National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13084

TDMS Study 99033-02 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: BIORELIANCE                           TRANSGENIC MODEL EVALUATION II (ASPARTAME)                               DATE: 03/05/03  
EXPERIMENT: 99033 TEST: 02                                                                                        TIME: 13:37:05    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: DOSED FEED                                             NTP:  C99033      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                         FINAL #3/P53 MICE                                                          
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BIORELIANCE                                      TRANSGENIC MODEL EVALUATION II (ASPARTAME)                  DATE: 03/05/03    
EXPERIMENT: 99033 TEST: 02                                                                                        TIME: 13:46:34    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: 26                                       ROUTE: DOSED FEED                                             NTP:  C99033      
CONT: N01-ES-65406                                                                                                CAS: 22839-47-0   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                   26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                
==================================================================================================================================  
      VEHICLE CONTROL                 3125 PPM                           6250 PPM                         12500   PPM               
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.1    22.0       4.5     21.8    1.10      639      4.3     21.4    1.05     1242      4.0     20.9    0.98     2395       
  3     4.2    22.6       4.1     22.3    0.98      581      4.2     22.2    1.00     1195      4.0     21.6    0.95     2318       
  4     4.1    22.8       4.3     23.0    1.05      588      4.4     22.4    1.07     1218      4.1     22.5    1.00     2296       
  5     4.3    23.5       4.3     23.6    1.00      568      4.2     22.9    0.98     1151      4.1     22.9    0.95     2254       
  6     4.2    24.0       4.3     24.1    1.02      563      4.3     23.7    1.02     1130      3.9     23.4    0.93     2106       
  7     4.3    24.8       4.3     24.7    1.00      549      4.2     24.2    0.98     1074      4.0     23.9    0.93     2085       
  8     4.3    25.7       4.3     25.5    1.00      528      4.1     24.5    0.95     1045      4.1     24.6    0.95     2104       
  9     4.1    26.1       4.3     25.9    1.05      522      4.0     24.9    0.98     1013      3.9     24.9    0.95     1946       
 10     4.2    26.6       4.5     26.2    1.07      537      4.5     25.3    1.07     1120      3.9     25.6    0.93     1912       
 11     4.0    27.0       4.6     26.7    1.15      533      4.5     25.5    1.13     1110      4.1     26.0    1.03     1950       
 12     4.1    27.1       4.6     27.2    1.12      532      4.2     25.9    1.02     1014      4.3     26.5    1.05     2027       
 13     4.1    27.6       4.4     27.6    1.07      496      4.3     26.8    1.05     1010      4.0     26.8    0.98     1866       
 14     4.3    28.0       4.2     27.8    0.98      471      4.3     27.3    1.00      992      4.1     27.3    0.95     1864       
 15     4.2    28.3       4.4     28.2    1.05      492      4.5     27.4    1.07     1026      4.0     27.5    0.95     1814       
 16     4.4    28.6       4.4     28.4    1.00      480      4.0     27.0    0.91      931      4.1     28.1    0.93     1839       
 17     4.4    29.1       4.5     28.8    1.02      493      4.4     27.8    1.00      983      4.2     28.2    0.95     1869       
 18     4.3    29.4       4.5     29.2    1.05      480      4.2     28.7    0.98      924      4.4     28.9    1.02     1892       
 19     4.3    29.8       4.3     29.4    1.00      452      4.1     29.0    0.95      884      3.9     28.9    0.91     1692       
 20     4.2    30.1       4.1     29.3    0.98      441      4.1     29.1    0.98      875      3.8     28.8    0.90     1647       
 21     4.1    30.3       4.2     29.6    1.02      449      4.2     29.7    1.02      885      3.9     29.3    0.95     1671       
 22     4.0    30.0       4.3     29.5    1.08      455      4.1     29.5    1.03      861      4.1     29.6    1.03     1731       
 23     4.1    30.8       4.3     29.0    1.05      459      4.2     29.8    1.02      876      3.7     29.0    0.90     1596       
 24     4.1    30.6       4.3     29.6    1.05      451      4.2     29.8    1.02      883      3.7     29.0    0.90     1578       
 25     3.9    30.4       4.3     29.6    1.10      457      4.2     29.8    1.08      873      4.0     29.2    1.03     1693       
 26     4.1    30.9       4.4     30.0    1.07      453      4.2     29.7    1.02      873      4.0     29.5    0.98     1688       
 27     4.0    30.8       4.1     29.8    1.03      435      4.1     30.0    1.03      851      4.0     29.6    1.00     1694       
 28     4.3    31.0       4.2     29.9    0.98      435      4.0     29.9    0.93      829      3.9     29.7    0.91     1653       
 29     4.2    31.2       4.2     30.2    1.00      438      4.1     29.9    0.98      847      4.0     29.8    0.95     1673       
 30     4.5    31.8       4.4     30.6    0.98      454      4.3     29.8    0.96      896      4.2     30.2    0.93     1746       
 31     4.4    32.3       4.4     31.0    1.00      445      4.3     30.3    0.98      884      4.2     30.0    0.95     1752       
 32     4.5    32.6       4.3     31.0    0.96      434      4.3     30.6    0.96      868      4.1     29.9    0.91     1723       
 33     4.3    32.4       4.3     30.9    1.00      437      4.3     30.3    1.00      879      4.2     29.8    0.98     1745       
 34     4.3    32.3       4.3     30.6    1.00      443      4.5     30.5    1.05      917      4.1     29.9    0.95     1710       
 35     4.6    32.2       4.5     30.7    0.98      453      4.2     30.2    0.91      868      4.5     29.7    0.98     1907       
 36     4.4    32.4       4.4     30.9    1.00      445      4.2     30.1    0.95      875      4.2     29.9    0.95     1754       
 37     4.2    31.6       4.4     30.6    1.05      445      4.3     30.1    1.02      897      4.2     29.7    1.00     1761       
