TDMS Study 05099-98 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST DATE: 05/09/95
EXP: 05099 SALICYLAZOSULFAPYRIDINE TIME: 15:27:06
TEST: 98 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 61552B
CONT: N01-ES-85233 CAS: 599-79-1
PATHOLOGIST: DR J. HEATH
--------------------------------------------------------------------------------
05099/07 -VS- 05099/09 COMPARISON
REASONS FOR REMOVAL:
25004 Dead
25018 Dosing Accident
25014 Gavage Death
25005 Interval Sacrifice
25003 Moribund
25019 Moribund Sacrifice
25020 Natural Death
25017 Scheduled Sacrifice
25021 Terminal Sacrifice
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE 001 0 MG/KG AD LIB
INCLUDE 004 0 MG/KG RTD
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST DATE: 05/09/95
EXP: 05099 SALICYLAZOSULFAPYRIDINE TIME: 15:27:06
TEST: 98 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 61552B
CONT: N01-ES-85233 CAS: 599-79-1
PATHOLOGIST: DR J. HEATH
SALICYLAZOSULFAPYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG AD LIB |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 14 CENSORED DEATHS 21 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 473 477 500 523 551 605 632 653 676 684 |
| 708 717 717 726 |
| CENSORED DEATHS |
| 150 183 183 183 183 183 183 183 183 183 |
| 183 456 456 456 456 456 457 457 457 457 |
| 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0 MG/KG RTD |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 12 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 437 520 597 627 631 645 645 667 680 682 |
| 690 698 700 703 722 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 478 639 |
| |
==================================================================================
SALICYLAZOSULFAPYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 95.9 91.8 87.8 83.7 71.4 |
|MG/KG AD LI| |
| | |
|0 MG/KG RTD| 100.0 100.0 100.0 100.0 100.0 98.3 96.3 94.2 85.9 69.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 0 MG/KG RTD |
| MG/KG AD LIB |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 71.4% 69.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 617.3 642.9 |
|NATURAL DEATHS (C) | (25.4) (19.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 581.5 656.3 |
|(STANDARD ERROR) | (24.2) (14.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SALICYLAZOSULFAPYRIDINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG AD LIB = 1
0 MG/KG RTD = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 2
| 11
| 1 1 2 2
95 +
| 1 1 2 2
P | 22
E | 1 1
R 90 + 1 1 2 2
C |
E | 1 1
N | 1 21 2
T 85 +
| 1 212
S |
U | 11
R 80 + 12 1
V |
I | 22 11
V |
A 75 +
L | 22 11
|
| 2 1 1
70 +
| 2 2
|
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.