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TDMS Study 93026-07 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Northwest                                     DECALIN                                                 DATE: 08/24/01  
EXPERIMENT: 93026 TEST: 07                                                                                        TIME: 11:41:14    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                        NTP:  C93026      
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                                                              FINAL#1                                                               
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE NORTHWEST LABORATORY                    DECALIN                                                     DATE: 08/24/01    
EXPERIMENT: 93026 TEST: 07                                                                                        TIME: 11:49:27    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: RESPIRATORY EX                                         NTP:  C93026      
CONT: N01-ES-55392                                                                                                CAS: 91-17-8      
                                                                                                                                   
                                                                                                                                    
                                         MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                         
                                              TWO YEAR RESPIRATORY EX STUDY OF DECALIN                                              
=================================================================================================================================== 
WEEK     CONTROL                25 PPM                   50 PPM                   100 PPM                  400 PPM                  
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B       118.2       50       117.8     99.7    50     121.2    102.5    50     120.4    101.9    50     120.7    102.1    20      
  1       118.2       50       117.8     99.7    50     121.2    102.5    50     120.4    101.9    50     120.7    102.1    20      
  5       221.7       50       223.1    100.6    50     231.9    104.6    49     225.1    101.5    50     215.9     97.4    20      
  9       271.1       50       273.7    101.0    50     278.2    102.6    49     274.8    101.4    50     264.2     97.5    20      
 13       315.1       50       313.3     99.4    50     323.3    102.6    49     316.9    100.6    50     308.8     98.0    20      
 17       347.4       50       348.6    100.3    50     357.9    103.0    49     351.2    101.1    50     341.4     98.3    20      
 21       370.1       50       374.7    101.2    50     381.1    103.0    49     377.2    101.9    50     365.9     98.9    20      
 25       394.3       50       399.2    101.2    50     408.0    103.5    49     402.5    102.1    50     387.4     98.3    20      
 29       411.3       50       416.9    101.4    50     427.6    104.0    49     418.2    101.7    50     402.4     97.8    20      
 33       429.8       50       433.3    100.8    50     444.8    103.5    49     437.5    101.8    50     417.2     97.1    20      
 37       441.9       50       446.9    101.1    50     456.9    103.4    49     448.3    101.4    50     424.6     96.1    20      
 41       456.8       50       461.2    101.0    50     472.8    103.5    49     462.0    101.1    50     433.4     94.9    20      
 45       464.8       50       468.2    100.7    50     479.7    103.2    49     468.7    100.8    50     439.2     94.5    20      
 49       471.1       50       477.6    101.4    49     489.2    103.8    49     476.2    101.1    50     444.1     94.3    20      
 53       479.3       50       485.3    101.3    49     497.6    103.8    49     485.3    101.3    50     453.0     94.5    20      
 57       480.7       49       494.2    102.8    49     508.3    105.7    49     495.7    103.1    49     463.4     96.4    20      
 61       488.9       49       499.2    102.1    49     512.0    104.7    49     500.9    102.5    48     464.1     94.9    20      
 65       496.4       48       507.2    102.2    49     518.1    104.4    49     508.0    102.3    48     465.0     93.7    19      
 69       502.3       48       509.7    101.5    49     522.9    104.1    49     513.6    102.2    48     468.6     93.3    19      
 73       501.4       48       510.6    101.8    49     525.2    104.7    49     514.8    102.7    48     469.6     93.7    19      
 77       499.6       48       516.3    103.3    46     525.9    105.3    49     518.8    103.8    46     471.6     94.4    19      
 81       500.1       48       516.1    103.2    45     525.4    105.1    49     515.0    103.0    46     474.2     94.8    19      
 85       506.2       43       522.0    103.1    41     530.1    104.7    48     517.6    102.3    44     476.6     94.2    19      
 89       504.5       41       527.0    104.5    39     528.1    104.7    43     514.3    101.9    41     476.9     94.5    19      
 92       498.6       39       518.5    104.0    39     516.5    103.6    42     513.8    103.0    37     476.2     95.5    19      
 94       498.4       38       522.9    104.9    36     510.1    102.3    41     508.4    102.0    35     468.3     94.0    19      
