National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9118

TDMS Study 92012-05 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 03/14/03       
EXPERIMENT: 92012 TEST: 05                                                                                     TIME: 10:41:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 693-98-1        
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                                                        FINAL#1; REVISION#1                                                         
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 03/14/03       
EXPERIMENT: 92012 TEST: 05                                                                                     TIME: 10:41:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 693-98-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                   2-METHYLIMIDAZOLE                                                                              
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
                                       Hemorrhage                                                                                   
Bone Marrow: Myeloid Cell              Hyperplasia                                                                                  
Harderian Gland: Epithelium            Hyperplasia Focal                                                                            
Heart                                  Cardiomyopathy                                                                               
Liver                                  Basophilic Focus                                                                             
                                       Hematopoietic Cell Proliferation                                                             
                                       Infiltration Cellular Mixed Cell                                                             
                                       Inflammation Granulomatous                                                                   
                                       Mixed Cell Focus                                                                             
Liver: Hepatocyte, Centrilobular       Vacuolization Cytoplasmic                                                                    
Lung                                   Hyperplasia Focal Histiocytic                                                                
                                       Metaplasia Osseous                                                                           
Lung: Alveolar Epithelium              Hyperplasia Focal                                                                            
Lymph Node: Pancreatic                 Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Mammary Gland                          Dilatation                                                                                   
                                       Hyperplasia                                                                                  
Mesentery                              Hemorrhage                                                                                   
Mesentery: Fat                         Necrosis Focal                                                                               
Nose: Nasolacrimal Duct                Inflammation                                                                                 
Pancreas: Acinus                       Atrophy Focal                                                                                
Pancreas: Duct                         Cyst Focal                                                                                   
Preputial Gland                        Degeneration Cystic                                                                          
                                       Inflammation Chronic                                                                         
Spleen                                 Inflammation Granulomatous                                                                   
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular                     Erosion                                                                                      
                                       Ulcer                                                                                        
Testes                                 Atrophy                                                                                      
Testes: Bilateral, Interstitial Cell   Hyperplasia Focal                                                                            
Testes: Interstitial Cell              Hyperplasia Focal                                                                            
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone Marrow                            Hyperplasia Focal Histiocytic                                                                
Clitoral Gland                         Degeneration Cystic                                                                          
Kidney                                 Nephropathy                                                                                  
Kidney: Renal Tubule                   Accumulation, Hyaline Droplet                                                                
                                       Pigmentation                                                                                 
Liver                                  Basophilic Focus                                                                             
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Infarct                                                                                      
                                       Infiltration Cellular Mixed Cell                                                             
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                2-METHYLIMIDAZOLE                                   DATE: 03/14/03       
EXPERIMENT: 92012 TEST: 05                                                                                     TIME: 10:41:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92012B       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 693-98-1        
                                       Inflammation Granulomatous                                                                   
                                       Mixed Cell Focus                                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
Lung                                   Hyperplasia                                                                                  
                                       Infiltration Cellular Mixed Cell                                                             
Lymph Node, Mesenteric                 Ectasia                                                                                      
                                       Pigmentation                                                                                 
Lymph Node: Mediastinal                Hemorrhage                                                                                   
Lymph Node: Pancreatic                 Ectasia                                                                                      
                                       Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
Mammary Gland                          Dilatation                                                                                   
Mesentery: Fat                         Necrosis Focal                                                                               
Nose: Nasolacrimal Duct                Inflammation                                                                                 
Ovary                                  Cyst                                                                                         
Pituitary Gland: Pars Distalis         Degeneration Cystic Focal                                                                    
                                       Hemorrhage Focal                                                                             
Pituitary Gland: Pars Intermedia       Cyst                                                                                         
Pituitary Gland: Rathke's Cleft        Hemorrhage                                                                                   
Salivary Glands: Duct                  Mineralization Focal                                                                         
Skin                                   Necrosis Focal                                                                               
Spleen                                 Inflammation Granulomatous                                                                   
Stomach, Glandular: Glands             Hyperplasia Focal                                                                            
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicle                Mineralization Focal                                                                         
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
Urinary Bladder: Transitional Epithelium                                                                                            
                                       Hyperplasia                                                                                  
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    9/50 (18%)   5/50 (10%)  |2/50 (4%)    2/49 (4%)    5/50 (10%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     1/46.41      4/45.93      9/44.49      5/44.51     |2/46.00      2/44.59      5/43.58      5/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         8.7%         20.2%        11.2%       |4.4%         4.5%         11.5%        10.4%        | 
|TERMINAL (d)       |     0/35 (0%)    4/40 (10%)   9/36 (25%)   3/35 (9%)   |2/40 (5%)    2/39 (5%)    1/28 (4%)    5/42 (12%)   | 
|FIRST INCIDENCE    |     651          729 (T)      729 (T)      598         |729 (T)      729 (T)      244          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187      P=0.213      P=0.011 *    P=0.101     |P=0.124      P=0.686      P=0.156      P=0.236      | 
|POLY 3             |     P=0.186      P=0.175      P=0.006 **   P=0.092     |P=0.124      P=0.683      P=0.194      P=0.234      | 
|POLY 1.5           |     P=0.195      P=0.178      P=0.007 **   P=0.095     |P=0.118      P=0.684      P=0.205      P=0.228      | 
|POLY 6             |     P=0.181      P=0.174      P=0.006 **   P=0.090     |P=0.131      P=0.683      P=0.179      P=0.243      | 
|LOGISTIC REGRESSION|     P=0.189      P=0.178      P=0.008 **   P=0.107     |P=0.076      P=0.686      P=0.421      P=0.236      | 
|COCH-ARM / FISHERS |     P=0.218      P=0.181      P=0.008 **   P=0.102     |P=0.108      P=0.684      P=0.218      P=0.218      | 
|ORDER RESTRICTED   |     P=0.021 *    (e)          (e)          (e)         |P=0.174      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/49 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      0/43.91     |1/46.00      1/44.92      1/41.10      2/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         2.2%         2.4%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |1/40 (3%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      638          638          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.371      P=0.757      P=0.707      P=0.517      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.365      P=0.755      P=0.735      P=0.515      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.359      P=0.755      P=0.745      P=0.509      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.371      P=0.757      P=0.722      P=0.522      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.348      P=0.760      P=0.765N     P=0.517      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.351      P=0.747      P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.437      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |3/50 (6%)    0/49 (0%)    1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     2/46.41      1/45.93      1/45.22      3/44.80     |3/46.28      0/44.59      1/41.26      5/48.35      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         2.2%         6.7%        |6.5%         0.0%         2.4%         10.3%        | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    0/36 (0%)    1/35 (3%)   |2/40 (5%)    0/39 (0%)    0/28 (0%)    4/42 (10%)   | 
|FIRST INCIDENCE    |     651          729 (T)      471          598         |653          ---          580          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.262      P=0.472N     P=0.507N     P=0.480     |P=0.118      P=0.129N     P=0.409N     P=0.391      | 
|POLY 3             |     P=0.271      P=0.504N     P=0.509N     P=0.484     |P=0.104      P=0.125N     P=0.347N     P=0.381      | 
|POLY 1.5           |     P=0.273      P=0.502N     P=0.506N     P=0.489     |P=0.101      P=0.124N     P=0.331N     P=0.372      | 
|POLY 6             |     P=0.269      P=0.505N     P=0.512N     P=0.481     |P=0.107      P=0.126N     P=0.369N     P=0.393      | 
|LOGISTIC REGRESSION|     P=0.348      P=0.500N     P=0.460N     P=0.540     |P=0.098      P=0.124N     P=0.281N     P=0.351      | 
|COCH-ARM / FISHERS |     P=0.280      P=0.500N     P=0.500N     P=0.500     |P=0.100      P=0.125N     P=0.309N     P=0.357      | 
|ORDER RESTRICTED   |     P=0.277      (e)          (e)          (e)         |P=0.068      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/49 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.41      0/45.93      0/44.49      0/43.91     |0/46.00      1/44.92      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     651          ---          ---          ---         |---          638          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.254N     P=0.227N     P=0.244N     P=0.250N    |P=0.511N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.240N     P=0.240N     P=0.247N     P=0.250N    |P=0.532N     P=0.495      (e)          (e)          | 
|POLY 1.5           |     P=0.241N     P=0.238N     P=0.243N     P=0.245N    |P=0.530N     P=0.495      (e)          (e)          | 
|POLY 6             |     P=0.240N     P=0.240N     P=0.250N     P=0.254N    |P=0.533N     P=0.496      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.238N     P=0.239N     P=0.233N     P=0.233N    |P=0.539N     P=0.497      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.242N     P=0.247N     P=0.247N     P=0.247N    |P=0.525N     P=0.495      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.034N*    (e)          (e)          (e)         |P=0.368N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   9/50 (18%)   10/50 (20%)  10/50 (20%) |8/50 (16%)   3/49 (6%)    7/50 (14%)   12/50 (24%)  | 
|POLY-3 RATE (b)    |     6/46.13      9/45.93      10/44.49     10/44.22    |8/46.00      3/44.59      7/41.34      12/48.54     | 
|POLY-3 PERCENT (g) |     13.0%        19.6%        22.5%        22.6%       |17.4%        6.7%         16.9%        24.7%        | 
|TERMINAL (d)       |     6/35 (17%)   9/40 (23%)   10/36 (28%)  8/35 (23%)  |8/40 (20%)   3/39 (8%)    5/28 (18%)   10/42 (24%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      689         |729 (T)      729 (T)      638          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      P=0.387      P=0.217      P=0.202     |P=0.069      P=0.106N     P=0.450      P=0.271      | 
|POLY 3             |     P=0.220      P=0.283      P=0.182      P=0.178     |P=0.063      P=0.108N     P=0.589N     P=0.268      | 
|POLY 1.5           |     P=0.231      P=0.287      P=0.191      P=0.187     |P=0.058      P=0.107N     P=0.555N     P=0.251      | 
|POLY 6             |     P=0.213      P=0.283      P=0.176      P=0.173     |P=0.070      P=0.107N     P=0.595      P=0.293      | 
|LOGISTIC REGRESSION|     P=0.193      P=0.387      P=0.217      P=0.165     |P=0.070      P=0.106N     P=0.560      P=0.270      | 
|COCH-ARM / FISHERS |     P=0.258      P=0.288      P=0.207      P=0.207     |P=0.054      P=0.106N     P=0.500N     P=0.227      | 
|ORDER RESTRICTED   |     P=0.193      (e)          (e)          (e)         |P=0.066      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   3/50 (6%)    7/50 (14%)  |1/49 (2%)    1/49 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     7/46.82      5/45.93      3/44.49      7/44.18     |1/45.00      1/44.59      1/40.77      2/48.02      | 
|POLY-3 PERCENT (g) |     15.0%        10.9%        6.7%         15.9%       |2.2%         2.2%         2.5%         4.2%         | 
|TERMINAL (d)       |     3/35 (9%)    5/40 (13%)   3/36 (8%)    5/35 (14%)  |1/39 (3%)    1/39 (3%)    1/28 (4%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     643          729 (T)      729 (T)      687         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.390      P=0.327N     P=0.167N     P=0.587     |P=0.368      P=0.762      P=0.686      P=0.526      | 
|POLY 3             |     P=0.402      P=0.393N     P=0.179N     P=0.568     |P=0.371      P=0.759      P=0.738      P=0.523      | 
|POLY 1.5           |     P=0.413      P=0.386N     P=0.170N     P=0.584     |P=0.365      P=0.759      P=0.749      P=0.517      | 
|POLY 6             |     P=0.392      P=0.401N     P=0.187N     P=0.552     |P=0.378      P=0.759      P=0.724      P=0.530      | 
|LOGISTIC REGRESSION|     P=0.391      P=0.381N     P=0.169N     P=0.582     |P=0.368      P=0.762      P=0.686      P=0.526      | 
|COCH-ARM / FISHERS |     P=0.435      P=0.380N     P=0.159N     P=0.613N    |P=0.355      P=0.753N     P=0.747N     P=0.508      | 
|ORDER RESTRICTED   |     P=0.375      (e)          (e)          (e)         |P=0.447      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/47 (2%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/46.13      1/45.93      1/42.59      0/43.91     |0/45.49      1/44.99      0/40.77      4/48.18      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.4%         0.0%        |0.0%         2.2%         0.0%         8.3%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    1/35 (3%)    0/35 (0%)   |0/40 (0%)    1/39 (3%)    0/28 (0%)    3/42 (7%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          729 (T)      ---          689          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.550N     P=0.527      P=0.500      (e)         |P=0.020 *    P=0.495      (e)          P=0.074      | 
|POLY 3             |     P=0.548N     P=0.499      P=0.484      (e)         |P=0.014 *    P=0.498      (e)          P=0.068      | 
|POLY 1.5           |     P=0.544N     P=0.500      P=0.485      (e)         |P=0.014 *    P=0.500      (e)          P=0.066      | 
|POLY 6             |     P=0.551N     P=0.499      P=0.484      (e)         |P=0.014 *    P=0.496      (e)          P=0.071      | 
|LOGISTIC REGRESSION|     (e)          P=0.527      P=0.500      (e)         |P=0.019 *    P=0.495      (e)          P=0.069      | 
|COCH-ARM / FISHERS |     P=0.536N     P=0.500      P=0.485      (e)         |P=0.015 *    P=0.505      (e)          P=0.061      | 
|ORDER RESTRICTED   |     P=0.394      (e)          (e)          (e)         |P=0.007 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Myeloid Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/47 (0%)    5/50 (10%)  |2/49 (4%)    3/50 (6%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.13      1/45.93      0/42.59      5/44.23     |2/45.49      3/45.44      5/41.00      2/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         11.3%       |4.4%         6.6%         12.2%        4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/35 (0%)    3/35 (9%)   |2/40 (5%)    2/39 (5%)    4/28 (14%)   2/42 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          687         |729 (T)      598          668          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.527      (e)          P=0.034 *   |P=0.559N     P=0.487      P=0.105      P=0.677N     | 
|POLY 3             |     P=0.002 **   P=0.499      (e)          P=0.027 *   |P=0.546N     P=0.500      P=0.176      P=0.674N     | 
|POLY 1.5           |     P=0.002 **   P=0.500      (e)          P=0.028 *   |P=0.555N     P=0.503      P=0.194      P=0.679N     | 
|POLY 6             |     P=0.002 **   P=0.499      (e)          P=0.026 *   |P=0.534N     P=0.498      P=0.155      P=0.668N     | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.527      (e)          P=0.029 *   |P=0.553N     P=0.508      P=0.138      P=0.677N     | 
|COCH-ARM / FISHERS |     P=0.003 **   P=0.500      (e)          P=0.028 *   |P=0.570N     P=0.510      P=0.226      P=0.684N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.393      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Myeloid Cell, Erythroid Cell                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/47 (0%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/42.59      0/43.91     |0/45.49      2/44.99      1/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.5%         2.5%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/35 (0%)    0/35 (0%)   |0/40 (0%)    2/39 (5%)    1/28 (4%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.422N     P=0.233      P=0.429      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.415N     P=0.235      P=0.478      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.417N     P=0.238      P=0.488      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.412N     P=0.232      P=0.465      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.233      P=0.429      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.420N     P=0.253      P=0.505      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.300N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |10/50 (20%)  8/49 (16%)   12/50 (24%)  4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/46.26      2/45.93      4/46.05      1/43.91     |10/47.20     8/45.91      12/43.24     4/48.36      | 
|POLY-3 PERCENT (g) |     8.7%         4.4%         8.7%         2.3%        |21.2%        17.4%        27.8%        8.3%         | 
|TERMINAL (d)       |     3/35 (9%)    2/40 (5%)    1/36 (3%)    1/35 (3%)   |6/40 (15%)   5/39 (13%)   5/28 (18%)   2/42 (5%)    | 
|FIRST INCIDENCE    |     694          729 (T)      392          729 (T)     |602          425          532          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.219N     P=0.290N     P=0.638N     P=0.187N    |P=0.103N     P=0.421N     P=0.189      P=0.068N     | 
|POLY 3             |     P=0.216N     P=0.341N     P=0.641      P=0.195N    |P=0.080N     P=0.422N     P=0.315      P=0.066N     | 
|POLY 1.5           |     P=0.210N     P=0.339N     P=0.641      P=0.190N    |P=0.085N     P=0.418N     P=0.348      P=0.068N     | 
|POLY 6             |     P=0.222N     P=0.341N     P=0.642      P=0.200N    |P=0.075N     P=0.427N     P=0.277      P=0.063N     | 
|LOGISTIC REGRESSION|     P=0.170N     P=0.334N     P=0.601N     P=0.198N    |P=0.100N     P=0.405N     P=0.426      P=0.085N     | 
|COCH-ARM / FISHERS |     P=0.196N     P=0.339N     P=0.643N     P=0.181N    |P=0.094N     P=0.416N     P=0.405      P=0.074N     | 
|ORDER RESTRICTED   |     P=0.160N     (e)          (e)          (e)         |P=0.053N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |2/50 (4%)    1/49 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.89      3/47.22      2/45.29      1/44.36     |2/46.59      1/45.39      2/41.66      0/48.02      | 