 38     4.3    31.9       4.4     30.9    1.02      447      4.4     30.1    1.02      905      4.1     29.3    0.95     1746       
 39     4.1    31.9       4.2     30.4    1.02      432      4.4     29.6    1.07      922      3.9     29.4    0.95     1653       
 40     4.2    31.3       4.3     30.3    1.02      448      4.3     29.7    1.02      911      4.5     29.8    1.07     1872       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.2    25.0       4.4     24.9    1.05      553      4.3     24.1    1.02     1110      4.0     24.1    0.97     2105       
SD(D)   0.1               0.1             0.05       38      0.2             0.05       81      0.1             0.04      175       
CV(E)   2.3               3.1             5.1       6.8      3.6             5.0       7.3      2.9             4.0       8.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.2    30.8       4.3     29.9    1.02      453      4.2     29.5    1.00      897      4.1     29.3    0.96     1739       
SD(D)   0.2               0.1             0.04       17      0.1             0.05       45      0.2             0.04       89       
CV(E)   4.0               2.5             3.5       3.7      3.2             4.6       5.0      5.0             4.5       5.1       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                    
         26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                          
=============================================================================                                                       
                  25000   PPM                        50000   PPM                                                                    
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  2     4.2     21.5     1.02    4832      3.9     21.4     0.95    9070                                                            
  3     4.1     21.8     0.98    4696      3.7     21.6     0.88    8475                                                            
  4     4.2     22.8     1.02    4655      3.8     22.5     0.93    8556                                                            
  5     4.3     23.3     1.00    4593      4.0     23.0     0.93    8662                                                            
  6     4.1     23.9     0.98    4241      4.0     23.3     0.95    8474                                                            
  7     4.1     24.6     0.95    4187      4.0     24.1     0.93    8223                                                            
  8     4.1     24.7     0.95    4120      4.1     24.5     0.95    8320                                                            
  9     4.2     25.4     1.02    4160      3.8     24.8     0.93    7634                                                            
 10     4.4     26.1     1.05    4268      4.0     25.5     0.95    7810                                                            
 11     4.1     26.6     1.03    3859      4.0     25.8     1.00    7796                                                            
 12     4.7     27.3     1.15    4266      4.5     26.5     1.10    8551                                                            
 13     4.3     27.3     1.05    3914      4.1     27.0     1.00    7562                                                            
 14     4.3     28.1     1.00    3865      4.1     27.5     0.95    7453                                                            
 15     4.1     28.1     0.98    3652      3.9     27.5     0.93    7061                                                            
 16     4.4     28.4     1.00    3887      4.2     27.8     0.95    7460                                                            
 17     4.5     29.0     1.02    3842      4.1     28.1     0.93    7288                                                            
 18     4.4     29.3     1.02    3713      4.3     28.7     1.00    7453                                                            
 19     4.1     29.4     0.95    3460      4.1     29.2     0.95    6937                                                            
 20     4.3     30.2     1.02    3559      3.9     29.5     0.93    6627                                                            
 21     4.2     30.4     1.02    3441      3.8     29.5     0.93    6350                                                            
 22     3.9     30.0     0.98    3240      3.8     29.0     0.95    6538                                                            
 23     3.9     29.9     0.95    3272      3.8     29.1     0.93    6500                                                            
 24     4.0     29.7     0.98    3404      3.8     29.1     0.93    6520                                                            
 25     3.8     29.2     0.97    3275      3.7     29.1     0.95    6276                                                            
 26     4.3     29.5     1.05    3658      4.0     29.3     0.98    6747                                                            
 27     4.0     29.6     1.00    3395      3.9     29.4     0.98    6667                                                            
 28     3.9     28.8     0.91    3357      3.9     29.7     0.91    6523                                                            
 29     4.1     29.0     0.98    3508      3.9     29.7     0.93    6613                                                            
 30     4.2     29.3     0.93    3578      4.1     29.7     0.91    6861                                                            
 31     4.2     29.4     0.95    3578      4.2     30.2     0.95    6970                                                            
 32     4.2     29.5     0.93    3541      4.0     30.3     0.89    6571                                                            
 33     4.3     29.7     1.00    3644      4.1     30.5     0.95    6674                                                            
 34     4.6     30.3     1.07    3811      4.0     30.2     0.93    6611                                                            
 35     4.3     30.1     0.93    3541      4.2     30.2     0.91    6964                                                            
 36     4.3     30.1     0.98    3533      4.1     30.1     0.93    6869                                                            
