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TDMS Study 96010-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:41:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
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                                                            FINAL#1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:41:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:41:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF     WATER DISINFECTION BYPRODUCTS (SODIUM                                                                        
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hepatoblastoma                                                                               
Testes                                 Adenoma                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Medulla                        Pheochromocytoma Malignant                                                                   
Islets, Pancreatic                     Carcinoma or Adenoma                                                                         
Liver                                  Hemangioma                                                                                   
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
Ovary                                  Granulosa Cell Tumor Benign                                                                  
                                       Granulosa Cell Tumor: Benign, Malignant, NOS                                                 
                                       Luteoma                                                                                      
Skin                                   Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
                                       Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                  
Uterus                                 Polyp Stromal                                                                                
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -      WATER DISINFECTION BYPRODUCTS (SODIUM     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    5/50 (10%)   3/50 (6%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.60      4/47.28      5/46.48      3/43.80     |1/43.63      0/44.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     6.7%         8.5%         10.8%        6.9%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/38 (8%)    4/41 (10%)   5/41 (12%)   3/33 (9%)   |1/36 (3%)    0/34 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.500      P=0.542      P=0.398      P=0.597     |P=0.313N     P=0.511N     P=0.530N     P=0.506N     | 
|POLY 3             |     P=0.566      P=0.532      P=0.379      P=0.654     |P=0.310N     P=0.497N     P=0.508N     P=0.501N     | 
|POLY 1.5           |     P=0.566N     P=0.519      P=0.372      P=0.658     |P=0.309N     P=0.499N     P=0.509N     P=0.502N     | 
|POLY 6             |     P=0.550      P=0.547      P=0.387      P=0.648     |P=0.313N     P=0.493N     P=0.507N     P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.500      P=0.542      P=0.398      P=0.597     |P=0.313N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.554N     P=0.500      P=0.357      P=0.661N    |P=0.306N     P=0.505N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.564      (e)          (e)          (e)         |P=0.121N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.98      0/45.28      0/45.48      0/42.80     |2/43.88      0/44.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/39 (0%)    0/40 (0%)    0/32 (0%)   |1/36 (3%)    0/34 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |660          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.233N     P=0.256N     P=0.237N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.117N     P=0.235N     P=0.247N     P=0.239N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.237N     P=0.248N     P=0.240N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.232N     P=0.247N     P=0.239N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.116N     P=0.241N     P=0.245N     P=0.238N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.253N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.030N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |3/50 (6%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.98      0/45.28      0/45.48      0/42.80     |3/43.88      0/44.35      0/42.00      2/43.58      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.8%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/39 (0%)    0/40 (0%)    0/32 (0%)   |2/36 (6%)    0/34 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |660          ---          ---          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.532N     P=0.122N     P=0.141N     P=0.496N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.538N     P=0.117N     P=0.126N     P=0.503N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.536N     P=0.119N     P=0.127N     P=0.504N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.541N     P=0.114N     P=0.127N     P=0.501N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.535N     P=0.119N     P=0.127N     P=0.502N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.529N     P=0.125N     P=0.125N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.102N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/43.63      1/45.39      1/42.71      2/44.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.3%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          719          622          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.247      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.156      P=0.508      P=0.496      P=0.242      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.239      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.512      P=0.496      P=0.246      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.167      P=0.511      P=0.520      P=0.273      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.53      0/47.28      0/46.48      0/43.80     |1/44.05      1/45.35      2/42.58      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         2.2%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    1/35 (3%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |606          729 (T)      662          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.371N     P=0.758N     P=0.483      P=0.495N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.376N     P=0.754N     P=0.488      P=0.503N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.374N     P=0.756N     P=0.489      P=0.503N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.377N     P=0.752N     P=0.487      P=0.503N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.366N     P=0.752      P=0.506      P=0.482N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366N     P=0.753N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    4/50 (8%)    6/50 (12%)  |11/50 (22%)  9/50 (18%)   5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     6/45.47      4/47.40      4/47.28      6/44.51     |11/44.13     9/45.61      5/42.40      6/43.85      | 
|POLY-3 PERCENT (g) |     13.2%        8.4%         8.5%         13.5%       |24.9%        19.7%        11.8%        13.7%        | 
|TERMINAL (d)       |     4/38 (11%)   3/41 (7%)    2/41 (5%)    3/33 (9%)   |10/36 (28%)  7/35 (20%)   4/31 (13%)   5/35 (14%)   | 
|FIRST INCIDENCE    |     562          698          543          605         |576          673          712          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.422      P=0.323N     P=0.333N     P=0.556     |P=0.104N     P=0.420N     P=0.142N     P=0.157N     | 
|POLY 3             |     P=0.478      P=0.344N     P=0.345N     P=0.606     |P=0.093N     P=0.368N     P=0.095N     P=0.142N     | 
|POLY 1.5           |     P=0.487      P=0.353N     P=0.353N     P=0.612     |P=0.093N     P=0.380N     P=0.095N     P=0.145N     | 
|POLY 6             |     P=0.466      P=0.332N     P=0.338N     P=0.596     |P=0.092N     P=0.351N     P=0.097N     P=0.137N     | 
|LOGISTIC REGRESSION|     P=0.511      P=0.375N     P=0.417N     P=0.621N    |P=0.093N     P=0.348N     P=0.095N     P=0.143N     | 
|COCH-ARM / FISHERS |     P=0.500      P=0.370N     P=0.370N     P=0.620N    |P=0.088N     P=0.402N     P=0.086N     P=0.143N     | 