|POLY-3 PERCENT (g) |     4.3%         6.4%         4.4%         2.3%        |4.3%         2.2%         4.8%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     603          521          583          598         |583          425          548          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.331N     P=0.487      P=0.668      P=0.536N    |P=0.209N     P=0.513N     P=0.621      P=0.232N     | 
|POLY 3             |     P=0.323N     P=0.503      P=0.681      P=0.519N    |P=0.201N     P=0.509N     P=0.653      P=0.231N     | 
|POLY 1.5           |     P=0.316N     P=0.503      P=0.686      P=0.513N    |P=0.204N     P=0.508N     P=0.669      P=0.233N     | 
|POLY 6             |     P=0.330N     P=0.505      P=0.679      P=0.526N    |P=0.197N     P=0.510N     P=0.633      P=0.228N     | 
|LOGISTIC REGRESSION|     P=0.181N     P=0.462      P=0.656N     P=0.430N    |P=0.209N     P=0.500N     P=0.605N     P=0.282N     | 
|COCH-ARM / FISHERS |     P=0.300N     P=0.500      P=0.691N     P=0.500N    |P=0.207N     P=0.508N     P=0.691N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.380N     (e)          (e)          (e)         |P=0.150N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.46      1/46.44      0/44.49      0/43.91     |0/46.00      0/44.59      2/41.66      0/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         0.0%        |0.0%         0.0%         4.8%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     638          572          ---          ---         |---          ---          548          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318N     P=0.748      P=0.513N     P=0.527N    |P=0.584      (e)          P=0.212      (e)          | 
|POLY 3             |     P=0.307N     P=0.760      P=0.509N     P=0.511N    |P=0.611      (e)          P=0.216      (e)          | 
|POLY 1.5           |     P=0.306N     P=0.760N     P=0.505N     P=0.507N    |P=0.598      (e)          P=0.224      (e)          | 
|POLY 6             |     P=0.309N     P=0.760N     P=0.511N     P=0.515N    |P=0.625      (e)          P=0.206      (e)          | 
|LOGISTIC REGRESSION|     P=0.239N     P=0.729      P=0.483N     P=0.472N    |P=0.559      (e)          P=0.305      (e)          | 
|COCH-ARM / FISHERS |     P=0.303N     P=0.753N     P=0.500N     P=0.500N    |P=0.576      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.262N     (e)          (e)          (e)         |P=0.228      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   4/49 (8%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |6/46.39      4/43.99      1/41.10      1/48.02      | 
|POLY-3 PERCENT (g) |                                                        |12.9%        9.1%         2.4%         2.1%         | 
|TERMINAL (d)       |                                                        |5/40 (13%)   4/38 (11%)   0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |                                                        |616          729 (T)      638          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.024N*    P=0.401N     P=0.122N     P=0.052N     | 
|POLY 3             |                                                        |P=0.019N*    P=0.403N     P=0.078N     P=0.051N     | 
|POLY 1.5           |                                                        |P=0.020N*    P=0.395N     P=0.069N     P=0.053N     | 
|POLY 6             |                                                        |P=0.019N*    P=0.411N     P=0.091N     P=0.048N*    | 
|LOGISTIC REGRESSION|                                                        |P=0.021N*    P=0.399N     P=0.067N     P=0.056N     | 
|COCH-ARM / FISHERS |                                                        |P=0.022N*    P=0.383N     P=0.056N     P=0.056N     | 
|ORDER RESTRICTED   |                                                        |P=0.019N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    4/49 (8%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/46.00      4/43.99      3/40.84      1/48.02      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         9.1%         7.3%         2.1%         | 
|TERMINAL (d)       |                                                        |1/40 (3%)    4/38 (11%)   2/28 (7%)    1/42 (2%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      710          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.390N     P=0.164      P=0.193      P=0.751N     | 
|POLY 3             |                                                        |P=0.377N     P=0.165      P=0.264      P=0.751N     | 
|POLY 1.5           |                                                        |P=0.386N     P=0.168      P=0.280      P=0.755N     | 
|POLY 6             |                                                        |P=0.366N     P=0.163      P=0.245      P=0.746N     | 
|LOGISTIC REGRESSION|                                                        |P=0.371N     P=0.164      P=0.217      P=0.751N     | 
|COCH-ARM / FISHERS |                                                        |P=0.398N     P=0.175      P=0.309      P=0.753N     | 
|ORDER RESTRICTED   |                                                        |P=0.285N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    5/49 (10%)   4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/46.00      5/43.99      4/41.43      0/48.02      | 
|POLY-3 PERCENT (g) |                                                        |4.4%         11.4%        9.7%         0.0%         | 
|TERMINAL (d)       |                                                        |2/40 (5%)    5/38 (13%)   1/28 (4%)    0/42 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      665          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.121N     P=0.195      P=0.223      P=0.228N     | 
|POLY 3             |                                                        |P=0.103N     P=0.198      P=0.290      P=0.228N     | 
|POLY 1.5           |                                                        |P=0.109N     P=0.202      P=0.308      P=0.232N     | 
|POLY 6             |                                                        |P=0.096N     P=0.195      P=0.271      P=0.223N     | 
|LOGISTIC REGRESSION|                                                        |P=0.113N     P=0.195      P=0.300      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.119N     P=0.210      P=0.339      P=0.247N     | 
|ORDER RESTRICTED   |                                                        |P=0.059N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    1/46 (2%)    0/50 (0%)   |1/50 (2%)    2/49 (4%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.14      0/45.93      1/41.09      0/43.91     |1/46.00      2/44.59      2/40.53      1/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.4%         0.0%        |2.2%         4.5%         4.9%         2.1%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    1/35 (3%)    0/35 (0%)   |1/40 (3%)    2/39 (5%)    1/28 (4%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |729 (T)      729 (T)      548          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476N     P=0.473N     P=0.762      P=0.500N    |P=0.534N     P=0.491      P=0.408      P=0.751N     | 
|POLY 3             |     P=0.470N     P=0.497N     P=0.740      P=0.506N    |P=0.526N     P=0.489      P=0.456      P=0.751N     | 
|POLY 1.5           |     P=0.467N     P=0.496N     P=0.742      P=0.502N    |P=0.533N     P=0.491      P=0.470      P=0.755N     | 
|POLY 6             |     P=0.473N     P=0.496N     P=0.740      P=0.508N    |P=0.518N     P=0.489      P=0.439      P=0.746N     | 
|LOGISTIC REGRESSION|     P=0.476N     (e)          P=0.762      (e)         |P=0.540N     P=0.491      P=0.518      P=0.751N     | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.495N     P=0.737      P=0.495N    |P=0.542N     P=0.492      P=0.492      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.256N     (e)          (e)          (e)         |P=0.500N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/46 (2%)    0/50 (0%)   |0/50 (0%)    2/49 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.14      0/45.93      1/41.09      0/43.91     |0/46.00      2/44.59      1/39.96      1/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         0.0%        |0.0%         4.5%         2.5%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/35 (3%)    0/35 (0%)   |0/40 (0%)    2/39 (5%)    1/28 (4%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.795N     (e)          P=0.500      (e)         |P=0.532      P=0.233      P=0.429      P=0.510      | 
|POLY 3             |     P=0.789N     (e)          P=0.481      (e)         |P=0.546      P=0.230      P=0.472      P=0.509      | 
|POLY 1.5           |     P=0.787N     (e)          P=0.483      (e)         |P=0.539      P=0.231      P=0.481      P=0.505      | 
|POLY 6             |     P=0.791N     (e)          P=0.481      (e)         |P=0.556      P=0.230      P=0.461      P=0.513      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.500      (e)         |(e)          P=0.233      P=0.429      P=0.510      | 
|COCH-ARM / FISHERS |     P=0.782N     (e)          P=0.484      (e)         |P=0.528      P=0.242      P=0.495      P=0.500      | 
|ORDER RESTRICTED   |     P=0.364      (e)          (e)          (e)         |P=0.248      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    2/50 (4%)   |2/50 (4%)    0/49 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.13      1/46.35      0/43.72      2/45.03     |2/46.86      0/44.59      1/41.67      1/48.35      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         4.4%        |4.3%         0.0%         2.4%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          605          ---          491         |602          ---          332          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141      P=0.496      (e)          P=0.228     |P=0.509N     P=0.252N     P=0.535N     P=0.476N     | 
|POLY 3             |     P=0.148      P=0.501      (e)          P=0.232     |P=0.517N     P=0.248N     P=0.541N     P=0.489N     | 
|POLY 1.5           |     P=0.149      P=0.501      (e)          P=0.233     |P=0.520N     P=0.246N     P=0.524N     P=0.493N     | 
|POLY 6             |     P=0.147      P=0.502      (e)          P=0.231     |P=0.514N     P=0.251N     P=0.564N     P=0.484N     | 
|LOGISTIC REGRESSION|     P=0.241      P=0.454      (e)          P=0.304     |P=0.586N     P=0.237N     P=0.285N     P=0.612N     | 
|COCH-ARM / FISHERS |     P=0.152      P=0.500      (e)          P=0.247     |P=0.524N     P=0.253N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.071      (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)   |1/50 (2%)    2/49 (4%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/43.72      1/43.91     |1/46.00      2/44.59      1/40.77      4/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |2.2%         4.5%         2.5%         8.3%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    1/35 (3%)   |1/40 (3%)    2/39 (5%)    1/28 (4%)    4/42 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      (e)          (e)          P=0.500     |P=0.131      P=0.491      P=0.680      P=0.194      | 
|POLY 3             |     P=0.208      (e)          (e)          P=0.490     |P=0.124      P=0.489      P=0.733      P=0.192      | 
|POLY 1.5           |     P=0.210      (e)          (e)          P=0.493     |P=0.121      P=0.491      P=0.744      P=0.187      | 
|POLY 6             |     P=0.206      (e)          (e)          P=0.487     |P=0.127      P=0.489      P=0.719      P=0.199      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.500     |P=0.131      P=0.491      P=0.680      P=0.194      | 
|COCH-ARM / FISHERS |     P=0.215      (e)          (e)          P=0.500     |P=0.118      P=0.492      P=0.753N     P=0.181      | 
|ORDER RESTRICTED   |     P=0.111      (e)          (e)          (e)         |P=0.106      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/49 (4%)    3/50 (6%)   |0/50 (0%)    0/49 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.13      0/45.93      2/43.72      3/43.91     |0/46.00      0/44.59      3/40.96      1/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.6%         6.8%        |0.0%         0.0%         7.3%         2.1%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    2/36 (6%)    3/35 (9%)   |0/40 (0%)    0/39 (0%)    2/28 (7%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |---          ---          680          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.091      P=0.473N     P=0.510      P=0.305     |P=0.251      (e)          P=0.074      P=0.510      | 
|POLY 3             |     P=0.095      P=0.501N     P=0.481      P=0.288     |P=0.259      (e)          P=0.099      P=0.509      | 
|POLY 1.5           |     P=0.098      P=0.500N     P=0.485      P=0.294     |P=0.248      (e)          P=0.107      P=0.505      | 
|POLY 6             |     P=0.092      P=0.501N     P=0.480      P=0.283     |P=0.271      (e)          P=0.091      P=0.513      | 
|LOGISTIC REGRESSION|     P=0.091      (e)          P=0.510      P=0.305     |P=0.248      (e)          P=0.092      P=0.510      | 
|COCH-ARM / FISHERS |     P=0.105      P=0.500N     P=0.492      P=0.309     |P=0.233      (e)          P=0.121      P=0.500      | 
|ORDER RESTRICTED   |     P=0.098      (e)          (e)          (e)         |P=0.097      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland: Epithelium                                                                                                      | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    2/49 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.32      0/45.93      0/43.72      1/43.91     |0/46.00      2/44.59      2/40.77      1/48.02      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         0.0%         2.3%        |0.0%         4.5%         4.9%         2.1%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    0/36 (0%)    1/35 (3%)   |0/40 (0%)    2/39 (5%)    2/28 (7%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     694          ---          ---          729 (T)     |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.473N     P=0.115N     P=0.125N     P=0.324N    |P=0.496      P=0.233      P=0.164      P=0.510      | 
|POLY 3             |     P=0.452N     P=0.120N     P=0.129N     P=0.325N    |P=0.516      P=0.230      P=0.211      P=0.509      | 
|POLY 1.5           |     P=0.451N     P=0.119N     P=0.127N     P=0.318N    |P=0.506      P=0.231      P=0.221      P=0.505      | 
|POLY 6             |     P=0.453N     P=0.121N     P=0.131N     P=0.331N    |P=0.528      P=0.230      P=0.199      P=0.513      | 
|LOGISTIC REGRESSION|     P=0.465N     P=0.121N     P=0.129N     P=0.325N    |(e)          P=0.233      P=0.164      P=0.510      | 
|COCH-ARM / FISHERS |     P=0.448N     P=0.121N     P=0.125N     P=0.309N    |P=0.491      P=0.242      P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.044N*    (e)          (e)          (e)         |P=0.204      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   10/50 (20%)  5/50 (10%)  |5/50 (10%)   8/49 (16%)   7/50 (14%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     3/47.05      5/47.56      10/45.29     5/44.84     |5/46.00      8/44.70      7/41.42      6/48.02      | 
|POLY-3 PERCENT (g) |     6.4%         10.5%        22.1%        11.2%       |10.9%        17.9%        16.9%        12.5%        | 
|TERMINAL (d)       |     2/35 (6%)    2/40 (5%)    8/36 (22%)   3/35 (9%)   |5/40 (13%)   7/39 (18%)   5/28 (18%)   6/42 (14%)   | 
|FIRST INCIDENCE    |     315          521          548          562         |729 (T)      702          548          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400      P=0.392      P=0.042 *    P=0.348     |P=0.543N     P=0.260      P=0.178      P=0.534      | 
|POLY 3             |     P=0.387      P=0.363      P=0.029 *    P=0.330     |P=0.528N     P=0.257      P=0.307      P=0.530      | 
|POLY 1.5           |     P=0.402      P=0.359      P=0.030 *    P=0.337     |P=0.541N     P=0.259      P=0.334      P=0.518      | 
|POLY 6             |     P=0.378      P=0.371      P=0.028 *    P=0.328     |P=0.511N     P=0.257      P=0.274      P=0.545      | 
|LOGISTIC REGRESSION|     P=0.522      P=0.371      P=0.042 *    P=0.427     |P=0.517N     P=0.259      P=0.276      P=0.534      | 
|COCH-ARM / FISHERS |     P=0.442      P=0.357      P=0.036 *    P=0.357     |P=0.551      P=0.264      P=0.380      P=0.500      | 
|ORDER RESTRICTED   |     P=0.102      (e)          (e)          (e)         |P=0.397      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      2/46.12      1/44.75     |0/46.00      0/44.59      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          392          395         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.346      (e)          P=0.242      P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.337      (e)          P=0.237      P=0.494     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.341      (e)          P=0.238      P=0.496     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.333      (e)          P=0.237      P=0.492     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.672      (e)          P=0.183      P=0.644     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.350      (e)          P=0.247      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.167      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    4/49 (8%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.13      1/46.18      0/44.49      0/43.91     |0/46.00      4/45.63      3/41.01      2/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |0.0%         8.8%         7.3%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    2/39 (5%)    2/28 (7%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     ---          660          ---          ---         |---          483          665          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.588N     P=0.500      (e)          (e)         |P=0.439      P=0.065      P=0.076      P=0.249      | 
|POLY 3             |     P=0.578N     P=0.500      (e)          (e)         |P=0.449      P=0.059      P=0.099      P=0.247      | 
|POLY 1.5           |     P=0.577N     P=0.500      (e)          (e)         |P=0.439      P=0.059      P=0.107      P=0.243      | 
|POLY 6             |     P=0.578N     P=0.501      (e)          (e)         |P=0.463      P=0.060      P=0.091      P=0.252      | 
|LOGISTIC REGRESSION|     P=0.557N     P=0.488      (e)          (e)         |P=0.413      P=0.060      P=0.097      P=0.249      | 
|COCH-ARM / FISHERS |     P=0.576N     P=0.500      (e)          (e)         |P=0.423      P=0.056      P=0.121      P=0.247      | 
|ORDER RESTRICTED   |     P=0.390N     (e)          (e)          (e)         |P=0.097      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      2/45.35      1/44.49      1/43.91     |0/46.00      0/44.59      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.3%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    1/36 (3%)    1/35 (3%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.602      P=0.268      P=0.506      P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.601      P=0.233      P=0.493      P=0.490     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.608      P=0.233      P=0.495      P=0.493     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.596      P=0.234      P=0.491      P=0.487     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.268      P=0.506      P=0.500     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.621      P=0.242      P=0.500      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.269      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    2/48 (4%)    1/47 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.14      0/45.35      0/43.72      1/44.36     |0/46.00      2/43.78      1/38.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |0.0%         4.6%         2.6%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    2/39 (5%)    1/28 (4%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          598         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.209      (e)          (e)          P=0.487     |P=0.422N     P=0.233      P=0.429      (e)          | 
|POLY 3             |     P=0.212      (e)          (e)          P=0.497     |P=0.412N     P=0.226      P=0.466      (e)          | 
|POLY 1.5           |     P=0.213      (e)          (e)          P=0.499     |P=0.417N     P=0.227      P=0.474      (e)          | 
|POLY 6             |     P=0.210      (e)          (e)          P=0.495     |P=0.406N     P=0.227      P=0.456      (e)          | 
|LOGISTIC REGRESSION|     P=0.265      (e)          (e)          P=0.549     |(e)          P=0.233      P=0.429      (e)          | 
|COCH-ARM / FISHERS |     P=0.217      (e)          (e)          P=0.505     |P=0.422N     P=0.237      P=0.485      (e)          | 
|ORDER RESTRICTED   |     P=0.116      (e)          (e)          (e)         |P=0.291N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    2/47 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.66      1/45.49      0/43.72      0/43.91     |0/46.00      0/43.78      2/38.99      0/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         0.0%        |0.0%         0.0%         5.1%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     572          693          ---          ---         |---          ---          701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.317N     P=0.756      P=0.517N     P=0.513N    |P=0.583      (e)          P=0.184      (e)          | 
|POLY 3             |     P=0.304N     P=0.760      P=0.509N     P=0.508N    |P=0.610      (e)          P=0.202      (e)          | 
|POLY 1.5           |     P=0.303N     P=0.760      P=0.505N     P=0.504N    |P=0.598      (e)          P=0.210      (e)          | 
|POLY 6             |     P=0.306N     P=0.760      P=0.511N     P=0.512N    |P=0.624      (e)          P=0.193      (e)          | 
|LOGISTIC REGRESSION|     P=0.256N     P=0.737      P=0.482N     P=0.439N    |P=0.577      (e)          P=0.206      (e)          | 
|COCH-ARM / FISHERS |     P=0.299N     P=0.753N     P=0.500N     P=0.495N    |P=0.576      (e)          P=0.232      (e)          | 
|ORDER RESTRICTED   |     P=0.258N     (e)          (e)          (e)         |P=0.215      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/49 (4%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/47 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.14      2/45.35      0/43.72      2/43.91     |0/46.00      0/43.78      0/38.77      1/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         4.6%        |0.0%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    0/36 (0%)    2/35 (6%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.269      P=0.268      (e)          P=0.238     |P=0.208      (e)          (e)          P=0.510      | 
|POLY 3             |     P=0.281      P=0.238      (e)          P=0.231     |P=0.204      (e)          (e)          P=0.509      | 
|POLY 1.5           |     P=0.285      P=0.238      (e)          P=0.235     |P=0.202      (e)          (e)          P=0.505      | 
|POLY 6             |     P=0.278      P=0.239      (e)          P=0.228     |P=0.208      (e)          (e)          P=0.513      | 
|LOGISTIC REGRESSION|     (e)          P=0.268      (e)          P=0.238     |(e)          (e)          (e)          P=0.510      | 
|COCH-ARM / FISHERS |     P=0.294      P=0.247      (e)          P=0.253     |P=0.197      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.111      (e)          (e)          (e)         |P=0.129      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     43/49 (88%)  43/49 (88%)  41/49 (84%)  46/50 (92%) |38/50 (76%)  40/48 (83%)  38/47 (81%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     43/47.99     43/47.27     41/46.03     46/49.61    |38/47.91     40/45.15     38/45.05     40/48.46     | 