 37     4.0     29.7     0.95    3383      4.0     30.1     0.95    6654                                                            
 38     4.3     29.9     1.00    3583      4.2     30.0     0.98    6971                                                            
 39     4.4     30.1     1.07    3642      4.1     29.9     1.00    6798                                                            
 40     4.3     30.1     1.02    3526      4.1     29.9     0.98    6790                                                            
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.2     24.6     1.02    4316      4.0     24.2     0.96    8261                                                            
SD(D)   0.2              0.05     311      0.2              0.05     465                                                            
CV(E)   4.2              5.2      7.2      5.3              5.7      5.6                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.2     29.5     0.99    3551      4.0     29.4     0.94    6805                                                            
SD(D)   0.2              0.04     177      0.2              0.03     323                                                            
CV(E)   4.7              4.3      5.0      3.9              2.9      4.7                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                   26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                
==================================================================================================================================  
      VEHICLE CONTROL                 3125 PPM                           6250 PPM                         12500   PPM               
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     3.9    18.5       4.1     18.1     1.05     706      4.0     18.2     1.03    1378      4.2     18.1     1.08    2898       
  3     4.4    19.6       4.3     19.2     0.98     695      4.0     18.9     0.91    1313      4.1     18.7     0.93    2724       
  4     4.7    20.0       4.8     20.2     1.02     737      4.5     19.9     0.96    1407      4.7     19.9     1.00    2938       
  5     4.9    20.8       4.7     20.5     0.96     714      4.7     20.5     0.96    1444      4.8     20.3     0.98    2991       
  6     4.8    21.0       4.7     20.5     0.98     722      4.8     21.2     1.00    1404      4.6     20.6     0.96    2798       
  7     5.2    20.7       4.7     20.7     0.90     707      4.8     20.5     0.92    1465      4.9     20.6     0.94    2950       
  8     5.0    21.5       4.5     20.9     0.90     676      5.0     21.4     1.00    1451      4.8     21.3     0.96    2827       
  9     4.8    21.7       4.7     21.5     0.98     689      5.0     22.0     1.04    1414      5.0     21.4     1.04    2934       
 10     5.3    22.1       5.0     21.8     0.94     714      4.9     22.0     0.92    1380      4.8     22.2     0.91    2699       
 11     5.6    22.1       4.8     22.0     0.86     687      5.3     22.4     0.95    1474      5.1     22.3     0.91    2830       
 12     5.1    22.0       4.8     22.0     0.94     682      4.4     22.6     0.86    1222      5.1     22.5     1.00    2828       
 13     5.1    22.2       4.9     22.6     0.96     683      4.7     23.4     0.92    1261      4.7     22.5     0.92    2635       
 14     4.5    22.6       4.4     23.0     0.98     592      4.2     23.5     0.93    1106      4.5     22.9     1.00    2448       
 15     4.3    22.9       4.6     23.2     1.07     621      4.3     23.9     1.00    1134      4.2     22.9     0.98    2267       
 16     4.7    22.7       5.0     23.3     1.06     670      4.4     24.0     0.94    1146      5.1     23.3     1.09    2735       
 17     4.9    23.1       4.8     23.4     0.98     640      4.9     24.0     1.00    1272      4.7     23.6     0.96    2493       
 18     4.9    23.3       4.8     23.4     0.98     640      4.5     24.4     0.92    1153      5.6     24.4     1.14    2852       
 19     4.6    23.6       4.5     23.5     0.98     598      4.3     24.8     0.93    1074      4.8     24.6     1.04    2440       
 20     4.6    23.7       4.3     23.8     0.93     569      4.2     24.8     0.91    1051      4.5     25.1     0.98    2227       
 21     4.0    23.7       4.2     23.5     1.05     563      4.3     25.1     1.08    1080      4.4     25.1     1.10    2195       
 22     4.9    24.1       4.4     23.7     0.90     584      4.6     25.0     0.94    1139      4.9     25.1     1.00    2436       
 23     4.8    24.0       4.7     23.4     0.98     623      4.7     25.3     0.98    1164      4.3     24.9     0.90    2165       
 24     4.8    24.2       4.7     23.8     0.98     613      4.5     25.5     0.94    1112      4.5     24.7     0.94    2295       
 25     4.8    24.2       4.7     23.6     0.98     617      4.6     25.4     0.96    1120      4.7     24.7     0.98    2382       
 26     4.5    24.3       4.6     23.7     1.02     607      4.8     25.7     1.07    1156      4.8     25.1     1.07    2418       
 27     4.7    23.9       4.3     23.4     0.91     579      4.5     25.7     0.96    1090      4.4     25.1     0.94    2218       
 28     4.9    24.5       4.4     23.4     0.90     590      4.6     25.8     0.94    1109      4.8     25.1     0.98    2376       
 29     4.6    24.2       4.6     23.4     1.00     616      4.7     25.8     1.02    1144      4.7     25.1     1.02    2340       
 30     4.7    25.0       4.5     24.1     0.96     579      4.5     25.5     0.96    1102      4.6     25.8     0.98    2238       
 31     4.4    25.2       4.3     24.1     0.98     555      4.4     25.7     1.00    1068      4.4     26.0     1.00    2115       
 32     4.4    25.3       4.4     24.4     1.00     559      4.3     25.8     0.98    1033      4.4     25.8     1.00    2141       
 33     4.7    24.9       4.4     24.0     0.94     572      4.5     25.8     0.96    1093      4.7     25.9     1.00    2252       
 34     4.6    25.2       4.6     24.5     1.00     589      4.3     25.9     0.93    1032      4.4     25.9     0.96    2133       
 35     4.8    25.2       4.5     24.7     0.94     564      6.8     25.8     1.42    1650      5.3     25.8     1.10    2572       
 36     4.6    25.4       4.5     24.7     0.98     569      4.7     26.4     1.02    1117      4.4     26.0     0.96    2131       
 37     4.7    25.3       4.5     24.6     0.96     567      4.5     26.3     0.96    1074      4.8     26.0     1.02    2291       
