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TDMS Study 96010-03 Pathology Tables

NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14

                                                          FINAL#1/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  7775-09-9

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            3            6            5                                     
    Moribund Sacrifice                                10           11           11            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           34           32           40                                     
    Natural Death                                                                1            1                                     
    Moribund Sacrifice                                              2                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (49)         (45)         (49)                                   
      Amyloid Deposition                                            1 [2.0]                                                         
      Epithelium, Cyst                                                                        1 [1.0]                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                                         2 [2.0]                                            
      Basophilic Focus                                42           44           41           42                                     
      Cholangiofibrosis                                1 [4.0]                   1 [4.0]      3 [4.0]                               
      Clear Cell Focus                                 6           16           18           10                                     
      Congestion                                       6 [2.0]      2 [3.0]      2 [2.5]      1 [2.0]                               
      Degeneration, Cystic, Focal                      1 [2.0]                   1 [2.0]      3 [2.0]                               
      Eosinophilic Focus                                            1            1            2                                     
      Fibrosis, Focal                                                                         1 [1.0]                               
      Hemorrhage                                       1 [2.0]                                                                      
      Hepatodiaphragmatic Nodule                       7            4            8            3                                     
      Hyperplasia, Focal, Histiocytic                 20 [1.6]     19 [1.7]     16 [1.6]     23 [1.8]                               
      Hyperplasia, Focal, Regenerative                 1 [1.0]                                1 [3.0]                               
      Hyperplasia, Regenerative                                                               2 [4.0]                               
      Infarct, Multiple                                             1 [3.0]                                                         
      Infiltration Cellular, Focal,                                                                                                 
        Polymorphonuclear                                                        1 [2.0]                                            
      Infiltration Cellular, Polymorphonuclear                      1 [3.0]                                                         
      Infiltration Cellular, Mixed Cell               39 [1.9]     38 [1.9]     35 [1.9]     41 [2.0]                               
      Mixed Cell Focus                                12            6            7            8                                     
      Thrombosis                                                    1 [3.0]                                                         
      Bile Duct, Cyst                                               1 [2.0]                                                         
      Bile Duct, Hyperplasia                          29 [1.5]     24 [1.5]     34 [1.7]     26 [2.0]                               
      Capsule, Cyst                                    1 [3.0]                                                                      
      Hepatocyte, Karyomegaly                                       1 [3.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Necrosis, Focal                                   2 [1.5]                   1 [2.0]                               
      Hepatocyte, Vacuolization Cytoplasmic                                      2 [2.0]                                            
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
        Diffuse                                        1 [2.0]      2 [2.5]      1 [2.0]      2 [3.0]                               
      Hepatocyte, Vacuolization Cytoplasmic, Focal    17 [1.5]     10 [1.7]     10 [1.8]     10 [1.4]                               
      Hepatocyte, Periportal, Vacuolization                                                                                         
        Cytoplasmic                                                 2 [2.0]                                                         
      Hepatocyte, Periportal, Centrilobular,                                                                                        
        Vacuolization Cytoplasmic                                                1 [2.0]                                            
      Hepatocyte, Centrilobular, Necrosis              2 [2.0]      1 [4.0]      1 [3.0]      2 [2.5]                               
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                    5 [3.0]      3 [3.0]      8 [3.4]      3 [2.3]                               
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic                                                 2 [3.5]                                                         
   Mesentery                                          (18)         (10)         (13)         (16)                                   
      Inflammation, Chronic, Focal                                  1 [2.0]                                                         
      Fat, Necrosis                                    4 [2.5]      2 [2.0]      1 [3.0]                                            
      Fat, Necrosis, Focal                            12 [2.3]      5 [2.6]      9 [2.8]     13 [2.6]                               
   Pancreas                                           (50)         (49)         (49)         (49)                                   
      Lipomatosis                                                                             1 [1.0]                               
      Acinus, Atrophy, Diffuse                                                                1 [4.0]                               
      Acinus, Atrophy, Focal                          15 [1.4]      8 [2.1]      9 [1.6]     16 [1.4]                               
      Duct, Cyst, Focal                                1 [1.0]      2 [1.0]      4 [1.0]      1 [2.0]                               
      Duct, Cyst, Focal, Multiple                     10 [1.4]     14 [1.8]     11 [1.5]     18 [1.6]                               
      Duct, Hyperplasia, Focal                                                                1 [1.0]                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy, Focal                                   2 [2.0]                                                                      
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                                         1 [3.0]      1 [3.0]      1 [2.0]                               
      Erosion                                                       1 [2.0]                                                         
      Inflammation, Chronic                                         2 [2.5]      1 [3.0]                                            
      Inflammation, Chronic, Focal                                               1 [2.0]                                            
      Perforation                                                                1 [3.0]                                            
      Ulcer                                            2 [2.0]      7 [2.4]                   1 [2.0]                               
      Epithelium, Hyperplasia                          2 [2.0]      4 [2.3]      6 [2.5]      1 [2.0]                               
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Erosion                                          2 [2.0]                   2 [1.5]      2 [1.5]                               
      Erosion, Focal                                   1 [2.0]                                                                      
      Inflammation, Chronic                                         1 [2.0]                                                         
      Necrosis, Focal                                               1 [2.0]                                                         
