National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4839

TDMS Study 96001-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 09/25/02       
EXPERIMENT: 96001 TEST: 06                                                                                     TIME: 11:12:26       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 64742-88-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 09/25/02       
EXPERIMENT: 96001 TEST: 06                                                                                     TIME: 11:12:26       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 64742-88-7      
                                                                                                                                   
                            STODDARD SOLVENT (TYPE IIC)                                                                             
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = CONTROL                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      458   499   525   534   540   600   603   617   628   632                 |                                                 
 |      644   651   681   687   694   710                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 550     MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      398   403   517   534   566   576   582   618   646   659                 |                                                 
 |      673   673   675   676   683   695   695   723                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 1100    MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 1    TERMINAL 27        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      400   470   478   484   509   527   527   617   628   644                 |                                                 
 |      650   653   667   681   698   702   702   703   707   709                 |                                                 
 |      709   723                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      75                                                                        |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                            STODDARD SOLVENT (TYPE IIC)                                                                             
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 2200    MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      365   506   521   550   557   563   575   593   593   593                 |                                                 
 |      626   645   653   655   669   681   710   728                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                            STODDARD SOLVENT (TYPE IIC)                                                                             
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  98.0  90.0  86.0  76.0  68.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |550        |   100.0 100.0 100.0 100.0  96.0  96.0  92.0  86.0  80.0  64.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1100       |   100.0 100.0 100.0 100.0  98.0  91.8  85.7  85.7  75.5  55.1      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |2200       |   100.0 100.0 100.0  98.0  98.0  98.0  94.0  80.0  72.0  64.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                CONTROL      550          1100         2200     |                                                 
 |                                             MG/M3        MG/M3        MG/M3    |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       68.0%        64.0%        55.1%        64.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.690      P=0.860      P=0.320      P=0.791  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       606.4        610.7        617.6        599.1    |                                                 
 |NATURAL DEATHS (C)      |       (18.8)       (22.8)       (21.2)       (20.2)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       689.8        686.4        666.9        682.2    |                                                 
 |(STANDARD ERROR)        |       (10.1)       (11.4)       (17.1)       (11.4)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                            STODDARD SOLVENT (TYPE IIC)                                                                             
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 730 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = CONTROL                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      424   492   530   590   594   618   649   668   681   683                 |                                                 
 |      694   702   708   727                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 550     MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      366   455   470   557   578   586   597   620   637   653                 |                                                 
 |      653   666   675   677   688   695                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 1100    MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      15    506   535   557   563   590   600   634   639   652                 |                                                 
 |      655   659   664   673   675   695   703   703   704   705                 |                                                 
 |      708   714   723                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                            STODDARD SOLVENT (TYPE IIC)                                                                             
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 730 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 2200    MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      282   408   465   503   554   634   639   672   694   695                 |                                                 
 |      705   707   708   709   724   725                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                            STODDARD SOLVENT (TYPE IIC)                                                                             
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 730 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |CONTROL    |   100.0 100.0 100.0 100.0  98.0  98.0  94.0  90.0  86.0  72.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |550        |   100.0 100.0 100.0 100.0  98.0  94.0  94.0  86.0  78.0  68.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1100       |    98.0  98.0  98.0  98.0  98.0  98.0  94.0  86.0  74.0  54.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |2200       |   100.0 100.0 100.0  98.0  96.0  94.0  92.0  90.0  86.0  68.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                CONTROL      550          1100         2200     |                                                 
 |                                             MG/M3        MG/M3        MG/M3    |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       72.0%        68.0%        54.0%        68.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.757      P=0.715      P=0.104      P=0.845  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       625.7        598.3        620.5        614.0    |                                                 
 |NATURAL DEATHS (C)      |       (24.2)       (23.7)       (30.4)       (33.4)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       700.8        687.9        679.6        692.9    |                                                 
 |(STANDARD ERROR)        |       ( 9.4)       (11.5)       (15.9)       (13.0)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                                    STODDARD SOLVENT (TYPE IIC)                                                     
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        CONTROL          = 1                                                        
                                                        550     MG/M3    = 2                                                        
                                                        1100    MG/M3    = 3                                                        
                                                        2200    MG/M3    = 4                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 1                                                         4    23        1                                                  
      |                                                                                                                             
      |                                                           4    22        1 3   14                                           
      |                                                                 2          33  142 1                                        
   95 +                                                                                                                             
      |                                                                             33   2 1 1 4                                    
      |                                                                                      11442                                  
      |                                                                              3  3                                           
   90 +                                                                                 3   3 1 42 2   1                            
      |                                                                                                                             
P     |                                                                                          4 22  11                           
E     |                                                                                     3      42 4 1 1                         
R  85 +                                                                                                                             
C     |                                                                                                   11  2                     
E     |                                                                                                    11 2  2                  
N     |                                                                                                    3 3                      
T  80 +                                                                                               4    4113  2 2                
      |                                                                                                                             
S     |                                                                                                    4 113                    
U     |                                                                                                       14    1               
R  75 +                                                                                                        3  3                 
V     |                                                                                                           3 11              
I     |                                                                                                        4  42211             
V     |                                                                                                             3 3             
A  70 +                                                                                                           4 2 131           
L     |                                                                                                                             
      |                                                                                                             4   1   1       
      |                                                                                                               2 4 2         
   65 +                                                                                                                             
      |                                                                                                                   2 2       
      |                                                                                                                             
      |                                                                                                                33           
   60 +                                                                                                                             
      |                                                                                                                             
      |                                                                                                                 3 3         
      |                                                                                                                             
   55 +                                                                                                                   3 3       
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 27 obs hidden.                                                                                                                
                                                                                                                                   
                                                    STODDARD SOLVENT (TYPE IIC)                                                     
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        CONTROL          = 1                                                        
                                                        550     MG/M3    = 2                                                        
                                                        1100    MG/M3    = 3                                                        
                                                        2200    MG/M3    = 4                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
  100 + 1  3                                         4            2        1                                                        
      |                                                                                                                             
      |    3                                         4            2      4 1    2     1 3                                           
      |                                                                  4      2 42  1 3   13                                      
   95 +                                                                                                                             
      |                                                                           42   4    13  2     1                             
      |                                                                                4        23 2                                
      |                                                                                                                             
   90 +                                                                                         43 22 1   1 4                       
      |                                                                                                                             
      |                                                                                             2 32  1 441                     
      |                                                                                                2  2 341   1                 
P  85 +                                                                                                                             
E     |                                                                                                   2 23    1 1 4             
R     |                                                                                                     23 2                    
C     |                                                                                                                             
E  80 +                                                                                                             1 14            
N     |                                                                                                                             
T     |                                                                                                        2 32   11            
      |                                                                                                           22   11           
S  75 +                                                                                                                             
U     |                                                                                                          3 3    1 1         
R     |                                                                                                            2 2  4 1 1       
V     |                                                                                                                             
I  70 +                                                                                                            3 22             
V     |                                                                                                                             
A     |                                                                                                               23  4 2       
L     |                                                                                                                             
   65 +                                                                                                                             
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                                             
   60 +                                                                                                                33           
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                                 3 3         
   55 +                                                                                                                             
      |                                                                                                                   3 3       
      |                                                                                                                             
      |                                                                                                                             
   50 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 21 obs hidden.                                                                                                                
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.