National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3203

TDMS Study 93005-03 Pathology Tables

NTP Experiment-Test: 93005-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03
Route: DOSED FEED                                                                                                 Time: 14:23:56




       Facility:  National Center for Toxicological Research

       Chemical CAS #:  569-64-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 93005-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03  
Route: DOSED FEED                                                                                                 Time: 14:23:56  
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         FISCHER 344 RATS FEMALE                   0 PPM        100 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
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DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          48           48           48           48                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1            3            1            6                                     
    Moribund Sacrifice                                18           22           15           17                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           23           32           25                                     
                                                                                                                                    
  Animals Examined Microscopically                    48           48           48           48                                     
                                                                                                                                    
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 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (47)         (48)         (47)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Rectum                            (48)         (46)         (48)         (48)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Ileum                             (47)         (46)         (48)         (47)                                   
   Liver                                              (48)         (48)         (48)         (48)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                                        1 (2%)       3 (6%)       3 (6%)                                
      Hepatocellular Adenoma, Multiple                 1 (2%)                                 1 (2%)                                
      Sarcoma, Metastatic, Ovary                                                              1 (2%)                                
   Mesentery                                          (9)          (5)          (2)          (4)                                    
      Carcinoma, Metastatic, Uterus                                 1 (20%)                                                         
      Sarcoma                                          1 (11%)                                                                      
      Sarcoma, Metastatic, Ovary                                                              1 (25%)                               
   Pancreas                                           (48)         (48)         (48)         (48)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
   Salivary Glands                                    (48)         (47)         (48)         (48)                                   
   Tongue                                             (48)         (48)         (48)         (48)                                   
      Sarcoma, Metastatic, Ovary                                                              1 (2%)                                
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
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NTP Experiment-Test: 93005-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03  
Route: DOSED FEED                                                                                                 Time: 14:23:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        100 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (48)         (48)         (48)         (48)                                   
      Sarcoma, Metastatic, Ovary                                                              1 (2%)                                
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (48)         (48)         (48)         (48)                                   
      Adenoma                                          2 (4%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Sarcoma, Metastatic, Ovary                                                              1 (2%)                                
   Adrenal Medulla                                    (47)         (47)         (48)         (48)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                                       1 (2%)                    1 (2%)                                
      Sarcoma, Metastatic, Ovary                                                              1 (2%)                                
   Islets, Pancreatic                                 (48)         (48)         (48)         (48)                                   
      Adenoma                                                       2 (4%)       1 (2%)       1 (2%)                                
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (48)         (47)         (46)         (45)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Pars Distalis, Adenoma                          26 (54%)     36 (77%)     32 (70%)     29 (64%)                               
      Pars Distalis, Carcinoma                                                                1 (2%)                                
   Thyroid Gland                                      (46)         (48)         (47)         (46)                                   
      Sarcoma, Metastatic, Ovary                                                              1 (2%)                                
      C-Cell, Adenoma                                  4 (9%)       5 (10%)      3 (6%)       3 (7%)                                
      C-Cell, Carcinoma                                3 (7%)       1 (2%)       2 (4%)       1 (2%)                                
      Follicular Cell, Adenoma                                                   1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                                                 2 (4%)       1 (2%)                                
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (48)         (47)         (47)                                   
      Adenoma                                          7 (15%)      5 (10%)      8 (17%)      8 (17%)                               
      Carcinoma                                        5 (10%)      1 (2%)       5 (11%)      4 (9%)                                
      Bilateral, Carcinoma                                          1 (2%)       1 (2%)       1 (2%)                                
   Ovary                                              (48)         (48)         (47)         (48)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 93005-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03  
Route: DOSED FEED                                                                                                 Time: 14:23:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        100 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
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GENITAL SYSTEM - cont                                                                                                               
      Carcinoma, Metastatic, Clitoral Gland                                      1 (2%)                                             
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Sarcoma                                                                                 1 (2%)                                
   Uterus                                             (48)         (48)         (48)         (48)                                   