|ORDER RESTRICTED   |     P=0.473      (e)          (e)          (e)         |P=0.100N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    5/50 (10%)   7/50 (14%)  |12/50 (24%)  10/50 (20%)  5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     6/45.47      4/47.40      5/47.28      7/44.97     |12/44.13     10/46.13     5/42.40      6/43.85      | 
|POLY-3 PERCENT (g) |     13.2%        8.4%         10.6%        15.6%       |27.2%        21.7%        11.8%        13.7%        | 
|TERMINAL (d)       |     4/38 (11%)   3/41 (7%)    3/41 (7%)    3/33 (9%)   |11/36 (31%)  7/35 (20%)   4/31 (13%)   5/35 (14%)   | 
|FIRST INCIDENCE    |     562          698          543          595         |576          568          712          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.281      P=0.323N     P=0.453N     P=0.442     |P=0.063N     P=0.426N     P=0.097N     P=0.107N     | 
|POLY 3             |     P=0.335      P=0.344N     P=0.473N     P=0.491     |P=0.053N     P=0.358N     P=0.060N     P=0.094N     | 
|POLY 1.5           |     P=0.342      P=0.353N     P=0.481N     P=0.495     |P=0.053N     P=0.375N     P=0.061N     P=0.096N     | 
|POLY 6             |     P=0.326      P=0.332N     P=0.465N     P=0.485     |P=0.054N     P=0.334N     P=0.061N     P=0.090N     | 
|LOGISTIC REGRESSION|     P=0.366      P=0.375N     P=0.543N     P=0.504     |P=0.054N     P=0.365N     P=0.060N     P=0.095N     | 
|COCH-ARM / FISHERS |     P=0.351      P=0.370N     P=0.500N     P=0.500     |P=0.050N     P=0.405N     P=0.054N     P=0.096N     | 
|ORDER RESTRICTED   |     P=0.383      (e)          (e)          (e)         |P=0.059N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Duodenum                                                                                                        | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      2/46.48      0/43.80     |0/43.63      0/45.35      0/42.33      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566      (e)          P=0.255      (e)         |P=0.199      (e)          (e)          P=0.494      | 
|POLY 3             |     P=0.573      (e)          P=0.246      (e)         |P=0.196      (e)          (e)          P=0.499      | 
|POLY 1.5           |     P=0.582      (e)          P=0.243      (e)         |P=0.196      (e)          (e)          P=0.498      | 
|POLY 6             |     P=0.558      (e)          P=0.250      (e)         |P=0.196      (e)          (e)          P=0.500      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.255      (e)         |(e)          (e)          (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.255      (e)          (e)          (e)         |P=0.119      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.60      2/47.28      0/46.48      2/44.39     |0/43.63      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     4.5%         4.2%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    2/41 (5%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          570         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.599N     P=0.667N     P=0.222N     P=0.666     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.557N     P=0.673N     P=0.228N     P=0.692     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.556N     P=0.681N     P=0.231N     P=0.693     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.559N     P=0.663N     P=0.225N     P=0.690     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.555N     P=0.667N     (e)          P=0.694N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.691N     P=0.247N     P=0.691N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.437N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.60      2/47.28      0/46.48      3/44.39     |0/43.63      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     4.5%         4.2%         0.0%         6.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    2/41 (5%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          570         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.373      P=0.667N     P=0.222N     P=0.461     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.418      P=0.673N     P=0.228N     P=0.498     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.420      P=0.681N     P=0.231N     P=0.499     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.414      P=0.663N     P=0.225N     P=0.495     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.420      P=0.667N     (e)          P=0.499     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.423      P=0.691N     P=0.247N     P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.277      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.60      2/47.28      1/46.48      4/44.39     |0/43.63      1/45.45      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     6.7%         4.2%         2.2%         9.0%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/38 (8%)    2/41 (5%)    1/41 (2%)    2/33 (6%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      570         |---          706          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309      P=0.465N     P=0.278N     P=0.445     |P=0.582N     P=0.520      (e)          (e)          | 
|POLY 3             |     P=0.362      P=0.473N     P=0.291N     P=0.497     |P=0.565N     P=0.508      (e)          (e)          | 
|POLY 1.5           |     P=0.366      P=0.484N     P=0.296N     P=0.499     |P=0.567N     P=0.505      (e)          (e)          | 
|POLY 6             |     P=0.356      P=0.461N     P=0.286N     P=0.494     |P=0.563N     P=0.512      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.358      P=0.465N     P=0.278N     P=0.494     |P=0.570N     P=0.505      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.371      P=0.500N     P=0.309N     P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.270      (e)          (e)          (e)         |P=0.389N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      2/46.48      0/43.80     |0/43.63      0/45.35      0/42.33      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566      (e)          P=0.255      (e)         |P=0.199      (e)          (e)          P=0.494      | 
|POLY 3             |     P=0.573      (e)          P=0.246      (e)         |P=0.196      (e)          (e)          P=0.499      | 
|POLY 1.5           |     P=0.582      (e)          P=0.243      (e)         |P=0.196      (e)          (e)          P=0.498      | 
|POLY 6             |     P=0.558      (e)          P=0.250      (e)         |P=0.196      (e)          (e)          P=0.500      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.255      (e)         |(e)          (e)          (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.255      (e)          (e)          (e)         |P=0.119      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/46 (0%)    2/47 (4%)    2/49 (4%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     1/43.91      0/47.28      0/46.48      1/43.84     |0/42.28      2/44.36      2/42.00      3/43.88      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         2.3%        |0.0%         4.5%         4.8%         6.8%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    1/35 (3%)    2/31 (7%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          719         |---          706          729 (T)      475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      P=0.485N     P=0.485N     P=0.735     |P=0.106      P=0.248      P=0.206      P=0.126      | 
|POLY 3             |     P=0.591      P=0.485N     P=0.489N     P=0.760     |P=0.112      P=0.248      P=0.235      P=0.125      | 
|POLY 1.5           |     P=0.595      P=0.488N     P=0.490N     P=0.758N    |P=0.113      P=0.245      P=0.238      P=0.125      | 
|POLY 6             |     P=0.585      P=0.481N     P=0.487N     P=0.756     |P=0.112      P=0.252      P=0.232      P=0.126      | 
|LOGISTIC REGRESSION|     P=0.583      (e)          (e)          P=0.752     |P=0.127      P=0.248      P=0.206      P=0.171      | 
|COCH-ARM / FISHERS |     P=0.602      P=0.490N     P=0.490N     P=0.742N    |P=0.121      P=0.253      P=0.263      P=0.133      | 
|ORDER RESTRICTED   |     P=0.393      (e)          (e)          (e)         |P=0.082      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/46 (0%)    2/47 (4%)    2/49 (4%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     1/43.91      0/47.28      0/46.48      2/43.84     |0/42.28      2/44.36      2/42.00      4/43.88      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         4.6%        |0.0%         4.5%         4.8%         9.1%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    1/35 (3%)    2/31 (7%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          719         |---          706          729 (T)      475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210      P=0.485N     P=0.485N     P=0.458     |P=0.043 *    P=0.248      P=0.206      P=0.066      | 
