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TDMS Study 96001-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 01/08/03       
EXPERIMENT: 96001 TEST: 05                                                                                     TIME: 12:11:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 64742-88-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             FINAL/RATS                                                             
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 01/08/03       
EXPERIMENT: 96001 TEST: 05                                                                                     TIME: 12:11:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 64742-88-7      
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Salivary Glands                                                                    
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 01/08/03       
EXPERIMENT: 96001 TEST: 05                                                                                     TIME: 12:11:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 64742-88-7      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF               STODDARD SOLVENT (TYPE IIC)                                                                        
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Bone                                   Osteosarcoma                                                                                 
Clitoral/Preputial Gland               Carcinoma or Adenoma                                                                         
Skin                                   Basal Cell Carcinoma                                                                         
Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, malignant or NOS), or Trichoepithelioma                       
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom                                                                                                                 
Testes                                 Adenoma                                                                                      
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Osteosarcoma                                                                                 
                                       Osteosarcoma or Osteoma                                                                      
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Brain                                  Glioma Malignant                                                                             
                                       Oligodendroglioma, Glioma, or Astrocytoma                                                    
Clitoral/Preputial Gland               Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Mammary Gland                          Carcinoma                                                                                    
                                       Fibroadenoma                                                                                 
                                       Fibroma, Fibroadenoma or Adenoma                                                             
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Skin                                   Fibroma                                                                                      
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                STODDARD SOLVENT (TYPE IIC)
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   9/50 (18%)   13/50 (26%)  17/50 (34%) |2/50 (4%)    4/50 (8%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/45.63      9/39.38      13/43.53     17/40.82    |2/44.62      4/43.89      2/44.80      2/41.23      | 
|POLY-3 PERCENT (g) |     11.0%        22.9%        29.9%        41.6%       |4.5%         9.1%         4.5%         4.9%         | 
|TERMINAL (d)       |     3/29 (10%)   5/19 (26%)   5/21 (24%)   7/16 (44%)  |2/36 (6%)    2/30 (7%)    2/32 (6%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     626          605          541          652         |730 (T)      726          730 (T)      606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.050      P=0.015 *    P<0.001 **  |P=0.585      P=0.269      P=0.652      P=0.599      | 
|POLY 3             |     P<0.001 **   P=0.117      P=0.022 *    P<0.001 **  |P=0.490N     P=0.329      P=0.693N     P=0.665      | 
|POLY 1.5           |     P<0.001 **   P=0.148      P=0.026 *    P<0.001 **  |P=0.478N     P=0.334      P=0.693N     P=0.677      | 
|POLY 6             |     P<0.001 **   P=0.081      P=0.019 *    P<0.001 **  |P=0.507N     P=0.321      P=0.693N     P=0.650      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.099      P=0.035 *    P<0.001 **  |P=0.511N     P=0.286      P=0.652      P=0.688      | 
|COCH-ARM / FISHERS |     P=0.002 **   P=0.194      P=0.033 *    P=0.004 **  |P=0.456N     P=0.339      P=0.691N     P=0.691N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.531N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.22      0/38.44      0/41.34      2/40.07     |1/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         5.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |1/36 (3%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     684          ---          ---          565         |730 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.192      P=0.628N     P=0.528N     P=0.409     |P=0.343N     P=0.536N     P=0.523N     P=0.573N     | 
|POLY 3             |     P=0.216      P=0.532N     P=0.518N     P=0.458     |P=0.293N     P=0.503N     P=0.499N     P=0.519N     | 
|POLY 1.5           |     P=0.215      P=0.518N     P=0.510N     P=0.476     |P=0.299N     P=0.502N     P=0.500N     P=0.511N     | 
|POLY 6             |     P=0.216      P=0.553N     P=0.527N     P=0.431     |P=0.284N     P=0.507N     P=0.499N     P=0.529N     | 
|LOGISTIC REGRESSION|     P=0.230      P=0.508N     P=0.495N     P=0.594     |P=0.343N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.214      P=0.500N     P=0.500N     P=0.500     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |P=0.137N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   9/50 (18%)   13/50 (26%)  19/50 (38%) |3/50 (6%)    4/50 (8%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/45.81      9/39.38      13/43.53     19/41.48    |3/44.62      4/43.89      2/44.80      2/41.23      | 
|POLY-3 PERCENT (g) |     13.1%        22.9%        29.9%        45.8%       |6.7%         9.1%         4.5%         4.9%         | 
|TERMINAL (d)       |     3/29 (10%)   5/19 (26%)   5/21 (24%)   7/16 (44%)  |3/36 (8%)    2/30 (7%)    2/32 (6%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     626          605          541          565         |730 (T)      726          730 (T)      606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.081      P=0.029 *    P<0.001 **  |P=0.454N     P=0.412      P=0.554N     P=0.623N     | 
|POLY 3             |     P<0.001 **   P=0.185      P=0.044 *    P<0.001 **  |P=0.348N     P=0.491      P=0.498N     P=0.536N     | 
|POLY 1.5           |     P<0.001 **   P=0.228      P=0.050      P<0.001 **  |P=0.337N     P=0.496      P=0.499N     P=0.522N     | 