|POLY-3 PERCENT (g) |     89.6%        91.0%        89.1%        92.7%       |79.3%        88.6%        84.4%        82.5%        | 
|TERMINAL (d)       |     33/35 (94%)  39/40 (98%)  35/36 (97%)  32/35 (91%) |32/40 (80%)  37/39 (95%)  25/28 (89%)  38/42 (91%)  | 
|FIRST INCIDENCE    |     315          507          538          249         |602          483          244          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.099      P=0.180N     P=0.352N     P=0.308     |P=0.526      P=0.318      P=0.023 *    P=0.592N     | 
|POLY 3             |     P=0.370      P=0.552      P=0.606N     P=0.422     |P=0.533      P=0.163      P=0.354      P=0.442      | 
|POLY 1.5           |     P=0.320      P=0.581      P=0.530N     P=0.389     |P=0.506      P=0.201      P=0.372      P=0.433      | 
|POLY 6             |     P=0.460      P=0.520      P=0.651      P=0.488     |P=0.550      P=0.126      P=0.314      P=0.442      | 
|LOGISTIC REGRESSION|     P=0.167      P=0.608N     P=0.504N     P=0.348     |P=0.523      P=0.183      P=0.283      P=0.587      | 
|COCH-ARM / FISHERS |     P=0.274      P=0.620N     P=0.387N     P=0.357     |P=0.449      P=0.259      P=0.370      P=0.405      | 
|ORDER RESTRICTED   |     P=0.447      (e)          (e)          (e)         |P=0.328      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    3/49 (6%)    2/50 (4%)   |11/50 (22%)  7/48 (15%)   3/47 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     1/45.47      1/45.77      3/44.59      2/44.97     |11/46.39     7/44.56      3/39.66      4/48.18      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         6.7%         4.5%        |23.7%        15.7%        7.6%         8.3%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/36 (3%)    0/35 (0%)   |10/40 (25%)  5/39 (13%)   0/28 (0%)    3/42 (7%)    | 
|FIRST INCIDENCE    |     638          605          471          249         |616          598          598          689          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.376      P=0.748      P=0.301      P=0.481     |P=0.028N*    P=0.239N     P=0.082N     P=0.038N*    | 
|POLY 3             |     P=0.390      P=0.759N     P=0.298      P=0.496     |P=0.021N*    P=0.244N     P=0.040N*    P=0.036N*    | 
|POLY 1.5           |     P=0.398      P=0.759N     P=0.301      P=0.501     |P=0.022N*    P=0.246N     P=0.035N*    P=0.040N*    | 
|POLY 6             |     P=0.381      P=0.758N     P=0.298      P=0.491     |P=0.020N*    P=0.237N     P=0.046N*    P=0.033N*    | 
|LOGISTIC REGRESSION|     P=0.579      P=0.732      P=0.336      P=0.642     |P=0.023N*    P=0.250N     P=0.037N*    P=0.038N*    | 
|COCH-ARM / FISHERS |     P=0.408      P=0.753N     P=0.309      P=0.508     |P=0.024N*    P=0.247N     P=0.027N*    P=0.045N*    | 
|ORDER RESTRICTED   |     P=0.321      (e)          (e)          (e)         |P=0.014N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   3/49 (6%)    2/49 (4%)    3/50 (6%)   |8/50 (16%)   4/48 (8%)    5/47 (11%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/46.11      3/46.61      2/44.32      3/45.42     |8/48.92      4/45.75      5/40.28      0/48.02      | 
|POLY-3 PERCENT (g) |     10.8%        6.4%         4.5%         6.6%        |16.4%        8.7%         12.4%        0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/36 (3%)    0/35 (0%)   |2/40 (5%)    0/39 (0%)    1/28 (4%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     638          548          538          249         |328          483          526          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.431N     P=0.370N     P=0.239N     P=0.395N    |P=0.009N**   P=0.207N     P=0.416N     P=0.005N**   | 
|POLY 3             |     P=0.403N     P=0.351N     P=0.233N     P=0.365N    |P=0.007N**   P=0.212N     P=0.413N     P=0.004N**   | 
|POLY 1.5           |     P=0.395N     P=0.352N     P=0.226N     P=0.356N    |P=0.007N**   P=0.208N     P=0.378N     P=0.004N**   | 
|POLY 6             |     P=0.413N     P=0.348N     P=0.239N     P=0.375N    |P=0.007N**   P=0.214N     P=0.453N     P=0.004N**   | 
|LOGISTIC REGRESSION|     P=0.234N     P=0.379N     P=0.191N     P=0.239N    |P=0.005N**   P=0.076N     P=0.145N     P=0.006N**   | 
|COCH-ARM / FISHERS |     P=0.384N     P=0.357N     P=0.218N     P=0.346N    |P=0.007N**   P=0.199N     P=0.318N     P=0.003N**   | 
|ORDER RESTRICTED   |     P=0.260N     (e)          (e)          (e)         |P=0.002N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/49 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      1/44.49      0/43.91     |2/46.00      1/44.59      2/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.4%         2.2%         4.9%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/36 (3%)    0/35 (0%)   |2/40 (5%)    1/39 (3%)    2/28 (7%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.795N     (e)          P=0.506      (e)         |P=0.214N     P=0.509N     P=0.561      P=0.228N     | 
|POLY 3             |     P=0.793N     (e)          P=0.493      (e)         |P=0.196N     P=0.511N     P=0.650      P=0.228N     | 
|POLY 1.5           |     P=0.791N     (e)          P=0.495      (e)         |P=0.201N     P=0.509N     P=0.667      P=0.232N     | 
|POLY 6             |     P=0.795N     (e)          P=0.491      (e)         |P=0.191N     P=0.511N     P=0.627      P=0.223N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.506      (e)         |P=0.214N     P=0.509N     P=0.561      (e)          | 
|COCH-ARM / FISHERS |     P=0.786N     (e)          P=0.500      (e)         |P=0.207N     P=0.508N     P=0.691N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.374      (e)          (e)          (e)         |P=0.148N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  23/50 (46%)  8/50 (16%)   2/50 (4%)   |42/50 (84%)  44/49 (90%)  43/50 (86%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     23/46.14     23/45.93     8/44.49      2/43.91     |42/47.88     44/48.07     43/47.40     39/48.69     | 
|POLY-3 PERCENT (g) |     49.9%        50.1%        18.0%        4.6%        |87.7%        91.5%        90.7%        80.1%        | 
|TERMINAL (d)       |     22/35 (63%)  23/40 (58%)  8/36 (22%)   2/35 (6%)   |38/40 (95%)  38/39 (97%)  28/28 (100%) 36/42 (86%)  | 
|FIRST INCIDENCE    |     726          729 (T)      729 (T)      729 (T)     |328          425          244          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P=0.320N     P<0.001N**   P<0.001N**  |P=0.143N     P=0.285      P=0.002 **   P=0.142N     | 
|POLY 3             |     P<0.001N**   P=0.575      P<0.001N**   P<0.001N**  |P=0.085N     P=0.381      P=0.437      P=0.218N     | 
|POLY 1.5           |     P<0.001N**   P=0.579      P<0.001N**   P<0.001N**  |P=0.114N     P=0.336      P=0.463      P=0.261N     | 
|POLY 6             |     P<0.001N**   P=0.577      P<0.001N**   P<0.001N**  |P=0.047N*    P=0.454      P=0.409      P=0.156N     | 
|LOGISTIC REGRESSION|     (e)          P=0.320N     P<0.001N**   P<0.001N**  |P=0.108N     P=0.264      P=0.326      P=0.185N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.579N     P<0.001N**   P<0.001N**  |P=0.145N     P=0.290      P=0.500      P=0.306N     | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.084N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      2/46.06      1/44.36     |0/46.00      0/44.59      2/41.20      1/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         2.3%        |0.0%         0.0%         4.9%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          392          598         |---          ---          665          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.343      (e)          P=0.240      P=0.487     |P=0.257      (e)          P=0.197      P=0.510      | 
|POLY 3             |     P=0.333      (e)          P=0.237      P=0.492     |P=0.256      (e)          P=0.213      P=0.509      | 
|POLY 1.5           |     P=0.338      (e)          P=0.237      P=0.495     |P=0.247      (e)          P=0.222      P=0.505      | 
|POLY 6             |     P=0.330      (e)          P=0.237      P=0.491     |P=0.266      (e)          P=0.203      P=0.513      | 
|LOGISTIC REGRESSION|     P=0.574      (e)          P=0.203      P=0.547     |P=0.230      (e)          P=0.245      P=0.510      | 
|COCH-ARM / FISHERS |     P=0.350      (e)          P=0.247      P=0.500     |P=0.234      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.167      (e)          (e)          (e)         |P=0.149      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    2/50 (4%)    7/50 (14%)  |0/50 (0%)    1/49 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/46.80      3/45.93      2/44.81      7/44.06     |0/46.00      1/44.59      0/40.77      2/48.02      | 
|POLY-3 PERCENT (g) |     8.6%         6.5%         4.5%         15.9%       |0.0%         2.2%         0.0%         4.2%         | 
|TERMINAL (d)       |     1/35 (3%)    3/40 (8%)    1/36 (3%)    6/35 (17%)  |0/40 (0%)    1/39 (3%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     638          729 (T)      641          689         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.084      P=0.462N     P=0.352N     P=0.249     |P=0.164      P=0.495      (e)          P=0.249      | 
|POLY 3             |     P=0.088      P=0.510N     P=0.357N     P=0.227     |P=0.154      P=0.494      (e)          P=0.247      | 
|POLY 1.5           |     P=0.092      P=0.505N     P=0.350N     P=0.239     |P=0.152      P=0.495      (e)          P=0.243      | 
|POLY 6             |     P=0.084      P=0.516N     P=0.364N     P=0.215     |P=0.157      P=0.494      (e)          P=0.252      | 
|LOGISTIC REGRESSION|     P=0.090      P=0.500N     P=0.323N     P=0.241     |(e)          P=0.495      (e)          P=0.249      | 
|COCH-ARM / FISHERS |     P=0.102      P=0.500N     P=0.339N     P=0.262     |P=0.150      P=0.495      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.087      (e)          (e)          (e)         |P=0.080      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    6/50 (12%)   1/50 (2%)   |0/50 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/46.31      0/45.93      6/44.49      1/43.91     |0/46.00      0/44.59      1/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         13.5%        2.3%        |0.0%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    6/36 (17%)   1/35 (3%)   |0/40 (0%)    0/39 (0%)    1/28 (4%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     696          ---          729 (T)      729 (T)     |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.449N     P=0.112N     P=0.254      P=0.320N    |P=0.674      (e)          P=0.429      (e)          | 
|POLY 3             |     P=0.449N     P=0.120N     P=0.222      P=0.325N    |P=0.707      (e)          P=0.476      (e)          | 
|POLY 1.5           |     P=0.439N     P=0.119N     P=0.230      P=0.318N    |P=0.697      (e)          P=0.485      (e)          | 
|POLY 6             |     P=0.460N     P=0.121N     P=0.216      P=0.331N    |P=0.718      (e)          P=0.464      (e)          | 
|LOGISTIC REGRESSION|     P=0.452N     P=0.121N     P=0.222      P=0.325N    |(e)          (e)          P=0.429      (e)          | 
|COCH-ARM / FISHERS |     P=0.418N     P=0.121N     P=0.243      P=0.309N    |P=0.680      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.258      (e)          (e)          (e)         |P=0.361      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/49 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      0/43.91     |0/46.00      2/45.15      1/41.38      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          598          532          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.417N     P=0.232      P=0.487      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.412N     P=0.233      P=0.479      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.416N     P=0.233      P=0.487      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.235      P=0.469      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.442N     P=0.235      P=0.611      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.422N     P=0.242      P=0.500      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.301N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      2/44.87     |0/46.00      0/44.59      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    1/35 (3%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          249         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          (e)          P=0.240     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.039 *    (e)          (e)          P=0.231     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.040 *    (e)          (e)          P=0.234     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.039 *    (e)          (e)          P=0.228     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.096      (e)          (e)          P=0.325     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.027 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      0/43.91     |2/46.00      0/44.59      0/40.77      2/48.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         4.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |2/40 (5%)    0/39 (0%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.486      P=0.244N     P=0.320N     P=0.672N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.482      P=0.244N     P=0.265N     P=0.676N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.479      P=0.243N     P=0.254N     P=0.683N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.486      P=0.244N     P=0.280N     P=0.666N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.482      (e)          (e)          P=0.693      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.476      P=0.253N     P=0.247N     P=0.691N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.267N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   4/50 (8%)    9/50 (18%)  |6/50 (12%)   11/49 (22%)  14/50 (28%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     6/46.41      5/46.13      4/44.72      9/45.27     |6/46.39      11/45.23     14/44.95     13/48.02     | 
|POLY-3 PERCENT (g) |     12.9%        10.8%        8.9%         19.9%       |12.9%        24.3%        31.2%        27.1%        | 
|TERMINAL (d)       |     4/35 (11%)   4/40 (10%)   3/36 (8%)    6/35 (17%)  |5/40 (13%)   9/39 (23%)   6/28 (21%)   13/42 (31%)  | 
|FIRST INCIDENCE    |     668          675          668          491         |616          598          332          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.122      P=0.433N     P=0.367N     P=0.282     |P=0.098      P=0.136      P=0.013 *    P=0.079      | 
|POLY 3             |     P=0.134      P=0.504N     P=0.393N     P=0.269     |P=0.087      P=0.128      P=0.030 *    P=0.071      | 
|POLY 1.5           |     P=0.136      P=0.501N     P=0.385N     P=0.274     |P=0.082      P=0.129      P=0.033 *    P=0.067      | 
|POLY 6             |     P=0.132      P=0.505N     P=0.399N     P=0.266     |P=0.093      P=0.129      P=0.026 *    P=0.076      | 
|LOGISTIC REGRESSION|     P=0.135      P=0.503N     P=0.392N     P=0.288     |P=0.068      P=0.129      P=0.071      P=0.082      | 
|COCH-ARM / FISHERS |     P=0.144      P=0.500N     P=0.370N     P=0.288     |P=0.074      P=0.133      P=0.039 *    P=0.062      | 
|ORDER RESTRICTED   |     P=0.157      (e)          (e)          (e)         |P=0.043 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Focal Lymphoid                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.26      0/45.93      2/44.49      1/44.45     |0/46.00      0/44.59      1/40.88      1/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.5%         2.3%        |0.0%         0.0%         2.5%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    2/36 (6%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     694          ---          729 (T)      562         |---          ---          702          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.533      P=0.505N     P=0.504      P=0.744     |P=0.243      (e)          P=0.444      P=0.510      | 
|POLY 3             |     P=0.535      P=0.501N     P=0.486      P=0.752     |P=0.244      (e)          P=0.476      P=0.509      | 
|POLY 1.5           |     P=0.539      P=0.501N     P=0.492      P=0.754     |P=0.238      (e)          P=0.486      P=0.505      | 
|POLY 6             |     P=0.531      P=0.502N     P=0.483      P=0.750     |P=0.251      (e)          P=0.465      P=0.513      | 
|LOGISTIC REGRESSION|     P=0.571      P=0.501N     P=0.486      P=0.731N    |P=0.238      (e)          P=0.483      P=0.510      | 
|COCH-ARM / FISHERS |     P=0.552      P=0.500N     P=0.500      P=0.753N    |P=0.227      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.365      (e)          (e)          (e)         |P=0.229      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      0/43.91     |0/46.00      0/44.59      0/40.77      2/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.054      (e)          (e)          P=0.249      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.243      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.252      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.249      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.033 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/50 (50%)  30/50 (60%)  27/50 (54%)  36/50 (72%) |42/50 (84%)  44/49 (90%)  34/50 (68%)  38/50 (76%)  | 
|POLY-3 RATE (b)    |     25/47.41     30/46.76     27/46.41     36/46.74    |42/47.88     44/48.26     34/45.77     38/48.85     | 
|POLY-3 PERCENT (g) |     52.7%        64.2%        58.2%        77.0%       |87.7%        91.2%        74.3%        77.8%        | 
|TERMINAL (d)       |     22/35 (63%)  28/40 (70%)  23/36 (64%)  29/35 (83%) |37/40 (93%)  37/39 (95%)  24/28 (86%)  34/42 (81%)  | 
|FIRST INCIDENCE    |     315          548          392          395         |588          425          244          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   P=0.440      P=0.464      P=0.018 *   |P=0.068N     P=0.306      P=0.272      P=0.120N     | 
|POLY 3             |     P=0.013 *    P=0.174      P=0.372      P=0.009 **  |P=0.035N*    P=0.408      P=0.065N     P=0.146N     | 
|POLY 1.5           |     P=0.015 *    P=0.187      P=0.388      P=0.011 *   |P=0.044N*    P=0.367      P=0.052N     P=0.172N     | 
|POLY 6             |     P=0.012 *    P=0.168      P=0.365      P=0.008 **  |P=0.026N*    P=0.447      P=0.100N     P=0.117N     | 
|LOGISTIC REGRESSION|     P=0.012 *    P=0.196      P=0.387      P=0.012 *   |P=0.042N*    P=0.257      P=0.113N     P=0.111N     | 
|COCH-ARM / FISHERS |     P=0.024 *    P=0.211      P=0.421      P=0.020 *   |P=0.064N     P=0.290      P=0.050N     P=0.227N     | 
|ORDER RESTRICTED   |     P=0.007 **   (e)          (e)          (e)         |P=0.043N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  11/50 (22%)  4/50 (8%)    11/50 (22%) |18/50 (36%)  23/49 (47%)  22/50 (44%)  42/50 (84%)  | 
|POLY-3 RATE (b)    |     12/46.49     11/45.93     4/44.49      11/45.57    |18/47.62     23/46.15     22/44.73     42/49.01     | 
|POLY-3 PERCENT (g) |     25.8%        24.0%        9.0%         24.1%       |37.8%        49.8%        49.2%        85.7%        | 
|TERMINAL (d)       |     10/35 (29%)  11/40 (28%)  4/36 (11%)   8/35 (23%)  |14/40 (35%)  19/39 (49%)  11/28 (39%)  36/42 (86%)  | 
|FIRST INCIDENCE    |     668          729 (T)      729 (T)      491         |588          483          496          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.533      P=0.370N     P=0.025N*    P=0.515N    |P<0.001 **   P=0.194      P=0.059      P<0.001 **   | 
|POLY 3             |     P=0.539N     P=0.514N     P=0.031N*    P=0.522N    |P<0.001 **   P=0.165      P=0.184      P<0.001 **   | 
|POLY 1.5           |     P=0.538N     P=0.506N     P=0.029N*    P=0.517N    |P<0.001 **   P=0.173      P=0.212      P<0.001 **   | 
|POLY 6             |     P=0.538N     P=0.521N     P=0.033N*    P=0.524N    |P<0.001 **   P=0.161      P=0.158      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.549      P=0.488N     P=0.032N*    P=0.517N    |P<0.001 **   P=0.180      P=0.251      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.528N     P=0.500N     P=0.027N*    P=0.500N    |P<0.001 **   P=0.184      P=0.270      P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.214N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  16/50 (32%)  23/50 (46%)  26/50 (52%) |15/50 (30%)  14/49 (29%)  11/50 (22%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     14/46.26     16/46.13     23/44.49     26/44.56    |15/47.48     14/44.78     11/41.22     26/48.35     | 
|POLY-3 PERCENT (g) |     30.3%        34.7%        51.7%        58.4%       |31.6%        31.3%        26.7%        53.8%        | 
|TERMINAL (d)       |     13/35 (37%)  15/40 (38%)  23/36 (64%)  23/35 (66%) |12/40 (30%)  13/39 (33%)  10/28 (36%)  25/42 (60%)  | 
|FIRST INCIDENCE    |     696          675          729 (T)      618         |328          680          598          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.577      P=0.043 *    P=0.009 **  |P=0.012 *    P=0.531N     P=0.573      P=0.035 *    | 
|POLY 3             |     P=0.002 **   P=0.408      P=0.028 *    P=0.005 **  |P=0.007 **   P=0.575N     P=0.393N     P=0.021 *    | 
|POLY 1.5           |     P=0.003 **   P=0.412      P=0.034 *    P=0.006 **  |P=0.007 **   P=0.559N     P=0.335N     P=0.020 *    | 
|POLY 6             |     P=0.002 **   P=0.409      P=0.022 *    P=0.004 **  |P=0.008 **   P=0.585N     P=0.467N     P=0.023 *    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.437      P=0.029 *    P=0.004 **  |P=0.014 *    P=0.532N     P=0.327N     P=0.023 *    | 
|COCH-ARM / FISHERS |     P=0.007 **   P=0.414      P=0.048 *    P=0.012 *   |P=0.009 **   P=0.526N     P=0.247N     P=0.021 *    | 
|ORDER RESTRICTED   |     P=0.003 **   (e)          (e)          (e)         |P=0.006 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/49 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.64      0/45.93      2/44.59      1/44.36     |0/46.00      1/44.78      0/40.77      1/48.33      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         4.5%         2.3%        |0.0%         2.2%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/36 (3%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     638          ---          703          598         |---          680          ---          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.617N     P=0.252N     P=0.682      P=0.529N    |P=0.446      P=0.505      (e)          P=0.517      | 
|POLY 3             |     P=0.608N     P=0.241N     P=0.678      P=0.518N    |P=0.438      P=0.495      (e)          P=0.510      | 
|POLY 1.5           |     P=0.605N     P=0.239N     P=0.684      P=0.512N    |P=0.433      P=0.495      (e)          P=0.506      | 
|POLY 6             |     P=0.611N     P=0.243N     P=0.672      P=0.523N    |P=0.444      P=0.495      (e)          P=0.515      | 
|LOGISTIC REGRESSION|     P=0.564N     P=0.247N     P=0.688N     P=0.451N    |P=0.414      P=0.498      (e)          P=0.453      | 
