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TDMS Study 99033-03 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BIORELIANCE                           TRANSGENIC MODEL EVALUATION II (ASPARTAME)                               DATE: 03/05/03  
EXPERIMENT: 99033 TEST: 03                                                                                        TIME: 11:17:56    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED FEED                                             NTP:  C99033B     
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        FINAL #3 TG:P16 MICE                                                        
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BIORELIANCE                                      TRANSGENIC MODEL EVALUATION II (ASPARTAME)                  DATE: 03/05/03    
EXPERIMENT: 99033 TEST: 03                                                                                        TIME: 11:25:53    
SPECIES: MICE, TG:P16-INK4A                                                                                                         
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED FEED                                             NTP:  99033B      
CONT: N01-ES-65406                                                                                                CAS: 22839-47-0   
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                               
                  SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                               
==========================================================================================================================          
WEEK     VEHICLE CONTROL        3125 PPM                 6250 PPM                 12500   PPM              25000   PPM              
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        22.2       15        22.1     99.5    15      22.2    100.0    15      22.0     99.1    15      21.8     98.2    15      
  1        22.2       15        22.1     99.5    15      22.2    100.0    15      22.0     99.1    15      21.8     98.2    15      
  2        22.4       15        22.2     99.1    15      22.4    100.0    15      22.1     98.7    15      22.0     98.2    15      
  3        23.1       15        23.2    100.4    15      23.0     99.6    15      22.9     99.1    15      22.7     98.3    15      
  4        23.6       15        23.8    100.8    15      23.4     99.2    15      23.8    100.8    15      23.0     97.5    14      
  5        25.0       15        24.9     99.6    15      24.6     98.4    15      24.8     99.2    15      24.7     98.8    14      
  6        25.6       15        25.5     99.6    15      25.1     98.0    15      25.2     98.4    15      25.0     97.7    14      
  7        26.1       15        26.5    101.5    15      26.2    100.4    15      25.6     98.1    15      26.1    100.0    14      
  8        26.7       15        26.7    100.0    15      26.3     98.5    15      26.7    100.0    14      26.6     99.6    14      
  9        27.4       15        27.7    101.1    15      26.5     96.7    15      27.2     99.3    14      27.1     98.9    14      
 10        28.6       14        27.9     97.6    15      27.1     94.8    15      27.6     96.5    14      27.7     96.9    14      
 11        28.9       14        27.9     96.5    15      27.9     96.5    15      28.2     97.6    14      28.0     96.9    14      
 12        29.4       14        28.4     96.6    15      28.2     95.9    15      28.3     96.3    14      28.2     95.9    14      
 13        30.0       14        28.8     96.0    15      28.3     94.3    15      29.0     96.7    14      29.1     97.0    14      
 14        30.1       14        29.1     96.7    15      28.7     95.3    15      29.6     98.3    14      29.1     96.7    14      
 15        30.8       14        29.4     95.5    15      29.8     96.8    15      29.9     97.1    14      29.5     95.8    14      
 16        30.6       14        29.8     97.4    15      29.8     97.4    15      30.7    100.3    14      29.8     97.4    14      
 17        31.6       14        30.7     97.2    15      30.8     97.5    15      31.7    100.3    14      30.5     96.5    14      
 18        32.4       14        31.1     96.0    15      30.5     94.1    15      32.1     99.1    14      31.6     97.5    14      
 19        32.8       14        31.5     96.0    15      30.1     91.8    15      32.4     98.8    14      32.0     97.6    14      
 20        33.3       14        32.1     96.4    15      30.9     92.8    15      32.8     98.5    14      32.2     96.7    14      
 21        34.0       14        32.6     95.9    15      31.9     93.8    15      33.1     97.4    14      33.0     97.1    14      
 22        34.2       14        32.7     95.6    15      32.2     94.2    15      32.7     95.6    14      33.1     96.8    14      
 23        34.4       14        32.7     95.1    15      32.2     93.6    15      33.0     95.9    14      33.0     95.9    14      
 24        34.5       14        32.7     94.8    15      32.2     93.3    15      33.3     96.5    14      33.0     95.7    14      
 25        34.6       14        32.8     94.8    15      32.2     93.1    15      33.2     96.0    14      32.9     95.1    14      
 26        34.6       14        32.7     94.5    15      32.2     93.1    15      33.6     97.1    14      33.1     95.7    14      
 27        34.6       14        32.7     94.5    15      32.6     94.2    15      33.8     97.7    14      33.3     96.2    14      
 28        35.1       14        33.4     95.2    15      32.9     93.7    15      34.3     97.7    14      33.9     96.6    14      
 29        35.6       14        33.9     95.2    15      33.3     93.5    15      34.6     97.2    14      34.3     96.3    14      
 30        35.9       14        33.8     94.2    15      33.8     94.2    15      35.0     97.5    14      34.6     96.4    14      
 31        35.8       14        33.4     93.3    15      33.9     94.7    15      34.8     97.2    14      34.5     96.4    14      
 32        36.1       14        33.5     92.8    15      33.7     93.4    15      34.8     96.4    14      34.6     95.8    14      
 33        35.6       14        33.5     94.1    15      34.0     95.5    15      34.3     96.3    14      34.6     97.2    14      