      Pigmentation, Focal                              1 [2.0]                                                                      
      Ulcer                                                         1 [2.0]                                                         
   Tooth                                                           (2)          (2)          (1)                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Malformation                                                               1                                                  
      Dentine, Malformation                                         1 [3.0]                                                         
      Peridontal Tissue, Inflammation, Chronic                      1 [3.0]      2 [3.0]                                            
      Peridontal Tissue, Inflammation, Chronic,                                                                                     
         Focal                                                                                1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                       (1)                                    
      Thrombosis                                                    1 [3.0]                                                         
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   4 [1.5]      2 [2.5]                   2 [2.0]                               
      Infiltration Cellular, Mixed Cell                             1 [1.0]      1 [2.0]      4 [1.5]                               
      Thrombosis                                       1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                2 [1.0]      3 [1.3]      5 [1.0]      2 [1.0]                               
      Angiectasis                                      2 [2.5]      1 [3.0]      1 [2.0]      2 [3.0]                               
      Cytoplasmic Alteration, Focal                    1 [2.0]      2 [2.0]      3 [2.0]      2 [1.5]                               
      Degeneration, Cystic, Focal                                   1 [3.0]                   1 [2.0]                               
      Fibrosis, Focal                                                            1 [2.0]                                            
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Hemorrhage                                       1 [3.0]      1 [3.0]                   2 [2.5]                               
      Infiltration Cellular, Mixed Cell                             1 [2.0]                                                         
      Necrosis, Focal                                               1 [3.0]                                                         
      Vacuolization Cytoplasmic, Focal                 7 [1.4]     13 [1.6]      7 [1.9]      8 [1.8]                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                             1 [3.0]                               
      Hyperplasia, Focal                               3 [1.0]      4 [1.3]      1 [1.0]      1 [1.0]                               
      Infiltration Cellular, Focal, Lymphoid                                                  1 [2.0]                               
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Hyperplasia, Focal                                                         1 [2.0]                                            
   Parathyroid Gland                                  (47)         (47)         (48)         (47)                                   
      Hyperplasia, Focal                                                         1 [3.0]                                            
   Pituitary Gland                                    (49)         (49)         (50)         (50)                                   
      Angiectasis                                     10 [2.5]      6 [2.8]      2 [3.5]     13 [2.6]                               
      Pigmentation, Focal                              1 [2.0]                                                                      
      Pars Distalis, Angiectasis                       1 [3.0]      2 [2.5]      2 [3.5]                                            
      Pars Distalis, Cyst                              2 [2.5]      2 [2.5]      1 [3.0]      2 [1.5]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cytoplasmic Alteration, Focal     3 [1.0]      1 [1.0]      2 [1.0]      3 [1.7]                               
      Pars Distalis, Degeneration, Cystic, Focal      11 [1.9]     14 [1.8]     11 [2.4]      3 [2.0]                               
      Pars Distalis, Hemorrhage, Focal                 9 [2.9]      6 [2.8]     10 [2.5]      2 [3.0]                               
      Pars Distalis, Hyperplasia, Focal                7 [2.3]      5 [2.4]     10 [2.8]      4 [1.8]                               
      Pars Distalis, Infiltration Cellular, Focal                                1 [2.0]                                            
      Pars Nervosa, Hyperplasia, Atypical, Focal                    1 [3.0]                                                         
      Rathke's Cleft, Cyst                             1 [2.0]      2 [2.5]                                                         
      Rathke's Cleft, Hemorrhage                       1 [2.0]      2 [2.5]      2 [2.5]      6 [2.8]                               
      Rathke's Cleft, Hyperplasia, Cystic                                        1 [3.0]                                            
   Thyroid Gland                                      (47)         (47)         (43)         (46)                                   
      Congestion                                                                              1 [1.0]                               
      Ultimobranchial Cyst                             1 [2.0]                   1 [1.0]                                            
      C-Cell, Hyperplasia                             43 [2.2]     45 [2.1]     43 [2.5]     44 [2.3]                               
      Follicle, Mineralization, Focal                 25 [1.0]     26 [1.0]     40 [1.3]     44 [2.1]                               
      Follicular Cell, Hyperplasia, Cystic, Focal      1 [2.0]                                                                      
      Follicular Cell, Hypertrophy                     3 [1.3]      7 [1.0]     27 [1.2]     42 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (4)          (6)                                    
      Mediastinum, Cyst                                                          1 [3.0]                                            
      Mediastinum, Thrombosis                                                                 1 [3.0]                               
      Oral, Foreign Body, Focal                                                               1 [3.0]                               
      Oral, Necrosis, Focal                                                                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (49)                                   
      Cyst                                             1 [4.0]                                                                      
      Degeneration, Cystic                             5 [3.0]      2 [3.0]      6 [2.8]      1 [3.0]                               
      Hyperplasia                                                                             1 [3.0]                               
      Hyperplasia, Cystic                              1 [3.0]      4 [2.5]      3 [2.3]      1 [3.0]                               
      Hyperplasia, Cystic, Focal                                    1 [2.0]                                                         
      Inflammation, Chronic                            6 [2.8]      2 [1.5]      1 [3.0]      3 [2.3]                               
      Duct, Inflammation, Chronic                      1 [4.0]                                                                      
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Cyst                                             5 [2.2]      1 [3.0]      1 [3.0]      4 [1.8]                               
      Corpus Luteum, Hyperplasia                                                              1 [3.0]                               
      Interstitial Cell, Hyperplasia                                1 [2.0]      1 [3.0]                                            
      Periovarian Tissue, Cyst                         4 [3.0]      4 [3.0]      2 [3.5]      1 [3.0]                               
   Uterus                                             (50)         (50)         (49)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                    1 [3.0]                   1 [3.0]                               
      Hydrometra                                       1 [3.0]                                                                      
      Inflammation, Chronic                                                      1 [3.0]                                            