|POLY 6             |     P<0.001 **   P=0.133      P=0.038 *    P<0.001 **  |P=0.362N     P=0.482      P=0.498N     P=0.555N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.168      P=0.066      P<0.001 **  |P=0.372N     P=0.439      P=0.554N     P=0.527N     | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.288      P=0.062      P=0.002 **  |P=0.319N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.427N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.04      0/38.44      0/41.34      0/39.41     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/29 (7%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205N     P=0.335N     P=0.311N     P=0.376N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.133N     P=0.274N     P=0.257N     P=0.268N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.140N     P=0.257N     P=0.249N     P=0.254N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.123N     P=0.300N     P=0.267N     P=0.289N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.205N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.152N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Glioma Malignant                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      0/39.41     |0/44.22      0/43.87      0/44.80      2/40.80      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.9%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.031 *    (e)          (e)          P=0.178      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.220      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.228      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.041 *    (e)          (e)          P=0.208      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.038 *    (e)          (e)          P=0.210      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.253      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.024 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.04      0/38.44      0/41.34      0/39.41     |0/44.22      0/43.87      0/44.80      2/40.80      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.9%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.405N     P=0.584N     P=0.564N     P=0.619N    |P=0.031 *    (e)          (e)          P=0.178      | 
|POLY 3             |     P=0.318N     P=0.531N     P=0.517N     P=0.527N    |P=0.043 *    (e)          (e)          P=0.220      | 
|POLY 1.5           |     P=0.329N     P=0.518N     P=0.510N     P=0.515N    |P=0.044 *    (e)          (e)          P=0.228      | 
|POLY 6             |     P=0.302N     P=0.552N     P=0.526N     P=0.543N    |P=0.041 *    (e)          (e)          P=0.208      | 
|LOGISTIC REGRESSION|     P=0.405N     (e)          (e)          (e)         |P=0.038 *    (e)          (e)          P=0.210      | 
|COCH-ARM / FISHERS |     P=0.343N     P=0.500N     P=0.500N     P=0.500N    |P=0.047 *    (e)          (e)          P=0.253      | 
|ORDER RESTRICTED   |     P=0.145N     (e)          (e)          (e)         |P=0.024 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/49 (0%)    3/50 (6%)    5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/45.04      1/38.94      2/41.34      1/39.41     |0/43.62      3/43.87      5/44.98      6/41.15      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         4.8%         2.5%        |0.0%         6.8%         11.1%        14.6%        | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    2/21 (10%)   1/16 (6%)   |0/35 (0%)    3/30 (10%)   4/32 (13%)   4/25 (16%)   | 
|FIRST INCIDENCE    |     ---          579          729 (T)      729 (T)     |---          730 (T)      682          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.265      P=0.487      P=0.170      P=0.381     |P=0.005 **   P=0.095      P=0.029 *    P=0.007 **   | 
|POLY 3             |     P=0.323      P=0.471      P=0.218      P=0.473     |P=0.011 *    P=0.119      P=0.033 *    P=0.012 *    | 
|POLY 1.5           |     P=0.346      P=0.484      P=0.226      P=0.485     |P=0.012 *    P=0.121      P=0.033 *    P=0.014 *    | 
|POLY 6             |     P=0.290      P=0.452      P=0.209      P=0.456     |P=0.009 **   P=0.116      P=0.033 *    P=0.010 *    | 
|LOGISTIC REGRESSION|     P=0.353      P=0.660      P=0.170      P=0.381     |P=0.008 **   P=0.095      P=0.035 *    P=0.013 *    | 
|COCH-ARM / FISHERS |     P=0.373      P=0.500      P=0.247      P=0.500     |P=0.016 *    P=0.125      P=0.030 *    P=0.014 *    | 
|ORDER RESTRICTED   |     P=0.209      (e)          (e)          (e)         |P=0.009 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |1/49 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.82      3/42.30      0/39.41     |1/43.62      2/43.87      1/44.80      1/41.03      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         7.1%         0.0%        |2.3%         4.6%         2.2%         2.4%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |1/35 (3%)    2/30 (7%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          621          396          ---         |730 (T)      730 (T)      730 (T)      625          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.568      P=0.477      P=0.099      (e)         |P=0.618N     P=0.446      P=0.742      P=0.709      | 
|POLY 3             |     P=0.562      P=0.470      P=0.108      (e)         |P=0.546N     P=0.502      P=0.755N     P=0.747      | 
|POLY 1.5           |     P=0.593      P=0.483      P=0.112      (e)         |P=0.538N     P=0.505      P=0.755N     P=0.754      | 
|POLY 6             |     P=0.514      P=0.452      P=0.101      (e)         |P=0.557N     P=0.497      P=0.755N     P=0.737      | 
|LOGISTIC REGRESSION|     P=0.574N     P=0.596      P=0.197      (e)         |P=0.556N     P=0.446      P=0.742      P=0.757N     | 
|COCH-ARM / FISHERS |     P=0.627N     P=0.500      P=0.121      (e)         |P=0.525N     P=0.508      P=0.747N     P=0.747N     | 
|ORDER RESTRICTED   |     P=0.209      (e)          (e)          (e)         |P=0.598N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    5/50 (10%)   1/50 (2%)   |1/49 (2%)    5/50 (10%)   6/50 (12%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     0/45.04      2/39.32      5/42.30      1/39.41     |1/43.62      5/43.87      6/44.98      7/41.52      | 
|POLY-3 PERCENT (g) |     0.0%         5.1%         11.8%        2.5%        |2.3%         11.4%        13.3%        16.9%        | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    3/21 (14%)   1/16 (6%)   |1/35 (3%)    5/30 (17%)   5/32 (16%)   4/25 (16%)   | 
|FIRST INCIDENCE    |     ---          579          396          729 (T)     |730 (T)      730 (T)      682          606          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.290      P=0.220      P=0.019 *    P=0.381     |P=0.012 *    P=0.070      P=0.049 *    P=0.013 *    | 
|POLY 3             |     P=0.327      P=0.208      P=0.025 *    P=0.473     |P=0.029 *    P=0.102      P=0.060      P=0.024 *    | 
|POLY 1.5           |     P=0.363      P=0.220      P=0.028 *    P=0.485     |P=0.034 *    P=0.104      P=0.060      P=0.027 *    | 
|POLY 6             |     P=0.275      P=0.191      P=0.022 *    P=0.456     |P=0.025 *    P=0.098      P=0.061      P=0.021 *    | 
|LOGISTIC REGRESSION|     P=0.443      P=0.365      P=0.045 *    P=0.381     |P=0.024 *    P=0.070      P=0.061      P=0.027 *    | 
|COCH-ARM / FISHERS |     P=0.408      P=0.247      P=0.028 *    P=0.500     |P=0.042 *    P=0.107      P=0.059      P=0.032 *    | 
|ORDER RESTRICTED   |     P=0.082      (e)          (e)          (e)         |P=0.021 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    3/50 (6%)   |1/49 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.30      2/38.66      1/41.43      3/40.22     |1/44.22      0/43.87      1/44.85      0/40.65      | 
|POLY-3 PERCENT (g) |     6.6%         5.2%         2.4%         7.5%        |2.3%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    0/21 (0%)    1/16 (6%)   |1/36 (3%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     674          670          708          578         |730 (T)      ---          718          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.431      P=0.643      P=0.391N     P=0.477     |P=0.466N     P=0.536N     P=0.741      P=0.573N     | 
|POLY 3             |     P=0.535      P=0.572N     P=0.338N     P=0.606     |P=0.413N     P=0.502N     P=0.758N     P=0.517N     | 
|POLY 1.5           |     P=0.544      P=0.540N     P=0.324N     P=0.631     |P=0.409N     P=0.499N     P=0.757N     P=0.508N     | 
|POLY 6             |     P=0.520      P=0.617N     P=0.355N     P=0.570     |P=0.418N     P=0.506N     P=0.759N     P=0.528N     | 
|LOGISTIC REGRESSION|     P=0.534      P=0.611N     P=0.342N     P=0.654N    |P=0.443N     (e)          P=0.762      (e)          | 
|COCH-ARM / FISHERS |     P=0.555      P=0.500N     P=0.309N     P=0.661N    |P=0.402N     P=0.495N     P=0.747N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.460      (e)          (e)          (e)         |P=0.268N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      0/38.44      3/41.79      0/39.41     |0/44.22      0/43.87      1/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         7.2%         0.0%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          621          ---         |---          ---          730 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.589      P=0.584N     P=0.223      P=0.619N    |P=0.657      (e)          P=0.477      (e)          | 
