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TDMS Study 05121-99 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE


NTP Experiment-Test: 05121-99                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 03/15/95
Route: GAVAGE                                                                                                     Time: 17:21:13


                                                 05121/07 - 05121/08 COMPARISON


       Facility:  BATTELLE COLUMBUS LABORATORY

       Chemical CAS #:  6533-68-2

       Lock Date:  06/01/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25018 Dosing Accident
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/KG
                               Include 002    0 MG/KG
                               Include 003    RTD     0 MG/KG
                               Include 005    RTD     0 MG/KG


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           60                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      7            1                                                               
    Moribund Sacrifice                                 9            2                                                               
    Dosing Accident                                    2                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           47                                                               

  Animals Examined Microscopically                    51           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (51)         (50)                                                             
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (51)         (50)                                                             
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                         7 (14%)                                                                      
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                          10 (20%)      3 (6%)                                                          
      Hepatocellular Adenoma, Multiple                 5 (10%)                                                                      
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Bile Duct, Carcinoma                             1 (2%)                                                                       
   Mesentery                                          (7)          (2)                                                              
      Carcinoma, Metastatic, Liver                     1 (14%)                                                                      
      Histiocytic Sarcoma                                           1 (50%)                                                         
   Pancreas                                           (51)         (50)                                                             
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (51)         (50)                                                             
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (51)         (49)                                                             
   Adrenal Medulla                                    (51)         (49)                                                             
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (46)                                                             

                                                             Page   2                                                               
NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                           4 (8%)                                                                       
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (51)         (50)                                                             
      Follicular Cell, Adenoma                         3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (51)         (50)                                                             
      Cystadenoma                                      3 (6%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Uterus                                             (51)         (50)                                                             
      Adenoma                                          1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Ovary               1 (2%)                                                                       
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Polyp Stromal                                    1 (2%)                                                                       
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (51)         (50)                                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Lymph Node                                         (6)                                                                           
      Bronchial, Carcinoma, Metastatic, Liver          1 (17%)                                                                      
      Bronchial, Hepatocholangiocarcinoma,                                                                                          
          Metastatic, Liver                            1 (17%)                                                                      
      Mediastinal, Carcinoma, Metastatic, Liver        1 (17%)                                                                      
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                            1 (17%)                                                                      
      Mediastinal, Histiocytic Sarcoma                 1 (17%)                                                                      
   Lymph Node, Mandibular                             (50)         (50)                                                             
   Lymph Node, Mesenteric                             (50)         (44)                                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mediastinal                                         (2)                                                              
      Histiocytic Sarcoma                                           1 (50%)                                                         
   Spleen                                             (51)         (50)                                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (48)         (45)                                                             

                                                             Page   3                                                               
NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (50)                                                             
      Carcinoma                                                     1 (2%)                                                          
   Skin                                               (51)         (50)                                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (51)         (50)                                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (2)                                                              
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                     3 (6%)       3 (6%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                      2 (4%)                                                          
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Ovary               1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (17)         (24)                                                             
      Adenoma                                          1 (6%)       3 (13%)                                                         
      Carcinoma                                        2 (12%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (51)         (50)                                                             
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(51)        *(50)                                                             
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                                                          
      Lymphoma Malignant Lymphocytic                   2 (4%)                                                                       
      Lymphoma Malignant Mixed                         7 (14%)      2 (4%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          19                                                               
     Total Primary Neoplasms                           62          20                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 24          12                                                               
     Total Benign Neoplasms                            31          12                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26           8                                                               
     Total Malignant Neoplasms                         31           8                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           1                                                               
     Total Metastatic Neoplasm                         19           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           60                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      5            1                                                               
    Moribund Sacrifice                                 4                                                                            
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                40           49                                                               

  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (50)                                                             
      Adenoma                                          1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (49)                                                             
   Liver                                              (50)         (50)                                                             
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Hepatocellular Carcinoma                         6 (12%)      2 (4%)                                                          
      Hepatocellular Adenoma                          10 (20%)      3 (6%)                                                          
      Hepatocellular Adenoma, Multiple                16 (32%)                                                                      
      Histiocytic Sarcoma                              3 (6%)                                                                       
      Ito Cell Tumor NOS, Multiple                     1 (2%)                                                                       
   Mesentery                                          (4)          (1)                                                              
   Pancreas                                           (50)         (50)                                                             
   Tooth                                              (14)         (2)                                                              
      Odontoma                                         1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (49)         (50)                                                             
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)                                                             
      Adenoma                                          3 (6%)                                                                       
   Pituitary Gland                                    (48)         (48)                                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

                                                             Page   7                                                               
NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (50)         (50)                                                             
      Interstitial Cell, Adenoma                                    2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
   Lymph Node                                         (2)                                                                           
   Lymph Node, Mandibular                             (49)         (50)                                                             
   Lymph Node, Mesenteric                             (48)         (50)                                                             
      Histiocytic Sarcoma                              3 (6%)                                                                       
   Lymph Node, Mediastinal                                         (1)                                                              
   Spleen                                             (50)         (50)                                                             
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (4%)                                                                       
   Thymus                                             (42)         (45)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)                                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                    11 (22%)      8 (16%)                                                         
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (16)         (22)                                                             
      Adenoma                                          3 (19%)      2 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Renal Tubule, Carcinoma                          2 (4%)                                                                       
   Urinary Bladder                                    (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)                                                             
      Histiocytic Sarcoma                              3 (6%)                                                                       
      Leukemia Lymphocytic                             1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Mixed                         3 (6%)                                                                       
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   9                                                               
NTP Experiment-Test: 05121-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 03/15/95  
Route: GAVAGE                                                                                                     Time: 17:21:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      RTD                                                                 
                                                                0 MG/KG                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          19                                                               
     Total Primary Neoplasms                           69          23                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          14                                                               
     Total Benign Neoplasms                            48          16                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17           6                                                               
     Total Malignant Neoplasms                         20           7                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                                                                           
     Total Metastatic Neoplasm                          6                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  10                                                               
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