      Inflammation, Focal, Suppurative                                                        1 [3.0]                               
      Inflammation, Suppurative                                     1 [3.0]                   1 [3.0]                               
      Ulcer, Chronic Active                                                                   1 [4.0]                               
      Endometrium, Hyperplasia, Cystic                16 [1.8]      7 [1.4]     16 [1.9]     11 [1.8]                               
   Vagina                                             (6)          (3)          (3)          (1)                                    
      Cyst                                             2 [3.0]      1 [3.0]      1 [3.0]      1 [3.0]                               
      Inflammation, Chronic                            1 [3.0]                                                                      
      Inflammation, Suppurative                                     1 [3.0]      1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Angiectasis                                                                1 [3.0]                                            
      Hemorrhage                                                                              1 [2.0]                               
      Hyperplasia                                      2 [3.5]      1 [1.0]      1 [2.0]                                            
      Hyperplasia, Focal, Histiocytic                                            2 [3.0]      2 [4.0]                               
      Myeloid Cell, Hyperplasia                        7 [2.4]      3 [2.7]      2 [2.5]      6 [2.7]                               
      Myeloid Cell, Erythroid Cell, Hyperplasia                     2 [3.0]      2 [3.0]      3 [3.0]                               
   Lymph Node                                         (36)         (34)         (30)         (39)                                   
      Hyperplasia, Plasma Cell                         1 [3.0]                                                                      
      Pigmentation                                                                            1 [3.0]                               
      Deep Cervical, Hemorrhage                        1 [2.0]                                                                      
      Deep Cervical, Hyperplasia, Lymphoid             1 [3.0]                                                                      
      Deep Cervical, Hyperplasia, Plasma Cell                                                 1 [3.0]                               
      Mediastinal, Angiectasis                                                   1 [3.0]                                            
      Mediastinal, Congestion                          1 [3.0]                                                                      
      Mediastinal, Ectasia                             2 [3.0]      4 [3.0]      2 [3.0]      4 [3.0]                               
      Mediastinal, Hemorrhage                          6 [3.0]      6 [3.0]      5 [3.0]      3 [2.7]                               
      Mediastinal, Hyperplasia, Histiocytic            1 [3.0]      4 [3.0]      2 [3.0]      3 [3.0]                               
      Mediastinal, Hyperplasia, Lymphoid               1 [3.0]      2 [2.5]      2 [3.0]      3 [3.0]                               
      Mediastinal, Hyperplasia, Plasma Cell                         1 [3.0]                                                         
      Mediastinal, Infiltration Cellular, Mixed                                                                                     
        Cell                                                                     1 [3.0]                                            
      Mediastinal, Pigmentation                                                  1 [3.0]                                            
      Pancreatic, Angiectasis                                       1 [3.0]                                                         
      Pancreatic, Ectasia                              1 [2.0]                                1 [3.0]                               
      Pancreatic, Hemorrhage                           5 [3.0]      3 [3.0]                   5 [2.6]                               
      Pancreatic, Hyperplasia, Histiocytic            31 [1.8]     22 [2.2]     15 [2.5]     25 [2.4]                               
      Pancreatic, Hyperplasia, Lymphoid                                          1 [1.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Pigmentation                         1 [2.0]      7 [1.6]      3 [2.0]      6 [1.7]                               
   Lymph Node, Mandibular                             (4)          (6)          (4)          (5)                                    
      Ectasia                                                       1 [3.0]                                                         
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)                                   
      Hemorrhage                                                                              1 [3.0]                               
      Hyperplasia, Focal, Histiocytic                                            1 [3.0]                                            
      Hyperplasia, Histiocytic                         2 [3.0]      4 [3.0]                   4 [3.3]                               
      Hyperplasia, Lymphoid                            1 [3.0]                                                                      
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                                            1 [3.0]                   1 [3.0]                               
      Fibrosis, Focal                                               1 [3.0]                   1 [3.0]                               
      Hematopoietic Cell Proliferation                16 [2.4]     21 [2.4]      8 [2.4]     17 [2.4]                               
      Hemorrhage                                       1 [2.0]      1 [2.0]      1 [3.0]      2 [2.5]                               
      Hyperplasia, Focal, Histiocytic                  2 [4.0]      4 [2.8]      2 [3.5]      5 [3.6]                               
      Infarct                                                                                 1 [3.0]                               
      Pigmentation, Focal                                                        1 [3.0]                                            
      Red Pulp, Fibrosis, Diffuse                                                             1 [3.0]                               
   Thymus                                             (49)         (48)         (48)         (48)                                   
      Angiectasis                                      2 [2.5]      1 [2.0]                                                         
      Cyst                                                          1 [2.0]                                                         
      Hemorrhage                                       1 [3.0]                   2 [2.0]      1 [3.0]                               
      Hyperplasia, Lymphoid                            1 [2.0]                                1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Dilatation                                      37 [3.1]     39 [3.1]     34 [3.0]     38 [3.1]                               
      Ectasia                                          4 [2.8]      1 [2.0]      3 [2.7]      2 [2.5]                               
      Fibrosis                                         2 [2.5]      1 [3.0]      1 [2.0]      4 [2.8]                               
      Fibrosis, Focal                                  1 [2.0]                                                                      
      Hyperplasia                                      7 [2.4]     11 [2.2]     10 [2.4]      9 [2.3]                               
      Hyperplasia, Focal                               1 [3.0]                                1 [4.0]                               
      Inflammation, Chronic                                                                   1 [2.0]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic, Focal                                  1 [1.0]                                                         
      Ulcer                                                                                   1 [1.0]                               
      Subcutaneous Tissue, Fibrosis, Focal             1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Compression, Focal                               9 [2.7]      9 [2.9]     10 [2.9]      9 [3.0]                               
      Hemorrhage, Focal                                             4 [2.3]      3 [1.7]      2 [1.5]                               
      Necrosis, Focal                                               1 [3.0]                                                         
