National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14529

TDMS Study 99039-02 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BIORELIANCE                                 TRANSGENIC MODEL EVALUATION II                                     DATE: 02/21/03  
EXPERIMENT: 99039 TEST: 02                                                                                        TIME: 13:01:29    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: DOSED FEED                                             NTP:  C99039      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        FINAL#3/P53 +/- MICE                                                        
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BIORELIANCE                                      TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)      DATE: 02/21/03    
EXPERIMENT: 99039 TEST: 02                                                                                        TIME: 13:07:33    
SPECIES: MICE, P53+/-(C57BL/6)                                                                                                      
TEST TYPE: 26                                       ROUTE: DOSED FEED                                             NTP:  C99039      
CONT: NO1-ES-75408                                                                                                CAS: 55589-62-3   
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                                     
               26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                                        
==========================================================================================================                          
WEEK     VEHICLE CONTROL        0.3 %                    1.0 %                    3.0 %                                             
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        20.9       15        20.5     98.1    15      20.5     98.1    15      21.1    101.0    15                               
  1        20.9       15        20.5     98.1    15      20.5     98.1    15      21.1    101.0    15                               
  2        21.9       15        21.7     99.1    15      22.0    100.5    15      22.0    100.5    15                               
  3        22.1       15        21.9     99.1    15      22.3    100.9    15      22.1    100.0    15                               
  4        22.9       15        22.5     98.3    15      22.8     99.6    15      22.7     99.1    15                               
  5        23.6       15        23.6    100.0    15      23.9    101.3    15      24.1    102.1    15                               
  6        24.1       15        23.9     99.2    15      24.4    101.2    15      24.4    101.2    15                               
  7        24.5       15        24.2     98.8    15      25.0    102.0    15      24.7    100.8    15                               
  8        25.3       15        24.8     98.0    15      25.5    100.8    15      25.2     99.6    15                               
  9        25.4       15        24.9     98.0    15      25.6    100.8    15      25.4    100.0    15                               
 10        25.6       15        25.1     98.0    15      26.1    102.0    15      25.6    100.0    15                               
 11        25.9       15        25.4     98.1    15      26.8    103.5    15      25.7     99.2    15                               
 12        26.5       15        25.6     96.6    15      27.1    102.3    15      26.3     99.2    15                               
 13        26.6       15        25.9     97.4    15      26.9    101.1    15      26.5     99.6    15                               
 14        27.0       15        26.7     98.9    15      27.2    100.7    15      27.0    100.0    15                               
 15        27.5       15        27.2     98.9    15      28.3    102.9    15      27.9    101.5    15                               
 16        28.0       15        27.9     99.6    15      28.4    101.4    15      28.1    100.4    15                               
 17        28.5       15        27.7     97.2    15      28.9    101.4    15      28.2     98.9    15                               
 18        29.4       15        28.8     98.0    15      30.1    102.4    15      29.1     99.0    15                               
 19        29.2       15        28.3     96.9    15      29.8    102.1    15      28.9     99.0    15                               
 20        29.4       15        28.6     97.3    15      29.2     99.3    15      29.1     99.0    15                               
 21        29.7       15        28.8     97.0    15      30.0    101.0    15      29.4     99.0    15                               
 22        29.5       15        29.0     98.3    15      29.9    101.4    15      29.5    100.0    15                               
 23        29.2       15        28.5     97.6    15      29.6    101.4    15      29.5    101.0    15                               
 24        29.6       15        29.2     98.6    15      30.3    102.4    15      30.3    102.4    15                               
 25        29.6       15        28.9     97.6    15      30.5    103.0    15      29.9    101.0    15                               
 26        29.6       15        29.4     99.3    15      30.5    103.0    15      30.3    102.4    15                               
 27        29.0       15        29.0    100.0    15      30.9    106.6    15      30.4    104.8    15                               
 28        29.3       15        29.8    101.7    15      31.9    108.9    15      31.0    105.8    15                               
 29        30.3       14        30.2     99.7    15      32.1    105.9    15      30.5    100.7    15                               
 30        30.4       14        30.5    100.3    15      32.4    106.6    15      31.1    102.3    15                               
 31        30.1       14        30.0     99.7    15      32.2    107.0    15      31.1    103.3    15                               
 32        29.9       14        29.3     98.0    15      32.0    107.0    15      30.9    103.3    15                               
 33        29.6       14        29.5     99.7    15      31.1    105.1    15      30.4    102.7    14                               
 34        29.2       14        29.2    100.0    15      31.3    107.2    15      30.2    103.4    14                               
 35        29.2       14        29.3    100.3    15      30.8    105.5    15      29.6    101.4    14                               
 36        29.1       14        29.3    100.7    15      31.0    106.5    15      29.4    101.0    14                               