|POLY 3             |     P=0.589N     P=0.531N     P=0.279      P=0.527N    |P=0.652      (e)          P=0.503      (e)          | 
|POLY 1.5           |     P=0.577N     P=0.518N     P=0.289      P=0.515N    |P=0.671      (e)          P=0.503      (e)          | 
|POLY 6             |     P=0.608N     P=0.552N     P=0.266      P=0.543N    |P=0.626      (e)          P=0.501      (e)          | 
|LOGISTIC REGRESSION|     P=0.593N     (e)          P=0.284      (e)         |(e)          (e)          P=0.477      (e)          | 
|COCH-ARM / FISHERS |     P=0.564N     P=0.500N     P=0.309      P=0.500N    |P=0.697      (e)          P=0.505      (e)          | 
|ORDER RESTRICTED   |     P=0.266N     (e)          (e)          (e)         |P=0.384      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    4/50 (8%)    3/50 (6%)   |1/49 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.30      2/38.66      4/41.88      3/40.22     |1/44.22      0/43.87      2/44.85      0/40.65      | 
|POLY-3 PERCENT (g) |     8.8%         5.2%         9.6%         7.5%        |2.3%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     2/29 (7%)    1/19 (5%)    1/21 (5%)    1/16 (6%)   |1/36 (3%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     674          670          621          578         |730 (T)      ---          718          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.419      P=0.570N     P=0.506      P=0.589     |P=0.541N     P=0.536N     P=0.466      P=0.573N     | 
|POLY 3             |     P=0.555      P=0.412N     P=0.600      P=0.565N    |P=0.485N     P=0.502N     P=0.505      P=0.517N     | 
|POLY 1.5           |     P=0.568      P=0.379N     P=0.617      P=0.536N    |P=0.474N     P=0.499N     P=0.506      P=0.508N     | 
|POLY 6             |     P=0.533      P=0.464N     P=0.578      P=0.605N    |P=0.500N     P=0.506N     P=0.503      P=0.528N     | 
|LOGISTIC REGRESSION|     P=0.550      P=0.473N     P=0.601      P=0.514N    |P=0.518N     (e)          P=0.495      (e)          | 
|COCH-ARM / FISHERS |     P=0.564N     P=0.339N     P=0.643N     P=0.500N    |P=0.457N     P=0.495N     P=0.508      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.630      (e)          (e)          (e)         |P=0.342N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/49 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.04      0/38.44      2/41.34      0/38.70     |0/44.22      0/43.87      0/44.80      1/40.84      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.8%         0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    2/21 (10%)   0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          ---          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.642N     P=0.584N     P=0.387      P=0.619N    |P=0.179      (e)          (e)          P=0.468      | 
|POLY 3             |     P=0.536N     P=0.531N     P=0.470      P=0.530N    |P=0.189      (e)          (e)          P=0.484      | 
|POLY 1.5           |     P=0.530N     P=0.518N     P=0.482      P=0.519N    |P=0.193      (e)          (e)          P=0.492      | 
|POLY 6             |     P=0.547N     P=0.552N     P=0.455      P=0.546N    |P=0.183      (e)          (e)          P=0.473      | 
|LOGISTIC REGRESSION|     P=0.642N     (e)          P=0.387      (e)         |P=0.202      (e)          (e)          P=0.506      | 
|COCH-ARM / FISHERS |     P=0.524N     P=0.500N     P=0.500      P=0.505N    |P=0.200      (e)          (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.326N     (e)          (e)          (e)         |P=0.107      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    0/49 (0%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.04      0/38.44      3/41.34      0/38.70     |0/44.22      0/43.87      1/44.98      1/40.84      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         7.3%         0.0%        |0.0%         0.0%         2.2%         2.5%         | 
|TERMINAL (d)       |     2/29 (7%)    0/19 (0%)    3/21 (14%)   0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          682          682          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.525N     P=0.335N     P=0.353      P=0.376N    |P=0.209      (e)          P=0.514      P=0.468      | 
|POLY 3             |     P=0.389N     P=0.274N     P=0.461      P=0.272N    |P=0.213      (e)          P=0.503      P=0.484      | 
|POLY 1.5           |     P=0.383N     P=0.257N     P=0.477      P=0.259N    |P=0.223      (e)          P=0.504      P=0.492      | 
|POLY 6             |     P=0.401N     P=0.300N     P=0.441      P=0.293N    |P=0.200      (e)          P=0.503      P=0.473      | 
|LOGISTIC REGRESSION|     P=0.525N     (e)          P=0.353      (e)         |P=0.242      (e)          P=0.506      P=0.506      | 
|COCH-ARM / FISHERS |     P=0.378N     P=0.247N     P=0.500      P=0.253N    |P=0.238      (e)          P=0.505      P=0.505      | 
|ORDER RESTRICTED   |     P=0.182N     (e)          (e)          (e)         |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |4/50 (8%)    2/50 (4%)    10/50 (20%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     0/45.04      1/38.44      2/41.34      0/39.41     |4/44.62      2/44.08      10/46.61     8/42.08      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         4.8%         0.0%        |9.0%         4.5%         21.5%        19.0%        | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    2/21 (10%)   0/16 (0%)   |4/36 (11%)   1/30 (3%)    6/32 (19%)   3/25 (12%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |730 (T)      675          401          537          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.590      P=0.416      P=0.170      (e)         |P=0.019 *    P=0.413N     P=0.058      P=0.080      | 
|POLY 3             |     P=0.636N     P=0.469      P=0.218      (e)         |P=0.037 *    P=0.343N     P=0.085      P=0.148      | 
|POLY 1.5           |     P=0.617N     P=0.482      P=0.226      (e)         |P=0.042 *    P=0.340N     P=0.080      P=0.159      | 
|POLY 6             |     P=0.603      P=0.448      P=0.209      (e)         |P=0.033 *    P=0.348N     P=0.089      P=0.134      | 
|LOGISTIC REGRESSION|     (e)          P=0.416      P=0.170      (e)         |P=0.056      P=0.356N     P=0.074      P=0.154      | 
|COCH-ARM / FISHERS |     P=0.592N     P=0.500      P=0.247      (e)         |P=0.053      P=0.339N     P=0.074      P=0.178      | 
|ORDER RESTRICTED   |     P=0.304      (e)          (e)          (e)         |P=0.046 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/50 (4%)    4/50 (8%)   |19/50 (38%)  26/50 (52%)  22/50 (44%)  24/50 (48%)  | 
|POLY-3 RATE (b)    |     3/45.04      1/38.44      2/41.34      4/39.68     |19/47.60     26/45.52     22/45.47     24/42.64     | 
|POLY-3 PERCENT (g) |     6.7%         2.6%         4.8%         10.1%       |39.9%        57.1%        48.4%        56.3%        | 
|TERMINAL (d)       |     3/29 (10%)   1/19 (5%)    2/21 (10%)   2/16 (13%)  |12/36 (33%)  18/30 (60%)  16/32 (50%)  16/25 (64%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      691         |481          481          689          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.111      P=0.465N     P=0.647N     P=0.230     |P=0.040 *    P=0.054      P=0.248      P=0.030 *    | 
|POLY 3             |     P=0.236      P=0.364N     P=0.539N     P=0.431     |P=0.126      P=0.069      P=0.269      P=0.085      | 
|POLY 1.5           |     P=0.243      P=0.338N     P=0.523N     P=0.461     |P=0.182      P=0.087      P=0.297      P=0.126      | 
|POLY 6             |     P=0.225      P=0.405N     P=0.559N     P=0.389     |P=0.075      P=0.049 *    P=0.236      P=0.049 *    | 
|LOGISTIC REGRESSION|     P=0.153      P=0.465N     P=0.647N     P=0.304     |P=0.174      P=0.111      P=0.344      P=0.151      | 
|COCH-ARM / FISHERS |     P=0.249      P=0.309N     P=0.500N     P=0.500     |P=0.290      P=0.114      P=0.342      P=0.210      | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |P=0.086      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/50 (4%)    4/50 (8%)   |19/50 (38%)  26/50 (52%)  23/50 (46%)  24/50 (48%)  | 
