National Toxicology Program

National Toxicology Program
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TDMS Study 05217-99 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: SOUTHERN RESEARCH INST                                    DATE: 04/25/95   
EXP: 05217                   T-BUTYLHYDROQUINONE               TIME: 04:15:42   
TEST: 99              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C62157   
CONT: N01-ES-85219                                             CAS: 1948-33-0   
PATHOLOGIST: J. E. HEATH                                                        
--------------------------------------------------------------------------------
                                                                                
                       05217/03 -VS- 05217/04 COMPARISON                        
                                                                                

REASONS FOR REMOVAL:                                                            
                                                                                
25019 Moribund Sacrifice                                                        
25020 Natural Death                                                             
25017 Scheduled Sacrifice                                                       
25021 Terminal Sacrifice                                                        
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             

ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE 001    UNTREATD CONTROL                                                 
INCLUDE 002    UNTREATD CONTROL                                                 
INCLUDE 005    RTD UNTRCONTROL                                                  
INCLUDE 006    RTD UNTRCONTROL                                                  
NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST                                    DATE: 04/25/95  
EXP: 05217                   T-BUTYLHYDROQUINONE               TIME: 04:15:42  
TEST: 99              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: C62157  
CONT: N01-ES-85219                                             CAS: 1948-33-0  
PATHOLOGIST: J. E. HEATH                                                       
                                T-BUTYLHYDROQUINONE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 857 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATD CONTROL                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 52     CENSORED DEATHS 10   TERMINAL 8         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      381   489   499   500   528   534   544   556   563   618                 |
 |      618   622   626   642   659   667   668   673   674   674                 |
 |      674   674   687   687   694   704   705   708   710   719                 |
 |      729   730   736   738   750   752   752   757   758   759                 |
 |      761   774   774   785   786   786   786   795   807   808                 |
 |      824   831                                                                 |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    92    92    92    92    92                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = RTD UNTRCONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 47     CENSORED DEATHS 10   TERMINAL 13        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      484   552   569   578   590   593   603   604   612   626                 |
 |      626   626   632   641   661   670   674   688   691   691                 |
 |      698   707   714   719   730   732   745   752   753   754                 |
 |      759   773   778   780   786   786   786   796   802   808                 |
 |      808   808   822   841   841   841   841                                   |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    92    92    92    92    92                  |
 |                                                                                |
 ==================================================================================
                                T-BUTYLHYDROQUINONE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 857 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   857 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATD   |   100.0 100.0 100.0 100.0  98.3  98.3  88.3  85.0  75.0  13.3      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |RTD        |   100.0 100.0 100.0 100.0 100.0  98.3  98.3  86.7  75.0  21.7      |
 |UNTRCONTROL|                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                UNTREATD                  RTD                   |
 |                                CONTROL                   UNTRCONTROL           |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       13.3%                     21.7%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----                     -----                |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       686.1                     710.0                 |
 |NATURAL DEATHS (C)      |       (13.8)                    (13.2)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       620.7                     649.0                 |
 |(STANDARD ERROR)        |       (28.7)                    (29.6)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                T-BUTYLHYDROQUINONE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 898 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATD CONTROL                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 50     CENSORED DEATHS 10   TERMINAL 10        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      297   302   380   418   421   497   540   540   546   578                 |
 |      579   613   627   628   638   640   649   661   690   694                 |
 |      704   712   722   724   733   733   736   758   761   765                 |
 |      765   766   777   778   785   789   795   795   796   799                 |
 |      802   808   830   831   854   855   856   879   880   888                 |
 |  CENSORED DEATHS                                                               |
 |      93    93    93    93    93    93    93    93    93    93                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = RTD UNTRCONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 42     CENSORED DEATHS 10   TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      504   562   575   593   626   638   641   677   688   691                 |
 |      698   710   711   725   730   731   752   771   777   780                 |
 |      786   788   793   808   808   820   822   823   827   828                 |
 |      828   837   837   856   856   862   866   870   870   872                 |
 |      880   892                                                                 |
 |  CENSORED DEATHS                                                               |
 |      92    92    92    92    92    92    92    92    92    92                  |
 |                                                                                |
 ==================================================================================
                                T-BUTYLHYDROQUINONE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 898 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   898 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATD   |   100.0 100.0 100.0  96.7  91.7  91.7  86.7  81.7  70.0  16.7      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |RTD        |   100.0 100.0 100.0 100.0 100.0 100.0  98.3  93.3  88.3  30.0      |
 |UNTRCONTROL|                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                UNTREATD                  RTD                   |
 |                                CONTROL                   UNTRCONTROL           |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       16.7%                     30.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----                     -----                |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       692.3                     762.1                 |
 |NATURAL DEATHS (C)      |       (20.9)                    (15.2)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       636.1                     701.3                 |
 |(STANDARD ERROR)        |       (31.7)                    (32.0)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                        T-BUTYLHYDROQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATD CONTROL = 1
                                                        RTD UNTRCONTROL  = 2

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

             |
             |
         100 +  1                                        1           2
             |                                           1           11    2  2
             |                                                                2
             |                                                        1  11   2 2
          90 +                                                            11    22
             |                                                             111   22
             |                                                               1    212
             |
          80 +                                                                     11
             |                                                                      11 1
       P     |                                                                         11
       E     |                                                                          112
       R  70 +
       C     |                                                                            22
       E     |                                                                             22
       N     |                                                                           11 22
       T  60 +                                                                            11 2 2
             |                                                                             11  22
       S     |                                                                              11  22
       U     |                                                                               1
       R  50 +                                                                               1 1 22
       V     |                                                                                 11 222
       I     |
       V     |                                                                                  11  22
       A  40 +
       L     |                                                                                   11  22
             |                                                                                        22
             |                                                                                    11
          30 +                                                                                         2 2
             |                                                                                     1 1   2 2
             |
             |                                                                                       11    22
          20 +                                                                                        11
             |                                                                                         1 1
             |                                                                                           1
             |                                                                                           1  1
          10 +
             |
             ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
                0             20             40             60             80             100            120            140

                                                                   WEEK

NOTE: 26 obs hidden.
                                                        T-BUTYLHYDROQUINONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATD CONTROL = 1
                                                        RTD UNTRCONTROL  = 2

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

             |
             |
         100 +  1                               1                     2
             |                                  11       1            2      22
             |                                           1   1                2 2
             |                                               11      1          2   22
          90 +                                                       1     1
             |                                                                       2   22
             |                                                             1  1
             |                                                                1   1       22 2
          80 +                                                                    1 1
             |                                                                      11       222
       P     |
       E     |                                                                       111       2 2 2
       R  70 +                                                                         1  1
       C     |                                                                            111      222
       E     |                                                                              11
       N     |                                                                               11      222
       T  60 +                                                                                11
             |                                                                                 11      2 2
       S     |                                                                                  1 1
       U     |                                                                                    11     2
       R  50 +
       V     |                                                                                     1     22
       I     |                                                                                     11     2 2
       V     |                                                                                      11      22
       A  40 +                                                                                       11
       L     |                                                                                               22
             |                                                                                        1
             |                                                                                        11      222
          30 +                                                                                         1 1      22
             |                                                                                           1  1
             |                                                                                              1
             |                                                                                              1  1
          20 +
             |                                                                                                 1 1
             |
             |
          10 +
             |
             ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
                0             20             40             60             80             100            120            140

                                                                   WEEK

NOTE: 20 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.