|COCH-ARM / FISHERS |     P=0.596N     P=0.247N     P=0.691N     P=0.500N    |P=0.427      P=0.495      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.434N     (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      2/44.49      0/43.91     |0/46.00      0/44.59      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    2/36 (6%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.711N     (e)          P=0.244      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.714N     (e)          P=0.229      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.709N     (e)          P=0.232      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.718N     (e)          P=0.227      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.244      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.697N     (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/49 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      1/43.91     |2/46.00      0/44.59      1/40.77      1/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |4.4%         0.0%         2.5%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    1/35 (3%)   |2/40 (5%)    0/39 (0%)    1/28 (4%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      (e)          (e)          P=0.500     |P=0.519N     P=0.244N     P=0.624N     P=0.483N     | 
|POLY 3             |     P=0.207      (e)          (e)          P=0.490     |P=0.519N     P=0.244N     P=0.542N     P=0.485N     | 
|POLY 1.5           |     P=0.209      (e)          (e)          P=0.493     |P=0.522N     P=0.243N     P=0.525N     P=0.491N     | 
|POLY 6             |     P=0.205      (e)          (e)          P=0.487     |P=0.516N     P=0.244N     P=0.563N     P=0.478N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.500     |P=0.519N     (e)          P=0.624N     P=0.483N     | 
|COCH-ARM / FISHERS |     P=0.214      (e)          (e)          P=0.500     |P=0.524N     P=0.253N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.111      (e)          (e)          (e)         |P=0.271N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     49/50 (98%)  49/50 (98%)  47/50 (94%)  49/50 (98%) |20/50 (40%)  29/49 (59%)  20/50 (40%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     49/49.08     49/49.48     47/49.22     49/49.04    |20/46.83     29/46.36     20/41.85     40/49.64     | 
|POLY-3 PERCENT (g) |     99.8%        99.0%        95.5%        99.9%       |42.7%        62.6%        47.8%        80.6%        | 
|TERMINAL (d)       |     35/35 (100%) 40/40 (100%) 34/36 (94%)  35/35 (100%)|18/40 (45%)  25/39 (64%)  15/28 (54%)  34/42 (81%)  | 
|FIRST INCIDENCE    |     572          507          392          395         |602          425          638          434          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.298      P=0.208N     P=0.393N     P=0.508     |P<0.001 **   P=0.046 *    P=0.129      P<0.001 **   | 
|POLY 3             |     P=0.603      P=0.888N     P=0.212N     P=1.000     |P<0.001 **   P=0.040 *    P=0.394      P<0.001 **   | 
|POLY 1.5           |     P=0.575      P=0.784N     P=0.216N     P=0.995     |P<0.001 **   P=0.041 *    P=0.466      P<0.001 **   | 
|POLY 6             |     P=0.656      P=0.999N     P=0.229N     P=1.000     |P<0.001 **   P=0.041 *    P=0.313      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.343      P=0.787N     P=0.374N     (e)         |P<0.001 **   P=0.038 *    P=0.300      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.618      P=0.753N     P=0.309N     P=0.753N    |P<0.001 **   P=0.044 *    P=0.581N     P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.256N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.18      1/46.35      3/45.30      2/44.60     |0/46.00      0/44.59      1/40.88      2/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         6.6%         4.5%        |0.0%         0.0%         2.5%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    1/36 (3%)    1/35 (3%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     716          605          583          491         |---          ---          702          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.372      P=0.757N     P=0.299      P=0.488     |P=0.079      (e)          P=0.444      P=0.249      | 
|POLY 3             |     P=0.380      P=0.760N     P=0.298      P=0.488     |P=0.073      (e)          P=0.476      P=0.247      | 
|POLY 1.5           |     P=0.386      P=0.760N     P=0.301      P=0.492     |P=0.070      (e)          P=0.486      P=0.243      | 
|POLY 6             |     P=0.374      P=0.759N     P=0.299      P=0.485     |P=0.075      (e)          P=0.465      P=0.252      | 
|LOGISTIC REGRESSION|     P=0.479      P=0.753      P=0.324      P=0.544     |P=0.078      (e)          P=0.483      P=0.249      | 
|COCH-ARM / FISHERS |     P=0.399      P=0.753N     P=0.309      P=0.500     |P=0.067      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.319      (e)          (e)          (e)         |P=0.080      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  30/50 (60%)  26/50 (52%)  23/50 (46%) |9/50 (18%)   10/49 (20%)  11/50 (22%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     23/46.13     30/45.93     26/44.49     23/44.06    |9/46.10      10/45.30     11/41.45     9/48.02      | 
|POLY-3 PERCENT (g) |     49.9%        65.3%        58.4%        52.2%       |19.5%        22.1%        26.5%        18.7%        | 
|TERMINAL (d)       |     23/35 (66%)  30/40 (75%)  26/36 (72%)  22/35 (63%) |8/40 (20%)   9/39 (23%)   10/28 (36%)  9/42 (21%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      689         |703          483          496          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.386N     P=0.267      P=0.369      P=0.593     |P=0.509N     P=0.476      P=0.130      P=0.557N     | 
|POLY 3             |     P=0.370N     P=0.091      P=0.267      P=0.496     |P=0.489N     P=0.483      P=0.300      P=0.565N     | 
|POLY 1.5           |     P=0.343N     P=0.102      P=0.296      P=0.524     |P=0.504N     P=0.482      P=0.339      P=0.580N     | 
|POLY 6             |     P=0.391N     P=0.082      P=0.244      P=0.475     |P=0.471N     P=0.486      P=0.251      P=0.548N     | 
|LOGISTIC REGRESSION|     P=0.452N     P=0.267      P=0.369      P=0.481     |P=0.483N     P=0.471      P=0.238      P=0.523N     | 
|COCH-ARM / FISHERS |     P=0.287N     P=0.115      P=0.345      P=0.579N    |P=0.525N     P=0.480      P=0.402      P=0.602N     | 
|ORDER RESTRICTED   |     P=0.301      (e)          (e)          (e)         |P=0.507N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.13      2/46.86      2/45.48      0/43.91     |0/46.00      0/44.59      1/41.45      1/48.18      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         4.4%         0.0%        |0.0%         0.0%         2.4%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          572          439          ---         |---          ---          496          689          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.398N     P=0.230      P=0.235      (e)         |P=0.242      (e)          P=0.496      P=0.523      | 
|POLY 3             |     P=0.401N     P=0.241      P=0.234      (e)         |P=0.245      (e)          P=0.479      P=0.509      | 
|POLY 1.5           |     P=0.394N     P=0.240      P=0.235      (e)         |P=0.238      (e)          P=0.487      P=0.506      | 
|POLY 6             |     P=0.407N     P=0.243      P=0.234      (e)         |P=0.253      (e)          P=0.469      P=0.514      | 
|LOGISTIC REGRESSION|     P=0.246N     P=0.171      P=0.255      (e)         |P=0.182      (e)          P=0.636      P=0.485      | 
|COCH-ARM / FISHERS |     P=0.381N     P=0.247      P=0.247      (e)         |P=0.227      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.274      (e)          (e)          (e)         |P=0.233      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    0/50 (0%)    3/50 (6%)   |1/50 (2%)    0/49 (0%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/46.76      4/47.41      0/44.49      3/44.01     |1/46.39      0/44.59      4/41.86      1/48.23      | 
|POLY-3 PERCENT (g) |     10.7%        8.4%         0.0%         6.8%        |2.2%         0.0%         9.6%         2.1%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    0/36 (0%)    2/35 (6%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     643          548          ---          702         |616          ---          548          675          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.370N     P=0.498N     P=0.039N*    P=0.384N    |P=0.444      P=0.504N     P=0.133      P=0.736N     | 
|POLY 3             |     P=0.353N     P=0.491N     P=0.035N*    P=0.390N    |P=0.451      P=0.508N     P=0.149      P=0.752N     | 
|POLY 1.5           |     P=0.345N     P=0.494N     P=0.033N*    P=0.378N    |P=0.437      P=0.506N     P=0.160      P=0.755N     | 
|POLY 6             |     P=0.362N     P=0.486N     P=0.037N*    P=0.403N    |P=0.468      P=0.509N     P=0.137      P=0.747N     | 
|LOGISTIC REGRESSION|     P=0.299N     P=0.514N     P=0.032N*    P=0.368N    |P=0.386      P=0.506N     P=0.226      P=0.720      | 
|COCH-ARM / FISHERS |     P=0.333N     P=0.500N     P=0.028N*    P=0.357N    |P=0.416      P=0.505N     P=0.181      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.123N     (e)          (e)          (e)         |P=0.165      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Midzonal                                                                                                      | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.13      1/45.93      2/44.59      0/43.91     |0/46.00      0/44.59      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    1/36 (3%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      703          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.350N     P=0.732N     P=0.507      P=0.500N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.350N     P=0.760      P=0.488      P=0.510N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.345N     P=0.760      P=0.492      P=0.507N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.354N     P=0.760      P=0.486      P=0.513N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.351N     P=0.732N     P=0.485      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.333N     P=0.753N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.277N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Serosa                                                                                                                    | 
|     Fibrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      2/45.93      0/44.49      0/43.91     |0/46.00      0/44.59      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.380N     P=0.268      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.375N     P=0.236      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.373N     P=0.237      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.377N     P=0.236      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.268      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.369N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.256N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    4/49 (8%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/47.05      0/45.93      1/45.33      1/44.75     |2/46.00      4/45.58      2/41.34      2/48.02      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.2%         2.2%        |4.4%         8.8%         4.8%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |2/40 (5%)    2/39 (5%)    1/28 (4%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     315          ---          392          395         |729 (T)      425          548          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.541      P=0.500N     P=0.758N     P=0.758     |P=0.422N     P=0.335      P=0.587      P=0.677N     | 
|POLY 3             |     P=0.532      P=0.505N     P=0.752      P=0.749     |P=0.416N     P=0.333      P=0.655      P=0.678N     | 
|POLY 1.5           |     P=0.536      P=0.503N     P=0.755      P=0.753     |P=0.422N     P=0.331      P=0.670      P=0.684N     | 
|POLY 6             |     P=0.529      P=0.505N     P=0.751      P=0.747     |P=0.409N     P=0.337      P=0.635      P=0.670N     | 
|LOGISTIC REGRESSION|     P=0.537N     (e)          (e)          P=0.665N    |P=0.442N     P=0.334      P=0.696N     P=0.677N     | 
|COCH-ARM / FISHERS |     P=0.545      P=0.500N     P=0.753N     P=0.753N    |P=0.428N     P=0.329      P=0.691N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.522      (e)          (e)          (e)         |P=0.479N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/49 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.26      0/45.93      1/44.98      1/44.00     |1/46.00      0/44.59      0/40.77      2/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.2%         2.3%        |2.2%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |1/40 (3%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     694          ---          583          706         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.525      P=0.505N     P=0.750      P=0.743     |P=0.247      P=0.505N     P=0.571N     P=0.517      | 
|POLY 3             |     P=0.529      P=0.501N     P=0.754      P=0.749     |P=0.238      P=0.506N     P=0.524N     P=0.515      | 
|POLY 1.5           |     P=0.533      P=0.501N     P=0.756      P=0.753     |P=0.236      P=0.505N     P=0.515N     P=0.509      | 
|POLY 6             |     P=0.524      P=0.502N     P=0.753      P=0.746     |P=0.240      P=0.506N     P=0.536N     P=0.522      | 
|LOGISTIC REGRESSION|     P=0.578      P=0.501N     P=0.745N     P=0.761     |P=0.247      (e)          (e)          P=0.517      | 
|COCH-ARM / FISHERS |     P=0.545      P=0.500N     P=0.753N     P=0.753N    |P=0.234      P=0.505N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.520      (e)          (e)          (e)         |P=0.146      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    2/50 (4%)   |6/50 (12%)   6/49 (12%)   7/50 (14%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/47.26      3/47.18      2/45.41      2/44.78     |6/48.79      6/48.07      7/44.12      1/48.35      | 
|POLY-3 PERCENT (g) |     6.4%         6.4%         4.4%         4.5%        |12.3%        12.5%        15.9%        2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     572          548          538          598         |328          425          526          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443N     P=0.644      P=0.527N     P=0.540N    |P=0.059N     P=0.598      P=0.411      P=0.056N     | 
|POLY 3             |     P=0.431N     P=0.661      P=0.518N     P=0.524N    |P=0.057N     P=0.610      P=0.423      P=0.058N     | 
|POLY 1.5           |     P=0.423N     P=0.662N     P=0.511N     P=0.516N    |P=0.056N     P=0.608      P=0.450      P=0.058N     | 
|POLY 6             |     P=0.438N     P=0.662      P=0.524N     P=0.532N    |P=0.057N     P=0.611      P=0.393      P=0.058N     | 
|LOGISTIC REGRESSION|     P=0.254N     P=0.660      P=0.429N     P=0.407N    |P=0.045N*    P=0.661N     P=0.380N     P=0.112N     | 
|COCH-ARM / FISHERS |     P=0.407N     P=0.661N     P=0.500N     P=0.500N    |P=0.054N     P=0.606      P=0.500      P=0.056N     | 
|ORDER RESTRICTED   |     P=0.539N     (e)          (e)          (e)         |P=0.044N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/46.39      1/45.93      0/44.49      0/43.91     |0/46.00      0/44.59      1/40.88      1/48.15      | 
|POLY-3 PERCENT (g) |     8.6%         2.2%         0.0%         0.0%        |0.0%         0.0%         2.5%         2.1%         | 
|TERMINAL (d)       |     2/35 (6%)    1/40 (3%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     694          729 (T)      ---          ---         |---          ---          702          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.063N     P=0.160N     P=0.065N     P=0.071N    |P=0.247      (e)          P=0.444      P=0.519      | 
|POLY 3             |     P=0.056N     P=0.182N     P=0.066N     P=0.068N    |P=0.245      (e)          P=0.476      P=0.509      | 
|POLY 1.5           |     P=0.056N     P=0.180N     P=0.064N     P=0.065N    |P=0.238      (e)          P=0.486      P=0.505      | 
|POLY 6             |     P=0.057N     P=0.183N     P=0.067N     P=0.070N    |P=0.253      (e)          P=0.465      P=0.514      | 
|LOGISTIC REGRESSION|     P=0.061N     P=0.180N     P=0.066N     P=0.068N    |P=0.228      (e)          P=0.483      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.057N     P=0.181N     P=0.059N     P=0.059N    |P=0.227      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.007N**   (e)          (e)          (e)         |P=0.229      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    3/49 (6%)    1/50 (2%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/47.06      1/46.35      1/44.70      0/43.91     |0/46.00      3/44.59      1/41.01      6/48.49      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         2.2%         0.0%        |0.0%         6.7%         2.4%         12.4%        | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    3/39 (8%)    0/28 (0%)    4/42 (10%)   | 
|FIRST INCIDENCE    |     315          608          673          ---         |---          729 (T)      665          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.207N     P=0.493N     P=0.505N     P=0.245N    |P=0.020 *    P=0.117      P=0.464      P=0.024 *    | 
|POLY 3             |     P=0.205N     P=0.505N     P=0.518N     P=0.253N    |P=0.013 *    P=0.113      P=0.477      P=0.018 *    | 
|POLY 1.5           |     P=0.202N     P=0.504N     P=0.512N     P=0.248N    |P=0.013 *    P=0.114      P=0.486      P=0.017 *    | 
|POLY 6             |     P=0.208N     P=0.504N     P=0.520N     P=0.257N    |P=0.014 *    P=0.113      P=0.466      P=0.020 *    | 
|LOGISTIC REGRESSION|     P=0.109N     P=0.590N     P=0.442N     P=0.139N    |P=0.015 *    P=0.117      P=0.517      P=0.017 *    | 
|COCH-ARM / FISHERS |     P=0.194N     P=0.500N     P=0.500N     P=0.247N    |P=0.013 *    P=0.117      P=0.500      P=0.013 *    | 
|ORDER RESTRICTED   |     P=0.131N     (e)          (e)          (e)         |P=0.004 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/49 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      0/43.91     |1/46.00      2/44.92      1/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         4.5%         2.5%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |1/40 (3%)    1/39 (3%)    1/28 (4%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      638          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.232N     P=0.494      P=0.680      P=0.490N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.224N     P=0.492      P=0.733      P=0.491N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.226N     P=0.492      P=0.744      P=0.495N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.220N     P=0.494      P=0.719      P=0.487N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.227N     P=0.494      P=0.680      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.229N     P=0.492      P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.211N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia Focal Osseous                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      2/45.93      1/44.49      2/43.91     |0/46.00      0/44.59      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.3%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    1/36 (3%)    2/35 (6%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.296      P=0.268      P=0.506      P=0.238     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.300      P=0.236      P=0.493      P=0.226     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.306      P=0.237      P=0.495      P=0.230     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.295      P=0.236      P=0.491      P=0.223     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.268      P=0.506      P=0.238     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.318      P=0.247      P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.147      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      2/43.91     |0/46.00      0/44.59      0/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    2/35 (6%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    (e)          (e)          P=0.238     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.038 *    (e)          (e)          P=0.226     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.039 *    (e)          (e)          P=0.230     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.223     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.238     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.026 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    9/50 (18%)   6/50 (12%)   5/50 (10%)  |7/50 (14%)   5/49 (10%)   3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/46.13      9/45.93      6/44.62      5/43.91     |7/46.10      5/45.33      3/40.77      3/48.15      | 
|POLY-3 PERCENT (g) |     4.3%         19.6%        13.5%        11.4%       |15.2%        11.0%        7.4%         6.2%         | 
|TERMINAL (d)       |     2/35 (6%)    9/40 (23%)   5/36 (14%)   5/35 (14%)  |6/40 (15%)   2/39 (5%)    3/28 (11%)   2/42 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      696          729 (T)     |703          598          729 (T)      696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.528      P=0.044 *    P=0.143      P=0.214     |P=0.110N     P=0.400N     P=0.337N     P=0.141N     | 
|POLY 3             |     P=0.530      P=0.024 *    P=0.122      P=0.196     |P=0.098N     P=0.391N     P=0.211N     P=0.141N     | 
|POLY 1.5           |     P=0.544      P=0.025 *    P=0.126      P=0.203     |P=0.101N     P=0.393N     P=0.189N     P=0.148N     | 
|POLY 6             |     P=0.518      P=0.024 *    P=0.120      P=0.191     |P=0.094N     P=0.383N     P=0.242N     P=0.132N     | 
|LOGISTIC REGRESSION|     P=0.516      P=0.044 *    P=0.121      P=0.214     |P=0.098N     P=0.397N     P=0.289N     P=0.132N     | 
|COCH-ARM / FISHERS |     P=0.573      P=0.026 *    P=0.134      P=0.218     |P=0.104N     P=0.394N     P=0.159N     P=0.159N     | 
|ORDER RESTRICTED   |     P=0.094      (e)          (e)          (e)         |P=0.105N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/43.13      2/45.93      0/44.49      2/43.91     |1/45.49      0/44.59      0/39.96      5/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         4.6%        |2.2%         0.0%         0.0%         10.4%        | 
|TERMINAL (d)       |     0/32 (0%)    2/40 (5%)    0/36 (0%)    2/35 (6%)   |1/40 (3%)    0/39 (0%)    0/28 (0%)    4/42 (10%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |729 (T)      ---          ---          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.282      P=0.289      (e)          P=0.258     |P=0.012 *    P=0.505N     P=0.571N     P=0.119      | 
|POLY 3             |     P=0.285      P=0.251      (e)          P=0.241     |P=0.007 **   P=0.504N     P=0.526N     P=0.115      | 
|POLY 1.5           |     P=0.289      P=0.252      (e)          P=0.244     |P=0.007 **   P=0.502N     P=0.516N     P=0.112      | 
|POLY 6             |     P=0.283      P=0.252      (e)          P=0.239     |P=0.008 **   P=0.505N     P=0.538N     P=0.119      | 
|LOGISTIC REGRESSION|     (e)          P=0.289      (e)          P=0.258     |P=0.012 *    (e)          (e)          P=0.123      | 
|COCH-ARM / FISHERS |     P=0.297      P=0.263      (e)          P=0.263     |P=0.008 **   P=0.500N     P=0.500N     P=0.107      | 
|ORDER RESTRICTED   |     P=0.119      (e)          (e)          (e)         |P=0.004 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |1/49 (2%)    0/49 (0%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.13      0/45.93      1/44.98      1/44.06     |1/46.39      0/44.59      2/41.03      2/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         2.3%        |2.2%         0.0%         4.9%         4.2%         | 
|TERMINAL (d)       |     0/32 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          583          689         |328          ---          244          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.295      (e)          P=0.487      P=0.490     |P=0.240      P=0.500N     P=0.466      P=0.511      | 