|POLY-3 RATE (b)    |     3/45.04      1/38.44      2/41.34      4/39.68     |19/47.60     26/45.52     23/45.49     24/42.64     | 
|POLY-3 PERCENT (g) |     6.7%         2.6%         4.8%         10.1%       |39.9%        57.1%        50.6%        56.3%        | 
|TERMINAL (d)       |     3/29 (10%)   1/19 (5%)    2/21 (10%)   2/16 (13%)  |12/36 (33%)  18/30 (60%)  16/32 (50%)  16/25 (64%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      691         |481          481          689          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.111      P=0.465N     P=0.647N     P=0.230     |P=0.038 *    P=0.054      P=0.196      P=0.030 *    | 
|POLY 3             |     P=0.236      P=0.364N     P=0.539N     P=0.431     |P=0.118      P=0.069      P=0.203      P=0.085      | 
|POLY 1.5           |     P=0.243      P=0.338N     P=0.523N     P=0.461     |P=0.173      P=0.087      P=0.229      P=0.126      | 
|POLY 6             |     P=0.225      P=0.405N     P=0.559N     P=0.389     |P=0.069      P=0.049 *    P=0.174      P=0.049 *    | 
|LOGISTIC REGRESSION|     P=0.153      P=0.465N     P=0.647N     P=0.304     |P=0.165      P=0.111      P=0.273      P=0.151      | 
|COCH-ARM / FISHERS |     P=0.249      P=0.309N     P=0.500N     P=0.500     |P=0.282      P=0.114      P=0.272      P=0.210      | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |P=0.086      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    4/50 (8%)    4/50 (8%)   |23/50 (46%)  27/50 (54%)  28/50 (56%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     3/45.04      2/38.44      4/41.34      4/39.68     |23/47.60     27/45.73     28/47.28     29/43.52     | 
|POLY-3 PERCENT (g) |     6.7%         5.2%         9.7%         10.1%       |48.3%        59.1%        59.2%        66.6%        | 
|TERMINAL (d)       |     3/29 (10%)   2/19 (11%)   4/21 (19%)   2/16 (13%)  |16/36 (44%)  18/30 (60%)  18/32 (56%)  18/25 (72%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      691         |481          481          401          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.120      P=0.677      P=0.324      P=0.230     |P=0.013 *    P=0.132      P=0.151      P=0.014 *    | 
|POLY 3             |     P=0.265      P=0.572N     P=0.453      P=0.431     |P=0.054      P=0.200      P=0.193      P=0.054      | 
|POLY 1.5           |     P=0.281      P=0.540N     P=0.473      P=0.461     |P=0.083      P=0.231      P=0.201      P=0.086      | 
|POLY 6             |     P=0.241      P=0.618N     P=0.429      P=0.389     |P=0.031 *    P=0.160      P=0.181      P=0.029 *    | 
|LOGISTIC REGRESSION|     P=0.169      P=0.677      P=0.324      P=0.304     |P=0.088      P=0.265      P=0.212      P=0.098      | 
|COCH-ARM / FISHERS |     P=0.298      P=0.500N     P=0.500      P=0.500     |P=0.151      P=0.274      P=0.212      P=0.158      | 
|ORDER RESTRICTED   |     P=0.383      (e)          (e)          (e)         |P=0.051      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     38/50 (76%)  36/50 (72%)  35/50 (70%)  31/50 (62%) |27/49 (55%)  34/50 (68%)  33/50 (66%)  28/50 (56%)  | 
|POLY-3 RATE (b)    |     38/48.92     36/46.13     35/46.55     31/44.67    |27/45.49     34/47.79     33/47.01     28/44.86     | 
|POLY-3 PERCENT (g) |     77.7%        78.1%        75.2%        69.4%       |59.4%        71.2%        70.2%        62.4%        | 
|TERMINAL (d)       |     21/29 (72%)  14/19 (74%)  15/21 (71%)  12/16 (75%) |22/36 (61%)  19/30 (63%)  23/32 (72%)  16/25 (64%)  | 
|FIRST INCIDENCE    |     476          403          529          522         |509          481          565          506          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.307      P=0.056      P=0.248      P=0.136     |P=0.103      P=0.042 *    P=0.079      P=0.069      | 
|POLY 3             |     P=0.162N     P=0.584      P=0.481N     P=0.239N    |P=0.525      P=0.157      P=0.185      P=0.466      | 
|POLY 1.5           |     P=0.116N     P=0.531N     P=0.420N     P=0.166N    |P=0.516N     P=0.146      P=0.179      P=0.494      | 
|POLY 6             |     P=0.249N     P=0.484      P=0.546N     P=0.370N    |P=0.471      P=0.172      P=0.199      P=0.427      | 
|LOGISTIC REGRESSION|     P=0.108N     P=0.495N     P=0.400N     P=0.183N    |P=0.495      P=0.114      P=0.167      P=0.397      | 
|COCH-ARM / FISHERS |     P=0.075N     P=0.410N     P=0.326N     P=0.097N    |P=0.438N     P=0.133      P=0.183      P=0.545      | 
|ORDER RESTRICTED   |     P=0.252N     (e)          (e)          (e)         |P=0.298      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     39/50 (78%)  36/50 (72%)  35/50 (70%)  31/50 (62%) |27/49 (55%)  35/50 (70%)  33/50 (66%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     39/49.14     36/46.13     35/46.55     31/44.67    |27/45.49     35/47.79     33/47.01     29/44.91     | 
|POLY-3 PERCENT (g) |     79.4%        78.1%        75.2%        69.4%       |59.4%        73.2%        70.2%        64.6%        | 
|TERMINAL (d)       |     21/29 (72%)  14/19 (74%)  15/21 (71%)  12/16 (75%) |22/36 (61%)  20/30 (67%)  23/32 (72%)  16/25 (64%)  | 
|FIRST INCIDENCE    |     476          403          529          522         |509          481          565          506          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.346      P=0.072      P=0.294      P=0.169     |P=0.079      P=0.028 *    P=0.079      P=0.048 *    | 
|POLY 3             |     P=0.125N     P=0.539N     P=0.401N     P=0.180N    |P=0.463      P=0.108      P=0.185      P=0.381      | 
|POLY 1.5           |     P=0.086N     P=0.443N     P=0.337N     P=0.116N    |P=0.505      P=0.100      P=0.179      P=0.410      | 
|POLY 6             |     P=0.206N     P=0.556      P=0.477N     P=0.306N    |P=0.410      P=0.118      P=0.199      P=0.343      | 
|LOGISTIC REGRESSION|     P=0.079N     P=0.395N     P=0.307N     P=0.124N    |P=0.428      P=0.077      P=0.167      P=0.314      | 
|COCH-ARM / FISHERS |     P=0.054N     P=0.322N     P=0.247N     P=0.063N    |P=0.496N     P=0.093      P=0.183      P=0.465      | 
|ORDER RESTRICTED   |     P=0.183N     (e)          (e)          (e)         |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.44      1/41.34      3/39.65     |0/44.62      0/43.87      1/44.90      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         2.4%         7.6%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    1/21 (5%)    1/16 (6%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      684         |---          ---          703          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    P=0.416      P=0.436      P=0.055     |P=0.665      (e)          P=0.495      (e)          | 
|POLY 3             |     P=0.048 *    P=0.469      P=0.483      P=0.097     |P=0.653      (e)          P=0.501      (e)          | 
|POLY 1.5           |     P=0.053      P=0.482      P=0.490      P=0.106     |P=0.670      (e)          P=0.501      (e)          | 
|POLY 6             |     P=0.043 *    P=0.448      P=0.474      P=0.085     |P=0.628      (e)          P=0.502      (e)          | 
|LOGISTIC REGRESSION|     P=0.038 *    P=0.416      P=0.436      P=0.079     |P=0.689      (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.059      P=0.500      P=0.500      P=0.121     |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.027 *    (e)          (e)          (e)         |P=0.383      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.44      1/41.34      3/39.65     |0/44.62      0/43.87      1/44.90      1/41.29      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         2.4%         7.6%        |0.0%         0.0%         2.2%         2.4%         | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    1/21 (5%)    1/16 (6%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      684         |---          ---          703          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    P=0.416      P=0.436      P=0.055     |P=0.209      (e)          P=0.495      P=0.496      | 
|POLY 3             |     P=0.048 *    P=0.469      P=0.483      P=0.097     |P=0.216      (e)          P=0.501      P=0.485      | 
|POLY 1.5           |     P=0.053      P=0.482      P=0.490      P=0.106     |P=0.224      (e)          P=0.501      P=0.491      | 
|POLY 6             |     P=0.043 *    P=0.448      P=0.474      P=0.085     |P=0.205      (e)          P=0.502      P=0.476      | 
