National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6817

TDMS Study 97006-01 Pathology Tables

NTP  EXP/TEST: 97006-01                              METHYL ISOBUTYL KETONE                                       PAGE: 1
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 05/11/04
ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                                                            TIME: 08:44:53

                                                         EIS REPORT 03


       FACILITY:  Battelle Northwest

       NTP C#:  C97006

       CONTRACT NUMBER:  N01-ES-05452

       CAS NUMBER:  108-10-1

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97006-01                              METHYL ISOBUTYL KETONE                                       PAGE: 2
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 05/11/04
ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                      EISRPT03                                              TIME: 08:44:53
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 SPECIES-STRAIN: F 344-RATS                 SEX: FEMALE      WEEK ON DOSE: 105    FIRST DOSE: 05/25/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 CONTROL            50     93.5    5.9        35    362.9   32.9                     35    268.8   34.2

 450 PPM            50     92.2    5.8        33    361.3   35.2        99.5         33    268.7   33.8

 900 PPM            50     92.1    5.9        26    378.0   46.0       104.1         26    286.3   44.9

 1800 PPM           50     93.3    6.4        32    362.6   24.1        99.9         32    268.6   23.3




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 SPECIES-STRAIN: F 344-RATS                 SEX: MALE        WEEK ON DOSE: 105    FIRST DOSE: 05/25/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 CONTROL            50    104.1    9.7        32    521.0   47.5                     32    418.4   51.0

 450 PPM            50    103.5    9.1        28    511.9   71.1        98.2         28    409.3   71.3

 900 PPM            50    102.9    9.3        25    494.7   60.1        94.9         25    393.2   61.0

 1800 PPM           50    102.0    8.6        19    489.9   44.8        94.0         19    387.1   42.6

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