      Thalamus, Mineralization, Focal                  1 [3.0]                                                                      
      Thalamus, Necrosis, Focal                        1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                                 2 [3.0]      1 [3.0]                               
      Hemorrhage, Focal                                1 [2.0]                   1 [3.0]      2 [3.0]                               
      Hyperplasia, Focal, Histiocytic                  1 [2.0]      1 [2.0]                   2 [3.0]                               
      Hyperplasia, Histiocytic                         4 [1.8]      6 [1.3]      5 [1.6]      2 [1.0]                               
      Infiltration Cellular, Polymorphonuclear                      1 [3.0]                                                         
      Infiltration Cellular, Mixed Cell                2 [2.5]      3 [2.0]      2 [2.0]      1 [3.0]                               
      Inflammation, Chronic, Focal                     2 [1.0]                   4 [1.5]      2 [1.0]                               
      Metaplasia, Focal, Osseous                                                 1 [2.0]                                            
      Alveolar Epithelium, Hyperplasia                 1 [1.0]                                                                      
      Alveolar Epithelium, Hyperplasia, Focal          4 [1.5]      2 [1.5]      3 [2.0]      2 [1.5]                               
      Interstitium, Edema                                                                     1 [3.0]                               
      Mediastinum, Edema                                                         1 [3.0]                                            
      Peribronchiolar, Hyperplasia, Lymphoid                                     1 [2.0]                                            
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 [2.0]      2 [2.0]                                                         
      Nasolacrimal Duct, Inflammation                               1 [2.0]                   1 [3.0]                               
      Respiratory Epithelium, Metaplasia, Focal,                                                                                    
         Squamous                                                                             1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (49)         (47)         (50)                                   
      Atrophy                                          1 [3.0]                                                                      
      Cataract                                         2 [2.5]      3 [2.3]      1 [3.0]      2 [3.0]                               
      Hemorrhage                                                    1 [3.0]                                                         
      Retinal Detachment                               1 [3.0]                                                                      
      Bilateral, Atrophy                                                                      1 [4.0]                               
      Cornea, Inflammation, Chronic                    1 [4.0]      1 [3.0]                                                         
      Cornea, Necrosis, Focal                          1 [4.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Retina, Degeneration                             1 [4.0]      2 [3.0]      1 [3.0]      2 [2.5]                               
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Cystic, Focal                       1 [2.0]                                                                      
      Hyperplasia, Focal                                                                      1 [1.0]                               
      Hyperplasia, Focal, Histiocytic                  2 [2.5]                   1 [1.0]                                            
      Inflammation, Chronic, Focal                                  1 [3.0]      1 [1.0]      2 [1.0]                               
      Metaplasia, Focal, Squamous                                                1 [3.0]                                            
      Epithelium, Hyperplasia, Focal                   1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (47)         (47)                                   
      Atrophy, Diffuse                                              1 [4.0]                                                         
      Atrophy, Focal                                   1 [3.0]                                2 [3.0]                               
      Cyst                                                                       1 [2.0]      1 [2.0]                               
      Hyperplasia, Lymphoid                                                      1 [2.0]                                            
      Infarct                                                       1 [3.0]      1 [3.0]                                            
      Infiltration Cellular, Polymorphonuclear                      1 [3.0]                                                         
      Inflammation, Chronic                            1 [2.0]      2 [2.0]                                                         
      Inflammation, Chronic, Focal, Granulomatous                                             1 [3.0]                               
      Nephropathy                                     43 [1.1]     41 [1.2]     37 [1.1]     38 [1.3]                               
      Pelvis, Inflammation, Chronic                                 1 [3.0]                                                         
      Pelvis, Transitional Epithelium, Hyperplasia                  1 [2.0]                                                         
      Renal Tubule, Accumulation, Hyaline Droplet      5 [2.6]     12 [2.0]     11 [2.2]      5 [2.0]                               
      Renal Tubule, Pigmentation                       2 [1.0]      1 [2.0]      4 [1.8]      4 [2.3]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           13           11           14                                     
    Natural Death                                      3           10            8            8                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           27           31           28                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (44)         (49)                                   
      Edema                                                                                   2 [3.0]                               
   Intestine Large, Rectum                            (48)         (47)         (47)         (50)                                   
      Congestion                                                                              1 [3.0]                               
      Edema                                                                                   1 [3.0]                               
      Hemorrhage                                                                              1 [3.0]                               
   Intestine Large, Cecum                             (47)         (46)         (43)         (47)                                   
      Edema                                                         1 [3.0]                   1 [3.0]                               
      Ulcer                                                                                   1 [4.0]                               
   Intestine Small, Duodenum                          (49)         (46)         (46)         (47)                                   
      Ulcer                                                         1 [3.0]                                                         
      Epithelium, Hyperplasia                                                                 1 [3.0]                               
   Intestine Small, Jejunum                           (47)         (46)         (42)         (44)                                   
      Epithelium, Necrosis                                                       1 [2.0]                                            
   Intestine Small, Ileum                             (47)         (46)         (42)         (47)                                   
      Ulcer                                            1 [4.0]                                                                      
   Liver                                              (50)         (50)         (48)         (50)                                   
      Angiectasis, Focal                               2 [1.5]      1 [2.0]      1 [2.0]      3 [2.0]                               
      Basophilic Focus                                27           30           33           29                                     
      Cholangiofibrosis                                2 [3.0]      1 [1.0]      1 [4.0]      1 [2.0]                               
