National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4170

TDMS Study 93023-07 Pathology Tables

NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01
Route: GAVAGE                                                                                                     Time: 11:14:18

                                                         FINAL #1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  142-83-6

       Lock Date:  02/24/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            4            5            6                                     
    Moribund Sacrifice                                 2            8            8            4                                     
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           37           37           37                                     
    Natural Death                                                                             2                                     
  Missing                                                           1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           49           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (49)         (50)         (50)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Gallbladder                                        (44)         (45)         (47)         (41)                                   
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Intestine Large, Colon                             (46)         (46)         (49)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Intestine Large, Cecum                             (45)         (45)         (47)         (44)                                   
   Intestine Small, Duodenum                          (45)         (44)         (47)         (43)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Ileum                             (43)         (46)         (48)         (44)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Liver                                              (50)         (49)         (50)         (50)                                   
      Cholangiocarcinoma                                            1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       3 (6%)       3 (6%)       4 (8%)                                
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Adenoma                          10 (20%)      3 (6%)      10 (20%)      5 (10%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)                    1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Ito Cell Tumor Benign                                                      1 (2%)       1 (2%)                                
      Ito Cell Tumor Malignant                                                   1 (2%)                                             
      Serosa, Sarcoma, Metastatic, Skeletal Muscle     1 (2%)                                                                       
   Mesentery                                          (31)         (30)         (37)         (25)                                   
      Histiocytic Sarcoma                              1 (3%)       1 (3%)                    1 (4%)                                
      Ito Cell Tumor Malignant, Metastatic, Liver                                1 (3%)                                             
      Sarcoma, Metastatic, Skeletal Muscle             1 (3%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        3 (12%)                               
   Pancreas                                           (47)         (46)         (50)         (47)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        2 (4%)                                
   Salivary Glands                                    (49)         (48)         (48)         (50)                                   
   Stomach, Forestomach                               (48)         (48)         (50)         (48)                                   
      Squamous Cell Carcinoma                                                                 7 (15%)                               
      Squamous Cell Papilloma                          2 (4%)       2 (4%)       9 (18%)     11 (23%)                               
      Squamous Cell Papilloma, Multiple                                          2 (4%)       2 (4%)                                
   Stomach, Glandular                                 (45)         (45)         (48)         (46)                                   
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        3 (7%)                                
      Serosa, Sarcoma, Metastatic, Skeletal Muscle     1 (2%)                                                                       
   Tooth                                              (1)                                    (2)                                    
      Peridontal Tissue, Sarcoma                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (48)         (50)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (48)         (49)         (49)                                   
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (47)         (46)         (49)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (46)         (48)         (47)         (50)                                   
      Pars Distalis, Adenoma                           2 (4%)       5 (10%)      7 (15%)      3 (6%)                                
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                         2 (4%)                    1 (2%)       1 (2%)                                
   Thyroid Gland                                      (49)         (46)         (49)         (50)                                   
      Bilateral, Follicular Cell, Adenoma              1 (2%)                                                                       
      Follicular Cell, Carcinoma                                                 2 (4%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
      Sarcoma, Metastatic, Skeletal Muscle             1 (100%)                                                                     
   Tissue NOS                                         (1)          (1)          (2)          (1)                                    
      Fibrosarcoma                                                               1 (50%)                                            
      Abdominal, Sarcoma                                                                      1 (100%)                              
      Thoracic, Sarcoma, Multiple                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (47)         (48)         (48)                                   
      Cystadenoma                                      1 (2%)       1 (2%)       3 (6%)       1 (2%)                                
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                                            2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Luteoma                                          1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Uterus                                             (50)         (49)         (50)         (50)                                   
      Hemangiosarcoma                                                                         2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Leiomyoma                                                                               1 (2%)                                
      Polyp Stromal                                                              1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Endometrium, Adenoma                                                                    1 (2%)                                
      Endometrium, Polyp Stromal                                    1 (2%)       2 (4%)       1 (2%)                                
   Vagina                                                          (1)          (1)          (1)                                    
      Hemangioma                                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (47)         (50)         (48)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node                                         (8)          (9)          (9)          (7)                                    
      Bronchial, Histiocytic Sarcoma                                1 (11%)                                                         
      Iliac, Histiocytic Sarcoma                                    1 (11%)                                                         
      Inguinal, Histiocytic Sarcoma                                 1 (11%)                                                         
      Mediastinal, Histiocytic Sarcoma                 1 (13%)                                1 (14%)                               
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
          Metastatic, Stomach, Forestomach                                                    2 (29%)                               
      Renal, Histiocytic Sarcoma                                    1 (11%)                                                         
   Lymph Node, Mandibular                             (47)         (47)         (48)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (47)         (46)         (49)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                    1 (2%)                                
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Spleen                                             (48)         (47)         (50)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Thymus                                             (44)         (46)         (48)         (46)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (50)         (50)                                   
      Adenoacanthoma                                                             1 (2%)                                             
      Carcinoma                                        1 (2%)       3 (6%)       1 (2%)                                             
   Skin                                               (50)         (49)         (50)         (50)                                   
      Pinna, Fibrous Histiocytoma                                                1 (2%)                                             
      Sebaceous Gland, Pinna, Adenoma                  1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple                   2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (43)         (49)         (49)         (39)                                   
      Osteoma                                          1 (2%)                                                                       
   Skeletal Muscle                                    (6)          (4)          (5)          (2)                                    
      Histiocytic Sarcoma                                           1 (25%)                                                         
      Sarcoma                                          5 (83%)      1 (25%)      2 (40%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93023-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           2,4-HEXADIENAL                                      Date: 02/15/01  
Route: GAVAGE                                                                                                     Time: 11:14:18  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            30           60           120                                       
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (48)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)       3 (6%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                                                1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
      Mediastinum, Histiocytic Sarcoma                              1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Skeletal                                                                                    
          Muscle                                       1 (2%)                                                                       
   Nose                                               (50)         (48)         (50)         (50)                                   
   Trachea                                            (49)         (49)         (50)         (50)                                   
      Peritracheal Tissue, Histiocytic Sarcoma                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (3)          (2)          (2)                                    
      Retrobulbar, Carcinoma, Metastatic,                                                                                           
          Harderian Gland                                                        1 (50%)                                            
   Harderian Gland                                    (8)          (6)          (4)          (1)                                    
      Adenoma                                          7 (88%)      6 (100%)     2 (50%)      1 (100%)                              
      Carcinoma                                                                  2 (50%)                                            
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