National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4045

TDMS Study 05121-99 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: BATTELLE COLUMBUS                                         DATE: 03/16/95   
EXP: 05121           SCOPOLAMINE HYDROBROMIDE TRIHYDRATE       TIME: 12:24:41   
TEST: 99              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 03098C   
CONT: N01-ES-85227                                             CAS: 6533-68-2   
PATHOLOGIST: A. SINGER                                                          
--------------------------------------------------------------------------------
                                                                                
                         05121/07 - 05121/08 COMPARISON                         
                                                                                

REASONS FOR REMOVAL:                                                            
                                                                                
25022 Accidently Killed                                                         
25018 Dosing Accident                                                           
25019 Moribund Sacrifice                                                        
25020 Natural Death                                                             
25021 Terminal Sacrifice                                                        
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             

ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE 001    0 MG/KG                                                          
INCLUDE 002    0 MG/KG                                                          
INCLUDE 003    RTD     0 MG/KG                                                  
INCLUDE 005    RTD     0 MG/KG                                                  
NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: BATTELLE COLUMBUS                                         DATE: 03/16/95  
EXP: 05121           SCOPOLAMINE HYDROBROMIDE TRIHYDRATE       TIME: 12:24:41  
TEST: 99              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 03098C  
CONT: N01-ES-85227                                             CAS: 6533-68-2  
PATHOLOGIST: A. SINGER                                                         
                        SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 722 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 0    TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      294   447   540   647   680   683   694   700   707                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = RTD     0 MG/KG                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 1      CENSORED DEATHS 0    TERMINAL 49        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      515                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                        SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 722 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   722 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0  98.0  98.0  96.0  94.0  94.0  92.0  82.0      |
 |           |                                                                    |
 |           |                                                                    |
 |RTD        |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0  98.0  98.0      |
 |0 MG/KG    |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                0 MG/KG                   RTD                   |
 |                                                          0 MG/KG               |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       82.0%                     98.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----                     -----                |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       599.1                     515.0                 |
 |NATURAL DEATHS (C)      |       (48.1)                    (  . )                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       699.9                     717.9                 |
 |(STANDARD ERROR)        |       (10.6)                    ( 4.1)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                        SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 723 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 51     UNCENSORED DEATHS 16     CENSORED DEATHS 2    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      492   511   581   594   604   610   611   611   618   661                 |
 |      679   707   709   712   717   720                                         |
 |  CENSORED DEATHS                                                               |
 |      7     373                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = RTD     0 MG/KG                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 3      CENSORED DEATHS 0    TERMINAL 47        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      492   562   628                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                        SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 723 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   723 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0  95.9  89.8  79.6  67.3      |
 |           |                                                                    |
 |           |                                                                    |
 |RTD        |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  96.0  94.0  94.0      |
 |0 MG/KG    |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                0 MG/KG                   RTD                   |
 |                                                          0 MG/KG               |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       67.3%                     94.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----                     -----                |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       633.6                     560.7                 |
 |NATURAL DEATHS (C)      |       (17.9)                    (39.3)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       674.0                     713.3                 |
 |(STANDARD ERROR)        |       (16.8)                    ( 5.8)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        RTD     0 MG/KG  = 2

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                             1                                  2
      |
      |
      |
   98 +                                               1                       1          2                                2
      |
      |
      |
   96 +                                                                       1               1
      |
P     |
E     |
R  94 +                                                                                       1               1
C     |
E     |
N     |
T  92 +                                                                                                       1     1
      |
S     |
U     |
R  90 +
V     |
I     |
V     |
A  88 +                                                                                                             1 1
L     |
      |
      |
   86 +
      |
      |
      |
   84 +                                                                                                               11
      |
      |
      |
   82 +                                                                                                                1  1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 1 obs hidden.
                                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        RTD     0 MG/KG  = 2

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                                             1
      |
      |                                                                               1 1        2
      |                                                                                 1        2 1       2
   95 +
      |                                                                                            1  1    2              2
P     |
E     |                                                                                               1 1
R  90 +                                                                                                 11
C     |
E     |
N     |
T  85 +
      |                                                                                                  11
S     |
U     |                                                                                                   1      1
R  80 +                                                                                                          1 1
V     |
I     |                                                                                                            1   1
V     |
A  75 +                                                                                                                11
L     |
      |
      |                                                                                                                 11
   70 +
      |
      |                                                                                                                  11
      |
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.
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