      Clear Cell Focus                                21           18           29           15                                     
      Congestion                                                    2 [3.0]                                                         
      Degeneration, Cystic, Focal                     13 [1.4]      9 [1.7]     12 [2.0]     14 [1.9]                               
      Eosinophilic Focus                               2            3                         2                                     
      Fibrosis, Focal                                               1 [3.0]                   1 [2.0]                               
      Hemorrhage, Focal                                1 [3.0]                                                                      
      Hepatodiaphragmatic Nodule                       6 [2.7]      2 [3.0]      3 [3.0]      5 [3.0]                               
      Hyperplasia, Focal, Histiocytic                  6 [1.8]      2 [1.5]      8 [1.5]      5 [1.4]                               
      Hyperplasia, Focal, Lymphoid                                               1 [3.0]      1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infarct                                          1 [3.0]                                                                      
      Infiltration Cellular, Mixed Cell               36 [2.0]     29 [1.9]     33 [1.9]     28 [2.0]                               
      Mixed Cell Focus                                13           11            3            8                                     
      Bile Duct, Hyperplasia                          48 [2.8]     49 [2.9]     46 [2.8]     50 [2.9]                               
      Centrilobular, Congestion                                     1 [3.0]                                                         
      Hepatocyte, Necrosis, Focal                                   1 [2.0]                   2 [2.5]                               
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
        Diffuse                                        3 [2.3]      3 [2.7]                   4 [3.3]                               
      Hepatocyte, Vacuolization Cytoplasmic, Focal    26 [1.8]     15 [1.7]     14 [1.9]     18 [1.7]                               
      Hepatocyte, Periportal, Necrosis                              1 [3.0]                                                         
      Hepatocyte, Periportal, Vacuolization                                                                                         
        Cytoplasmic                                                 1 [2.0]      1 [2.0]                                            
      Hepatocyte, Centrilobular, Atrophy                                                      1 [3.0]                               
      Hepatocyte, Centrilobular, Necrosis              1 [4.0]      3 [2.0]      6 [2.5]      4 [2.5]                               
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                    4 [2.8]      9 [3.0]     12 [2.9]     11 [2.6]                               
      Hepatocyte, Midzonal, Necrosis                   1 [3.0]                                                                      
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic                                    6 [2.5]      1 [3.0]                   1 [3.0]                               
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic, Focal                                          1 [3.0]                                                         
      Portal, Fibrosis                                              1 [3.0]                                                         
      Portal, Hemorrhage                                            1 [3.0]                                                         
   Mesentery                                          (19)         (20)         (19)         (23)                                   
      Angiectasis                                                   1 [3.0]                                                         
      Hemorrhage                                       1 [4.0]                   1 [3.0]                                            
      Inflammation, Chronic                                                      1 [3.0]                                            
      Inflammation, Chronic, Focal                                                            1 [3.0]                               
      Fat, Necrosis                                    2 [3.0]                   2 [3.0]      2 [2.0]                               
      Fat, Necrosis, Focal                            12 [2.8]     10 [2.7]     13 [2.5]     14 [2.5]                               
   Pancreas                                           (49)         (49)         (49)         (50)                                   
      Inflammation, Chronic                            1 [3.0]                                                                      
      Acinus, Atrophy, Diffuse                                                                1 [4.0]                               
      Acinus, Atrophy, Focal                          23 [1.8]     23 [2.1]     27 [1.9]     15 [1.7]                               
      Acinus, Hyperplasia, Focal                       1 [3.0]      1 [2.0]                                                         
      Duct, Cyst, Focal                                                          1 [3.0]      1 [3.0]                               
      Duct, Cyst, Focal, Multiple                     15 [1.7]     13 [1.6]     18 [1.8]     15 [1.8]                               
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 [3.0]                               
      Hyperplasia, Focal, Histiocytic                                                         1 [3.0]                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 [3.0]      1 [3.0]                   4 [3.0]                               
      Erosion                                                                    1 [3.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                         4 [2.3]                   1 [3.0]                               
      Inflammation, Chronic, Focal                                               1 [3.0]                                            
      Inflammation, Focal                                           1 [2.0]      1 [3.0]                                            
      Ulcer                                            1 [2.0]      5 [2.4]      2 [1.5]      4 [2.8]                               
      Epithelium, Cyst                                 1 [2.0]                                                                      
      Epithelium, Hyperplasia                          2 [2.0]      8 [2.4]      1 [3.0]      7 [2.3]                               
      Epithelium, Hyperplasia, Focal                                             1 [3.0]                                            
   Stomach, Glandular                                 (49)         (48)         (48)         (50)                                   
      Erosion                                          3 [1.3]      2 [2.0]      4 [1.8]      4 [1.5]                               
      Perforation                                                                             1 [3.0]                               
      Pigmentation, Focal                                           1 [2.0]      1 [1.0]                                            
      Ulcer                                            1 [3.0]                                3 [2.7]                               
      Epithelium, Hyperplasia, Focal                                1 [2.0]                                                         
   Tongue                                             (1)          (1)          (1)          (1)                                    
      Epithelium, Hyperplasia                          1 [3.0]                                                                      
   Tooth                                                           (1)          (1)                                                 
      Malformation                                                               1 [2.0]                                            
      Peridontal Tissue, Hyperplasia, Squamous                      1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   6 [1.5]      3 [2.0]      7 [1.7]     10 [1.8]                               
      Infiltration Cellular, Mixed Cell                2 [1.5]      1 [2.0]                   2 [2.0]                               
      Inflammation, Chronic, Focal                                                            1 [3.0]                               
      Thrombosis                                       1 [3.0]      1 [4.0]      2 [3.0]      2 [3.0]                               