 37        29.1       14        29.7    102.1    15      31.1    106.9    15      29.7    102.1    14                               
 38        29.1       14        29.5    101.4    15      31.3    107.6    15      29.9    102.7    14                               
 39        29.2       14        29.9    102.4    15      31.7    108.6    15      30.1    103.1    14                               
 40        29.5       14        30.1    102.0    15      31.6    107.1    15      29.9    101.4    14                               
TERM. SAC.            14                         15                       15                       14                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                   
               26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                                        
==========================================================================================================                          
WEEK     VEHICLE CONTROL        0.3 %                    1.0 %                    3.0 %                                             
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        16.4       15        17.0    103.7    15      17.0    103.7    15      16.4    100.0    15                               
  1        16.4       15        17.0    103.7    15      17.0    103.7    15      16.4    100.0    15                               
  2        18.5       15        17.9     96.8    15      18.4     99.5    15      17.8     96.2    15                               
  3        18.4       15        18.7    101.6    15      19.2    104.3    15      18.5    100.5    15                               
  4        19.6       15        19.5     99.5    15      19.9    101.5    15      19.1     97.4    15                               
  5        20.2       15        20.7    102.5    15      20.6    102.0    15      20.1     99.5    15                               
  6        20.9       15        21.1    101.0    15      21.2    101.4    15      21.0    100.5    15                               
  7        21.0       15        21.2    101.0    15      21.5    102.4    15      21.1    100.5    15                               
  8        21.4       15        21.5    100.5    15      21.5    100.5    15      20.8     97.2    15                               
  9        21.4       15        21.5    100.5    15      21.7    101.4    15      21.3     99.5    15                               
 10        21.8       15        21.6     99.1    15      21.9    100.5    15      21.6     99.1    15                               
 11        22.4       15        22.4    100.0    15      22.4    100.0    15      21.8     97.3    15                               
 12        22.6       15        22.3     98.7    15      22.6    100.0    15      22.3     98.7    15                               
 13        23.0       15        23.1    100.4    15      23.2    100.9    15      22.8     99.1    15                               
 14        23.2       15        23.6    101.7    15      23.5    101.3    15      22.9     98.7    15                               
 15        23.6       15        24.2    102.5    15      23.7    100.4    15      22.9     97.0    15                               
 16        24.1       15        25.2    104.6    15      24.2    100.4    15      23.6     97.9    15                               
 17        24.3       15        25.1    103.3    15      24.2     99.6    15      23.7     97.5    15                               
 18        24.7       15        25.6    103.6    15      25.0    101.2    15      24.1     97.6    15                               
 19        24.8       15        25.8    104.0    15      24.9    100.4    14      24.6     99.2    15                               
 20        25.1       15        26.1    104.0    15      25.5    101.6    14      24.9     99.2    15                               
 21        25.4       15        26.4    103.9    15      25.7    101.2    14      25.3     99.6    15                               
 22        25.6       15        26.8    104.7    15      26.1    102.0    14      25.5     99.6    15                               
 23        26.1       15        27.0    103.4    15      26.3    100.8    14      25.6     98.1    15                               
 24        26.1       15        26.9    103.1    15      26.6    101.9    14      26.0     99.6    15                               
 25        26.4       14        26.9    101.9    15      26.7    101.1    14      26.3     99.6    15                               
 26        26.5       14        27.1    102.3    14      26.5    100.0    14      26.3     99.2    15                               
 27        26.7       14        27.3    102.2    14      27.2    101.9    14      26.9    100.7    15                               
 28        26.9       14        27.8    103.3    14      27.4    101.9    14      27.4    101.9    15                               
 29        27.0       14        28.0    103.7    14      28.0    103.7    14      27.1    100.4    15                               
 30        28.2       14        28.6    101.4    14      28.5    101.1    14      28.0     99.3    15                               
 31        27.8       14        28.6    102.9    14      28.5    102.5    14      27.9    100.4    15                               
 32        28.1       14        27.9     99.3    14      28.5    101.4    14      27.5     97.9    15                               
 33        27.5       14        28.0    101.8    14      28.4    103.3    14      27.9    101.5    15                               
 34        27.7       14        27.8    100.4    14      28.3    102.2    14      27.5     99.3    15                               
 35        27.6       14        27.3     98.9    14      27.7    100.4    14      26.8     97.1    15                               
 36        27.3       14        28.1    102.9    14      28.2    103.3    14      27.1     99.3    14                               
 37        27.5       14        28.0    101.8    14      28.0    101.8    14      27.6    100.4    14                               
 38        27.7       14        28.1    101.4    14      27.9    100.7    14      27.6     99.6    14                               
 39        27.5       14        28.3    102.9    14      28.2    102.5    14      28.0    101.8    14                               
 40        28.3       14        28.8    101.8    14      28.8    101.8    14      28.3    100.0    14                               
TERM. SAC.            14                         14                       14                       14                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
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