 38     4.9    25.7       4.5     24.4     0.92     580      4.8     26.6     0.98    1135      4.9     26.0     1.00    2336       
 39     4.4    25.7       4.6     24.4     1.05     585      4.5     26.5     1.02    1066      4.4     25.8     1.00    2134       
 40     4.7    26.1       4.5     24.3     0.96     580      4.6     26.2     0.98    1086      4.6     25.4     0.98    2252       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.9    21.0       4.7     20.8     0.96     701      4.7     21.1     0.96    1384      4.7     20.9     0.97    2838       
SD(D)   0.4               0.3              0.05      19      0.4              0.05      80      0.3              0.05     111       
CV(E)   8.6               5.6              5.5      2.7      8.2              5.5      5.8      6.7              5.5      3.9       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.6    24.4       4.5     23.8     0.98     593      4.6     25.4     0.99    1130      4.7     25.0     1.00    2329       
SD(D)   0.2               0.2              0.05      29      0.5              0.10     115      0.3              0.06     182       
CV(E)   4.6               3.8              4.7      4.8     10.6              9.6     10.2      6.6              5.6      7.8       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                  
         26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                          
=============================================================================                                                       
                  25000   PPM                        50000   PPM                                                                    
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  2     4.1     18.2     1.05    5686      3.8     17.7     0.97   10687                                                            
  3     4.2     19.0     0.95    5551      4.0     18.6     0.91   10601                                                            
  4     4.4     20.1     0.94    5428      4.0     19.3     0.85   10387                                                            
  5     4.5     20.1     0.92    5589      4.2     19.9     0.86   10482                                                            
  6     4.4     20.6     0.92    5344      4.3     20.3     0.90   10630                                                            
  7     4.7     20.8     0.90    5670      4.6     19.9     0.88   11459                                                            
  8     4.5     21.0     0.90    5347      4.5     21.3     0.90   10536                                                            
  9     4.9     21.7     1.02    5581      4.3     21.3     0.90    9994                                                            
 10     4.9     21.7     0.92    5648      3.9     21.9     0.74    8969                                                            
 11     5.1     22.2     0.91    5702      4.6     21.8     0.82   10565                                                            
 12     4.6     22.3     0.90    5157      4.8     21.9     0.94   10939                                                            
 13     4.8     22.5     0.94    5349      4.6     22.3     0.90   10385                                                            
 14     4.6     22.9     1.02    5026      4.3     22.6     0.96    9436                                                            
 15     5.1     23.6     1.19    5416      4.6     22.9     1.07   10064                                                            
 16     4.7     23.4     1.00    4989      5.0     23.1     1.06   10709                                                            
 17     4.7     22.9     0.96    5080      4.0     23.0     0.82    8713                                                            
 18     4.8     23.3     0.98    5140      4.8     23.5     0.98   10290                                                            
 19     4.6     23.6     1.00    4891      4.6     23.6     1.00    9754                                                            
 20     4.4     23.8     0.96    4643      4.5     24.1     0.98    9340                                                            
 21     4.3     24.0     1.08    4473      4.3     24.3     1.08    8764                                                            
 22     4.5     23.7     0.92    4702      4.3     24.0     0.88    8868                                                            
 23     4.7     23.7     0.98    4915      4.1     23.6     0.85    8710                                                            
 24     4.5     23.8     0.94    4686      4.6     24.2     0.96    9482                                                            
 25     4.6     23.5     0.96    4888      4.4     24.1     0.92    9102                                                            
 26     4.8     24.3     1.07    4956      4.5     24.4     1.00    9152                                                            
 27     4.4     24.0     0.94    4540      4.5     24.2     0.96    9354                                                            
 28     4.6     23.9     0.94    4761      4.5     24.3     0.92    9267                                                            
 29     4.5     24.0     0.98    4676      4.3     24.4     0.93    8775                                                            
 30     4.7     24.2     1.00    4851      4.2     24.3     0.89    8690                                                            
 31     4.6     24.5     1.05    4712      4.3     24.7     0.98    8720                                                            
 32     4.2     24.3     0.95    4273      4.5     24.6     1.02    9187                                                            
 33     4.7     24.5     1.00    4795      4.6     25.0     0.98    9121                                                            
 34     4.5     24.9     0.98    4525      4.5     24.6     0.98    9199                                                            
 35     5.1     24.9     1.06    5113      4.6     24.5     0.96    9396                                                            
 36     4.5     25.1     0.98    4444      4.3     24.9     0.93    8708                                                            
 37     4.6     25.0     0.98    4578      4.3     24.8     0.91    8746                                                            