|LOGISTIC REGRESSION|     P=0.038 *    P=0.416      P=0.436      P=0.079     |P=0.301      (e)          P=0.500      P=0.646      | 
|COCH-ARM / FISHERS |     P=0.059      P=0.500      P=0.500      P=0.121     |P=0.236      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.027 *    (e)          (e)          (e)         |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    5/50 (10%)  |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.04      3/38.78      1/41.34      5/39.65     |1/44.62      0/43.87      1/44.90      1/41.29      | 
|POLY-3 PERCENT (g) |     2.2%         7.7%         2.4%         12.6%       |2.2%         0.0%         2.2%         2.4%         | 
|TERMINAL (d)       |     1/29 (3%)    2/19 (11%)   1/21 (5%)    3/16 (19%)  |1/36 (3%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      636          729 (T)      684         |730 (T)      ---          703          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035 *    P=0.188      P=0.689      P=0.024 *   |P=0.488      P=0.536N     P=0.744      P=0.718      | 
|POLY 3             |     P=0.075      P=0.253      P=0.741      P=0.074     |P=0.517      P=0.503N     P=0.759N     P=0.743      | 
|POLY 1.5           |     P=0.084      P=0.276      P=0.749      P=0.086     |P=0.525      P=0.502N     P=0.760N     P=0.750      | 
|POLY 6             |     P=0.064      P=0.223      P=0.731      P=0.060     |P=0.505      P=0.507N     P=0.759N     P=0.733      | 
|LOGISTIC REGRESSION|     P=0.060      P=0.210      P=0.689      P=0.038 *   |P=0.582      (e)          P=0.762N     P=0.721N     | 
|COCH-ARM / FISHERS |     P=0.096      P=0.309      P=0.753N     P=0.102     |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P=0.511      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.04      4/39.26      2/41.34      2/39.46     |0/44.62      0/43.87      0/44.80      2/41.04      | 
|POLY-3 PERCENT (g) |     4.4%         10.2%        4.8%         5.1%        |0.0%         0.0%         0.0%         4.9%         | 
|TERMINAL (d)       |     2/29 (7%)    2/19 (11%)   2/21 (10%)   1/16 (6%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      579          729 (T)      717         |---          ---          ---          621          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.583N     P=0.201      P=0.575      P=0.472     |P=0.034 *    (e)          (e)          P=0.190      | 
|POLY 3             |     P=0.451N     P=0.276      P=0.663      P=0.646     |P=0.043 *    (e)          (e)          P=0.219      | 
|POLY 1.5           |     P=0.427N     P=0.302      P=0.676      P=0.667     |P=0.044 *    (e)          (e)          P=0.226      | 
|POLY 6             |     P=0.487N     P=0.239      P=0.647      P=0.613     |P=0.041 *    (e)          (e)          P=0.209      | 
|LOGISTIC REGRESSION|     P=0.455N     P=0.289      P=0.575      P=0.506     |P=0.049 *    (e)          (e)          P=0.240      | 
|COCH-ARM / FISHERS |     P=0.397N     P=0.339      P=0.691N     P=0.691N    |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.525      (e)          (e)          (e)         |P=0.024 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/45.04      5/39.26      2/41.34      2/39.46     |0/44.62      0/43.87      4/45.47      2/41.04      | 
|POLY-3 PERCENT (g) |     6.7%         12.7%        4.8%         5.1%        |0.0%         0.0%         8.8%         4.9%         | 
|TERMINAL (d)       |     3/29 (10%)   3/19 (16%)   2/21 (10%)   1/16 (6%)   |0/36 (0%)    0/30 (0%)    1/32 (3%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     729 (T)      579          729 (T)      717         |---          ---          610          621          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.402N     P=0.185      P=0.647N     P=0.609     |P=0.071      (e)          P=0.064      P=0.190      | 
|POLY 3             |     P=0.266N     P=0.283      P=0.539N     P=0.560N    |P=0.079      (e)          P=0.063      P=0.219      | 
|POLY 1.5           |     P=0.246N     P=0.314      P=0.523N     P=0.534N    |P=0.087      (e)          P=0.062      P=0.226      | 
|POLY 6             |     P=0.297N     P=0.240      P=0.559N     P=0.598N    |P=0.069      (e)          P=0.064      P=0.209      | 
|LOGISTIC REGRESSION|     P=0.280N     P=0.251      P=0.647N     P=0.643     |P=0.109      (e)          P=0.063      P=0.240      | 
|COCH-ARM / FISHERS |     P=0.222N     P=0.357      P=0.500N     P=0.500N    |P=0.104      (e)          P=0.059      P=0.247      | 
|ORDER RESTRICTED   |     P=0.331N     (e)          (e)          (e)         |P=0.057      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      1/38.44      0/41.34      0/39.41     |0/44.62      0/43.87      2/45.37      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         2.6%         0.0%         0.0%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          610          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.280N     P=0.665      P=0.564N     P=0.619N    |P=0.570      (e)          P=0.247      (e)          | 
|POLY 3             |     P=0.219N     P=0.724      P=0.517N     P=0.527N    |P=0.541      (e)          P=0.241      (e)          | 
|POLY 1.5           |     P=0.216N     P=0.741      P=0.510N     P=0.515N    |P=0.563      (e)          P=0.239      (e)          | 
|POLY 6             |     P=0.223N     P=0.699      P=0.526N     P=0.543N    |P=0.508      (e)          P=0.243      (e)          | 
|LOGISTIC REGRESSION|     P=0.280N     P=0.665      (e)          (e)         |P=0.631      (e)          P=0.240      (e)          | 
|COCH-ARM / FISHERS |     P=0.212N     P=0.753N     P=0.500N     P=0.500N    |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.249N     (e)          (e)          (e)         |P=0.252      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      1/38.44      0/41.34      0/39.41     |0/44.62      0/43.87      4/45.47      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         2.6%         0.0%         0.0%        |0.0%         0.0%         8.8%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          610          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.280N     P=0.665      P=0.564N     P=0.619N    |P=0.438      (e)          P=0.064      (e)          | 
|POLY 3             |     P=0.219N     P=0.724      P=0.517N     P=0.527N    |P=0.427      (e)          P=0.063      (e)          | 
|POLY 1.5           |     P=0.216N     P=0.741      P=0.510N     P=0.515N    |P=0.457      (e)          P=0.062      (e)          | 
|POLY 6             |     P=0.223N     P=0.699      P=0.526N     P=0.543N    |P=0.387      (e)          P=0.064      (e)          | 
|LOGISTIC REGRESSION|     P=0.280N     P=0.665      (e)          (e)         |P=0.507      (e)          P=0.063      (e)          | 
|COCH-ARM / FISHERS |     P=0.212N     P=0.753N     P=0.500N     P=0.500N    |P=0.500      (e)          P=0.059      (e)          | 
|ORDER RESTRICTED   |     P=0.249N     (e)          (e)          (e)         |P=0.113      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Lipoma                                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.04      0/38.44      0/41.34      1/39.48     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         2.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/29 (7%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          712         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.630N     P=0.335N     P=0.311N     P=0.694N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.493N     P=0.274N     P=0.257N     P=0.546N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.504N     P=0.257N     P=0.249N     P=0.526N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.478N     P=0.300N     P=0.267N     P=0.575N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.591N     (e)          (e)          P=0.653N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.518N     P=0.247N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.165N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      0/38.44      0/41.34      0/39.41     |0/44.62      0/43.87      2/44.90      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    1/32 (3%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          705          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.537      (e)          P=0.221      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.542      (e)          P=0.238      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.564      (e)          P=0.238      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.510      (e)          P=0.239      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.568      (e)          P=0.238      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.250      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      2/38.78      0/41.34      2/39.41     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         5.2%         0.0%         5.