|POLY 3             |     P=0.243      P=0.485N     P=0.489N     P=0.499     |P=0.045 *    P=0.248      P=0.235      P=0.065      | 
|POLY 1.5           |     P=0.246      P=0.488N     P=0.490N     P=0.505     |P=0.046 *    P=0.245      P=0.238      P=0.065      | 
|POLY 6             |     P=0.238      P=0.481N     P=0.487N     P=0.492     |P=0.045 *    P=0.252      P=0.232      P=0.065      | 
|LOGISTIC REGRESSION|     P=0.222      (e)          (e)          P=0.479     |P=0.052      P=0.248      P=0.206      P=0.087      | 
|COCH-ARM / FISHERS |     P=0.252      P=0.490N     P=0.490N     P=0.515     |P=0.051      P=0.253      P=0.263      P=0.067      | 
|ORDER RESTRICTED   |     P=0.128      (e)          (e)          (e)         |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/49 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      1/46.48      0/43.80     |2/43.57      0/45.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |4.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |2/36 (6%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.515      (e)         |P=0.123N     P=0.244N     P=0.272N     P=0.244N     | 
|POLY 3             |     P=0.675      (e)          P=0.511      (e)         |P=0.114N     P=0.228N     P=0.245N     P=0.238N     | 
|POLY 1.5           |     P=0.684      (e)          P=0.510      (e)         |P=0.114N     P=0.231N     P=0.246N     P=0.238N     | 
|POLY 6             |     P=0.662      (e)          P=0.513      (e)         |P=0.116N     P=0.224N     P=0.245N     P=0.237N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      (e)         |P=0.123N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.699      (e)          P=0.510      (e)         |P=0.114N     P=0.242N     P=0.247N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.391      (e)          (e)          (e)         |P=0.030N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |1/49 (2%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.91      2/47.28      1/46.48      2/43.80     |1/43.57      2/45.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     2.3%         4.2%         2.2%         4.6%        |2.3%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    2/41 (5%)    1/41 (2%)    2/33 (6%)   |1/36 (3%)    2/35 (6%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.385      P=0.527      P=0.745N     P=0.451     |P=0.198N     P=0.490      P=0.530N     P=0.506N     | 
|POLY 3             |     P=0.437      P=0.526      P=0.748N     P=0.499     |P=0.190N     P=0.514      P=0.507N     P=0.501N     | 
|POLY 1.5           |     P=0.444      P=0.520      P=0.749N     P=0.505     |P=0.190N     P=0.510      P=0.508N     P=0.501N     | 
|POLY 6             |     P=0.428      P=0.533      P=0.746N     P=0.492     |P=0.189N     P=0.520      P=0.507N     P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.385      P=0.527      P=0.745N     P=0.451     |P=0.198N     P=0.490      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.456      P=0.515      P=0.742N     P=0.515     |P=0.186N     P=0.508      P=0.500N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.442      (e)          (e)          (e)         |P=0.175N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/48 (13%)   3/50 (6%)    1/50 (2%)    3/50 (6%)   |1/49 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/44.45      3/47.85      1/46.71      3/43.84     |1/43.57      0/45.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     13.5%        6.3%         2.1%         6.8%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/38 (13%)   1/41 (2%)    0/41 (0%)    2/33 (6%)   |1/36 (3%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     561          577          668          719         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.222N     P=0.212N     P=0.051N     P=0.307N    |P=0.313N     P=0.506N     P=0.530N     P=0.506N     | 
|POLY 3             |     P=0.179N     P=0.207N     P=0.048N*    P=0.248N    |P=0.306N     P=0.492N     P=0.507N     P=0.501N     | 
|POLY 1.5           |     P=0.174N     P=0.214N     P=0.049N*    P=0.239N    |P=0.305N     P=0.494N     P=0.508N     P=0.501N     | 
|POLY 6             |     P=0.186N     P=0.197N     P=0.047N*    P=0.261N    |P=0.308N     P=0.489N     P=0.507N     P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.158N     P=0.238N     P=0.054N     P=0.239N    |P=0.313N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.166N     P=0.223N     P=0.050N     P=0.223N    |P=0.304N     P=0.495N     P=0.500N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.076N     (e)          (e)          (e)         |P=0.121N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/48 (63%)  32/50 (64%)  36/50 (72%)  30/50 (60%) |30/49 (61%)  19/50 (38%)  26/49 (53%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     30/46.51     32/47.31     36/48.04     30/45.77    |30/45.42     19/45.74     26/43.41     23/44.75     | 
|POLY-3 PERCENT (g) |     64.5%        67.6%        74.9%        65.5%       |66.1%        41.5%        59.9%        51.4%        | 
|TERMINAL (d)       |     25/38 (66%)  31/41 (76%)  32/41 (78%)  24/33 (73%) |26/36 (72%)  17/35 (49%)  19/31 (61%)  20/35 (57%)  | 
|FIRST INCIDENCE    |     484          722          543          535         |524          674          602          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.185      P=0.563N     P=0.300      P=0.310     |P=0.289N     P=0.023N*    P=0.537N     P=0.132N     | 
|POLY 3             |     P=0.478      P=0.459      P=0.184      P=0.546     |P=0.252N     P=0.013N*    P=0.348N     P=0.108N     | 
|POLY 1.5           |     P=0.533      P=0.482      P=0.197      P=0.577N    |P=0.248N     P=0.014N*    P=0.350N     P=0.108N     | 
|POLY 6             |     P=0.417      P=0.438      P=0.172      P=0.492     |P=0.252N     P=0.011N*    P=0.339N     P=0.104N     | 
|LOGISTIC REGRESSION|     P=0.500      P=0.584N     P=0.228      P=0.549N    |P=0.263N     P=0.010N*    P=0.331N     P=0.108N     | 
|COCH-ARM / FISHERS |     P=0.449N     P=0.522      P=0.216      P=0.482N    |P=0.214N     P=0.017N*    P=0.270N     P=0.094N     | 
|ORDER RESTRICTED   |     P=0.427      (e)          (e)          (e)         |P=0.100N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/48 (42%)  14/50 (28%)  19/50 (38%)  13/50 (26%) |3/49 (6%)    13/50 (26%)  15/49 (31%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     20/46.21     14/48.93     19/48.53     13/45.80    |3/43.65      13/45.65     15/42.18     9/44.29      | 
|POLY-3 PERCENT (g) |     43.3%        28.6%        39.2%        28.4%       |6.9%         28.5%        35.6%        20.3%        | 
|TERMINAL (d)       |     14/38 (37%)  10/41 (24%)  14/41 (34%)  5/33 (15%)  |2/36 (6%)    9/35 (26%)   12/31 (39%)  7/35 (20%)   | 
|FIRST INCIDENCE    |     484          431          558          570         |710          682          711          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276N     P=0.110N     P=0.400N     P=0.200N    |P=0.154      P=0.009 **   P<0.001 **   P=0.060      | 
|POLY 3             |     P=0.159N     P=0.099N     P=0.421N     P=0.100N    |P=0.158      P=0.007 **   P<0.001 **   P=0.061      | 
|POLY 1.5           |     P=0.144N     P=0.105N     P=0.427N     P=0.091N    |P=0.157      P=0.007 **   P<0.001 **   P=0.061      | 
|POLY 6             |     P=0.176N     P=0.093N     P=0.416N     P=0.109N    |P=0.164      P=0.008 **   P<0.001 **   P=0.063      | 
|LOGISTIC REGRESSION|     P=0.084N     P=0.142N     P=0.462N     P=0.068N    |P=0.150      P=0.009 **   P<0.001 **   P=0.062      | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.113N     P=0.435N     P=0.077N    |P=0.179      P=0.007 **   P=0.002 **   P=0.065      | 
|ORDER RESTRICTED   |     P=0.104N     (e)          (e)          (e)         |P=0.010 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/48 (48%)  16/50 (32%)  20/50 (40%)  16/50 (32%) |4/49 (8%)    13/50 (26%)  15/49 (31%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     23/46.76     16/49.00     20/48.76     16/45.84    |4/43.65      13/45.65     15/42.18     9/44.29      | 
|POLY-3 PERCENT (g) |     49.2%        32.7%        41.0%        34.9%       |9.2%         28.5%        35.6%        20.3%        | 
