Share This:
https://ntp.niehs.nih.gov/go/3197

TDMS Study 92012-06 Pathology Tables

NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 15:09:13

                                                   27 WEEK SSAC/FINAL#1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  693-98-1

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 15:09:13    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0PPM         625 PPM      1250 PPM     2500 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          60           60           60           60                                     
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Infiltration Cellular, Mixed Cell                6 [1.0]      7 [1.0]      3 [1.0]      5 [1.0]                               
      Necrosis, Focal                                               1 [1.0]                                                         
      Hepatocyte, Vacuolization Cytoplasmic                         1 [2.0]      2 [2.0]      4 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                2 [3.0]                                1 [3.0]                               
   Thyroid Gland                                      (8)          (10)         (10)         (10)                                   
      Follicular Cell, Hypertrophy                                  8 [1.0]     10 [1.1]     10 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                             1 [3.0]      1 [3.0]                                                         
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Cystic                              3 [1.7]      1 [2.0]      4 [2.3]      1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 15:09:13    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0PPM         625 PPM      1250 PPM     2500 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Pigmentation                                     2 [2.0]      1 [2.0]                   2 [2.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 2 [1.0]      5 [1.2]      6 [1.5]     10 [2.6]                               
      Pigmentation                                     1 [1.0]      3 [1.0]      7 [1.3]     10 [1.9]                               
      Lymphoid Follicle, Atrophy                                                              4 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic                            1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                                                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Nephropathy                                      1 [1.0]      1 [1.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 15:09:13    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0PPM         625 PPM      1250 PPM     2500 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          60           60           60           60                                     
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                                           1 [1.0]                                            
      Infiltration Cellular, Mixed Cell                2 [1.0]      3 [1.0]      6 [1.0]      2 [1.0]                               
      Necrosis, Focal                                               1 [1.0]                                                         
      Hepatocyte, Karyomegaly                                                                 5 [1.2]                               
      Hepatocyte, Vacuolization Cytoplasmic                                                   4 [2.0]                               
   Mesentery                                                                                 (1)                                    
      Fat, Necrosis                                                                           1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)                                   
      Valve, Hypertrophy                                            1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                2 [3.0]                                1 [3.0]                               
      Hyperplasia, Focal                                                                      1 [2.0]                               
      Hypertrophy, Focal                                            1 [2.0]                                                         
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicle, Cyst                                                                          1 [3.0]                               
      Follicular Cell, Hypertrophy                                  5 [1.0]      9 [1.2]     10 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 15:09:13    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0PPM         625 PPM      1250 PPM     2500 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                                                                    1 [3.0]                               
      Inflammation, Chronic                                                      1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)                                   
      Hyperplasia                                      1 [3.0]                   2 [2.0]      5 [1.8]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              5 [1.0]     10 [2.1]     10 [3.0]                               
      Pigmentation                                                  1 [1.0]     10 [1.1]     10 [2.2]                               
      Lymphoid Follicle, Atrophy                                                 5 [1.2]     10 [1.0]                               
      Lymphoid Follicle, Hyperplasia                   1 [1.0]                                                                      
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                       1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hemorrhage                                                                 1 [2.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 92012-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/24/03    
Route: DOSED FEED                                             2-METHYLIMIDAZOLE                                   Time: 15:09:13    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0PPM         625 PPM      1250 PPM     2500 PPM                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Cyst                                                          1 [4.0]                                                         
      Hydronephrosis                                   1 [2.0]      1 [2.0]                                                         
      Nephropathy                                      1 [1.0]                   1 [1.0]      2 [1.0]                               
      Renal Tubule, Pigmentation                                                 1 [1.0]     10 [2.2]                               
   Urinary Bladder                                    (10)         (10)         (10)         (10)                                   
      Transitional Epithelium, Hyperplasia             1 [2.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------