|POLY 3             |     P=0.297      (e)          P=0.508      P=0.504     |P=0.245      P=0.508N     P=0.457      P=0.512      | 
|POLY 1.5           |     P=0.301      (e)          P=0.510      P=0.507     |P=0.240      P=0.505N     P=0.474      P=0.509      | 
|POLY 6             |     P=0.295      (e)          P=0.509      P=0.503     |P=0.252      P=0.509N     P=0.437      P=0.517      | 
|LOGISTIC REGRESSION|     P=0.352      (e)          P=0.527      P=0.515     |P=0.149      (e)          P=0.742N     P=0.385      | 
|COCH-ARM / FISHERS |     P=0.310      (e)          P=0.515      P=0.515     |P=0.232      P=0.500N     P=0.500      P=0.508      | 
|ORDER RESTRICTED   |     P=0.255      (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    2/50 (4%)    1/50 (2%)    4/50 (8%)   |2/49 (4%)    1/49 (2%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.14      2/46.18      1/44.49      4/45.56     |2/45.49      1/45.30      2/40.91      2/48.02      | 
|POLY-3 PERCENT (g) |     2.3%         4.3%         2.3%         8.8%        |4.4%         2.2%         4.9%         4.2%         | 
|TERMINAL (d)       |     0/32 (0%)    1/40 (3%)    1/36 (3%)    2/35 (6%)   |2/40 (5%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     726          660          729 (T)      249         |729 (T)      483          526          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.104      P=0.538      P=0.747N     P=0.193     |P=0.521      P=0.506N     P=0.613      P=0.677N     | 
|POLY 3             |     P=0.115      P=0.524      P=0.754N     P=0.195     |P=0.533      P=0.501N     P=0.655      P=0.674N     | 
|POLY 1.5           |     P=0.116      P=0.523      P=0.751N     P=0.197     |P=0.527      P=0.501N     P=0.670      P=0.679N     | 
|POLY 6             |     P=0.113      P=0.527      P=0.755N     P=0.194     |P=0.540      P=0.501N     P=0.637      P=0.668N     | 
|LOGISTIC REGRESSION|     P=0.169      P=0.522      P=0.750N     P=0.265     |P=0.496      P=0.488N     P=0.651N     P=0.677N     | 
|COCH-ARM / FISHERS |     P=0.116      P=0.523      P=0.737N     P=0.201     |P=0.518      P=0.500N     P=0.691N     P=0.684N     | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |P=0.595      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.13      1/45.93      0/44.49      0/43.91     |0/45.49      1/45.30      0/39.96      0/48.02      | 
|POLY-3 PERCENT (g) |     4.6%         2.2%         0.0%         0.0%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/32 (6%)    1/40 (3%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          483          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.168N     P=0.422N     P=0.213N     P=0.219N    |P=0.527N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.166N     P=0.478N     P=0.230N     P=0.233N    |P=0.531N     P=0.499      (e)          (e)          | 
|POLY 1.5           |     P=0.165N     P=0.478N     P=0.228N     P=0.230N    |P=0.528N     P=0.500      (e)          (e)          | 
|POLY 6             |     P=0.167N     P=0.477N     P=0.231N     P=0.235N    |P=0.533N     P=0.499      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.168N     P=0.422N     (e)          (e)         |P=0.560N     P=0.451      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.163N     P=0.477N     P=0.232N     P=0.232N    |P=0.523N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.072N     (e)          (e)          (e)         |P=0.370N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.13      0/45.93      0/44.49      0/43.91     |2/46.39      0/44.59      0/39.96      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |1/40 (3%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |328          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.135N     P=0.243N     P=0.281N     P=0.234N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.127N     P=0.246N     P=0.272N     P=0.230N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.127N     P=0.243N     P=0.259N     P=0.231N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.128N     P=0.248N     P=0.288N     P=0.227N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.099N     P=0.218N     P=0.109N     P=0.328N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.127N     P=0.247N     P=0.247N     P=0.242N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/39 (0%)    0/49 (0%)    0/42 (0%)    0/38 (0%)   |0/32 (0%)    0/31 (0%)    0/34 (0%)    2/41 (5%)    | 
|POLY-3 RATE (b)    |     0/36.41      0/45.50      0/38.79      0/34.53     |0/29.03      0/27.22      0/29.03      2/39.35      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.1%         | 
|TERMINAL (d)       |     0/27 (0%)    0/40 (0%)    0/32 (0%)    0/27 (0%)   |0/25 (0%)    0/24 (0%)    0/21 (0%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.078      (e)          (e)          P=0.308      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.071      (e)          (e)          P=0.307      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.069      (e)          (e)          P=0.302      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.074      (e)          (e)          P=0.314      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.308      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.067      (e)          (e)          P=0.312      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.066      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/39 (3%)    0/49 (0%)    3/42 (7%)    1/38 (3%)   |5/32 (16%)   3/31 (10%)   2/34 (6%)    7/41 (17%)   | 
|POLY-3 RATE (b)    |     1/36.41      0/45.50      3/38.79      1/34.53     |5/29.03      3/27.22      2/29.03      7/39.35      | 
|POLY-3 PERCENT (g) |     2.8%         0.0%         7.7%         2.9%        |17.2%        11.0%        6.9%         17.8%        | 
|TERMINAL (d)       |     1/27 (4%)    0/40 (0%)    3/32 (9%)    1/27 (4%)   |5/25 (20%)   3/24 (13%)   2/21 (10%)   7/34 (21%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.494      P=0.422N     P=0.367      P=0.762     |P=0.424      P=0.374N     P=0.285N     P=0.606      | 
|POLY 3             |     P=0.500      P=0.455N     P=0.328      P=0.749     |P=0.426      P=0.389N     P=0.210N     P=0.601      | 
|POLY 1.5           |     P=0.505      P=0.455N     P=0.328      P=0.751     |P=0.410      P=0.382N     P=0.199N     P=0.586      | 
|POLY 6             |     P=0.493      P=0.454N     P=0.330      P=0.747     |P=0.444      P=0.393N     P=0.227N     P=0.620      | 
|LOGISTIC REGRESSION|     P=0.494      (e)          P=0.367      P=0.762     |P=0.424      P=0.374N     P=0.285N     P=0.606      | 
|COCH-ARM / FISHERS |     P=0.513      P=0.443N     P=0.336      P=0.747     |P=0.384      P=0.372N     P=0.189N     P=0.564      | 
|ORDER RESTRICTED   |     P=0.265      (e)          (e)          (e)         |P=0.365      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/39 (3%)    1/49 (2%)    5/42 (12%)   1/38 (3%)   |2/32 (6%)    3/31 (10%)   9/34 (26%)   8/41 (20%)   | 
|POLY-3 RATE (b)    |     1/36.41      1/45.50      5/39.28      1/34.53     |2/30.38      3/28.02      9/30.92      8/39.56      | 
|POLY-3 PERCENT (g) |     2.8%         2.2%         12.7%        2.9%        |6.6%         10.7%        29.1%        20.2%        | 
|TERMINAL (d)       |     1/27 (4%)    1/40 (3%)    4/32 (13%)   1/27 (4%)   |0/25 (0%)    2/24 (8%)    6/21 (29%)   7/34 (21%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      583          729 (T)     |328          425          496          675          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.589      P=0.672N     P=0.136      P=0.762     |P=0.061      P=0.489      P=0.018 *    P=0.102      | 
|POLY 3             |     P=0.588      P=0.710N     P=0.118      P=0.749     |P=0.066      P=0.463      P=0.021 *    P=0.101      | 
|POLY 1.5           |     P=0.595      P=0.710N     P=0.117      P=0.751     |P=0.062      P=0.471      P=0.024 *    P=0.098      | 
|POLY 6             |     P=0.580      P=0.709N     P=0.121      P=0.747     |P=0.072      P=0.457      P=0.018 *    P=0.105      | 
|LOGISTIC REGRESSION|     P=0.600      P=0.672N     P=0.120      P=0.762     |P=0.023 *    P=0.585      P=0.038 *    P=0.054      | 
|COCH-ARM / FISHERS |     P=0.605      P=0.693N     P=0.118      P=0.747     |P=0.059      P=0.485      P=0.028 *    P=0.096      | 
|ORDER RESTRICTED   |     P=0.236      (e)          (e)          (e)         |P=0.031 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/39 (5%)    1/49 (2%)    0/42 (0%)    4/38 (11%)  |8/32 (25%)   9/31 (29%)   7/34 (21%)   12/41 (29%)  | 
|POLY-3 RATE (b)    |     2/36.41      1/45.76      0/38.79      4/34.53     |8/29.03      9/27.93      7/29.14      12/39.38     | 
|POLY-3 PERCENT (g) |     5.5%         2.2%         0.0%         11.6%       |27.6%        32.2%        24.0%        30.5%        | 
|TERMINAL (d)       |     2/27 (7%)    0/40 (0%)    0/32 (0%)    4/27 (15%)  |8/25 (32%)   8/24 (33%)   6/21 (29%)   11/34 (32%)  | 
|FIRST INCIDENCE    |     729 (T)      660          ---          729 (T)     |729 (T)      483          701          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.069      P=0.410N     P=0.201N     P=0.334     |P=0.478      P=0.462      P=0.579      P=0.494      | 
|POLY 3             |     P=0.071      P=0.421N     P=0.222N     P=0.311     |P=0.504      P=0.462      P=0.497N     P=0.503      | 
|POLY 1.5           |     P=0.073      P=0.421N     P=0.222N     P=0.316     |P=0.479      P=0.465      P=0.472N     P=0.481      | 
|POLY 6             |     P=0.069      P=0.416N     P=0.221N     P=0.307     |P=0.534      P=0.464      P=0.532N     P=0.530      | 
|LOGISTIC REGRESSION|     P=0.070      P=0.418N     (e)          P=0.334     |P=0.548N     P=0.437      P=0.606N     P=0.544      | 
|COCH-ARM / FISHERS |     P=0.076      P=0.414N     P=0.229N     P=0.325     |P=0.440      P=0.469      P=0.446N     P=0.446      | 
|ORDER RESTRICTED   |     P=0.054      (e)          (e)          (e)         |P=0.613      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/39 (0%)    1/49 (2%)    0/42 (0%)    1/38 (3%)   |1/32 (3%)    0/31 (0%)    2/34 (6%)    0/41 (0%)    | 
|POLY-3 RATE (b)    |     0/36.41      1/45.76      0/38.79      1/34.53     |1/29.94      0/27.22      2/29.14      0/39.35      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         2.9%        |3.3%         0.0%         6.9%         0.0%         | 
|TERMINAL (d)       |     0/27 (0%)    0/40 (0%)    0/32 (0%)    1/27 (4%)   |0/25 (0%)    0/24 (0%)    1/21 (5%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          660          ---          729 (T)     |328          ---          701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.434      P=0.500      (e)          P=0.500     |P=0.452N     P=0.500N     P=0.447      P=0.500N     | 
|POLY 3             |     P=0.427      P=0.546      (e)          P=0.489     |P=0.391N     P=0.519N     P=0.491      P=0.445N     | 
|POLY 1.5           |     P=0.429      P=0.545      (e)          P=0.491     |P=0.400N     P=0.515N     P=0.503      P=0.448N     | 
|POLY 6             |     P=0.425      P=0.548      (e)          P=0.488     |P=0.381N     P=0.521N     P=0.475      P=0.441N     | 
|LOGISTIC REGRESSION|     P=0.440      P=0.589      (e)          P=0.500     |P=0.554N     (e)          P=0.515      (e)          | 
|COCH-ARM / FISHERS |     P=0.433      P=0.557      (e)          P=0.494     |P=0.413N     P=0.508N     P=0.523      P=0.438N     | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |P=0.264N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/39 (3%)    3/49 (6%)    3/42 (7%)    2/38 (5%)   |2/32 (6%)    2/31 (6%)    0/34 (0%)    11/41 (27%)  | 
|POLY-3 RATE (b)    |     1/36.41      3/45.50      3/38.93      2/34.53     |2/29.03      2/27.22      0/29.03      11/39.35     | 
|POLY-3 PERCENT (g) |     2.8%         6.6%         7.7%         5.8%        |6.9%         7.4%         0.0%         28.0%        | 
|TERMINAL (d)       |     1/27 (4%)    3/40 (8%)    2/32 (6%)    2/27 (7%)   |2/25 (8%)    2/24 (8%)    0/21 (0%)    11/34 (32%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      694          729 (T)     |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.509      P=0.454      P=0.352      P=0.500     |P=0.003 **   P=0.682      P=0.277N     P=0.029 *    | 
|POLY 3             |     P=0.514      P=0.388      P=0.329      P=0.481     |P<0.001 **   P=0.672      P=0.235N     P=0.027 *    | 
|POLY 1.5           |     P=0.520      P=0.388      P=0.329      P=0.485     |P<0.001 **   P=0.676      P=0.229N     P=0.025 *    | 
|POLY 6             |     P=0.508      P=0.391      P=0.332      P=0.479     |P<0.001 **   P=0.670      P=0.245N     P=0.030 *    | 
|LOGISTIC REGRESSION|     P=0.507      P=0.454      P=0.330      P=0.500     |P=0.003 **   P=0.682      (e)          P=0.029 *    | 
|COCH-ARM / FISHERS |     P=0.530      P=0.399      P=0.336      P=0.490     |P=0.002 **   P=0.681      P=0.231N     P=0.021 *    | 
|ORDER RESTRICTED   |     P=0.388      (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/39 (3%)    0/49 (0%)    1/42 (2%)    4/38 (11%)  |5/32 (16%)   3/31 (10%)   2/34 (6%)    9/41 (22%)   | 
|POLY-3 RATE (b)    |     1/36.70      0/45.50      1/38.79      4/36.37     |5/30.42      3/27.81      2/29.64      9/39.74      | 
|POLY-3 PERCENT (g) |     2.7%         0.0%         2.6%         11.0%       |16.4%        10.8%        6.8%         22.7%        | 
|TERMINAL (d)       |     0/27 (0%)    0/40 (0%)    1/32 (3%)    0/27 (0%)   |3/25 (12%)   2/24 (8%)    0/21 (0%)    6/34 (18%)   | 
|FIRST INCIDENCE    |     651          ---          729 (T)      491         |328          538          580          675          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.022 *    P=0.504N     P=0.750N     P=0.170     |P=0.159      P=0.381N     P=0.293N     P=0.342      | 
|POLY 3             |     P=0.015 *    P=0.457N     P=0.748N     P=0.174     |P=0.184      P=0.404N     P=0.222N     P=0.367      | 
|POLY 1.5           |     P=0.015 *    P=0.456N     P=0.747N     P=0.172     |P=0.177      P=0.394N     P=0.208N     P=0.359      | 
|POLY 6             |     P=0.015 *    P=0.457N     P=0.748N     P=0.178     |P=0.195      P=0.410N     P=0.239N     P=0.382      | 
|LOGISTIC REGRESSION|     P=0.020 *    P=0.399N     P=0.736N     P=0.381     |P=0.121      P=0.323N     P=0.146N     P=0.269      | 
|COCH-ARM / FISHERS |     P=0.015 *    P=0.443N     P=0.734N     P=0.171     |P=0.169      P=0.372N     P=0.189N     P=0.354      | 
|ORDER RESTRICTED   |     P=0.023 *    (e)          (e)          (e)         |P=0.135      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/39 (33%)  12/49 (24%)  15/42 (36%)  19/38 (50%) |16/32 (50%)  24/31 (77%)  17/34 (50%)  18/41 (44%)  | 
|POLY-3 RATE (b)    |     13/36.56     12/46.18     15/38.93     19/35.07    |16/29.46     24/29.56     17/29.53     18/39.82     | 
|POLY-3 PERCENT (g) |     35.6%        26.0%        38.5%        54.2%       |54.3%        81.2%        57.6%        45.2%        | 
|TERMINAL (d)       |     11/27 (41%)  10/40 (25%)  14/32 (44%)  18/27 (67%) |15/25 (60%)  20/24 (83%)  16/21 (76%)  16/34 (47%)  | 
|FIRST INCIDENCE    |     694          608          694          562         |605          483          580          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.167N     P=0.583N     P=0.107     |P=0.052N     P=0.023 *    P=0.208      P=0.329N     | 
|POLY 3             |     P=0.012 *    P=0.242N     P=0.488      P=0.084     |P=0.031N*    P=0.021 *    P=0.504      P=0.307N     | 
|POLY 1.5           |     P=0.014 *    P=0.248N     P=0.490      P=0.092     |P=0.042N*    P=0.020 *    P=0.553      P=0.337N     | 
|POLY 6             |     P=0.010 *    P=0.226N     P=0.497      P=0.076     |P=0.020N*    P=0.023 *    P=0.427      P=0.270N     | 
|LOGISTIC REGRESSION|     P=0.010 *    P=0.248N     P=0.536      P=0.073     |P=0.032N*    P=0.015 *    P=0.398      P=0.283N     | 
|COCH-ARM / FISHERS |     P=0.018 *    P=0.249N     P=0.504      P=0.105     |P=0.071N     P=0.022 *    P=0.597N     P=0.389N     | 
|ORDER RESTRICTED   |     P=0.028 *    (e)          (e)          (e)         |P=0.031N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/39 (3%)    0/49 (0%)    0/42 (0%)    1/38 (3%)   |4/32 (13%)   2/31 (6%)    0/34 (0%)    1/41 (2%)    | 
|POLY-3 RATE (b)    |     1/36.41      0/45.50      0/38.79      1/35.22     |4/30.84      2/28.14      0/29.03      1/39.38      | 
|POLY-3 PERCENT (g) |     2.8%         0.0%         0.0%         2.8%        |13.0%        7.1%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/27 (4%)    0/40 (0%)    0/32 (0%)    0/27 (0%)   |1/25 (4%)    0/24 (0%)    0/21 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          491         |328          538          ---          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.513      P=0.422N     P=0.466N     P=0.758     |P=0.085N     P=0.359N     P=0.085N     P=0.157N     | 
|POLY 3             |     P=0.508      P=0.455N     P=0.487N     P=0.753     |P=0.051N     P=0.379N     P=0.065N     P=0.110N     | 
|POLY 1.5           |     P=0.508      P=0.455N     P=0.487N     P=0.754     |P=0.052N     P=0.369N     P=0.058N     P=0.110N     | 
|POLY 6             |     P=0.506      P=0.454N     P=0.486N     P=0.753     |P=0.051N     P=0.384N     P=0.074N     P=0.109N     | 
|LOGISTIC REGRESSION|     P=0.557      (e)          (e)          P=0.631N    |P=0.089N     P=0.220N     P=0.026N*    P=0.185N     | 
|COCH-ARM / FISHERS |     P=0.508      P=0.443N     P=0.481N     P=0.747     |P=0.055N     P=0.351N     P=0.050N     P=0.112N     | 
|ORDER RESTRICTED   |     P=0.373      (e)          (e)          (e)         |P=0.019N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/48 (15%)   1/47 (2%)    3/45 (7%)    2/42 (5%)   |33/50 (66%)  35/50 (70%)  22/50 (44%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     7/45.50      1/44.02      3/41.06      2/36.97     |33/46.32     35/45.74     22/41.65     19/48.36     | 
|POLY-3 PERCENT (g) |     15.4%        2.3%         7.3%         5.4%        |71.2%        76.5%        52.8%        39.3%        | 
|TERMINAL (d)       |     3/34 (9%)    1/39 (3%)    2/34 (6%)    2/30 (7%)   |31/40 (78%)  32/39 (82%)  17/28 (61%)  17/42 (41%)  | 
|FIRST INCIDENCE    |     689          729 (T)      694          729 (T)     |671          598          665          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.243N     P=0.029N*    P=0.173N     P=0.114N    |P<0.001N**   P=0.332      P=0.441N     P=0.002N**   | 
|POLY 3             |     P=0.253N     P=0.033N*    P=0.202N     P=0.138N    |P<0.001N**   P=0.361      P=0.050N     P<0.001N**   | 
|POLY 1.5           |     P=0.247N     P=0.033N*    P=0.196N     P=0.131N    |P<0.001N**   P=0.381      P=0.035N*    P=0.002N**   | 
|POLY 6             |     P=0.260N     P=0.033N*    P=0.205N     P=0.144N    |P<0.001N**   P=0.357      P=0.076N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.259N     P=0.035N*    P=0.196N     P=0.135N    |P<0.001N**   P=0.322      P=0.177N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.232N     P=0.032N*    P=0.186N     P=0.115N    |P<0.001N**   P=0.415      P=0.022N*    P=0.004N**   | 
|ORDER RESTRICTED   |     P=0.058N     (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    1/45 (2%)    0/42 (0%)   |2/50 (4%)    3/50 (6%)    7/50 (14%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.05      0/44.02      1/41.50      0/36.97     |2/46.54      3/46.72      7/44.02      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         0.0%        |4.3%         6.4%         15.9%        0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/39 (0%)    0/34 (0%)    0/30 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          548          ---         |653          425          496          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.789N     (e)          P=0.487      (e)         |P=0.265N     P=0.492      P=0.061      P=0.223N     | 
|POLY 3             |     P=0.794      (e)          P=0.484      (e)         |P=0.250N     P=0.502      P=0.066      P=0.230N     | 
|POLY 1.5           |     P=0.799      (e)          P=0.484      (e)         |P=0.259N     P=0.502      P=0.070      P=0.233N     | 
|POLY 6             |     P=0.791      (e)          P=0.485      (e)         |P=0.241N     P=0.502      P=0.061      P=0.228N     | 
|LOGISTIC REGRESSION|     P=0.656N     (e)          P=0.790      (e)         |P=0.326N     P=0.563      P=0.164      P=0.274N     | 
|COCH-ARM / FISHERS |     P=0.805N     (e)          P=0.484      (e)         |P=0.277N     P=0.500      P=0.080      P=0.247N     | 
|ORDER RESTRICTED   |     P=0.370      (e)          (e)          (e)         |P=0.054N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    0/47 (0%)    0/45 (0%)    0/42 (0%)   |3/50 (6%)    5/50 (10%)   4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/45.05      0/44.02      0/40.93      0/36.97     |3/46.87      5/45.18      4/41.34      3/48.02      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |6.4%         11.1%        9.7%         6.3%         | 
|TERMINAL (d)       |     2/34 (6%)    0/39 (0%)    0/34 (0%)    0/30 (0%)   |1/40 (3%)    4/39 (10%)   3/28 (11%)   3/42 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |588          680          548          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268N     P=0.209N     P=0.238N     P=0.266N    |P=0.449N     P=0.347      P=0.364      P=0.637N     | 
|POLY 3             |     P=0.261N     P=0.242N     P=0.259N     P=0.283N    |P=0.451N     P=0.337      P=0.432      P=0.651N     | 
|POLY 1.5           |     P=0.260N     P=0.243N     P=0.257N     P=0.279N    |P=0.457N     P=0.345      P=0.459      P=0.655N     | 
|POLY 6             |     P=0.262N     P=0.240N     P=0.259N     P=0.284N    |P=0.445N     P=0.329      P=0.398      P=0.646N     | 
|LOGISTIC REGRESSION|     P=0.268N     (e)          (e)          (e)         |P=0.464N     P=0.362      P=0.544      P=0.626      | 
|COCH-ARM / FISHERS |     P=0.261N     P=0.253N     P=0.264N     P=0.282N    |P=0.465N     P=0.357      P=0.500      P=0.661N     | 
|ORDER RESTRICTED   |     P=0.049N*    (e)          (e)          (e)         |P=0.489N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/45 (0%)    1/42 (2%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.05      0/44.02      0/40.93      1/37.12     |1/46.43      0/44.99      2/41.64      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.7%        |2.2%         0.0%         4.8%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/39 (0%)    0/34 (0%)    0/30 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          689         |602          ---          598          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      (e)          (e)          P=0.485     |P=0.471N     P=0.513N     P=0.450      P=0.492N     | 
|POLY 3             |     P=0.187      (e)          (e)          P=0.461     |P=0.466N     P=0.506N     P=0.462      P=0.493N     | 
|POLY 1.5           |     P=0.189      (e)          (e)          P=0.464     |P=0.473N     P=0.504N     P=0.477      P=0.496N     | 
|POLY 6             |     P=0.186      (e)          (e)          P=0.461     |P=0.458N     P=0.508N     P=0.445      P=0.490N     | 
|LOGISTIC REGRESSION|     P=0.201      (e)          (e)          P=0.484     |P=0.517N     P=0.497N     P=0.612      P=0.577N     | 
|COCH-ARM / FISHERS |     P=0.195      (e)          (e)          P=0.467     |P=0.485N     P=0.500N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.093      (e)          (e)          (e)         |P=0.301N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/26 (0%)    0/46 (0%)    0/35 (0%)    2/20 (10%)  |0/8 (0%)     0/10 (0%)    0/12 (0%)    0/9 (0%)     | 