|TERMINAL (d)       |     16/38 (42%)  11/41 (27%)  14/41 (34%)  7/33 (21%)  |3/36 (8%)    9/35 (26%)   12/31 (39%)  7/35 (20%)   | 
|FIRST INCIDENCE    |     484          431          558          570         |710          682          711          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313N     P=0.084N     P=0.267N     P=0.232N    |P=0.208      P=0.020 *    P=0.002 **   P=0.112      | 
|POLY 3             |     P=0.180N     P=0.074N     P=0.276N     P=0.117N    |P=0.219      P=0.018 *    P=0.002 **   P=0.119      | 
|POLY 1.5           |     P=0.160N     P=0.076N     P=0.278N     P=0.102N    |P=0.217      P=0.017 *    P=0.003 **   P=0.118      | 
|POLY 6             |     P=0.203N     P=0.070N     P=0.272N     P=0.133N    |P=0.226      P=0.020 *    P=0.002 **   P=0.123      | 
|LOGISTIC REGRESSION|     P=0.091N     P=0.106N     P=0.306N     P=0.073N    |P=0.207      P=0.022 *    P=0.003 **   P=0.116      | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.080N     P=0.279N     P=0.080N    |P=0.241      P=0.017 *    P=0.005 **   P=0.125      | 
|ORDER RESTRICTED   |     P=0.126N     (e)          (e)          (e)         |P=0.022 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/48 (85%)  42/50 (84%)  44/50 (88%)  40/50 (80%) |31/49 (63%)  26/50 (52%)  31/49 (63%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     41/47.67     42/48.96     44/49.35     40/47.50    |31/45.50     26/45.86     31/43.48     26/44.92     | 
|POLY-3 PERCENT (g) |     86.0%        85.8%        89.2%        84.2%       |68.1%        56.7%        71.3%        57.9%        | 
|TERMINAL (d)       |     32/38 (84%)  37/41 (90%)  37/41 (90%)  27/33 (82%) |26/36 (72%)  21/35 (60%)  23/31 (74%)  22/35 (63%)  | 
|FIRST INCIDENCE    |     484          431          543          535         |524          674          602          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      P=0.404N     P=0.576N     P=0.333     |P=0.340N     P=0.239N     P=0.292      P=0.249N     | 
|POLY 3             |     P=0.477N     P=0.604N     P=0.434      P=0.517N    |P=0.287N     P=0.174N     P=0.461      P=0.207N     | 
|POLY 1.5           |     P=0.416N     P=0.574N     P=0.450      P=0.455N    |P=0.283N     P=0.176N     P=0.467      P=0.206N     | 
|POLY 6             |     P=0.525N     P=0.597      P=0.411      P=0.571N    |P=0.286N     P=0.164N     P=0.464      P=0.202N     | 
|LOGISTIC REGRESSION|     P=0.371N     P=0.523N     P=0.466      P=0.394N    |P=0.297N     P=0.123N     P=0.493      P=0.204N     | 
|COCH-ARM / FISHERS |     P=0.289N     P=0.535N     P=0.468      P=0.330N    |P=0.237N     P=0.176N     P=0.583N     P=0.176N     | 
|ORDER RESTRICTED   |     P=0.539N     (e)          (e)          (e)         |P=0.233N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/48 (85%)  43/50 (86%)  45/50 (90%)  40/50 (80%) |31/49 (63%)  26/50 (52%)  31/49 (63%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     41/47.67     43/49.02     45/49.58     40/47.50    |31/45.50     26/45.86     31/43.48     26/44.92     | 
|POLY-3 PERCENT (g) |     86.0%        87.7%        90.8%        84.2%       |68.1%        56.7%        71.3%        57.9%        | 
|TERMINAL (d)       |     32/38 (84%)  37/41 (90%)  37/41 (90%)  27/33 (82%) |26/36 (72%)  21/35 (60%)  23/31 (74%)  22/35 (63%)  | 
|FIRST INCIDENCE    |     484          431          543          535         |524          674          602          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.212      P=0.481N     P=0.508      P=0.333     |P=0.340N     P=0.239N     P=0.292      P=0.249N     | 
|POLY 3             |     P=0.448N     P=0.522      P=0.337      P=0.517N    |P=0.287N     P=0.174N     P=0.461      P=0.207N     | 
|POLY 1.5           |     P=0.387N     P=0.547      P=0.342      P=0.455N    |P=0.283N     P=0.176N     P=0.467      P=0.206N     | 
|POLY 6             |     P=0.498N     P=0.490      P=0.332      P=0.571N    |P=0.286N     P=0.164N     P=0.464      P=0.202N     | 
|LOGISTIC REGRESSION|     P=0.338N     P=0.594      P=0.344      P=0.394N    |P=0.297N     P=0.123N     P=0.493      P=0.204N     | 
|COCH-ARM / FISHERS |     P=0.259N     P=0.581      P=0.351      P=0.330N    |P=0.237N     P=0.176N     P=0.583N     P=0.176N     | 
|ORDER RESTRICTED   |     P=0.440N     (e)          (e)          (e)         |P=0.233N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    7/50 (14%)   6/50 (12%)  |3/50 (6%)    1/50 (2%)    0/49 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     6/44.60      4/47.71      7/47.00      6/43.91     |3/43.98      1/45.35      0/41.33      3/43.40      | 
|POLY-3 PERCENT (g) |     13.5%        8.4%         14.9%        13.7%       |6.8%         2.2%         0.0%         6.9%         | 
|TERMINAL (d)       |     6/38 (16%)   3/41 (7%)    6/41 (15%)   4/33 (12%)  |2/36 (6%)    1/35 (3%)    0/30 (0%)    3/35 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      604          570          711         |630          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.354      P=0.324N     P=0.556      P=0.528     |P=0.512      P=0.308N     P=0.148N     P=0.653      | 
|POLY 3             |     P=0.423      P=0.328N     P=0.540      P=0.610     |P=0.513      P=0.294N     P=0.130N     P=0.657      | 
|POLY 1.5           |     P=0.437      P=0.344N     P=0.526      P=0.615     |P=0.515      P=0.298N     P=0.129N     P=0.657      | 
|POLY 6             |     P=0.403      P=0.308N     P=0.556      P=0.602     |P=0.509      P=0.290N     P=0.132N     P=0.657      | 
|LOGISTIC REGRESSION|     P=0.427      P=0.333N     P=0.535      P=0.573     |P=0.516      P=0.296N     P=0.128N     P=0.662      | 
|COCH-ARM / FISHERS |     P=0.455      P=0.370N     P=0.500      P=0.620N    |P=0.525      P=0.309N     P=0.125N     P=0.661N     | 
|ORDER RESTRICTED   |     P=0.496      (e)          (e)          (e)         |P=0.284      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   7/50 (14%)   4/50 (8%)   |1/50 (2%)    1/50 (2%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/45.19      5/47.28      7/47.72      4/44.15     |1/43.63      1/45.35      2/41.40      1/43.40      | 
|POLY-3 PERCENT (g) |     8.9%         10.6%        14.7%        9.1%        |2.3%         2.2%         4.8%         2.3%         | 
|TERMINAL (d)       |     2/38 (5%)    5/41 (12%)   4/41 (10%)   2/33 (6%)   |1/36 (3%)    1/35 (3%)    1/30 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     638          729 (T)      543          640         |729 (T)      729 (T)      712          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.481      P=0.550      P=0.314      P=0.590     |P=0.575      P=0.756      P=0.455      P=0.756      | 
|POLY 3             |     P=0.534      P=0.528      P=0.293      P=0.631     |P=0.581      P=0.752N     P=0.482      P=0.760      | 
|POLY 1.5           |     P=0.547      P=0.518      P=0.282      P=0.636     |P=0.582      P=0.755N     P=0.482      P=0.759      | 
|POLY 6             |     P=0.516      P=0.539      P=0.305      P=0.621     |P=0.581      P=0.748N     P=0.481      P=0.761N     | 
|LOGISTIC REGRESSION|     P=0.559N     P=0.522      P=0.219      P=0.641     |P=0.580      P=0.756      P=0.477      P=0.756      | 
|COCH-ARM / FISHERS |     P=0.563      P=0.500      P=0.262      P=0.643N    |P=0.590      P=0.753N     P=0.492      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.505      (e)          (e)          (e)         |P=0.563      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  8/50 (16%)   13/50 (26%)  9/50 (18%)  |4/50 (8%)    2/50 (4%)    2/49 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     10/45.19     8/47.71      13/48.25     9/44.27     |4/43.98      2/45.35      2/41.40      4/43.40      | 
|POLY-3 PERCENT (g) |     22.1%        16.8%        27.0%        20.3%       |9.1%         4.4%         4.8%         9.2%         | 
|TERMINAL (d)       |     8/38 (21%)   7/41 (17%)   9/41 (22%)   5/33 (15%)  |3/36 (8%)    2/35 (6%)    1/30 (3%)    4/35 (11%)   | 
|FIRST INCIDENCE    |     638          604          543          640         |630          729 (T)      712          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.418      P=0.331N     P=0.398      P=0.590     |P=0.479      P=0.343N     P=0.402N     P=0.631      | 
|POLY 3             |     P=0.505      P=0.349N     P=0.383      P=0.520N    |P=0.482      P=0.323N     P=0.365N     P=0.636      | 
|POLY 1.5           |     P=0.523      P=0.367N     P=0.359      P=0.511N    |P=0.486      P=0.328N     P=0.363N     P=0.637      | 