      Artery, Inflammation, Chronic, Focal             1 [2.0]                                                                      
      Endocardium, Valve, Inflammation, Chronic,                                                                                    
         Focal                                         1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 [1.0]      7 [1.0]      4 [1.3]      3 [1.0]                               
      Atrophy                                                                    1 [3.0]                                            
      Cytoplasmic Alteration, Focal                    3 [1.3]      3 [1.7]      2 [1.5]      4 [1.8]                               
      Degeneration, Cystic, Focal                                                2 [3.0]                                            
      Hyperplasia, Diffuse                                                       1 [3.0]                                            
      Infiltration Cellular, Mixed Cell                                                       1 [2.0]                               
      Necrosis, Focal                                                            1 [2.0]                                            
      Vacuolization Cytoplasmic, Diffuse                            1 [3.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic, Focal                12 [1.5]      8 [1.4]      7 [1.9]      6 [1.5]                               
      Capsule, Fibrosis, Focal                                      1 [2.0]                                                         
   Adrenal Medulla                                    (49)         (49)         (50)         (50)                                   
      Hyperplasia, Focal                               5 [1.6]     12 [1.4]      9 [1.6]     13 [1.8]                               
   Islets, Pancreatic                                 (50)         (49)         (49)         (50)                                   
      Hyperplasia                                                   2 [2.0]                                                         
      Hyperplasia, Focal                               1 [2.0]      1 [2.0]                                                         
   Parathyroid Gland                                  (49)         (50)         (47)         (49)                                   
      Hyperplasia, Focal                                                                      1 [2.0]                               
   Pituitary Gland                                    (48)         (50)         (49)         (50)                                   
      Angiectasis                                      2 [2.0]      4 [2.5]      1 [2.0]      3 [2.7]                               
      Hemorrhage                                                    1 [4.0]                                                         
      Hemorrhage, Focal                                                                       1 [2.0]                               
      Pars Distalis, Cyst                              2 [1.5]      1 [3.0]      1 [2.0]      1 [2.0]                               
      Pars Distalis, Cytoplasmic Alteration, Focal     3 [1.3]      7 [1.4]      3 [1.0]      8 [1.4]                               
      Pars Distalis, Degeneration, Cystic, Focal       2 [1.0]      2 [3.0]                                                         
      Pars Distalis, Hemorrhage, Focal                 2 [3.0]      2 [2.5]      1 [2.0]      3 [2.7]                               
      Pars Distalis, Hyperplasia, Focal                4 [2.3]      2 [3.5]      3 [2.3]      1 [2.0]                               
      Pars Distalis, Pars Nervosa, Hemorrhage,                                                                                      
         Focal                                                                   1 [3.0]                                            
      Pars Intermedia, Hemorrhage, Focal                                         1 [2.0]                                            
      Rathke's Cleft, Cyst                                                                    1 [4.0]                               
      Rathke's Cleft, Hemorrhage                       1 [3.0]                   2 [2.5]      2 [3.0]                               
      Rathke's Cleft, Hyperplasia, Cystic                           1 [2.0]                                                         
   Thyroid Gland                                      (47)         (44)         (43)         (47)                                   
      C-Cell, Hyperplasia                             45 [1.8]     42 [2.0]     41 [2.0]     44 [1.8]                               
      C-Cell, Hyperplasia, Focal                                                 1 [2.0]                                            
      Follicle, Cyst                                   1 [2.0]                   1 [2.0]      2 [3.0]                               
      Follicle, Degeneration, Cystic, Focal            2 [1.5]                                                                      
      Follicle, Mineralization, Focal                 45 [1.1]     43 [1.1]     42 [2.0]     42 [2.3]                               
      Follicular Cell, Hypertrophy                     4 [1.3]     13 [1.2]     33 [1.5]     40 [2.0]                               
      Follicular Cell, Hypertrophy, Focal              1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)          (6)          (2)          (7)                                    
      Abdominal, Fibrosis                                                        1 [3.0]                                            
      Mediastinum, Hemorrhage                                       1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                                1 [3.0]                               
      Inflammation, Chronic                            1 [2.0]      1 [3.0]                   2 [2.5]                               
   Penis                                                           (2)                                                              
      Thrombosis                                                    1 [2.0]                                                         
   Preputial Gland                                    (48)         (49)         (50)         (50)                                   
      Atrophy                                                                                 1 [3.0]                               
      Cyst                                                          1 [2.0]      1 [2.0]                                            
      Degeneration, Cystic                                          2 [3.0]      1 [3.0]      2 [3.0]                               
      Hyperplasia, Cystic                                           1 [3.0]                   1 [3.0]                               
      Inflammation, Chronic                           22 [1.7]     12 [1.8]     18 [1.8]     20 [1.3]                               
      Necrosis                                                                                1 [3.0]                               
   Prostate                                           (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic                           21 [1.9]     23 [2.0]     29 [2.2]     30 [1.8]                               
      Mineralization, Focal                            3 [2.0]      2 [2.5]      3 [2.0]      4 [2.3]                               
      Epithelium, Hyperplasia, Focal                  11 [1.3]      4 [1.3]      2 [2.0]     11 [1.2]                               
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          4 [3.0]     10 [2.9]      9 [2.9]      6 [3.2]                               
      Bilateral, Atrophy                                            1 [3.0]                                                         
      Germinal Epithelium, Atrophy                                                            1 [3.0]                               
      Germinal Epithelium, Degeneration                1 [2.0]                                                                      
      Interstitial Cell, Hyperplasia, Focal            1 [1.0]      1 [2.0]      1 [2.0]      3 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (48)         (50)         (49)                                   
      Angiectasis                                                   1 [2.0]                                                         
      Atrophy                                                                                 1 [3.0]                               
      Fibrosis                                         2 [3.0]                                                                      
      Hyperplasia                                     28 [1.9]     35 [2.3]     41 [2.4]     40 [2.7]                               
      Myeloid Cell, Erythroid Cell, Hyperplasia        2 [2.5]                                                                      
