Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/4875

TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02
Route: GAVAGE                                                                                                     Time: 15:22:24

                                                          31 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/24/98 - 09/25/98

       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    10 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           48           98           98           98           98           
                                                                                                                                    
  Scheduled Sacrifice                                 16           16           15           16           16           16           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10            9           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (9)          (10)         (10)         (10)         
      Basophilic Focus                                                                        1 (10%)                               
      Cholangiofibrosis                                                                                                 1 (10%)     
      Clear Cell Focus                                              1 (10%)                                             1 (10%)     
      Degeneration, Cystic                                          1 (10%)                                                         
      Inflammation                                     7 (70%)     10 (100%)     9 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Mixed Cell Focus                                              2 (20%)      2 (22%)      3 (30%)      1 (10%)      1 (10%)     
      Mixed Cell Focus, Multiple                                                                           2 (20%)      1 (10%)     
      Necrosis                                                                                1 (10%)                               
      Pigmentation                                                                            3 (30%)      5 (50%)      8 (80%)     
      Hepatocyte, Hypertrophy                                       3 (30%)      4 (44%)      6 (60%)      6 (60%)      8 (80%)     
   Pancreas                                           (10)         (10)         (9)          (10)         (10)         (10)         
      Basophilic Focus                                                                                                  1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (9)          (10)         (10)         (10)         
      Angiectasis                                                   1 (10%)                                                         
      Degeneration, Cystic                                                                                 1 (10%)                  
      Hyperplasia                                                                1 (11%)      1 (10%)                               
      Hypertrophy                                      2 (20%)      3 (30%)      2 (22%)      3 (30%)      2 (20%)      4 (40%)     
   Adrenal Medulla                                    (10)                                                                          
      Hyperplasia                                      1 (10%)                                                                      
   Thyroid Gland                                      (10)         (3)          (3)          (5)          (6)          (5)          
      Follicular Cell, Hypertrophy                                  3 (100%)     3 (100%)     5 (100%)     6 (100%)     5 (100%)    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (9)          (10)         (10)         (10)         
      Atrophy                                          8 (80%)      8 (80%)      4 (44%)     10 (100%)     9 (90%)     10 (100%)    
   Uterus                                             (10)                                   (1)          (1)                       
      Inflammation, Suppurative                        1 (10%)                                             1 (100%)                 
      Metaplasia, Squamous                             5 (50%)                                             1 (100%)                 
      Endometrium, Hyperplasia, Cystic                 1 (10%)                                1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                                          
      Pigmentation                                    10 (100%)                                                                     
   Thymus                                             (10)         (10)         (9)          (10)         (10)         (10)         
      Atrophy                                          2 (20%)      3 (30%)      1 (11%)      3 (30%)      3 (30%)      3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (9)          (10)         (10)         (10)         
      Infiltration Cellular, Histiocyte                2 (20%)      3 (30%)      2 (22%)      3 (30%)      1 (10%)      1 (10%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      10 NG/KG     30 NG/KG     100          175          300             
                                                                                          NG/KG        NG/KG        NG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Metaplasia, Bronchiolar                                                                      1 (10%)     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           98                                                               
                                                                                                                                    
  Scheduled Sacrifice                                 16           16                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)                                                             
      Cholangiofibrosis                                1 (10%)                                                                      
      Fatty Change, Diffuse                                         1 (10%)                                                         
      Hepatocyte, Multinucleate                        2 (20%)      8 (80%)                                                         
      Inflammation                                    10 (100%)    10 (100%)                                                        
      Mixed Cell Focus                                 2 (20%)      2 (20%)                                                         
      Mixed Cell Focus, Multiple                       1 (10%)      4 (40%)                                                         
      Necrosis                                         1 (10%)      2 (20%)                                                         
      Pigmentation                                     8 (80%)     10 (100%)                                                        
      Toxic Hepatopathy                                            10 (100%)                                                        
      Hepatocyte, Hypertrophy                         10 (100%)    10 (100%)                                                        
   Pancreas                                           (10)         (10)                                                             
      Inflammation, Chronic Active                                  1 (10%)                                                         
      Acinus, Atrophy                                               1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)                                                             
      Hyperplasia                                                   1 (10%)                                                         
      Hypertrophy                                                   4 (40%)                                                         
   Thyroid Gland                                      (5)          (10)                                                             
      Follicular Cell, Hypertrophy                     5 (100%)     7 (70%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)                                                             
      Atrophy                                          7 (70%)      4 (40%)                                                         
   Uterus                                                          (10)                                                             
      Inflammation, Suppurative                                     1 (10%)                                                         
      Metaplasia, Squamous                                          4 (40%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (1)          (10)                                                             
      Hematopoietic Cell Proliferation                 1 (100%)                                                                     
      Pigmentation                                                 10 (100%)                                                        
   Thymus                                             (10)         (10)                                                             
      Atrophy                                          8 (80%)     10 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)                                                             
      Infiltration Cellular, Histiocyte                1 (10%)      4 (40%)                                                         
      Alveolar Epithelium, Metaplasia, Bronchiolar                  2 (20%)                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96007-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/14/02    
Route: GAVAGE                                                                                                     Time: 15:22:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                550          1000                                                                
                                                   NG/KG        NG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------