TDMS Study 05217-99 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST DATE: 04/25/95
EXP: 05217 T-BUTYLHYDROQUINONE TIME: 04:15:42
TEST: 99 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C62157
CONT: N01-ES-85219 CAS: 1948-33-0
PATHOLOGIST: J. E. HEATH
--------------------------------------------------------------------------------
05217/03 -VS- 05217/04 COMPARISON
REASONS FOR REMOVAL:
25019 Moribund Sacrifice
25020 Natural Death
25017 Scheduled Sacrifice
25021 Terminal Sacrifice
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE 001 UNTREATD CONTROL
INCLUDE 002 UNTREATD CONTROL
INCLUDE 005 RTD UNTRCONTROL
INCLUDE 006 RTD UNTRCONTROL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST DATE: 04/25/95
EXP: 05217 T-BUTYLHYDROQUINONE TIME: 04:15:42
TEST: 99 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C62157
CONT: N01-ES-85219 CAS: 1948-33-0
PATHOLOGIST: J. E. HEATH
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 857 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 52 CENSORED DEATHS 10 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 381 489 499 500 528 534 544 556 563 618 |
| 618 622 626 642 659 667 668 673 674 674 |
| 674 674 687 687 694 704 705 708 710 719 |
| 729 730 736 738 750 752 752 757 758 759 |
| 761 774 774 785 786 786 786 795 807 808 |
| 824 831 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
|--------------------------------------------------------------------------------|
| DOSE = RTD UNTRCONTROL |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 47 CENSORED DEATHS 10 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 484 552 569 578 590 593 603 604 612 626 |
| 626 626 632 641 661 670 674 688 691 691 |
| 698 707 714 719 730 732 745 752 753 754 |
| 759 773 778 780 786 786 786 796 802 808 |
| 808 808 822 841 841 841 841 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 857 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 857 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 98.3 98.3 88.3 85.0 75.0 13.3 |
|CONTROL | |
| | |
|RTD | 100.0 100.0 100.0 100.0 100.0 98.3 98.3 86.7 75.0 21.7 |
|UNTRCONTROL| |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD RTD |
| CONTROL UNTRCONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 13.3% 21.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 686.1 710.0 |
|NATURAL DEATHS (C) | (13.8) (13.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 620.7 649.0 |
|(STANDARD ERROR) | (28.7) (29.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 898 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 50 CENSORED DEATHS 10 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 297 302 380 418 421 497 540 540 546 578 |
| 579 613 627 628 638 640 649 661 690 694 |
| 704 712 722 724 733 733 736 758 761 765 |
| 765 766 777 778 785 789 795 795 796 799 |
| 802 808 830 831 854 855 856 879 880 888 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 93 |
| |
|--------------------------------------------------------------------------------|
| DOSE = RTD UNTRCONTROL |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 42 CENSORED DEATHS 10 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 504 562 575 593 626 638 641 677 688 691 |
| 698 710 711 725 730 731 752 771 777 780 |
| 786 788 793 808 808 820 822 823 827 828 |
| 828 837 837 856 856 862 866 870 870 872 |
| 880 892 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 898 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 898 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 96.7 91.7 91.7 86.7 81.7 70.0 16.7 |
|CONTROL | |
| | |
|RTD | 100.0 100.0 100.0 100.0 100.0 100.0 98.3 93.3 88.3 30.0 |
|UNTRCONTROL| |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD RTD |
| CONTROL UNTRCONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 16.7% 30.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 692.3 762.1 |
|NATURAL DEATHS (C) | (20.9) (15.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 636.1 701.3 |
|(STANDARD ERROR) | (31.7) (32.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYLHYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
RTD UNTRCONTROL = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 1 11 2 2
| 2
| 1 11 2 2
90 + 11 22
| 111 22
| 1 212
|
80 + 11
| 11 1
P | 11
E | 112
R 70 +
C | 22
E | 22
N | 11 22
T 60 + 11 2 2
| 11 22
S | 11 22
U | 1
R 50 + 1 1 22
V | 11 222
I |
V | 11 22
A 40 +
L | 11 22
| 22
| 11
30 + 2 2
| 1 1 2 2
|
| 11 22
20 + 11
| 1 1
| 1
| 1 1
10 +
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 26 obs hidden.
T-BUTYLHYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
RTD UNTRCONTROL = 2
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 11 1 2 22
| 1 1 2 2
| 11 1 2 22
90 + 1 1
| 2 22
| 1 1
| 1 1 22 2
80 + 1 1
| 11 222
P |
E | 111 2 2 2
R 70 + 1 1
C | 111 222
E | 11
N | 11 222
T 60 + 11
| 11 2 2
S | 1 1
U | 11 2
R 50 +
V | 1 22
I | 11 2 2
V | 11 22
A 40 + 11
L | 22
| 1
| 11 222
30 + 1 1 22
| 1 1
| 1
| 1 1
20 +
| 1 1
|
|
10 +
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 20 obs hidden.