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TDMS Study 97013-14 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                   WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                             DATE: 01/27/05  
EXPERIMENT: 97013 TEST: 14                                                                                        TIME: 09:11:30    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED WATER                                            NTP:  C97013C     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (DICHLOROACETIC ACID)              DATE: 01/27/05    
EXPERIMENT: 97013 TEST: 14                                                                                        TIME:  9:16:26    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED WATER                                            NTP:  97013C      
CONT: N01-ES-65406                                                                                                CAS: 79-43-6      
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                        SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    
==================================================================================================================================  
           0 MG/L                     500 MG/L                           1000MG/L                           2000MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     3.3    24.1       3.2     24.0    0.97       66      2.8     23.7    0.85      118      2.4     22.8    0.73      207       
  3     3.0    25.1       3.0     24.8    1.00       61      2.5     23.8    0.83      106      2.2     23.6    0.73      189       
  4     3.0    26.4       3.0     26.2    1.00       57      2.7     25.4    0.90      107      2.1     24.3    0.70      176       
  5     3.1    27.8       3.0     27.6    0.97       55      2.6     26.1    0.84      100      2.1     25.1    0.68      166       
  6     3.1    28.9       3.0     28.5    0.97       52      2.6     26.6    0.84       97      2.1     25.5    0.68      168       
  7     3.1    30.7       2.9     29.8    0.94       49      2.7     27.9    0.87       95      1.9     25.9    0.61      148       
  8     3.1    31.9       2.9     30.7    0.94       48      2.6     28.6    0.84       93      2.2     26.5    0.71      166       
  9     3.1    33.3       3.1     31.7    1.00       48      2.5     29.2    0.81       87      2.1     27.1    0.68      158       
 10     3.3    34.7       3.1     33.2    0.94       46      2.6     29.8    0.79       86      2.1     27.4    0.64      152       
 11     3.2    36.2       2.9     34.0    0.91       42      2.5     30.5    0.78       82      2.1     27.9    0.66      148       
 12     3.4    37.4       3.1     35.2    0.91       44      2.5     31.1    0.74       81      2.0     28.4    0.59      141       
 13     3.3    38.6       3.1     36.2    0.94       42      2.4     31.1    0.73       78      1.9     28.6    0.58      136       
 14     3.6    39.5       3.3     37.1    0.92       45      2.5     31.5    0.69       79      2.1     29.2    0.58      145       
 15     3.5    40.9       3.0     38.4    0.86       40      2.6     32.5    0.74       80      2.0     29.4    0.57      134       
 16     3.5    41.4       3.1     38.6    0.89       40      2.5     32.4    0.71       77      2.3     29.5    0.66      156       
 17     3.8    42.1       3.1     39.8    0.82       39      2.5     33.1    0.66       76      1.9     29.4    0.50      132       
 18     3.6    43.4       3.0     40.6    0.83       37      2.5     33.8    0.69       73      2.1     30.5    0.58      140       
 19     3.6    44.6       3.2     41.7    0.89       38      2.5     34.6    0.69       73      2.0     31.1    0.56      132       
 20     3.6    44.9       3.1     42.2    0.86       37      2.5     35.0    0.69       71      2.0     31.5    0.56      130       
 21     3.6    45.5       3.0     43.2    0.83       35      2.5     35.6    0.69       70      2.1     31.8    0.58      129       
 22     3.5    45.8       3.0     43.5    0.86       35      2.4     35.8    0.69       67      2.1     32.2    0.60      129       
 23     3.7    46.2       3.1     44.0    0.84       35      2.4     36.1    0.65       66      2.0     32.4    0.54      123       
 24     3.6    46.7       3.2     44.4    0.89       36      2.5     36.8    0.69       67      2.1     33.1    0.58      126       
 25     3.7    46.9       3.0     44.6    0.81       34      2.3     36.6    0.62       64      2.0     32.3    0.54      127       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.2    31.3       3.0     30.2    0.96       51      2.6     27.8    0.82       94      2.1     26.1    0.66      163       