|POLY 6             |     P=0.480      P=0.328N     P=0.408      P=0.536N    |P=0.478      P=0.317N     P=0.369N     P=0.636      | 
|LOGISTIC REGRESSION|     P=0.537      P=0.358N     P=0.310      P=0.524N    |P=0.486      P=0.318N     P=0.362N     P=0.644      | 
|COCH-ARM / FISHERS |     P=0.548      P=0.398N     P=0.318      P=0.500N    |P=0.499      P=0.339N     P=0.349N     P=0.643N     | 
|ORDER RESTRICTED   |     P=0.488      (e)          (e)          (e)         |P=0.449      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Choriocarcinoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/45 (0%)    0/45 (0%)    2/47 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/39.57      0/41.72      2/40.43      0/43.40      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         5.0%         0.0%         | 
|TERMINAL (d)       |                                                        |0/32 (0%)    0/34 (0%)    1/30 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          683          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.602      (e)          P=0.233      (e)          | 
|POLY 3             |                                                        |P=0.604      (e)          P=0.241      (e)          | 
|POLY 1.5           |                                                        |P=0.606      (e)          P=0.240      (e)          | 
|POLY 6             |                                                        |P=0.604      (e)          P=0.244      (e)          | 
|LOGISTIC REGRESSION|                                                        |P=0.612      (e)          P=0.241      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.617      (e)          P=0.258      (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.252      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/45 (2%)    4/45 (9%)    1/47 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/39.57      4/41.90      1/40.25      1/43.40      | 
|POLY-3 PERCENT (g) |                                                        |2.5%         9.6%         2.5%         2.3%         | 
|TERMINAL (d)       |                                                        |1/32 (3%)    3/34 (9%)    1/30 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      682          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.353N     P=0.204      P=0.748      P=0.742N     | 
|POLY 3             |                                                        |P=0.336N     P=0.196      P=0.757N     P=0.740N     | 
|POLY 1.5           |                                                        |P=0.338N     P=0.188      P=0.758N     P=0.741N     | 
|POLY 6             |                                                        |P=0.330N     P=0.208      P=0.755N     P=0.738N     | 
|LOGISTIC REGRESSION|                                                        |P=0.343N     P=0.204      P=0.748      P=0.742N     | 
|COCH-ARM / FISHERS |                                                        |P=0.332N     P=0.180      P=0.742N     P=0.726N     | 
|ORDER RESTRICTED   |                                                        |P=0.305N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor Benign                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/45 (2%)    1/45 (2%)    1/47 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |                                                        |1/39.57      1/41.72      1/40.25      5/43.40      | 
|POLY-3 PERCENT (g) |                                                        |2.5%         2.4%         2.5%         11.5%        | 
|TERMINAL (d)       |                                                        |1/32 (3%)    1/34 (3%)    1/30 (3%)    5/35 (14%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.031 *    P=0.748N     P=0.748      P=0.123      | 
|POLY 3             |                                                        |P=0.031 *    P=0.749N     P=0.757N     P=0.123      | 
|POLY 1.5           |                                                        |P=0.032 *    P=0.754N     P=0.758N     P=0.122      | 
|POLY 6             |                                                        |P=0.030 *    P=0.741N     P=0.755N     P=0.125      | 
|LOGISTIC REGRESSION|                                                        |P=0.031 *    P=0.748N     P=0.748      P=0.123      | 
|COCH-ARM / FISHERS |                                                        |P=0.035 *    P=0.753N     P=0.742N     P=0.128      | 
|ORDER RESTRICTED   |                                                        |P=0.036 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/45 (2%)    1/45 (2%)    1/47 (2%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |1/39.57      1/41.72      1/40.25      6/44.39      | 
|POLY-3 PERCENT (g) |                                                        |2.5%         2.4%         2.5%         13.5%        | 
|TERMINAL (d)       |                                                        |1/32 (3%)    1/34 (3%)    1/30 (3%)    5/35 (14%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.012 *    P=0.748N     P=0.748      P=0.073      | 
|POLY 3             |                                                        |P=0.012 *    P=0.749N     P=0.757N     P=0.075      | 
|POLY 1.5           |                                                        |P=0.012 *    P=0.754N     P=0.758N     P=0.075      | 
|POLY 6             |                                                        |P=0.011 *    P=0.741N     P=0.755N     P=0.077      | 
|LOGISTIC REGRESSION|                                                        |P=0.015 *    P=0.748N     P=0.748      P=0.089      | 
|COCH-ARM / FISHERS |                                                        |P=0.013 *    P=0.753N     P=0.742N     P=0.074      | 
|ORDER RESTRICTED   |                                                        |P=0.015 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Luteoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/45 (7%)    0/45 (0%)    1/47 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/39.78      0/41.72      1/40.25      0/43.40      | 
|POLY-3 PERCENT (g) |                                                        |7.5%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |                                                        |2/32 (6%)    0/34 (0%)    1/30 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |                                                        |674          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.084N     P=0.109N     P=0.326N     P=0.110N     | 
|POLY 3             |                                                        |P=0.079N     P=0.110N     P=0.300N     P=0.103N     | 
|POLY 1.5           |                                                        |P=0.078N     P=0.114N     P=0.302N     P=0.103N     | 
|POLY 6             |                                                        |P=0.082N     P=0.105N     P=0.298N     P=0.101N     | 
|LOGISTIC REGRESSION|                                                        |P=0.078N     P=0.111N     P=0.295N     P=0.104N     | 
|COCH-ARM / FISHERS |                                                        |P=0.075N     P=0.121N     P=0.292N     P=0.103N     | 
|ORDER RESTRICTED   |                                                        |P=0.016N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/47 (2%)    0/45 (0%)    0/49 (0%)   |3/46 (7%)    2/45 (4%)    4/48 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/42.10      1/44.28      0/42.54      0/42.80     |3/41.52      2/41.26      4/40.71      4/43.56      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |7.2%         4.9%         9.8%         9.2%         | 
|TERMINAL (d)       |     0/37 (0%)    1/38 (3%)    0/38 (0%)    0/32 (0%)   |3/35 (9%)    2/32 (6%)    4/30 (13%)   3/35 (9%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.591N     P=0.505      (e)          (e)         |P=0.339      P=0.541N     P=0.415      P=0.500      | 
|POLY 3             |     P=0.553N     P=0.510      (e)          (e)         |P=0.356      P=0.503N     P=0.489      P=0.526      | 
|POLY 1.5           |     P=0.556N     P=0.506      (e)          (e)         |P=0.362      P=0.506N     P=0.494      P=0.530      | 
|POLY 6             |     P=0.550N     P=0.514      (e)          (e)         |P=0.352      P=0.497N     P=0.484      P=0.526      | 
|LOGISTIC REGRESSION|     (e)          P=0.505      (e)          (e)         |P=0.340      P=0.541N     P=0.415      P=0.520      | 
