National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5753

TDMS Study 96010-04 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:45:09       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:45:09       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
                                                                                                                                   
                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 0 MG/L                                   |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      301   484   561   561   562   603   623   625   638   661                 |                                                 
 |      663   699                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 500 MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 0    TERMINAL 41        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      431   574   577   604   668   698   713   721   722                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 1000MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 0    TERMINAL 41        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      543   558   562   570   607   667   668   672   673                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 2000MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      288   465   535   570   595   605   616   618   640   640                 |                                                 
 |      652   657   664   694   711   719   721                                   |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |0 MG/L     |   100.0 100.0 100.0  98.0  98.0  96.0  96.0  88.0  78.0  76.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |500 MG/L   |   100.0 100.0 100.0 100.0 100.0  98.0  98.0  92.0  92.0  82.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1000MG/L   |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  92.0  90.0  82.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |2000MG/L   |   100.0 100.0 100.0  98.0  98.0  96.0  94.0  88.0  74.0  66.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                0 MG/L       500 MG/L     1000MG/L     2000MG/L |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       76.0%        82.0%        82.0%        66.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.192      P=0.538N     P=0.577N     P=0.423  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       581.8        634.2        613.3        611.2    |                                                 
 |NATURAL DEATHS (C)      |       (30.6)       (32.4)       (18.8)       (25.9)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       693.7        711.9        708.2        688.9    |                                                 
 |(STANDARD ERROR)        |       (11.4)       ( 7.6)       ( 7.1)       (11.7)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 0 MG/L                                   |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 1    TERMINAL 36        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      440   524   576   588   591   591   597   606   630   639                 |                                                 
 |      660   674   710                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      271                                                                       |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 500 MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      461   492   513   552   561   568   673   674   682   706                 |                                                 
 |      713   714   717   719   727                                               |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 1000MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 49     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 31        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      34    486   503   503   542   574   602   618   618   622                 |                                                 
 |      661   662   683   711   712   719   720   723                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 2000MG/L                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      142   447   455   475   535   540   597   618   646   667                 |                                                 
 |      681   685   685   688   705                                               |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |0 MG/L     |   100.0 100.0 100.0 100.0 100.0  98.0  95.9  85.7  77.6  73.5      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |500 MG/L   |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  88.0  88.0  70.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1000MG/L   |    98.0  98.0  98.0  98.0  98.0  98.0  89.8  85.7  75.5  63.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |2000MG/L   |   100.0  98.0  98.0  98.0  98.0  92.0  88.0  86.0  82.0  70.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                0 MG/L       500 MG/L     1000MG/L     2000MG/L |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       73.5%        70.0%        63.3%        70.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.728      P=0.937      P=0.426      P=0.871  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       602.0        631.5        594.1        571.1    |                                                 
 |NATURAL DEATHS (C)      |       (18.9)       (24.6)       (37.9)       (38.5)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       686.8        699.7        679.4        681.6    |                                                 
 |(STANDARD ERROR)        |       (12.6)       ( 9.6)       (16.6)       (15.3)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                           
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        0 MG/L           = 1                                                        
                                                        500 MG/L         = 2                                                        
                                                        1000MG/L         = 3                                                        
                                                        2000MG/L         = 4                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 1                                             41                    2                 3                                     
      |                                                                                                                             
      |                                               41                    2     4  1        3 3 2                                 
      |                                                                           4  1       4  3122                                
   95 +                                                                                                                             
      |                                                                                      4   332    2                           
P     |                                                                                           3   4 2         2                 
E     |                                                                                                                             
R  90 +                                                                                          1    4 1         2   2             
C     |                                                                                                                             
E     |                                                                                                 141           2 2           
N     |                                                                                                  411            22          
T  85 +                                                                                                                             
      |                                                                                                   41 1    33     22         
S     |                                                                                                      1   1 3      2 2       
U     |                                                                                                                             
R  80 +                                                                                                      4 4                    
V     |                                                                                                                             
I     |                                                                                                          1    1             
V     |                                                                                                        4 4    1     1       
A  75 +                                                                                                                             
L     |                                                                                                          4    4             
      |                                                                                                               4 4           
      |                                                                                                                             
   70 +                                                                                                                 44          
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                                  4  4       
   65 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 14 obs hidden.                                                                                                                
                                                                                                                                   
                                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                           
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        0 MG/L           = 1                                                        
                                                        500 MG/L         = 2                                                        
                                                        1000MG/L         = 3                                                        
                                                        2000MG/L         = 4                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 1     3                4                                             1   2                                                  
      |                                                                                                                             
      |       3                4                                             14  2   32    1                                        
      |                                                                       4 4    323 2 1       1                                
   95 +                                                                                                                             
      |                                                                         4  4     2     2   11                               
      |                                                                            4         4 2 2                                  
      |                                                                                3      3     1 1                             
P  90 +                                                                                      43  22                                 
E     |                                                                                                                             
R     |                                                                                       4   2   11           2                
C     |                                                                                                11 3                         
E  85 +                                                                                                                             
N     |                                                                                                 1 41  4    22               
T     |                                                                                                       4   4 2  2            
      |                                                                                                    1 1                      
S  80 +                                                                                                   3  1   14 4  22           
U     |                                                                                                                             
R     |                                                                                                          1 1                
V     |                                                                                                                 22          
I  75 +                                                                                                          3 13   1           
V     |                                                                                                             34  1   1       
A     |                                                                                                              4 4 22         
L     |                                                                                                                             
   70 +                                                                                                                4332 2       
      |                                                                                                                             
      |                                                                                                                             
      |                                                                                                                             
   65 +                                                                                                                  33         
      |                                                                                                                   3 3       
      |                                                                                                                             
      |                                                                                                                             
   60 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 15 obs hidden.                                                                                                                

--multipart-boundary
Content-type: text/plain
Range: bytes 51045-51045/51045


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.