 34        36.1       14        33.1     91.7    15      34.2     94.7    15      34.9     96.7    14      35.1     97.2    14      
 35        35.4       14        33.0     93.2    14      33.9     95.8    15      35.3     99.7    14      34.8     98.3    14      
 36        35.6       14        33.6     94.4    14      34.3     96.3    15      35.5     99.7    14      35.3     99.2    14      
 37        35.6       14        33.1     93.0    14      34.1     95.8    15      35.1     98.6    14      34.9     98.0    14      
 38        35.9       14        32.6     90.8    14      34.0     94.7    15      35.2     98.1    14      35.0     97.5    14      
 39        35.6       14        32.4     91.0    14      33.9     95.2    15      34.9     98.0    14      35.4     99.4    14      
 40        35.7       14        33.1     92.7    14      33.7     94.4    15      35.0     98.0    14      35.6     99.7    14      
TERM. SAC.            14                         14                       15                       14                       14      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                                                                  
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                 
===============================                                                                                                     
     50000   PPM                                                                                                                    
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    21.9     98.6    15                                                                                                          
  1    21.9     98.6    15                                                                                                          
  2    22.3     99.6    15                                                                                                          
  3    23.0     99.6    15                                                                                                          
  4    23.6    100.0    15                                                                                                          
  5    24.9     99.6    15                                                                                                          
  6    25.1     98.0    15                                                                                                          
  7    26.4    101.1    15                                                                                                          
  8    26.5     99.3    15                                                                                                          
  9    26.9     98.2    15                                                                                                          
 10    27.3     95.5    15                                                                                                          
 11    28.1     97.2    15                                                                                                          
 12    28.9     98.3    15                                                                                                          
 13    29.2     97.3    15                                                                                                          
 14    29.4     97.7    15                                                                                                          
 15    29.9     97.1    15                                                                                                          
 16    30.4     99.3    15                                                                                                          
 17    31.4     99.4    15                                                                                                          
 18    31.6     97.5    15                                                                                                          
 19    32.1     97.9    15                                                                                                          
 20    32.7     98.2    15                                                                                                          
 21    32.8     96.5    15                                                                                                          
 22    33.1     96.8    15                                                                                                          
 23    33.0     95.9    15                                                                                                          
 24    33.4     96.8    15                                                                                                          
 25    33.3     96.2    15                                                                                                          
 26    33.5     96.8    15                                                                                                          
 27    33.7     97.4    15                                                                                                          
 28    33.8     96.3    15                                                                                                          
 29    33.9     95.2    15                                                                                                          
 30    34.3     95.5    15                                                                                                          
 31    34.4     96.1    15                                                                                                          
 32    34.0     94.2    15                                                                                                          
 33    33.9     95.2    15                                                                                                          
 34    34.4     95.3    15                                                                                                          
 35    34.3     96.9    15                                                                                                          
