG/KG                               | 3| 3| 5| 6| 6|                                                           |      L     |
                                           | 2| 3| 9| 2| 3|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation, Chronic Active    | 2  1  2  2  1                                                            |      5  1.6|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     | 2  2  2  2  2                                                            |      5  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Inflammation, Suppurative       |       1                                                                  |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Parakeratosis                   | 1     1  1  1                                                            |      4  1.0|
      Sebaceous Gland, Skin, Site of       |                                                                          |            |
          Application, Hyperplasia         | 1  1  1  1  1                                                            |      5  1.0|
      Skin, Site of Application,           |                                                                          |            |
          Hyperkeratosis                   |    1  1  1  1                                                            |      4  1.0|
      Skin, Site of Application, Ulcer     | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  10                                                               
NTP Experiment-Test: 91014-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                OLEIC ACID DIETHANOLAMINE CONDENSATE                           Date: 09/23/97  
Route: SKIN APPLICATION                                                                                           Time: 09:37:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0|                                                           |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9|                                                           |            |
                                           | 4| 4| 4| 4| 4|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    30 MG/KG                               | 3| 3| 5| 6| 6|                                                           |      L     |
                                           | 2| 3| 9| 2| 3|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  11                                                               
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