|COCH-ARM / FISHERS |     P=0.561N     P=0.500      (e)          (e)         |P=0.383      P=0.511N     P=0.524      P=0.547      | 
|ORDER RESTRICTED   |     P=0.387N     (e)          (e)          (e)         |P=0.436      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Rhabdomyosarcoma                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      1/44.40     |0/43.63      1/46.10      1/42.33      2/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |0.0%         2.2%         2.4%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    1/31 (3%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          535         |---          461          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      (e)          (e)          P=0.500     |P=0.150      P=0.508      P=0.470      P=0.232      | 
|POLY 3             |     P=0.195      (e)          (e)          P=0.499     |P=0.149      P=0.511      P=0.494      P=0.236      | 
|POLY 1.5           |     P=0.197      (e)          (e)          P=0.500     |P=0.150      P=0.507      P=0.494      P=0.235      | 
|POLY 6             |     P=0.192      (e)          (e)          P=0.498     |P=0.149      P=0.516      P=0.493      P=0.237      | 
|LOGISTIC REGRESSION|     P=0.246      (e)          (e)          P=0.513     |P=0.156      P=0.312      P=0.470      P=0.232      | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.119      (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      1/46.48      0/43.80     |0/43.63      1/46.01      0/42.33      3/43.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |0.0%         2.2%         0.0%         6.9%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          513          ---          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.515      (e)         |P=0.043 *    P=0.500      (e)          P=0.118      | 
|POLY 3             |     P=0.677      (e)          P=0.508      (e)         |P=0.041 *    P=0.511      (e)          P=0.118      | 
|POLY 1.5           |     P=0.684      (e)          P=0.506      (e)         |P=0.042 *    P=0.507      (e)          P=0.117      | 
|POLY 6             |     P=0.666      (e)          P=0.511      (e)         |P=0.041 *    P=0.515      (e)          P=0.119      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      (e)         |P=0.045 *    P=0.371      (e)          P=0.120      | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.044 *    P=0.500      (e)          P=0.121      | 
|ORDER RESTRICTED   |     P=0.389      (e)          (e)          (e)         |P=0.020 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/43.63      1/46.01      0/42.33      2/43.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          513          ---          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.135      P=0.500      (e)          P=0.234      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.137      P=0.511      (e)          P=0.236      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.137      P=0.507      (e)          P=0.236      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.138      P=0.515      (e)          P=0.238      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.144      P=0.371      (e)          P=0.237      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.140      P=0.500      (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.074      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      1/46.48      0/43.80     |0/43.63      1/46.01      0/42.33      3/43.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |0.0%         2.2%         0.0%         6.9%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          513          ---          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.515      (e)         |P=0.043 *    P=0.500      (e)          P=0.118      | 
|POLY 3             |     P=0.677      (e)          P=0.508      (e)         |P=0.041 *    P=0.511      (e)          P=0.118      | 
|POLY 1.5           |     P=0.684      (e)          P=0.506      (e)         |P=0.042 *    P=0.507      (e)          P=0.117      | 
|POLY 6             |     P=0.666      (e)          P=0.511      (e)         |P=0.041 *    P=0.515      (e)          P=0.119      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      (e)         |P=0.045 *    P=0.371      (e)          P=0.120      | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.044 *    P=0.500      (e)          P=0.121      | 
|ORDER RESTRICTED   |     P=0.389      (e)          (e)          (e)         |P=0.020 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |3/44.09      1/45.90      0/42.33      1/43.57      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.8%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |2/36 (6%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |591          561          ---          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.211N     P=0.317N     P=0.144N     P=0.310N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.207N     P=0.291N     P=0.126N     P=0.309N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.206N     P=0.296N     P=0.125N     P=0.309N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.210N     P=0.285N     P=0.127N     P=0.308N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.192N     P=0.337N     P=0.121N     P=0.305N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.309N     P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.085N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/49 (4%)    1/48 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      1/46.72      0/43.80     |2/44.00      1/44.82      1/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         0.0%        |4.6%         2.2%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |1/36 (3%)    0/35 (0%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          667          ---         |606          674          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.690      (e)          P=0.529      (e)         |P=0.159N     P=0.484N     P=0.535N     P=0.240N     | 
|POLY 3             |     P=0.675      (e)          P=0.512      (e)         |P=0.159N     P=0.494N     P=0.516N     P=0.240N     | 
|POLY 1.5           |     P=0.684      (e)          P=0.511      (e)         |P=0.157N     P=0.500N     P=0.515N     P=0.239N     | 
|POLY 6             |     P=0.662      (e)          P=0.515      (e)         |P=0.161N     P=0.485N     P=0.518N     P=0.240N     | 
|LOGISTIC REGRESSION|     P=0.721      (e)          P=0.492      (e)         |P=0.147N     P=0.535N     P=0.504N     P=0.221N     | 
|COCH-ARM / FISHERS |     P=0.699      (e)          P=0.510      (e)         |P=0.149N     P=0.508N     P=0.500N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.392      (e)          (e)          (e)         |P=0.120N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      2/46.48      2/44.19     |0/43.63      1/45.35      3/42.84      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         4.5%        |0.0%         2.2%         7.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    1/33 (3%)   |0/36 (0%)    1/35 (3%)    2/31 (7%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      618         |---          729 (T)      574          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.067      (e)          P=0.255      P=0.222     |P=0.341      P=0.494      P=0.102      P=0.494      | 
|POLY 3             |     P=0.080      (e)          P=0.246      P=0.235     |P=0.343      P=0.508      P=0.115      P=0.499      | 
|POLY 1.5           |     P=0.082      (e)          P=0.243      P=0.236     |P=0.344      P=0.505      P=0.114      P=0.498      | 
|POLY 6             |     P=0.076      (e)          P=0.250      P=0.233     |P=0.344      P=0.511      P=0.116      P=0.500      | 
|LOGISTIC REGRESSION|     P=0.085      (e)          P=0.255      P=0.240     |P=0.347      P=0.494      P=0.120      P=0.494      | 
|COCH-ARM / FISHERS |     P=0.086      (e)          P=0.247      P=0.247     |P=0.351      P=0.500      P=0.121      P=0.500      | 
|ORDER RESTRICTED   |     P=0.114      (e)          (e)          (e)         |P=0.150      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      2/46.48      2/44.19     |0/43.63      0/45.35      2/42.84      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         4.5%        |0.0%         0.0%         4.7%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      618         |---          ---          574          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.067      (e)          P=0.255      P=0.222     |P=0.241      (e)          P=0.216      P=0.494      | 