|POLY-3 RATE (b)    |     0/23.45      0/43.82      0/32.63      2/18.53     |0/7.19       0/9.03       0/9.00       0/8.21       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         10.8%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/15 (0%)    0/40 (0%)    0/27 (0%)    1/13 (8%)   |0/5 (0%)     0/7 (0%)     0/4 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          249         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.019 *    (e)          (e)          P=0.226     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.008 **   (e)          (e)          P=0.181     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.008 **   (e)          (e)          P=0.179     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.007 **   (e)          (e)          P=0.185     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.060      (e)          (e)          P=0.365     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.009 **   (e)          (e)          P=0.184     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.015 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/26 (4%)    1/46 (2%)    2/35 (6%)    0/20 (0%)   |0/8 (0%)     1/10 (10%)   2/12 (17%)   0/9 (0%)     | 
|POLY-3 RATE (b)    |     1/23.74      1/44.46      2/33.96      0/17.57     |0/7.19       1/9.36       2/10.07      0/8.21       | 
|POLY-3 PERCENT (g) |     4.2%         2.3%         5.9%         0.0%        |0.0%         10.7%        19.9%        0.0%         | 
|TERMINAL (d)       |     0/15 (0%)    0/40 (0%)    0/27 (0%)    0/13 (0%)   |0/5 (0%)     0/7 (0%)     0/4 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     651          521          392          ---         |---          638          548          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.350N     P=0.756      P=0.482      P=0.519N    |P=0.593N     P=0.495      P=0.214      (e)          | 
|POLY 3             |     P=0.497N     P=0.614N     P=0.623      P=0.560N    |P=0.592N     P=0.552      P=0.305      (e)          | 
|POLY 1.5           |     P=0.491N     P=0.621N     P=0.614      P=0.559N    |P=0.597N     P=0.549      P=0.314      (e)          | 
|POLY 6             |     P=0.504N     P=0.603N     P=0.636      P=0.559N    |P=0.575N     P=0.558      P=0.293      (e)          | 
|LOGISTIC REGRESSION|     P=0.111N     P=0.639N     P=0.671      P=0.521N    |P=0.394N     P=0.521      P=0.729      (e)          | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.595N     P=0.612      P=0.565N    |P=0.594N     P=0.556      P=0.347      (e)          | 
|ORDER RESTRICTED   |     P=0.433N     (e)          (e)          (e)         |P=0.368N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/26 (31%)   10/46 (22%)  16/35 (46%)  10/20 (50%) |5/8 (63%)    7/10 (70%)   6/12 (50%)   3/9 (33%)    | 
|POLY-3 RATE (b)    |     8/23.90      10/43.82     16/33.31     10/17.88    |5/7.19       7/9.03       6/9.46       3/8.21       | 
|POLY-3 PERCENT (g) |     33.5%        22.8%        48.0%        55.9%       |69.6%        77.5%        63.4%        36.5%        | 
|TERMINAL (d)       |     5/15 (33%)   10/40 (25%)  12/27 (44%)  8/13 (62%)  |5/5 (100%)   7/7 (100%)   3/4 (75%)    3/8 (38%)    | 
|FIRST INCIDENCE    |     668          729 (T)      668          689         |729 (T)      729 (T)      665          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.041 *    P=0.134N     P=0.290      P=0.276     |P=0.023N*    P=1.000N     P=0.261      P=0.055N     | 
|POLY 3             |     P=0.015 *    P=0.256N     P=0.203      P=0.124     |P=0.058N     P=0.587      P=0.610N     P=0.213N     | 
|POLY 1.5           |     P=0.017 *    P=0.270N     P=0.188      P=0.128     |P=0.077N     P=0.575      P=0.541N     P=0.232N     | 
|POLY 6             |     P=0.013 *    P=0.232N     P=0.236      P=0.126     |P=0.028N*    P=0.612      P=0.711N     P=0.173N     | 
|LOGISTIC REGRESSION|     P=0.015 *    P=0.186N     P=0.216      P=0.140     |P=0.020N*    P=1.000N     P=0.471      P=0.055N     | 
|COCH-ARM / FISHERS |     P=0.027 *    P=0.283N     P=0.180      P=0.154     |P=0.088N     P=0.563      P=0.465N     P=0.238N     | 
|ORDER RESTRICTED   |     P=0.076      (e)          (e)          (e)         |P=0.097N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/49 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.18      0/45.93      1/44.49      0/43.91     |1/46.00      1/44.59      0/40.77      2/48.05      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         2.3%         0.0%        |2.2%         2.2%         0.0%         4.2%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    1/36 (3%)    0/35 (0%)   |1/40 (3%)    1/39 (3%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     716          ---          729 (T)      ---         |729 (T)      729 (T)      ---          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.286N     P=0.220N     P=0.497N     P=0.249N    |P=0.385      P=0.756      P=0.571N     P=0.522      | 
|POLY 3             |     P=0.279N     P=0.238N     P=0.513N     P=0.249N    |P=0.378      P=0.754      P=0.524N     P=0.515      | 
|POLY 1.5           |     P=0.277N     P=0.238N     P=0.508N     P=0.245N    |P=0.375      P=0.754      P=0.515N     P=0.509      | 
|POLY 6             |     P=0.281N     P=0.238N     P=0.516N     P=0.252N    |P=0.382      P=0.754      P=0.536N     P=0.523      | 
|LOGISTIC REGRESSION|     P=0.285N     P=0.237N     P=0.513N     P=0.251N    |P=0.394      P=0.756      (e)          P=0.530      | 
|COCH-ARM / FISHERS |     P=0.271N     P=0.247N     P=0.500N     P=0.247N    |P=0.371      P=0.747      P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.081N     (e)          (e)          (e)         |P=0.299      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   1/50 (2%)    2/50 (4%)   |4/50 (8%)    2/49 (4%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.13      5/46.80      1/44.49      2/43.91     |4/46.00      2/44.59      4/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         10.7%        2.3%         4.6%        |8.7%         4.5%         9.8%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    3/40 (8%)    1/36 (3%)    2/35 (6%)   |4/40 (10%)   2/39 (5%)    4/28 (14%)   0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          507          729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.609      P=0.043 *    P=0.506      P=0.238     |P=0.089N     P=0.348N     P=0.438      P=0.057N     | 
|POLY 3             |     P=0.612      P=0.032 *    P=0.493      P=0.226     |P=0.072N     P=0.352N     P=0.576      P=0.055N     | 
|POLY 1.5           |     P=0.620      P=0.032 *    P=0.495      P=0.230     |P=0.076N     P=0.350N     P=0.602      P=0.057N     | 
|POLY 6             |     P=0.606      P=0.032 *    P=0.491      P=0.223     |P=0.067N     P=0.351N     P=0.541      P=0.053N     | 
|LOGISTIC REGRESSION|     P=0.606N     P=0.030 *    P=0.506      P=0.238     |P=0.089N     P=0.348N     P=0.438      (e)          | 
|COCH-ARM / FISHERS |     P=0.609N     P=0.028 *    P=0.500      P=0.247     |P=0.083N     P=0.349N     P=0.643N     P=0.059N     | 
|ORDER RESTRICTED   |     P=0.131      (e)          (e)          (e)         |P=0.041N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   5/49 (10%)   2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |5/47.78      5/45.30      2/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |                                                        |10.5%        11.0%        4.9%         0.0%         | 
|TERMINAL (d)       |                                                        |2/40 (5%)    4/39 (10%)   2/28 (7%)    0/42 (0%)    | 
|FIRST INCIDENCE    |                                                        |328          483          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.015N*    P=0.612      P=0.331N     P=0.033N*    | 
|POLY 3             |                                                        |P=0.012N*    P=0.596      P=0.286N     P=0.030N*    | 
|POLY 1.5           |                                                        |P=0.012N*    P=0.603      P=0.258N     P=0.031N*    | 
|POLY 6             |                                                        |P=0.011N*    P=0.591      P=0.321N     P=0.030N*    | 
|LOGISTIC REGRESSION|                                                        |P=0.011N*    P=0.615N     P=0.135N     P=0.046N*    | 
|COCH-ARM / FISHERS |                                                        |P=0.012N*    P=0.617      P=0.218N     P=0.028N*    | 
|ORDER RESTRICTED   |                                                        |P=0.019N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Periovarian Tissue                                                                                                        | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   5/49 (10%)   4/50 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |5/46.42      5/45.04      4/41.56      6/48.15      | 
|POLY-3 PERCENT (g) |                                                        |10.8%        11.1%        9.6%         12.5%        | 
|TERMINAL (d)       |                                                        |4/40 (10%)   4/39 (10%)   2/28 (7%)    5/42 (12%)   | 
|FIRST INCIDENCE    |                                                        |605          598          496          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.461      P=0.610      P=0.599      P=0.537      | 
|POLY 3             |                                                        |P=0.463      P=0.611      P=0.569N     P=0.525      | 
|POLY 1.5           |                                                        |P=0.455      P=0.613      P=0.542N     P=0.516      | 
|POLY 6             |                                                        |P=0.474      P=0.612      P=0.603N     P=0.538      | 
|LOGISTIC REGRESSION|                                                        |P=0.450      P=0.617      P=0.503N     P=0.514      | 
|COCH-ARM / FISHERS |                                                        |P=0.443      P=0.617      P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.593      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/49 (45%)  27/49 (55%)  20/50 (40%)  36/50 (72%) |13/50 (26%)  14/49 (29%)  13/49 (27%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     22/46.91     27/45.98     20/45.66     36/47.35    |13/47.38     14/44.59     13/42.12     11/48.36     | 
|POLY-3 PERCENT (g) |     46.9%        58.7%        43.8%        76.0%       |27.4%        31.4%        30.9%        22.8%        | 
|TERMINAL (d)       |     13/35 (37%)  24/40 (60%)  16/36 (44%)  26/35 (74%) |11/40 (28%)  14/39 (36%)  8/28 (29%)   9/42 (21%)   | 
|FIRST INCIDENCE    |     603          660          538          395         |328          729 (T)      526          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.386      P=0.417N     P=0.012 *   |P=0.296N     P=0.468      P=0.264      P=0.359N     | 
|POLY 3             |     P=0.003 **   P=0.173      P=0.464N     P=0.002 **  |P=0.278N     P=0.426      P=0.451      P=0.385N     | 
|POLY 1.5           |     P=0.003 **   P=0.191      P=0.431N     P=0.003 **  |P=0.294N     P=0.442      P=0.491      P=0.397N     | 
|POLY 6             |     P=0.002 **   P=0.153      P=0.500N     P=0.002 **  |P=0.254N     P=0.415      P=0.409      P=0.365N     | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.209      P=0.425N     P=0.004 **  |P=0.291N     P=0.469      P=0.564      P=0.439N     | 
|COCH-ARM / FISHERS |     P=0.005 **   P=0.210      P=0.386N     P=0.005 **  |P=0.309N     P=0.475      P=0.567      P=0.408N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.340N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst Focal                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/49 (12%)   3/49 (6%)    5/50 (10%)   12/50 (24%) |10/50 (20%)  12/49 (24%)  4/49 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     6/45.56      3/45.49      5/44.49      12/44.46    |10/46.00     12/45.04     4/40.34      6/48.02      | 
|POLY-3 PERCENT (g) |     13.2%        6.6%         11.2%        27.0%       |21.7%        26.6%        9.9%         12.5%        | 
|TERMINAL (d)       |     4/35 (11%)   2/40 (5%)    5/36 (14%)   10/35 (29%) |10/40 (25%)  11/39 (28%)  4/28 (14%)   6/42 (14%)   | 
|FIRST INCIDENCE    |     651          693          729 (T)      598         |729 (T)      598          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.007 **   P=0.208N     P=0.490N     P=0.095     |P=0.063N     P=0.376      P=0.222N     P=0.174N     | 
|POLY 3             |     P=0.008 **   P=0.243N     P=0.517N     P=0.083     |P=0.055N     P=0.382      P=0.115N     P=0.179N     | 
|POLY 1.5           |     P=0.008 **   P=0.242N     P=0.505N     P=0.089     |P=0.058N     P=0.382      P=0.100N     P=0.190N     | 
|POLY 6             |     P=0.007 **   P=0.242N     P=0.527N     P=0.077     |P=0.051N     P=0.388      P=0.137N     P=0.166N     | 
|LOGISTIC REGRESSION|     P=0.007 **   P=0.240N     P=0.514N     P=0.084     |P=0.051N     P=0.373      P=0.222N     P=0.174N     | 
|COCH-ARM / FISHERS |     P=0.011 *    P=0.243N     P=0.486N     P=0.104     |P=0.064N     P=0.384      P=0.080N     P=0.207N     | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |P=0.068N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Hyperplasia Cystic Focal                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/49 (4%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.14      2/45.35      3/44.49      0/43.91     |0/46.00      0/44.59      0/40.34      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         6.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    3/36 (8%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.401N     P=0.268      P=0.126      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.399N     P=0.238      P=0.116      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.391N     P=0.238      P=0.118      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.405N     P=0.239      P=0.114      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.268      P=0.126      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.375N     P=0.247      P=0.125      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.223      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    0/49 (0%)    1/48 (2%)    0/49 (0%)   |0/49 (0%)    0/48 (0%)    0/49 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     2/43.42      0/44.93      1/42.72      0/42.91     |0/45.00      0/43.70      0/40.10      0/45.81      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/33 (3%)    0/39 (0%)    1/35 (3%)    0/34 (0%)   |0/39 (0%)    0/39 (0%)    0/28 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     694          ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.283N     P=0.224N     P=0.489N     P=0.248N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.273N     P=0.229N     P=0.506N     P=0.240N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.271N     P=0.228N     P=0.501N     P=0.236N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.276N     P=0.230N     P=0.509N     P=0.244N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.277N     P=0.229N     P=0.505N     P=0.237N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.266N     P=0.237N     P=0.492N     P=0.237N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.076N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |5/50 (10%)   9/48 (19%)   7/50 (14%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.41      0/45.93      3/44.63      0/43.91     |5/46.00      9/44.69      7/42.17      2/48.02      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         6.7%         0.0%        |10.9%        20.1%        16.6%        4.2%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    2/36 (6%)    0/35 (0%)   |5/40 (13%)   7/39 (18%)   3/28 (11%)   2/42 (5%)    | 
|FIRST INCIDENCE    |     651          ---          694          ---         |729 (T)      425          548          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.319N     P=0.227N     P=0.499      P=0.250N    |P=0.099N     P=0.184      P=0.201      P=0.197N     | 
|POLY 3             |     P=0.315N     P=0.240N     P=0.482      P=0.250N    |P=0.075N     P=0.176      P=0.319      P=0.199N     | 
|POLY 1.5           |     P=0.309N     P=0.238N     P=0.489      P=0.245N    |P=0.081N     P=0.174      P=0.341      P=0.206N     | 
|POLY 6             |     P=0.321N     P=0.240N     P=0.478      P=0.254N    |P=0.068N     P=0.180      P=0.294      P=0.191N     | 
|LOGISTIC REGRESSION|     P=0.304N     P=0.239N     P=0.492      P=0.233N    |P=0.090N     P=0.170      P=0.345      P=0.197N     | 
|COCH-ARM / FISHERS |     P=0.297N     P=0.247N     P=0.500      P=0.247N    |P=0.091N     P=0.172      P=0.380      P=0.218N     | 
|ORDER RESTRICTED   |     P=0.162N     (e)          (e)          (e)         |P=0.059N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/48 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.14      2/45.93      2/44.49      1/44.07     |0/46.00      0/43.78      0/40.77      1/48.02      | 
|POLY-3 PERCENT (g) |     6.5%         4.4%         4.5%         2.3%        |0.0%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     2/35 (6%)    2/40 (5%)    2/36 (6%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     726          729 (T)      729 (T)      687         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.289N     P=0.442N     P=0.490N     P=0.313N    |P=0.208      (e)          (e)          P=0.510      | 
|POLY 3             |     P=0.284N     P=0.502N     P=0.517N     P=0.322N    |P=0.203      (e)          (e)          P=0.509      | 
|POLY 1.5           |     P=0.280N     P=0.501N     P=0.510N     P=0.317N    |P=0.201      (e)          (e)          P=0.505      | 
|POLY 6             |     P=0.288N     P=0.502N     P=0.520N     P=0.325N    |P=0.206      (e)          (e)          P=0.513      | 
|LOGISTIC REGRESSION|     P=0.292N     P=0.469N     P=0.505N     P=0.325N    |(e)          (e)          (e)          P=0.510      | 
|COCH-ARM / FISHERS |     P=0.269N     P=0.500N     P=0.500N     P=0.309N    |P=0.196      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.263N     (e)          (e)          (e)         |P=0.129      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    2/50 (4%)    3/50 (6%)   |1/50 (2%)    5/48 (10%)   2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.13      4/45.93      2/44.49      3/43.91     |1/46.00      5/43.78      2/41.10      1/48.15      | 
|POLY-3 PERCENT (g) |     2.2%         8.7%         4.5%         6.8%        |2.2%         11.4%        4.9%         2.1%         | 
|TERMINAL (d)       |     1/35 (3%)    4/40 (10%)   2/36 (6%)    3/35 (9%)   |1/40 (3%)    5/39 (13%)   1/28 (4%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      638          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.419      P=0.221      P=0.510      P=0.305     |P=0.296N     P=0.097      P=0.404      P=0.745N     | 
|POLY 3             |     P=0.424      P=0.177      P=0.487      P=0.288     |P=0.279N     P=0.090      P=0.461      P=0.750N     | 
|POLY 1.5           |     P=0.433      P=0.179      P=0.492      P=0.294     |P=0.286N     P=0.091      P=0.476      P=0.754N     | 
|POLY 6             |     P=0.416      P=0.177      P=0.485      P=0.283     |P=0.270N     P=0.090      P=0.442      P=0.745N     | 
|LOGISTIC REGRESSION|     P=0.419      P=0.221      P=0.510      P=0.305     |P=0.285N     P=0.097      P=0.476      P=0.762N     | 
|COCH-ARM / FISHERS |     P=0.450      P=0.181      P=0.500      P=0.309     |P=0.295N     P=0.093      P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.267      (e)          (e)          (e)         |P=0.231N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    2/50 (4%)    5/50 (10%)  |4/50 (8%)    4/48 (8%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/46.13      4/47.79      2/44.49      5/44.36     |4/46.47      4/43.78      1/40.77      3/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         8.4%         4.5%         11.3%       |8.6%         9.1%         2.5%         6.3%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    2/36 (6%)    4/35 (11%)  |3/40 (8%)    4/39 (10%)   1/28 (4%)    3/42 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      507          729 (T)      598         |588          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.122      P=0.189      P=0.510      P=0.102     |P=0.328N     P=0.626      P=0.287N     P=0.476N     | 
|POLY 3             |     P=0.122      P=0.190      P=0.487      P=0.092     |P=0.323N     P=0.610      P=0.221N     P=0.482N     | 
|POLY 1.5           |     P=0.127      P=0.186      P=0.492      P=0.095     |P=0.324N     P=0.614      P=0.204N     P=0.489N     | 
|POLY 6             |     P=0.118      P=0.196      P=0.485      P=0.090     |P=0.320N     P=0.609      P=0.244N     P=0.474N     | 
|LOGISTIC REGRESSION|     P=0.165      P=0.138      P=0.510      P=0.096     |P=0.309N     P=0.618      P=0.199N     P=0.503N     | 
|COCH-ARM / FISHERS |     P=0.137      P=0.181      P=0.500      P=0.102     |P=0.325N     P=0.619      P=0.181N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.060      (e)          (e)          (e)         |P=0.305N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |9/50 (18%)   14/48 (29%)  8/50 (16%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     1/46.13      1/46.50      1/44.49      1/43.91     |9/46.87      14/44.49     8/42.00      5/48.15      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         2.3%         2.3%        |19.2%        31.5%        19.1%        10.4%        | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    1/36 (3%)    1/35 (3%)   |7/40 (18%)   13/39 (33%)  6/28 (21%)   4/42 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      548          729 (T)      729 (T)     |588          483          332          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.653      P=0.748N     P=0.756N     P=0.762     |P=0.058N     P=0.156      P=0.447      P=0.172N     | 
|POLY 3             |     P=0.648      P=0.759N     P=0.753      P=0.750     |P=0.044N*    P=0.133      P=0.599N     P=0.178N     | 
|POLY 1.5           |     P=0.654      P=0.759N     P=0.755      P=0.753     |P=0.046N*    P=0.137      P=0.558N     P=0.184N     | 
|POLY 6             |     P=0.642      P=0.757N     P=0.751      P=0.747     |P=0.041N*    P=0.129      P=0.560      P=0.171N     | 
|LOGISTIC REGRESSION|     P=0.655N     P=0.745      P=0.756N     P=0.762     |P=0.051N     P=0.141      P=0.500N     P=0.195N     | 
|COCH-ARM / FISHERS |     P=0.667      P=0.753N     P=0.753N     P=0.753N    |P=0.052N     P=0.143      P=0.500N     P=0.194N     | 
|ORDER RESTRICTED   |     P=0.731      (e)          (e)          (e)         |P=0.043N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/48 (6%)    4/50 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      0/43.91     |1/46.00      3/43.78      4/42.06      6/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         6.9%         9.5%         12.5%        | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |1/40 (3%)    3/39 (8%)    1/28 (4%)    6/42 (14%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      532          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.050      P=0.296      P=0.123      P=0.066      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.047 *    P=0.288      P=0.152      P=0.063      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044 *    P=0.289      P=0.162      P=0.061      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.050      P=0.289      P=0.141      P=0.067      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.042 *    P=0.296      P=0.220      P=0.066      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.041 *    P=0.293      P=0.181      P=0.056      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.038 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    1/48 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.41      1/45.93      0/44.49      2/44.45     |1/46.00      1/43.78      1/40.77      1/48.05      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         0.0%         4.5%        |2.2%         2.3%         2.5%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/36 (0%)    1/35 (3%)   |1/40 (3%)    1/39 (3%)    1/28 (4%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     668          729 (T)      ---          562         |729 (T)      729 (T)      729 (T)      722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.490      P=0.481N     P=0.248N     P=0.674     |P=0.615N     P=0.756      P=0.680      P=0.744N     | 
