Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/4170

TDMS Study 93023-07 Pathology Tables

NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01
Route: GAVAGE                                                                                                     Time: 11:14:18

                                                         FINAL #1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  142-83-6

       Lock Date:  02/24/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            4            5            6                                     
    Moribund Sacrifice                                 2            8            8            4                                     
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           37           37           37                                     
    Natural Death                                                                             2                                     
  Missing                                                           1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           49           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (49)         (50)         (50)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Gallbladder                                        (44)         (45)         (47)         (41)                                   
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Intestine Large, Colon                             (46)         (46)         (49)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Intestine Large, Cecum                             (45)         (45)         (47)         (44)                                   
   Intestine Small, Duodenum                          (45)         (44)         (47)         (43)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Ileum                             (43)         (46)         (48)         (44)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Liver                                              (50)         (49)         (50)         (50)                                   
      Cholangiocarcinoma                                            1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       3 (6%)       3 (6%)       4 (8%)                                
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Adenoma                          10 (20%)      3 (6%)      10 (20%)      5 (10%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)                    1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Ito Cell Tumor Benign                                                      1 (2%)       1 (2%)                                
      Ito Cell Tumor Malignant                                                   1 (2%)                                             
      Serosa, Sarcoma, Metastatic, Skeletal Muscle     1 (2%)                                                                       
   Mesentery                                          (31)         (30)         (37)         (25)                                   
      Histiocytic Sarcoma                              1 (3%)       1 (3%)                    1 (4%)                                
      Ito Cell Tumor Malignant, Metastatic, Liver                                1 (3%)                                             
      Sarcoma, Metastatic, Skeletal Muscle             1 (3%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        3 (12%)                               
   Pancreas                                           (47)         (46)         (50)         (47)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        2 (4%)                                
   Salivary Glands                                    (49)         (48)         (48)         (50)                                   
   Stomach, Forestomach                               (48)         (48)         (50)         (48)                                   
      Squamous Cell Carcinoma                                                                 7 (15%)                               
      Squamous Cell Papilloma                          2 (4%)       2 (4%)       9 (18%)     11 (23%)                               
      Squamous Cell Papilloma, Multiple                                          2 (4%)       2 (4%)                                
   Stomach, Glandular                                 (45)         (45)         (48)         (46)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        3 (7%)                                
      Serosa, Sarcoma, Metastatic, Skeletal Muscle     1 (2%)                                                                       
   Tooth                                              (1)                                    (2)                                    
      Peridontal Tissue, Sarcoma                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (48)         (50)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (48)         (49)         (49)                                   
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (47)         (46)         (49)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (46)         (48)         (47)         (50)                                   
      Pars Distalis, Adenoma                           2 (4%)       5 (10%)      7 (15%)      3 (6%)                                
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                         2 (4%)                    1 (2%)       1 (2%)                                
   Thyroid Gland                                      (49)         (46)         (49)         (50)                                   
      Bilateral, Follicular Cell, Adenoma              1 (2%)                                                                       
      Follicular Cell, Carcinoma                                                 2 (4%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
      Sarcoma, Metastatic, Skeletal Muscle             1 (100%)                                                                     
   Tissue NOS                                         (1)          (1)          (2)          (1)                                    
      Fibrosarcoma                                                               1 (50%)                                            
      Abdominal, Sarcoma                                                                      1 (100%)                              
      Thoracic, Sarcoma, Multiple                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (47)         (48)         (48)                                   
      Cystadenoma                                      1 (2%)       1 (2%)       3 (6%)       1 (2%)                                
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                                            2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Luteoma                                          1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Uterus                                             (50)         (49)         (50)         (50)                                   
      Hemangiosarcoma                                                                         2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Leiomyoma                                                                               1 (2%)                                
      Polyp Stromal                                                              1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Endometrium, Adenoma                                                                    1 (2%)                                
      Endometrium, Polyp Stromal                                    1 (2%)       2 (4%)       1 (2%)                                
   Vagina                                                          (1)          (1)          (1)                                    
      Hemangioma                                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (47)         (50)         (48)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node                                         (8)          (9)          (9)          (7)                                    
      Bronchial, Histiocytic Sarcoma                                1 (11%)                                                         
      Iliac, Histiocytic Sarcoma                                    1 (11%)                                                         
      Inguinal, Histiocytic Sarcoma                                 1 (11%)                                                         
      Mediastinal, Histiocytic Sarcoma                 1 (13%)                                1 (14%)                               
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
          Metastatic, Stomach, Forestomach                                                    2 (29%)                               
      Renal, Histiocytic Sarcoma                                    1 (11%)                                                         
   Lymph Node, Mandibular                             (47)         (47)         (48)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (47)         (46)         (49)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                    1 (2%)                                
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Spleen                                             (48)         (47)         (50)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Thymus                                             (44)         (46)         (48)         (46)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (50)         (50)                                   
      Adenoacanthoma                                                             1 (2%)                                             
      Carcinoma                                        1 (2%)       3 (6%)       1 (2%)                                             
   Skin                                               (50)         (49)         (50)         (50)                                   
      Pinna, Fibrous Histiocytoma                                                1 (2%)                                             
      Sebaceous Gland, Pinna, Adenoma                  1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple                   2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (43)         (49)         (49)         (39)                                   
      Osteoma                                          1 (2%)                                                                       
   Skeletal Muscle                                    (6)          (4)          (5)          (2)                                    
      Histiocytic Sarcoma                                           1 (25%)                                                         
      Sarcoma                                          5 (83%)      1 (25%)      2 (40%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (48)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)       3 (6%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                                                1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
      Mediastinum, Histiocytic Sarcoma                              1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Skeletal                                                                                    
          Muscle                                       1 (2%)                                                                       
   Nose                                               (50)         (48)         (50)         (50)                                   
   Trachea                                            (49)         (49)         (50)         (50)                                   
      Peritracheal Tissue, Histiocytic Sarcoma                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (3)          (2)          (2)                                    
      Retrobulbar, Carcinoma, Metastatic,                                                                                           
          Harderian Gland                                                        1 (50%)                                            
   Harderian Gland                                    (8)          (6)          (4)          (1)                                    
      Adenoma                                          7 (88%)      6 (100%)     2 (50%)      1 (100%)                              
      Carcinoma                                                                  2 (50%)                                            
_________________________________________________________________________