      Polyp Stromal                                   14 (29%)      7 (15%)      5 (10%)     16 (33%)                               
      Sarcoma, Metastatic, Ovary                                                              1 (2%)                                
      Sarcoma Stromal                                  2 (4%)       1 (2%)       1 (2%)                                             
      Schwannoma Malignant                                                                    1 (2%)                                
      Endometrium, Adenoma                                                                    1 (2%)                                
      Endometrium, Carcinoma                                        1 (2%)                                                          
   Vagina                                             (48)         (48)         (48)         (48)                                   
      Sarcoma                                                                                 1 (2%)                                
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (48)         (48)         (48)                                   
   Lymph Node                                         (10)         (7)          (7)          (5)                                    
   Lymph Node, Mandibular                             (47)         (46)         (47)         (48)                                   
   Lymph Node, Mesenteric                             (47)         (47)         (48)         (48)                                   
   Spleen                                             (48)         (48)         (48)         (48)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Hemangiosarcoma                                                                         1 (2%)                                
      Sarcoma, Metastatic, Ovary                                                              1 (2%)                                
   Thymus                                             (40)         (42)         (43)         (40)                                   
      Sarcoma, Metastatic, Ovary                                                              1 (3%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (3%)                                
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (48)         (48)         (48)                                   
      Carcinoma                                        2 (4%)       2 (4%)       1 (2%)       5 (10%)                               
      Fibroadenoma                                    15 (33%)     13 (27%)     12 (25%)      9 (19%)                               
   Skin                                               (48)         (48)         (48)         (48)                                   
      Basal Cell Adenoma                               1 (2%)                                                                       
      Keratoacanthoma                                                            1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                                            2 (4%)                                
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NTP Experiment-Test: 93005-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03  
Route: DOSED FEED                                                                                                 Time: 14:23:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        100 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (48)         (48)         (48)         (48)                                   
      Sarcoma                                                                                 1 (2%)                                
   Skeletal Muscle                                    (48)         (48)         (48)         (48)                                   
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (48)         (48)         (48)                                   
      Oligodendroglioma Malignant                                                             1 (2%)                                
      Ventricle, Carcinoma, Metastatic, Pituitary                                                                                   
          Gland                                                                               1 (2%)                                
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (48)         (48)         (48)         (48)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Sarcoma, Metastatic, Mesentery                   1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Ovary                                                 1 (2%)                                
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)                                    
      Pinna, Neural Crest Tumor                                                               1 (100%)                              
   Eye                                                (47)         (48)         (48)         (48)                                   
   Harderian Gland                                    (47)         (48)         (48)         (48)                                   
      Adenoma                                                                                 1 (2%)                                
   Zymbal's Gland                                     (47)         (48)         (48)         (46)                                   
      Carcinoma                                        1 (2%)                    1 (2%)       2 (4%)                                
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (48)         (48)         (48)                                   
   Urinary Bladder                                    (47)         (48)         (47)         (47)                                   
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
      Transitional Epithelium, Carcinoma                                                      1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 93005-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03  
Route: DOSED FEED                                                                                                 Time: 14:23:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        100 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Papilloma                            1 (2%)                                                          
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(48)        *(48)        *(48)        *(48)                                   
      Leukemia Mononuclear                            19 (40%)     17 (35%)     10 (21%)      1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 93005-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          MALACHITE GREEN                                      Date: 06/18/03  
Route: DOSED FEED                                                                                                 Time: 14:23:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        100 PPM      300 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          48          46          42                                       
     Total Primary Neoplasms                          104          99          94         102                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          42          40          35                                       
     Total Benign Neoplasms                            70          74          69          75                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          24          21          23                                       
     Total Malignant Neoplasms                         34          25          25          26                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           1           5                                       
     Total Metastatic Neoplasm                          2           6           1          17                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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