|POLY 3             |     P=0.502      P=0.504N     P=0.247N     P=0.678     |P=0.619N     P=0.750      P=0.733      P=0.751N     | 
|POLY 1.5           |     P=0.504      P=0.502N     P=0.243N     P=0.683     |P=0.622N     P=0.750      P=0.744      P=0.755N     | 
|POLY 6             |     P=0.499      P=0.505N     P=0.250N     P=0.674     |P=0.616N     P=0.750      P=0.719      P=0.746N     | 
|LOGISTIC REGRESSION|     P=0.531      P=0.500N     P=0.234N     P=0.673N    |P=0.606N     P=0.756      P=0.680      P=0.745N     | 
|COCH-ARM / FISHERS |     P=0.512      P=0.500N     P=0.247N     P=0.691N    |P=0.626N     P=0.742      P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.399      (e)          (e)          (e)         |P=0.714N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/48 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/46.13      2/46.18      0/44.49      1/43.91     |0/46.00      0/43.78      1/41.39      3/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         2.3%        |0.0%         0.0%         2.4%         6.3%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/36 (0%)    1/35 (3%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    3/42 (7%)    | 
|FIRST INCIDENCE    |     ---          660          ---          729 (T)     |---          ---          526          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.606      P=0.254      (e)          P=0.500     |P=0.024 *    (e)          P=0.492      P=0.130      | 
|POLY 3             |     P=0.609      P=0.237      (e)          P=0.490     |P=0.021 *    (e)          P=0.479      P=0.127      | 
|POLY 1.5           |     P=0.613      P=0.238      (e)          P=0.493     |P=0.020 *    (e)          P=0.487      P=0.124      | 
|POLY 6             |     P=0.605      P=0.238      (e)          P=0.487     |P=0.022 *    (e)          P=0.469      P=0.131      | 
|LOGISTIC REGRESSION|     P=0.616      P=0.237      (e)          P=0.500     |P=0.017 *    (e)          P=0.615      P=0.130      | 
|COCH-ARM / FISHERS |     P=0.622      P=0.247      (e)          P=0.500     |P=0.020 *    (e)          P=0.500      P=0.121      | 
|ORDER RESTRICTED   |     P=0.316      (e)          (e)          (e)         |P=0.024 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Rathke's Cleft                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      0/43.91     |0/46.00      0/43.78      0/40.77      2/48.23      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          675          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.057      (e)          (e)          P=0.260      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.248      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.244      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.048 *    (e)          (e)          P=0.254      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.229      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.033 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      2/44.34     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    1/35 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          605         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    (e)          (e)          P=0.230     |                                                    | 
|POLY 3             |     P=0.039 *    (e)          (e)          P=0.228     |                                                    | 
|POLY 1.5           |     P=0.039 *    (e)          (e)          P=0.231     |                                                    | 
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.227     |                                                    | 
|LOGISTIC REGRESSION|     P=0.047 *    (e)          (e)          P=0.251     |                                                    | 
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.026 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.13      0/45.93      2/44.59      1/44.07     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         4.5%         2.3%        |                                                    | 
|TERMINAL (d)       |     2/35 (6%)    0/40 (0%)    1/36 (3%)    0/35 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      ---          703          687         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.614N     P=0.209N     P=0.686N     P=0.503N    |                                                    | 
|POLY 3             |     P=0.610N     P=0.238N     P=0.682      P=0.516N    |                                                    | 
|POLY 1.5           |     P=0.606N     P=0.238N     P=0.686      P=0.511N    |                                                    | 
|POLY 6             |     P=0.613N     P=0.238N     P=0.680      P=0.519N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.614N     (e)          P=0.681      P=0.518N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.596N     P=0.247N     P=0.691N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.430N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.13      1/45.93      1/44.63      2/44.23     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.2%         4.5%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/36 (0%)    0/35 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      694          687         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183      P=0.527      P=0.495      P=0.232     |                                                    | 
|POLY 3             |     P=0.184      P=0.499      P=0.493      P=0.228     |                                                    | 
|POLY 1.5           |     P=0.187      P=0.500      P=0.496      P=0.231     |                                                    | 
|POLY 6             |     P=0.182      P=0.499      P=0.492      P=0.226     |                                                    | 
|LOGISTIC REGRESSION|     P=0.191      P=0.527      P=0.502      P=0.240     |                                                    | 
|COCH-ARM / FISHERS |     P=0.194      P=0.500      P=0.500      P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.111      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    10/50 (20%)  10/50 (20%)  11/50 (22%) |                                                    | 
|POLY-3 RATE (b)    |     4/46.96      10/46.77     10/44.49     11/46.33    |                                                    | 
|POLY-3 PERCENT (g) |     8.5%         21.4%        22.5%        23.7%       |                                                    | 
|TERMINAL (d)       |     2/35 (6%)    8/40 (20%)   10/36 (28%)  5/35 (14%)  |                                                    | 
|FIRST INCIDENCE    |     572          605          729 (T)      491         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.098      P=0.108      P=0.079      P=0.050     |                                                    | 
|POLY 3             |     P=0.110      P=0.071      P=0.057      P=0.041 *   |                                                    | 
|POLY 1.5           |     P=0.111      P=0.072      P=0.063      P=0.041 *   |                                                    | 
|POLY 6             |     P=0.113      P=0.070      P=0.052      P=0.041 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.125      P=0.074      P=0.066      P=0.061     |                                                    | 
|COCH-ARM / FISHERS |     P=0.120      P=0.074      P=0.074      P=0.045 *   |                                                    | 
|ORDER RESTRICTED   |     P=0.040 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  10/50 (20%)  17/50 (34%)  19/50 (38%) |                                                    | 
|POLY-3 RATE (b)    |     15/47.57     10/47.35     17/46.93     19/45.64    |                                                    | 
|POLY-3 PERCENT (g) |     31.5%        21.1%        36.2%        41.6%       |                                                    | 
|TERMINAL (d)       |     9/35 (26%)   7/40 (18%)   12/36 (33%)  14/35 (40%) |                                                    | 
|FIRST INCIDENCE    |     572          548          392          562         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.069      P=0.142N     P=0.430      P=0.258     |                                                    | 
|POLY 3             |     P=0.059      P=0.179N     P=0.396      P=0.212     |                                                    | 
|POLY 1.5           |     P=0.066      P=0.177N     P=0.407      P=0.228     |                                                    | 
|POLY 6             |     P=0.054      P=0.180N     P=0.382      P=0.200     |                                                    | 
|LOGISTIC REGRESSION|     P=0.093      P=0.177N     P=0.443      P=0.243     |                                                    | 
|COCH-ARM / FISHERS |     P=0.085      P=0.178N     P=0.415      P=0.263     |                                                    | 
|ORDER RESTRICTED   |     P=0.085      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Epithelium                                                                                                             | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    0/50 (0%)    5/50 (10%)  |                                                    | 
|POLY-3 RATE (b)    |     4/46.13      2/45.93      0/44.49      5/44.78     |                                                    | 
|POLY-3 PERCENT (g) |     8.7%         4.4%         0.0%         11.2%       |                                                    | 
|TERMINAL (d)       |     4/35 (11%)   2/40 (5%)    0/36 (0%)    3/35 (9%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          598         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.206      P=0.277N     P=0.059N     P=0.489     |                                                    | 
|POLY 3             |     P=0.222      P=0.339N     P=0.065N     P=0.482     |                                                    | 
|POLY 1.5           |     P=0.223      P=0.338N     P=0.063N     P=0.486     |                                                    | 
|POLY 6             |     P=0.221      P=0.339N     P=0.066N     P=0.481     |                                                    | 
|LOGISTIC REGRESSION|     P=0.219      P=0.277N     (e)          P=0.492     |                                                    | 
|COCH-ARM / FISHERS |     P=0.231      P=0.339N     P=0.059N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.134      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands: Duct                                                                                                            | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      0/43.91     |0/46.00      0/44.59      0/40.77      2/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.054      (e)          (e)          P=0.249      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.243      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.252      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.249      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.033 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      1/43.91     |0/46.00      0/44.99      0/40.77      4/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |0.0%         0.0%         0.0%         8.3%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    1/35 (3%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    4/42 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      (e)          (e)          P=0.500     |P=0.005 **   (e)          (e)          P=0.070      | 
|POLY 3             |     P=0.207      (e)          (e)          P=0.490     |P=0.003 **   (e)          (e)          P=0.066      | 
|POLY 1.5           |     P=0.209      (e)          (e)          P=0.493     |P=0.003 **   (e)          (e)          P=0.064      | 
|POLY 6             |     P=0.205      (e)          (e)          P=0.487     |P=0.003 **   (e)          (e)          P=0.069      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.500     |(e)          (e)          (e)          P=0.070      | 
|COCH-ARM / FISHERS |     P=0.214      (e)          (e)          P=0.500     |P=0.003 **   (e)          (e)          P=0.059      | 
|ORDER RESTRICTED   |     P=0.111      (e)          (e)          (e)         |P=0.002 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/49 (2%)    1/48 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.45      0/45.35      2/44.72      1/44.36     |0/46.00      1/44.59      1/39.85      0/48.02      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         4.5%         2.3%        |0.0%         2.2%         2.5%         0.0%         | 
|TERMINAL (d)       |     1/35 (3%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    1/39 (3%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     643          ---          696          598         |---          729 (T)      641          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.619N     P=0.230N     P=0.688      P=0.521N    |P=0.560N     P=0.495      P=0.465      (e)          | 
|POLY 3             |     P=0.603N     P=0.238N     P=0.688      P=0.509N    |P=0.564N     P=0.494      P=0.471      (e)          | 
|POLY 1.5           |     P=0.599N     P=0.237N     P=0.693      P=0.503N    |P=0.568N     P=0.495      P=0.479      (e)          | 
|POLY 6             |     P=0.607N     P=0.237N     P=0.686      P=0.513N    |P=0.559N     P=0.494      P=0.462      (e)          | 
|LOGISTIC REGRESSION|     P=0.561N     P=0.241N     P=0.684N     P=0.460N    |P=0.579N     P=0.495      P=0.527      (e)          | 
|COCH-ARM / FISHERS |     P=0.588N     P=0.247N     P=0.684N     P=0.492N    |P=0.574N     P=0.495      P=0.490      (e)          | 
|ORDER RESTRICTED   |     P=0.422N     (e)          (e)          (e)         |P=0.374N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    4/49 (8%)    1/50 (2%)    6/50 (12%)  |6/50 (12%)   8/49 (16%)   5/48 (10%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/46.06      4/46.84      1/44.70      6/45.07     |6/47.33      8/45.63      5/41.23      4/48.02      | 
|POLY-3 PERCENT (g) |     8.7%         8.5%         2.2%         13.3%       |12.7%        17.5%        12.1%        8.3%         | 
|TERMINAL (d)       |     3/35 (9%)    1/40 (3%)    0/36 (0%)    3/35 (9%)   |4/40 (10%)   5/39 (13%)   2/28 (7%)    4/42 (10%)   | 
|FIRST INCIDENCE    |     315          507          673          395         |328          538          332          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      P=0.603N     P=0.181N     P=0.368     |P=0.202N     P=0.372      P=0.588      P=0.344N     | 
|POLY 3             |     P=0.230      P=0.634N     P=0.188N     P=0.356     |P=0.196N     P=0.358      P=0.596N     P=0.361N     | 
|POLY 1.5           |     P=0.236      P=0.639N     P=0.183N     P=0.363     |P=0.200N     P=0.361      P=0.570N     P=0.366N     | 
|POLY 6             |     P=0.224      P=0.623N     P=0.189N     P=0.353     |P=0.191N     P=0.362      P=0.624      P=0.353N     | 
|LOGISTIC REGRESSION|     P=0.356      P=0.658N     P=0.139N     P=0.458     |P=0.221N     P=0.387      P=0.350N     P=0.444N     | 
|COCH-ARM / FISHERS |     P=0.250      P=0.643N     P=0.175N     P=0.383     |P=0.201N     P=0.371      P=0.529N     P=0.370N     | 
|ORDER RESTRICTED   |     P=0.186      (e)          (e)          (e)         |P=0.248N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/48 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.14      1/45.35      2/44.49      0/43.91     |0/46.00      0/44.59      0/39.53      0/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    2/36 (6%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.531N     P=0.527      P=0.244      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.528N     P=0.501      P=0.234      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.522N     P=0.501      P=0.237      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.534N     P=0.502      P=0.232      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.527      P=0.244      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.509N     P=0.500      P=0.253      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.322      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    2/50 (4%)    3/50 (6%)   |3/50 (6%)    2/49 (4%)    4/48 (8%)    27/50 (54%)  | 
|POLY-3 RATE (b)    |     0/45.14      0/45.35      2/44.49      3/43.91     |3/46.00      2/44.59      4/40.29      27/48.54     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         6.8%        |6.5%         4.5%         9.9%         55.6%        | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    2/36 (6%)    3/35 (9%)   |3/40 (8%)    2/39 (5%)    1/28 (4%)    24/42 (57%)  | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |729 (T)      729 (T)      638          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.031 *    (e)          P=0.244      P=0.121     |P<0.001 **   P=0.512N     P=0.351      P<0.001 **   | 
|POLY 3             |     P=0.033 *    (e)          P=0.234      P=0.114     |P<0.001 **   P=0.514N     P=0.428      P<0.001 **   | 
|POLY 1.5           |     P=0.034 *    (e)          P=0.237      P=0.117     |P<0.001 **   P=0.512N     P=0.446      P<0.001 **   | 
|POLY 6             |     P=0.031 *    (e)          P=0.232      P=0.111     |P<0.001 **   P=0.514N     P=0.409      P<0.001 **   | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.244      P=0.121     |P<0.001 **   P=0.512N     P=0.445      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.038 *    (e)          P=0.253      P=0.125     |P<0.001 **   P=0.510N     P=0.477      P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.034 *    (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Diverticulum                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    1/49 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.13      1/45.93      2/44.49      1/42.91     |1/46.00      1/44.99      0/40.77      2/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         4.5%         2.3%        |2.2%         2.2%         0.0%         4.2%         | 
|TERMINAL (d)       |     1/35 (3%)    1/40 (3%)    2/36 (6%)    1/34 (3%)   |1/40 (3%)    1/39 (3%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.635      P=0.732N     P=0.510      P=0.755     |P=0.381      P=0.756      P=0.571N     P=0.517      | 
|POLY 3             |     P=0.632      P=0.760      P=0.487      P=0.744     |P=0.376      P=0.756      P=0.524N     P=0.515      | 
|POLY 1.5           |     P=0.639      P=0.760      P=0.492      P=0.748     |P=0.373      P=0.757      P=0.515N     P=0.509      | 
|POLY 6             |     P=0.625      P=0.760      P=0.485      P=0.741     |P=0.381      P=0.755      P=0.536N     P=0.522      | 
|LOGISTIC REGRESSION|     P=0.635      P=0.732N     P=0.510      P=0.755     |P=0.381      P=0.756      (e)          P=0.517      | 
|COCH-ARM / FISHERS |     P=0.648N     P=0.753N     P=0.500      P=0.747     |P=0.369      P=0.753N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.563      (e)          (e)          (e)         |P=0.297      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    4/49 (8%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.42      1/46.07      1/44.54      4/44.34     |0/46.00      2/45.29      1/41.38      1/48.18      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         2.3%         9.0%        |0.0%         4.4%         2.4%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    1/34 (3%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     689          693          717          395         |---          680          532          689          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.114      P=0.506N     P=0.508N     P=0.320     |P=0.544      P=0.240      P=0.487      P=0.523      | 
|POLY 3             |     P=0.116      P=0.503N     P=0.514N     P=0.316     |P=0.546      P=0.234      P=0.479      P=0.509      | 
|POLY 1.5           |     P=0.118      P=0.501N     P=0.509N     P=0.320     |P=0.538      P=0.235      P=0.487      P=0.506      | 
|POLY 6             |     P=0.115      P=0.504N     P=0.519N     P=0.313     |P=0.557      P=0.234      P=0.469      P=0.514      | 
|LOGISTIC REGRESSION|     P=0.160      P=0.502N     P=0.501N     P=0.397     |P=0.507      P=0.240      P=0.611      P=0.485      | 
|COCH-ARM / FISHERS |     P=0.121      P=0.500N     P=0.500N     P=0.329     |P=0.527      P=0.247      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.121      (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 59      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    0/50 (0%)    6/49 (12%)  |3/50 (6%)    1/50 (2%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.61      3/46.27      0/44.49      6/44.34     |3/46.71      1/45.18      4/42.96      1/48.02      | 
|POLY-3 PERCENT (g) |     4.3%         6.5%         0.0%         13.5%       |6.4%         2.2%         9.3%         2.1%         | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    0/36 (0%)    2/34 (6%)   |1/40 (3%)    0/39 (0%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     638          675          ---          598         |605          680          532          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    P=0.502      P=0.252N     P=0.123     |P=0.356N     P=0.317N     P=0.418      P=0.288N     | 
|POLY 3             |     P=0.045 *    P=0.497      P=0.248N     P=0.117     |P=0.345N     P=0.317N     P=0.454      P=0.296N     | 
|POLY 1.5           |     P=0.046 *    P=0.499      P=0.244N     P=0.120     |P=0.353N     P=0.313N     P=0.472      P=0.299N     | 
|POLY 6             |     P=0.045 *    P=0.496      P=0.251N     P=0.116     |P=0.336N     P=0.322N     P=0.432      P=0.292N     | 
|LOGISTIC REGRESSION|     P=0.062      P=0.495      P=0.223N     P=0.152     |P=0.403N     P=0.292N     P=0.651N     P=0.342N     | 
|COCH-ARM / FISHERS |     P=0.050      P=0.500      P=0.247N     P=0.128     |P=0.367N     P=0.309N     P=0.500      P=0.309N     | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    0/49 (0%)   |0/49 (0%)    1/49 (2%)    1/48 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/47.53      1/46.16      1/44.98      0/42.91     |0/45.49      1/44.70      1/39.61      0/48.02      | 
|POLY-3 PERCENT (g) |     8.4%         2.2%         2.2%         0.0%        |0.0%         2.2%         2.5%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/34 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     572          668          583          ---         |---          702          710          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.082N     P=0.196N     P=0.206N     P=0.080N    |P=0.558N     P=0.495      P=0.436      (e)          | 
|POLY 3             |     P=0.076N     P=0.188N     P=0.196N     P=0.074N    |P=0.564N     P=0.497      P=0.472      (e)          | 
