National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11143

TDMS Study 97013-90 Pathology Tables

NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:37:03

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:37:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              1                                                               
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9           10            9                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                    10 [1.1]     10 [1.0]     10 [1.2]      9 [1.4]                               
      Hepatocyte, Fatty Change                         1 [1.0]                                                                      
      Hepatocyte, Necrosis                                                       1 [1.0]                                            
      Hepatocyte, Vacuolization Cytoplasmic           10 [1.9]     10 [2.7]     10 [3.7]     10 [3.6]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                             2 [1.5]                                                         
      Subcapsular, Hyperplasia                        10 [1.3]     10 [1.4]      9 [1.0]     10 [1.1]                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                                                        1 [1.0]      1 [1.0]                               
      Pars Distalis, Hyperplasia                                    1 [1.0]      1 [2.0]                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ectopic Thymus                                                                          1 [3.0]                               
      Infiltration Cellular, Lymphocyte                                                       2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:37:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                                          1 [2.0]      1 [3.0]      7 [2.0]                               
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     2 [1.0]      1 [1.0]      1 [1.0]                                            
      Endometrium, Hyperplasia, Cystic                 7 [1.7]      9 [1.4]      9 [1.9]      9 [2.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                         2 [2.0]                                                         
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 [2.0]      2 [2.0]                   2 [2.0]                               
      Hyperplasia, Lymphoid                                         1 [3.0]                                                         
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 1 [3.0]                               
      Cyst                                             9 [1.7]      8 [1.4]      7 [1.4]      8 [1.8]                               
      Ectopic Parathyroid Gland                                     1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                                            (1)                       (1)                                    
      Hyperkeratosis                                                1 [2.0]                                                         
      Hyperplasia                                                   1 [3.0]                                                         
      Inflammation, Chronic Active                                  1 [2.0]                                                         
      Ulcer                                                         1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:37:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 1 [4.0]                               
      Metaplasia, Osseous                                                        1 [1.0]                                            
      Mineralization                                                2 [1.0]      3 [1.0]                                            
      Nephropathy                                      4 [1.0]      4 [1.0]      7 [1.0]      5 [1.0]                               
      Renal Tubule, Dilatation                                                   1 [1.0]      1 [2.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:37:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            9           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 [2.0]                                                                      
      Inflammation, Chronic Active                     9 [1.0]      8 [1.0]      7 [1.0]      9 [1.0]                               
      Hepatocyte, Fatty Change                         6 [1.0]      5 [1.8]                                                         
      Hepatocyte, Necrosis                             1 [2.0]                                                                      
      Hepatocyte, Vacuolization Cytoplasmic            9 [3.6]     10 [3.0]     10 [3.7]     10 [3.8]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     1 [2.0]                   1 [2.0]                                            
      Ulcer                                            1 [3.0]                   1 [4.0]                                            
      Epithelium, Hyperkeratosis                       1 [2.0]                   1 [3.0]                                            
      Epithelium, Hyperplasia                          1 [4.0]                   1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hypertrophy                                      3 [1.0]      3 [1.7]      1 [1.0]                                            
      Subcapsular, Hyperplasia                         3 [1.0]      5 [1.0]      3 [1.0]      3 [1.0]                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                              4 [1.0]      2 [1.0]      2 [1.0]                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                1 [2.0]      1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:37:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Degeneration                                                                            1 [4.0]                               
      Inflammation, Chronic Active                     3 [1.0]      2 [1.0]      1 [1.0]      3 [1.0]                               
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                                                          1 [1.0]                               
      Germinal Epithelium, Degeneration                5 [1.0]      4 [1.0]      2 [1.0]      4 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                            1 [2.0]                                                                      
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 [4.0]      1 [2.0]                                                         
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 [3.0]                                                                      
      Cyst                                             6 [2.0]      3 [1.3]      2 [2.0]      2 [1.5]                               
      Ectopic Parathyroid Gland                                                  2 [1.0]      3 [1.0]                               
      Hyperplasia, Lymphoid                            1 [2.0]      1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:37:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Thrombosis                                                    1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Hydronephrosis                                                                          1 [2.0]                               
      Metaplasia, Osseous                                                                     1 [1.0]                               
      Mineralization                                   1 [1.0]                                                                      
      Nephropathy                                      9 [1.0]      6 [1.0]      8 [1.0]      8 [1.0]                               
      Renal Tubule, Dilatation                         1 [1.0]      2 [1.0]                   1 [2.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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