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    0/21 (0%)    2/16 (13%)  |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      636          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.382      P=0.383      P=0.564N     P=0.296     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.479      P=0.448      P=0.517N     P=0.454     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.495      P=0.471      P=0.510N     P=0.474     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.455      P=0.415      P=0.526N     P=0.424     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.461      P=0.437      (e)          P=0.296     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.514      P=0.500      P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.353      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      2/38.78      0/41.34      2/39.41     |1/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         5.2%         0.0%         5.1%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    0/21 (0%)    2/16 (13%)  |1/36 (3%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      636          ---          729 (T)     |730 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.382      P=0.383      P=0.564N     P=0.296     |P=0.343N     P=0.536N     P=0.523N     P=0.573N     | 
|POLY 3             |     P=0.479      P=0.448      P=0.517N     P=0.454     |P=0.293N     P=0.503N     P=0.499N     P=0.519N     | 
|POLY 1.5           |     P=0.495      P=0.471      P=0.510N     P=0.474     |P=0.299N     P=0.502N     P=0.500N     P=0.511N     | 
|POLY 6             |     P=0.455      P=0.415      P=0.526N     P=0.424     |P=0.284N     P=0.507N     P=0.499N     P=0.529N     | 
|LOGISTIC REGRESSION|     P=0.461      P=0.437      (e)          P=0.296     |P=0.343N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.514      P=0.500      P=0.500N     P=0.500     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.353      (e)          (e)          (e)         |P=0.137N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      2/38.78      0/41.34      2/39.41     |1/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         5.2%         0.0%         5.1%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    0/21 (0%)    2/16 (13%)  |1/36 (3%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      636          ---          729 (T)     |730 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.382      P=0.383      P=0.564N     P=0.296     |P=0.343N     P=0.536N     P=0.523N     P=0.573N     | 
|POLY 3             |     P=0.479      P=0.448      P=0.517N     P=0.454     |P=0.293N     P=0.503N     P=0.499N     P=0.519N     | 
|POLY 1.5           |     P=0.495      P=0.471      P=0.510N     P=0.474     |P=0.299N     P=0.502N     P=0.500N     P=0.511N     | 
|POLY 6             |     P=0.455      P=0.415      P=0.526N     P=0.424     |P=0.284N     P=0.507N     P=0.499N     P=0.529N     | 
|LOGISTIC REGRESSION|     P=0.461      P=0.437      (e)          P=0.296     |P=0.343N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.514      P=0.500      P=0.500N     P=0.500     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.353      (e)          (e)          (e)         |P=0.137N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Sebaceous Gland                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.47      1/38.44      1/41.34      0/39.41     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     6.6%         2.6%         2.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    1/19 (5%)    1/21 (5%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     670          729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.133N     P=0.499N     P=0.395N     P=0.198N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.090N     P=0.368N     P=0.340N     P=0.146N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.089N     P=0.339N     P=0.325N     P=0.134N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.092N     P=0.412N     P=0.360N     P=0.167N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.106N     P=0.374N     P=0.328N     P=0.125N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.089N     P=0.309N     P=0.309N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.053N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  39/50 (78%)  38/50 (76%)  42/50 (84%) |                                                    | 
|POLY-3 RATE (b)    |     41/47.99     39/45.35     38/47.00     42/46.31    |                                                    | 
|POLY-3 PERCENT (g) |     85.4%        86.0%        80.9%        90.7%       |                                                    | 
|TERMINAL (d)       |     27/29 (93%)  18/19 (95%)  16/21 (76%)  15/16 (94%) |                                                    | 
|FIRST INCIDENCE    |     476          537          509          522         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.018 *    P=0.020 *    P=0.185      P=0.002 **  |                                                    | 
|POLY 3             |     P=0.293      P=0.596      P=0.365N     P=0.300     |                                                    | 
|POLY 1.5           |     P=0.327      P=0.556N     P=0.352N     P=0.375     |                                                    | 
|POLY 6             |     P=0.282      P=0.508      P=0.351N     P=0.243     |                                                    | 
|LOGISTIC REGRESSION|     P=0.193      P=0.327      P=0.499N     P=0.124     |                                                    | 
|COCH-ARM / FISHERS |     P=0.388      P=0.402N     P=0.312N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.243      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   6/50 (12%)   6/50 (12%)   4/50 (8%)   |3/49 (6%)    5/50 (10%)   2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     7/45.57      6/39.56      6/41.86      4/39.93     |3/44.34      5/43.87      2/44.92      4/41.79      | 
|POLY-3 PERCENT (g) |     15.4%        15.2%        14.3%        10.0%       |6.8%         11.4%        4.5%         9.6%         | 
|TERMINAL (d)       |     4/29 (14%)   4/19 (21%)   3/21 (14%)   2/16 (13%)  |2/36 (6%)    5/30 (17%)   1/32 (3%)    2/25 (8%)    | 
|FIRST INCIDENCE    |     670          421          589          652         |698          730 (T)      698          509          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.449N     P=0.424      P=0.533      P=0.563N    |P=0.382      P=0.266      P=0.536N     P=0.361      | 
|POLY 3             |     P=0.269N     P=0.609N     P=0.566N     P=0.341N    |P=0.506      P=0.350      P=0.494N     P=0.468      | 
|POLY 1.5           |     P=0.248N     P=0.559N     P=0.538N     P=0.305N    |P=0.522      P=0.359      P=0.493N     P=0.485      | 
|POLY 6             |     P=0.304N     P=0.553      P=0.601N     P=0.396N    |P=0.484      P=0.336      P=0.497N     P=0.443      | 
|LOGISTIC REGRESSION|     P=0.263N     P=0.559N     P=0.580N     P=0.370N    |P=0.519      P=0.317      P=0.496N     P=0.537      | 
|COCH-ARM / FISHERS |     P=0.222N     P=0.500N     P=0.500N     P=0.262N    |P=0.547      P=0.369      P=0.490N     P=0.511      | 
|ORDER RESTRICTED   |     P=0.374N     (e)          (e)          (e)         |P=0.500      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    2/50 (4%)    0/50 (0%)   |1/49 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.45      3/38.44      2/41.45      0/39.41     |1/44.22      2/44.13      0/44.80      1/40.65      | 
|POLY-3 PERCENT (g) |     4.4%         7.8%         4.8%         0.0%        |2.3%         4.5%         0.0%         2.5%         | 
