Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3185

TDMS Study 92012-06 Pathology Tables

NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03
Route: DOSED FEED                                                                                                 Time: 14:41:02

                                                   27 WEEK SSAC/FINAL#1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  693-98-1

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03    
Route: DOSED FEED                                                                                                 Time: 14:41:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         625 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          60           60           60           60                                     
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
      Infiltration Cellular, Mixed Cell                6 (60%)      7 (70%)      3 (30%)      5 (50%)                               
      Necrosis, Focal                                               1 (10%)                                                         
      Hepatocyte, Vacuolization Cytoplasmic                         1 (10%)      2 (20%)      4 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                2 (20%)                                1 (10%)                               
   Thyroid Gland                                      (8)          (10)         (10)         (10)                                   
      Follicular Cell, Hypertrophy                                  8 (80%)     10 (100%)    10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                             1 (10%)      1 (10%)                                                         
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Cystic                              3 (30%)      1 (10%)      4 (40%)      1 (10%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03    
Route: DOSED FEED                                                                                                 Time: 14:41:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0PPM         625 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Pigmentation                                     2 (20%)      1 (10%)                   2 (20%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 2 (20%)      5 (50%)      6 (60%)     10 (100%)                              
      Pigmentation                                     1 (10%)      3 (30%)      7 (70%)     10 (100%)                              
      Lymphoid Follicle, Atrophy                                                              4 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic                            1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                                                   1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Nephropathy                                      1 (10%)      1 (10%)                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03    
Route: DOSED FEED                                                                                                 Time: 14:41:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         625 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          60           60           60           60                                     
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                                           1 (10%)                                            
      Infiltration Cellular, Mixed Cell                2 (20%)      3 (30%)      6 (60%)      2 (20%)                               
      Necrosis, Focal                                               1 (10%)                                                         
      Hepatocyte, Karyomegaly                                                                 5 (50%)                               
      Hepatocyte, Vacuolization Cytoplasmic                                                   4 (40%)                               
   Mesentery                                                                                 (1)                                    
      Fat, Necrosis                                                                           1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)                                   
      Valve, Hypertrophy                                            1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                2 (20%)                                1 (10%)                               
      Hyperplasia, Focal                                                                      1 (10%)                               
      Hypertrophy, Focal                                            1 (10%)                                                         
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicle, Cyst                                                                          1 (10%)                               
      Follicular Cell, Hypertrophy                                  5 (50%)      9 (90%)     10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03    
Route: DOSED FEED                                                                                                 Time: 14:41:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         625 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                                                                    1 (10%)                               
      Inflammation, Chronic                                                      1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)                                   
      Hyperplasia                                      1 (10%)                   2 (20%)      5 (50%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              5 (50%)     10 (100%)    10 (100%)                              
      Pigmentation                                                  1 (10%)     10 (100%)    10 (100%)                              
      Lymphoid Follicle, Atrophy                                                 5 (50%)     10 (100%)                              
      Lymphoid Follicle, Hyperplasia                   1 (10%)                                                                      
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                       1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hemorrhage                                                                 1 (10%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         2-METHYLIMIDAZOLE                                     Date: 02/24/03    
Route: DOSED FEED                                                                                                 Time: 14:41:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0PPM         625 PPM      1250 PPM     2500 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Cyst                                                          1 (10%)                                                         
      Hydronephrosis                                   1 (10%)      1 (10%)                                                         
      Nephropathy                                      1 (10%)                   1 (10%)      2 (20%)                               
      Renal Tubule, Pigmentation                                                 1 (10%)     10 (100%)                              
   Urinary Bladder                                    (10)         (10)         (10)         (10)                                   
      Transitional Epithelium, Hyperplasia             1 (10%)                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------