 38     4.8     25.4     0.98    4719      4.5     25.1     0.92    9009                                                            
 39     4.9     25.4     1.11    4844      4.5     25.0     1.02    8939                                                            
 40     4.7     25.3     1.00    4617      4.7     25.1     1.00    9338                                                            
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.6     20.9     0.94    5504      4.3     20.5     0.88   10469                                                            
SD(D)   0.3              0.05     175      0.3              0.06     587                                                            
CV(E)   6.2              5.1      3.2      7.7              6.9      5.6                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.6     24.2     1.00    4787      4.5     24.2     0.96    9216                                                            
SD(D)   0.2              0.06     250      0.2              0.06     510                                                            
CV(E)   4.7              6.0      5.2      4.7              6.5      5.5                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                 
                                  26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                 
==================================================================================================================================  
      VEHICLE CONTROL              3125 PPM                 6250 PPM               12500   PPM              25000   PPM             
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               20.9  15                 20.3  15                 20.1  15                 20.1  15                 20.2  15      
  1               20.9  15                 20.3  15                 20.1  15                 20.1  15                 20.2  15      
  2   4.1  2520   22.0  15     4.5  2490   21.8  15     4.3  2490   21.4  15     4.0  2505   20.9  15     4.2  2505   21.5  15      
  3   4.2  2520   22.6  15     4.1  2520   22.3  15     4.2  2520   22.2  15     4.0  2535   21.6  15     4.1  2532   21.8  15      
  4   4.1  2535   22.8  15     4.3  2535   23.0  15     4.4  2535   22.4  15     4.1  2520   22.5  15     4.2  2520   22.8  15      
  5   4.3  2520   23.5  15     4.3  2520   23.6  15     4.2  2520   22.9  15     4.1  2535   22.9  15     4.3  2505   23.3  15      
  6   4.2  2505   24.0  15     4.3  2535   24.1  15     4.3  2535   23.7  15     3.9  2521   23.4  15     4.1  2520   23.9  15      
  7   4.3  2540   24.8  15     4.3  2520   24.7  15     4.2  2520   24.2  15     4.0  2534   23.9  15     4.1  2520   24.6  15      
  8   4.3  2520   25.7  15     4.3  2520   25.5  15     4.1  2520   24.5  15     4.1  2506   24.6  15     4.1  2352   24.7  14      
  9   4.1  2517   26.1  15     4.3  2510   25.9  15     4.0  2508   24.9  15     3.9  2503   24.9  15     4.2  2338   25.4  14      
 10   4.2  2505   26.6  15     4.5  2491   26.2  15     4.5  2488   25.3  15     3.9  2476   25.6  15     4.4  2317   26.1  14      
 11   4.0  2527   27.0  15     4.6  2535   26.7  15     4.5  2550   25.5  15     4.1  2565   26.0  15     4.1  2380   26.6  14      
 12   4.1  2513   27.1  15     4.6  2505   27.2  15     4.2  2490   25.9  15     4.3  2490   26.5  15     4.7  2324   27.3  14      
 13   4.1  2535   27.6  15     4.4  2535   27.6  15     4.3  2540   26.8  15     4.0  2565   26.8  15     4.3  2380   27.3  14      
 14   4.3  2520   28.0  15     4.2  2520   27.8  15     4.3  2520   27.3  15     4.1  2520   27.3  15     4.3  2352   28.1  14      
 15   4.2  2520   28.3  15     4.4  2520   28.2  15     4.5  2520   27.4  15     4.0  2520   27.5  15     4.1  2352   28.1  14      
 16   4.4  2394   28.6  14     4.4  2520   28.4  15     4.0  2520   27.0  15     4.1  2505   28.1  15     4.4  2352   28.4  14      
 17   4.4  2310   29.1  14     4.5  2520   28.8  15     4.4  2520   27.8  15     4.2  2535   28.2  15     4.5  2352   29.0  14      
 18   4.3  2394   29.4  14     4.5  2505   29.2  15     4.2  2338   28.7  14     4.4  2490   28.9  15     4.4  2338   29.3  14      
 19   4.3  2310   29.8  14     4.3  2535   29.4  15     4.1  2366   29.0  14     3.9  2544   28.9  15     4.1  2366   29.4  14      
 20   4.2  2338   30.1  14     4.1  2505   29.3  15     4.1  2338   29.1  14     3.8  2520   28.8  15     4.3  2348   30.2  14      
 21   4.1  2352   30.3  14     4.2  2520   29.6  15     4.2  2352   29.7  14     3.9  2505   29.3  15     4.2  2342   30.4  14      
 22   4.0  3360   30.0  14     4.3  2520   29.5  15     4.1  2352   29.5  14     4.1  2520   29.6  15     3.9  2352   30.0  14      
 23   4.1  1358   30.8  14     4.3  2535   29.0  15     4.2  2366   29.8  14     3.7  2520   29.0  15     3.9  2363   29.9  14      
 24   4.1  2362   30.6  14     4.3  2535   29.6  15     4.2  2366   29.8  14     3.7  2550   29.0  15     4.0  2380   29.7  14      
 25   3.9  2338   30.4  14     4.3  2505   29.6  15     4.2  2338   29.8  14     4.0  2505   29.2  15     3.8  2338   29.2  14      
 26   4.1  2352   30.9  14     4.4  2511   30.0  15     4.2  2338   29.7  14     4.0  2505   29.5  15     4.3  2336   29.5  14      
 27   4.0  2394   30.8  14     4.1  2550   29.8  15     4.1  2352   30.0  14     4.0  2483   29.6  15     4.0  2352   29.6  14      
 28   4.3  2352   31.0  14     4.2  2535   29.9  15     4.0  2352   29.9  14     3.9  2520   29.7  15     3.9  2366   28.8  14      
 29   4.2  2366   31.2  14     4.2  2535   30.2  15     4.1  2366   29.9  14     4.0  2535   29.8  15     4.1  2358   29.0  14      
 30   4.5  2296   31.8  14     4.4  2460   30.6  15     4.3  2366   29.8  14     4.2  2535   30.2  15     4.2  2366   29.3  14      
 31   4.4  2352   32.3  14     4.4  2520   31.0  15     4.3  2145   30.3  13     4.2  2520   30.0  15     4.2  2310   29.4  14      
 32   4.5  2352   32.6  14     4.3  2520   31.0  15     4.3  2184   30.6  13     4.1  2535   29.9  15     4.2  2366   29.5  14      
 33   4.3  2352   32.4  14     4.3  2520   30.9  15     4.3  2184   30.3  13     4.2  2505   29.8  15     4.3  2352   29.7  14      
 34   4.3  2352   32.3  14     4.3  2520   30.6  15     4.5  2184   30.5  13     4.1  2535   29.9  15     4.6  2352   30.3  14      
 35   4.6  2366   32.2  14     4.5  2535   30.7  15     4.2  2197   30.2  13     4.5  2535   29.7  15     4.3  2380   30.1  14      