 36    34.3     96.3    15                                                                                                          
 37    33.9     95.2    15                                                                                                          
 38    34.1     95.0    15                                                                                                          
 39    34.4     96.6    15                                                                                                          
 40    34.2     95.8    15                                                                                                          
TERM. SAC.              15                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                             
                  SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                               
==========================================================================================================================          
WEEK     VEHICLE CONTROL        3125 PPM                 6250 PPM                 12500   PPM              25000   PPM              
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        17.9       15        18.4    102.8    15      18.3    102.2    15      18.2    101.7    15      17.9    100.0    15      
  1        17.9       15        18.4    102.8    15      18.3    102.2    15      18.2    101.7    15      17.9    100.0    15      
  2        18.7       15        19.0    101.6    15      18.4     98.4    15      18.6     99.5    15      18.6     99.5    15      
  3        19.8       14        20.3    102.5    15      19.8    100.0    15      20.0    101.0    15      19.6     99.0    15      
  4        20.7       14        21.0    101.4    15      20.6     99.5    15      20.8    100.5    15      20.3     98.1    15      
  5        21.2       14        21.6    101.9    15      21.9    103.3    15      21.4    100.9    15      20.9     98.6    15      
  6        22.1       14        22.3    100.9    15      22.4    101.4    15      22.3    100.9    15      21.8     98.6    15      
  7        22.5       14        23.0    102.2    15      22.6    100.4    15      22.8    101.3    15      22.3     99.1    15      
  8        21.8       14        22.3    102.3    15      22.6    103.7    15      22.9    105.0    15      22.0    100.9    15      
  9        22.7       14        23.1    101.8    15      23.0    101.3    15      23.0    101.3    15      22.1     97.4    15      
 10        23.1       14        23.4    101.3    15      22.8     98.7    15      23.7    102.6    15      22.8     98.7    15      
 11        23.0       14        23.6    102.6    15      23.7    103.0    15      23.9    103.9    15      22.9     99.6    15      
 12        23.3       14        24.1    103.4    15      24.0    103.0    15      24.7    106.0    15      23.1     99.1    15      
 13        23.5       14        24.5    104.3    15      23.8    101.3    15      25.0    106.4    15      23.8    101.3    15      
 14        23.3       14        24.2    103.9    15      24.0    103.0    15      24.6    105.6    15      23.3    100.0    15      
 15        24.3       14        25.0    102.9    15      25.1    103.3    15      25.1    103.3    15      23.8     97.9    15      
 16        24.3       14        24.9    102.5    15      25.1    103.3    15      25.3    104.1    15      23.7     97.5    15      
 17        24.4       14        25.7    105.3    15      26.1    107.0    14      25.8    105.7    15      24.2     99.2    15      
 18        24.8       14        25.8    104.0    15      26.1    105.2    14      25.8    104.0    15      24.9    100.4    15      
 19        25.1       14        26.3    104.8    15      26.1    104.0    14      26.2    104.4    15      25.1    100.0    15      
 20        25.3       14        26.7    105.5    15      25.5    100.8    14      26.3    104.0    15      25.1     99.2    15      
 21        25.7       14        27.2    105.8    15      26.1    101.6    14      26.9    104.7    15      25.6     99.6    15      
 22        25.4       14        27.0    106.3    15      26.7    105.1    14      26.8    105.5    15      25.4    100.0    15      
 23        25.3       14        26.8    105.9    15      26.7    105.5    14      26.6    105.1    15      25.7    101.6    15      
 24        25.7       14        27.2    105.8    15      26.9    104.7    14      26.5    103.1    15      25.4     98.8    15      
 25        25.9       14        27.4    105.8    15      26.4    101.9    14      26.7    103.1    15      25.3     97.7    15      
 26        26.2       14        27.3    104.2    15      26.7    101.9    14      26.8    102.3    15      25.4     96.9    15      
 27        25.6       14        26.9    105.1    15      26.5    103.5    14      27.0    105.5    15      25.6    100.0    15      
 28        26.2       14        27.9    106.5    15      27.4    104.6    14      27.4    104.6    15      25.9     98.9    15      
 29        26.8       14        28.1    104.9    15      27.0    100.7    14      27.6    103.0    15      26.1     97.4    15      
 30        26.4       14        28.5    108.0    15      27.2    103.0    14      27.8    105.3    15      26.4    100.0    15      
 31        25.6       14        28.2    110.2    15      28.3    110.5    14      27.7    108.2    15      26.3    102.7    15      
 32        26.2       14        28.1    107.3    15      27.8    106.1    13      27.7    105.7    15      26.7    101.9    15      
 33        26.8       13        28.0    104.5    15      28.1    104.9    13      27.5    102.6    15      26.5     98.9    15      
 34        27.1       13        28.4    104.8    15      28.3    104.4    13      27.7    102.2    15      26.9     99.3    15      
 35        27.0       13        28.0    103.7    15      27.9    103.3    13      28.0    103.7    15      26.9     99.6    15      
 36        27.0       13        28.1    104.1    15      28.1    104.1    13      28.0    103.7    15      26.4     97.8    15      
 37        26.8       13        27.6    103.0    15      27.7    103.4    13      27.8    103.7    15      26.8    100.0    15      
 38        26.9       13        27.7    103.0    15      28.0    104.1    13      27.8    103.3    15      26.6     98.9    15      