|TERMINAL (d)       |     1/29 (3%)    3/19 (16%)   1/21 (5%)    0/16 (0%)   |1/36 (3%)    0/30 (0%)    0/32 (0%)    1/25 (4%)    | 
|FIRST INCIDENCE    |     611          729 (T)      702          ---         |730 (T)      691          ---          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.200N     P=0.335      P=0.605      P=0.333N    |P=0.583N     P=0.461      P=0.523N     P=0.678      | 
|POLY 3             |     P=0.140N     P=0.424      P=0.661      P=0.270N    |P=0.510N     P=0.499      P=0.497N     P=0.742      | 
|POLY 1.5           |     P=0.128N     P=0.458      P=0.674      P=0.255N    |P=0.504N     P=0.503      P=0.497N     P=0.751      | 
|POLY 6             |     P=0.161N     P=0.375      P=0.643      P=0.293N    |P=0.516N     P=0.494      P=0.499N     P=0.728      | 
|LOGISTIC REGRESSION|     P=0.141N     P=0.381      P=0.689      P=0.205N    |P=0.533N     P=0.500      (e)          P=0.678      | 
|COCH-ARM / FISHERS |     P=0.114N     P=0.500      P=0.691N     P=0.247N    |P=0.495N     P=0.508      P=0.495N     P=0.747N     | 
|ORDER RESTRICTED   |     P=0.131N     (e)          (e)          (e)         |P=0.398N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   9/50 (18%)   8/50 (16%)   4/50 (8%)   |4/49 (8%)    7/50 (14%)   2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     9/45.98      9/39.56      8/41.97      4/39.93     |4/44.34      7/44.13      2/44.92      4/41.79      | 
|POLY-3 PERCENT (g) |     19.6%        22.8%        19.1%        10.0%       |9.0%         15.9%        4.5%         9.6%         | 
|TERMINAL (d)       |     5/29 (17%)   7/19 (37%)   4/21 (19%)   2/16 (13%)  |3/36 (8%)    5/30 (17%)   1/32 (3%)    2/25 (8%)    | 
|FIRST INCIDENCE    |     611          421          589          652         |698          691          698          509          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252N     P=0.252      P=0.481      P=0.372N    |P=0.551N     P=0.184      P=0.379N     P=0.486      | 
|POLY 3             |     P=0.108N     P=0.463      P=0.583N     P=0.176N    |P=0.410N     P=0.257      P=0.331N     P=0.611      | 
|POLY 1.5           |     P=0.093N     P=0.527      P=0.548N     P=0.147N    |P=0.395N     P=0.265      P=0.330N     P=0.628      | 
|POLY 6             |     P=0.137N     P=0.364      P=0.587      P=0.223N    |P=0.431N     P=0.245      P=0.333N     P=0.585      | 
|LOGISTIC REGRESSION|     P=0.105N     P=0.492      P=0.577N     P=0.167N    |P=0.405N     P=0.237      P=0.333N     P=0.626N     | 
|COCH-ARM / FISHERS |     P=0.076N     P=0.602N     P=0.500N     P=0.117N    |P=0.372N     P=0.274      P=0.329N     P=0.631N     | 
|ORDER RESTRICTED   |     P=0.137N     (e)          (e)          (e)         |P=0.309N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.04      1/38.45      2/41.92      1/39.72     |0/44.22      0/43.87      1/44.81      0/40.65      | 
|POLY-3 PERCENT (g) |     2.2%         2.6%         4.8%         2.5%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/29 (3%)    0/19 (0%)    1/21 (5%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      726          546          645         |---          ---          726          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.470      P=0.665      P=0.418      P=0.671     |P=0.656      (e)          P=0.483      (e)          | 
|POLY 3             |     P=0.537      P=0.724      P=0.475      P=0.732     |P=0.652      (e)          P=0.503      (e)          | 
|POLY 1.5           |     P=0.553      P=0.741      P=0.485      P=0.745     |P=0.671      (e)          P=0.503      (e)          | 
|POLY 6             |     P=0.512      P=0.699      P=0.462      P=0.713     |P=0.626      (e)          P=0.502      (e)          | 
|LOGISTIC REGRESSION|     P=0.573      P=0.655      P=0.542      P=0.763     |P=0.671      (e)          P=0.497      (e)          | 
|COCH-ARM / FISHERS |     P=0.572      P=0.753N     P=0.500      P=0.753N    |P=0.697      (e)          P=0.505      (e)          | 
|ORDER RESTRICTED   |     P=0.546      (e)          (e)          (e)         |P=0.384      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |10/50 (20%)  9/50 (18%)   10/50 (20%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |                                                        |10/45.46     9/44.98      10/45.00     9/41.73      | 
|POLY-3 PERCENT (g) |                                                        |22.0%        20.0%        22.2%        21.6%        | 
|TERMINAL (d)       |                                                        |8/36 (22%)   6/30 (20%)   8/32 (25%)   4/25 (16%)   | 
|FIRST INCIDENCE    |                                                        |582          593          689          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.356      P=0.570      P=0.504      P=0.421      | 
|POLY 3             |                                                        |P=0.535      P=0.510N     P=0.590      P=0.583N     | 
|POLY 1.5           |                                                        |P=0.526N     P=0.505N     P=0.593      P=0.550N     | 
|POLY 6             |                                                        |P=0.491      P=0.522N     P=0.582      P=0.578      | 
|LOGISTIC REGRESSION|                                                        |P=0.549      P=0.505N     P=0.595N     P=0.567N     | 
|COCH-ARM / FISHERS |                                                        |P=0.476N     P=0.500N     P=0.598N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.699      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |11/50 (22%)  10/50 (20%)  10/50 (20%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |                                                        |11/45.53     10/44.99     10/45.00     10/42.00     | 
|POLY-3 PERCENT (g) |                                                        |24.2%        22.2%        22.2%        23.8%        | 
|TERMINAL (d)       |                                                        |8/36 (22%)   6/30 (20%)   8/32 (25%)   4/25 (16%)   | 
|FIRST INCIDENCE    |                                                        |582          593          689          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.355      P=0.556      P=0.594      P=0.405      | 
|POLY 3             |                                                        |P=0.544N     P=0.512N     P=0.512N     P=0.584N     | 
|POLY 1.5           |                                                        |P=0.513N     P=0.506N     P=0.507N     P=0.550N     | 
|POLY 6             |                                                        |P=0.507      P=0.526N     P=0.522N     P=0.571      | 
|LOGISTIC REGRESSION|                                                        |P=0.540N     P=0.507N     P=0.496N     P=0.564N     | 
|COCH-ARM / FISHERS |                                                        |P=0.465N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.671N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     25/50 (50%)  29/50 (58%)  30/50 (60%)  30/50 (60%) |26/50 (52%)  28/50 (56%)  26/50 (52%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     25/47.99     29/44.73     30/47.32     30/45.98    |26/47.29     28/48.20     26/48.19     29/47.32     | 
|POLY-3 PERCENT (g) |     52.1%        64.8%        63.4%        65.3%       |55.0%        58.1%        54.0%        61.3%        | 
|TERMINAL (d)       |     12/29 (41%)  10/19 (53%)  8/21 (38%)   8/16 (50%)  |18/36 (50%)  14/30 (47%)  14/32 (44%)  10/25 (40%)  | 
|FIRST INCIDENCE    |     476          421          509          432         |495          506          433          451          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.048 *    P=0.022 *    P=0.072      P=0.013 *   |P=0.084      P=0.243      P=0.433      P=0.080      | 
|POLY 3             |     P=0.175      P=0.144      P=0.178      P=0.133     |P=0.329      P=0.460      P=0.542N     P=0.339      | 
|POLY 1.5           |     P=0.196      P=0.192      P=0.187      P=0.163     |P=0.328      P=0.442      P=0.558N     P=0.334      | 
|POLY 6             |     P=0.155      P=0.097      P=0.179      P=0.103     |P=0.334      P=0.483      P=0.523N     P=0.348      | 
|LOGISTIC REGRESSION|     P=0.244      P=0.283      P=0.277      P=0.282     |P=0.401      P=0.426      P=0.579      P=0.383      | 
