National Toxicology Program

National Toxicology Program
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TDMS Study 97013-07 Pathology Tables

NTP  EXP/TEST: 97013-07                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/11/04
ROUTE: GAVAGE                                                                                                     TIME: 08:07:35

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013G

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  75-27-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-07                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/11/04
ROUTE: GAVAGE                                               EISRPT03                                              TIME: 08:07:35
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 SPECIES-STRAIN: P53(C57BL/6)-MICE          SEX: FEMALE      WEEK ON DOSE: 27     FIRST DOSE: 09/16/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     19.4    1.2        15     31.3    5.2                     15     12.0    4.4

 25 MG/KG           15     18.8    1.4        14     31.0    4.4        99.0         14     12.0    4.0

 50 MG/KG           15     19.2    1.3        14     29.3    4.0        93.6         14     10.1    3.5

 100     MG/KG      15     19.4    1.0        14     29.6    3.5        94.5         14     10.3    2.9




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 SPECIES-STRAIN: P53(C57BL/6)-MICE          SEX: MALE        WEEK ON DOSE: 27     FIRST DOSE: 09/16/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     23.5    1.9        15     45.6    5.1                     15     22.2    4.7

 25 MG/KG           15     23.7    1.6        15     44.7    5.3        98.0         15     21.0    4.9

 50 MG/KG           15     21.6    2.4        15     35.8    5.4        78.5         15     14.2    5.8

 100     MG/KG      15     22.8    2.4        15     32.7    5.3        71.7         15      9.9    4.4

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