 39        26.7       13        27.6    103.4    15      28.3    106.0    13      28.2    105.6    15      27.1    101.5    15      
 40        27.4       13        27.9    101.8    15      28.8    105.1    13      28.6    104.4    15      26.9     98.2    15      
TERM. SAC.            13                         15                       13                       15                       15      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                                                
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                 
===============================                                                                                                     
     50000   PPM                                                                                                                    
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    18.2    101.7    15                                                                                                          
  1    18.2    101.7    15                                                                                                          
  2    18.8    100.5    15                                                                                                          
  3    20.0    101.0    15                                                                                                          
  4    20.7    100.0    15                                                                                                          
  5    21.9    103.3    15                                                                                                          
  6    22.5    101.8    15                                                                                                          
  7    22.6    100.4    15                                                                                                          
  8    22.5    103.2    15                                                                                                          
  9    22.8    100.4    15                                                                                                          
 10    23.1    100.0    15                                                                                                          
 11    23.6    102.6    15                                                                                                          
 12    23.9    102.6    15                                                                                                          
 13    23.9    101.7    15                                                                                                          
 14    24.2    103.9    15                                                                                                          
 15    24.8    102.1    15                                                                                                          
 16    24.5    100.8    15                                                                                                          
 17    25.6    104.9    15                                                                                                          
 18    25.7    103.6    15                                                                                                          
 19    25.8    102.8    15                                                                                                          
 20    26.0    102.8    15                                                                                                          
 21    26.5    103.1    15                                                                                                          
 22    26.5    104.3    15                                                                                                          
 23    26.7    105.5    15                                                                                                          
 24    26.6    103.5    15                                                                                                          
 25    26.2    101.2    15                                                                                                          
 26    26.2    100.0    15                                                                                                          
 27    26.7    104.3    15                                                                                                          
 28    26.9    102.7    15                                                                                                          
 29    26.7     99.6    15                                                                                                          
 30    27.1    102.7    15                                                                                                          
 31    27.5    107.4    15                                                                                                          
 32    27.4    104.6    15                                                                                                          
 33    27.6    103.0    15                                                                                                          
 34    28.1    103.7    15                                                                                                          
 35    27.8    103.0    15                                                                                                          
 36    28.0    103.7    15                                                                                                          
 37    27.7    103.4    15                                                                                                          
 38    27.7    103.0    15                                                                                                          
 39    27.8    104.1    15                                                                                                          
 40    28.3    103.3    14                                                                                                          
TERM. SAC.              14                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.