|COCH-ARM / FISHERS |     P=0.224      P=0.274      P=0.211      P=0.211     |P=0.342      P=0.421      P=0.579N     P=0.344      | 
|ORDER RESTRICTED   |     P=0.136      (e)          (e)          (e)         |P=0.424      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.44      0/41.34      2/40.13     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         0.0%         5.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          563         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.133      P=0.416      (e)          P=0.201     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.146      P=0.469      (e)          P=0.212     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.153      P=0.482      (e)          P=0.223     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.135      P=0.448      (e)          P=0.198     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.172      P=0.416      (e)          P=0.327     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.163      P=0.500      (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.059      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.04      1/38.44      0/41.34      2/40.13     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     0.0%         2.6%         0.0%         5.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    1/19 (5%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          563         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.133      P=0.416      (e)          P=0.201     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.146      P=0.469      (e)          P=0.212     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.153      P=0.482      (e)          P=0.223     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.135      P=0.448      (e)          P=0.198     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.172      P=0.416      (e)          P=0.327     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.163      P=0.500      (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.059      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.04      0/38.44      0/41.34      0/39.41     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/29 (7%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205N     P=0.335N     P=0.311N     P=0.376N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.133N     P=0.274N     P=0.257N     P=0.268N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.140N     P=0.257N     P=0.249N     P=0.254N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.123N     P=0.300N     P=0.267N     P=0.289N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.205N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.152N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.04      0/38.44      0/41.34      0/39.41     |0/44.62      0/43.87      0/44.80      0/40.65      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/29 (7%)    0/19 (0%)    0/21 (0%)    0/16 (0%)   |0/36 (0%)    0/30 (0%)    0/32 (0%)    0/25 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205N     P=0.335N     P=0.311N     P=0.376N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.133N     P=0.274N     P=0.257N     P=0.268N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.140N     P=0.257N     P=0.249N     P=0.254N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.123N     P=0.300N     P=0.267N     P=0.289N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.205N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.152N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 49/50 (98%)  48/50 (96%) |37/50 (74%)  47/50 (94%)  42/50 (84%)  43/50 (86%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     49/49.16     48/48.47    |37/48.40     47/49.21     42/47.34     43/47.07     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       99.7%        99.0%       |76.4%        95.5%        88.7%        91.4%        | 
|TERMINAL (d)       |     29/29 (100%) 19/19 (100%) 21/21 (100%) 16/16 (100%)|27/36 (75%)  29/30 (97%)  29/32 (91%)  24/25 (96%)  | 
|FIRST INCIDENCE    |     476          403          509          522         |481          481          565          506          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.053      (e)          P=0.080      P=0.007 **  |P=0.007 **   P=0.008 **   P=0.098      P=0.004 **   | 
|POLY 3             |     P=0.366N     (e)          P=1.000N     P=0.942N    |P=0.058      P=0.005 **   P=0.085      P=0.036 *    | 
|POLY 1.5           |     P=0.117N     (e)          P=0.931N     P=0.514N    |P=0.092      P=0.005 **   P=0.107      P=0.052      | 
|POLY 6             |     P=1.000N     (e)          P=1.000N     P=1.000N    |P=0.037 *    P=0.004 **   P=0.071      P=0.026 *    | 
|LOGISTIC REGRESSION|     P=0.020N*    (e)          (e)          (e)         |P=0.095      P=0.007 **   P=0.159      P=0.054      | 
|COCH-ARM / FISHERS |     P=0.062N     (e)          P=0.500N     P=0.247N    |P=0.205      P=0.006 **   P=0.163      P=0.105      | 
|ORDER RESTRICTED   |     P=0.050N     (e)          (e)          (e)         |P=0.008 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/08/03                           EXPERIMENT: 96001 TEST: 05                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                STODDARD SOLVENT (TYPE IIC) 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  33/50 (66%)  35/50 (70%)  35/50 (70%) |30/50 (60%)  30/50 (60%)  36/50 (72%)  37/50 (74%)  | 
|POLY-3 RATE (b)    |     33/48.45     33/44.73     35/48.27     35/47.54    |30/48.15     30/48.40     36/49.24     37/48.01     | 
|POLY-3 PERCENT (g) |     68.1%        73.8%        72.5%        73.6%       |62.3%        62.0%        73.1%        77.1%        | 
|TERMINAL (d)       |     17/29 (59%)  14/19 (74%)  11/21 (52%)  8/16 (50%)  |20/36 (56%)  15/30 (50%)  21/32 (66%)  15/25 (60%)  | 
|FIRST INCIDENCE    |     476          421          396          432         |495          506          401          451          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.053      P=0.037 *    P=0.117      P=0.022 *   |P=0.008 **   P=0.341      P=0.121      P=0.015 *    | 
|POLY 3             |     P=0.364      P=0.348      P=0.399      P=0.352     |P=0.041 *    P=0.570N     P=0.175      P=0.084      | 
|POLY 1.5           |     P=0.351      P=0.448      P=0.404      P=0.378     |P=0.041 *    P=0.576N     P=0.164      P=0.085      | 
|POLY 6             |     P=0.384      P=0.229      P=0.400      P=0.323     |P=0.042 *    P=0.560N     P=0.184      P=0.088      | 
|LOGISTIC REGRESSION|     P=0.339      P=0.434      P=0.499      P=0.524     |P=0.065      P=0.572N     P=0.143      P=0.111      | 
|COCH-ARM / FISHERS |     P=0.331      P=0.583N     P=0.415      P=0.415     |P=0.050      P=0.581N     P=0.146      P=0.101      | 
|ORDER RESTRICTED   |     P=0.420      (e)          (e)          (e)         |P=0.083      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      138          550          1100        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%)|44/50 (88%)  50/50 (100%) 50/50 (100%) 48/50 (96%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     50/50.00     50/50.00    |44/50.00     50/50.00     50/50.00     48/49.06     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |88.0%        100.0%       100.0%       97.8%        | 
|TERMINAL (d)       |     29/29 (100%) 19/19 (100%) 21/21 (100%) 16/16 (100%)|30/36 (83%)  30/30 (100%) 32/32 (100%) 24/25 (96%)  | 
|FIRST INCIDENCE    |     476          403          396          432         |481          481          401          451          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.009 **   P=0.038 *    P=0.075      P=0.010 *    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.029 *    P=0.016 *    P=0.016 *    P=0.063      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.037 *    P=0.016 *    P=0.016 *    P=0.073      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.026 *    P=0.016 *    P=0.016 *    P=0.060      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.098      (e)          (e)          P=0.121      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.111      P=0.013 *    P=0.013 *    P=0.134      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).