|POLY 3             |     P=0.080      (e)          P=0.246      P=0.235     |P=0.239      (e)          P=0.233      P=0.499      | 
|POLY 1.5           |     P=0.082      (e)          P=0.243      P=0.236     |P=0.240      (e)          P=0.232      P=0.498      | 
|POLY 6             |     P=0.076      (e)          P=0.250      P=0.233     |P=0.239      (e)          P=0.234      P=0.500      | 
|LOGISTIC REGRESSION|     P=0.085      (e)          P=0.255      P=0.240     |P=0.247      (e)          P=0.244      P=0.494      | 
|COCH-ARM / FISHERS |     P=0.086      (e)          P=0.247      P=0.247     |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.114      (e)          (e)          (e)         |P=0.164      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.60      2/47.28      0/46.48      0/43.80     |0/43.63      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    2/41 (5%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.434N     P=0.255      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.396N     P=0.250      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.399N     P=0.245      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.394N     P=0.257      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.255      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.262N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 21      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      2/43.80     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |                                                    | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    2/33 (6%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    (e)          (e)          P=0.208     |                                                    | 
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.233     |                                                    | 
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.235     |                                                    | 
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.230     |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.208     |                                                    | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.028 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |1/43.63      0/45.35      0/42.33      3/43.40      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         0.0%         0.0%         6.9%         | 
|TERMINAL (d)       |                                                        |1/36 (3%)    0/35 (0%)    0/31 (0%)    3/35 (9%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.085      P=0.506N     P=0.530N     P=0.295      | 
|POLY 3             |                                                        |P=0.081      P=0.492N     P=0.506N     P=0.303      | 
|POLY 1.5           |                                                        |P=0.082      P=0.495N     P=0.506N     P=0.302      | 
|POLY 6             |                                                        |P=0.080      P=0.489N     P=0.507N     P=0.305      | 
|LOGISTIC REGRESSION|                                                        |P=0.085      (e)          (e)          P=0.295      | 
|COCH-ARM / FISHERS |                                                        |P=0.086      P=0.500N     P=0.500N     P=0.309      | 
|ORDER RESTRICTED   |                                                        |P=0.037 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 22      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      1/46.48      0/43.80     |2/43.63      1/45.35      1/42.33      1/43.79      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |4.6%         2.2%         2.4%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |2/36 (6%)    1/35 (3%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      729 (T)      729 (T)      618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.515      (e)         |P=0.418N     P=0.510N     P=0.552N     P=0.501N     | 
|POLY 3             |     P=0.677      (e)          P=0.508      (e)         |P=0.416N     P=0.486N     P=0.511N     P=0.499N     | 
|POLY 1.5           |     P=0.684      (e)          P=0.506      (e)         |P=0.416N     P=0.491N     P=0.511N     P=0.501N     | 
|POLY 6             |     P=0.666      (e)          P=0.511      (e)         |P=0.416N     P=0.480N     P=0.512N     P=0.495N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      (e)         |P=0.415N     P=0.510N     P=0.552N     P=0.501N     | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.409N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.389      (e)          (e)          (e)         |P=0.412N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |3/50 (6%)    4/50 (8%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.60      2/47.28      2/46.72      2/43.80     |3/44.05      4/45.56      2/42.58      1/43.40      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         4.3%         4.6%        |6.8%         8.8%         4.7%         2.3%         | 
|TERMINAL (d)       |     1/38 (3%)    2/41 (5%)    1/41 (2%)    2/33 (6%)   |2/36 (6%)    3/35 (9%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      667          729 (T)     |606          674          662          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.363      P=0.527      P=0.534      P=0.451     |P=0.173N     P=0.502      P=0.540N     P=0.312N     | 
|POLY 3             |     P=0.409      P=0.520      P=0.516      P=0.494     |P=0.170N     P=0.518      P=0.515N     P=0.310N     | 
|POLY 1.5           |     P=0.415      P=0.512      P=0.511      P=0.497     |P=0.169N     P=0.512      P=0.515N     P=0.310N     | 
|POLY 6             |     P=0.399      P=0.530      P=0.522      P=0.489     |P=0.171N     P=0.527      P=0.517N     P=0.310N     | 
|LOGISTIC REGRESSION|     P=0.399      P=0.527      P=0.508      P=0.451     |P=0.167N     P=0.512      P=0.508N     P=0.307N     | 
|COCH-ARM / FISHERS |     P=0.423      P=0.500      P=0.500      P=0.500     |P=0.162N     P=0.500      P=0.500N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.457      (e)          (e)          (e)         |P=0.211N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 23      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |5/50 (10%)   5/50 (10%)   3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.60      2/47.28      3/46.72      2/43.80     |5/44.05      5/45.56      3/42.58      2/43.79      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         6.4%         4.6%        |11.4%        11.0%        7.1%         4.6%         | 
|TERMINAL (d)       |     1/38 (3%)    2/41 (5%)    2/41 (5%)    2/33 (6%)   |4/36 (11%)   4/35 (11%)   2/31 (7%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      667          729 (T)     |606          674          662          618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.339      P=0.527      P=0.340      P=0.451     |P=0.141N     P=0.626      P=0.420N     P=0.224N     | 
|POLY 3             |     P=0.386      P=0.520      P=0.322      P=0.494     |P=0.134N     P=0.609N     P=0.375N     P=0.218N     | 
|POLY 1.5           |     P=0.394      P=0.512      P=0.316      P=0.497     |P=0.134N     P=0.616N     P=0.374N     P=0.219N     | 
|POLY 6             |     P=0.374      P=0.530      P=0.329      P=0.489     |P=0.134N     P=0.599N     P=0.377N     P=0.215N     | 
|LOGISTIC REGRESSION|     P=0.376      P=0.527      P=0.318      P=0.451     |P=0.134N     P=0.607N     P=0.372N     P=0.218N     | 
|COCH-ARM / FISHERS |     P=0.404      P=0.500      P=0.309      P=0.500     |P=0.128N     P=0.630N     P=0.357N     P=0.218N     | 
|ORDER RESTRICTED   |     P=0.365      (e)          (e)          (e)         |P=0.201N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.86      0/47.28      2/46.48      3/44.39     |0/43.63      1/45.35      4/43.11      2/44.00      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.3%         6.8%        |0.0%         2.2%         9.3%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    1/33 (3%)   |0/36 (0%)    1/35 (3%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     661          ---          729 (T)      595         |---          729 (T)      503          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.083      P=0.477N     P=0.528      P=0.287     |P=0.159      P=0.494      P=0.059      P=0.234      | 