 96       494.3       37       525.4    106.3    35     506.4    102.4    38     502.2    101.6    34     468.9     94.9    19      
 98       492.0       35       518.7    105.4    33     502.0    102.0    35     491.5     99.9    31     466.6     94.8    19      
100       487.2       33       514.5    105.6    31     502.7    103.2    32     488.5    100.3    26     460.1     94.4    19      
102       494.2       29       508.1    102.8    29     504.8    102.1    29     482.4     97.6    25     460.0     93.1    17      
104       486.1       29       500.9    103.0    26     507.5    104.4    24     476.5     98.0    22     473.8     97.5    14      
TERM. SAC.            28                         23                       23                       20                       14      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                   
                                 TWO YEAR RESPIRATORY EX STUDY OF DECALIN                                                           
==========================================================================================================                          
WEEK     CONTROL                25 PPM                   100 PPM                  400 PPM                                           
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        95.3       50        95.1     99.8    50      96.6    101.4    50      96.6    101.4    50                               
  1        95.3       50        95.1     99.8    50      96.6    101.4    50      96.6    101.4    50                               
  5       144.9       50       146.7    101.2    50     146.7    101.2    50     142.8     98.6    50                               
  9       165.9       50       166.5    100.4    50     167.8    101.1    50     167.5    101.0    50                               
 13       181.4       50       183.4    101.1    50     183.1    100.9    50     184.7    101.8    50                               
 17       191.8       50       192.8    100.5    50     191.1     99.6    49     197.2    102.8    50                               
 21       198.5       50       199.3    100.4    50     197.8     99.6    49     203.8    102.7    50                               
 25       208.5       50       211.3    101.3    50     212.2    101.8    49     216.5    103.8    50                               
 29       216.2       50       218.7    101.2    50     216.9    100.3    49     221.0    102.2    50                               
 33       223.7       50       226.4    101.2    50     224.7    100.4    49     229.3    102.5    50                               
 37       231.3       50       232.5    100.5    50     231.9    100.3    49     234.3    101.3    50                               
 41       242.1       50       243.9    100.7    50     240.6     99.4    49     243.3    100.5    50                               
 45       249.0       50       249.5    100.2    50     248.4     99.8    49     250.3    100.5    50                               
 49       258.4       50       261.9    101.4    50     259.3    100.3    49     257.1     99.5    50                               
 53       272.5       49       272.5    100.0    50     270.0     99.1    48     266.6     97.8    50                               
 57       283.3       49       284.1    100.3    50     282.5     99.7    48     280.7     99.1    50                               
 61       294.0       49       295.6    100.5    50     293.7     99.9    48     287.1     97.7    50                               
 65       304.0       49       303.5     99.8    50     304.3    100.1    48     297.2     97.8    50                               
 69       308.6       49       310.3    100.6    50     310.4    100.6    48     303.1     98.2    50                               
 73       313.5       49       317.6    101.3    49     315.8    100.7    48     308.3     98.3    48                               
 77       319.8       48       323.2    101.1    49     324.0    101.3    48     312.0     97.6    48                               
 81       326.1       48       328.7    100.8    48     328.9    100.9    48     321.5     98.6    46                               
 85       330.7       46       339.5    102.7    48     340.6    103.0    48     331.3    100.2    43                               
 89       340.0       45       341.0    100.3    47     340.1    100.0    48     330.8     97.3    39                               
 92       341.3       45       342.6    100.4    46     342.8    100.4    47     326.3     95.6    37                               
 94       339.3       44       345.6    101.9    45     344.2    101.4    47     329.2     97.0    35                               
 96       341.4       42       348.3    102.0    43     346.7    101.6    45     327.8     96.0    35                               
 98       341.4       39       347.5    101.8    43     348.3    102.0    43     332.1     97.3    35                               
100       342.6       37       339.4     99.1    43     353.6    103.2    41     332.0     96.9    35                               
102       345.9       36       343.5     99.3    42     357.3    103.3    40     333.4     96.4    30                               
104       345.2       33       339.3     98.3    40     355.0    102.8    40     343.3     99.4    28                               
TERM. SAC.            32                         35                       39                       28                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.