|POLY 1.5           |     P=0.075N     P=0.184N     P=0.189N     P=0.070N    |P=0.566N     P=0.498      P=0.481      (e)          | 
|POLY 6             |     P=0.078N     P=0.192N     P=0.203N     P=0.080N    |P=0.560N     P=0.496      P=0.462      (e)          | 
|LOGISTIC REGRESSION|     P=0.042N*    P=0.192N     P=0.133N     P=0.041N*   |P=0.567N     P=0.500      P=0.471      (e)          | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.181N     P=0.181N     P=0.061N    |P=0.571N     P=0.500      P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.016N*    (e)          (e)          (e)         |P=0.374N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 60      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |1/49 (2%)    0/49 (0%)    0/48 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.77      0/45.93      0/44.49      0/42.91     |1/45.75      0/44.59      0/39.53      0/48.02      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/34 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     638          ---          ---          ---         |658          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.259N     P=0.252N     P=0.255N     P=0.268N    |P=0.317N     P=0.505N     P=0.541N     P=0.482N     | 
|POLY 3             |     P=0.242N     P=0.241N     P=0.249N     P=0.257N    |P=0.326N     P=0.505N     P=0.529N     P=0.490N     | 
|POLY 1.5           |     P=0.243N     P=0.239N     P=0.244N     P=0.251N    |P=0.324N     P=0.503N     P=0.519N     P=0.492N     | 
|POLY 6             |     P=0.241N     P=0.243N     P=0.253N     P=0.263N    |P=0.328N     P=0.507N     P=0.541N     P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.211N     P=0.254N     P=0.217N     P=0.208N    |P=0.319N     P=0.495N     P=0.479N     P=0.530N     | 
|COCH-ARM / FISHERS |     P=0.245N     P=0.247N     P=0.247N     P=0.253N    |P=0.319N     P=0.500N     P=0.505N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.036N*    (e)          (e)          (e)         |P=0.111N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Glands                                                                                                       | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/49 (0%)    0/49 (0%)    0/48 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.18      0/45.93      0/44.49      0/42.91     |0/45.49      0/44.59      0/39.53      2/48.02      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/34 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     716          ---          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491N     P=0.490N     P=0.505N     P=0.516N    |P=0.054      (e)          (e)          P=0.249      | 
|POLY 3             |     P=0.475N     P=0.501N     P=0.507N     P=0.515N    |P=0.047 *    (e)          (e)          P=0.250      | 
|POLY 1.5           |     P=0.476N     P=0.500N     P=0.505N     P=0.511N    |P=0.047 *    (e)          (e)          P=0.247      | 
|POLY 6             |     P=0.474N     P=0.501N     P=0.509N     P=0.518N    |P=0.048 *    (e)          (e)          P=0.253      | 
|LOGISTIC REGRESSION|     P=0.486N     P=0.501N     P=0.507N     P=0.516N    |(e)          (e)          (e)          P=0.249      | 
|COCH-ARM / FISHERS |     P=0.478N     P=0.500N     P=0.500N     P=0.505N    |P=0.047 *    (e)          (e)          P=0.253      | 
|ORDER RESTRICTED   |     P=0.134N     (e)          (e)          (e)         |P=0.034 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 61      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   15/50 (30%)  13/50 (26%) |                                                    | 
|POLY-3 RATE (b)    |     7/46.33      7/45.93      15/45.35     13/44.42    |                                                    | 
|POLY-3 PERCENT (g) |     15.1%        15.2%        33.1%        29.3%       |                                                    | 
|TERMINAL (d)       |     4/35 (11%)   7/40 (18%)   10/36 (28%)  9/35 (26%)  |                                                    | 
|FIRST INCIDENCE    |     694          729 (T)      644          689         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.053      P=0.523N     P=0.059      P=0.108     |                                                    | 
|POLY 3             |     P=0.049 *    P=0.607      P=0.036 *    P=0.083     |                                                    | 
|POLY 1.5           |     P=0.054      P=0.610      P=0.038 *    P=0.089     |                                                    | 
|POLY 6             |     P=0.046 *    P=0.604      P=0.036 *    P=0.079     |                                                    | 
|LOGISTIC REGRESSION|     P=0.046 *    P=0.603N     P=0.035 *    P=0.076     |                                                    | 
|COCH-ARM / FISHERS |     P=0.070      P=0.613N     P=0.045 *    P=0.105     |                                                    | 
|ORDER RESTRICTED   |     P=0.046 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Bilateral                                                                                                                | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.32      3/45.93      2/44.63      0/43.91     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         6.5%         4.5%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    3/40 (8%)    1/36 (3%)    0/35 (0%)   |                                                    | 
|FIRST INCIDENCE    |     694          729 (T)      694          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.538      P=0.688      P=0.260N    |                                                    | 
|POLY 3             |     P=0.128N     P=0.496      P=0.680      P=0.249N    |                                                    | 
|POLY 1.5           |     P=0.124N     P=0.499      P=0.685      P=0.245N    |                                                    | 
|POLY 6             |     P=0.131N     P=0.494      P=0.677      P=0.253N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.126N     P=0.499      P=0.688      P=0.242N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.500      P=0.691N     P=0.247N    |                                                    | 
|ORDER RESTRICTED   |     P=0.143N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 62      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Bilateral, Interstitial Cell                                                                                             | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/44.49      2/43.91     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    2/35 (6%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    (e)          (e)          P=0.238     |                                                    | 
|POLY 3             |     P=0.038 *    (e)          (e)          P=0.226     |                                                    | 
|POLY 1.5           |     P=0.039 *    (e)          (e)          P=0.230     |                                                    | 
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.223     |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.238     |                                                    | 
|COCH-ARM / FISHERS |     P=0.042 *    (e)          (e)          P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.026 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/47.08      3/46.60      1/44.49      1/44.42     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         6.4%         2.3%         2.3%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    1/40 (3%)    1/36 (3%)    0/35 (0%)   |                                                    | 
|FIRST INCIDENCE    |     572          608          729 (T)      574         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.322N     P=0.501      P=0.517N     P=0.525N    |                                                    | 
|POLY 3             |     P=0.314N     P=0.495      P=0.520N     P=0.520N    |                                                    | 
|POLY 1.5           |     P=0.308N     P=0.498      P=0.512N     P=0.513N    |                                                    | 
|POLY 6             |     P=0.319N     P=0.495      P=0.527N     P=0.527N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.225N     P=0.465      P=0.466N     P=0.405N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.296N     P=0.500      P=0.500N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.354N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 63      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.13      2/45.93      1/44.49      1/43.91     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.3%         2.3%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    1/36 (3%)    1/35 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.602      P=0.268      P=0.506      P=0.500     |                                                    | 
|POLY 3             |     P=0.599      P=0.236      P=0.493      P=0.490     |                                                    | 
|POLY 1.5           |     P=0.605      P=0.237      P=0.495      P=0.493     |                                                    | 
|POLY 6             |     P=0.594      P=0.236      P=0.491      P=0.487     |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.268      P=0.506      P=0.500     |                                                    | 
|COCH-ARM / FISHERS |     P=0.619      P=0.247      P=0.500      P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.271      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    4/50 (8%)    11/50 (22%) |                                                    | 
|POLY-3 RATE (b)    |     1/46.26      4/46.93      4/44.98      11/44.51    |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         8.5%         8.9%         24.7%       |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    2/40 (5%)    3/36 (8%)    9/35 (26%)  |                                                    | 
|FIRST INCIDENCE    |     694          548          583          598         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.197      P=0.183      P=0.003 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.183      P=0.170      P<0.001 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.182      P=0.173      P=0.002 **  |                                                    | 
|POLY 6             |     P<0.001 **   P=0.186      P=0.168      P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.163      P=0.182      P=0.002 **  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.181      P=0.181      P=0.002 **  |                                                    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 64      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/44 (0%)    0/49 (0%)   |0/48 (0%)    0/45 (0%)    2/49 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/44.39      0/43.93      0/40.49      0/43.06     |0/44.00      0/41.15      2/40.53      0/47.15      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.9%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/38 (0%)    0/33 (0%)    0/35 (0%)   |0/38 (0%)    0/37 (0%)    0/27 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          548          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.584      (e)          P=0.207      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.620      (e)          P=0.219      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.607      (e)          P=0.228      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.634      (e)          P=0.209      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.569      (e)          P=0.294      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.585      (e)          P=0.253      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.233      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/48 (2%)    1/44 (2%)    0/49 (0%)   |1/48 (2%)    1/45 (2%)    0/49 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     2/44.39      1/43.93      1/40.49      0/43.06     |1/44.43      1/41.86      0/39.77      2/47.15      | 
|POLY-3 PERCENT (g) |     4.5%         2.3%         2.5%         0.0%        |2.3%         2.4%         0.0%         4.2%         | 
|TERMINAL (d)       |     2/35 (6%)    1/38 (3%)    1/33 (3%)    0/35 (0%)   |0/38 (0%)    0/37 (0%)    0/27 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |602          483          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.201N     P=0.471N     P=0.521N     P=0.238N    |P=0.389      P=0.753      P=0.532N     P=0.528      | 
|POLY 3             |     P=0.201N     P=0.504N     P=0.532N     P=0.244N    |P=0.387      P=0.747      P=0.522N     P=0.521      | 
|POLY 1.5           |     P=0.199N     P=0.501N     P=0.531N     P=0.240N    |P=0.386      P=0.747      P=0.512N     P=0.515      | 
|POLY 6             |     P=0.203N     P=0.506N     P=0.533N     P=0.247N    |P=0.390      P=0.749      P=0.535N     P=0.527      | 
|LOGISTIC REGRESSION|     P=0.201N     P=0.471N     P=0.521N     (e)         |P=0.350      P=0.757      P=0.434N     P=0.476      | 
|COCH-ARM / FISHERS |     P=0.192N     P=0.500N     P=0.533N     P=0.242N    |P=0.383      P=0.736      P=0.495N     P=0.508      | 
|ORDER RESTRICTED   |     P=0.123N     (e)          (e)          (e)         |P=0.306      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 65      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/48 (85%)  43/46 (93%)  38/43 (88%)  34/50 (68%) |48/49 (98%)  46/48 (96%)  40/42 (95%)  25/48 (52%)  | 
|POLY-3 RATE (b)    |     41/47.64     43/45.63     38/42.68     34/47.78    |48/48.51     46/47.09     40/41.05     25/47.36     | 
|POLY-3 PERCENT (g) |     86.1%        94.2%        89.0%        71.2%       |99.0%        97.7%        97.5%        52.8%        | 
|TERMINAL (d)       |     30/35 (86%)  38/39 (97%)  32/35 (91%)  24/35 (69%) |40/40 (100%) 39/39 (100%) 28/28 (100%) 22/41 (54%)  | 
|FIRST INCIDENCE    |     572          507          471          491         |328          483          244          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.104N     P=0.455N     P=0.373N     P=0.182N    |P<0.001N**   P=0.519N     P=0.150      P<0.001N**   | 
|POLY 3             |     P=0.003N**   P=0.158      P=0.457      P=0.059N    |P<0.001N**   P=0.647N     P=0.641N     P<0.001N**   | 
|POLY 1.5           |     P=0.002N**   P=0.167      P=0.458      P=0.052N    |P<0.001N**   P=0.592N     P=0.535N     P<0.001N**   | 
|POLY 6             |     P=0.002N**   P=0.145      P=0.456      P=0.061N    |P<0.001N**   P=0.686N     P=0.864N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.002N**   P=0.176      P=0.460      P=0.050N    |P<0.001N**   P=0.502N     P=0.573N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.176      P=0.460      P=0.035N*   |P<0.001N**   P=0.492N     P=0.442N     P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.004N**   (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/46 (0%)    0/43 (0%)    1/50 (2%)   |0/49 (0%)    2/48 (4%)    1/42 (2%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/45.21      0/43.50      0/40.29      1/43.91     |0/45.28      2/43.78      1/35.80      0/46.81      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         2.3%        |0.0%         4.6%         2.8%         0.0%         | 
|TERMINAL (d)       |     0/35 (0%)    0/39 (0%)    0/35 (0%)    1/35 (3%)   |0/40 (0%)    2/39 (5%)    0/28 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     689          ---          ---          729 (T)     |---          729 (T)      668          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527      P=0.505N     P=0.510N     P=0.755     |P=0.420N     P=0.233      P=0.458      (e)          | 
|POLY 3             |     P=0.534      P=0.508N     P=0.523N     P=0.754     |P=0.418N     P=0.230      P=0.453      (e)          | 
|POLY 1.5           |     P=0.539      P=0.508N     P=0.523N     P=0.759     |P=0.424N     P=0.231      P=0.459      (e)          | 
|POLY 6             |     P=0.528      P=0.506N     P=0.521N     P=0.750     |P=0.412N     P=0.229      P=0.448      (e)          | 
|LOGISTIC REGRESSION|     P=0.545      P=0.499N     P=0.507N     P=0.763     |P=0.427N     P=0.233      P=0.485      (e)          | 
|COCH-ARM / FISHERS |     P=0.550      P=0.511N     P=0.527N     P=0.742N    |P=0.433N     P=0.242      P=0.462      (e)          | 
|ORDER RESTRICTED   |     P=0.399      (e)          (e)          (e)         |P=0.287N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 66      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/48 (100%) 45/46 (98%)  43/43 (100%) 49/50 (98%) |42/49 (86%)  47/48 (98%)  41/42 (98%)  48/48 (100%) | 
|POLY-3 RATE (b)    |     48/48.00     45/45.77     43/43.00     49/49.31    |42/46.64     47/47.20     41/41.04     48/48.00     | 
|POLY-3 PERCENT (g) |     100.0%       98.3%        100.0%       99.4%       |90.1%        99.6%        99.9%        100.0%       | 
|TERMINAL (d)       |     35/35 (100%) 39/39 (100%) 35/35 (100%) 35/35 (100%)|38/40 (95%)  39/39 (100%) 28/28 (100%) 41/41 (100%) | 
|FIRST INCIDENCE    |     572          507          471          249         |602          483          332          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.146      P=0.089N     (e)          P=0.435     |P=0.211      P=0.085      P=0.005 **   P=0.163      | 
|POLY 3             |     P=0.833      P=0.608N     (e)          P=0.988N    |P=0.007 **   P=0.031 *    P=0.036 *    P=0.022 *    | 
|POLY 1.5           |     P=0.700N     P=0.547N     (e)          P=0.794N    |P=0.004 **   P=0.028 *    P=0.030 *    P=0.014 *    | 
|POLY 6             |     P=0.835      P=0.746N     (e)          P=1.000N    |P=0.018 *    P=0.048 *    P=0.062      P=0.043 *    | 
|LOGISTIC REGRESSION|     P=0.723N     P=0.522N     (e)          P=0.771N    |P=0.003 **   P=0.008 **   P=0.006 **   P=0.063      | 
|COCH-ARM / FISHERS |     P=0.479N     P=0.489N     (e)          P=0.510N    |P=0.006 **   P=0.032 *    P=0.048 *    P=0.007 **   | 
|ORDER RESTRICTED   |     P=0.411N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    17/46 (37%)  37/43 (86%)  43/50 (86%) |0/49 (0%)    41/48 (85%)  34/42 (81%)  46/48 (96%)  | 
|POLY-3 RATE (b)    |     0/45.06      17/43.50     37/41.51     43/49.31    |0/45.28      41/46.66     34/38.28     46/47.79     | 
|POLY-3 PERCENT (g) |     0.0%         39.1%        89.1%        87.2%       |0.0%         87.9%        88.8%        96.3%        | 
|TERMINAL (d)       |     0/35 (0%)    17/39 (44%)  33/35 (94%)  31/35 (89%) |0/40 (0%)    36/39 (92%)  27/28 (96%)  40/41 (98%)  | 
|FIRST INCIDENCE    |     ---          729 (T)      538          249         |---          425          332          638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 67      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.13      0/45.93      0/43.72      0/43.91     |0/46.00      0/44.59      0/40.34      2/48.02      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/35 (0%)    0/40 (0%)    0/36 (0%)    0/35 (0%)   |0/40 (0%)    0/39 (0%)    0/28 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.054      (e)          (e)          P=0.249      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.243      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.252      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.249      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.033 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |3/46.42      0/44.99      1/41.10      1/48.02      | 
|POLY-3 PERCENT (g) |                                                        |6.5%         0.0%         2.4%         2.1%         | 
|TERMINAL (d)       |                                                        |2/40 (5%)    0/39 (0%)    0/28 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |                                                        |605          ---          638          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.320N     P=0.129N     P=0.397N     P=0.289N     | 
|POLY 3             |                                                        |P=0.318N     P=0.124N     P=0.350N     P=0.293N     | 
|POLY 1.5           |                                                        |P=0.322N     P=0.122N     P=0.332N     P=0.298N     | 
|POLY 6             |                                                        |P=0.314N     P=0.126N     P=0.373N     P=0.288N     | 
|LOGISTIC REGRESSION|                                                        |P=0.329N     P=0.118N     P=0.285N     P=0.319N     | 
|COCH-ARM / FISHERS |                                                        |P=0.326N     P=0.121N     P=0.309N     P=0.309N     | 
|ORDER RESTRICTED   |                                                        |P=0.100N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/14/03                           EXPERIMENT: 92012 TEST: 05                                            Page 68      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    2-METHYLIMIDAZOLE                   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.00      0/44.99      2/40.77      0/48.02      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         4.9%         0.0%         | 
|TERMINAL (d)       |                                                        |0/40 (0%)    0/39 (0%)    2/28 (7%)    0/42 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.576      (e)          P=0.164      (e)          | 
|POLY 3             |                                                        |P=0.613      (e)          P=0.211      (e)          | 
|POLY 1.5           |                                                        |P=0.599      (e)          P=0.221      (e)          | 
|POLY 6             |                                                        |P=0.628      (e)          P=0.199      (e)          | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          P=0.164      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.575      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.223      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0PPM         300 PPM      1000 PPM     3000 PPM    |0PPM         1000 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |10/50 (20%)  14/50 (28%)  15/50 (30%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |                                                        |10/46.22     14/45.70     15/40.77     15/48.66     | 
|POLY-3 PERCENT (g) |                                                        |21.6%        30.6%        36.8%        30.8%        | 
|TERMINAL (d)       |                                                        |9/40 (23%)   13/39 (33%)  15/28 (54%)  13/42 (31%)  | 
|FIRST INCIDENCE    |                                                        |671          483          729 (T)      638          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.215      P=0.220      P=0.019 *    P=0.225      | 
|POLY 3             |                                                        |P=0.231      P=0.228      P=0.091      P=0.217      | 
|POLY 1.5           |                                                        |P=0.211      P=0.234      P=0.121      P=0.201      | 
|POLY 6             |                                                        |P=0.261      P=0.223      P=0.060      P=0.240      | 
|LOGISTIC REGRESSION|                                                        |P=0.244      P=0.220      P=0.031 *    P=0.210      | 
|COCH-ARM / FISHERS |                                                        |P=0.187      P=0.241      P=0.178      P=0.178      | 
|ORDER RESTRICTED   |                                                        |P=0.148      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.