   Lymph Node                                         (34)         (24)         (26)         (34)                                   
      Ectasia                                          1 [4.0]                                                                      
      Hemorrhage                                                                              1 [3.0]                               
      Deep Cervical, Hemorrhage                                                  1 [3.0]                                            
      Deep Cervical, Hyperplasia, Plasma Cell          1 [3.0]                                                                      
      Mediastinal, Angiectasis                                                   1 [3.0]                                            
      Mediastinal, Ectasia                             5 [2.6]      7 [3.0]      5 [3.0]      3 [3.3]                               
      Mediastinal, Hemorrhage                          3 [3.0]      2 [2.5]      2 [3.0]      1 [3.0]                               
      Mediastinal, Hyperplasia, Histiocytic                         3 [3.0]      2 [3.0]      1 [3.0]                               
      Mediastinal, Hyperplasia, Lymphoid               1 [3.0]                   1 [3.0]      3 [3.3]                               
      Mediastinal, Hyperplasia, Plasma Cell            1 [3.0]                   2 [3.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Infiltration Cellular,                                                                                           
        Polymorphonuclear                                           1 [3.0]                                                         
      Mediastinal, Inflammation, Chronic Active                                               1 [3.0]                               
      Mediastinal, Inflammation, Suppurative                        1 [3.0]                                                         
      Pancreatic, Angiectasis                          2 [3.0]                                                                      
      Pancreatic, Ectasia                              3 [2.7]      3 [3.0]      3 [3.0]      6 [2.8]                               
      Pancreatic, Hemorrhage                           5 [2.8]      3 [3.0]      1 [2.0]      1 [3.0]                               
      Pancreatic, Hyperplasia, Histiocytic             8 [3.0]      5 [3.0]      9 [3.0]      6 [3.0]                               
      Pancreatic, Hyperplasia, Lymphoid                1 [3.0]      1 [3.0]                                                         
      Pancreatic, Pigmentation                         1 [2.0]      1 [2.0]      1 [3.0]                                            
      Renal, Hemorrhage                                                          1 [3.0]                                            
      Renal, Hyperplasia, Focal, Histiocytic                        1 [3.0]                                                         
      Renal, Hyperplasia, Lymphoid                                  1 [3.0]                                                         
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (50)                                   
      Amyloid Deposition                                                                      1 [4.0]                               
      Ectasia                                          1 [3.0]      1 [3.0]      1 [3.0]      3 [3.7]                               
      Hemorrhage                                                    2 [2.5]      3 [3.0]                                            
      Hyperplasia, Focal, Histiocytic                  1 [2.0]                                                                      
      Hyperplasia, Histiocytic                         3 [3.0]      3 [3.0]                   1 [3.0]                               
      Hyperplasia, Lymphoid                            2 [3.0]      1 [3.0]                   1 [3.0]                               
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Amyloid Deposition                                            1 [3.0]                                                         
      Angiectasis, Focal                                            2 [3.0]      1 [3.0]      3 [2.3]                               
      Atrophy                                                                                 1 [2.0]                               
      Congestion                                       1 [3.0]                                1 [3.0]                               
      Fibrosis, Focal                                               2 [3.0]      2 [3.0]      4 [2.8]                               
      Hematopoietic Cell Proliferation                 2 [2.5]      6 [2.3]      4 [2.5]     11 [2.5]                               
      Hemorrhage                                       1 [3.0]      1 [2.0]                                                         
      Hyperplasia, Focal, Histiocytic                  1 [3.0]      1 [2.0]      2 [2.0]      1 [3.0]                               
      Infarct, Multiple                                                                       1 [3.0]                               
      Metaplasia, Focal, Lipocyte                                                1 [2.0]                                            
      Necrosis                                         1 [4.0]                                                                      
      Pigmentation                                                                            1 [3.0]                               
      Pigmentation, Focal                                                        1 [3.0]                                            
      Capsule, Accessory Spleen, Focal                 1 [2.0]                                                                      
      Capsule, Fibrosis, Focal                                                                1 [2.0]                               
      Lymphoid Follicle, Atrophy                                    1 [3.0]                                                         
   Thymus                                             (48)         (48)         (49)         (47)                                   
      Angiectasis                                                                1 [3.0]                                            
      Cyst                                                          1 [2.0]                                                         
      Hemorrhage                                       1 [3.0]      2 [2.5]      3 [2.3]                                            
      Hyperplasia, Lymphoid                                                      2 [2.5]      1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   15                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (43)         (47)         (44)                                   
      Cyst                                                                                    1 [3.0]                               
      Dilatation                                       7 [2.7]      7 [2.7]      7 [2.1]      2 [2.5]                               
      Hyperplasia                                                   1 [2.0]      2 [2.5]      2 [3.0]                               
      Inflammation, Chronic, Focal                     1 [2.0]                                1 [1.0]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        3 [3.3]      1 [3.0]      3 [2.3]      1 [2.0]                               
      Fibrosis, Focal                                               2 [3.0]                                                         
      Hyperkeratosis, Focal                            1 [3.0]                   1 [3.0]                                            
      Inflammation, Chronic, Focal                                  2 [3.0]                                                         
      Ulcer                                                         1 [3.0]                                                         
      Artery, Subcutaneous Tissue, Thrombosis                       1 [3.0]                                                         
      Epidermis, Hyperplasia, Focal                    1 [3.0]                                                                      
      Lip, Inflammation, Chronic, Focal                             1 [3.0]                                                         
      Subcutaneous Tissue, Cyst                                     1 [4.0]                                                         
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
        Inclusion                                                                1 [3.0]                                            
      Subcutaneous Tissue, Hyperplasia, Focal,                                                                                      