 36   4.4  2338   32.4  14     4.4  2505   30.9  15     4.2  2171   30.1  13     4.2  2490   29.9  15     4.3  2324   30.1  14      
 37   4.2  2366   31.6  14     4.4  2531   30.6  15     4.3  2197   30.1  13     4.2  2535   29.7  15     4.0  2366   29.7  14      
 38   4.3  2352   31.9  14     4.4  2520   30.9  15     4.4  2171   30.1  13     4.1  2505   29.3  15     4.3  2326   29.9  14      
 39   4.1  2366   31.9  14     4.2  2535   30.4  15     4.4  2197   29.6  13     3.9  2535   29.4  15     4.4  2366   30.1  14      
 40   4.2  2338   31.3  14     4.3  2508   30.3  15     4.3  2165   29.7  13     4.5  2479   29.8  15     4.3  2327   30.1  14      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           24.7                     24.5                     23.8                     23.8                     24.3          
14 TO 52          30.8                     29.9                     29.5                     29.3                     29.5          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                                   
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                   
==============================                                                                                                      
        50000   PPM                                                                                                                 
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B               20.2  15                                                                                                          
  1               20.2  15                                                                                                          
  2   3.9  2505   21.4  15                                                                                                          
  3   3.7  2520   21.6  15                                                                                                          
  4   3.8  2520   22.5  15                                                                                                          
  5   4.0  2520   23.0  15                                                                                                          
  6   4.0  2520   23.3  15                                                                                                          
  7   4.0  2535   24.1  15                                                                                                          
  8   4.1  2505   24.5  15                                                                                                          
  9   3.8  2505   24.8  15                                                                                                          
 10   4.0  2460   25.5  15                                                                                                          
 11   4.0  2402   25.8  14                                                                                                          
 12   4.5  2145   26.5  13                                                                                                          
 13   4.1  2559   27.0  14                                                                                                          
 14   4.1  2352   27.5  14                                                                                                          
 15   3.9  2338   27.5  14                                                                                                          
 16   4.2  2352   27.8  14                                                                                                          
 17   4.1  2366   28.1  14                                                                                                          
 18   4.3  2324   28.7  14                                                                                                          
 19   4.1  2380   29.2  14                                                                                                          
 20   3.9  2352   29.5  14                                                                                                          
 21   3.8  2338   29.5  14                                                                                                          
 22   3.8  2352   29.0  14                                                                                                          
 23   3.8  2352   29.1  14                                                                                                          
 24   3.8  2380   29.1  14                                                                                                          
 25   3.7  2338   29.1  14                                                                                                          
 26   4.0  2352   29.3  14                                                                                                          
 27   3.9  2310   29.4  14                                                                                                          
 28   3.9  2352   29.7  14                                                                                                          
 29   3.9  2366   29.7  14                                                                                                          
 30   4.1  2380   29.7  14                                                                                                          
 31   4.2  2338   30.2  14                                                                                                          
 32   4.0  2366   30.3  14                                                                                                          
 33   4.1  2352   30.5  14                                                                                                          
 34   4.0  2366   30.2  14                                                                                                          
 35   4.2  2374   30.2  14                                                                                                          
 36   4.1  2330   30.1  14                                                                                                          
 37   4.0  2366   30.1  14                                                                                                          