SD(D)   0.1               0.1             0.03        8      0.1             0.05       12      0.1             0.05       20       
CV(E)   4.0               2.6             3.5      14.8      4.0             6.3      12.9      5.8             7.8      12.5       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    3.6    44.0       3.1     41.5    0.86       37      2.5     34.5    0.69       72      2.1     31.0    0.57      134       
SD(D)   0.1               0.1             0.03        3      0.1             0.03        5      0.1             0.04        9       
CV(E)   2.4               2.9             3.8       8.1      2.7             4.6       7.4      4.5             6.7       6.9       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                        SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    
==================================================================================================================================  
           0 MG/L                     500 MG/L                           1000MG/L                           2000MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     3.9    19.5       3.8     19.6     0.97      96      3.6     19.5     0.92     185      2.6     18.5     0.67     277       
  3     4.0    19.9       3.9     20.1     0.98      96      3.3     19.7     0.83     166      2.3     18.7     0.58     246       
  4     3.9    20.9       4.0     20.6     1.03      97      3.4     20.3     0.87     169      2.4     19.6     0.62     247       
  5     4.1    21.5       4.4     21.3     1.07     103      3.3     20.9     0.80     160      2.5     20.3     0.61     245       
  6     4.2    21.7       4.0     21.4     0.95      95      3.4     20.9     0.81     164      2.5     20.7     0.60     244       
  7     4.0    21.9       3.7     21.7     0.93      85      3.4     21.5     0.85     156      2.4     21.3     0.60     230       
  8     4.1    23.0       4.1     22.6     1.00      90      3.3     22.3     0.80     146      2.5     22.0     0.61     224       
  9     3.9    23.3       3.9     22.9     1.00      86      3.0     21.3     0.77     141      2.4     21.8     0.62     216       
 10     4.2    23.2       3.6     22.3     0.86      81      3.6     22.2     0.86     162      2.7     22.4     0.64     237       
 11     3.9    23.7       3.9     23.1     1.00      84      3.2     22.5     0.82     141      2.6     22.2     0.67     230       
 12     4.1    24.5       4.0     23.9     0.98      84      3.2     22.9     0.78     140      2.5     22.8     0.61     218       
 13     4.1    24.3       3.9     23.9     0.95      82      3.1     22.8     0.76     137      2.3     22.7     0.56     204       
 14     4.3    24.7       4.5     24.5     1.05      91      3.4     23.3     0.79     146      2.3     22.8     0.53     202       
 15     4.1    25.3       3.9     24.7     0.95      79      3.3     23.6     0.80     142      2.5     23.4     0.61     216       
 16     4.6    25.5       4.3     24.6     0.93      87      3.2     23.7     0.70     134      2.7     23.4     0.59     233       
 17     3.8    24.6       3.7     24.8     0.97      74      3.0     23.2     0.79     128      2.7     22.6     0.71     242       
 18     4.6    26.8       3.7     25.3     0.80      74      3.4     24.1     0.74     141      2.4     23.7     0.52     204       
 19     4.2    27.0       3.8     26.3     0.90      73      3.2     24.3     0.76     131      2.4     23.8     0.57     198       
 20     4.5    27.4       3.7     26.4     0.82      69      3.2     24.3     0.71     133      2.6     24.3     0.58     213       
 21     4.7    28.1       3.8     27.5     0.81      68      3.2     24.6     0.68     130      2.4     24.5     0.51     196       
 22     4.5    28.1       3.8     27.3     0.84      70      3.3     24.6     0.73     133      2.5     24.4     0.56     201       
 23     4.3    29.1       3.8     27.6     0.88      68      3.0     24.5     0.70     121      2.5     24.4     0.58     203       
 24     4.0    29.2       4.1     27.9     1.03      73      3.2     24.6     0.80     129      2.4     24.7     0.60     195       
 25     4.2    30.0       3.9     28.5     0.93      68      3.0     24.9     0.71     122      2.4     24.7     0.57     198       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.0    22.3       3.9     21.9     0.98      90      3.3     21.4     0.82     155      2.5     21.1     0.61     235       
SD(D)   0.1               0.2              0.05       7      0.2              0.05      15      0.1              0.03      19       