         Histiocytic                                                                          1 [3.0]                               
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
         Focal                                                      1 [3.0]                                                         
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
         Focal, Suppurative                                                      1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Cranium, Hyperostosis                                         1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression, Focal                               6 [3.2]      6 [2.8]      7 [3.0]      6 [3.0]                               
      Hemorrhage, Focal                                2 [2.5]      2 [3.5]      4 [1.3]      6 [2.7]                               
      Cerebrum, Ventricle, Hydrocephalus                            1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   16                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       2 [2.0]      1 [3.0]      3 [3.0]                                            
      Foreign Body, Focal                              1 [2.0]                                                                      
      Hemorrhage                                                                 1 [2.0]                                            
      Hemorrhage, Focal                                3 [1.3]      1 [2.0]      2 [2.0]      2 [2.0]                               
      Hyperplasia, Focal, Histiocytic                               1 [1.0]      1 [1.0]                                            
      Hyperplasia, Histiocytic                         2 [1.0]      1 [1.0]      1 [1.0]      2 [1.0]                               
      Infiltration Cellular, Mixed Cell                1 [2.0]      3 [2.0]      1 [2.0]      2 [2.5]                               
      Inflammation, Chronic, Focal                     5 [2.2]      2 [1.0]      3 [1.3]      3 [1.7]                               
      Inflammation, Focal, Suppurative                              1 [3.0]                                                         
      Alveolar Epithelium, Hyperplasia, Focal          8 [1.9]      5 [1.6]      3 [2.0]      4 [2.8]                               
      Alveolar Epithelium, Metaplasia, Squamous                     1 [3.0]                                                         
      Alveolus, Edema, Focal                                                     1 [2.0]                                            
      Alveolus, Hyperplasia, Focal, Histiocytic        1 [3.0]                                                                      
      Interstitium, Edema                                           1 [3.0]                   1 [3.0]                               
      Mediastinum, Edema                                            1 [3.0]      1 [3.0]                                            
   Nose                                               (49)         (49)         (49)         (50)                                   
      Foreign Body                                                  1 [2.0]      2 [2.0]      1 [2.0]                               
      Inflammation, Chronic                            1 [2.0]                                                                      
      Inflammation, Suppurative                        1 [2.0]      1 [3.0]      6 [2.0]      1 [2.0]                               
      Nasolacrimal Duct, Inflammation                  1 [1.0]      3 [2.0]                   1 [2.0]                               
      Olfactory Epithelium, Hyperplasia, Focal                                   1 [2.0]                                            
      Respiratory Epithelium, Hyperplasia, Focal                                 1 [3.0]                                            
   Trachea                                            (50)         (49)         (50)         (50)                                   
      Peritracheal Tissue, Edema                                    1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (48)         (46)         (50)                                   
      Atrophy                                                                                 2 [3.0]                               
      Cataract                                                      2 [2.5]      1 [3.0]      2 [2.5]                               
      Exudate                                                       1 [3.0]                                                         
      Cornea, Inflammation, Chronic                                              1 [3.0]                                            
      Cornea, Retrobulbar, Inflammation, Chronic                                                                                    
        Active                                                                                1 [3.0]                               
      Retina, Degeneration                                          2 [3.5]      1 [3.0]      2 [3.0]                               
   Harderian Gland                                    (49)         (49)         (49)         (50)                                   
      Fibrosis, Focal                                                                         1 [2.0]                               
      Hyperplasia, Focal, Histiocytic                               1 [2.0]      1 [2.0]      1 [1.0]                               
      Inflammation, Chronic, Focal                                  1 [3.0]      1 [1.0]      1 [2.0]                               
      Inflammation, Chronic Active, Diffuse                                                   1 [4.0]                               
      Epithelium, Hyperplasia, Focal                   1 [2.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   17                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 05/27/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 14:06:14    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        0 MG/L       125 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (47)         (46)         (49)         (49)                                   
      Cyst                                                                       1 [2.0]                                            
      Cyst, Multiple                                                1 [2.0]                                                         
      Hydronephrosis                                                1 [4.0]                                                         
      Infarct                                                                    1 [3.0]                                            
      Infarct, Multiple                                1 [4.0]      1 [3.0]                                                         
      Metaplasia, Focal, Lipocyte                                   1 [3.0]                                                         
      Nephropathy                                     45 [1.6]     44 [1.7]     48 [1.8]     47 [1.7]                               
      Cortex, Medulla, Atrophy                                      1 [4.0]                                                         
      Pelvis, Infiltration Cellular, Mixed Cell                                               1 [2.0]                               
      Pelvis, Transitional Epithelium, Hyperplasia                  1 [2.0]      1 [2.0]                                            
      Renal Tubule, Accumulation, Hyaline Droplet                   1 [2.0]      4 [2.3]      2 [2.5]                               
      Renal Tubule, Hyperplasia, Focal                              1 [2.0]                                                         
      Renal Tubule, Pigmentation                       4 [2.3]      4 [1.8]      1 [2.0]      4 [2.8]                               
   Urinary Bladder                                    (48)         (49)         (47)         (50)                                   
      Calculus Micro Observation Only                               1 [3.0]                                                         
      Edema                                                                                   2 [3.0]                               
      Hemorrhage                                                                 2 [2.0]                                            
      Inflammation, Chronic                                                      1 [4.0]                                            
      Serosa, Inflammation, Focal                                                             1 [2.0]                               
      Transitional Epithelium, Hyperplasia, Diffuse                 1 [2.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   18                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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