 38   4.2  2338   30.0  14                                                                                                          
 39   4.1  2357   29.9  14                                                                                                          
 40   4.1  2306   29.9  14                                                                                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           23.9                                                                                                              
14 TO 52          29.4                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                               
                                  26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                 
==================================================================================================================================  
      VEHICLE CONTROL              3125 PPM                 6250 PPM               12500   PPM              25000   PPM             
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               16.9  15                 16.4  15                 16.8  15                 16.3  15                 16.4  15      
  1               16.9  15                 16.4  15                 16.8  15                 16.3  15                 16.4  15      
  2   3.9  2520   18.5  15     4.1  2490   18.1  15     4.0  2502   18.2  15     4.2  2505   18.1  15     4.1  2505   18.2  15      
  3   4.4  2520   19.6  15     4.3  2520   19.2  15     4.0  2520   18.9  15     4.1  2535   18.7  15     4.2  2520   19.0  15      
  4   4.7  2535   20.0  15     4.8  2535   20.2  15     4.5  2535   19.9  15     4.7  2520   19.9  15     4.4  2520   20.1  15      
  5   4.9  2520   20.8  15     4.7  2520   20.5  15     4.7  2520   20.5  15     4.8  2535   20.3  15     4.5  2505   20.1  15      
  6   4.8  2505   21.0  15     4.7  2535   20.5  15     4.8  2535   21.2  15     4.6  2520   20.6  15     4.4  2520   20.6  15      
  7   5.2  2378   20.7  14     4.7  2520   20.7  15     4.8  2520   20.5  15     4.9  2535   20.6  15     4.7  2534   20.8  15      
  8   5.0  2352   21.5  14     4.5  2520   20.9  15     5.0  2520   21.4  15     4.8  2505   21.3  15     4.5  2492   21.0  15      
  9   4.8  2352   21.7  14     4.7  2505   21.5  15     5.0  2505   22.0  15     5.0  2505   21.4  15     4.9  2505   21.7  15      
 10   5.3  2338   22.1  13     5.0  2490   21.8  15     4.9  2490   22.0  15     4.8  2471   22.2  15     4.9  2475   21.7  15      
 11   5.6  2366   22.1  14     4.8  2550   22.0  15     5.3  2550   22.4  15     5.1  2565   22.3  15     5.1  2565   22.2  15      
 12   5.1  2338   22.0  14     4.8  2499   22.0  15     4.4  2490   22.6  15     5.1  2475   22.5  15     4.6  2490   22.3  15      
 13   5.1  2366   22.2  14     4.9  2536   22.6  15     4.7  2550   23.4  15     4.7  2565   22.5  15     4.8  2550   22.5  15      
 14   4.5  2352   22.6  14     4.4  2520   23.0  15     4.2  2520   23.5  15     4.5  2520   22.9  15     4.6  2520   22.9  15      
 15   4.3  2352   22.9  14     4.6  2352   23.2  14     4.3  2520   23.9  15     4.2  2520   22.9  15     5.1  2520   23.6  15      
 16   4.7  2394   22.7  14     5.0  2352   23.3  14     4.4  2520   24.0  15     5.1  2505   23.3  15     4.7  2520   23.4  15      
 17   4.9  2310   23.1  14     4.8  2352   23.4  14     4.9  2520   24.0  15     4.7  2535   23.6  15     4.7  2520   22.9  15      
 18   4.9  2394   23.3  14     4.8  2338   23.4  14     4.5  2505   24.4  15     5.6  2490   24.4  15     4.8  2505   23.3  15      
 19   4.6  2310   23.6  14     4.5  2366   23.5  14     4.3  2535   24.8  15     4.8  2550   24.6  15     4.6  2535   23.6  15      
 20   4.6  2338   23.7  14     4.3  2338   23.8  14     4.2  2505   24.8  15     4.5  2520   25.1  15     4.4  2520   23.8  15      
 21   4.0  2352   23.7  14     4.2  2352   23.5  14     4.3  2520   25.1  15     4.4  2505   25.1  15     4.3  2505   24.0  15      
 22   4.9  2352   24.1  14     4.4  2352   23.7  14     4.6  2520   25.0  15     4.9  2520   25.1  15     4.5  2520   23.7  15      
 23   4.8  2366   24.0  14     4.7  2366   23.4  14     4.7  2535   25.3  15     4.3  2520   24.9  15     4.7  2526   23.7  15      
 24   4.8  2366   24.2  14     4.7  2366   23.8  14     4.5  2536   25.5  15     4.5  2550   24.7  15     4.5  2551   23.8  15      
 25   4.8  2338   24.2  14     4.7  2338   23.6  14     4.6  2338   25.4  14     4.7  2505   24.7  15     4.6  2504   23.5  15      
 26   4.5  2352   24.3  14     4.6  2338   23.7  14     4.8  2338   25.7  14     4.8  2518   25.1  15     4.8  2496   24.3  15      
 27   4.7  2394   23.9  14     4.3  2380   23.4  14     4.5  2352   25.7  14     4.4  2475   25.1  15     4.4  2520   24.0  15      
 28   4.9  2352   24.5  14     4.4  2366   23.4  14     4.6  2352   25.8  14     4.8  2520   25.1  15     4.6  2535   23.9  15      
 29   4.6  2365   24.2  14     4.6  2365   23.4  14     4.7  2366   25.8  14     4.7  2535   25.1  15     4.5  2526   24.0  15      
 30   4.7  2296   25.0  14     4.5  2302   24.1  14     4.5  2366   25.5  14     4.6  2535   25.8  15     4.7  2535   24.2  15      
 31   4.4  2352   25.2  14     4.3  2345   24.1  14     4.4  2310   25.7  14     4.4  2520   26.0  15     4.6  2475   24.5  15      
 32   4.4  2352   25.3  14     4.4  2352   24.4  14     4.3  2352   25.8  14     4.4  2535   25.8  15     4.2  2535   24.3  15      
 33   4.7  2352   24.9  14     4.4  2352   24.0  14     4.5  2352   25.8  14     4.7  2505   25.9  15     4.7  2507   24.5  15      
 34   4.6  2352   25.2  14     4.6  2352   24.5  14     4.3  2352   25.9  14     4.4  2535   25.9  15     4.5  2520   24.9  15      
 35   4.8  2366   25.2  14     4.5  2366   24.7  14     6.8  2371   25.8  14     5.3  2535   25.8  15     5.1  2380   24.9  15      
 36   4.6  2338   25.4  14     4.5  2338   24.7  14     4.7  2167   26.4  14     4.4  2490   26.0  15     4.5  2490   25.1  15      
 37   4.7  2366   25.3  14     4.5  2352   24.6  14     4.5  2366   26.3  14     4.8  2535   26.0  15     4.6  2535   25.0  15      
 38   4.9  2352   25.7  14     4.5  2352   24.4  14     4.8  2338   26.6  14     4.9  2505   26.0  15     4.8  2490   25.4  15      
 39   4.4  2366   25.7  14     4.6  2366   24.4  14     4.5  2366   26.5  14     4.4  2535   25.8  15     4.9  2535   25.4  15      
