National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4875

TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02
Route: GAVAGE                                                                                                     Time: 15:22:24

                                                          31 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/24/98 - 09/25/98

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    10 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           48           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 16           16           15           16           16           16           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10            9           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (9)          (10)         (10)         (10)         
      Basophilic Focus                                                                        1 (10%)                               
      Cholangiofibrosis                                                                                                 1 (10%)     
      Clear Cell Focus                                              1 (10%)                                             1 (10%)     
      Degeneration, Cystic                                          1 (10%)                                                         
      Inflammation                                     7 (70%)     10 (100%)     9 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Mixed Cell Focus                                              2 (20%)      2 (22%)      3 (30%)      1 (10%)      1 (10%)     
      Mixed Cell Focus, Multiple                                                                           2 (20%)      1 (10%)     
      Necrosis                                                                                1 (10%)                               
      Pigmentation                                                                            3 (30%)      5 (50%)      8 (80%)     
      Hepatocyte, Hypertrophy                                       3 (30%)      4 (44%)      6 (60%)      6 (60%)      8 (80%)     
   Pancreas                                           (10)         (10)         (9)          (10)         (10)         (10)         
      Basophilic Focus                                                                                                  1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (9)          (10)         (10)         (10)         
      Angiectasis                                                   1 (10%)                                                         
      Degeneration, Cystic                                                                                 1 (10%)                  
      Hyperplasia                                                                1 (11%)      1 (10%)                               
      Hypertrophy                                      2 (20%)      3 (30%)      2 (22%)      3 (30%)      2 (20%)      4 (40%)     
   Adrenal Medulla                                    (10)                                                                          
      Hyperplasia                                      1 (10%)                                                                      
   Thyroid Gland                                      (10)         (3)          (3)          (5)          (6)          (5)          
      Follicular Cell, Hypertrophy                                  3 (100%)     3 (100%)     5 (100%)     6 (100%)     5 (100%)    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (9)          (10)         (10)         (10)         
      Atrophy                                          8 (80%)      8 (80%)      4 (44%)     10 (100%)     9 (90%)     10 (100%)    
   Uterus                                             (10)                                   (1)          (1)                       
      Inflammation, Suppurative                        1 (10%)                                             1 (100%)                 
      Metaplasia, Squamous                             5 (50%)                                             1 (100%)                 
      Endometrium, Hyperplasia, Cystic                 1 (10%)                                1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                                          
      Pigmentation                                    10 (100%)                                                                     
   Thymus                                             (10)         (10)         (9)          (10)         (10)         (10)         
      Atrophy                                          2 (20%)      3 (30%)      1 (11%)      3 (30%)      3 (30%)      3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (9)          (10)         (10)         (10)         
      Infiltration Cellular, Histiocyte                2 (20%)      3 (30%)      2 (22%)      3 (30%)      1 (10%)      1 (10%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Metaplasia, Bronchiolar                                                                      1 (10%)     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98                                                               
                                                                                                                                    
  Scheduled Sacrifice                                 16           16                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)                                                             
      Cholangiofibrosis                                1 (10%)                                                                      
      Fatty Change, Diffuse                                         1 (10%)                                                         
      Hepatocyte, Multinucleate                        2 (20%)      8 (80%)                                                         
      Inflammation                                    10 (100%)    10 (100%)                                                        
      Mixed Cell Focus                                 2 (20%)      2 (20%)                                                         
      Mixed Cell Focus, Multiple                       1 (10%)      4 (40%)                                                         
      Necrosis                                         1 (10%)      2 (20%)                                                         
      Pigmentation                                     8 (80%)     10 (100%)                                                        
      Toxic Hepatopathy                                            10 (100%)                                                        
      Hepatocyte, Hypertrophy                         10 (100%)    10 (100%)                                                        
   Pancreas                                           (10)         (10)                                                             
      Inflammation, Chronic Active                                  1 (10%)                                                         
      Acinus, Atrophy                                               1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)                                                             
      Hyperplasia                                                   1 (10%)                                                         
      Hypertrophy                                                   4 (40%)                                                         
   Thyroid Gland                                      (5)          (10)                                                             
      Follicular Cell, Hypertrophy                     5 (100%)     7 (70%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)                                                             
      Atrophy                                          7 (70%)      4 (40%)                                                         
   Uterus                                                          (10)                                                             
      Inflammation, Suppurative                                     1 (10%)                                                         
      Metaplasia, Squamous                                          4 (40%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (1)          (10)                                                             
      Hematopoietic Cell Proliferation                 1 (100%)                                                                     
      Pigmentation                                                 10 (100%)                                                        
   Thymus                                             (10)         (10)                                                             
      Atrophy                                          8 (80%)     10 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)                                                             
      Infiltration Cellular, Histiocyte                1 (10%)      4 (40%)                                                         
      Alveolar Epithelium, Metaplasia, Bronchiolar                  2 (20%)                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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