|POLY 3             |     P=0.097      P=0.489N     P=0.512      P=0.301     |P=0.163      P=0.508      P=0.058      P=0.239      | 
|POLY 1.5           |     P=0.099      P=0.493N     P=0.509      P=0.303     |P=0.161      P=0.505      P=0.058      P=0.237      | 
|POLY 6             |     P=0.093      P=0.485N     P=0.516      P=0.298     |P=0.165      P=0.511      P=0.059      P=0.242      | 
|LOGISTIC REGRESSION|     P=0.109      P=0.531N     P=0.506      P=0.309     |P=0.169      P=0.494      P=0.064      P=0.247      | 
|COCH-ARM / FISHERS |     P=0.104      P=0.500N     P=0.500      P=0.309     |P=0.165      P=0.500      P=0.059      P=0.247      | 
|ORDER RESTRICTED   |     P=0.104      (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 24      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |23/50 (46%)  19/50 (38%)  28/50 (56%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     3/45.53      1/47.28      0/46.48      3/44.19     |23/45.56     19/46.35     28/43.89     27/45.42     | 
|POLY-3 PERCENT (g) |     6.6%         2.1%         0.0%         6.8%        |50.5%        41.0%        63.8%        59.5%        | 
|TERMINAL (d)       |     2/38 (5%)    1/41 (2%)    0/41 (0%)    2/33 (6%)   |19/36 (53%)  16/35 (46%)  23/31 (74%)  22/35 (63%)  | 
|FIRST INCIDENCE    |     301          729 (T)      ---          616         |440          492          503          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.480      P=0.287N     P=0.114N     P=0.616     |P=0.094      P=0.296N     P=0.073      P=0.250      | 
|POLY 3             |     P=0.514      P=0.292N     P=0.115N     P=0.649     |P=0.089      P=0.238N     P=0.138      P=0.254      | 
|POLY 1.5           |     P=0.519      P=0.298N     P=0.117N     P=0.653     |P=0.093      P=0.249N     P=0.149      P=0.253      | 
|POLY 6             |     P=0.508      P=0.283N     P=0.113N     P=0.644     |P=0.089      P=0.224N     P=0.126      P=0.264      | 
|LOGISTIC REGRESSION|     P=0.555      P=0.406N     P=0.196N     P=0.653N    |P=0.095      P=0.232N     P=0.161      P=0.259      | 
|COCH-ARM / FISHERS |     P=0.526      P=0.309N     P=0.121N     P=0.661N    |P=0.121      P=0.272N     P=0.212      P=0.274      | 
|ORDER RESTRICTED   |     P=0.268      (e)          (e)          (e)         |P=0.089      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/43.63      1/45.39      1/42.71      2/44.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.3%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          719          622          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.247      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.156      P=0.508      P=0.496      P=0.242      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.239      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.512      P=0.496      P=0.246      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.167      P=0.511      P=0.520      P=0.273      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 25      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/43.63      1/45.39      1/42.71      2/44.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.3%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          719          622          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.247      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.156      P=0.508      P=0.496      P=0.242      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.239      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.512      P=0.496      P=0.246      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.167      P=0.511      P=0.520      P=0.273      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  38/50 (76%)  37/50 (74%)  34/50 (68%) |38/50 (76%)  27/50 (54%)  33/50 (66%)  31/50 (62%)  | 
|POLY-3 RATE (b)    |     34/48.07     38/47.86     37/48.25     34/46.91    |38/46.54     27/46.09     33/44.32     31/45.66     | 
|POLY-3 PERCENT (g) |     70.7%        79.4%        76.7%        72.5%       |81.6%        58.6%        74.5%        67.9%        | 
|TERMINAL (d)       |     27/38 (71%)  35/41 (85%)  32/41 (78%)  24/33 (73%) |31/36 (86%)  22/35 (63%)  24/31 (77%)  25/35 (71%)  | 
|FIRST INCIDENCE    |     484          604          543          535         |524          673          574          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.243      P=0.472      P=0.541      P=0.314     |P=0.307N     P=0.028N*    P=0.527N     P=0.144N     | 
|POLY 3             |     P=0.528N     P=0.223      P=0.330      P=0.515     |P=0.234N     P=0.010N*    P=0.273N     P=0.090N     | 
|POLY 1.5           |     P=0.499N     P=0.239      P=0.339      P=0.541     |P=0.238N     P=0.011N*    P=0.263N     P=0.094N     | 
|POLY 6             |     P=0.538      P=0.207      P=0.317      P=0.492     |P=0.231N     P=0.009N**   P=0.293N     P=0.085N     | 
|LOGISTIC REGRESSION|     P=0.509N     P=0.343      P=0.382      P=0.569     |P=0.253N     P=0.006N**   P=0.234N     P=0.094N     | 
|COCH-ARM / FISHERS |     P=0.447N     P=0.252      P=0.330      P=0.585N    |P=0.219N     P=0.018N*    P=0.189N     P=0.097N     | 
|ORDER RESTRICTED   |     P=0.419      (e)          (e)          (e)         |P=0.075N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 26      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  22/50 (44%)  30/50 (60%)  27/50 (54%) |33/50 (66%)  38/50 (76%)  41/50 (82%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |     29/49.08     22/49.00     30/50.00     27/47.63    |33/47.24     38/49.43     41/46.20     41/48.78     | 
|POLY-3 PERCENT (g) |     59.1%        44.9%        60.0%        56.7%       |69.9%        76.9%        88.8%        84.1%        | 
|TERMINAL (d)       |     19/38 (50%)  17/41 (42%)  21/41 (51%)  14/33 (42%) |24/36 (67%)  24/35 (69%)  27/31 (87%)  29/35 (83%)  | 
|FIRST INCIDENCE    |     301          431          543          535         |440          461          503          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.290      P=0.088N     P=0.496N     P=0.526     |P=0.081      P=0.253      P=0.031 *    P=0.097      | 
|POLY 3             |     P=0.435      P=0.113N     P=0.544      P=0.487N    |P=0.041 *    P=0.289      P=0.018 *    P=0.073      | 
|POLY 1.5           |     P=0.451      P=0.114N     P=0.526      P=0.470N    |P=0.040 *    P=0.252      P=0.019 *    P=0.066      | 
|POLY 6             |     P=0.428      P=0.113N     P=0.568      P=0.498N    |P=0.043 *    P=0.334      P=0.018 *    P=0.081      | 
|LOGISTIC REGRESSION|     P=0.525N     P=0.175N     P=0.400      P=0.405N    |P=0.033 *    P=0.197      P=0.028 *    P=0.053      | 
|COCH-ARM / FISHERS |     P=0.500      P=0.115N     P=0.500      P=0.420N    |P=0.043 *    P=0.189      P=0.055      P=0.055      | 
|ORDER RESTRICTED   |     P=0.419      (e)          (e)          (e)         |P=0.025 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  45/50 (90%)  47/50 (94%)  45/50 (90%) |47/50 (94%)  45/50 (90%)  46/50 (92%)  47/50 (94%)  | 
|POLY-3 RATE (b)    |     45/49.62     45/49.46     47/50.00     45/48.32    |47/49.05     45/49.43     46/46.71     47/49.24     | 
|POLY-3 PERCENT (g) |     90.7%        91.0%        94.0%        93.1%       |95.8%        91.0%        98.5%        95.4%        | 
|TERMINAL (d)       |     34/38 (90%)  38/41 (93%)  38/41 (93%)  30/33 (91%) |34/36 (94%)  31/35 (89%)  31/31 (100%) 33/35 (94%)  | 
|FIRST INCIDENCE    |     301          431          543          535         |440          461          503          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.312N     P=0.478N     P=0.252     |P=0.384      P=0.453N     P=0.276      P=0.514      | 
|POLY 3             |     P=0.355      P=0.618      P=0.402      P=0.470     |P=0.439      P=0.288N     P=0.427      P=0.659N     | 
|POLY 1.5           |     P=0.392      P=0.622      P=0.381      P=0.508     |P=0.459      P=0.286N     P=0.512      P=0.642N     | 
|POLY 6             |     P=0.356      P=0.615      P=0.434      P=0.467     |P=0.414      P=0.312N     P=0.315      P=0.684N     | 
|LOGISTIC REGRESSION|     P=0.504      P=0.630N     P=0.332      P=0.618     |P=0.369      P=0.300N     P=0.660      P=0.632      | 
|COCH-ARM / FISHERS |     P=0.533      P=0.630N     P=0.357      P=0.630N    |P=0.482      P=0.357N     P=0.500N     P=0.661N     | 
|ORDER RESTRICTED   |     P=0.465      (e)          (e)          (e)         |P=0.311      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    

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