CV(E)   3.1               5.0              5.5      7.9      5.6              5.7      9.6      4.3              5.2      8.1       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.3    27.2       3.9     26.3     0.91      75      3.2     24.1     0.74     133      2.5     23.9     0.58     208       
SD(D)   0.3               0.2              0.08       7      0.1              0.04       7      0.1              0.05      15       
CV(E)   6.4               6.2              8.9     10.0      4.6              6.0      5.6      5.4              8.9      7.2       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
          DIAGNOSTIC TRAILER REPORT                                                                                                 
          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                        
          SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                                  
=========================================================================================================                           
           0 MG/L                  500 MG/L                 1000MG/L                 2000MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               23.1  15                 23.1  15                 22.7  15                 22.9  15                               
  1               23.1  15                 23.1  15                 22.7  15                 22.9  15                               
  2   3.3  2440   24.1  15     3.2  2440   24.0  15     2.8  2396   23.7  15     2.4  2440   22.8  15                               
  3   3.0  2580   25.1  15     3.0  2430   24.8  15     2.5  2286   23.8  15     2.2  2408   23.6  15                               
  4   3.0  2495   26.4  15     3.0  2439   26.2  15     2.7  2331   25.4  15     2.1  2485   24.3  15                               
  5   3.1  2500   27.8  15     3.0  2373   27.6  15     2.6  2540   26.1  15     2.1  2354   25.1  15                               
  6   3.1  2520   28.9  15     3.0  2520   28.5  15     2.6  2233   26.6  15     2.1  2425   25.5  15                               
  7   3.1  2525   30.7  15     2.9  2515   29.8  15     2.7  2510   27.9  15     1.9  2367   25.9  15                               
  8   3.1  2505   31.9  15     2.9  2505   30.7  15     2.6  2500   28.6  15     2.2  2505   26.5  15                               
  9   3.1  2323   33.3  15     3.1  2353   31.7  15     2.5  2525   29.2  15     2.1  2520   27.1  15                               
 10   3.3  2299   34.7  15     3.1  2438   33.2  15     2.6  2172   29.8  15     2.1  2510   27.4  15                               
 11   3.2  2535   36.2  15     2.9  2270   34.0  15     2.5  2126   30.5  15     2.1  2535   27.9  15                               
 12   3.4  2338   37.4  15     3.1  2316   35.2  15     2.5  2224   31.1  15     2.0  2176   28.4  15                               
 13   3.3  2565   38.6  15     3.1  2394   36.2  15     2.4  2394   31.1  15     1.9  2223   28.6  15                               
 14   3.6  2490   39.5  15     3.3  2490   37.1  15     2.5  1974   31.5  15     2.1  2490   29.2  15                               
 15   3.5  2520   40.9  15     3.0  2347   38.4  15     2.6  2391   32.5  15     2.0  2515   29.4  15                               
 16   3.5  2555   41.4  15     3.1  2556   38.6  15     2.5  2550   32.4  15     2.3  1866   29.5  15                               
 17   3.8  2082   42.1  15     3.1  2294   39.8  15     2.5  1937   33.1  15     1.9  1949   29.4  15                               
 18   3.6  2496   43.4  15     3.0  2505   40.6  15     2.5  2515   33.8  15     2.1  2338   30.5  15                               
 19   3.6  2473   44.6  15     3.2  2341   41.7  15     2.5  2520   34.6  15     2.0  2341   31.1  15                               
 20   3.6  2421   44.9  15     3.1  2556   42.2  15     2.5  2550   35.0  15     2.0  2385   31.5  15                               
 21   3.6  2320   45.5  15     3.0  2490   43.2  15     2.5  2371   35.6  15     2.1  2490   31.8  15                               
 22   3.5  2371   45.8  15     3.0  2545   43.5  15     2.4  2555   35.8  15     2.1  2550   32.2  15                               
 23   3.7  2544   46.2  15     3.1  2422   44.0  15     2.4  2540   36.1  15     2.0  2540   32.4  15                               
 24   3.6  2510   46.7  15     3.2  2496   44.4  15     2.5  2487   36.8  15     2.1  2501   33.1  15                               
 25   3.7  2542   46.9  15     3.0  2555   44.6  15     2.3  2545   36.6  15     2.0  2206   32.3  15                               
 26   3.7  2535                3.1  2534                2.4  2540                2.1  2539                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           30.6                     29.6                     27.4                     25.8                                   
