https://ntp.niehs.nih.gov/go/3948

TDMS Study 93029-04 Pathology Tables

NTP Experiment-Test: 93029-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03
Route: DOSED FEED                                                                                                 Time: 07:04:42
       Facility:  National Center for Toxicological Research
       Chemical CAS #:  129-73-7
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93029-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03  
Route: DOSED FEED                                                                                                 Time: 07:04:42  
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         C57BL/6N XC3H/HEN MTN-NCTR FEMALE         0 PPM        91 PPM       204 PPM      408 PPM                                   
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          48           48           48           48                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            2            2            5                                     
    Moribund                                           4            5            7            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           41           39           39                                     
  Animals Examined Microscopically                    47           48           47           47                                     
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 ALIMENTARY SYSTEM                                                                                                                  
   Gallbladder                                        (44)         (47)         (44)         (46)                                   
   Intestine Large                                    (46)         (48)         (47)         (46)                                   
   Intestine Small                                    (44)         (47)         (47)         (46)                                   
      Ileum, Sarcoma, Metastatic, Ovary                1 (2%)                                                                       
      Jejunum, Adenoma                                                                        1 (2%)                                
   Liver                                              (47)         (48)         (47)         (47)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma                                                   1 (2%)       2 (4%)                                
      Hepatocellular Adenoma                           3 (6%)       6 (13%)      4 (9%)       8 (17%)                               
      Hepatocellular Adenoma, Two                                                1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    2 (4%)                                
   Pancreas                                           (45)         (48)         (47)         (45)                                   
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Salivary Glands                                    (47)         (48)         (47)         (47)                                   
   Stomach                                            (46)         (48)         (47)         (46)                                   
      Forestomach, Mast Cell Tumor Malignant           1 (2%)                                                                       
      Forestomach, Squamous Cell Carcinoma                                       1 (2%)                                             
      Forestomach, Squamous Cell Papilloma                          2 (4%)       1 (2%)       1 (2%)                                
      Glandular, Sarcoma, Metastatic, Skin                                                    1 (2%)                                
      Glandular, Sarcoma, Metastatic, Skeletal                                                                                      
          Muscle                                                    1 (2%)                                                          
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NTP Experiment-Test: 93029-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03  
Route: DOSED FEED                                                                                                 Time: 07:04:42  
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE         0 PPM        91 PPM       204 PPM      408 PPM                                   
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 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (47)         (48)         (47)         (47)                                   
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
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 ENDOCRINE SYSTEM                                                                                                                   
   Islets, Pancreatic                                 (44)         (48)         (47)         (45)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (41)         (45)         (44)         (46)                                   
      Pars Distalis, Adenoma                           3 (7%)                    1 (2%)       2 (4%)                                
   Thyroid Gland                                      (46)         (48)         (47)         (47)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       1 (2%)                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (46)         (48)         (47)         (44)                                   
      Choriocarcinoma                                                            1 (2%)                                             
      Cystadenocarcinoma                                                         1 (2%)                                             
      Cystadenoma                                                                             1 (2%)                                
      Granulosa Cell Tumor Malignant                                                          1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
      Teratoma Benign                                  2 (4%)                                                                       
   Uterus                                             (46)         (48)         (47)         (46)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Leiomyoma                                        1 (2%)       1 (2%)                                                          
      Sarcoma Stromal                                  2 (4%)                                                                       
   Vagina                                             (45)         (47)         (47)         (46)                                   
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
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NTP Experiment-Test: 93029-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03  
Route: DOSED FEED                                                                                                 Time: 07:04:42  
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE         0 PPM        91 PPM       204 PPM      408 PPM                                   
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 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (46)         (48)         (47)         (46)                                   
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
   Lymph Node                                         (47)         (48)         (47)         (47)                                   
      Lumbar, Histiocytic Sarcoma                      1 (2%)                                                                       
      Mandibular, Histiocytic Sarcoma                  1 (2%)                                                                       
      Mandibular, Mast Cell Tumor Malignant            1 (2%)                                                                       
      Mesenteric, Histiocytic Sarcoma                               1 (2%)                                                          
      Mesenteric, Sarcoma, Metastatic, Skin                                                   2 (4%)                                
   Spleen                                             (45)         (48)         (47)         (45)                                   
      Hemangiosarcoma                                  2 (4%)                                                                       
   Thymus                                             (43)         (45)         (45)         (43)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
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 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (46)         (48)         (47)         (45)                                   
      Adenoacanthoma                                   2 (4%)                    1 (2%)                                             
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)       4 (9%)                                
      Carcinoma, Two                                                             1 (2%)                                             
   Skin                                               (46)         (48)         (45)         (45)                                   
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Mast Cell Tumor Benign                                        1 (2%)                                                          
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                    2 (4%)                                
      Tail, Hemangioma                                                           1 (2%)                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                    (47)         (48)         (47)         (46)                                   
      Sarcoma                                                       1 (2%)                                                          
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NTP Experiment-Test: 93029-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03  
Route: DOSED FEED                                                                                                 Time: 07:04:42  
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE         0 PPM        91 PPM       204 PPM      408 PPM                                   
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 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (47)         (48)         (47)         (47)                                   
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (47)         (48)         (47)         (47)                                   
      Adenoacanthoma, Metastatic, Mammary Gland        2 (4%)                                                                       
      Alveolar/Bronchiolar Adenoma                     3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                                                                       
      Carcinoma, Metastatic, Mammary Gland                                                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                    1 (2%)                                
      Sarcoma, Metastatic, Skin                                                               2 (4%)                                
      Sarcoma, Metastatic, Skeletal Muscle                          1 (2%)                                                          
   Nose                                               (47)         (48)         (47)         (47)                                   
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 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (47)         (48)         (47)         (47)                                   
      Adenocarcinoma                                   1 (2%)                                 1 (2%)                                
      Adenoma                                          2 (4%)       2 (4%)       4 (9%)       4 (9%)                                
      Bilateral, Adenoma                                                                      1 (2%)                                
   Zymbal's Gland                                     (47)         (47)         (46)         (47)                                   
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (47)         (48)         (47)         (47)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Urinary Bladder                                    (46)         (48)         (47)         (44)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
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NTP Experiment-Test: 93029-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03  
Route: DOSED FEED                                                                                                 Time: 07:04:42  
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE         0 PPM        91 PPM       204 PPM      408 PPM                                   
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(47)        *(48)        *(47)        *(47)                                   
      Hemangioma                                       1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                  2 (4%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant                               6 (13%)      5 (10%)     12 (26%)      6 (13%)                               
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     *   Number of animals with any tissue examined microscopically                                                                 
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NTP Experiment-Test: 93029-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        LEUKOMALACHITE GREEN                                   Date: 06/19/03  
Route: DOSED FEED                                                                                                 Time: 07:04:42  
____________________________________________________________________________________________________________________________________
         C57BL/6N XC3H/HEN MTN-NCTR FEMALE         0 PPM        91 PPM       204 PPM      408 PPM                                   
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TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            28          22          26          32                                       
     Total Primary Neoplasms                           48          30          35          41                                       
   Total Animals with Benign Neoplasms                 16          14          13          19                                       
     Total Benign Neoplasms                            17          15          15          20                                       
   Total Animals with Malignant Neoplasms              16          11          18          17                                       
     Total Malignant Neoplasms                         31          15          20          21                                       
   Total Animals with Metastatic Neoplasms              3           1                       4                                       
     Total Metastatic Neoplasm                          3           3                      12                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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