 40   4.7  2352   26.1  14     4.5  2352   24.3  14     4.6  2352   26.2  14     4.6  2520   25.4  15     4.7  2520   25.3  15      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           20.7                     20.5                     20.8                     20.5                     20.5          
14 TO 52          24.4                     23.8                     25.4                     25.0                     24.2          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                                 
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                   
==============================                                                                                                      
        50000   PPM                                                                                                                 
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B               16.1  15                                                                                                          
  1               16.1  15                                                                                                          
  2   3.8  2505   17.7  15                                                                                                          
  3   4.0  2520   18.6  15                                                                                                          
  4   4.0  2520   19.3  15                                                                                                          
  5   4.2  2520   19.9  15                                                                                                          
  6   4.3  2520   20.3  15                                                                                                          
  7   4.6  2535   19.9  15                                                                                                          
  8   4.5  2505   21.3  15                                                                                                          
  9   4.3  2505   21.3  15                                                                                                          
 10   3.9  2460   21.9  15                                                                                                          
 11   4.6  2580   21.8  15                                                                                                          
 12   4.8  2460   21.9  15                                                                                                          
 13   4.6  2580   22.3  15                                                                                                          
 14   4.3  2520   22.6  15                                                                                                          
 15   4.6  2505   22.9  15                                                                                                          
 16   5.0  2520   23.1  15                                                                                                          
 17   4.0  2535   23.0  15                                                                                                          
 18   4.8  2490   23.5  15                                                                                                          
 19   4.6  2550   23.6  15                                                                                                          
 20   4.5  2520   24.1  15                                                                                                          
 21   4.3  2505   24.3  15                                                                                                          
 22   4.3  2520   24.0  15                                                                                                          
 23   4.1  2520   23.6  15                                                                                                          
 24   4.6  2550   24.2  15                                                                                                          
 25   4.4  2505   24.1  15                                                                                                          
 26   4.5  2520   24.4  15                                                                                                          
 27   4.5  2475   24.2  15                                                                                                          
 28   4.5  2520   24.3  15                                                                                                          
 29   4.3  2535   24.4  15                                                                                                          
 30   4.2  2550   24.3  15                                                                                                          
 31   4.3  2505   24.7  15                                                                                                          
 32   4.5  2535   24.6  15                                                                                                          
 33   4.6  2520   25.0  15                                                                                                          
 34   4.5  2535   24.6  15                                                                                                          
 35   4.6  2550   24.5  15                                                                                                          
 36   4.3  2490   24.9  15                                                                                                          
 37   4.3  2535   24.8  15                                                                                                          
 38   4.5  2505   25.1  15                                                                                                          
 39   4.5  2521   25.0  15                                                                                                          
 40   4.7  2520   25.1  15                                                                                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           20.2                                                                                                              
14 TO 52          24.2                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.