14 TO 52          44.0                     41.5                     34.5                     31.0                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
          DIAGNOSTIC TRAILER REPORT                                                                                                 
          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                      
          SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                                  
=========================================================================================================                           
           0 MG/L                  500 MG/L                 1000MG/L                 2000MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               18.7  15                 18.6  15                 18.8  15                 18.4  15                               
  1               18.7  15                 18.6  15                 18.8  15                 18.4  15                               
  2   3.9  2440   19.5  15     3.8  2327   19.6  15     3.6  2282   19.5  15     2.6  2435   18.5  15                               
  3   4.0  2580   19.9  15     3.9  2580   20.1  15     3.3  2580   19.7  15     2.3  2133   18.7  15                               
  4   3.9  2485   20.9  15     4.0  2320   20.6  15     3.4  2495   20.3  15     2.4  2475   19.6  15                               
  5   4.1  2354   21.5  15     4.4  2067   21.3  15     3.3  2389   20.9  15     2.5  2215   20.3  15                               
  6   4.2  2520   21.7  15     4.0  2016   21.4  15     3.4  2352   20.9  15     2.5  2253   20.7  15                               
  7   4.0  2327   21.9  15     3.7  1834   21.7  15     3.4  2342   21.5  15     2.4  2188   21.3  15                               
  8   4.1  2500   23.0  15     4.1  2004   22.6  15     3.3  2505   22.3  15     2.5  2329   22.0  15                               
  9   3.9  2520   23.3  15     3.9  2068   22.9  15     3.0  2021   21.3  15     2.4  2010   21.8  15                               
 10   4.2  2510   23.2  15     3.6  1674   22.3  15     3.6  2515   22.2  15     2.7  2505   22.4  15                               
 11   3.9  2535   23.7  15     3.9  2124   23.1  15     3.2  2485   22.5  15     2.6  2146   22.2  15                               
 12   4.1  2264   24.5  15     4.0  2057   23.9  15     3.2  2510   22.9  15     2.5  2166   22.8  15                               
 13   4.1  2565   24.3  15     3.9  2052   23.9  15     3.1  2565   22.8  15     2.3  2394   22.7  15                               
 14   4.3  2490   24.7  15     4.5  1992   24.5  15     3.4  2490   23.3  15     2.3  2135   22.8  15                               
 15   4.1  2348   25.3  15     3.9  2343   24.7  15     3.3  2515   23.6  15     2.5  2394   23.4  15                               
 16   4.6  2550   25.5  15     4.3  2217   24.6  15     3.2  2380   23.7  15     2.7  2197   23.4  15                               
 17   3.8  1744   24.6  15     3.7  1912   24.8  15     3.0  1719   23.2  15     2.7  1577   22.6  15                               
 18   4.6  2171   26.8  15     3.7  2056   25.3  15     3.4  2500   24.1  15     2.4  2510   23.7  15                               
 19   4.2  2314   27.0  15     3.8  1964   26.3  15     3.2  2343   24.3  15     2.4  2406   23.8  15                               
 20   4.5  2343   27.4  15     3.7  1996   26.4  15     3.2  2565   24.3  15     2.6  2558   24.3  15                               
 21   4.7  2325   28.1  15     3.8  1985   27.5  15     3.2  2315   24.6  15     2.4  2399   24.5  15                               
 22   4.5  2185   28.1  15     3.8  1746   27.3  15     3.3  2371   24.6  15     2.5  2555   24.4  15                               
 23   4.3  2244   29.1  15     3.8  1746   27.6  15     3.0  2380   24.5  15     2.5  2535   24.4  15                               
 24   4.0  2495   29.2  15     4.1  1987   27.9  15     3.2  2501   24.6  15     2.4  2496   24.7  15                               
 25   4.2  2376   30.0  15     3.9  1754   28.5  15     3.0  2237   24.9  14     2.4  2375   24.7  14                               
 26   4.1  2535                3.8  2192                2.8  2357                2.4  2372                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           22.0                     21.7                     21.2                     20.9                                   
14 TO 52          27.2                     26.3                     24.1                     23.9                                   
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    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.